TRAJ52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)6.31586201
2negative regulation by host of viral transcription (GO:0043922)5.97178395
3pyrimidine nucleoside catabolic process (GO:0046135)5.96805292
4positive regulation of natural killer cell mediated immunity (GO:0002717)5.95037267
5eosinophil chemotaxis (GO:0048245)5.84341192
6positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.79942816
7negative T cell selection (GO:0043383)5.57111181
8actin nucleation (GO:0045010)5.54862507
9positive regulation of interleukin-8 secretion (GO:2000484)5.53661180
10negative regulation of viral genome replication (GO:0045071)5.39107998
11positive regulation of B cell differentiation (GO:0045579)5.33620086
12eosinophil migration (GO:0072677)5.28428624
13positive regulation of gamma-delta T cell activation (GO:0046645)5.08879292
14positive regulation of defense response to virus by host (GO:0002230)5.04694874
15regulation of natural killer cell mediated immunity (GO:0002715)4.98606735
16regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.98606735
17T cell migration (GO:0072678)4.75638482
18macrophage chemotaxis (GO:0048246)4.74382941
19cellular response to interleukin-15 (GO:0071350)4.63351890
20positive regulation of calcium-mediated signaling (GO:0050850)4.57215242
21positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.44412324
22cytolysis (GO:0019835)4.43707654
23negative thymic T cell selection (GO:0045060)4.38145285
24lymphocyte chemotaxis (GO:0048247)4.33482322
25positive T cell selection (GO:0043368)4.31904737
26negative regulation of T cell apoptotic process (GO:0070233)4.30080685
27regulation of lymphocyte chemotaxis (GO:1901623)4.27039845
28regulation of B cell differentiation (GO:0045577)4.26909291
29negative regulation of viral transcription (GO:0032897)4.18539452
30regulation of B cell receptor signaling pathway (GO:0050855)4.14138219
31regulation of gamma-delta T cell differentiation (GO:0045586)4.08127223
32regulation of interleukin-8 secretion (GO:2000482)4.07999656
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.06362016
34DNA demethylation (GO:0080111)4.03972122
35positive regulation of interleukin-1 beta secretion (GO:0050718)4.02276699
36thymic T cell selection (GO:0045061)3.99217217
37positive regulation of alpha-beta T cell proliferation (GO:0046641)3.95656765
38positive regulation of cell killing (GO:0031343)3.94927323
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91938494
40positive thymic T cell selection (GO:0045059)3.91336628
41regulation of activation of Janus kinase activity (GO:0010533)3.84085669
42regulation of leukocyte mediated cytotoxicity (GO:0001910)3.81274739
43positive regulation of interleukin-1 secretion (GO:0050716)3.80763120
44negative regulation of viral process (GO:0048525)3.80597376
45regulation of viral genome replication (GO:0045069)3.78164474
46regulation of interleukin-1 beta secretion (GO:0050706)3.72119472
47regulation of regulatory T cell differentiation (GO:0045589)3.66872094
48pyrimidine ribonucleoside metabolic process (GO:0046131)3.66741317
49response to interleukin-15 (GO:0070672)3.63997076
50T cell costimulation (GO:0031295)3.63061470
51lymphocyte costimulation (GO:0031294)3.58550255
52pyrimidine-containing compound catabolic process (GO:0072529)3.56009875
53regulation of interleukin-12 biosynthetic process (GO:0045075)3.55614284
54positive regulation of lymphocyte migration (GO:2000403)3.54945700
55regulation of gamma-delta T cell activation (GO:0046643)3.52463416
56regulation of interleukin-2 biosynthetic process (GO:0045076)3.49295153
57T cell selection (GO:0045058)3.47346399
58response to pheromone (GO:0019236)3.45556212
59positive regulation of tolerance induction (GO:0002645)3.42936797
60cellular defense response (GO:0006968)3.41183508
61regulation of cell killing (GO:0031341)3.37057374
62production of molecular mediator involved in inflammatory response (GO:0002532)3.34225292
63regulation of T cell tolerance induction (GO:0002664)3.32486348
64regulation of interleukin-1 secretion (GO:0050704)3.31948009
65regulation of chronic inflammatory response (GO:0002676)3.30394014
