TRAK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.81179539
2cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.58200293
3negative regulation of potassium ion transmembrane transport (GO:1901380)4.56798725
4sarcomere organization (GO:0045214)4.42459642
5plasma membrane repair (GO:0001778)4.35103580
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.35047992
7cardiac myofibril assembly (GO:0055003)4.30537882
8carnitine shuttle (GO:0006853)4.19739476
9skeletal muscle contraction (GO:0003009)4.19317544
10cell communication involved in cardiac conduction (GO:0086065)4.17270195
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.17088202
12cell communication by electrical coupling (GO:0010644)4.09906809
13regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.98291497
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.93808083
15ventricular cardiac muscle cell action potential (GO:0086005)3.93504288
16axonemal dynein complex assembly (GO:0070286)3.91400617
17cardiac muscle contraction (GO:0060048)3.89631206
18regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.86546047
19actin filament-based movement (GO:0030048)3.83692372
20fatty acid transmembrane transport (GO:1902001)3.80332163
21myofibril assembly (GO:0030239)3.79964081
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.55071123
23sodium ion export (GO:0071436)3.54403032
24regulation of membrane repolarization (GO:0060306)3.52357036
25tricarboxylic acid cycle (GO:0006099)3.50620349
26cilium or flagellum-dependent cell motility (GO:0001539)3.42106057
27bundle of His cell to Purkinje myocyte communication (GO:0086069)3.31021721
28response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.30175207
29regulation of actin filament-based movement (GO:1903115)3.28756348
30response to inactivity (GO:0014854)3.26523755
31muscle filament sliding (GO:0030049)3.17989860
32actin-myosin filament sliding (GO:0033275)3.17989860
33carnitine transmembrane transport (GO:1902603)3.14629525
34positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.14588503
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14149849
36actomyosin structure organization (GO:0031032)3.12231019
37potassium ion import (GO:0010107)3.12143802
38striated muscle contraction (GO:0006941)3.11826412
39regulation of skeletal muscle contraction (GO:0014819)3.08924350
40sarcoplasmic reticulum calcium ion transport (GO:0070296)3.08690226
412-oxoglutarate metabolic process (GO:0006103)3.08660279
42cardiac muscle hypertrophy (GO:0003300)3.05947166
43cardiac conduction (GO:0061337)3.05628143
44regulation of synapse structural plasticity (GO:0051823)3.02986123
45membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.02179916
46locomotory exploration behavior (GO:0035641)2.98650262
47motile cilium assembly (GO:0044458)2.98177898
48carnitine transport (GO:0015879)2.95347304
49amino-acid betaine transport (GO:0015838)2.95347304
50striated muscle hypertrophy (GO:0014897)2.95057879
51activation of protein kinase A activity (GO:0034199)2.95040470
52regulation of fatty acid oxidation (GO:0046320)2.94658278
53regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.94519363
54regulation of heart rate by cardiac conduction (GO:0086091)2.91157866
55relaxation of cardiac muscle (GO:0055119)2.91121672
56lysine metabolic process (GO:0006553)2.90330236
57lysine catabolic process (GO:0006554)2.90330236
58cardiac muscle cell development (GO:0055013)2.90286117
59regulation of cell communication by electrical coupling (GO:0010649)2.90261878
60cardiac muscle cell action potential involved in contraction (GO:0086002)2.89984195
61creatine metabolic process (GO:0006600)2.89852261
62regulation of the force of heart contraction (GO:0002026)2.89254737
63cardiac muscle cell action potential (GO:0086001)2.87605980
64regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.86739261
65cellular potassium ion homeostasis (GO:0030007)2.86695887
66regulation of calcium ion transmembrane transporter activity (GO:1901019)2.86181784
67regulation of calcium ion transmembrane transport (GO:1903169)2.86181784
68striated muscle adaptation (GO:0014888)2.85427586
69cilium movement (GO:0003341)2.84949099
70negative regulation of potassium ion transport (GO:0043267)2.76841940
71muscle contraction (GO:0006936)2.76599819
72heart trabecula formation (GO:0060347)2.76239422
73synaptic vesicle maturation (GO:0016188)2.75862337
74positive regulation of potassium ion transmembrane transport (GO:1901381)2.75638170
75response to muscle activity (GO:0014850)2.74833510
76cardiac cell development (GO:0055006)2.74569866
77NADH metabolic process (GO:0006734)2.72906960
78regulation of striated muscle contraction (GO:0006942)2.72346174
79membrane repolarization (GO:0086009)2.72108138
80regulation of short-term neuronal synaptic plasticity (GO:0048172)2.71188568
81neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.71044359
82vocalization behavior (GO:0071625)2.70316017
