TRAJ54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA catabolic process (GO:0016075)6.71915235
2negative thymic T cell selection (GO:0045060)5.32055399
3positive regulation of gamma-delta T cell activation (GO:0046645)5.18146635
4T cell migration (GO:0072678)5.03581901
5negative T cell selection (GO:0043383)5.00291957
6positive regulation of B cell differentiation (GO:0045579)4.90187739
7positive regulation of alpha-beta T cell proliferation (GO:0046641)4.87541051
8maturation of 5.8S rRNA (GO:0000460)4.73325977
9sensory perception of taste (GO:0050909)4.59869335
10positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.58151682
11negative regulation of macrophage differentiation (GO:0045650)4.56708563
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.54987626
13positive regulation of natural killer cell mediated immunity (GO:0002717)4.51626159
14ribosomal small subunit assembly (GO:0000028)4.49969107
15thymic T cell selection (GO:0045061)4.49789323
16positive regulation of granulocyte differentiation (GO:0030854)4.46470913
17regulation of gamma-delta T cell differentiation (GO:0045586)4.42375581
18cell wall macromolecule metabolic process (GO:0044036)4.35554817
19mast cell activation (GO:0045576)4.26692998
20negative regulation of T cell apoptotic process (GO:0070233)4.24814839
21autophagic vacuole fusion (GO:0000046)4.19684272
22response to pheromone (GO:0019236)4.16401596
23regulation of alpha-beta T cell proliferation (GO:0046640)4.16205759
24DNA integration (GO:0015074)4.06211551
25regulation of posttranscriptional gene silencing (GO:0060147)4.02059473
26regulation of gene silencing by miRNA (GO:0060964)4.02059473
27regulation of gene silencing by RNA (GO:0060966)4.02059473
28positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.89270246
29detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.84413237
30positive regulation of chemokine secretion (GO:0090197)3.71837034
31positive thymic T cell selection (GO:0045059)3.70528081
32regulation of natural killer cell mediated immunity (GO:0002715)3.66283857
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.66283857
34response to interferon-beta (GO:0035456)3.65377323
35response to folic acid (GO:0051593)3.64283857
36regulation of gamma-delta T cell activation (GO:0046643)3.63512360
37peroxisome fission (GO:0016559)3.61775409
38sulfation (GO:0051923)3.57365803
39outer ear morphogenesis (GO:0042473)3.56989237
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.56112156
41cytokine biosynthetic process (GO:0042089)3.47711799
42regulation of isotype switching to IgG isotypes (GO:0048302)3.47333237
43viral transcription (GO:0019083)3.46534016
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46075036
45mature B cell differentiation involved in immune response (GO:0002313)3.41845408
46G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.38564600
47mast cell activation involved in immune response (GO:0002279)3.37853174
48mast cell degranulation (GO:0043303)3.37853174
49T cell costimulation (GO:0031295)3.35908113
50positive regulation of cell killing (GO:0031343)3.35753583
51ncRNA catabolic process (GO:0034661)3.35280928
52detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.33013069
53lymphocyte costimulation (GO:0031294)3.32454990
54regulation of chemokine secretion (GO:0090196)3.31185038
55positive regulation of interleukin-4 production (GO:0032753)3.29227978
56regulation of leukocyte mediated cytotoxicity (GO:0001910)3.28973114
57T cell receptor signaling pathway (GO:0050852)3.26619331
58T cell selection (GO:0045058)3.25772335
59regulation of B cell differentiation (GO:0045577)3.25068128
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23266439
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21330237
62regulation of B cell receptor signaling pathway (GO:0050855)3.21021501
63regulation of T cell tolerance induction (GO:0002664)3.20022522
64translational termination (GO:0006415)3.18101407
65regulation of secondary heart field cardioblast proliferation (GO:0003266)3.15259418
66regulation of cardioblast proliferation (GO:0003264)3.15259418
67positive regulation of interleukin-1 beta secretion (GO:0050718)3.13182463
