TRAK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.22182163
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.08235136
3hemoglobin metabolic process (GO:0020027)5.00638663
4cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.75338596
5negative regulation of potassium ion transmembrane transport (GO:1901380)4.63448592
6erythrocyte development (GO:0048821)4.52872050
7locomotory exploration behavior (GO:0035641)4.46517664
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.36881086
9sodium ion export (GO:0071436)4.33163569
10oxygen transport (GO:0015671)4.28729054
11cell communication by electrical coupling (GO:0010644)4.22335107
12protoporphyrinogen IX biosynthetic process (GO:0006782)4.17289608
13gas transport (GO:0015669)4.09361876
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03536992
15positive regulation of receptor recycling (GO:0001921)3.98674430
16production of molecular mediator involved in inflammatory response (GO:0002532)3.98346394
17regulation of synapse structural plasticity (GO:0051823)3.98263424
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97205380
19porphyrin-containing compound biosynthetic process (GO:0006779)3.91199966
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87639022
21cardiac myofibril assembly (GO:0055003)3.85981082
22regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.84911870
23melanin biosynthetic process (GO:0042438)3.84399955
24plasma membrane repair (GO:0001778)3.84047449
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.83927980
26response to methylmercury (GO:0051597)3.83399524
27cell communication involved in cardiac conduction (GO:0086065)3.76072413
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.74511236
29cellular potassium ion homeostasis (GO:0030007)3.73637812
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.68761316
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.65984582
32potassium ion import (GO:0010107)3.63939932
33melanin metabolic process (GO:0006582)3.63641120
34myeloid cell development (GO:0061515)3.58422013
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.58053777
36activation of protein kinase A activity (GO:0034199)3.56518428
37cellular response to epinephrine stimulus (GO:0071872)3.51704616
38vocalization behavior (GO:0071625)3.51069964
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.50013858
40cardiac muscle contraction (GO:0060048)3.49886083
41macroautophagy (GO:0016236)3.49542906
42glutamate secretion (GO:0014047)3.46656787
43regulation of membrane repolarization (GO:0060306)3.45871989
44response to epinephrine (GO:0071871)3.40446130
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.39680503
46layer formation in cerebral cortex (GO:0021819)3.39265445
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37642546
48regulation of integrin-mediated signaling pathway (GO:2001044)3.35130364
49synaptic vesicle exocytosis (GO:0016079)3.34864046
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34807540
51iron ion import (GO:0097286)3.34130493
52sarcomere organization (GO:0045214)3.33464218
53heart process (GO:0003015)3.32677022
54heart contraction (GO:0060047)3.32677022
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28837352
56regulation of synaptic vesicle exocytosis (GO:2000300)3.28795953
57myofibril assembly (GO:0030239)3.25328023
58regulation of glutamate receptor signaling pathway (GO:1900449)3.24609028
59tetrapyrrole biosynthetic process (GO:0033014)3.24409561
60positive regulation of fibroblast migration (GO:0010763)3.22153457
61proline transport (GO:0015824)3.21614926
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11287198
63neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.04163302
64actin filament capping (GO:0051693)3.03474525
65negative regulation of protein localization to plasma membrane (GO:1903077)3.03203073
66cortical actin cytoskeleton organization (GO:0030866)3.03129850
67neurotransmitter secretion (GO:0007269)3.03116146
68regulation of synaptic vesicle transport (GO:1902803)3.02711968
69regulation of ARF protein signal transduction (GO:0032012)3.01797478
70regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01596212
71porphyrin-containing compound metabolic process (GO:0006778)3.01513373
72protein localization to endosome (GO:0036010)2.98236775
73negative regulation of potassium ion transport (GO:0043267)2.97511163
74regulation of calcium ion transmembrane transport (GO:1903169)2.97036548
75regulation of calcium ion transmembrane transporter activity (GO:1901019)2.97036548
76positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.96133040
77regulation of clathrin-mediated endocytosis (GO:2000369)2.95479088
78positive regulation of potassium ion transmembrane transport (GO:1901381)2.95170006
79exploration behavior (GO:0035640)2.93649506
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.92947465
81regulation of neuronal synaptic plasticity (GO:0048168)2.92448723
82protein targeting to plasma membrane (GO:0072661)2.89268947
83regulation of dendritic spine morphogenesis (GO:0061001)2.88796095
84regulation of receptor recycling (GO:0001919)2.85251414
85establishment of nucleus localization (GO:0040023)2.84110227
86striatum development (GO:0021756)2.83710637
87neuromuscular process controlling balance (GO:0050885)2.82732736
88regulation of cell communication by electrical coupling (GO:0010649)2.82510442
89membrane repolarization (GO:0086009)2.82029100
90membrane depolarization during action potential (GO:0086010)2.81201737
91regulation of potassium ion transmembrane transporter activity (GO:1901016)2.79155189
92regulation of response to osmotic stress (GO:0047484)2.78354355
93glycine transport (GO:0015816)2.77733463
94ventricular cardiac muscle cell action potential (GO:0086005)2.77546634
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76695879
96regulation of actin filament-based movement (GO:1903115)2.76368356
97regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.75711690
