TRAJ59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cell cycle G2/M phase transition (GO:1902751)9.38208012
2positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)9.38208012
3positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)9.23686297
4glycine transport (GO:0015816)8.94736193
5positive regulation of DNA-templated transcription, initiation (GO:2000144)8.12319198
6response to water (GO:0009415)7.94896583
7positive regulation of fibroblast migration (GO:0010763)7.88863141
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)7.54656538
9hematopoietic stem cell proliferation (GO:0071425)7.47384418
10regulation of hair follicle development (GO:0051797)7.40128265
11detection of calcium ion (GO:0005513)7.36075811
12L-amino acid import (GO:0043092)7.28088220
13NAD biosynthetic process (GO:0009435)7.23885319
14inner ear receptor cell development (GO:0060119)6.44662424
15centriole assembly (GO:0098534)6.42681492
16superoxide anion generation (GO:0042554)6.31028357
17regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)5.99737683
18pyridine nucleotide biosynthetic process (GO:0019363)5.88476594
19nicotinamide nucleotide biosynthetic process (GO:0019359)5.88476594
20reflex (GO:0060004)5.79798107
21exogenous drug catabolic process (GO:0042738)5.78636513
22skeletal muscle fiber development (GO:0048741)5.75168619
23amino acid import (GO:0043090)5.59835333
24regulation of nuclear cell cycle DNA replication (GO:0033262)5.28469397
25cellular response to vitamin D (GO:0071305)5.18210210
26cellular response to hepatocyte growth factor stimulus (GO:0035729)5.17555659
27response to hepatocyte growth factor (GO:0035728)5.17555659
28regulation of DNA-templated transcription, initiation (GO:2000142)4.99673878
29pyridine-containing compound biosynthetic process (GO:0072525)4.89809431
30response to lipoprotein particle (GO:0055094)4.83035117
31regulation of hair cycle (GO:0042634)4.78023250
32myoblast differentiation (GO:0045445)4.77502547
33myotube cell development (GO:0014904)4.75127832
34drug catabolic process (GO:0042737)4.71408499
35regulation of RIG-I signaling pathway (GO:0039535)4.41044379
36response to gravity (GO:0009629)4.40079190
37detection of mechanical stimulus involved in sensory perception (GO:0050974)4.31102883
38skeletal muscle contraction (GO:0003009)4.27923599
39chemosensory behavior (GO:0007635)4.06562430
40SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.94957935
41phosphorelay signal transduction system (GO:0000160)3.81217627
42neurotransmitter biosynthetic process (GO:0042136)3.80968790
43trabecula formation (GO:0060343)3.80297959
44regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.70631070
45cAMP catabolic process (GO:0006198)3.64665048
46NAD metabolic process (GO:0019674)3.64026680
47RNA-dependent DNA replication (GO:0006278)3.59529945
48cellular response to vitamin (GO:0071295)3.57950393
49sensory perception of taste (GO:0050909)3.57390138
50homocysteine metabolic process (GO:0050667)3.55805895
51positive regulation of osteoblast proliferation (GO:0033690)3.52228635
52diacylglycerol metabolic process (GO:0046339)3.50094653
53regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.48938119
54positive regulation of calcium ion import (GO:0090280)3.44308205
55telomere maintenance via telomerase (GO:0007004)3.36282848
56DNA integration (GO:0015074)3.34199291
57positive regulation of epidermis development (GO:0045684)3.34198078
58positive regulation of DNA-dependent DNA replication (GO:2000105)3.31668721
59cyclic nucleotide catabolic process (GO:0009214)3.25725010
60negative regulation of myoblast differentiation (GO:0045662)3.24813897
61regulation of cell cycle G2/M phase transition (GO:1902749)3.22611550
62superoxide metabolic process (GO:0006801)3.19776964
63positive regulation of response to biotic stimulus (GO:0002833)3.13591747
64regulation of synapse maturation (GO:0090128)3.09360997
65detection of mechanical stimulus (GO:0050982)3.08615409
66negative regulation of protein localization to cell surface (GO:2000009)3.01640637
67multicellular organism reproduction (GO:0032504)3.00664523