68positive regulation of tolerance induction (GO:0002645)3.13052084
69negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.11975346
70production of molecular mediator involved in inflammatory response (GO:0002532)3.08886209
71translational elongation (GO:0006414)3.08122080
72negative regulation of thymocyte apoptotic process (GO:0070244)3.07689573
73positive regulation of calcium-mediated signaling (GO:0050850)3.07611145
74regulation of granulocyte differentiation (GO:0030852)3.05163020
75positive regulation of interleukin-1 secretion (GO:0050716)3.02633114
76cellular response to prostaglandin stimulus (GO:0071379)3.02135423
77cellular response to interleukin-15 (GO:0071350)3.00838115
78regulation of interleukin-2 biosynthetic process (GO:0045076)3.00127632
79positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99305235
80positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.98663453
81regulation of interleukin-4 production (GO:0032673)2.98181401
82regulation of triglyceride catabolic process (GO:0010896)2.96186300
83organelle membrane fusion (GO:0090174)2.94691455
84negative regulation of interleukin-17 production (GO:0032700)2.94360357
85cytokine metabolic process (GO:0042107)2.93868854
86negative regulation of T cell differentiation in thymus (GO:0033085)2.93175652
87negative regulation of gene silencing (GO:0060969)2.91512807
88negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.90336478
89SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89673769
90negative regulation of lipid storage (GO:0010888)2.88971677
91purine ribonucleotide transport (GO:0015868)2.88845680
92positive T cell selection (GO:0043368)2.88228825
93regulation of energy homeostasis (GO:2000505)2.87784214
94regulation of interleukin-1 beta secretion (GO:0050706)2.87435984
95cotranslational protein targeting to membrane (GO:0006613)2.86161390
96cellular response to exogenous dsRNA (GO:0071360)2.86021663
97protein localization to endoplasmic reticulum (GO:0070972)2.85700070
98protein targeting to ER (GO:0045047)2.83784630
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83770060
100regulation of antigen processing and presentation (GO:0002577)2.83418620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.70687561
2EZH2_22144423_ChIP-Seq_EOC_Human5.36292042
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.00046418
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.98057883
5NOTCH1_21737748_ChIP-Seq_TLL_Human4.29142335
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.12489165
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.03129907
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.63006760
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61906263
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37432975
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.84279310
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41644131
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.38872040
14IGF1R_20145208_ChIP-Seq_DFB_Human2.38251890
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27042054
16AR_21572438_ChIP-Seq_LNCaP_Human2.08097828
17RUNX_20019798_ChIP-Seq_JUKART_Human2.05373401
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95760614
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95573869
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90531985
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90531985
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90531985
23GATA3_27048872_Chip-Seq_THYMUS_Human1.85797136
24MYB_26560356_Chip-Seq_TH2_Human1.82605732
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81020859
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80321255
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59224848
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58307464
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51730182
30MYB_26560356_Chip-Seq_TH1_Human1.47257921
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44938838
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44570203
33UTX_26944678_Chip-Seq_JUKART_Human1.35744411
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34658027
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31535292