98negative regulation of anoikis (GO:2000811)2.73769190
99regulation of potassium ion transmembrane transport (GO:1901379)2.72835715
100protoporphyrinogen IX metabolic process (GO:0046501)2.72635274
101cellular response to nerve growth factor stimulus (GO:1990090)2.72590649
102response to nerve growth factor (GO:1990089)2.72590649
103cellular response to thyroid hormone stimulus (GO:0097067)2.72538620
104cardiac conduction (GO:0061337)2.72118920
105regulation of voltage-gated calcium channel activity (GO:1901385)2.71566496
106regulation of platelet aggregation (GO:0090330)2.71329196
107G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70834405
108cell migration involved in heart development (GO:0060973)2.70597970
109protein localization to synapse (GO:0035418)2.69664060
110cellular sodium ion homeostasis (GO:0006883)2.69512952
111positive regulation of sodium ion transport (GO:0010765)2.68568719
112extracellular fibril organization (GO:0043206)2.68211509
113striated muscle contraction (GO:0006941)2.68167972
114secondary metabolite biosynthetic process (GO:0044550)2.68165924
115potassium ion homeostasis (GO:0055075)2.67887314
116cardiac muscle hypertrophy (GO:0003300)2.67300729
117long-term memory (GO:0007616)2.66888937
118positive regulation of macroautophagy (GO:0016239)2.65624529
119neuronal action potential propagation (GO:0019227)2.65398148
120cell volume homeostasis (GO:0006884)2.65182189
121ionotropic glutamate receptor signaling pathway (GO:0035235)2.65055161
122hepatocyte apoptotic process (GO:0097284)2.65001100
123tricarboxylic acid cycle (GO:0006099)2.64496962
124positive regulation of Rap GTPase activity (GO:0032854)2.64338423
125cortical cytoskeleton organization (GO:0030865)2.64315822
126barbed-end actin filament capping (GO:0051016)2.63788168
127dendritic spine morphogenesis (GO:0060997)2.63419246
128prepulse inhibition (GO:0060134)2.63237370
129nuclear pore organization (GO:0006999)2.63202295
130erythrocyte maturation (GO:0043249)2.62771996
131relaxation of cardiac muscle (GO:0055119)2.61518068
132regulation of Rap GTPase activity (GO:0032317)2.60876973
133detection of calcium ion (GO:0005513)2.60255276
134heme biosynthetic process (GO:0006783)2.60151146
135vesicle transport along microtubule (GO:0047496)2.60065780
136membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.59486663
137sarcoplasmic reticulum calcium ion transport (GO:0070296)2.59205602
138neurotransmitter-gated ion channel clustering (GO:0072578)2.58803270
139positive regulation of potassium ion transport (GO:0043268)2.58552514
140striated muscle hypertrophy (GO:0014897)2.57750228
141cardiac muscle cell action potential (GO:0086001)2.57705982
142cardiac muscle cell action potential involved in contraction (GO:0086002)2.57650983
143regulation of ion transmembrane transporter activity (GO:0032412)2.57589198
144regulation of cation channel activity (GO:2001257)2.56487027
145fibril organization (GO:0097435)2.56350194
146negative regulation of actin filament depolymerization (GO:0030835)2.55428967
147regulation of the force of heart contraction (GO:0002026)2.55247209
148megakaryocyte development (GO:0035855)2.54217033
149positive regulation of synapse maturation (GO:0090129)2.53984327
150stress fiber assembly (GO:0043149)2.52628244
151calcium-mediated signaling using intracellular calcium source (GO:0035584)2.52627126
152nerve growth factor signaling pathway (GO:0038180)2.51763518
153negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.46841884
154response to lead ion (GO:0010288)2.43463009
155clathrin coat assembly (GO:0048268)2.42784382
156Rap protein signal transduction (GO:0032486)2.41847709
157regulation of early endosome to late endosome transport (GO:2000641)2.32838269
158cellular response to monoamine stimulus (GO:0071868)2.31093100
159cellular response to catecholamine stimulus (GO:0071870)2.31093100
160actin-myosin filament sliding (GO:0033275)2.30864328
161muscle filament sliding (GO:0030049)2.30864328
162striated muscle atrophy (GO:0014891)2.28544442
163regulation of nucleobase-containing compound transport (GO:0032239)2.25942083
164response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.25882477
165very-low-density lipoprotein particle assembly (GO:0034379)2.25590629
166regulation of anoikis (GO:2000209)2.25117586
167phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.25004239
168membrane raft organization (GO:0031579)2.24944193
169actomyosin structure organization (GO:0031032)2.24670719
170actin-mediated cell contraction (GO:0070252)2.24262966
171regulation of translation, ncRNA-mediated (GO:0045974)2.23869182
172negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.23869182
173negative regulation of translation, ncRNA-mediated (GO:0040033)2.23869182
174definitive hemopoiesis (GO:0060216)2.23619478
175response to catecholamine (GO:0071869)2.23285585
176response to monoamine (GO:0071867)2.23285585
177negative regulation of adherens junction organization (GO:1903392)2.23153263
178negative regulation of focal adhesion assembly (GO:0051895)2.23153263
179negative regulation of cell junction assembly (GO:1901889)2.23153263
180cellular response to reactive nitrogen species (GO:1902170)2.19509453
181embryonic process involved in female pregnancy (GO:0060136)2.19483809
182negative regulation of erythrocyte differentiation (GO:0045647)2.18703422
183actin filament-based movement (GO:0030048)2.18370453
184import into cell (GO:0098657)2.17788799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.62728593
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.24159978
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09065968
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.92611357
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58056564
6DROSHA_22980978_ChIP-Seq_HELA_Human2.46049718
7GATA2_21666600_ChIP-Seq_HMVEC_Human2.39754255
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27842883
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27456312
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15891948