66regulation of alpha-beta T cell proliferation (GO:0046640)3.30083715
67positive regulation of interleukin-1 beta production (GO:0032731)3.25819957
68regulation of calcium-mediated signaling (GO:0050848)3.19220293
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17552781
70lymphocyte migration (GO:0072676)3.14463948
71positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13811299
72T cell receptor signaling pathway (GO:0050852)3.09981500
73negative regulation of lymphocyte apoptotic process (GO:0070229)3.07279703
74modulation by host of symbiont transcription (GO:0052472)3.05274546
75modulation by host of viral transcription (GO:0043921)3.05274546
76T cell mediated immunity (GO:0002456)3.03105966
77DNA dealkylation (GO:0035510)3.02696653
78immunoglobulin mediated immune response (GO:0016064)3.00461490
79modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.00424709
80membrane raft organization (GO:0031579)2.98032301
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96247541
82monocyte chemotaxis (GO:0002548)2.94022078
83positive regulation of interleukin-1 production (GO:0032732)2.87438007
84regulation of defense response to virus by host (GO:0050691)2.83238854
85regulation of memory T cell differentiation (GO:0043380)2.82678828
86regulation of isotype switching to IgG isotypes (GO:0048302)2.81816153
87regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.80054022
88granulocyte activation (GO:0036230)2.77126149
89natural killer cell activation (GO:0030101)2.73800907
90sarcoplasmic reticulum calcium ion transport (GO:0070296)2.73548847
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73279231
92antigen processing and presentation via MHC class Ib (GO:0002475)2.70525525
93heterotypic cell-cell adhesion (GO:0034113)2.70279599
94regulation of lymphocyte migration (GO:2000401)2.69868931
95cytidine catabolic process (GO:0006216)14.6265832
96cytidine deamination (GO:0009972)14.6265832
97cytidine metabolic process (GO:0046087)14.6265832
98pyrimidine ribonucleoside catabolic process (GO:0046133)13.1281608
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509112.4217090
100DNA deamination (GO:0045006)11.0537730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.10699929
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.98405390
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.92158980
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.46373607
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.45177005
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40617580
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23182187
8MYB_26560356_Chip-Seq_TH2_Human3.15101583
9STAT4_19710469_ChIP-ChIP_TH1__Mouse2.97224487
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.57997464
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.50003910
12RUNX_20019798_ChIP-Seq_JUKART_Human2.41871887
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38932292
14GATA3_27048872_Chip-Seq_THYMUS_Human2.28460457
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26280831
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20650430
17HTT_18923047_ChIP-ChIP_STHdh_Human2.15921380
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11040554
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09947741
20BP1_19119308_ChIP-ChIP_Hs578T_Human10.4992036
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.97387358
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85088672
23MYB_26560356_Chip-Seq_TH1_Human1.83924915
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78848699
25EZH2_22144423_ChIP-Seq_EOC_Human1.77661210
26GATA3_26560356_Chip-Seq_TH2_Human1.71913146
27UTX_26944678_Chip-Seq_JUKART_Human1.71401244
28MAF_26560356_Chip-Seq_TH2_Human1.70859260
29RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.65119248
30TAF15_26573619_Chip-Seq_HEK293_Human1.63787420
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63654554
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63181473
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61572948
34MAF_26560356_Chip-Seq_TH1_Human1.60141743
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49457227