36GATA3_26560356_Chip-Seq_TH2_Human1.31027949
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24168404
38AR_20517297_ChIP-Seq_VCAP_Human1.22997917
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.19402512
40MAF_26560356_Chip-Seq_TH1_Human1.18474187
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14554179
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13572046
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.13401104
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12936765
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11631055
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11498801
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.10606846
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10476622
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.08976590
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08327394
51SOX2_21211035_ChIP-Seq_LN229_Human1.07810847
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07176534
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06410303
54ZNF274_21170338_ChIP-Seq_K562_Hela1.05551949
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05023266
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04972547
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04613680
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04377876
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02723801
60P300_19829295_ChIP-Seq_ESCs_Human1.01729285
61ERG_20517297_ChIP-Seq_VCAP_Human0.98535151
62WDR5_24793694_ChIP-Seq_LNCAP_Human0.95989424
63NANOG_20526341_ChIP-Seq_ESCs_Human0.95106415
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94487429
65ELK1_22589737_ChIP-Seq_MCF10A_Human0.91423059
66JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91386556
67GATA3_21867929_ChIP-Seq_TH1_Mouse0.90769508
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87920539
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87276259
70OCT4_20526341_ChIP-Seq_ESCs_Human0.87124554
71SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86742080
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86585456
73TP63_19390658_ChIP-ChIP_HaCaT_Human0.86174817
74SMRT_27268052_Chip-Seq_Bcells_Human0.85897615
75FOXH1_21741376_ChIP-Seq_EPCs_Human0.84575800
76KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84425903
77MYC_19829295_ChIP-Seq_ESCs_Human0.82838290
78MAF_26560356_Chip-Seq_TH2_Human0.81521168
79CTCF_20526341_ChIP-Seq_ESCs_Human0.81331545
80CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81173977
81CBX2_27304074_Chip-Seq_ESCs_Mouse0.80676237
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79683040
83NANOG_16153702_ChIP-ChIP_HESCs_Human0.78885203
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78314246
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77778309
86TAF2_19829295_ChIP-Seq_ESCs_Human0.76400080
87ER_23166858_ChIP-Seq_MCF-7_Human0.76135781
88STAT1_20625510_ChIP-Seq_HELA_Human0.75869249
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75848399
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.74183363
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73536406
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.73395786
93EZH2_27294783_Chip-Seq_ESCs_Mouse0.72699622
94VDR_23849224_ChIP-Seq_CD4+_Human0.72380503
95EST1_17652178_ChIP-ChIP_JURKAT_Human0.72145698
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72073065
97OCT4_19829295_ChIP-Seq_ESCs_Human0.71939890
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71797944
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.71707430
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.71480426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.76903936
2MP0003011_delayed_dark_adaptation4.03394452
3MP0002277_abnormal_respiratory_mucosa3.67860826
4MP0009785_altered_susceptibility_to3.58002443
5MP0003763_abnormal_thymus_physiology3.06045294
6MP0005451_abnormal_body_composition2.97416792
7MP0004885_abnormal_endolymph2.78385280
8MP0005503_abnormal_tendon_morphology2.67573635
9MP0004145_abnormal_muscle_electrophysio2.63122428
10MP0005000_abnormal_immune_tolerance2.42322495
11MP0002148_abnormal_hypersensitivity_rea2.36464977