11KDM2B_26808549_Chip-Seq_K562_Human2.12634102
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10314568
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.07748379
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05665606
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05665606
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02971367
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02250927
18SCL_19346495_ChIP-Seq_HPC-7_Human2.00471470
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96277691
20GATA1_19941826_ChIP-Seq_K562_Human1.90392299
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.90184591
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84752582
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81560942
24REST_21632747_ChIP-Seq_MESCs_Mouse1.77923670
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76995005
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74418163
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73136770
28KDM2B_26808549_Chip-Seq_DND41_Human1.71196785
29EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.70171418
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69932954
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69745814
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.68422312
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67571740
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67002475
35* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66879681
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65382666
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64183768
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63654044
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.62901184
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62804930
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62725739
42* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61446681
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60751378
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60623451
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60559704
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58983384
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58537573
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.57652112
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56946054
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52681154
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52681154
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50298218
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.49788056
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.49434607
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49251930
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48937126
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.48847637
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.48549006
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.48528016
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48144426
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47664683
62RUNX_20019798_ChIP-Seq_JUKART_Human1.45781354
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45530468
64* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45516498
65CLOCK_20551151_ChIP-Seq_293T_Human1.45384193
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43858346
67ZNF263_19887448_ChIP-Seq_K562_Human1.41373478
68BRD4_25478319_ChIP-Seq_HGPS_Human1.40726162
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40577570
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.40387240
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.40387240
72TP53_16413492_ChIP-PET_HCT116_Human1.39554066
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39313889
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38550836
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37449462
76* GATA1_19941827_ChIP-Seq_MEL_Mouse1.35595042
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35211545
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33463669
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32502570
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.32217900
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.30595213
82CJUN_26792858_Chip-Seq_BT549_Human1.30080129
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29993771
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.29218010
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26147679
86LXR_22292898_ChIP-Seq_THP-1_Human1.25740071
87TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.25207364
88* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24664232
89AR_19668381_ChIP-Seq_PC3_Human1.23382826
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23324546
91AR_21572438_ChIP-Seq_LNCaP_Human1.21554757
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21223848
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.20184128
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.19154082
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17940965
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17940965
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17255667
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17083802
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16050067
100* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15722856
101TCF7_22412390_ChIP-Seq_EML_Mouse1.15595819
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14885121
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14091780
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14086080
105SMC4_20622854_ChIP-Seq_HELA_Human1.13882321
106* GATA2_19941826_ChIP-Seq_K562_Human1.13844513
107GBX2_23144817_ChIP-Seq_PC3_Human1.13699097
108* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13676070
109GATA1_22025678_ChIP-Seq_K562_Human1.13341198
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13086761
111GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11384860
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10797035
113IRF8_27001747_Chip-Seq_BMDM_Mouse1.10139150
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10120250
115* LXR_22158963_ChIP-Seq_LIVER_Mouse1.08817095
116CREB1_26743006_Chip-Seq_LNCaP_Human1.08684678
117KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08369821
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08018787
119BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07486648
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.07364397
121* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06223698
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.05448805
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05297602
124P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04975959
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04723925
126CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04133256
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04012985
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03488049
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02464973
130VDR_24787735_ChIP-Seq_THP-1_Human1.02281341
131CTCF_27219007_Chip-Seq_Bcells_Human1.01702098
132EED_16625203_ChIP-ChIP_MESCs_Mouse1.01292079
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00905828
134SMAD4_21741376_ChIP-Seq_HESCs_Human1.00412195
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99926940
136* PU_27001747_Chip-Seq_BMDM_Mouse0.99457220
137AHR_22903824_ChIP-Seq_MCF-7_Human0.96927401
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96880056
139* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96231620
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96198323
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.95386708
142SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93814433
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.93707506
144RING1B_27294783_Chip-Seq_NPCs_Mouse0.93442904
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.93201835
146SMAD4_21799915_ChIP-Seq_A2780_Human0.91772246
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91692296
148SPI1_23127762_ChIP-Seq_K562_Human0.91571738
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91462718
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90835362
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90807117
152ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90621319
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90489127
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90346453
155OCT4_19829295_ChIP-Seq_ESCs_Human0.90324499
156PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89646844
157PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89523039
158* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87958942
159* TP63_23658742_ChIP-Seq_EP156T_Human0.86547400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.09390368
2MP0008438_abnormal_cutaneous_collagen4.40421466
3MP0002837_dystrophic_cardiac_calcinosis3.75507923
4MP0004084_abnormal_cardiac_muscle3.36012297
5MP0005171_absent_coat_pigmentation3.35568723
6MP0000751_myopathy3.29703390
7MP0004215_abnormal_myocardial_fiber3.29555250
8MP0003646_muscle_fatigue2.93898723
9MP0002822_catalepsy2.91549031
10MP0002877_abnormal_melanocyte_morpholog2.83797959
11MP0003635_abnormal_synaptic_transmissio2.79389604
12MP0000015_abnormal_ear_pigmentation2.66765184
13MP0000569_abnormal_digit_pigmentation2.62459305
14MP0004036_abnormal_muscle_relaxation2.50934826
15MP0000749_muscle_degeneration2.38085679
16MP0003950_abnormal_plasma_membrane2.32920586
17MP0004270_analgesia2.32037080
18MP0005275_abnormal_skin_tensile2.30884862
19MP0005409_darkened_coat_color2.27447114
20MP0005330_cardiomyopathy2.26775653
21MP0001958_emphysema2.24183072
22MP0000372_irregular_coat_pigmentation2.14113791
23MP0008775_abnormal_heart_ventricle2.14055277
24MP0002063_abnormal_learning/memory/cond2.13167917
25MP0002909_abnormal_adrenal_gland2.08059861
26MP0009745_abnormal_behavioral_response2.07731927
27MP0004087_abnormal_muscle_fiber2.07021982
28MP0003137_abnormal_impulse_conducting2.02884211
29MP0008260_abnormal_autophagy2.02796443
30MP0003566_abnormal_cell_adhesion2.01198159
31MP0004130_abnormal_muscle_cell2.00734822
32MP0003656_abnormal_erythrocyte_physiolo1.99352073
33MP0008961_abnormal_basal_metabolism1.99039981
34MP0002064_seizures1.99019570
35MP0003880_abnormal_central_pattern1.98448154
36MP0002972_abnormal_cardiac_muscle1.97850222
37MP0005083_abnormal_biliary_tract1.97849666
38MP0005408_hypopigmentation1.97729599
39MP0009046_muscle_twitch1.97422463
40MP0004085_abnormal_heartbeat1.95738801
41MP0003279_aneurysm1.93847522
42MP0005620_abnormal_muscle_contractility1.91098248
43MP0003172_abnormal_lysosome_physiology1.81782561
44MP0004484_altered_response_of1.81302358
45MP0004858_abnormal_nervous_system1.78183407
46MP0003191_abnormal_cellular_cholesterol1.76653531
47MP0003091_abnormal_cell_migration1.76219391
48MP0004147_increased_porphyrin_level1.69599114
49MP0000747_muscle_weakness1.66295727
50MP0004145_abnormal_muscle_electrophysio1.64019359
51MP0009780_abnormal_chondrocyte_physiolo1.63329608
52MP0002269_muscular_atrophy1.62240541
53MP0000371_diluted_coat_color1.59319776
54MP0001486_abnormal_startle_reflex1.58430758
55MP0008569_lethality_at_weaning1.56655404
56MP0004043_abnormal_pH_regulation1.55322988
57MP0010630_abnormal_cardiac_muscle1.55131473
58MP0003705_abnormal_hypodermis_morpholog1.54676681
59MP0005257_abnormal_intraocular_pressure1.54235672
60MP0005503_abnormal_tendon_morphology1.53283075
61MP0005451_abnormal_body_composition1.52803561
62MP0004233_abnormal_muscle_weight1.52756784
63MP0002572_abnormal_emotion/affect_behav1.52647061
64MP0002272_abnormal_nervous_system1.50991908
65MP0001544_abnormal_cardiovascular_syste1.44953924
66MP0005385_cardiovascular_system_phenoty1.44953924
67MP0002106_abnormal_muscle_physiology1.43039193
68MP0002734_abnormal_mechanical_nocicepti1.42622224