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47888741
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45716403
38PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.45602088
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.41554513
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33464882
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33164097
42VDR_22108803_ChIP-Seq_LS180_Human1.32582247
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26561648
44BCL6_27268052_Chip-Seq_Bcells_Human1.20148461
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19499208
46TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17859932
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17295887
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15477691
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14903577
50GATA1_22025678_ChIP-Seq_K562_Human1.13229446
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12933193
52VDR_23849224_ChIP-Seq_CD4+_Human1.12786745
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.12387995
54IGF1R_20145208_ChIP-Seq_DFB_Human1.07591312
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.05901023
56MYC_19829295_ChIP-Seq_ESCs_Human1.05423344
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05373907
58SPI1_23547873_ChIP-Seq_NB4_Human1.04687926
59IRF1_19129219_ChIP-ChIP_H3396_Human1.01331656
60EGR1_19032775_ChIP-ChIP_M12_Human0.99885836
61GBX2_23144817_ChIP-Seq_PC3_Human0.98545031
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97859754
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97618334
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94463864
65GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94302415
66HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93844054
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93406663
68CTCF_20526341_ChIP-Seq_ESCs_Human0.92267991
69GATA6_21074721_ChIP-Seq_CACO-2_Human0.91459163
70FOXP3_21729870_ChIP-Seq_TREG_Human0.90151410
71FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89296129
72FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87116500
73FOXA1_25329375_ChIP-Seq_VCAP_Human0.87116500
74GATA3_26560356_Chip-Seq_TH1_Human0.87095939
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86658539
76TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84503703
77BCOR_27268052_Chip-Seq_Bcells_Human0.84405933
78SA1_27219007_Chip-Seq_Bcells_Human0.82992101
79RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82510362
80TAF2_19829295_ChIP-Seq_ESCs_Human0.80548548
81SCL_19346495_ChIP-Seq_HPC-7_Human0.78399856
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78249331
83AR_20517297_ChIP-Seq_VCAP_Human0.77612068
84OCT4_20526341_ChIP-Seq_ESCs_Human0.75429091
85FOXH1_21741376_ChIP-Seq_ESCs_Human0.74861534
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73991192
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73959377
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73317146
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.73150171
90SOX2_19829295_ChIP-Seq_ESCs_Human0.72917519
91NANOG_19829295_ChIP-Seq_ESCs_Human0.72917519
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72732914
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.72096482
94RBPJ_21746931_ChIP-Seq_IB4_Human0.71424366
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.71342802
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.70951228
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70950847
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.69730170
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.68822935
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67899379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.09952519
2MP0009785_altered_susceptibility_to4.71542482
3MP0003763_abnormal_thymus_physiology4.12273521
4MP0006082_CNS_inflammation4.05697302
5MP0009333_abnormal_splenocyte_physiolog3.85271571
6MP0001835_abnormal_antigen_presentation3.19150396
7MP0005000_abnormal_immune_tolerance3.11160181
8MP0003448_altered_tumor_morphology2.71003753
9MP0002420_abnormal_adaptive_immunity2.70986320
10MP0002166_altered_tumor_susceptibility2.68761144