68protein localization to microtubule (GO:0035372)2.97938951
69arginine catabolic process (GO:0006527)2.96081028
70photoreceptor cell differentiation (GO:0046530)2.94562560
71eye photoreceptor cell differentiation (GO:0001754)2.94562560
72activated T cell proliferation (GO:0050798)2.92955985
73regulation of fibroblast migration (GO:0010762)2.90727216
74chondrocyte differentiation (GO:0002062)2.90626264
75glomerulus development (GO:0032835)2.88407234
76negative regulation of DNA-dependent DNA replication (GO:2000104)2.88095344
77tryptophan metabolic process (GO:0006568)2.84382632
78kynurenine metabolic process (GO:0070189)2.84268714
79positive regulation of bone mineralization (GO:0030501)2.79041948
80nephron tubule formation (GO:0072079)2.75464461
81cellular response to cAMP (GO:0071320)2.75355939
82lysine catabolic process (GO:0006554)2.72694844
83lysine metabolic process (GO:0006553)2.72694844
84tryptophan catabolic process (GO:0006569)2.72519269
85indole-containing compound catabolic process (GO:0042436)2.72519269
86indolalkylamine catabolic process (GO:0046218)2.72519269
87inositol phosphate-mediated signaling (GO:0048016)2.71074561
88meiotic chromosome segregation (GO:0045132)2.69472754
89negative regulation of neurotransmitter transport (GO:0051589)2.64918368
90negative regulation of calcium ion transport into cytosol (GO:0010523)2.63720162
91ruffle organization (GO:0031529)2.61754397
92positive regulation of mitotic cell cycle phase transition (GO:1901992)2.61186717
93negative regulation of telomere maintenance (GO:0032205)2.59339935
94positive regulation of cell cycle phase transition (GO:1901989)2.58934682
95positive regulation of biomineral tissue development (GO:0070169)2.57388295
96detection of chemical stimulus (GO:0009593)2.55833004
97bone trabecula formation (GO:0060346)12.0442059
98response to parathyroid hormone (GO:0071107)11.6227649
99positive regulation of hair cycle (GO:0042635)10.5774500
100positive regulation of hair follicle development (GO:0051798)10.5774500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.08025751
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.55148160
3GBX2_23144817_ChIP-Seq_PC3_Human3.27368601
4EZH2_22144423_ChIP-Seq_EOC_Human2.87362815
5PCGF2_27294783_Chip-Seq_NPCs_Mouse2.59123874
6SUZ12_27294783_Chip-Seq_NPCs_Mouse2.37577056
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22272188
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.19403431
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17605247
10NFE2_27457419_Chip-Seq_LIVER_Mouse2.07613169
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01293261
12EZH2_27294783_Chip-Seq_NPCs_Mouse1.98897040
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93980125
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85504673
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74710307
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73564101
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73564101
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72563479
19EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72214074
20DROSHA_22980978_ChIP-Seq_HELA_Human1.71358472
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.70487349
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70204727
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66924075
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66110538
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65840951
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.65805282
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.64414987
28IRF1_19129219_ChIP-ChIP_H3396_Human1.62931469
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.61378322
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61206778
31STAT3_18555785_Chip-Seq_ESCs_Mouse1.58515805
32P53_22387025_ChIP-Seq_ESCs_Mouse1.58188551
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57550640
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.57496918
35CMYC_18555785_Chip-Seq_ESCs_Mouse1.52532304
36SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51903230
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51831685
