ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	9.38208012
2	positive regulation of cell cycle G2/M phase transition (GO:1902751)	9.38208012
3	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	9.23686297
4	glycine transport (GO:0015816)	8.94736193
5	positive regulation of DNA-templated transcription, initiation (GO:2000144)	8.12319198
6	response to water (GO:0009415)	7.94896583
7	positive regulation of fibroblast migration (GO:0010763)	7.88863141
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	7.54656538
9	hematopoietic stem cell proliferation (GO:0071425)	7.47384418
10	regulation of hair follicle development (GO:0051797)	7.40128265
11	detection of calcium ion (GO:0005513)	7.36075811
12	L-amino acid import (GO:0043092)	7.28088220
13	NAD biosynthetic process (GO:0009435)	7.23885319
14	inner ear receptor cell development (GO:0060119)	6.44662424
15	centriole assembly (GO:0098534)	6.42681492
16	superoxide anion generation (GO:0042554)	6.31028357
17	regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	5.99737683
18	nicotinamide nucleotide biosynthetic process (GO:0019359)	5.88476594
19	pyridine nucleotide biosynthetic process (GO:0019363)	5.88476594
20	reflex (GO:0060004)	5.79798107
21	exogenous drug catabolic process (GO:0042738)	5.78636513
22	skeletal muscle fiber development (GO:0048741)	5.75168619
23	amino acid import (GO:0043090)	5.59835333
24	regulation of nuclear cell cycle DNA replication (GO:0033262)	5.28469397
25	cellular response to vitamin D (GO:0071305)	5.18210210
26	response to hepatocyte growth factor (GO:0035728)	5.17555659
27	cellular response to hepatocyte growth factor stimulus (GO:0035729)	5.17555659
28	regulation of DNA-templated transcription, initiation (GO:2000142)	4.99673878
29	pyridine-containing compound biosynthetic process (GO:0072525)	4.89809431
30	response to lipoprotein particle (GO:0055094)	4.83035117
31	regulation of hair cycle (GO:0042634)	4.78023250
32	myoblast differentiation (GO:0045445)	4.77502547
33	myotube cell development (GO:0014904)	4.75127832
34	drug catabolic process (GO:0042737)	4.71408499
35	regulation of RIG-I signaling pathway (GO:0039535)	4.41044379
36	response to gravity (GO:0009629)	4.40079190
37	detection of mechanical stimulus involved in sensory perception (GO:0050974)	4.31102883
38	skeletal muscle contraction (GO:0003009)	4.27923599
39	chemosensory behavior (GO:0007635)	4.06562430
40	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	3.94957935
41	phosphorelay signal transduction system (GO:0000160)	3.81217627
42	neurotransmitter biosynthetic process (GO:0042136)	3.80968790
43	trabecula formation (GO:0060343)	3.80297959
44	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.70631070
45	cAMP catabolic process (GO:0006198)	3.64665048
46	NAD metabolic process (GO:0019674)	3.64026680
47	RNA-dependent DNA replication (GO:0006278)	3.59529945
48	cellular response to vitamin (GO:0071295)	3.57950393
49	sensory perception of taste (GO:0050909)	3.57390138
50	homocysteine metabolic process (GO:0050667)	3.55805895
51	positive regulation of osteoblast proliferation (GO:0033690)	3.52228635
52	diacylglycerol metabolic process (GO:0046339)	3.50094653
53	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.48938119
54	positive regulation of calcium ion import (GO:0090280)	3.44308205
55	telomere maintenance via telomerase (GO:0007004)	3.36282848
56	DNA integration (GO:0015074)	3.34199291
57	positive regulation of epidermis development (GO:0045684)	3.34198078
58	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.31668721
59	cyclic nucleotide catabolic process (GO:0009214)	3.25725010
60	negative regulation of myoblast differentiation (GO:0045662)	3.24813897
61	regulation of cell cycle G2/M phase transition (GO:1902749)	3.22611550
62	superoxide metabolic process (GO:0006801)	3.19776964
63	positive regulation of response to biotic stimulus (GO:0002833)	3.13591747
64	regulation of synapse maturation (GO:0090128)	3.09360997
65	detection of mechanical stimulus (GO:0050982)	3.08615409
66	negative regulation of protein localization to cell surface (GO:2000009)	3.01640637
67	multicellular organism reproduction (GO:0032504)	3.00664523
68	protein localization to microtubule (GO:0035372)	2.97938951
69	arginine catabolic process (GO:0006527)	2.96081028
70	eye photoreceptor cell differentiation (GO:0001754)	2.94562560