83membrane repolarization during action potential (GO:0086011)2.70313424
84regulation of acyl-CoA biosynthetic process (GO:0050812)2.68921392
85adult heart development (GO:0007512)2.68300262
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67779747
87positive regulation of cation channel activity (GO:2001259)2.66813572
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65287021
89actin-mediated cell contraction (GO:0070252)2.64157107
90negative regulation of cell size (GO:0045792)2.62737206
91dicarboxylic acid biosynthetic process (GO:0043650)2.62036004
92regulation of NFAT protein import into nucleus (GO:0051532)2.61510455
93cardiac muscle adaptation (GO:0014887)2.60768719
94cardiac muscle hypertrophy in response to stress (GO:0014898)2.60768719
95muscle hypertrophy in response to stress (GO:0003299)2.60768719
96regulation of sequestering of triglyceride (GO:0010889)2.60015176
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.59464672
98positive regulation of sodium ion transport (GO:0010765)2.59218045
99regulation of relaxation of muscle (GO:1901077)2.59131237
100positive regulation of fatty acid beta-oxidation (GO:0032000)2.58417246
101regulation of cardiac muscle cell contraction (GO:0086004)2.57967482
102aspartate family amino acid catabolic process (GO:0009068)2.56873377
103positive regulation of fatty acid oxidation (GO:0046321)2.56783325
104positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56440914
105regulation of fatty acid beta-oxidation (GO:0031998)2.53325567
106cellular sodium ion homeostasis (GO:0006883)2.53023705
107layer formation in cerebral cortex (GO:0021819)2.51645255
108skeletal muscle adaptation (GO:0043501)2.51548589
109muscle hypertrophy (GO:0014896)2.51348459
110regulation of ARF protein signal transduction (GO:0032012)2.51254743
111regulation of heart rate (GO:0002027)2.50849633
112muscle system process (GO:0003012)2.49483623
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.48648305
114regulation of p38MAPK cascade (GO:1900744)2.47197940
115regulation of coenzyme metabolic process (GO:0051196)2.44561088
116regulation of cofactor metabolic process (GO:0051193)2.44561088
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.43811603
118regulation of heart contraction (GO:0008016)2.43402388
119camera-type eye morphogenesis (GO:0048593)2.42752495
120negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.41676655
121cardiac muscle tissue morphogenesis (GO:0055008)2.40654006
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40052074
123skeletal muscle fiber development (GO:0048741)2.38943384
124cellular response to catecholamine stimulus (GO:0071870)2.38771580
125cellular response to monoamine stimulus (GO:0071868)2.38771580
126cell-cell junction maintenance (GO:0045217)2.38416193
127cell junction maintenance (GO:0034331)2.33179087
128myoblast fusion (GO:0007520)2.29829253
129cerebellar granule cell differentiation (GO:0021707)2.29669571
130muscle tissue morphogenesis (GO:0060415)2.28615619
131nucleus localization (GO:0051647)2.28167876
132myotube differentiation (GO:0014902)2.26696079
133establishment of nucleus localization (GO:0040023)2.23900493
134cellular response to epinephrine stimulus (GO:0071872)2.22651164
135negative regulation of inclusion body assembly (GO:0090084)2.19882164
136response to monoamine (GO:0071867)2.19521742
137response to catecholamine (GO:0071869)2.19521742
138left/right pattern formation (GO:0060972)2.18447782
139muscle adaptation (GO:0043500)2.16182022
140embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15788418
141positive regulation of myotube differentiation (GO:0010831)2.12444706
142epithelial cell-cell adhesion (GO:0090136)2.12388056
143negative regulation of protein localization to cell surface (GO:2000009)2.11766844
144ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.11267294
145glycogen catabolic process (GO:0005980)2.11210855
146skeletal muscle tissue development (GO:0007519)2.10921034
147syncytium formation by plasma membrane fusion (GO:0000768)2.10247906
148macroautophagy (GO:0016236)2.10030924
149cell-substrate adherens junction assembly (GO:0007045)2.09210070
150focal adhesion assembly (GO:0048041)2.09210070
151interkinetic nuclear migration (GO:0022027)2.09053001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.07661331
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04916773
3DROSHA_22980978_ChIP-Seq_HELA_Human2.34009144
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.23646287
5ESR1_20079471_ChIP-ChIP_T-47D_Human1.99919449
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98028597
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97259830
8EP300_21415370_ChIP-Seq_HL-1_Mouse1.90570212
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86458644
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.83630386
11RARB_27405468_Chip-Seq_BRAIN_Mouse1.83126133
12TP63_17297297_ChIP-ChIP_HaCaT_Human1.82385259
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77827946