38NMYC_18555785_Chip-Seq_ESCs_Mouse1.50952284
39E2F1_18555785_Chip-Seq_ESCs_Mouse1.50942926
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47981993
41EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.45197595
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44500260
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43035076
44PU1_27457419_Chip-Seq_LIVER_Mouse1.42376451
45SOX2_18555785_Chip-Seq_ESCs_Mouse1.41548447
46CRX_20693478_ChIP-Seq_RETINA_Mouse1.41147304
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41061787
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40772351
49SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.40303946
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.39707123
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.32865341
52P300_18555785_Chip-Seq_ESCs_Mouse1.32273768
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31030080
54CTCF_18555785_Chip-Seq_ESCs_Mouse1.30655273
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30185048
56HTT_18923047_ChIP-ChIP_STHdh_Human1.28564839
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27268035
58RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27013141
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.26207321
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25337581
61KDM2B_26808549_Chip-Seq_REH_Human1.24401487
62KLF4_18555785_Chip-Seq_ESCs_Mouse1.23893974
63SMAD1_18555785_Chip-Seq_ESCs_Mouse1.22806731
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22479209
65ZFX_18555785_Chip-Seq_ESCs_Mouse1.21401017
66ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21108539
67LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17432097
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17414262
69ELK4_26923725_Chip-Seq_MESODERM_Mouse1.17193380
70REST_21632747_ChIP-Seq_MESCs_Mouse1.17159488
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15742957
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.14860106
73STAT3_23295773_ChIP-Seq_U87_Human1.09683921
74TP53_18474530_ChIP-ChIP_U2OS_Human1.06813685
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.06158145
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06081771
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.03995924
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.03141912
79GF1_26923725_Chip-Seq_HPCs_Mouse1.00447873
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00403755
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00313752
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99239606
83RNF2_27304074_Chip-Seq_ESCs_Mouse0.98627873
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95751030
85SMAD3_21741376_ChIP-Seq_EPCs_Human0.95439717
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94716319
87SMAD4_21799915_ChIP-Seq_A2780_Human0.94256885
88RUNX2_22187159_ChIP-Seq_PCA_Human0.94114750
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94051501
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93854034
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93432477
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.93238277
93TBL1_22424771_ChIP-Seq_293T_Human0.92439378
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91426318
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91005923
96IRF8_27001747_Chip-Seq_BMDM_Mouse0.90303228
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90076746
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89931069
99TCF4_23295773_ChIP-Seq_U87_Human0.89500224
100AHR_22903824_ChIP-Seq_MCF-7_Human0.86810253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology8.49739961
2MP0003195_calcinosis8.10894393
3MP0001188_hyperpigmentation3.54595293
4MP0000750_abnormal_muscle_regeneration3.23587706
5MP0009384_cardiac_valve_regurgitation3.11748981
6MP0005451_abnormal_body_composition2.97642314
7MP0004484_altered_response_of2.80348959
8MP0008057_abnormal_DNA_replication2.59880374
9MP0006072_abnormal_retinal_apoptosis2.55600468
10MP0004142_abnormal_muscle_tone2.52068666
11MP0004782_abnormal_surfactant_physiolog2.48366758
12MP0005410_abnormal_fertilization2.48101827