12MP0001835_abnormal_antigen_presentation2.35056843
13MP0003878_abnormal_ear_physiology2.33181168
14MP0005377_hearing/vestibular/ear_phenot2.33181168
15MP0004381_abnormal_hair_follicle2.31400091
16MP0009840_abnormal_foam_cell2.29516491
17MP0003646_muscle_fatigue2.19863418
18MP0003191_abnormal_cellular_cholesterol2.18502470
19MP0003866_abnormal_defecation2.10057700
20MP0004947_skin_inflammation2.07207405
21MP0001800_abnormal_humoral_immune2.04504849
22MP0005025_abnormal_response_to2.02345057
23MP0010155_abnormal_intestine_physiology1.95764775
24MP0003183_abnormal_peptide_metabolism1.93356999
25MP0002723_abnormal_immune_serum1.89289080
26MP0002420_abnormal_adaptive_immunity1.84685665
27MP0002405_respiratory_system_inflammati1.84623696
28MP0003436_decreased_susceptibility_to1.79231993
29MP0002452_abnormal_antigen_presenting1.79044747
30MP0001819_abnormal_immune_cell1.74599236
31MP0009278_abnormal_bone_marrow1.73196911
32MP0005410_abnormal_fertilization1.72705689
33MP0000678_abnormal_parathyroid_gland1.68132751
34MP0000685_abnormal_immune_system1.64768781
35MP0008789_abnormal_olfactory_epithelium1.61188151
36MP0005645_abnormal_hypothalamus_physiol1.61182845
37MP0000716_abnormal_immune_system1.58104269
38MP0002419_abnormal_innate_immunity1.56810204
39MP0009053_abnormal_anal_canal1.54506848
40MP0001845_abnormal_inflammatory_respons1.50418912
41MP0003724_increased_susceptibility_to1.47494863
42MP0003195_calcinosis1.43408121
43MP0000703_abnormal_thymus_morphology1.39339208
44MP0005075_abnormal_melanosome_morpholog1.38356674
45MP0002398_abnormal_bone_marrow1.37058708
46MP0001790_abnormal_immune_system1.29572906
47MP0005387_immune_system_phenotype1.29572906
48MP0002722_abnormal_immune_system1.23373952
49MP0002138_abnormal_hepatobiliary_system1.21037499
50MP0003075_altered_response_to1.20874605
51MP0005499_abnormal_olfactory_system1.19208177
52MP0005394_taste/olfaction_phenotype1.19208177
53MP0005646_abnormal_pituitary_gland1.14118263
54MP0001243_abnormal_dermal_layer1.12279640
55MP0004270_analgesia1.11819256
56MP0003045_fibrosis1.11170543
57MP0000689_abnormal_spleen_morphology1.10342946
58MP0002998_abnormal_bone_remodeling1.08648461
59MP0005166_decreased_susceptibility_to1.08410859
60MP0002160_abnormal_reproductive_system1.08281119
61MP0009250_abnormal_appendicular_skeleto1.06571122
62MP0003879_abnormal_hair_cell1.02198803
63MP0002429_abnormal_blood_cell1.01847058
64MP0001765_abnormal_ion_homeostasis0.99521287
65MP0001853_heart_inflammation0.98476572
66MP0002693_abnormal_pancreas_physiology0.95804804
67MP0001533_abnormal_skeleton_physiology0.89992014
68MP0001963_abnormal_hearing_physiology0.89324092
69MP0002095_abnormal_skin_pigmentation0.88306440
70MP0005389_reproductive_system_phenotype0.85288838
71MP0004036_abnormal_muscle_relaxation0.82743821
72MP0008469_abnormal_protein_level0.79898385
73MP0000026_abnormal_inner_ear0.79322727
74MP0000537_abnormal_urethra_morphology0.78572854
75MP0005165_increased_susceptibility_to0.78557066
76MP0000049_abnormal_middle_ear0.78505000
77MP0000604_amyloidosis0.76914732
78MP0008961_abnormal_basal_metabolism0.76755040
79MP0001919_abnormal_reproductive_system0.76465828
80MP0002933_joint_inflammation0.75183792
81MP0002108_abnormal_muscle_morphology0.71434016
82MP0003448_altered_tumor_morphology0.69082303
83MP0008995_early_reproductive_senescence0.67613569
84MP0000490_abnormal_crypts_of0.66216543
85MP0004147_increased_porphyrin_level0.66109204
86MP0005408_hypopigmentation0.64454774
87MP0009763_increased_sensitivity_to0.64334782
88MP0005464_abnormal_platelet_physiology0.64199614
89MP0003279_aneurysm0.64101910
90MP0010386_abnormal_urinary_bladder0.61498406
91MP0005551_abnormal_eye_electrophysiolog0.59534442
92MP0002166_altered_tumor_susceptibility0.59223522
93MP0002019_abnormal_tumor_incidence0.58920231
94MP0001440_abnormal_grooming_behavior0.58918346
95MP0005448_abnormal_energy_balance0.57531717
96MP0005360_urolithiasis0.57257532
97MP0000538_abnormal_urinary_bladder0.56681739
98MP0000920_abnormal_myelination0.51832840
99MP0002734_abnormal_mechanical_nocicepti0.51704574
100MP0002127_abnormal_cardiovascular_syste0.50558596

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)6.04067961