69MP0005623_abnormal_meninges_morphology1.42596583
70MP0002332_abnormal_exercise_endurance1.41460790
71MP0004510_myositis1.40687333
72MP0005464_abnormal_platelet_physiology1.39240724
73MP0000759_abnormal_skeletal_muscle1.38885609
74MP0003303_peritoneal_inflammation1.36489833
75MP0001968_abnormal_touch/_nociception1.36079367
76MP0001849_ear_inflammation1.32318161
77MP0006138_congestive_heart_failure1.30120441
78MP0002095_abnormal_skin_pigmentation1.29609557
79MP0000750_abnormal_muscle_regeneration1.28252869
80MP0003329_amyloid_beta_deposits1.26380389
81MP0004811_abnormal_neuron_physiology1.24576724
82MP0004924_abnormal_behavior1.23838849
83MP0005386_behavior/neurological_phenoty1.23838849
84MP0004272_abnormal_basement_membrane1.23794783
85MP0004883_abnormal_blood_vessel1.23308372
86MP0005423_abnormal_somatic_nervous1.22875004
87MP0005167_abnormal_blood-brain_barrier1.20566967
88MP0004381_abnormal_hair_follicle1.20359020
89MP0005369_muscle_phenotype1.18179571
90MP0001501_abnormal_sleep_pattern1.15845826
91MP0003633_abnormal_nervous_system1.13938410
92MP0004885_abnormal_endolymph1.13883202
93MP0005174_abnormal_tail_pigmentation1.13557519
94MP0001851_eye_inflammation1.12770307
95MP0006054_spinal_hemorrhage1.12226413
96MP0001440_abnormal_grooming_behavior1.11809091
97MP0010352_gastrointestinal_tract_polyps1.11745089
98MP0005551_abnormal_eye_electrophysiolog1.11547464
99MP0002067_abnormal_sensory_capabilities1.10477509
100MP0000013_abnormal_adipose_tissue1.10251055
101MP0002166_altered_tumor_susceptibility1.06891836
102MP0005058_abnormal_lysosome_morphology1.05947824
103MP0002127_abnormal_cardiovascular_syste1.04746646
104MP0000767_abnormal_smooth_muscle1.04134702
105MP0005075_abnormal_melanosome_morpholog1.03343181
106MP0005164_abnormal_response_to1.02047199
107MP0001970_abnormal_pain_threshold1.01253515
108MP0010368_abnormal_lymphatic_system1.01000688
109MP0005397_hematopoietic_system_phenotyp1.00009610
110MP0001545_abnormal_hematopoietic_system1.00009610
111MP0002733_abnormal_thermal_nociception0.98423100
112MP0002009_preneoplasia0.95915631
113MP0004808_abnormal_hematopoietic_stem0.94492554
114MP0003045_fibrosis0.94296923
115MP0003221_abnormal_cardiomyocyte_apopto0.94273315
116MP0008874_decreased_physiological_sensi0.93626291
117MP0005023_abnormal_wound_healing0.93032989
118MP0002090_abnormal_vision0.91525394
119MP0010234_abnormal_vibrissa_follicle0.91476749
120MP0001915_intracranial_hemorrhage0.90657518
121MP0000733_abnormal_muscle_development0.89322061
122MP0002066_abnormal_motor_capabilities/c0.88825359
123MP0003075_altered_response_to0.88685925
124MP0003283_abnormal_digestive_organ0.88448951
125MP0002060_abnormal_skin_morphology0.88286536
126MP0002128_abnormal_blood_circulation0.87975602
127MP0000003_abnormal_adipose_tissue0.87467121
128MP0002735_abnormal_chemical_nociception0.87246455
129MP0005666_abnormal_adipose_tissue0.87195502
130MP0002998_abnormal_bone_remodeling0.84993930
131MP0000955_abnormal_spinal_cord0.84524000
132MP0001542_abnormal_bone_strength0.84497576
133MP0005165_increased_susceptibility_to0.84222569
134MP0000465_gastrointestinal_hemorrhage0.84211765
135MP0002882_abnormal_neuron_morphology0.83925802
136MP0008004_abnormal_stomach_pH0.82832884
137MP0003631_nervous_system_phenotype0.82215321
138MP0002295_abnormal_pulmonary_circulatio0.81272725
139MP0002229_neurodegeneration0.81046849
140MP0005375_adipose_tissue_phenotype0.80772408
141MP0003453_abnormal_keratinocyte_physiol0.80749537
142MP0003828_pulmonary_edema0.80343878
143MP0005535_abnormal_body_temperature0.80247014
144MP0005499_abnormal_olfactory_system0.80217521
145MP0005394_taste/olfaction_phenotype0.80217521
146MP0006035_abnormal_mitochondrial_morpho0.79753813
147MP0002234_abnormal_pharynx_morphology0.78411222
148MP0004185_abnormal_adipocyte_glucose0.78044982
149MP0002896_abnormal_bone_mineralization0.77933557
150MP0003787_abnormal_imprinting0.77559409
151MP0000266_abnormal_heart_morphology0.77421000
152MP0002736_abnormal_nociception_after0.76770862
153MP0009840_abnormal_foam_cell0.76540568
154MP0008872_abnormal_physiological_respon0.75692698
155MP0003690_abnormal_glial_cell0.75576158
156MP0002133_abnormal_respiratory_system0.75391751
157MP0005388_respiratory_system_phenotype0.75391751
158MP0000343_altered_response_to0.74728642
159MP0003879_abnormal_hair_cell0.73967309
160MP0002184_abnormal_innervation0.73651832
161MP0003300_gastrointestinal_ulcer0.72984085
162MP0005595_abnormal_vascular_smooth0.70486813
163MP0005621_abnormal_cell_physiology0.69169600
164MP0009384_cardiac_valve_regurgitation0.68695130
165MP0002971_abnormal_brown_adipose0.67921008
166MP0002108_abnormal_muscle_morphology0.67849026
167MP0000920_abnormal_myelination0.66504861

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.84344591
2Abnormality of the heme biosynthetic pathway (HP:0010472)4.74877402
3Exercise-induced muscle cramps (HP:0003710)3.97455717
4Bundle branch block (HP:0011710)3.93810696
5Myokymia (HP:0002411)3.89104427
6Atrial fibrillation (HP:0005110)3.82874257
7Exercise-induced myalgia (HP:0003738)3.77332136
8Focal motor seizures (HP:0011153)3.73123591
9Primary atrial arrhythmia (HP:0001692)3.66724733
10Aortic aneurysm (HP:0004942)3.66122599
11Arterial tortuosity (HP:0005116)3.63335674
12Difficulty running (HP:0009046)3.61221354
13Vascular tortuosity (HP:0004948)3.60819138
14Protrusio acetabuli (HP:0003179)3.57322407
15Ventricular fibrillation (HP:0001663)3.48208458
16Focal seizures (HP:0007359)3.46784536
17Supraventricular tachycardia (HP:0004755)3.46109818
18Supraventricular arrhythmia (HP:0005115)3.40425415
19Osteolytic defects of the hand bones (HP:0009699)3.35969814
20Osteolytic defects of the phalanges of the hand (HP:0009771)3.35969814
21Ventricular tachycardia (HP:0004756)3.33264137
22Visual hallucinations (HP:0002367)3.31945875
23Abnormality of the lower motor neuron (HP:0002366)3.27332402
24Hypochromic microcytic anemia (HP:0004840)3.20297785
25Resting tremor (HP:0002322)3.19574118
26Dysmetric saccades (HP:0000641)3.19480184