71	photoreceptor cell differentiation (GO:0046530)	2.94562560
72	activated T cell proliferation (GO:0050798)	2.92955985
73	regulation of fibroblast migration (GO:0010762)	2.90727216
74	chondrocyte differentiation (GO:0002062)	2.90626264
75	glomerulus development (GO:0032835)	2.88407234
76	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.88095344
77	tryptophan metabolic process (GO:0006568)	2.84382632
78	kynurenine metabolic process (GO:0070189)	2.84268714
79	positive regulation of bone mineralization (GO:0030501)	2.79041948
80	nephron tubule formation (GO:0072079)	2.75464461
81	cellular response to cAMP (GO:0071320)	2.75355939
82	lysine metabolic process (GO:0006553)	2.72694844
83	lysine catabolic process (GO:0006554)	2.72694844
84	indole-containing compound catabolic process (GO:0042436)	2.72519269
85	indolalkylamine catabolic process (GO:0046218)	2.72519269
86	tryptophan catabolic process (GO:0006569)	2.72519269
87	inositol phosphate-mediated signaling (GO:0048016)	2.71074561
88	meiotic chromosome segregation (GO:0045132)	2.69472754
89	negative regulation of neurotransmitter transport (GO:0051589)	2.64918368
90	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.63720162
91	ruffle organization (GO:0031529)	2.61754397
92	positive regulation of mitotic cell cycle phase transition (GO:1901992)	2.61186717
93	negative regulation of telomere maintenance (GO:0032205)	2.59339935
94	positive regulation of cell cycle phase transition (GO:1901989)	2.58934682
95	positive regulation of biomineral tissue development (GO:0070169)	2.57388295
96	detection of chemical stimulus (GO:0009593)	2.55833004
97	bone trabecula formation (GO:0060346)	12.0442059
98	response to parathyroid hormone (GO:0071107)	11.6227649
99	positive regulation of hair cycle (GO:0042635)	10.5774500
100	positive regulation of hair follicle development (GO:0051798)	10.5774500

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	8.08025751
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.55148160
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.27368601
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.87362815
5	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.59123874
6	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.37577056
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.22272188
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19403431
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.17605247
10	NFE2_27457419_Chip-Seq_LIVER_Mouse	2.07613169
11	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.01293261
12	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.98897040
13	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.93980125
14	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.85504673
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.74710307
16	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.73564101
17	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.73564101
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.72563479
19	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.72214074
20	DROSHA_22980978_ChIP-Seq_HELA_Human	1.71358472
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.70487349
22	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.70204727
23	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.66924075
24	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.66110538
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65840951
26	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.65805282
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.64414987
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62931469
29	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.61378322
30	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.61206778
31	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.58515805
32	P53_22387025_ChIP-Seq_ESCs_Mouse	1.58188551
33	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.57550640
34	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.57496918
35	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.52532304
36	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.51903230
37	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.51831685
38	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.50952284
39	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.50942926