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.31445929
3Aplastic anemia (HP:0001915)4.62932348
4Elevated erythrocyte sedimentation rate (HP:0003565)4.13131386
5T lymphocytopenia (HP:0005403)4.10300712
6Partial duplication of the phalanx of hand (HP:0009999)4.08894775
7Attenuation of retinal blood vessels (HP:0007843)4.00666062
8Severe combined immunodeficiency (HP:0004430)3.88210221
9Stomatitis (HP:0010280)3.71411898
10Type 2 muscle fiber atrophy (HP:0003554)3.54821706
11Abnormality of T cell number (HP:0011839)3.52025428
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.51353745
13Chronic bronchitis (HP:0004469)3.45788941
14Panhypogammaglobulinemia (HP:0003139)3.39118076
15Thyroiditis (HP:0100646)3.38278885
16Partial duplication of thumb phalanx (HP:0009944)3.29906249
17Chronic hepatic failure (HP:0100626)3.19497780
18Colitis (HP:0002583)3.15413136
19Hypoplasia of the thymus (HP:0000778)3.14054538
20Rectal fistula (HP:0100590)3.12782503
21Rectovaginal fistula (HP:0000143)3.12782503
22Increased hepatocellular lipid droplets (HP:0006565)3.06331986
23Combined immunodeficiency (HP:0005387)3.03635581
24Congenital stationary night blindness (HP:0007642)2.93452492
25Muscle fiber atrophy (HP:0100295)2.92886962
26Abnormality of the columella (HP:0009929)2.91946267
27IgG deficiency (HP:0004315)2.89434073
28Intestinal fistula (HP:0100819)2.87759763
293-Methylglutaconic aciduria (HP:0003535)2.84493557
30Global brain atrophy (HP:0002283)2.80899692
31Abnormality of DNA repair (HP:0003254)2.78961050
32Hypoproteinemia (HP:0003075)2.78117315
33Bronchitis (HP:0012387)2.72186957
34Acute necrotizing encephalopathy (HP:0006965)2.72156039
35Renal Fanconi syndrome (HP:0001994)2.71561507
36Pancreatic cysts (HP:0001737)2.69841701
37Vaginal fistula (HP:0004320)2.69258614
38Fibular aplasia (HP:0002990)2.68948740
39Lipid accumulation in hepatocytes (HP:0006561)2.67074941
40Exertional dyspnea (HP:0002875)2.63670152
41Chronic otitis media (HP:0000389)2.59074683
42Decreased central vision (HP:0007663)2.58829188
43Nasal polyposis (HP:0100582)2.53457473
44Inflammation of the large intestine (HP:0002037)2.50556235
45Increased intramyocellular lipid droplets (HP:0012240)2.48589407
46Long nose (HP:0003189)2.40159909
47Abnormal mitochondria in muscle tissue (HP:0008316)2.39404483
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.37308188
49Easy fatigability (HP:0003388)2.34817459
50Humeroradial synostosis (HP:0003041)2.34815760
51Synostosis involving the elbow (HP:0003938)2.34815760
52Abnormal respiratory motile cilium physiology (HP:0012261)2.32712509
53Progressive macrocephaly (HP:0004481)2.31874279
54Entropion (HP:0000621)2.31622032
55Congenital sensorineural hearing impairment (HP:0008527)2.31160059
56Increased muscle lipid content (HP:0009058)2.30182648
57Mitochondrial inheritance (HP:0001427)2.25341402
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24318717
59Fatigable weakness (HP:0003473)2.23898324
60Abnormality of the neuromuscular junction (HP:0003398)2.23898324
61Rhinitis (HP:0012384)2.21825515
62Recurrent bronchitis (HP:0002837)2.21585593
63Gastrointestinal inflammation (HP:0004386)2.20725466
64Poikiloderma (HP:0001029)2.19746893
65Bronchiectasis (HP:0002110)2.18675570
66Anomalous pulmonary venous return (HP:0010772)2.16850903
67Abnormality of the parietal bone (HP:0002696)2.14497550
68Elfin facies (HP:0004428)2.13672147
69Abnormality of T cells (HP:0002843)2.13611678
70Nonprogressive disorder (HP:0003680)2.13262938
71Asplenia (HP:0001746)2.12335724
72Abnormality of the nasal mucosa (HP:0000433)2.09740009
73Azoospermia (HP:0000027)2.07471006
74Anhidrosis (HP:0000970)2.06825617
75Recurrent otitis media (HP:0000403)2.04627270
76Thrombocytosis (HP:0001894)2.02036109
77Agammaglobulinemia (HP:0004432)1.99461619
78Hypothermia (HP:0002045)1.96790716
79B lymphocytopenia (HP:0010976)1.95454314
80Radial bowing (HP:0002986)1.95053359
81Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94557809
82Abnormality of the pulmonary veins (HP:0011718)1.94015198
83Abnormal rod and cone electroretinograms (HP:0008323)1.92667108
84Autoimmune hemolytic anemia (HP:0001890)1.92134826
85Recurrent fungal infections (HP:0002841)1.91337773