13MP0000678_abnormal_parathyroid_gland2.45591080
14MP0009764_decreased_sensitivity_to2.30523963
15MP0000579_abnormal_nail_morphology2.28902829
16MP0003283_abnormal_digestive_organ2.28736501
17MP0003646_muscle_fatigue2.25698229
18MP0005623_abnormal_meninges_morphology2.20136309
19MP0003941_abnormal_skin_development2.19347863
20MP0010386_abnormal_urinary_bladder2.16455235
21MP0004858_abnormal_nervous_system2.11279459
22MP0002168_other_aberrant_phenotype1.99845088
23MP0005645_abnormal_hypothalamus_physiol1.91691107
24MP0009785_altered_susceptibility_to1.83872737
25MP0004742_abnormal_vestibular_system1.83280760
26MP0002736_abnormal_nociception_after1.79945184
27MP0005167_abnormal_blood-brain_barrier1.79648189
28MP0001486_abnormal_startle_reflex1.69018659
29MP0009697_abnormal_copulation1.66154869
30MP0002876_abnormal_thyroid_physiology1.65442187
31MP0005165_increased_susceptibility_to1.50015206
32MP0003122_maternal_imprinting1.47933736
33MP0001501_abnormal_sleep_pattern1.44939116
34MP0004859_abnormal_synaptic_plasticity1.33992105
35MP0002108_abnormal_muscle_morphology1.31062249
36MP0004043_abnormal_pH_regulation1.29657530
37MP0000733_abnormal_muscle_development1.29603656
38MP0000383_abnormal_hair_follicle1.27315660
39MP0003123_paternal_imprinting1.26059316
40MP0010678_abnormal_skin_adnexa1.18289535
41MP0003045_fibrosis1.12680989
42MP0005085_abnormal_gallbladder_physiolo1.11505084
43MP0001968_abnormal_touch/_nociception1.11480605
44MP0000490_abnormal_crypts_of1.06404877
45MP0009745_abnormal_behavioral_response1.02145555
46MP0002896_abnormal_bone_mineralization1.00372713
47MP0003121_genomic_imprinting0.97997392
48MP0001502_abnormal_circadian_rhythm0.97496232
49MP0001440_abnormal_grooming_behavior0.96969952
50MP0002067_abnormal_sensory_capabilities0.95537863
51MP0008874_decreased_physiological_sensi0.93355196
52MP0003075_altered_response_to0.92088065
53MP0003635_abnormal_synaptic_transmissio0.91695250
54MP0004019_abnormal_vitamin_homeostasis0.89832913
55MP0005253_abnormal_eye_physiology0.89450090
56MP0005387_immune_system_phenotype0.89109618
57MP0001790_abnormal_immune_system0.89109618
58MP0003191_abnormal_cellular_cholesterol0.88332569
59MP0002139_abnormal_hepatobiliary_system0.87662390
60MP0002419_abnormal_innate_immunity0.85253805
61MP0005369_muscle_phenotype0.84706494
62MP0005395_other_phenotype0.78061290
63MP0002184_abnormal_innervation0.70660232
64MP0002396_abnormal_hematopoietic_system0.70316654
65MP0005360_urolithiasis0.68804670
66MP0002557_abnormal_social/conspecific_i0.68319981
67MP0005166_decreased_susceptibility_to0.68134181
68MP0008775_abnormal_heart_ventricle0.66962562
69MP0003566_abnormal_cell_adhesion0.66303788
70MP0001919_abnormal_reproductive_system0.65866384
71MP0002148_abnormal_hypersensitivity_rea0.65066188
72MP0008260_abnormal_autophagy0.64129835
73MP0002064_seizures0.63545065
74MP0010234_abnormal_vibrissa_follicle0.60630816
75MP0000427_abnormal_hair_cycle0.58841221
76MP0001958_emphysema0.58328223
77MP0000026_abnormal_inner_ear0.58229136
78MP0005083_abnormal_biliary_tract0.58148569
79MP0005551_abnormal_eye_electrophysiolog0.56320039
80MP0009046_muscle_twitch0.55819337
81MP0000767_abnormal_smooth_muscle0.55677243
82MP0001533_abnormal_skeleton_physiology0.55261026
83MP0005171_absent_coat_pigmentation0.53611774
84MP0005025_abnormal_response_to0.53380875
85MP0003436_decreased_susceptibility_to0.51273620
86MP0001845_abnormal_inflammatory_respons0.50402002
87MP0010155_abnormal_intestine_physiology0.48830237
88MP0001177_atelectasis0.48575940
89MP0000516_abnormal_urinary_system0.47311796
90MP0005367_renal/urinary_system_phenotyp0.47311796
91MP0001963_abnormal_hearing_physiology0.47285043
92MP0008872_abnormal_physiological_respon0.47141175
93MP0002723_abnormal_immune_serum0.46967745
94MP0002452_abnormal_antigen_presenting0.45369590
95MP0005647_abnormal_sex_gland0.45347034
96MP0005535_abnormal_body_temperature0.45118935
97MP0003011_delayed_dark_adaptation0.45116459
98MP0002063_abnormal_learning/memory/cond0.44619046
99MP0001800_abnormal_humoral_immune0.44394239
100MP0004133_heterotaxia0.43950183

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)9.31107779