14TBX20_22080862_ChIP-Seq_HEART_Mouse1.73926018
15TBX20_22328084_ChIP-Seq_HEART_Mouse1.73926018
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73459302
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.73036814
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72915263
19LXR_22158963_ChIP-Seq_LIVER_Mouse1.70712254
20* ESR2_21235772_ChIP-Seq_MCF-7_Human1.68557730
21KDM2B_26808549_Chip-Seq_K562_Human1.66232215
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63340986
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62749343
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62749343
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60169984
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56679616
27* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55764242
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52588364
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52478506
30NFIB_24661679_ChIP-Seq_LUNG_Mouse1.51830689
31KDM2B_26808549_Chip-Seq_DND41_Human1.44021389
32LXR_22292898_ChIP-Seq_THP-1_Human1.42141877
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41458673
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41406945
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40452593
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40338912
37* ZNF263_19887448_ChIP-Seq_K562_Human1.39436007
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39022961
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37745021
40* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37621117
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.35074108
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33428997
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33365098
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32745608
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31775514
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30782102
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30273057
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29557550
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27873932
50* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27746699
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26824799
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25983039
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25245029
54* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24631259
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22535568
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21832255
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20282243
58* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20172011
59REST_21632747_ChIP-Seq_MESCs_Mouse1.20061249
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.19870094
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.17843553
62* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15794238
63AHR_22903824_ChIP-Seq_MCF-7_Human1.15062743
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15028763
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13864649
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.13180877
67CTCF_27219007_Chip-Seq_Bcells_Human1.12736131
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12230841
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10961467
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10018634
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.10008632
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.09418187
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09253071
74* CLOCK_20551151_ChIP-Seq_293T_Human1.08977332
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07794519
76CREB1_26743006_Chip-Seq_LNCaP_Human1.07558520
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06288911
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05812975
79RACK7_27058665_Chip-Seq_MCF-7_Human1.05193379
80AR_21572438_ChIP-Seq_LNCaP_Human1.04978356
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.04763153
82* RUNX1_27514584_Chip-Seq_MCF-7_Human1.03934421
83AR_19668381_ChIP-Seq_PC3_Human1.01108639
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00931177
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00300315
86* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99803680
87SOX2_21211035_ChIP-Seq_LN229_Gbm0.99667056
88* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99640237
89* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99225199
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99055103
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98037500
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.97837615
93P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97354487
94GATA1_19941826_ChIP-Seq_K562_Human0.95608793
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94781506
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94692736
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.94267803
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94201437