86Renovascular hypertension (HP:0100817)1.90001734
87True hermaphroditism (HP:0010459)1.88904451
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.88739730
89Symphalangism affecting the phalanges of the hand (HP:0009773)1.87741036
90Abnormality of the diencephalon (HP:0010662)1.87051316
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.86868860
92Aplasia of the musculature (HP:0100854)1.86357831
93Absent thumb (HP:0009777)1.86294587
94Chronic mucocutaneous candidiasis (HP:0002728)1.85649554
95Recurrent cutaneous fungal infections (HP:0011370)1.85649554
96Abnormality of B cell number (HP:0010975)1.84209413
97Hypoplastic left heart (HP:0004383)1.82469292
98Pancreatic fibrosis (HP:0100732)1.81778619
99Leukocytosis (HP:0001974)1.79833768
100Reduced antithrombin III activity (HP:0001976)1.78663875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK8.34876597
2TESK28.04214283
3PASK4.47833989
4RIPK13.28902226
5SCYL22.81245643
6TXK2.74683901
7PIK3CG2.45208660
8MAP3K102.43547337
9CAMKK12.39783381
10KDR2.36645798
11IKBKE1.93825288
12EIF2AK11.81337427
13EIF2AK31.74056952
14ZAP701.52508093
15FES1.49711415
16TBK11.39376290
17NME11.38795557
18ITK1.31365898
19LIMK11.29794085
20CDK191.27010377
21MAP4K11.16069165
22CAMKK21.07374599
23TYRO31.05086779
24NLK0.98474673
25TESK10.97597833
26MAP3K90.95907327
27MARK30.95817518
28SYK0.95800925
29FRK0.87344434
30PDGFRB0.80374693
31CSK0.80130860
32NEK60.79902068
33GRK60.77306361
34IKBKB0.75816058
35OBSCN0.71676004
36BLK0.71455659
37PAK10.71446138
38LCK0.70783413
39MAP2K70.68895499
40TYK20.68553304
41TRIB30.68347824
42KIT0.67418615
43BTK0.67365080
44BUB10.66830832
45ADRBK20.64552456
46LYN0.56147488
47TEC0.55996558
48CDK80.54165484
49CDC42BPA0.54100036
50MAPK150.52858149
51RIPK40.51382644
52IGF1R0.50860154
53INSRR0.49260184
54FYN0.48951756
55PDK10.47857454
56RPS6KC10.46570022
57RPS6KL10.46570022
58RPS6KA60.45021577
59JAK30.44432855
60IRAK40.42758065
61PAK30.42587446
62EPHA40.39737898
63MAPK40.39060412
64IRAK20.38890313
65PIM20.38124396
66PIM10.37209854
67VRK10.36842882
68RPS6KA20.36658761
69STK110.35271082
70CDK60.35007062
71TNK20.33797156
72MAP4K20.32874304
73HCK0.32679699
74MAP2K60.31482922
75MAP3K70.30683301
76PDPK10.28665634
77FGFR20.28502901
78NME20.28426197
79ACVR1B0.25983850
80PRKCQ0.25143438
81GRK10.24581347
82MAP3K130.24480100
83ADRBK10.23353876
84TIE10.23150543
85IRAK10.22444213
86CSF1R0.21629981
87GRK70.21159305
88PRKCB0.20573252
89ROCK10.20478922
90PRKCA0.19840475
91EGFR0.19254466
92CHUK0.19225258
93PRKCH0.18666825
94MAP3K80.17736143
95STK100.17409696
96CDK40.17366902
97ERBB20.16783959
98LRRK20.15850450
99RPS6KB10.14823783
100NTRK30.14195894

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.06519495
2Ribosome_Homo sapiens_hsa030103.37792216
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.96735818
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.75391745
5Hematopoietic cell lineage_Homo sapiens_hsa046402.59915903
6Phototransduction_Homo sapiens_hsa047442.31269709
7Oxidative phosphorylation_Homo sapiens_hsa001902.26321744
8Taste transduction_Homo sapiens_hsa047422.22514647
9T cell receptor signaling pathway_Homo sapiens_hsa046602.10286741
10Collecting duct acid secretion_Homo sapiens_hsa049662.05628476
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.05475117
12RNA degradation_Homo sapiens_hsa030181.91623030
13Nucleotide excision repair_Homo sapiens_hsa034201.89025997
14Nitrogen metabolism_Homo sapiens_hsa009101.86919101
15Graft-versus-host disease_Homo sapiens_hsa053321.76113551
16Olfactory transduction_Homo sapiens_hsa047401.73464588
17Antigen processing and presentation_Homo sapiens_hsa046121.64611550
18Autoimmune thyroid disease_Homo sapiens_hsa053201.64231160
19Allograft rejection_Homo sapiens_hsa053301.61567391
20Measles_Homo sapiens_hsa051621.58481310
21Rheumatoid arthritis_Homo sapiens_hsa053231.50037274
22Malaria_Homo sapiens_hsa051441.49562253
23Systemic lupus erythematosus_Homo sapiens_hsa053221.38306428
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37927704
25Type I diabetes mellitus_Homo sapiens_hsa049401.37639302
26Retinol metabolism_Homo sapiens_hsa008301.32342766
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.25889959
28Parkinsons disease_Homo sapiens_hsa050121.20125838