2Oligodactyly (HP:0012165)7.87999310
3Absent hand (HP:0004050)7.46898799
4Pendular nystagmus (HP:0012043)7.06614548
5Abnormality of macular pigmentation (HP:0008002)6.43249094
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.60198351
7Increased circulating renin level (HP:0000848)5.06738227
8Severe Myopia (HP:0011003)4.75175655
9Agitation (HP:0000713)4.66739362
10Horizontal nystagmus (HP:0000666)3.95058172
11Alveolar cell carcinoma (HP:0006519)3.91117040
12Mesangial abnormality (HP:0001966)3.91015306
13Hypomagnesemia (HP:0002917)3.77606587
14Tetany (HP:0001281)3.62937364
15Striae distensae (HP:0001065)3.60682700
16Abnormality of abdominal situs (HP:0011620)3.54279286
17Abdominal situs inversus (HP:0003363)3.54279286
18Neoplasm of the tracheobronchial system (HP:0100552)3.51726866
19Hyperphosphatemia (HP:0002905)3.41813798
20Resting tremor (HP:0002322)3.19734035
21Muscle stiffness (HP:0003552)3.16029451
22Hypercortisolism (HP:0001578)3.13511254
23Retrobulbar optic neuritis (HP:0100654)3.12905070
24Optic neuritis (HP:0100653)3.12905070
25Abnormality of magnesium homeostasis (HP:0004921)3.00484093
26Mesomelia (HP:0003027)2.93722530
27Akinesia (HP:0002304)2.76364634
28Abnormality of calcium-phosphate metabolism (HP:0100530)2.75587731
29Orchitis (HP:0100796)2.75333471
30Polydipsia (HP:0001959)2.69910690
31Abnormal drinking behavior (HP:0030082)2.69910690
32Depression (HP:0000716)2.68069844
33Metaphyseal irregularity (HP:0003025)2.60775912
34Absent toe (HP:0010760)2.58151374
35Macular degeneration (HP:0000608)2.51806048
36Abnormality of renin-angiotensin system (HP:0000847)2.47464555
37Restlessness (HP:0000711)2.45579285
38Generalized myoclonic seizures (HP:0002123)2.43699599
39Type 2 muscle fiber atrophy (HP:0003554)2.35763576
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33344595
41Anxiety (HP:0000739)2.29093531
42Incomplete penetrance (HP:0003829)2.27034057
43Neonatal respiratory distress (HP:0002643)2.26200869
44Basal ganglia calcification (HP:0002135)2.25821661
45Erythroderma (HP:0001019)2.25229527
46Congenital ichthyosiform erythroderma (HP:0007431)2.25190860
47Myositis (HP:0100614)2.22460642
48Hypoplasia of the thymus (HP:0000778)2.17495814
49Distal lower limb amyotrophy (HP:0008944)2.08031269
50Abnormality of B cell number (HP:0010975)2.04667797
51B lymphocytopenia (HP:0010976)2.04667797
52Lack of skin elasticity (HP:0100679)2.03996168
53Muscle fiber atrophy (HP:0100295)2.01803846
54Split foot (HP:0001839)11.5242086
55Oligodactyly (hands) (HP:0001180)11.2671677
56Hypophosphatemia (HP:0002148)1.99648413
57Reduced antithrombin III activity (HP:0001976)1.98279131
58Tachypnea (HP:0002789)1.97842471
59Split hand (HP:0001171)1.97119539
60Distal lower limb muscle weakness (HP:0009053)1.93155223
61Lower limb amyotrophy (HP:0007210)1.92628602
62Hyperparathyroidism (HP:0000843)1.92318739
63Generalized tonic-clonic seizures (HP:0002069)1.90502656
64Neurodegeneration (HP:0002180)1.89459725
65Keratoconjunctivitis sicca (HP:0001097)1.88465946
66Fatigable weakness (HP:0003473)1.83970927
67Abnormality of the neuromuscular junction (HP:0003398)1.83970927
68Focal segmental glomerulosclerosis (HP:0000097)1.82188639
69Recurrent gram-negative bacterial infections (HP:0005420)1.80918295
70Poor suck (HP:0002033)1.80852992
71Intellectual disability, moderate (HP:0002342)1.78551000
72Abnormal urine phosphate concentration (HP:0012599)1.77331067
73Status epilepticus (HP:0002133)1.76322324
74Truncal obesity (HP:0001956)1.75866650
75Gangrene (HP:0100758)1.74755167
76Transposition of the great arteries (HP:0001669)1.73964094
77Abnormal connection of the cardiac segments (HP:0011545)1.73964094
78Abnormal ventriculo-arterial connection (HP:0011563)1.73964094
79Steatorrhea (HP:0002570)1.73506165
80Pancreatitis (HP:0001733)1.73386650
81Respiratory distress (HP:0002098)1.72305469
82Abnormality of the intrinsic pathway (HP:0010989)1.72022550
83Childhood onset (HP:0011463)1.68232007
84Eosinophilia (HP:0001880)1.68022889
85Keratoconjunctivitis (HP:0001096)1.64467379
86Facial cleft (HP:0002006)1.63027725
87Conical tooth (HP:0000698)1.62700685