99RING1B_27294783_Chip-Seq_NPCs_Mouse0.94000405
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93863186
101TCF7_22412390_ChIP-Seq_EML_Mouse0.93831334
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.93508604
103RING1B_27294783_Chip-Seq_ESCs_Mouse0.93434647
104SMC4_20622854_ChIP-Seq_HELA_Human0.91857795
105* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90985720
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90025420
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.90017275
108* MYC_27129775_Chip-Seq_CORNEA_Mouse0.88817569
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88759915
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.88474911
111* TP63_22573176_ChIP-Seq_HFKS_Human0.87921191
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87243806
113* FOXO3_23340844_ChIP-Seq_DLD1_Human0.86547688
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85920501
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85887073
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84764030
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.84606653
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84444931
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84440263
120TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84196951
121* TP53_23651856_ChIP-Seq_MEFs_Mouse0.84016715
122* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.80990474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.19731163
2MP0000751_myopathy4.24729339
3MP0003646_muscle_fatigue4.21377891
4MP0004084_abnormal_cardiac_muscle3.66094412
5MP0004215_abnormal_myocardial_fiber3.36457312
6MP0004859_abnormal_synaptic_plasticity3.05631346
7MP0004036_abnormal_muscle_relaxation3.01936261
8MP0004130_abnormal_muscle_cell2.98713716
9MP0005409_darkened_coat_color2.78383069
10MP0005330_cardiomyopathy2.67230446
11MP0000749_muscle_degeneration2.53849777
12MP0004087_abnormal_muscle_fiber2.45376514
13MP0002972_abnormal_cardiac_muscle2.18738044
14MP0005620_abnormal_muscle_contractility2.10280646
15MP0003137_abnormal_impulse_conducting2.02142022
16MP0004145_abnormal_muscle_electrophysio1.97599622
17MP0009780_abnormal_chondrocyte_physiolo1.94954774
18MP0004484_altered_response_of1.94656505
19MP0008775_abnormal_heart_ventricle1.93881455
20MP0002269_muscular_atrophy1.91954102
21MP0002909_abnormal_adrenal_gland1.91526847
22MP0005670_abnormal_white_adipose1.90503430
23MP0000733_abnormal_muscle_development1.86922525
24MP0003705_abnormal_hypodermis_morpholog1.85536884
25MP0010630_abnormal_cardiac_muscle1.85515857
26MP0008961_abnormal_basal_metabolism1.83980579
27MP0005666_abnormal_adipose_tissue1.83965825
28MP0000747_muscle_weakness1.81636517
29MP0002822_catalepsy1.79015350
30MP0000750_abnormal_muscle_regeneration1.77462956
31MP0006138_congestive_heart_failure1.77051183
32MP0001544_abnormal_cardiovascular_syste1.76218830
33MP0005385_cardiovascular_system_phenoty1.76218830
34MP0004085_abnormal_heartbeat1.72756352
35* MP0002106_abnormal_muscle_physiology1.71898542
36MP0005451_abnormal_body_composition1.67949344
37MP0005360_urolithiasis1.66283894
38MP0004233_abnormal_muscle_weight1.63074448
39MP0004270_analgesia1.61325554
40MP0000759_abnormal_skeletal_muscle1.56243113
41MP0004510_myositis1.55393360
42MP0003635_abnormal_synaptic_transmissio1.53836291
43MP0004185_abnormal_adipocyte_glucose1.49794507
44MP0005085_abnormal_gallbladder_physiolo1.44385809
45MP0009384_cardiac_valve_regurgitation1.43721409
46MP0005423_abnormal_somatic_nervous1.43196936
47MP0004858_abnormal_nervous_system1.42325444
48MP0005375_adipose_tissue_phenotype1.41034236
49MP0002139_abnormal_hepatobiliary_system1.40563755
50MP0000566_synostosis1.37488616
51* MP0005369_muscle_phenotype1.37482075
52MP0003252_abnormal_bile_duct1.24174029
53MP0003091_abnormal_cell_migration1.21531945
54MP0010234_abnormal_vibrissa_follicle1.21008660
55MP0010329_abnormal_lipoprotein_level1.20293900
56MP0005503_abnormal_tendon_morphology1.19841275
57MP0005365_abnormal_bile_salt1.19754563
58MP0003045_fibrosis1.16014137
59MP0003329_amyloid_beta_deposits1.15476103
60MP0002234_abnormal_pharynx_morphology1.14232128
61MP0002063_abnormal_learning/memory/cond1.12592604
62MP0005167_abnormal_blood-brain_barrier1.12583314
63MP0001958_emphysema1.12335561
64MP0003123_paternal_imprinting1.11855293
65MP0001299_abnormal_eye_distance/1.11019252
66MP0002896_abnormal_bone_mineralization1.10797392
67MP0003279_aneurysm1.08315643
68MP0008569_lethality_at_weaning1.07289897
69MP0003828_pulmonary_edema1.07006974
70MP0000003_abnormal_adipose_tissue1.04338796
71MP0002249_abnormal_larynx_morphology1.04105983
72MP0000534_abnormal_ureter_morphology1.01186306
73MP0003221_abnormal_cardiomyocyte_apopto0.99973552
74MP0009745_abnormal_behavioral_response0.99010750
75MP0001984_abnormal_olfaction0.98239849
76MP0002971_abnormal_brown_adipose0.98066928
77MP0005535_abnormal_body_temperature0.97792078
78MP0003122_maternal_imprinting0.97265627
79MP0002118_abnormal_lipid_homeostasis0.96982385