11MP0005025_abnormal_response_to2.62526448
12MP0002148_abnormal_hypersensitivity_rea2.59355414
13MP0001819_abnormal_immune_cell2.59020040
14MP0001800_abnormal_humoral_immune2.57247714
15MP0002723_abnormal_immune_serum2.51773709
16MP0001790_abnormal_immune_system2.37616633
17MP0005387_immune_system_phenotype2.37616633
18MP0003045_fibrosis2.31215368
19MP0003436_decreased_susceptibility_to2.21692422
20MP0002398_abnormal_bone_marrow2.15215457
21MP0000703_abnormal_thymus_morphology2.15035440
22MP0002006_tumorigenesis2.10216966
23MP0000716_abnormal_immune_system2.06470679
24MP0010155_abnormal_intestine_physiology1.96764400
25MP0003866_abnormal_defecation1.95987404
26MP0002452_abnormal_antigen_presenting1.94178121
27MP0004145_abnormal_muscle_electrophysio1.89095261
28MP0002419_abnormal_innate_immunity1.77811174
29MP0003786_premature_aging1.74104719
30MP0002722_abnormal_immune_system1.72793223
31MP0000689_abnormal_spleen_morphology1.67478867
32MP0001845_abnormal_inflammatory_respons1.65926206
33MP0002405_respiratory_system_inflammati1.65877004
34MP0009763_increased_sensitivity_to1.63285466
35MP0002429_abnormal_blood_cell1.59894546
36MP0000685_abnormal_immune_system1.59762600
37MP0002009_preneoplasia1.57112775
38MP0002933_joint_inflammation1.55519058
39MP0001873_stomach_inflammation1.55355727
40MP0002277_abnormal_respiratory_mucosa1.50542713
41MP0009765_abnormal_xenobiotic_induced1.49115140
42MP0000569_abnormal_digit_pigmentation1.42819322
43MP0005410_abnormal_fertilization1.41133452
44MP0008469_abnormal_protein_level1.37567735
45MP0001501_abnormal_sleep_pattern1.32375720
46MP0003252_abnormal_bile_duct1.31697042
47MP0002138_abnormal_hepatobiliary_system1.30685724
48MP0004947_skin_inflammation1.28734077
49MP0000858_altered_metastatic_potential1.28253799
50MP0002876_abnormal_thyroid_physiology1.24940979
51MP0002132_abnormal_respiratory_system1.22913603
52MP0003646_muscle_fatigue1.15920041
53MP0003075_altered_response_to1.15073259
54MP0000639_abnormal_adrenal_gland1.12459739
55MP0003279_aneurysm1.10191923
56MP0008877_abnormal_DNA_methylation1.02135636
57MP0001853_heart_inflammation1.00190998
58MP0001958_emphysema1.00020978
59MP0002168_other_aberrant_phenotype0.95974680
60MP0009764_decreased_sensitivity_to0.93275816
61MP0001533_abnormal_skeleton_physiology0.92584778
62MP0003567_abnormal_fetal_cardiomyocyte0.90839604
63MP0003724_increased_susceptibility_to0.89878898
64MP0008873_increased_physiological_sensi0.89128406
65MP0002102_abnormal_ear_morphology0.89047440
66MP0000604_amyloidosis0.87059491
67MP0003137_abnormal_impulse_conducting0.86337312
68MP0002163_abnormal_gland_morphology0.84241676
69MP0005623_abnormal_meninges_morphology0.81755535
70MP0009046_muscle_twitch0.81072342
71MP0005584_abnormal_enzyme/coenzyme_acti0.76881670
72MP0005166_decreased_susceptibility_to0.76577741
73MP0002019_abnormal_tumor_incidence0.75892754
74MP0002136_abnormal_kidney_physiology0.75292614
75MP0001502_abnormal_circadian_rhythm0.74906023
76MP0005310_abnormal_salivary_gland0.72580998
77MP0001986_abnormal_taste_sensitivity0.71731160
78MP0002693_abnormal_pancreas_physiology0.71409658
79MP0004142_abnormal_muscle_tone0.68425813
80MP0005075_abnormal_melanosome_morpholog0.67996535
81MP0001243_abnormal_dermal_layer0.64542886
82MP0005451_abnormal_body_composition0.64011874
83MP0002736_abnormal_nociception_after0.63587286
84MP0003300_gastrointestinal_ulcer0.63146652
85MP0005464_abnormal_platelet_physiology0.63060752
86MP0001765_abnormal_ion_homeostasis0.62745291
87MP0005636_abnormal_mineral_homeostasis0.60105366
88MP0001919_abnormal_reproductive_system0.59912045
89MP0002095_abnormal_skin_pigmentation0.57684719
90MP0000920_abnormal_myelination0.57516403
91MP0006072_abnormal_retinal_apoptosis0.54724770
92MP0002653_abnormal_ependyma_morphology0.54164396
93MP0004381_abnormal_hair_follicle0.51597335
94MP0009643_abnormal_urine_homeostasis0.49606537
95MP0008875_abnormal_xenobiotic_pharmacok0.49470791
96MP0002998_abnormal_bone_remodeling0.49157570
97MP0000681_abnormal_thyroid_gland0.47458543
98MP0004742_abnormal_vestibular_system0.45619471
99MP0005330_cardiomyopathy0.44644578
100MP0000678_abnormal_parathyroid_gland0.42902807