88Postural instability (HP:0002172)1.61558568
89Hypotension (HP:0002615)1.58924680
90Hypercalciuria (HP:0002150)1.54791547
91Hypophosphatemic rickets (HP:0004912)1.54467854
92Panhypogammaglobulinemia (HP:0003139)1.53517846
93Polyuria (HP:0000103)1.53242647
94Adrenal overactivity (HP:0002717)1.52990264
95Abnormal tarsal ossification (HP:0008369)1.52457607
96Generalized hypotonia (HP:0001290)1.51939643
97Upper limb muscle weakness (HP:0003484)1.51641466
98Paresthesia (HP:0003401)1.50527055
99Flat face (HP:0012368)1.50325528
100Thyroiditis (HP:0100646)1.50226896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.69665498
2BLK4.99302668
3TNK23.94913096
4MAP3K143.74949497
5EIF2AK23.56315143
6RIPK43.34159952
7PRKCG2.47572113
8BMX2.39920976
9TNIK2.38187766
10NTRK32.16610068
11IRAK32.15901112
12JAK12.06553592
13PRPF4B2.01892852
14BUB11.88937578
15EPHA21.76900760
16IRAK11.62289567
17PRKD31.60173878
18CSF1R1.57190870
19ALK1.50061893
20PRKCH1.42491747
21TBK11.32049314
22CAMK11.28038489
23CAMK41.27291043
24FES1.26839022
25DAPK21.21221465
26PRKCE1.18081591
27IKBKE1.15205644
28SYK1.13042057
29STK111.08521198
30SIK21.05557551
31MKNK21.01687292
32ITK1.00595248
33AKT20.98364417
34CAMK2A0.97719490
35CAMK2G0.97102273
36CAMK1G0.96876673
37YES10.92743513
38PRKCQ0.85709866
39STK240.82577371
40PIK3CA0.79119921
41NTRK10.77895402
42EPHA40.75069319
43CAMK1D0.74913994
44PAK30.71525695
45PRKCD0.67483984
46HCK0.66851523
47CAMKK10.66139771
48RPS6KC10.64470440
49RPS6KL10.64470440
50LYN0.61306488
51PRKCZ0.61209654
52SGK20.61140558
53FGFR40.60525074
54KIT0.60072361
55WNK10.59976189
56ZAP700.58507377
57BMPR20.58405660
58TEC0.58404472
59RPS6KA60.57393514
60CSK0.57052354
61LCK0.56603431
62FYN0.56519415
63TRPM70.55695361
64INSR0.55694246
65MARK10.55132002
66GRK10.54017395
67TTN0.53524008
68SGK2230.52526653
69SGK4940.52526653
70IKBKB0.52488452
71PRKCB0.52305173
72FRK0.52251648
73MAPK30.50021556
74SGK10.48963409
75SRC0.48286048
76NTRK20.47989482
77EIF2AK30.47907980
78PRKACA0.45420304
79JAK20.44997440
80PRKCA0.44915586
81TXK0.44523848
82PDK10.43363050
83RET0.41871714
84TYK20.40534270
85MAP2K60.40478951
86CLK10.39632762
87FGR0.39281329
88PKN10.38995051
89PDGFRB0.38932086
90FLT30.36849459
91RPS6KB10.36428748
92MAP2K70.35161867
93MAPK70.33918992
94PKN20.33514666
95PRKG20.32878370
96PRKACG0.32399270
97MAP2K10.32186361
98CDK50.31851741
99MET0.30944436
100MINK10.30250801

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007604.44961771
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.96480152
3Histidine metabolism_Homo sapiens_hsa003402.87609603
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63837732
5beta-Alanine metabolism_Homo sapiens_hsa004102.61124030
6Arginine and proline metabolism_Homo sapiens_hsa003302.45146558
7Insulin secretion_Homo sapiens_hsa049112.36925616
8Hedgehog signaling pathway_Homo sapiens_hsa043402.34342729
9Tryptophan metabolism_Homo sapiens_hsa003802.17644379
10Basal cell carcinoma_Homo sapiens_hsa052172.13251911
11Arginine biosynthesis_Homo sapiens_hsa002202.10378671
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.07248870
13Fatty acid degradation_Homo sapiens_hsa000712.02642281
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.87406472
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.87214045
16Morphine addiction_Homo sapiens_hsa050321.83362963
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.81828681
18Dorso-ventral axis formation_Homo sapiens_hsa043201.77750344
19Fatty acid biosynthesis_Homo sapiens_hsa000611.77512957
20Calcium signaling pathway_Homo sapiens_hsa040201.40073462
21Propanoate metabolism_Homo sapiens_hsa006401.34335361
22Steroid biosynthesis_Homo sapiens_hsa001001.30417169
23ABC transporters_Homo sapiens_hsa020101.29460665
24TNF signaling pathway_Homo sapiens_hsa046681.29366072
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26318096
26Circadian entrainment_Homo sapiens_hsa047131.21225027
27Melanogenesis_Homo sapiens_hsa049161.12734388
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11111041
29Nicotine addiction_Homo sapiens_hsa050331.07166050
30cAMP signaling pathway_Homo sapiens_hsa040241.05196841