27Prolonged QT interval (HP:0001657)3.18568785
28Premature rupture of membranes (HP:0001788)3.17492102
29Hyporeflexia of lower limbs (HP:0002600)3.13607202
30Calf muscle hypertrophy (HP:0008981)3.12686450
31Syncope (HP:0001279)3.10474248
32Polycythemia (HP:0001901)3.06532507
33Microcytic anemia (HP:0001935)2.95988112
34Aortic dissection (HP:0002647)2.95479395
35Abnormality of the calf musculature (HP:0001430)2.94707745
36Abnormal gallbladder physiology (HP:0012438)2.89855216
37Cholecystitis (HP:0001082)2.89855216
38Subaortic stenosis (HP:0001682)2.87444181
39Abnormality of the left ventricular outflow tract (HP:0011103)2.87444181
40Heart block (HP:0012722)2.85329039
41Ocular albinism (HP:0001107)2.85006187
42Depression (HP:0000716)2.84848590
43Muscle hypertrophy of the lower extremities (HP:0008968)2.84040567
44Poikilocytosis (HP:0004447)2.83902696
45Myoglobinuria (HP:0002913)2.83121592
46Muscle fiber splitting (HP:0003555)2.82588525
47Ventricular arrhythmia (HP:0004308)2.82050217
48Cerebral aneurysm (HP:0004944)2.80824538
49Atrioventricular block (HP:0001678)2.80366257
50Increased connective tissue (HP:0009025)2.75409995
51Central scotoma (HP:0000603)2.75297766
52Insomnia (HP:0100785)2.74026099
53Spondylolisthesis (HP:0003302)2.71968407
54Abnormal atrioventricular conduction (HP:0005150)2.71701804
55Abnormal EKG (HP:0003115)2.71258705
56Lower limb amyotrophy (HP:0007210)2.69953715
57Action tremor (HP:0002345)2.67691072
58Impaired social interactions (HP:0000735)2.65637298
59Abnormal social behavior (HP:0012433)2.65637298
60Hypoplasia of the iris (HP:0007676)2.61601467
61EMG: myopathic abnormalities (HP:0003458)2.61327399
62Dysdiadochokinesis (HP:0002075)2.58873266
63Febrile seizures (HP:0002373)2.54932037
64Postural instability (HP:0002172)2.54695109
65Poor eye contact (HP:0000817)2.49950713
66Epileptic encephalopathy (HP:0200134)2.49446272
67Increased variability in muscle fiber diameter (HP:0003557)2.46690816
68Blue irides (HP:0000635)2.45857063
69Myotonia (HP:0002486)2.45814941
70Generalized tonic-clonic seizures (HP:0002069)2.43986742
71Wormian bones (HP:0002645)2.43075845
72Cholelithiasis (HP:0001081)2.41906578
73Reticulocytosis (HP:0001923)2.40137030
74Urinary urgency (HP:0000012)2.35658769
75Iris hypopigmentation (HP:0007730)2.31619876
76Scotoma (HP:0000575)2.31205347
77Cerebral inclusion bodies (HP:0100314)2.28850383
78Impaired vibration sensation in the lower limbs (HP:0002166)2.28443815
79Type 1 muscle fiber predominance (HP:0003803)2.26958685
80Acanthocytosis (HP:0001927)2.26709952
81Atonic seizures (HP:0010819)2.26041733
82Absence seizures (HP:0002121)2.24670467
83Upper limb amyotrophy (HP:0009129)2.24292377
84Distal upper limb amyotrophy (HP:0007149)2.24292377
85Distal lower limb muscle weakness (HP:0009053)2.23531322
86Right ventricular cardiomyopathy (HP:0011663)2.22772939
87Rapidly progressive (HP:0003678)2.22563302
88Papillary thyroid carcinoma (HP:0002895)2.22129850
89Urinary bladder sphincter dysfunction (HP:0002839)2.21690189
90Anxiety (HP:0000739)2.20362229
91Aneurysm (HP:0002617)2.19405067
92Overgrowth (HP:0001548)2.19204772
93Gingival bleeding (HP:0000225)2.19067619
94Dialeptic seizures (HP:0011146)2.19026202
95Distal lower limb amyotrophy (HP:0008944)2.18171807
96Lipoatrophy (HP:0100578)2.17984328
97Difficulty climbing stairs (HP:0003551)2.17646121
98Mitral stenosis (HP:0001718)2.15533510
99Hamartoma of the eye (HP:0010568)2.14386183
100Papilledema (HP:0001085)2.13843190
101Dilatation of the ascending aorta (HP:0005111)2.10997012
102White forelock (HP:0002211)2.10285390
103Macroorchidism (HP:0000053)2.08755410
104Achilles tendon contracture (HP:0001771)2.08721792
105Abnormality of skeletal muscle fiber size (HP:0012084)2.06890072
106Prolonged bleeding time (HP:0003010)2.06293389
107Mitral valve prolapse (HP:0001634)2.05604729
108Asymmetric septal hypertrophy (HP:0001670)2.05420157
109EMG: neuropathic changes (HP:0003445)2.03250588
110Ankle clonus (HP:0011448)2.03214186
111Lymphangioma (HP:0100764)2.01395122
112Abnormal gallbladder morphology (HP:0012437)2.00514300
113Spontaneous hematomas (HP:0007420)1.99726114
114Increased mean platelet volume (HP:0011877)1.99342274
115Hemiplegia (HP:0002301)1.97978213
116Supranuclear gaze palsy (HP:0000605)1.97450272
117Aplasia/Hypoplasia of the macula (HP:0008059)1.96987549
118Neoplasm of the heart (HP:0100544)1.96549214
119Dysmetria (HP:0001310)1.95592865
120Peritonitis (HP:0002586)1.95246973
121Termporal pattern (HP:0011008)1.93931296
122Insidious onset (HP:0003587)1.93931296
123Striae distensae (HP:0001065)1.93198848
124Diaphragmatic weakness (HP:0009113)1.92834072
125Dilated cardiomyopathy (HP:0001644)1.92624287
126Decreased motor nerve conduction velocity (HP:0003431)1.91036164
127Status epilepticus (HP:0002133)1.89945008
128Annular pancreas (HP:0001734)1.89675623
129Mucopolysacchariduria (HP:0008155)1.89154263
130Urinary glycosaminoglycan excretion (HP:0003541)1.89154263
131Abnormality of the Achilles tendon (HP:0005109)1.87857691
132Truncal ataxia (HP:0002078)1.87702202
133Intention tremor (HP:0002080)1.86871366
134Mildly elevated creatine phosphokinase (HP:0008180)1.86073923
135Testicular atrophy (HP:0000029)1.85843856
136Neonatal hypoglycemia (HP:0001998)1.85221135
137Delayed closure of the anterior fontanelle (HP:0001476)1.83160692
138Abnormal platelet volume (HP:0011876)1.82240769
139Subacute progressive viral hepatitis (HP:0006572)1.81019346
140Abnormality of polysaccharide metabolism (HP:0011012)1.80684236
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80684236
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80684236
143Soft skin (HP:0000977)1.80453778
144Foot dorsiflexor weakness (HP:0009027)1.79161680
145Fragile skin (HP:0001030)1.78065022
146Aplasia/Hypoplasia affecting the retina (HP:0008061)1.77299916
147Horizontal nystagmus (HP:0000666)1.77193528
148Pointed chin (HP:0000307)1.77189713
149Frequent falls (HP:0002359)1.77037859
150Dysostosis multiplex (HP:0000943)1.76210254
151Hypopigmentation of the fundus (HP:0007894)1.76166188