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.07162142
2Abnormality of T cell number (HP:0011839)7.29970289
3Autoimmune hemolytic anemia (HP:0001890)5.37513761
4Oral leukoplakia (HP:0002745)5.07333477
5Hypoproteinemia (HP:0003075)4.99358090
6Abnormality of T cells (HP:0002843)4.70979751
7Severe combined immunodeficiency (HP:0004430)4.58963795
8IgG deficiency (HP:0004315)4.34021575
9Abnormality of macrophages (HP:0004311)4.26852723
10Chronic diarrhea (HP:0002028)3.93411278
11Increased IgM level (HP:0003496)3.88352638
12Combined immunodeficiency (HP:0005387)3.87293528
13Neonatal respiratory distress (HP:0002643)3.30025151
14Recurrent viral infections (HP:0004429)3.06717089
15Pancytopenia (HP:0001876)2.98825279
16Thyroiditis (HP:0100646)2.97705261
17Hypoalbuminemia (HP:0003073)2.96965361
18Abnormal albumin level (HP:0012116)2.96965361
19Abnormality of eosinophils (HP:0001879)2.94134826
20Autoimmune thrombocytopenia (HP:0001973)2.93386899
21Hypoplasia of the uterus (HP:0000013)2.91601245
22Neuroendocrine neoplasm (HP:0100634)2.83842394
23Renal cortical cysts (HP:0000803)2.82356613
24Meningitis (HP:0001287)2.81605581
25Recurrent bronchitis (HP:0002837)2.80321193
26Encephalitis (HP:0002383)2.78343345
27Abnormality of the prostate (HP:0008775)2.75846387
28Lymphoma (HP:0002665)2.72920592
29Chronic obstructive pulmonary disease (HP:0006510)2.70127628
30Obstructive lung disease (HP:0006536)2.70127628
31Joint swelling (HP:0001386)2.69272177
32Recurrent cutaneous fungal infections (HP:0011370)2.68404868
33Chronic mucocutaneous candidiasis (HP:0002728)2.68404868
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.65984761
35Rough bone trabeculation (HP:0100670)2.63824475
36Aplasia/hypoplasia of the uterus (HP:0008684)2.62710876
37Recurrent fungal infections (HP:0002841)2.62528155
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.60982710
39Generalized aminoaciduria (HP:0002909)2.60392732
40Hemiplegia (HP:0002301)2.54614803
41Hypoplasia of the thymus (HP:0000778)2.52434820
42Granulocytopenia (HP:0001913)2.52227182
43Hepatocellular necrosis (HP:0001404)2.45223173
44Stomatitis (HP:0010280)2.42455074
45Lymphopenia (HP:0001888)2.37379642
46Eosinophilia (HP:0001880)2.37085455
47Elevated erythrocyte sedimentation rate (HP:0003565)2.36143367
48Cutaneous melanoma (HP:0012056)2.31513097
49Menstrual irregularities (HP:0000858)2.28888777
50Abnormal trabecular bone morphology (HP:0100671)2.28128638
51Symphalangism affecting the phalanges of the hand (HP:0009773)2.26215349
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.24862491
53Pheochromocytoma (HP:0002666)2.24418693
54IgM deficiency (HP:0002850)2.23941032
55Hypergammaglobulinemia (HP:0010702)2.22465388
56Abnormality of T cell physiology (HP:0011840)2.17344964
57Glucose intolerance (HP:0000833)2.16462123
58Leukocytosis (HP:0001974)2.15194202
59Hyponatremia (HP:0002902)2.11061923
60Abnormality of oral frenula (HP:0000190)2.11045881
61Dislocated radial head (HP:0003083)2.10666619
62Amniotic constriction ring (HP:0009775)2.06341198
63Abnormality of placental membranes (HP:0011409)2.06341198
64Abnormality of the radial head (HP:0003995)2.05753933
65Hepatic necrosis (HP:0002605)2.03424937
66Progressive inability to walk (HP:0002505)2.02278217
67Gangrene (HP:0100758)2.02084704
68Striae distensae (HP:0001065)2.01967588
69Acute hepatic failure (HP:0006554)2.01827536
70Progressive neurologic deterioration (HP:0002344)2.00730984
71Pulmonary fibrosis (HP:0002206)2.00636556
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00068169
73Aplastic anemia (HP:0001915)11.5191286
74Vasculitis (HP:0002633)1.98962190
75Abnormality of the costochondral junction (HP:0000919)1.98618142
76IgA deficiency (HP:0002720)1.97833509
77Pulmonary infiltrates (HP:0002113)1.94947668
78Hemoptysis (HP:0002105)1.94165516
79Agammaglobulinemia (HP:0004432)1.93945177
80Panhypogammaglobulinemia (HP:0003139)1.93053829
81Premature graying of hair (HP:0002216)1.92576696
82Abnormality of male internal genitalia (HP:0000022)1.91347805
83Bronchitis (HP:0012387)1.90140471
84Renal Fanconi syndrome (HP:0001994)1.89659990
85Ureteral stenosis (HP:0000071)1.85984093