31Phagosome_Homo sapiens_hsa041451.03754607
32Staphylococcus aureus infection_Homo sapiens_hsa051501.01162789
33Graft-versus-host disease_Homo sapiens_hsa053321.00557396
34NF-kappa B signaling pathway_Homo sapiens_hsa040640.93309806
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93176693
36Retinol metabolism_Homo sapiens_hsa008300.92159479
37Hippo signaling pathway_Homo sapiens_hsa043900.87255570
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86988049
39Type I diabetes mellitus_Homo sapiens_hsa049400.84987828
40Ovarian steroidogenesis_Homo sapiens_hsa049130.84952227
41Cholinergic synapse_Homo sapiens_hsa047250.84680307
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82987319
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82203271
44Complement and coagulation cascades_Homo sapiens_hsa046100.81808469
45Glutamatergic synapse_Homo sapiens_hsa047240.79236288
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78572589
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77976384
48Inositol phosphate metabolism_Homo sapiens_hsa005620.77945783
49Osteoclast differentiation_Homo sapiens_hsa043800.77372959
50Long-term depression_Homo sapiens_hsa047300.76848020
51Primary immunodeficiency_Homo sapiens_hsa053400.76699848
52Hematopoietic cell lineage_Homo sapiens_hsa046400.73628044
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72925166
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72780895
55Nitrogen metabolism_Homo sapiens_hsa009100.72481714
56Fatty acid metabolism_Homo sapiens_hsa012120.71219495
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70590877
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.69722192
59Leishmaniasis_Homo sapiens_hsa051400.67034832
60Proteoglycans in cancer_Homo sapiens_hsa052050.66346164
61Small cell lung cancer_Homo sapiens_hsa052220.65665087
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65462307
63Pyruvate metabolism_Homo sapiens_hsa006200.64117635
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.63025773
65African trypanosomiasis_Homo sapiens_hsa051430.61489639
66Allograft rejection_Homo sapiens_hsa053300.58822032
67Butanoate metabolism_Homo sapiens_hsa006500.56483510
68Peroxisome_Homo sapiens_hsa041460.56356377
69Glycerolipid metabolism_Homo sapiens_hsa005610.53835152
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49761442
71GABAergic synapse_Homo sapiens_hsa047270.47639586
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47530346
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47468196
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46858069
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46268706
76Hepatitis C_Homo sapiens_hsa051600.45413292
77Lysine degradation_Homo sapiens_hsa003100.45349172
78Axon guidance_Homo sapiens_hsa043600.44753101
79Salivary secretion_Homo sapiens_hsa049700.42616544
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41676446
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40696135
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38631553
83Chemokine signaling pathway_Homo sapiens_hsa040620.37685993
84Bile secretion_Homo sapiens_hsa049760.36911600
85One carbon pool by folate_Homo sapiens_hsa006700.36558766
86Synaptic vesicle cycle_Homo sapiens_hsa047210.36363428
87Non-small cell lung cancer_Homo sapiens_hsa052230.36086092
88Measles_Homo sapiens_hsa051620.35220350
89Wnt signaling pathway_Homo sapiens_hsa043100.33693478
90Rheumatoid arthritis_Homo sapiens_hsa053230.33138451
91Ras signaling pathway_Homo sapiens_hsa040140.32892908
92B cell receptor signaling pathway_Homo sapiens_hsa046620.32416051
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32133817
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32032971
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31157016
96Amoebiasis_Homo sapiens_hsa051460.30310090
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29319415
98PPAR signaling pathway_Homo sapiens_hsa033200.28994350
99Linoleic acid metabolism_Homo sapiens_hsa005910.28207550
100Arachidonic acid metabolism_Homo sapiens_hsa005900.28148941

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