80MP0000013_abnormal_adipose_tissue0.96915885
81MP0005257_abnormal_intraocular_pressure0.96209333
82MP0005275_abnormal_skin_tensile0.92904298
83MP0003879_abnormal_hair_cell0.91484408
84MP0009046_muscle_twitch0.91158282
85MP0002064_seizures0.90206278
86MP0004043_abnormal_pH_regulation0.89338536
87MP0002078_abnormal_glucose_homeostasis0.89192572
88MP0005187_abnormal_penis_morphology0.85891719
89MP0003950_abnormal_plasma_membrane0.84905686
90MP0002332_abnormal_exercise_endurance0.84821022
91MP0000762_abnormal_tongue_morphology0.84636251
92MP0009840_abnormal_foam_cell0.83569292
93MP0003300_gastrointestinal_ulcer0.83527443
94MP0002127_abnormal_cardiovascular_syste0.83398351
95MP0001501_abnormal_sleep_pattern0.81734751
96MP0001440_abnormal_grooming_behavior0.81598523
97MP0008874_decreased_physiological_sensi0.80584151
98MP0006036_abnormal_mitochondrial_physio0.79427427
99MP0002653_abnormal_ependyma_morphology0.79227401
100MP0010368_abnormal_lymphatic_system0.78688834
101MP0000266_abnormal_heart_morphology0.78328792
102MP0002572_abnormal_emotion/affect_behav0.77166567
103MP0000230_abnormal_systemic_arterial0.76449335
104MP0008875_abnormal_xenobiotic_pharmacok0.76203808
105MP0004924_abnormal_behavior0.75901554
106MP0005386_behavior/neurological_phenoty0.75901554
107MP0003633_abnormal_nervous_system0.74853084
108MP0000778_abnormal_nervous_system0.74664592
109MP0005623_abnormal_meninges_morphology0.74587919
110MP0000767_abnormal_smooth_muscle0.73826185
111MP0001502_abnormal_circadian_rhythm0.71582555
112MP0001849_ear_inflammation0.71416618
113MP0003566_abnormal_cell_adhesion0.71385747
114MP0003075_altered_response_to0.71118238
115MP0000569_abnormal_digit_pigmentation0.70853443
116MP0001666_abnormal_nutrient_absorption0.69564507
117MP0003634_abnormal_glial_cell0.69534499
118MP0005165_increased_susceptibility_to0.69259280
119MP0002108_abnormal_muscle_morphology0.68915478
120MP0001486_abnormal_startle_reflex0.68723136
121MP0002272_abnormal_nervous_system0.68132041
122MP0005083_abnormal_biliary_tract0.67669741
123MP0005334_abnormal_fat_pad0.67226493
124MP0008438_abnormal_cutaneous_collagen0.66326547
125MP0005448_abnormal_energy_balance0.65443427
126MP0004134_abnormal_chest_morphology0.64761643
127MP0005319_abnormal_enzyme/_coenzyme0.64451798
128MP0002128_abnormal_blood_circulation0.63782241
129MP0003283_abnormal_digestive_organ0.62975834
130MP0000955_abnormal_spinal_cord0.62698673
131MP0002734_abnormal_mechanical_nocicepti0.61708163
132MP0005584_abnormal_enzyme/coenzyme_acti0.61593544
133MP0001879_abnormal_lymphatic_vessel0.58226898
134MP0000678_abnormal_parathyroid_gland0.57745701
135MP0002168_other_aberrant_phenotype0.56500718
136MP0005076_abnormal_cell_differentiation0.56272613
137MP0009115_abnormal_fat_cell0.53790080

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.95037432
2Nemaline bodies (HP:0003798)5.60461217
3Exercise-induced myalgia (HP:0003738)5.03308924
4Bundle branch block (HP:0011710)4.52173823
5Ventricular tachycardia (HP:0004756)4.51424925
6Right ventricular cardiomyopathy (HP:0011663)4.34228817
7Exercise-induced muscle cramps (HP:0003710)4.29048943
8Hyporeflexia of lower limbs (HP:0002600)4.27170338
9Calf muscle hypertrophy (HP:0008981)4.20216640
10Atrial fibrillation (HP:0005110)4.11661039
11Syncope (HP:0001279)4.02701883
12Myoglobinuria (HP:0002913)3.95922851
13Primary atrial arrhythmia (HP:0001692)3.91289397
14Ventricular fibrillation (HP:0001663)3.91188931
15Muscle fiber splitting (HP:0003555)3.88038356
16Muscle hypertrophy of the lower extremities (HP:0008968)3.83853740
17Difficulty running (HP:0009046)3.72827072
18Supraventricular tachycardia (HP:0004755)3.68717413
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.67456534
20Abnormality of the calf musculature (HP:0001430)3.64286631
21Supraventricular arrhythmia (HP:0005115)3.63708895
22Prolonged QT interval (HP:0001657)3.62484833
23Distal arthrogryposis (HP:0005684)3.57710311
24Centrally nucleated skeletal muscle fibers (HP:0003687)3.51478225
25Ventricular arrhythmia (HP:0004308)3.42966012
26Subaortic stenosis (HP:0001682)3.42560454
27Abnormality of the left ventricular outflow tract (HP:0011103)3.42560454
28Ulnar deviation of the wrist (HP:0003049)3.41139694
29Heart block (HP:0012722)3.37799008
30Myopathic facies (HP:0002058)3.37641132
31Round ear (HP:0100830)3.34750853
32Increased connective tissue (HP:0009025)3.33995853
33Dysmetric saccades (HP:0000641)3.32789388
34Abnormal ciliary motility (HP:0012262)3.30327323
35Asymmetric septal hypertrophy (HP:0001670)3.29193259
36Abnormal respiratory motile cilium physiology (HP:0012261)3.25539703
37Atrioventricular block (HP:0001678)3.24296303
38Abnormal respiratory epithelium morphology (HP:0012253)3.20961243
39Abnormal respiratory motile cilium morphology (HP:0005938)3.20961243
40Lipoatrophy (HP:0100578)3.18570025
41Abnormal atrioventricular conduction (HP:0005150)3.15694761
42Dynein arm defect of respiratory motile cilia (HP:0012255)3.09947454