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15551494
30Linoleic acid metabolism_Homo sapiens_hsa005911.11508579
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10869149
32Morphine addiction_Homo sapiens_hsa050321.09095658
33Cardiac muscle contraction_Homo sapiens_hsa042601.07768298
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05457538
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02851985
36Pertussis_Homo sapiens_hsa051331.02748889
37Circadian entrainment_Homo sapiens_hsa047131.02100379
38Jak-STAT signaling pathway_Homo sapiens_hsa046300.99923328
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.99260782
40Protein export_Homo sapiens_hsa030600.98993707
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98698089
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96408701
43Cholinergic synapse_Homo sapiens_hsa047250.90804387
44DNA replication_Homo sapiens_hsa030300.90541527
45Alcoholism_Homo sapiens_hsa050340.90399684
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89939291
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88833100
48Glutamatergic synapse_Homo sapiens_hsa047240.86757822
49Viral myocarditis_Homo sapiens_hsa054160.86114224
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85937803
51B cell receptor signaling pathway_Homo sapiens_hsa046620.85832512
52Renin secretion_Homo sapiens_hsa049240.85577505
53Alzheimers disease_Homo sapiens_hsa050100.84779901
54GABAergic synapse_Homo sapiens_hsa047270.83015282
55Staphylococcus aureus infection_Homo sapiens_hsa051500.77266406
56Arachidonic acid metabolism_Homo sapiens_hsa005900.77041022
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76606636
58Serotonergic synapse_Homo sapiens_hsa047260.71945387
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68016208
60Ras signaling pathway_Homo sapiens_hsa040140.67117231
61ABC transporters_Homo sapiens_hsa020100.65908865
62Butanoate metabolism_Homo sapiens_hsa006500.65466095
63Pyruvate metabolism_Homo sapiens_hsa006200.65192889
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63623406
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.63053530
66Legionellosis_Homo sapiens_hsa051340.63006472
67Osteoclast differentiation_Homo sapiens_hsa043800.57979926
68Nicotine addiction_Homo sapiens_hsa050330.56723654
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55941213
70Synaptic vesicle cycle_Homo sapiens_hsa047210.54787389
71Type II diabetes mellitus_Homo sapiens_hsa049300.54247401
72Chemokine signaling pathway_Homo sapiens_hsa040620.53898984
73Herpes simplex infection_Homo sapiens_hsa051680.53193878
74Peroxisome_Homo sapiens_hsa041460.52936790
75Platelet activation_Homo sapiens_hsa046110.52506139
76Glycerolipid metabolism_Homo sapiens_hsa005610.51541227
77Salmonella infection_Homo sapiens_hsa051320.50315424
78Basal transcription factors_Homo sapiens_hsa030220.43365331
79Asthma_Homo sapiens_hsa053100.41783990
80Other glycan degradation_Homo sapiens_hsa005110.41203820
81Oxytocin signaling pathway_Homo sapiens_hsa049210.41036339
82Ovarian steroidogenesis_Homo sapiens_hsa049130.40809773
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40233850
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.40167235
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37509621
86cAMP signaling pathway_Homo sapiens_hsa040240.36364805
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36131164
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34107066
89Phagosome_Homo sapiens_hsa041450.32650964
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31931794
91Salivary secretion_Homo sapiens_hsa049700.29587348
92Influenza A_Homo sapiens_hsa051640.28975878
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28134689
94Dopaminergic synapse_Homo sapiens_hsa047280.26282445
95Fat digestion and absorption_Homo sapiens_hsa049750.25244149
96Rap1 signaling pathway_Homo sapiens_hsa040150.25237495
97Amphetamine addiction_Homo sapiens_hsa050310.24024197
98Shigellosis_Homo sapiens_hsa051310.23793870
99Dilated cardiomyopathy_Homo sapiens_hsa054140.23480987
100Huntingtons disease_Homo sapiens_hsa050160.23124960

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