86Chest pain (HP:0100749)1.85105788
87Nasolacrimal duct obstruction (HP:0000579)1.84476173
88Abnormality of the alveolar ridges (HP:0006477)1.83961312
89Fetal akinesia sequence (HP:0001989)1.82440737
90Mitochondrial inheritance (HP:0001427)1.78681632
91Rib fusion (HP:0000902)1.78598956
92Myositis (HP:0100614)1.77160474
93Abnormality of liposaccharide metabolism (HP:0010968)1.76811657
94Abnormality of glycosphingolipid metabolism (HP:0004343)1.76811657
95Abnormality of glycolipid metabolism (HP:0010969)1.76811657
96Abnormality of the humeroradial joint (HP:0100744)1.76321940
97Cellular immunodeficiency (HP:0005374)1.72931932
98Oligomenorrhea (HP:0000876)1.71459520
99Fibular aplasia (HP:0002990)1.71311906
100Pustule (HP:0200039)1.70178730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.86275596
2KDR5.17126485
3PIK3CA4.35006357
4ITK3.89046738
5TESK23.73864250
6MAP4K13.68987282
7BUB13.02345080
8FES2.21368047
9RIPK41.98337760
10MAPKAPK31.91107271
11MAP3K111.89453251
12TAOK31.87399484
13TESK11.75263523
14BCKDK1.66517889
15CSK1.65001650
16TYRO31.64470521
17SCYL21.61533740
18ZAP701.56459908
19SYK1.53085802
20TLK11.50097678
21LCK1.46598237
22TEC1.45229479
23PRKCQ1.44462822
24BMPR21.40500682
25MAP2K71.39540677
26ZAK1.38328677
27LYN1.35063742
28BTK1.31004677
29IKBKE1.20829614
30EIF2AK31.19694055
31VRK11.18166086
32LIMK11.18010856
33ACVR1B1.11767858
34MAP3K51.09818948
35TNK21.06541922
36JAK30.99672645
37ADRBK20.93494809
38FYN0.89449990
39PIM10.89239103
40BLK0.85059154
41MAP3K120.84203978
42MAP3K70.82577171
43MARK30.79650965
44GRK10.76988241
45TRPM70.74233848
46TYK20.70454297
47TAOK20.70271000
48IKBKB0.67195463
49STK160.65015240
50PRKD30.64504415
51KIT0.60664759
52CAMKK20.59755471
53PAK10.59098765
54ROCK10.58290651
55CAMK2A0.56836317
56MAPK110.56232083
57IGF1R0.55501729
58GRK60.54924874
59PASK0.54358456
60OBSCN0.51018464
61DAPK10.50877119
62CSF1R0.50839574
63FRK0.47998493
64TAOK10.47686785
65INSR0.47337615
66JAK20.47024451
67DAPK20.46525832
68INSRR0.46419696
69CAMKK10.45374353
70CAMK2D0.45132417
71PRKCH0.44509046
72PRKCA0.44104990
73NUAK10.43394579
74FGFR10.41712488
75MST40.38287807
76HCK0.37600594
77TBK10.36637183
78RPS6KA50.35963318
79ERBB30.35853332
80PRKCD0.35699290
81MAP2K60.35687533
82SRC0.35259000
83NEK90.34764270
84PIK3CG0.33920593
85NTRK30.33633722
86RET0.32475069
87MUSK0.31765210
88MAP3K30.31323110
89PRKCB0.31270457
90MYLK0.31200865
91PRKACA0.30310688
92MAP3K10.28236498
93PIM20.25507642
94ABL10.25441646
95CSNK2A10.24500726
96MAP4K20.24087967
97EGFR0.24079802
98STK100.23319162
99CHUK0.23041710
100MAPK120.20030383

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.20302118
2Primary immunodeficiency_Homo sapiens_hsa053405.10185870
3Antigen processing and presentation_Homo sapiens_hsa046124.23943115
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.22210297
5Autoimmune thyroid disease_Homo sapiens_hsa053203.58485583
6Allograft rejection_Homo sapiens_hsa053303.52263948
7Proteasome_Homo sapiens_hsa030503.40348768
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.06131285
9Hematopoietic cell lineage_Homo sapiens_hsa046402.84828912
10Type I diabetes mellitus_Homo sapiens_hsa049402.79148280
11T cell receptor signaling pathway_Homo sapiens_hsa046602.69300411
12Rheumatoid arthritis_Homo sapiens_hsa053232.37170712
13Salmonella infection_Homo sapiens_hsa051321.94454937
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.91349988
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.79223881
16Measles_Homo sapiens_hsa051621.79130611
17Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60034559
18Oxidative phosphorylation_Homo sapiens_hsa001901.59156923
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51037333
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45094112
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40344518
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38929691
23Malaria_Homo sapiens_hsa051441.29507514
24Viral myocarditis_Homo sapiens_hsa054161.25907008
25Fatty acid elongation_Homo sapiens_hsa000621.20750661
26Nitrogen metabolism_Homo sapiens_hsa009101.18585118
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10273101