43Absent/shortened dynein arms (HP:0200106)3.09947454
44EMG: myopathic abnormalities (HP:0003458)3.04043630
45Myotonia (HP:0002486)2.99856527
46Rhinitis (HP:0012384)2.98307136
47Palpitations (HP:0001962)2.93264341
48Ketoacidosis (HP:0001993)2.88936929
49Neck muscle weakness (HP:0000467)2.84208344
50Abnormal EKG (HP:0003115)2.83221744
51Hyperkalemia (HP:0002153)2.76109965
52Dilated cardiomyopathy (HP:0001644)2.69321422
53Obstructive sleep apnea (HP:0002870)2.64675499
54Fetal akinesia sequence (HP:0001989)2.61224772
55Difficulty climbing stairs (HP:0003551)2.58763307
56Rimmed vacuoles (HP:0003805)2.54016908
57Increased variability in muscle fiber diameter (HP:0003557)2.52181978
58Rhabdomyolysis (HP:0003201)2.47244776
59Type 1 muscle fiber predominance (HP:0003803)2.43794327
60Ketosis (HP:0001946)2.40425062
61Protrusio acetabuli (HP:0003179)2.38810428
62Myokymia (HP:0002411)2.33201870
63Hypoglycemic coma (HP:0001325)2.32461816
64Hamartoma of the eye (HP:0010568)2.30573017
65Mildly elevated creatine phosphokinase (HP:0008180)2.24295612
66Abnormality of the foot musculature (HP:0001436)2.21534613
67Abnormality of skeletal muscle fiber size (HP:0012084)2.21149746
68Spinal rigidity (HP:0003306)2.18018005
69Foot dorsiflexor weakness (HP:0009027)2.16493828
70EMG: neuropathic changes (HP:0003445)2.15944793
71Muscle stiffness (HP:0003552)2.15153496
72Lymphangioma (HP:0100764)2.13234466
73Calcaneovalgus deformity (HP:0001848)2.12729655
74Hip contracture (HP:0003273)2.11725571
75Lower limb amyotrophy (HP:0007210)2.10916547
76Frequent falls (HP:0002359)2.10511885
77Limb-girdle muscle atrophy (HP:0003797)2.09016502
78Visual hallucinations (HP:0002367)2.07237675
79Abnormality of the nasal mucosa (HP:0000433)2.06300385
80Nasal polyposis (HP:0100582)2.05675272
81Action tremor (HP:0002345)2.04867161
82Chronic bronchitis (HP:0004469)2.04774798
83Broad metatarsal (HP:0001783)2.04666391
84Impaired social interactions (HP:0000735)2.04574785
85Abnormal social behavior (HP:0012433)2.04574785
86Bulbar palsy (HP:0001283)2.01903328
87Distal lower limb amyotrophy (HP:0008944)1.98262676
88Generalized muscle weakness (HP:0003324)1.98034937
89Focal motor seizures (HP:0011153)1.95527887
90Rapidly progressive (HP:0003678)1.93015122
91Bronchiectasis (HP:0002110)1.92886934
92Sudden cardiac death (HP:0001645)1.92561977
93Abnormality of the lower motor neuron (HP:0002366)1.91773347
94Central scotoma (HP:0000603)1.91080040
95Facial diplegia (HP:0001349)1.90998771
96Gowers sign (HP:0003391)1.89618021
97Left ventricular hypertrophy (HP:0001712)1.88257913
98Focal seizures (HP:0007359)1.87018694
99Hyperinsulinemic hypoglycemia (HP:0000825)1.86728377
100Arterial tortuosity (HP:0005116)1.86191046
101Pheochromocytoma (HP:0002666)1.84336889
102Flat acetabular roof (HP:0003180)1.83226233
103Cerebral aneurysm (HP:0004944)1.82251722
104Conjunctival hamartoma (HP:0100780)1.82203018
105Atelectasis (HP:0100750)1.82183622
106Limited hip movement (HP:0008800)1.81907442
107Postural instability (HP:0002172)1.80979589
108Proximal amyotrophy (HP:0007126)1.80880825
109Vascular tortuosity (HP:0004948)1.80469886
110Deformed tarsal bones (HP:0008119)1.78859163
111Hypoplastic ischia (HP:0003175)1.78130102
112Testicular atrophy (HP:0000029)1.77678727
113Hemiplegia (HP:0002301)1.77597526
114Hyperammonemia (HP:0001987)1.77356987
115Hypoalphalipoproteinemia (HP:0003233)1.74858170
116Muscle fiber inclusion bodies (HP:0100299)1.74230600
117Aneurysm (HP:0002617)1.73761365
118Dysdiadochokinesis (HP:0002075)1.72898001
119Hyperglycinuria (HP:0003108)1.72826779
120Hyperactive renin-angiotensin system (HP:0000841)1.72528227
121Urinary bladder sphincter dysfunction (HP:0002839)1.72502205
122Gout (HP:0001997)1.71363087
123Malignant hyperthermia (HP:0002047)1.71097399
124Aortic aneurysm (HP:0004942)1.71062628
125Genetic anticipation (HP:0003743)1.70840908
126Skin nodule (HP:0200036)1.70444744
127Poor eye contact (HP:0000817)1.70031025
128Infertility (HP:0000789)1.69511591
129Abnormality of the Achilles tendon (HP:0005109)1.69155922
130Athetosis (HP:0002305)1.68969980
131Upper limb amyotrophy (HP:0009129)1.68946867
132Achilles tendon contracture (HP:0001771)1.68758401
133Scapular winging (HP:0003691)1.66546731
134Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.65086660
135Polycythemia (HP:0001901)1.65015430
136Hyperglycemia (HP:0003074)1.64405581
137Deep venous thrombosis (HP:0002625)1.62834102
138Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62357209
139Distal lower limb muscle weakness (HP:0009053)1.62212435
140Depression (HP:0000716)1.61610549
141Palmoplantar keratoderma (HP:0000982)1.61406270
142Nonprogressive disorder (HP:0003680)1.60621341
143Abnormality of the ischium (HP:0003174)1.60513209
144Distal upper limb amyotrophy (HP:0007149)1.59671065
145Absent phalangeal crease (HP:0006109)1.59280631
146Waddling gait (HP:0002515)1.57197264
147Neurofibrillary tangles (HP:0002185)1.51630696