40	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.47981993
41	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.45197595
42	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.44500260
43	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.43035076
44	PU1_27457419_Chip-Seq_LIVER_Mouse	1.42376451
45	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.41548447
46	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.41147304
47	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.41061787
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40772351
49	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.40303946
50	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.39707123
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.32865341
52	P300_18555785_Chip-Seq_ESCs_Mouse	1.32273768
53	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.31030080
54	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.30655273
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30185048
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28564839
57	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.27268035
58	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.27013141
59	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.26207321
60	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.25337581
61	KDM2B_26808549_Chip-Seq_REH_Human	1.24401487
62	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.23893974
63	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.22806731
64	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.22479209
65	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.21401017
66	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.21108539
67	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.17432097
68	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.17414262
69	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.17193380
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17159488
71	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.15742957
72	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.14860106
73	STAT3_23295773_ChIP-Seq_U87_Human	1.09683921
74	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06813685
75	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06158145
76	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06081771
77	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.03995924
78	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.03141912
79	GF1_26923725_Chip-Seq_HPCs_Mouse	1.00447873
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00403755
81	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.00313752
82	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99239606
83	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.98627873
84	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.95751030
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95439717
86	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.94716319
87	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94256885
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94114750
89	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.94051501
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.93854034
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93432477
92	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.93238277
93	TBL1_22424771_ChIP-Seq_293T_Human	0.92439378
94	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.91426318
95	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.91005923
96	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.90303228
97	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.90076746
98	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.89931069
99	TCF4_23295773_ChIP-Seq_U87_Human	0.89500224
100	AHR_22903824_ChIP-Seq_MCF-7_Human	0.86810253

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	8.49739961
2	MP0003195_calcinosis	8.10894393
3	MP0001188_hyperpigmentation	3.54595293
4	MP0000750_abnormal_muscle_regeneration	3.23587706
5	MP0009384_cardiac_valve_regurgitation	3.11748981
6	MP0005451_abnormal_body_composition	2.97642314
7	MP0004484_altered_response_of	2.80348959
8	MP0008057_abnormal_DNA_replication	2.59880374
9	MP0006072_abnormal_retinal_apoptosis	2.55600468
10	MP0004142_abnormal_muscle_tone	2.52068666
11	MP0004782_abnormal_surfactant_physiolog	2.48366758
12	MP0005410_abnormal_fertilization	2.48101827
13	MP0000678_abnormal_parathyroid_gland	2.45591080
14	MP0009764_decreased_sensitivity_to	2.30523963
15	MP0000579_abnormal_nail_morphology	2.28902829
16	MP0003283_abnormal_digestive_organ	2.28736501
17	MP0003646_muscle_fatigue	2.25698229
18	MP0005623_abnormal_meninges_morphology	2.20136309
19	MP0003941_abnormal_skin_development	2.19347863
20	MP0010386_abnormal_urinary_bladder	2.16455235
21	MP0004858_abnormal_nervous_system	2.11279459
22	MP0002168_other_aberrant_phenotype	1.99845088
23	MP0005645_abnormal_hypothalamus_physiol	1.91691107
24	MP0009785_altered_susceptibility_to	1.83872737
25	MP0004742_abnormal_vestibular_system	1.83280760
26	MP0002736_abnormal_nociception_after	1.79945184
27	MP0005167_abnormal_blood-brain_barrier	1.79648189
28	MP0001486_abnormal_startle_reflex	1.69018659
29	MP0009697_abnormal_copulation	1.66154869
30	MP0002876_abnormal_thyroid_physiology	1.65442187
31	MP0005165_increased_susceptibility_to	1.50015206
32	MP0003122_maternal_imprinting	1.47933736
33	MP0001501_abnormal_sleep_pattern	1.44939116
34	MP0004859_abnormal_synaptic_plasticity	1.33992105
35	MP0002108_abnormal_muscle_morphology	1.31062249
36	MP0004043_abnormal_pH_regulation	1.29657530
37	MP0000733_abnormal_muscle_development	1.29603656
38	MP0000383_abnormal_hair_follicle	1.27315660
39	MP0003123_paternal_imprinting	1.26059316
40	MP0010678_abnormal_skin_adnexa	1.18289535
41	MP0003045_fibrosis	1.12680989
42	MP0005085_abnormal_gallbladder_physiolo	1.11505084
43	MP0001968_abnormal_touch/_nociception	1.11480605
44	MP0000490_abnormal_crypts_of	1.06404877
45	MP0009745_abnormal_behavioral_response	1.02145555
46	MP0002896_abnormal_bone_mineralization	1.00372713
47	MP0003121_genomic_imprinting	0.97997392
48	MP0001502_abnormal_circadian_rhythm	0.97496232
49	MP0001440_abnormal_grooming_behavior	0.96969952
50	MP0002067_abnormal_sensory_capabilities	0.95537863
51	MP0008874_decreased_physiological_sensi	0.93355196
52	MP0003075_altered_response_to	0.92088065
53	MP0003635_abnormal_synaptic_transmissio	0.91695250
54	MP0004019_abnormal_vitamin_homeostasis	0.89832913
55	MP0005253_abnormal_eye_physiology	0.89450090
56	MP0005387_immune_system_phenotype	0.89109618
57	MP0001790_abnormal_immune_system	0.89109618
58	MP0003191_abnormal_cellular_cholesterol	0.88332569
59	MP0002139_abnormal_hepatobiliary_system	0.87662390
60	MP0002419_abnormal_innate_immunity	0.85253805
61	MP0005369_muscle_phenotype	0.84706494
62	MP0005395_other_phenotype	0.78061290
63	MP0002184_abnormal_innervation	0.70660232
64	MP0002396_abnormal_hematopoietic_system	0.70316654
65	MP0005360_urolithiasis	0.68804670
66	MP0002557_abnormal_social/conspecific_i	0.68319981
67	MP0005166_decreased_susceptibility_to	0.68134181
68	MP0008775_abnormal_heart_ventricle	0.66962562
69	MP0003566_abnormal_cell_adhesion	0.66303788
70	MP0001919_abnormal_reproductive_system	0.65866384
71	MP0002148_abnormal_hypersensitivity_rea	0.65066188
72	MP0008260_abnormal_autophagy	0.64129835
73	MP0002064_seizures	0.63545065
74	MP0010234_abnormal_vibrissa_follicle	0.60630816
75	MP0000427_abnormal_hair_cycle	0.58841221
76	MP0001958_emphysema	0.58328223
77	MP0000026_abnormal_inner_ear	0.58229136
78	MP0005083_abnormal_biliary_tract	0.58148569
79	MP0005551_abnormal_eye_electrophysiolog	0.56320039
80	MP0009046_muscle_twitch	0.55819337
81	MP0000767_abnormal_smooth_muscle	0.55677243
82	MP0001533_abnormal_skeleton_physiology	0.55261026
83	MP0005171_absent_coat_pigmentation	0.53611774
84	MP0005025_abnormal_response_to	0.53380875
85	MP0003436_decreased_susceptibility_to	0.51273620
86	MP0001845_abnormal_inflammatory_respons	0.50402002
87	MP0010155_abnormal_intestine_physiology	0.48830237
88	MP0001177_atelectasis	0.48575940
89	MP0000516_abnormal_urinary_system	0.47311796
90	MP0005367_renal/urinary_system_phenotyp	0.47311796
91	MP0001963_abnormal_hearing_physiology	0.47285043
92	MP0008872_abnormal_physiological_respon	0.47141175
93	MP0002723_abnormal_immune_serum	0.46967745
94	MP0002452_abnormal_antigen_presenting	0.45369590
95	MP0005647_abnormal_sex_gland	0.45347034
96	MP0005535_abnormal_body_temperature	0.45118935
97	MP0003011_delayed_dark_adaptation	0.45116459
98	MP0002063_abnormal_learning/memory/cond	0.44619046
99	MP0001800_abnormal_humoral_immune	0.44394239
100	MP0004133_heterotaxia	0.43950183

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	9.31107779
2	Oligodactyly (HP:0012165)	7.87999310
3	Absent hand (HP:0004050)	7.46898799
4	Pendular nystagmus (HP:0012043)	7.06614548
5	Abnormality of macular pigmentation (HP:0008002)	6.43249094
6	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	5.60198351
7	Increased circulating renin level (HP:0000848)	5.06738227
8	Severe Myopia (HP:0011003)	4.75175655
9	Agitation (HP:0000713)	4.66739362
10	Horizontal nystagmus (HP:0000666)	3.95058172
11	Alveolar cell carcinoma (HP:0006519)	3.91117040
12	Mesangial abnormality (HP:0001966)	3.91015306
13	Hypomagnesemia (HP:0002917)	3.77606587
14	Tetany (HP:0001281)	3.62937364
15	Striae distensae (HP:0001065)	3.60682700
16	Abdominal situs inversus (HP:0003363)	3.54279286
17	Abnormality of abdominal situs (HP:0011620)	3.54279286
18	Neoplasm of the tracheobronchial system (HP:0100552)	3.51726866
19	Hyperphosphatemia (HP:0002905)	3.41813798
20	Resting tremor (HP:0002322)	3.19734035
21	Muscle stiffness (HP:0003552)	3.16029451
22	Hypercortisolism (HP:0001578)	3.13511254
23	Retrobulbar optic neuritis (HP:0100654)	3.12905070
24	Optic neuritis (HP:0100653)	3.12905070
25	Abnormality of magnesium homeostasis (HP:0004921)	3.00484093
26	Mesomelia (HP:0003027)	2.93722530
27	Akinesia (HP:0002304)	2.76364634
28	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.75587731
29	Orchitis (HP:0100796)	2.75333471
30	Abnormal drinking behavior (HP:0030082)	2.69910690
31	Polydipsia (HP:0001959)	2.69910690
32	Depression (HP:0000716)	2.68069844
33	Metaphyseal irregularity (HP:0003025)	2.60775912
34	Absent toe (HP:0010760)	2.58151374
35	Macular degeneration (HP:0000608)	2.51806048
36	Abnormality of renin-angiotensin system (HP:0000847)	2.47464555
37	Restlessness (HP:0000711)	2.45579285
38	Generalized myoclonic seizures (HP:0002123)	2.43699599
39	Type 2 muscle fiber atrophy (HP:0003554)	2.35763576
40	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.33344595
41	Anxiety (HP:0000739)	2.29093531
42	Incomplete penetrance (HP:0003829)	2.27034057
43	Neonatal respiratory distress (HP:0002643)	2.26200869
44	Basal ganglia calcification (HP:0002135)	2.25821661
45	Erythroderma (HP:0001019)	2.25229527
46	Congenital ichthyosiform erythroderma (HP:0007431)	2.25190860
47	Myositis (HP:0100614)	2.22460642
48	Hypoplasia of the thymus (HP:0000778)	2.17495814
49	Distal lower limb amyotrophy (HP:0008944)	2.08031269
50	Abnormality of B cell number (HP:0010975)	2.04667797
51	B lymphocytopenia (HP:0010976)	2.04667797
52	Lack of skin elasticity (HP:0100679)	2.03996168
53	Muscle fiber atrophy (HP:0100295)	2.01803846
54	Split foot (HP:0001839)	11.5242086
55	Oligodactyly (hands) (HP:0001180)	11.2671677
56	Hypophosphatemia (HP:0002148)	1.99648413
57	Reduced antithrombin III activity (HP:0001976)	1.98279131
58	Tachypnea (HP:0002789)	1.97842471
59	Split hand (HP:0001171)	1.97119539
60	Distal lower limb muscle weakness (HP:0009053)	1.93155223
61	Lower limb amyotrophy (HP:0007210)	1.92628602
62	Hyperparathyroidism (HP:0000843)	1.92318739
63	Generalized tonic-clonic seizures (HP:0002069)	1.90502656
64	Neurodegeneration (HP:0002180)	1.89459725
65	Keratoconjunctivitis sicca (HP:0001097)	1.88465946
66	Fatigable weakness (HP:0003473)	1.83970927
67	Abnormality of the neuromuscular junction (HP:0003398)	1.83970927
68	Focal segmental glomerulosclerosis (HP:0000097)	1.82188639
69	Recurrent gram-negative bacterial infections (HP:0005420)	1.80918295
70	Poor suck (HP:0002033)	1.80852992
71	Intellectual disability, moderate (HP:0002342)	1.78551000
72	Abnormal urine phosphate concentration (HP:0012599)	1.77331067
73	Status epilepticus (HP:0002133)	1.76322324
74	Truncal obesity (HP:0001956)	1.75866650
75	Gangrene (HP:0100758)	1.74755167
76	Abnormal connection of the cardiac segments (HP:0011545)	1.73964094
77	Abnormal ventriculo-arterial connection (HP:0011563)	1.73964094
78	Transposition of the great arteries (HP:0001669)	1.73964094
79	Steatorrhea (HP:0002570)	1.73506165
80	Pancreatitis (HP:0001733)	1.73386650
81	Respiratory distress (HP:0002098)	1.72305469
82	Abnormality of the intrinsic pathway (HP:0010989)	1.72022550
83	Childhood onset (HP:0011463)	1.68232007
84	Eosinophilia (HP:0001880)	1.68022889
85	Keratoconjunctivitis (HP:0001096)	1.64467379
86	Facial cleft (HP:0002006)	1.63027725
87	Conical tooth (HP:0000698)	1.62700685
88	Postural instability (HP:0002172)	1.61558568
89	Hypotension (HP:0002615)	1.58924680
90	Hypercalciuria (HP:0002150)	1.54791547
91	Hypophosphatemic rickets (HP:0004912)	1.54467854
92	Panhypogammaglobulinemia (HP:0003139)	1.53517846
93	Polyuria (HP:0000103)	1.53242647
94	Adrenal overactivity (HP:0002717)	1.52990264
95	Abnormal tarsal ossification (HP:0008369)	1.52457607
96	Generalized hypotonia (HP:0001290)	1.51939643
97	Upper limb muscle weakness (HP:0003484)	1.51641466
98	Paresthesia (HP:0003401)	1.50527055
99	Flat face (HP:0012368)	1.50325528
100	Thyroiditis (HP:0100646)	1.50226896

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.69665498
2	BLK	4.99302668
3	TNK2	3.94913096
4	MAP3K14	3.74949497
5	EIF2AK2	3.56315143
6	RIPK4	3.34159952
7	PRKCG	2.47572113
8	BMX	2.39920976
9	TNIK	2.38187766
10	NTRK3	2.16610068
11	IRAK3	2.15901112
12	JAK1	2.06553592
13	PRPF4B	2.01892852
14	BUB1	1.88937578
15	EPHA2	1.76900760
16	IRAK1	1.62289567
17	PRKD3	1.60173878
18	CSF1R	1.57190870
19	ALK	1.50061893
20	PRKCH	1.42491747
21	TBK1	1.32049314
22	CAMK1	1.28038489
23	CAMK4	1.27291043
24	FES	1.26839022
25	DAPK2	1.21221465
26	PRKCE	1.18081591
27	IKBKE	1.15205644
28	SYK	1.13042057
29	STK11	1.08521198
30	SIK2	1.05557551
31	MKNK2	1.01687292
32	ITK	1.00595248
33	AKT2	0.98364417
34	CAMK2A	0.97719490
35	CAMK2G	0.97102273
36	CAMK1G	0.96876673
37	YES1	0.92743513
38	PRKCQ	0.85709866
39	STK24	0.82577371
40	PIK3CA	0.79119921
41	NTRK1	0.77895402
42	EPHA4	0.75069319
43	CAMK1D	0.74913994
44	PAK3	0.71525695
45	PRKCD	0.67483984
46	HCK	0.66851523
47	CAMKK1	0.66139771
48	RPS6KL1	0.64470440
49	RPS6KC1	0.64470440
50	LYN	0.61306488
51	PRKCZ	0.61209654
52	SGK2	0.61140558
53	FGFR4	0.60525074
54	KIT	0.60072361
55	WNK1	0.59976189
56	ZAP70	0.58507377
57	BMPR2	0.58405660
58	TEC	0.58404472
59	RPS6KA6	0.57393514
60	CSK	0.57052354
61	LCK	0.56603431
62	FYN	0.56519415
63	TRPM7	0.55695361
64	INSR	0.55694246
65	MARK1	0.55132002
66	GRK1	0.54017395
67	TTN	0.53524008
68	SGK223	0.52526653
69	SGK494	0.52526653
70	IKBKB	0.52488452
71	PRKCB	0.52305173
72	FRK	0.52251648
73	MAPK3	0.50021556
74	SGK1	0.48963409
75	SRC	0.48286048
76	NTRK2	0.47989482
77	EIF2AK3	0.47907980
78	PRKACA	0.45420304
79	JAK2	0.44997440
80	PRKCA	0.44915586
81	TXK	0.44523848
82	PDK1	0.43363050
83	RET	0.41871714
84	TYK2	0.40534270
85	MAP2K6	0.40478951
86	CLK1	0.39632762
87	FGR	0.39281329
88	PKN1	0.38995051
89	PDGFRB	0.38932086
90	FLT3	0.36849459
91	RPS6KB1	0.36428748
92	MAP2K7	0.35161867
93	MAPK7	0.33918992
94	PKN2	0.33514666
95	PRKG2	0.32878370
96	PRKACG	0.32399270
97	MAP2K1	0.32186361
98	CDK5	0.31851741
99	MET	0.30944436
100	MINK1	0.30250801

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	4.44961771
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.96480152
3	Histidine metabolism_Homo sapiens_hsa00340	2.87609603
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.63837732
5	beta-Alanine metabolism_Homo sapiens_hsa00410	2.61124030
6	Arginine and proline metabolism_Homo sapiens_hsa00330	2.45146558
7	Insulin secretion_Homo sapiens_hsa04911	2.36925616
8	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.34342729
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.17644379
10	Basal cell carcinoma_Homo sapiens_hsa05217	2.13251911
11	Arginine biosynthesis_Homo sapiens_hsa00220	2.10378671
12	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.07248870
13	Fatty acid degradation_Homo sapiens_hsa00071	2.02642281
14	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.87406472
15	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.87214045
16	Morphine addiction_Homo sapiens_hsa05032	1.83362963
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.81828681
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.77750344
19	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.77512957
20	Calcium signaling pathway_Homo sapiens_hsa04020	1.40073462
21	Propanoate metabolism_Homo sapiens_hsa00640	1.34335361
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.30417169
23	ABC transporters_Homo sapiens_hsa02010	1.29460665
24	TNF signaling pathway_Homo sapiens_hsa04668	1.29366072
25	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.26318096
26	Circadian entrainment_Homo sapiens_hsa04713	1.21225027
27	Melanogenesis_Homo sapiens_hsa04916	1.12734388
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11111041
29	Nicotine addiction_Homo sapiens_hsa05033	1.07166050
30	cAMP signaling pathway_Homo sapiens_hsa04024	1.05196841
31	Phagosome_Homo sapiens_hsa04145	1.03754607
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.01162789
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.00557396
34	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.93309806
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93176693
36	Retinol metabolism_Homo sapiens_hsa00830	0.92159479
37	Hippo signaling pathway_Homo sapiens_hsa04390	0.87255570
38	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.86988049
39	Type I diabetes mellitus_Homo sapiens_hsa04940	0.84987828
40	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84952227
41	Cholinergic synapse_Homo sapiens_hsa04725	0.84680307
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82987319
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.82203271
44	Complement and coagulation cascades_Homo sapiens_hsa04610	0.81808469
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.79236288
46	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.78572589
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77976384
48	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.77945783
49	Osteoclast differentiation_Homo sapiens_hsa04380	0.77372959
50	Long-term depression_Homo sapiens_hsa04730	0.76848020
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.76699848
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.73628044
53	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.72925166
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72780895
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.72481714
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.71219495
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70590877
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69722192
59	Leishmaniasis_Homo sapiens_hsa05140	0.67034832
60	Proteoglycans in cancer_Homo sapiens_hsa05205	0.66346164
61	Small cell lung cancer_Homo sapiens_hsa05222	0.65665087
62	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.65462307
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.64117635
64	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.63025773
65	African trypanosomiasis_Homo sapiens_hsa05143	0.61489639
66	Allograft rejection_Homo sapiens_hsa05330	0.58822032
67	Butanoate metabolism_Homo sapiens_hsa00650	0.56483510
68	Peroxisome_Homo sapiens_hsa04146	0.56356377
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53835152
70	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49761442
71	GABAergic synapse_Homo sapiens_hsa04727	0.47639586
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47530346
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.47468196
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.46858069
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46268706
76	Hepatitis C_Homo sapiens_hsa05160	0.45413292
77	Lysine degradation_Homo sapiens_hsa00310	0.45349172
78	Axon guidance_Homo sapiens_hsa04360	0.44753101
79	Salivary secretion_Homo sapiens_hsa04970	0.42616544
80	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41676446
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40696135
82	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38631553
83	Chemokine signaling pathway_Homo sapiens_hsa04062	0.37685993
84	Bile secretion_Homo sapiens_hsa04976	0.36911600
85	One carbon pool by folate_Homo sapiens_hsa00670	0.36558766
86	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36363428
87	Non-small cell lung cancer_Homo sapiens_hsa05223	0.36086092
88	Measles_Homo sapiens_hsa05162	0.35220350
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.33693478
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33138451
91	Ras signaling pathway_Homo sapiens_hsa04014	0.32892908
92	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.32416051
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.32133817
94	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.32032971
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.31157016
96	Amoebiasis_Homo sapiens_hsa05146	0.30310090
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.29319415
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.28994350
99	Linoleic acid metabolism_Homo sapiens_hsa00591	0.28207550
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.28148941

TRAJ59

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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