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75734372
153Progressive cerebellar ataxia (HP:0002073)1.75731954
154Patchy hypopigmentation of hair (HP:0011365)1.75417323
155Testicular neoplasm (HP:0010788)1.73336989
156Slow saccadic eye movements (HP:0000514)1.73273253
157Muscle stiffness (HP:0003552)1.72540800
158Absent frontal sinuses (HP:0002688)1.71979471
159Paralysis (HP:0003470)1.71948015
160Obstructive sleep apnea (HP:0002870)1.70397376
161Amblyopia (HP:0000646)1.69840625
162Bradykinesia (HP:0002067)1.69819449
163Hypercortisolism (HP:0001578)1.69279816
164Orthostatic hypotension (HP:0001278)1.68234863
165Epistaxis (HP:0000421)1.65885313
166Abnormality of the gallbladder (HP:0005264)1.65701227
167Toxemia of pregnancy (HP:0100603)1.65266559
168Abnormality of the foot musculature (HP:0001436)1.65075596
169Mild short stature (HP:0003502)1.62923458
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62470960
171Albinism (HP:0001022)1.61955595
172Vertebral compression fractures (HP:0002953)1.61931042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.24719195
2EIF2AK13.03945439
3MAP3K92.72538081
4NTRK32.63207674
5TRIB32.56672856
6MUSK2.46576902
7TTN2.27871597
8CDK122.19945851
9MAP3K32.15584191
10LMTK22.14857102
11PRKD32.14381876
12MAP2K32.14027059
13KSR22.01265186
14PKN22.00998425
15PHKG22.00420956
16PHKG12.00420956
17NEK11.98233592
18PAK61.95262194
19GRK51.92721099
20DAPK21.88807513
21TRPM71.85474243
22RIPK11.82778389
23NEK91.79826683
24CAMKK11.78971499
25STK381.78265385
26MAP3K41.76603930
27DMPK1.74527454
28WNK11.72895503
29TYRO31.57930902
30TAOK11.56389783
31STK41.56201961
32NTRK11.52447462
33MINK11.50553571
34PINK11.49538927
35MAP2K41.44715517
36MAP3K71.35135161
37PDK41.31237011
38PDK31.31237011
39PRKCH1.31179835
40IRAK31.24518223
41SGK31.19886954
42JAK11.17956552
43MARK11.17261858
44PDGFRA1.15856053
45MAP3K61.15276926
46OBSCN1.15258934
47ZAP701.13381258
48PAK31.13338923
49DDR21.13084855
50ALK1.12698425
51TAOK21.12062207
52MARK31.11917774
53SIK21.08647601
54CDK51.05557723
55RET1.05456060
56MAP3K51.05350414
57NTRK21.00828273
58CAMK41.00654343
59PIK3CG0.99471393
60CAMK1G0.99064386
61GRK60.98826986
62AKT30.98396007
63CDC42BPA0.98335813
64KSR10.94461617
65RPS6KA20.93025444
66PDK10.92875239
67SGK4940.89464639
68SGK2230.89464639
69MARK20.89042474
70STK240.87191789
71PRKAA20.86559552
72MAP3K20.83865343
73MELK0.83547278
74PRKAA10.83252878
75STK110.83046902
76RIPK40.82660912
77CAMK10.82388459
78PLK20.81969789
79SGK20.81300215
80PDPK10.81008262
81PRKD10.80699466
82MET0.80071750
83SGK10.79721165
84MAPK120.79629842
85CAMK1D0.78224057
86SCYL20.73651132
87FGFR40.72352507
88MTOR0.72064689
89PTK2B0.70862975
90IKBKE0.69255744
91CDK60.68941069
92WNK40.67803098
93PIM10.67177604
94CAMKK20.64089856
95CLK10.63924450
96RPS6KA30.63554459
97GRK70.63177982
98MAP3K100.62779046
99STK30.61977365
100LATS10.61904462
101BMX0.61897317
102PTK20.61324097
103UHMK10.61265829
104JAK20.60991533
105BLK0.60620096
106EPHB10.60394469
107TGFBR20.60069177
108FGR0.60004452
109SYK0.59306840
110MAPK70.59230255
111ERN10.58465779
112DAPK10.58222231
113TYK20.57623154
114PDK20.56940649
115CCNB10.55801540
116LATS20.55127895
117PAK20.54277544
118NLK0.53140302
119MAPK110.51283691
120FES0.50989335
121MAP3K130.50987304
122CDK150.48594357
123FGFR30.48411321
124ROCK20.48041073
125ROCK10.47867348
126CAMK2A0.47340194
127SIK10.46983205
128PRKCG0.46852364
129PRKD20.46464075
130DAPK30.45801958
131PRKACG0.45688887
132MAP3K10.45345574
133ICK0.45298636
134MAPK100.44422560
135RAF10.44288564
136CDK180.43020845
137PDGFRB0.42547732
138CAMK2D0.41644823
139PIK3CA0.40877230
140MAP2K10.40651730
141PRPF4B0.40144187
142CDK140.39733983
143HIPK20.39668051
144MYLK0.38494936

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.20001514
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15630759
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08851462
4Dilated cardiomyopathy_Homo sapiens_hsa054142.08153384
5Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.07006207
6Long-term potentiation_Homo sapiens_hsa047201.92934527
7Synaptic vesicle cycle_Homo sapiens_hsa047211.92663147
8Circadian entrainment_Homo sapiens_hsa047131.91346368
9Nitrogen metabolism_Homo sapiens_hsa009101.81866315
10* GABAergic synapse_Homo sapiens_hsa047271.76584969
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75004161
12Morphine addiction_Homo sapiens_hsa050321.72922393
13Glutamatergic synapse_Homo sapiens_hsa047241.71745089
14Cardiac muscle contraction_Homo sapiens_hsa042601.70525520
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.69898577
16Gastric acid secretion_Homo sapiens_hsa049711.67507551
17Nicotine addiction_Homo sapiens_hsa050331.64305739
18Pancreatic cancer_Homo sapiens_hsa052121.63357956
19Salivary secretion_Homo sapiens_hsa049701.62746837
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60813482
21Oxytocin signaling pathway_Homo sapiens_hsa049211.56905417
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56114995
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55421569
24Malaria_Homo sapiens_hsa051441.54368425
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51576723
26Insulin secretion_Homo sapiens_hsa049111.49463120
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48874912
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48706332
29Dopaminergic synapse_Homo sapiens_hsa047281.47833027
30Renin secretion_Homo sapiens_hsa049241.47741434
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47563417
32Cholinergic synapse_Homo sapiens_hsa047251.45912506
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44719028
34Amphetamine addiction_Homo sapiens_hsa050311.44586878
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42364894
36ECM-receptor interaction_Homo sapiens_hsa045121.38474887
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.31355055
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30750722
39Type II diabetes mellitus_Homo sapiens_hsa049301.30122242
40Calcium signaling pathway_Homo sapiens_hsa040201.29946164
41Adherens junction_Homo sapiens_hsa045201.29265129
42GnRH signaling pathway_Homo sapiens_hsa049121.22362091
43cAMP signaling pathway_Homo sapiens_hsa040241.21544486
44Glioma_Homo sapiens_hsa052141.19775830
45mTOR signaling pathway_Homo sapiens_hsa041501.19771021
46Prostate cancer_Homo sapiens_hsa052151.19520472
47Small cell lung cancer_Homo sapiens_hsa052221.19501757
48FoxO signaling pathway_Homo sapiens_hsa040681.17525430
49Circadian rhythm_Homo sapiens_hsa047101.15925891
50Amoebiasis_Homo sapiens_hsa051461.12665129
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12135328
52Gap junction_Homo sapiens_hsa045401.10845496
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.10727444
54Dorso-ventral axis formation_Homo sapiens_hsa043201.10630563
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10309225
56Osteoclast differentiation_Homo sapiens_hsa043801.10297267
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08556805
58B cell receptor signaling pathway_Homo sapiens_hsa046621.08455651
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06952146
60Acute myeloid leukemia_Homo sapiens_hsa052211.05806400
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02653273
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00574139
63Prolactin signaling pathway_Homo sapiens_hsa049170.99463842
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.98347167
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97695670
66Taste transduction_Homo sapiens_hsa047420.97131437
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.96172098
68Estrogen signaling pathway_Homo sapiens_hsa049150.93075547
69Cocaine addiction_Homo sapiens_hsa050300.91948337
70Long-term depression_Homo sapiens_hsa047300.91900497
71Non-small cell lung cancer_Homo sapiens_hsa052230.90962137
72Melanoma_Homo sapiens_hsa052180.90300186
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90169402
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.89491599
75Thyroid cancer_Homo sapiens_hsa052160.87959788
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87739515
77Glucagon signaling pathway_Homo sapiens_hsa049220.87482128
78VEGF signaling pathway_Homo sapiens_hsa043700.86063647
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84463920
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81874874
81Insulin signaling pathway_Homo sapiens_hsa049100.81713316
82MicroRNAs in cancer_Homo sapiens_hsa052060.81161812
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.80574098
84Bile secretion_Homo sapiens_hsa049760.80149197
85Insulin resistance_Homo sapiens_hsa049310.80020961
86T cell receptor signaling pathway_Homo sapiens_hsa046600.77275346
87Hepatitis B_Homo sapiens_hsa051610.76263644
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75976738
89Serotonergic synapse_Homo sapiens_hsa047260.75042597
90Phototransduction_Homo sapiens_hsa047440.74879248
91Choline metabolism in cancer_Homo sapiens_hsa052310.74419933
92Hepatitis C_Homo sapiens_hsa051600.73916322
93AMPK signaling pathway_Homo sapiens_hsa041520.73810309
94ErbB signaling pathway_Homo sapiens_hsa040120.73362587
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.72339450
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71096656
97Alcoholism_Homo sapiens_hsa050340.70607320
98Inositol phosphate metabolism_Homo sapiens_hsa005620.69074863
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.68480868
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.68271728
101Chemokine signaling pathway_Homo sapiens_hsa040620.67864403
102Renal cell carcinoma_Homo sapiens_hsa052110.67018058
103Lysosome_Homo sapiens_hsa041420.66721073
104Colorectal cancer_Homo sapiens_hsa052100.66126506
105MAPK signaling pathway_Homo sapiens_hsa040100.65392275
106Pancreatic secretion_Homo sapiens_hsa049720.65017455
107Rap1 signaling pathway_Homo sapiens_hsa040150.64730449
108Carbon metabolism_Homo sapiens_hsa012000.64151844
109Endometrial cancer_Homo sapiens_hsa052130.64115053
110Toxoplasmosis_Homo sapiens_hsa051450.63740524
111ABC transporters_Homo sapiens_hsa020100.63583823
112Melanogenesis_Homo sapiens_hsa049160.63547022
113Bladder cancer_Homo sapiens_hsa052190.62737580
114Thyroid hormone synthesis_Homo sapiens_hsa049180.61903900
115Focal adhesion_Homo sapiens_hsa045100.61018705
116TNF signaling pathway_Homo sapiens_hsa046680.60089721
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59451016
118Arginine biosynthesis_Homo sapiens_hsa002200.58622759
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58471276
120Oocyte meiosis_Homo sapiens_hsa041140.56525541
121African trypanosomiasis_Homo sapiens_hsa051430.56234873
122HIF-1 signaling pathway_Homo sapiens_hsa040660.55645690
123Ras signaling pathway_Homo sapiens_hsa040140.54741216
124Measles_Homo sapiens_hsa051620.54366653
125Endocytosis_Homo sapiens_hsa041440.54042199
126Propanoate metabolism_Homo sapiens_hsa006400.53830955
127Collecting duct acid secretion_Homo sapiens_hsa049660.53247505
128Pathways in cancer_Homo sapiens_hsa052000.52928134
129Apoptosis_Homo sapiens_hsa042100.52619049
130Platelet activation_Homo sapiens_hsa046110.51921535
131Prion diseases_Homo sapiens_hsa050200.51458831
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51241185
133Vitamin B6 metabolism_Homo sapiens_hsa007500.50877799
134Axon guidance_Homo sapiens_hsa043600.50285747
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49615644
136Proteoglycans in cancer_Homo sapiens_hsa052050.48166184
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47975513
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47239941
139Tight junction_Homo sapiens_hsa045300.47214467
140Butanoate metabolism_Homo sapiens_hsa006500.46448309
141Fatty acid degradation_Homo sapiens_hsa000710.45320839
142Chronic myeloid leukemia_Homo sapiens_hsa052200.45219792
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43623758
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43411702

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