148Hypercortisolism (HP:0001578)1.50863842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.51958932
2LMTK23.34856600
3TTN3.16749373
4PHKG22.94642313
5PHKG12.94642313
6PKN22.65826023
7MAPK152.48428564
8DMPK2.23499274
9RIPK12.19765325
10MAP3K92.07766159
11PRKD31.84906555
12PRPF4B1.74347071
13OBSCN1.72571936
14PDK41.70954958
15PDK31.70954958
16KSR21.69629966
17MAP3K71.63052604
18SIK11.57040232
19NTRK31.56061826
20PAK61.55255876
21STK381.53829381
22TRPM71.52943901
23EPHA41.50930554
24MAP3K41.50014154
25NEK11.49913824
26TAOK11.49285331
27CAMK1G1.42297978
28DAPK21.42236626
29MYLK1.31383067
30CDK121.30077929
31PAK31.23065210
32MAP2K41.22973070
33CAMK1D1.21839290
34CAMKK11.21691894
35PDGFRA1.20760235
36PINK11.19019377
37MAP3K101.10256514
38RET1.06622518
39CDC42BPA1.05834004
40ICK1.03690835
41PTK61.02395673
42SGK31.00317650
43BCKDK1.00042680
44ERN10.99215759
45SIK20.98740578
46MARK10.98133144
47NEK90.97575076
48LATS20.97427353
49DYRK1B0.97375105
50PRKD10.96785971
51PIK3CG0.96538036
52PRKCH0.96481950
53EPHA20.96472113
54PRKAA10.95901821
55MINK10.94695101
56MAP3K60.93269392
57INSRR0.93020924
58PIK3CA0.92621272
59TYRO30.92067203
60EEF2K0.91169787
61MAPK70.90930989
62EPHA30.90252524
63NTRK20.85707140
64NTRK10.85662363
65MAP3K20.85063825
66PRKAA20.84913670
67MAPK120.83252825
68EPHB20.82030403
69FGFR40.81149862
70PDPK10.79847940
71CAMK10.77399127
72CAMK40.77083121
73PDK20.76361044
74FER0.74233978
75STK110.73702834
76LATS10.72928383
77MAP3K10.72372320
78PDK10.71692563
79MET0.71322514
80ARAF0.70007536
81KSR10.69928013
82MARK20.69659798
83WNK10.68901638
84ROCK10.67974790
85MST1R0.67973649
86CDK50.66900884
87EPHB10.66396085
88STK240.64427877
89AKT30.64168760
90ALK0.63234512
91PNCK0.62716316
92MAP2K30.61705902
93FGFR30.61176606
94JAK10.58571007
95PTK2B0.57374548
96SGK20.56678525
97TIE10.55720909
98MTOR0.54037188
99MAPK100.53895184
100SGK10.53345042
101UHMK10.53130653
102MOS0.52488907
103CAMK2D0.52408024
104TGFBR20.51933303
105ROCK20.51605641
106WNK40.50959796
107CAMK2A0.50690022
108MAPK40.50201215
109PRKD20.49061783
110MAP2K10.47798410
111PDGFRB0.47488672
112CAMK2G0.47306408
113PRKG10.46966515
114RPS6KA30.45929601
115MAP3K50.45810281
116MAP3K130.45623783
117NEK60.45441167
118PRKACG0.44905101
119RPS6KA20.44820655
120RPS6KC10.44026112
121RPS6KL10.44026112
122MAPKAPK30.43759133
123DDR20.43741479
124JAK20.42490612
125FGFR20.42314922
126MUSK0.40354629
127SGK2230.40165126
128SGK4940.40165126
129PTK20.40066222

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.89698346
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.64220782
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.50403741
4Nitrogen metabolism_Homo sapiens_hsa009102.43319641
5Dilated cardiomyopathy_Homo sapiens_hsa054142.06549584
6Fatty acid degradation_Homo sapiens_hsa000711.93032720
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.78957796
8Propanoate metabolism_Homo sapiens_hsa006401.78536882
9Cardiac muscle contraction_Homo sapiens_hsa042601.71073413
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67764635
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60823686
12Fatty acid metabolism_Homo sapiens_hsa012121.58233914
13Arginine biosynthesis_Homo sapiens_hsa002201.55659966
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46855136
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43773153
16Type II diabetes mellitus_Homo sapiens_hsa049301.42772319
17PPAR signaling pathway_Homo sapiens_hsa033201.39631916
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35900930
19Gastric acid secretion_Homo sapiens_hsa049711.35099925
20Bile secretion_Homo sapiens_hsa049761.33726152
21Insulin secretion_Homo sapiens_hsa049111.30722292
22Butanoate metabolism_Homo sapiens_hsa006501.27411804
23Circadian entrainment_Homo sapiens_hsa047131.24534949
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24275256
25Notch signaling pathway_Homo sapiens_hsa043301.22404251
26Carbon metabolism_Homo sapiens_hsa012001.20273229
27Insulin resistance_Homo sapiens_hsa049311.19334952
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17637535
29Salivary secretion_Homo sapiens_hsa049701.16773858
30Renin secretion_Homo sapiens_hsa049241.16362763
31Fatty acid biosynthesis_Homo sapiens_hsa000611.14988466
32Glucagon signaling pathway_Homo sapiens_hsa049221.14625485
33Olfactory transduction_Homo sapiens_hsa047401.13946261
34Phenylalanine metabolism_Homo sapiens_hsa003601.13704413
35Long-term potentiation_Homo sapiens_hsa047201.11523577
36Adherens junction_Homo sapiens_hsa045201.11204050
37Oxytocin signaling pathway_Homo sapiens_hsa049211.11136691
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09012342
39Histidine metabolism_Homo sapiens_hsa003401.07565351
40Tight junction_Homo sapiens_hsa045301.06994175
41Insulin signaling pathway_Homo sapiens_hsa049101.06889931
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05335828
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.04797390
44Lysine degradation_Homo sapiens_hsa003101.02678734
45Pyruvate metabolism_Homo sapiens_hsa006200.99602967
46Tryptophan metabolism_Homo sapiens_hsa003800.99530538
47Calcium signaling pathway_Homo sapiens_hsa040200.97378509
48GABAergic synapse_Homo sapiens_hsa047270.96881976
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96566777
50Axon guidance_Homo sapiens_hsa043600.95720168
51Dorso-ventral axis formation_Homo sapiens_hsa043200.95696219
52Cholinergic synapse_Homo sapiens_hsa047250.95041206
53GnRH signaling pathway_Homo sapiens_hsa049120.93893689
54Glutamatergic synapse_Homo sapiens_hsa047240.92355100
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90441512
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89582517
57Amphetamine addiction_Homo sapiens_hsa050310.88809527
58ECM-receptor interaction_Homo sapiens_hsa045120.87547121
59Starch and sucrose metabolism_Homo sapiens_hsa005000.87039010
60Inositol phosphate metabolism_Homo sapiens_hsa005620.86865544
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86420926
62cAMP signaling pathway_Homo sapiens_hsa040240.86090360
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85150336
64Morphine addiction_Homo sapiens_hsa050320.84821403
65Ovarian steroidogenesis_Homo sapiens_hsa049130.84682663
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84554477
67AMPK signaling pathway_Homo sapiens_hsa041520.84385849
68Synaptic vesicle cycle_Homo sapiens_hsa047210.84094946
69Dopaminergic synapse_Homo sapiens_hsa047280.83898541
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81201854
71Estrogen signaling pathway_Homo sapiens_hsa049150.79666160
72mTOR signaling pathway_Homo sapiens_hsa041500.78419779
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76377706
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74769213
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.72121854
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71754838
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71709977
78Fat digestion and absorption_Homo sapiens_hsa049750.70825067
79MAPK signaling pathway_Homo sapiens_hsa040100.70737019
80Glioma_Homo sapiens_hsa052140.70080693
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.70007294
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.68524425
83Gap junction_Homo sapiens_hsa045400.67176642
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.66580766
85Nicotine addiction_Homo sapiens_hsa050330.66517475
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65956435
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65807045
88Proteoglycans in cancer_Homo sapiens_hsa052050.65779507
89Glycerolipid metabolism_Homo sapiens_hsa005610.65301182
90Prion diseases_Homo sapiens_hsa050200.64547487
91Chronic myeloid leukemia_Homo sapiens_hsa052200.63514750
92beta-Alanine metabolism_Homo sapiens_hsa004100.63285801
93VEGF signaling pathway_Homo sapiens_hsa043700.63032128
94FoxO signaling pathway_Homo sapiens_hsa040680.62867523
95Viral myocarditis_Homo sapiens_hsa054160.60696393
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60581297
97Protein digestion and absorption_Homo sapiens_hsa049740.60414553
98Cocaine addiction_Homo sapiens_hsa050300.60209592
99Non-small cell lung cancer_Homo sapiens_hsa052230.59820281
100Taste transduction_Homo sapiens_hsa047420.59786142
101Pancreatic secretion_Homo sapiens_hsa049720.59728512
102B cell receptor signaling pathway_Homo sapiens_hsa046620.59222700
103Prolactin signaling pathway_Homo sapiens_hsa049170.58733176
104Rap1 signaling pathway_Homo sapiens_hsa040150.58620317
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58364343
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56467813
107Biosynthesis of amino acids_Homo sapiens_hsa012300.56045537
108Arginine and proline metabolism_Homo sapiens_hsa003300.55625169
109Focal adhesion_Homo sapiens_hsa045100.55287054
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55224703
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.53211158
112Circadian rhythm_Homo sapiens_hsa047100.52825100
113Thyroid hormone synthesis_Homo sapiens_hsa049180.50496604
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.49675133
115ABC transporters_Homo sapiens_hsa020100.48030707
116Melanogenesis_Homo sapiens_hsa049160.47239797
117Endometrial cancer_Homo sapiens_hsa052130.47159427
118ErbB signaling pathway_Homo sapiens_hsa040120.47004430
119Ras signaling pathway_Homo sapiens_hsa040140.46383509
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.45839755
121Platelet activation_Homo sapiens_hsa046110.45605670
122Other glycan degradation_Homo sapiens_hsa005110.45248408
123Amoebiasis_Homo sapiens_hsa051460.44610242
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44110154
125Long-term depression_Homo sapiens_hsa047300.42916067
126Choline metabolism in cancer_Homo sapiens_hsa052310.42858274
127Renal cell carcinoma_Homo sapiens_hsa052110.42617934
128Caffeine metabolism_Homo sapiens_hsa002320.42572935
129HIF-1 signaling pathway_Homo sapiens_hsa040660.41328757

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