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08176344
29Parkinsons disease_Homo sapiens_hsa050121.06924145
30RNA polymerase_Homo sapiens_hsa030201.05993739
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03460053
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01263085
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92623568
34Shigellosis_Homo sapiens_hsa051310.92306867
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90808027
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87449475
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.84848647
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83307929
39Asthma_Homo sapiens_hsa053100.82292776
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77127451
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.76444675
42Chemokine signaling pathway_Homo sapiens_hsa040620.73636281
43Alzheimers disease_Homo sapiens_hsa050100.73296202
44Linoleic acid metabolism_Homo sapiens_hsa005910.68087231
45Systemic lupus erythematosus_Homo sapiens_hsa053220.66618259
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66558220
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64767250
48Pertussis_Homo sapiens_hsa051330.64141773
49African trypanosomiasis_Homo sapiens_hsa051430.64128861
50Staphylococcus aureus infection_Homo sapiens_hsa051500.63435541
51Caffeine metabolism_Homo sapiens_hsa002320.62307274
52Protein export_Homo sapiens_hsa030600.62111924
53Cardiac muscle contraction_Homo sapiens_hsa042600.61068789
54Leishmaniasis_Homo sapiens_hsa051400.58495424
55Herpes simplex infection_Homo sapiens_hsa051680.58058800
56Legionellosis_Homo sapiens_hsa051340.55926488
57Apoptosis_Homo sapiens_hsa042100.55912244
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55236609
59N-Glycan biosynthesis_Homo sapiens_hsa005100.47875680
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.45226144
61Osteoclast differentiation_Homo sapiens_hsa043800.43516145
62Epstein-Barr virus infection_Homo sapiens_hsa051690.43502487
63Prion diseases_Homo sapiens_hsa050200.41861941
64Galactose metabolism_Homo sapiens_hsa000520.41272947
65Peroxisome_Homo sapiens_hsa041460.39300607
66Collecting duct acid secretion_Homo sapiens_hsa049660.37180345
67Influenza A_Homo sapiens_hsa051640.36557258
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34671498
69Regulation of autophagy_Homo sapiens_hsa041400.34259332
70Huntingtons disease_Homo sapiens_hsa050160.33580301
71ABC transporters_Homo sapiens_hsa020100.33221242
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32100801
73TNF signaling pathway_Homo sapiens_hsa046680.29061992
74Lysosome_Homo sapiens_hsa041420.28339440
75Phototransduction_Homo sapiens_hsa047440.25576965
76One carbon pool by folate_Homo sapiens_hsa006700.25068804
77Pyrimidine metabolism_Homo sapiens_hsa002400.23142309
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22345415
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19244138
80Tuberculosis_Homo sapiens_hsa051520.18253563
81Ether lipid metabolism_Homo sapiens_hsa005650.18201153
82Endocytosis_Homo sapiens_hsa041440.17946610
83Chemical carcinogenesis_Homo sapiens_hsa052040.17134807
84Mineral absorption_Homo sapiens_hsa049780.17001648
85Retinol metabolism_Homo sapiens_hsa008300.16924864
86Butanoate metabolism_Homo sapiens_hsa006500.16149735
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14192726
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13085469
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12244555
90Fatty acid metabolism_Homo sapiens_hsa012120.10482430
91Synaptic vesicle cycle_Homo sapiens_hsa047210.09978146
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09458660
93HTLV-I infection_Homo sapiens_hsa051660.09457572
94Olfactory transduction_Homo sapiens_hsa047400.05115925
95Phagosome_Homo sapiens_hsa041450.03627621
96Circadian rhythm_Homo sapiens_hsa047100.02861122
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.02111924
98Sulfur metabolism_Homo sapiens_hsa009200.01727938
99Fatty acid degradation_Homo sapiens_hsa000710.00853839
100Ribosome_Homo sapiens_hsa030100.00696643

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »