TRAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.46200096
2COPI coating of Golgi vesicle (GO:0048205)8.46200096
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.95161324
4signal peptide processing (GO:0006465)6.86509243
5protein retention in ER lumen (GO:0006621)6.28452421
6COPII vesicle coating (GO:0048208)5.90568037
7sequestering of metal ion (GO:0051238)4.70147049
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.50411981
9cell adhesion mediated by integrin (GO:0033627)4.44790755
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.38302480
11positive regulation of nuclease activity (GO:0032075)4.28336069
12exocrine pancreas development (GO:0031017)4.15770273
13endocrine pancreas development (GO:0031018)4.11121941
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02405868
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.02405868
16protein maturation by protein folding (GO:0022417)4.00833441
17regulation of nuclease activity (GO:0032069)3.98322402
18endoplasmic reticulum unfolded protein response (GO:0030968)3.96390178
19cellular response to unfolded protein (GO:0034620)3.93635041
20ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.87460959
21skin morphogenesis (GO:0043589)3.75135212
22cellular response to topologically incorrect protein (GO:0035967)3.75006995
23positive regulation of endothelial cell apoptotic process (GO:2000353)3.74887639
24UDP-N-acetylglucosamine metabolic process (GO:0006047)3.72100474
25vesicle coating (GO:0006901)3.70084628
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67809822
27ER-nucleus signaling pathway (GO:0006984)3.66920023
28protein N-linked glycosylation via asparagine (GO:0018279)3.64164244
29protein localization to endosome (GO:0036010)3.62347733
30peptidyl-asparagine modification (GO:0018196)3.59837164
31intestinal cholesterol absorption (GO:0030299)3.56287686
32membrane raft organization (GO:0031579)3.51741792
33regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.47819182
34ER overload response (GO:0006983)3.47352694
35hemidesmosome assembly (GO:0031581)3.46590778
36antigen processing and presentation of endogenous antigen (GO:0019883)3.45583743
37endodermal cell differentiation (GO:0035987)3.38683427
38peptide catabolic process (GO:0043171)3.37984215
39pinocytosis (GO:0006907)3.34096936
40protein N-linked glycosylation (GO:0006487)3.32874218
41regulation of glucokinase activity (GO:0033131)3.32223074
42regulation of hexokinase activity (GO:1903299)3.32223074
43peptide hormone processing (GO:0016486)3.31864721
44peptidyl-proline hydroxylation (GO:0019511)3.28946483
45protein hydroxylation (GO:0018126)3.25405241
46response to endoplasmic reticulum stress (GO:0034976)3.24203880
47hypotonic response (GO:0006971)3.22788258
48type B pancreatic cell proliferation (GO:0044342)3.15695611
49ER to Golgi vesicle-mediated transport (GO:0006888)3.13945542
50valine metabolic process (GO:0006573)3.12794426
51positive regulation of extracellular matrix organization (GO:1903055)3.10591996
52collagen fibril organization (GO:0030199)3.08645469
53regulation of metalloenzyme activity (GO:0048552)3.07964962
54hyaluronan catabolic process (GO:0030214)3.06925891
55regulation of transforming growth factor beta1 production (GO:0032908)3.06508798
56type B pancreatic cell development (GO:0003323)3.05647345
57apoptotic cell clearance (GO:0043277)3.03567821
58negative regulation of bone resorption (GO:0045779)3.01478327
59surfactant homeostasis (GO:0043129)3.00660105
60negative regulation of protein localization to plasma membrane (GO:1903077)2.95919071
61positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.93391903
62embryonic process involved in female pregnancy (GO:0060136)2.92755713
63response to unfolded protein (GO:0006986)2.91048073
64regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88334332
65glandular epithelial cell differentiation (GO:0002067)2.83176419
66cell-substrate junction assembly (GO:0007044)2.80658780
67response to topologically incorrect protein (GO:0035966)2.80394322
684-hydroxyproline metabolic process (GO:0019471)2.76089035
69regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.74190375
70extracellular fibril organization (GO:0043206)2.73288009
71cellular response to vitamin (GO:0071295)2.71822122
72membrane protein ectodomain proteolysis (GO:0006509)2.71816370
73proline biosynthetic process (GO:0006561)2.70254398
74fibril organization (GO:0097435)2.69390978
75mesodermal cell differentiation (GO:0048333)2.66809039
76sequestering of extracellular ligand from receptor (GO:0035581)2.66614661
77barbed-end actin filament capping (GO:0051016)2.65533198
78glandular epithelial cell development (GO:0002068)2.65275948
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64719952
80platelet degranulation (GO:0002576)2.62759329
81regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.62643933
82negative regulation of phagocytosis (GO:0050765)2.62083791
83basement membrane organization (GO:0071711)2.61496824
84wound healing, spreading of epidermal cells (GO:0035313)2.60131170
85fibrinolysis (GO:0042730)2.59529118
86negative regulation of fibrinolysis (GO:0051918)2.59276121
87L-phenylalanine catabolic process (GO:0006559)2.58889960
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.58889960
89nucleotide-sugar biosynthetic process (GO:0009226)2.58718917
90stress fiber assembly (GO:0043149)2.58364679
91regulation of transforming growth factor beta2 production (GO:0032909)2.58000947
92positive regulation of osteoblast proliferation (GO:0033690)2.57547612
93regulation of type B pancreatic cell apoptotic process (GO:2000674)2.56740373
94interleukin-1-mediated signaling pathway (GO:0070498)2.53990041
95folic acid-containing compound biosynthetic process (GO:0009396)2.52769039
96nucleotide-sugar metabolic process (GO:0009225)2.52155496
97pteridine-containing compound biosynthetic process (GO:0042559)2.51498756
98regulation of extracellular matrix disassembly (GO:0010715)2.51495897
99desmosome organization (GO:0002934)2.51265358
100intestinal absorption (GO:0050892)2.50808349
101cellular zinc ion homeostasis (GO:0006882)2.50400745
102antigen processing and presentation via MHC class Ib (GO:0002475)2.47177088
103collagen metabolic process (GO:0032963)2.46429135
104cell redox homeostasis (GO:0045454)2.46249153
105positive regulation of hemostasis (GO:1900048)2.45951582
106positive regulation of blood coagulation (GO:0030194)2.45951582
107Arp2/3 complex-mediated actin nucleation (GO:0034314)2.44767180
108production of molecular mediator involved in inflammatory response (GO:0002532)2.43870077
109negative regulation of glycoprotein biosynthetic process (GO:0010561)2.43862386
110negative regulation of fatty acid transport (GO:2000192)2.43363173
111GDP-mannose metabolic process (GO:0019673)2.40837108
112regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.40572270
113regulation of plasminogen activation (GO:0010755)2.40243285
114protein autoprocessing (GO:0016540)2.38862830
115extracellular matrix disassembly (GO:0022617)2.38579993
116positive regulation of insulin secretion (GO:0032024)2.38016902
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37417804
118L-phenylalanine metabolic process (GO:0006558)2.37417804
119multicellular organismal macromolecule metabolic process (GO:0044259)2.36875160
120positive regulation of receptor recycling (GO:0001921)2.36098931
121polyketide metabolic process (GO:0030638)2.35213573
122doxorubicin metabolic process (GO:0044598)2.35213573
123daunorubicin metabolic process (GO:0044597)2.35213573
124regulation of endothelial cell apoptotic process (GO:2000351)2.35199925
125positive regulation of coagulation (GO:0050820)2.34958855
126regulation of early endosome to late endosome transport (GO:2000641)2.34380647
127regulation of integrin-mediated signaling pathway (GO:2001044)2.33781669
128positive regulation of macrophage differentiation (GO:0045651)2.33578230
129mitochondrial calcium ion transport (GO:0006851)2.32762173
130negative regulation of bone remodeling (GO:0046851)2.32671012
131negative regulation of smooth muscle cell migration (GO:0014912)2.32140273
132chondrocyte development (GO:0002063)2.31400181
133retina vasculature morphogenesis in camera-type eye (GO:0061299)2.30634478
134Golgi organization (GO:0007030)2.29985135
135multicellular organismal metabolic process (GO:0044236)2.29686435
136response to laminar fluid shear stress (GO:0034616)2.28955044
137collagen catabolic process (GO:0030574)2.28758839
138negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.28543476
139zinc ion homeostasis (GO:0055069)2.28111211
140negative regulation of protein activation cascade (GO:2000258)2.27701079
141blood vessel maturation (GO:0001955)2.27475199
142negative regulation of complement activation (GO:0045916)2.26579361
143columnar/cuboidal epithelial cell development (GO:0002066)2.25740256
144maintenance of protein localization in organelle (GO:0072595)2.25129481
145epithelial cell-cell adhesion (GO:0090136)2.24683719
146positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23784496
147regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.23157330
148L-alpha-amino acid transmembrane transport (GO:1902475)2.22473510
149intra-Golgi vesicle-mediated transport (GO:0006891)2.22033085
150wound healing, spreading of cells (GO:0044319)2.21981039
151extracellular matrix assembly (GO:0085029)2.21671767
152multicellular organismal catabolic process (GO:0044243)2.21599448
153regulation of transforming growth factor beta production (GO:0071634)2.21040075
154positive regulation of blood vessel endothelial cell migration (GO:0043536)2.20628817
155hepatocyte apoptotic process (GO:0097284)2.19688875
156regulation of integrin activation (GO:0033623)2.19627760
157tetrahydrofolate metabolic process (GO:0046653)2.19616517
158platelet aggregation (GO:0070527)2.18788447
159iron ion import (GO:0097286)2.18721977
160reactive oxygen species biosynthetic process (GO:1903409)2.18224593
161protein carboxylation (GO:0018214)2.18069961
162peptidyl-glutamic acid carboxylation (GO:0017187)2.18069961
163transcytosis (GO:0045056)2.15309096
164cellular response to antibiotic (GO:0071236)2.12708666
165purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.12556198
1663-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.12556198
167hormone catabolic process (GO:0042447)2.12517906
168aromatic amino acid family catabolic process (GO:0009074)2.12370583
169cellular response to vitamin D (GO:0071305)2.09913866
170positive regulation of gamma-delta T cell activation (GO:0046645)2.09661199
171regulation of apoptotic cell clearance (GO:2000425)2.08114014
172hydrogen peroxide biosynthetic process (GO:0050665)2.05983836
173keratan sulfate catabolic process (GO:0042340)2.05004374
174dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.03373579
175negative regulation of tissue remodeling (GO:0034104)2.02548678
176peptide metabolic process (GO:0006518)2.01641556
177digestion (GO:0007586)2.00377154
178sulfur amino acid catabolic process (GO:0000098)1.99614683
179post-translational protein modification (GO:0043687)1.98659115
180positive regulation of glycolytic process (GO:0045821)1.98592662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.73104008
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.40815582
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.06470295
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.58099567
5GATA1_22025678_ChIP-Seq_K562_Human3.23567047
6E2F7_22180533_ChIP-Seq_HELA_Human3.15336084
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.06702360
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.06324306
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.04359812
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.88642659
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.71817388
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59369262
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55813747
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.48760788
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42291682
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.40603675
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.33891933
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22588573
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.21820557
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.21769482
21* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.21769482
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.20284411
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17906641
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.16278941
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14475946
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07525242
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.03348970
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.03319381
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.01310489
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00872235
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.99152081
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.97971118
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.97789045
34BRD4_25478319_ChIP-Seq_HGPS_Human1.93724437
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93438054
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.93349291
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.91683898
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.91460681
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82835909
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.80689479
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.79730404
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78493252
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77135869
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77129227
45CJUN_26792858_Chip-Seq_BT549_Human1.75607380
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75134054
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74057530
48* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73739708
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70870273
50AR_21909140_ChIP-Seq_LNCAP_Human1.70076142
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.70033048
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69679945
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68153044
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66414477
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65886441
56ELK1_19687146_ChIP-ChIP_HELA_Human1.63253014
57SOX2_20726797_ChIP-Seq_SW620_Human1.62367050
58* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61604908
59MYB_26560356_Chip-Seq_TH2_Human1.60857079
60TFEB_21752829_ChIP-Seq_HELA_Human1.60543529
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.60432727
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59862753
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57774468
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56465113
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55335285
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.54264844
67* SPI1_23547873_ChIP-Seq_NB4_Human1.52973260
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52699916
69ZNF263_19887448_ChIP-Seq_K562_Human1.50484981
70MYB_26560356_Chip-Seq_TH1_Human1.50053563
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.49720257
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49576414
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.46681136
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46025504
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46025504
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45057702
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44392270
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.44191973
79* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44003620
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42992670
81* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41689427
82* VDR_23849224_ChIP-Seq_CD4+_Human1.41326971
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41081252
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39200851
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38630898
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.37538056
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37071278
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36478938
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.34943225
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34932649
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.34267947
92SCL_19346495_ChIP-Seq_HPC-7_Human1.33999056
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33444920
94MYC_22102868_ChIP-Seq_BL_Human1.29043713
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28316239
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26434642
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26098936
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.25893646
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24963465
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23116379
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22406325
102ATF3_27146783_Chip-Seq_COLON_Human1.21615148
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21462345
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.21255664
105* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18849579
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18564428
107* GATA3_27048872_Chip-Seq_THYMUS_Human1.15954385
108FOXP3_21729870_ChIP-Seq_TREG_Human1.14800948
109EST1_17652178_ChIP-ChIP_JURKAT_Human1.14315637
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14210377
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13931772
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12697494
113FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11987753
114RUNX1_22412390_ChIP-Seq_EML_Mouse1.11389021
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10765864
116JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10609281
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10187079
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10034628
119FOXM1_23109430_ChIP-Seq_U2OS_Human1.09942785
120TBX20_22328084_ChIP-Seq_HEART_Mouse1.09702274
121TBX20_22080862_ChIP-Seq_HEART_Mouse1.09702274
122GATA3_26560356_Chip-Seq_TH2_Human1.09461440
123GATA4_25053715_ChIP-Seq_YYC3_Human1.09405035
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09222268
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09023971
126EP300_21415370_ChIP-Seq_HL-1_Mouse1.08112313
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08031247
128RUNX_20019798_ChIP-Seq_JUKART_Human1.08005487
129EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07338329
130* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06241342
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06226164
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05646411
133* PU_27001747_Chip-Seq_BMDM_Mouse1.05124252
134CLOCK_20551151_ChIP-Seq_293T_Human1.04824428
135NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04739185
136NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04560107
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04083600
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03997620
139* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03048063
140P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02641681
141TP53_18474530_ChIP-ChIP_U2OS_Human1.02059142
142GATA6_25053715_ChIP-Seq_YYC3_Human1.00553323
143E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97764567
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96468954
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.94953131
146CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94178736
147VDR_24763502_ChIP-Seq_THP-1_Human0.93900486
148* GABP_19822575_ChIP-Seq_HepG2_Human0.93892723
149DCP1A_22483619_ChIP-Seq_HELA_Human0.93382211
150TP63_23658742_ChIP-Seq_EP156T_Human0.93096923
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92896067
152E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92675889
153PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.92343416
154KDM5A_27292631_Chip-Seq_BREAST_Human0.91855588
155E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91490724
156* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91416817
157FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90745725
158FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90509737
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89544548
160TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88432854
161GATA3_24758297_ChIP-Seq_MCF-7_Human0.88394310
162* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88357460
163MYC_18555785_ChIP-Seq_MESCs_Mouse0.87966548
164MAF_26560356_Chip-Seq_TH1_Human0.87823552
165FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87211959
166PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85543828
167RACK7_27058665_Chip-Seq_MCF-7_Human0.85246414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.73234679
2MP0004272_abnormal_basement_membrane3.38529222
3MP0003705_abnormal_hypodermis_morpholog2.91406682
4MP0005275_abnormal_skin_tensile2.91115299
5MP0005365_abnormal_bile_salt2.89539506
6MP0003566_abnormal_cell_adhesion2.88853617
7MP0002139_abnormal_hepatobiliary_system2.80991358
8MP0005220_abnormal_exocrine_pancreas2.57719368
9MP0006054_spinal_hemorrhage2.54750723
10MP0002693_abnormal_pancreas_physiology2.51925330
11MP0003195_calcinosis2.46698815
12MP0001958_emphysema2.46206620
13MP0003279_aneurysm2.27565144
14MP0005085_abnormal_gallbladder_physiolo2.18568287
15MP0001666_abnormal_nutrient_absorption2.11696726
16MP0005023_abnormal_wound_healing2.08217242
17MP0005503_abnormal_tendon_morphology2.03718578
18MP0003091_abnormal_cell_migration2.02565177
19MP0001944_abnormal_pancreas_morphology2.02380408
20MP0004264_abnormal_extraembryonic_tissu2.00889145
21MP0003183_abnormal_peptide_metabolism1.97862346
22MP0005257_abnormal_intraocular_pressure1.96818941
23MP0003950_abnormal_plasma_membrane1.93580088
24MP0010386_abnormal_urinary_bladder1.87683598
25MP0001835_abnormal_antigen_presentation1.86568795
26MP0003252_abnormal_bile_duct1.85437254
27MP0003300_gastrointestinal_ulcer1.81051493
28MP0003868_abnormal_feces_composition1.74268519
29MP0002138_abnormal_hepatobiliary_system1.69233636
30MP0005058_abnormal_lysosome_morphology1.66149694
31MP0002166_altered_tumor_susceptibility1.62930814
32MP0005083_abnormal_biliary_tract1.62352712
33MP0005623_abnormal_meninges_morphology1.59518167
34MP0003436_decreased_susceptibility_to1.58843867
35MP0001542_abnormal_bone_strength1.55251446
36MP0010368_abnormal_lymphatic_system1.53291029
37MP0005360_urolithiasis1.52052634
38MP0003941_abnormal_skin_development1.47185983
39MP0002928_abnormal_bile_duct1.45298989
40MP0005164_abnormal_response_to1.44735667
41MP0003693_abnormal_embryo_hatching1.44545491
42MP0005379_endocrine/exocrine_gland_phen1.41166887
43MP0004043_abnormal_pH_regulation1.37991600
44MP0009643_abnormal_urine_homeostasis1.36521734
45MP0004782_abnormal_surfactant_physiolog1.36402494
46MP0003724_increased_susceptibility_to1.31295412
47MP0000465_gastrointestinal_hemorrhage1.31078309
48MP0003448_altered_tumor_morphology1.30029268
49MP0005084_abnormal_gallbladder_morpholo1.28630955
50MP0005671_abnormal_response_to1.28049301
51MP0008004_abnormal_stomach_pH1.27295687
52MP0005408_hypopigmentation1.26092964
53MP0002078_abnormal_glucose_homeostasis1.25860999
54MP0002006_tumorigenesis1.25007414
55MP0000767_abnormal_smooth_muscle1.23106853
56MP0003186_abnormal_redox_activity1.22692030
57MP0002009_preneoplasia1.21287549
58MP0010234_abnormal_vibrissa_follicle1.19927372
59MP0010352_gastrointestinal_tract_polyps1.19804926
60MP0003763_abnormal_thymus_physiology1.19665585
61MP0000013_abnormal_adipose_tissue1.19648519
62MP0005000_abnormal_immune_tolerance1.18981286
63MP0001845_abnormal_inflammatory_respons1.18335817
64MP0003828_pulmonary_edema1.18101613
65MP0003806_abnormal_nucleotide_metabolis1.18023803
66MP0001243_abnormal_dermal_layer1.17809395
67MP0005464_abnormal_platelet_physiology1.17290504
68MP0005387_immune_system_phenotype1.16411576
69MP0001790_abnormal_immune_system1.16411576
70MP0009780_abnormal_chondrocyte_physiolo1.15795962
71MP0000609_abnormal_liver_physiology1.13792588
72MP0000678_abnormal_parathyroid_gland1.13597048
73MP0002396_abnormal_hematopoietic_system1.12790708
74MP0009785_altered_susceptibility_to1.12615246
75MP0002419_abnormal_innate_immunity1.12410463
76MP0005310_abnormal_salivary_gland1.12331181
77MP0002998_abnormal_bone_remodeling1.12049235
78MP0003453_abnormal_keratinocyte_physiol1.11247114
79MP0001764_abnormal_homeostasis1.10245300
80MP0001915_intracranial_hemorrhage1.09254702
81MP0000490_abnormal_crypts_of1.08799067
82MP0005165_increased_susceptibility_to1.08450763
83MP0009384_cardiac_valve_regurgitation1.08154275
84MP0006082_CNS_inflammation1.06093278
85MP0001851_eye_inflammation1.05273770
86MP0005025_abnormal_response_to1.05242281
87MP0001533_abnormal_skeleton_physiology1.05198368
88MP0008469_abnormal_protein_level1.04780433
89MP0001800_abnormal_humoral_immune1.04172591
90MP0004883_abnormal_blood_vessel1.02773871
91MP0003172_abnormal_lysosome_physiology1.02345512
92MP0002909_abnormal_adrenal_gland1.01892065
93MP0002148_abnormal_hypersensitivity_rea1.01717658
94MP0002452_abnormal_antigen_presenting1.00497544
95MP0000613_abnormal_salivary_gland0.99038380
96MP0004947_skin_inflammation0.98629090
97MP0008260_abnormal_autophagy0.98341447
98MP0000685_abnormal_immune_system0.98223168
99MP0010155_abnormal_intestine_physiology0.98214823
100MP0002723_abnormal_immune_serum0.98127748
101MP0002420_abnormal_adaptive_immunity0.97981529
102MP0003191_abnormal_cellular_cholesterol0.97653370
103MP0005508_abnormal_skeleton_morphology0.97314160
104MP0001819_abnormal_immune_cell0.95737840
105MP0001849_ear_inflammation0.94969521
106MP0005390_skeleton_phenotype0.94414188
107MP0005319_abnormal_enzyme/_coenzyme0.94168067
108MP0002295_abnormal_pulmonary_circulatio0.94023841
109MP0003795_abnormal_bone_structure0.93620352
110MP0005636_abnormal_mineral_homeostasis0.93504723
111MP0008875_abnormal_xenobiotic_pharmacok0.92885992
112MP0010329_abnormal_lipoprotein_level0.92580728
113MP0000598_abnormal_liver_morphology0.91833803
114MP0001879_abnormal_lymphatic_vessel0.91659827
115MP0002896_abnormal_bone_mineralization0.91599316
116MP0000343_altered_response_to0.91302304
117MP0000249_abnormal_blood_vessel0.90858357
118MP0000858_altered_metastatic_potential0.89278013
119MP0001873_stomach_inflammation0.88963092
120MP0002796_impaired_skin_barrier0.86138865
121MP0003943_abnormal_hepatobiliary_system0.85546617
122MP0008438_abnormal_cutaneous_collagen0.85442925
123MP0002398_abnormal_bone_marrow0.85009459
124MP0008007_abnormal_cellular_replicative0.84828737
125MP0002060_abnormal_skin_morphology0.84688980
126MP0002405_respiratory_system_inflammati0.84611284
127MP0001216_abnormal_epidermal_layer0.84210148
128MP0001756_abnormal_urination0.84182405
129MP0002933_joint_inflammation0.83613842
130MP0001661_extended_life_span0.81844728
131MP0002118_abnormal_lipid_homeostasis0.80639913
132MP0002876_abnormal_thyroid_physiology0.80057310
133MP0005076_abnormal_cell_differentiation0.79821113
134MP0005621_abnormal_cell_physiology0.79539535
135MP0005332_abnormal_amino_acid0.79415918
136MP0000371_diluted_coat_color0.79362216
137MP0000716_abnormal_immune_system0.79091420
138MP0005451_abnormal_body_composition0.78499238
139MP0010307_abnormal_tumor_latency0.77486768
140MP0009840_abnormal_foam_cell0.77140456
141MP0004808_abnormal_hematopoietic_stem0.76866536
142MP0000689_abnormal_spleen_morphology0.76577307
143MP0003866_abnormal_defecation0.75334924
144MP0001348_abnormal_lacrimal_gland0.71916205
145MP0005388_respiratory_system_phenotype0.71873843
146MP0002133_abnormal_respiratory_system0.71873843
147MP0009053_abnormal_anal_canal0.71855742
148MP0002128_abnormal_blood_circulation0.71744692
149MP0001881_abnormal_mammary_gland0.71515934
150MP0005197_abnormal_uvea_morphology0.71346673
151MP0001853_heart_inflammation0.70429449
152MP0000762_abnormal_tongue_morphology0.69861641
153MP0001614_abnormal_blood_vessel0.69802989
154MP0009333_abnormal_splenocyte_physiolog0.69074980
155MP0005501_abnormal_skin_physiology0.68477919
156MP0000627_abnormal_mammary_gland0.67002108
157MP0000604_amyloidosis0.66485040

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.77150139
2Protrusio acetabuli (HP:0003179)5.40066002
3Hypoglycemic seizures (HP:0002173)4.59922334
4Hypoglycemic coma (HP:0001325)4.58776922
5Aortic dissection (HP:0002647)4.58612982
6Vascular tortuosity (HP:0004948)4.55485075
7Arterial tortuosity (HP:0005116)4.42803044
8Hyperinsulinemic hypoglycemia (HP:0000825)4.29922395
9Symptomatic seizures (HP:0011145)4.16557907
10Abnormality of the intrinsic pathway (HP:0010989)4.15695450
11Aortic aneurysm (HP:0004942)4.06599992
12Atrophic scars (HP:0001075)3.54331056
13Vertebral compression fractures (HP:0002953)3.49521086
14Osteolytic defects of the hand bones (HP:0009699)3.43813953
15Osteolytic defects of the phalanges of the hand (HP:0009771)3.43813953
16Abnormality of the pancreatic islet cells (HP:0006476)3.40575776
17Abnormality of endocrine pancreas physiology (HP:0012093)3.40575776
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.33096809
19Pancreatic islet-cell hyperplasia (HP:0004510)3.26030230
20Abnormality of the common coagulation pathway (HP:0010990)3.24573688
21Conjugated hyperbilirubinemia (HP:0002908)3.22567705
22Urinary glycosaminoglycan excretion (HP:0003541)3.20577545
23Mucopolysacchariduria (HP:0008155)3.20577545
24Ankle contracture (HP:0006466)3.18949555
25Hyperglycemia (HP:0003074)3.17887257
26Vacuolated lymphocytes (HP:0001922)3.17444628
27Generalized aminoaciduria (HP:0002909)3.12119766
28Wormian bones (HP:0002645)3.09915085
29Dilatation of the ascending aorta (HP:0005111)3.08031360
30Dysostosis multiplex (HP:0000943)2.94337906
31Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93846234
32Abnormality of polysaccharide metabolism (HP:0011012)2.93846234
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93846234
34Soft skin (HP:0000977)2.88164062
35Insulin-resistant diabetes mellitus (HP:0000831)2.86980383
36Intrahepatic cholestasis (HP:0001406)2.84179509
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.83442887
38Abnormal protein N-linked glycosylation (HP:0012347)2.83442887
39Abnormal protein glycosylation (HP:0012346)2.83442887
40Abnormal glycosylation (HP:0012345)2.83442887
41Fat malabsorption (HP:0002630)2.82461010
42Blue sclerae (HP:0000592)2.77343079
43Mitral stenosis (HP:0001718)2.75954560
44Increased mean platelet volume (HP:0011877)2.75942626
45Fragile skin (HP:0001030)2.75160454
46Limb hypertonia (HP:0002509)2.72470644
47Follicular hyperkeratosis (HP:0007502)2.70137379
48Abnormal foot bone ossification (HP:0010675)2.69749182
49Abnormality of T cell physiology (HP:0011840)2.69423583
50Thoracolumbar scoliosis (HP:0002944)2.58697808
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56992741
52Reduced antithrombin III activity (HP:0001976)2.56811114
53Peritonitis (HP:0002586)2.55097745
54Bladder diverticulum (HP:0000015)2.54261442
55Abnormal platelet volume (HP:0011876)2.53013098
56Type I transferrin isoform profile (HP:0003642)2.52326507
57Ketoacidosis (HP:0001993)2.48151043
58Mitral valve prolapse (HP:0001634)2.39544821
59Late onset (HP:0003584)2.38427492
60Steatorrhea (HP:0002570)2.36448266
61Prolonged partial thromboplastin time (HP:0003645)2.36342996
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.35728855
63Beaking of vertebral bodies (HP:0004568)2.34069073
64Abnormality of the acetabulum (HP:0003170)2.33716679
65Hypoplasia of the thymus (HP:0000778)2.32283934
66Tetraparesis (HP:0002273)2.30086232
67Aneurysm (HP:0002617)2.28641047
68Interstitial pulmonary disease (HP:0006530)2.28146821
69Spinal rigidity (HP:0003306)2.25450071
70Cardiovascular calcification (HP:0011915)2.25351596
71Cerebral aneurysm (HP:0004944)2.24204821
72Abnormality of dentin (HP:0010299)2.23039716
7311 pairs of ribs (HP:0000878)2.21444578
74Abnormal delivery (HP:0001787)2.19583989
75Abnormality of oral frenula (HP:0000190)2.16534712
76Abnormality of complement system (HP:0005339)2.16521342
77Abnormality of liposaccharide metabolism (HP:0010968)2.14501855
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.14501855
79Abnormality of glycolipid metabolism (HP:0010969)2.14501855
80Syringomyelia (HP:0003396)2.13553723
81Spinal cord lesions (HP:0100561)2.13553723
82Thrombocytosis (HP:0001894)2.13332036
83Abnormal pancreas size (HP:0012094)2.12828211
84Aplastic anemia (HP:0001915)2.12403032
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.10736628
86Elbow flexion contracture (HP:0002987)2.10660011
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10287247
88Recurrent abscess formation (HP:0002722)2.08964413
89Absent frontal sinuses (HP:0002688)2.07396514
90Insulin resistance (HP:0000855)2.07091218
91Hyperbilirubinemia (HP:0002904)2.03745585
92Abnormality of the anterior horn cell (HP:0006802)2.03083651
93Degeneration of anterior horn cells (HP:0002398)2.03083651
94Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02064464
95Cervical subluxation (HP:0003308)2.01828592
96Nonimmune hydrops fetalis (HP:0001790)2.01376143
97Joint hemorrhage (HP:0005261)2.00968183
98Abnormal tarsal ossification (HP:0008369)2.00620074
99Protuberant abdomen (HP:0001538)1.99489281
100Joint laxity (HP:0001388)1.99278954
101Renal cortical cysts (HP:0000803)1.99070622
102Flat acetabular roof (HP:0003180)1.99014719
103Abnormality of T cells (HP:0002843)1.98808514
104Short nail (HP:0001799)1.97728694
105IgM deficiency (HP:0002850)1.97256638
106Deep venous thrombosis (HP:0002625)1.96429391
107Aortic regurgitation (HP:0001659)1.96167300
108Exocrine pancreatic insufficiency (HP:0001738)1.95876614
109Recurrent bronchitis (HP:0002837)1.95330364
110Ankyloglossia (HP:0010296)1.93949848
111Ketosis (HP:0001946)1.93814875
112Abdominal distention (HP:0003270)1.93608866
113Neonatal short-limb short stature (HP:0008921)1.93304425
114Abnormal biliary tract morphology (HP:0012440)1.93219801
115Abnormality of skull ossification (HP:0002703)1.92440161
116Complement deficiency (HP:0004431)1.92134375
117Chondrocalcinosis (HP:0000934)1.90416180
118Delayed closure of the anterior fontanelle (HP:0001476)1.90315629
119Periodontitis (HP:0000704)1.89962904
120Gingival bleeding (HP:0000225)1.89261138
121Elevated alkaline phosphatase (HP:0003155)1.88839702
122Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.87528078
123Spondylolisthesis (HP:0003302)1.86556318
124Genu recurvatum (HP:0002816)1.85490524
125Recurrent viral infections (HP:0004429)1.84922604
126Ovoid vertebral bodies (HP:0003300)1.84793688
127Hyperextensible skin (HP:0000974)1.83932413
128Abnormality of carpal bone ossification (HP:0006257)1.83457632
129Systemic lupus erythematosus (HP:0002725)1.83245714
130Abnormality of purine metabolism (HP:0004352)1.82917385
131Abnormality of Sharpey fibers (HP:0100685)1.82656954
132Pancreatitis (HP:0001733)1.82488421
133Hepatocellular carcinoma (HP:0001402)1.81731851
134Abnormality of the distal phalanges of the toes (HP:0010182)1.80919104
135T lymphocytopenia (HP:0005403)1.80528044
136Irregular vertebral endplates (HP:0003301)1.80045138
137Recurrent gram-negative bacterial infections (HP:0005420)1.79753586
138Prominent metopic ridge (HP:0005487)1.78522219
139Abnormality of alkaline phosphatase activity (HP:0004379)1.78357707
140Coxa vara (HP:0002812)1.77959200
141Mitral regurgitation (HP:0001653)1.77844794
142Vascular calcification (HP:0004934)1.77617905
143Abnormal enzyme/coenzyme activity (HP:0012379)1.76992993
144Recurrent bacterial skin infections (HP:0005406)1.75940010
145Purpura (HP:0000979)1.74692879
146Epistaxis (HP:0000421)1.74211423
147Abnormality of T cell number (HP:0011839)1.73296583
148Back pain (HP:0003418)1.73230661
149Hydroxyprolinuria (HP:0003080)1.72948778
150Abnormality of proline metabolism (HP:0010907)1.72948778
151Barrel-shaped chest (HP:0001552)1.72229046
152Large for gestational age (HP:0001520)1.72053014
153Asymmetry of the thorax (HP:0001555)1.71575676
154Bronchitis (HP:0012387)1.71050187
155Decreased skull ossification (HP:0004331)1.70366480
156Glucose intolerance (HP:0000833)1.69971500
157Polycythemia (HP:0001901)1.69686765
158Increased variability in muscle fiber diameter (HP:0003557)1.69427228
159Hypochromic microcytic anemia (HP:0004840)1.68228898
160Coxa valga (HP:0002673)1.67865171
161Decreased circulating renin level (HP:0003351)1.67441528
162Menorrhagia (HP:0000132)1.66922862
163Impaired platelet aggregation (HP:0003540)1.65948254
164Abnormal platelet function (HP:0011869)1.65948254
165Eczematoid dermatitis (HP:0000976)1.64998893
166Biconcave vertebral bodies (HP:0004586)1.64744220
167Abnormality of skeletal muscle fiber size (HP:0012084)1.64124810
168Abnormal ossification of hand bones (HP:0005921)1.63902863
169Progressive neurologic deterioration (HP:0002344)1.63742167
170Severe short stature (HP:0003510)1.63643452
171Cupped ribs (HP:0000887)1.61844604
172Joint stiffness (HP:0001387)1.61490549
173Coarse hair (HP:0002208)1.60582559
174Broad face (HP:0000283)1.60387625
175Delayed cranial suture closure (HP:0000270)1.60168939
176Subacute progressive viral hepatitis (HP:0006572)1.59806256
177Xanthomatosis (HP:0000991)1.58470918
178Metaphyseal cupping (HP:0003021)1.57566173
179Myocardial infarction (HP:0001658)1.57068784
180Abnormality of subcutaneous fat tissue (HP:0001001)1.56516242
181Micronodular cirrhosis (HP:0001413)1.55277019
182Metaphyseal irregularity (HP:0003025)1.54797362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.87438143
2FRK3.80085302
3TAOK33.47820333
4MYLK3.29782811
5PASK3.22664645
6MST1R2.93416351
7ERN12.87046282
8IRAK32.77476352
9FLT32.72625394
10BRSK22.60373890
11BCKDK2.20069496
12EIF2AK32.13313894
13MET2.12762672
14IRAK42.11530368
15MAP3K142.08906010
16PAK41.99361217
17JAK31.89749786
18TTN1.83928976
19TEC1.78846448
20MAPK151.71663656
21MAP3K121.66655920
22PTK21.59242535
23SCYL21.58187379
24DDR21.58063221
25PIK3CG1.52518722
26RIPK11.52135623
27NUAK11.47455932
28ZAP701.44601890
29ZAK1.43842825
30LATS21.43025155
31PRPF4B1.42724527
32BTK1.40886549
33HIPK21.38811829
34PAK21.38723137
35MAP4K11.32835585
36ERBB41.32364279
37LATS11.32016714
38TYK21.31270851
39NEK91.29552952
40EPHB11.23208911
41ITK1.22867341
42PDGFRB1.20075331
43CDK61.18450383
44MAP3K31.17791696
45RPS6KA41.16475781
46LIMK11.16354456
47SIK31.13616562
48PTK61.12028095
49IRAK11.07764640
50NTRK11.06419057
51CDK121.04538832
52TXK1.00556526
53JAK10.98598013
54TBK10.97787440
55BMX0.97363955
56FER0.96220720
57EPHA30.95922522
58CHUK0.95400765
59ERBB30.95173027
60KIT0.91598459
61FGFR30.91341564
62MAP2K30.90721292
63IKBKE0.89348400
64STK100.89302752
65TIE10.89148336
66PIM10.87905436
67PRKD30.87052905
68NME20.86914680
69MAPKAPK30.85649644
70SIK10.84396686
71PKN20.83788122
72NLK0.83617229
73MOS0.83554651
74LMTK20.81786583
75FGFR40.81727462
76ILK0.81377223
77STK30.81071943
78MAP3K20.80729725
79ACVR1B0.78798868
80MST40.77598831
81MAP3K130.76506843
82CSK0.76234468
83ARAF0.75755139
84EIF2AK10.75170819
85TRPM70.71752124
86BRSK10.71660820
87TESK10.71433140
88BCR0.69812494
89MELK0.66789399
90DYRK1B0.65115802
91VRK10.64930048
92JAK20.64180031
93GRK70.63273995
94AKT30.63161589
95MARK30.60534341
96STK380.59522323
97ABL20.59341654
98EPHB20.58803275
99RPS6KB10.58731532
100RPS6KB20.58379012
101SYK0.57878115
102MAP2K20.57815419
103GRK60.57801119
104IKBKB0.57515994
105MAPKAPK20.57500020
106LYN0.57008314
107TGFBR20.56995130
108EPHA20.55695066
109CSF1R0.55598915
110MAP3K10.55179189
111TRIB30.54893581
112PBK0.54471139
113ROCK20.54018572
114LCK0.52690407
115TAOK20.51773638
116CDK80.51582934
117CLK10.50835846
118KSR20.48760815
119STK240.46436661
120PRKG20.45733382
121CDC42BPA0.45648023
122TGFBR10.45126313
123MAP3K60.44991134
124PDGFRA0.44655513
125MTOR0.44380655
126STK38L0.43510909
127BMPR20.43435843
128MAPK70.42930423
129EEF2K0.42408472
130AURKB0.42330707
131PIK3CA0.40749438
132RPS6KA60.39645418
133BMPR1B0.39640442
134ATR0.38338436
135STK160.37897073
136STK40.37580655
137IRAK20.37163958
138KDR0.36993536
139PIM20.36273780
140LRRK20.36127925
141CDK90.35795611
142IGF1R0.35309219
143RPS6KL10.34992948
144RPS6KC10.34992948
145MAPK110.33372906
146MAPK30.33066605
147MAP3K80.32371076
148CDK70.31572703

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.01854689
2Protein export_Homo sapiens_hsa030605.84701097
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.27978795
4Sulfur metabolism_Homo sapiens_hsa009202.83688164
5ECM-receptor interaction_Homo sapiens_hsa045122.63252391
6Selenocompound metabolism_Homo sapiens_hsa004502.46123097
7N-Glycan biosynthesis_Homo sapiens_hsa005102.14946506
8Focal adhesion_Homo sapiens_hsa045102.02216660
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.89681575
10Other glycan degradation_Homo sapiens_hsa005111.87984024
11Folate biosynthesis_Homo sapiens_hsa007901.87102108
12Antigen processing and presentation_Homo sapiens_hsa046121.64049105
13Amoebiasis_Homo sapiens_hsa051461.60895187
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60782648
15Small cell lung cancer_Homo sapiens_hsa052221.59845495
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.58683761
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54465840
18Proteoglycans in cancer_Homo sapiens_hsa052051.54277872
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49098647
20Shigellosis_Homo sapiens_hsa051311.47297594
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41996554
22One carbon pool by folate_Homo sapiens_hsa006701.41795149
23Pancreatic cancer_Homo sapiens_hsa052121.40434801
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40036199
25Malaria_Homo sapiens_hsa051441.39999378
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.39257160
27Adherens junction_Homo sapiens_hsa045201.38915176
28Legionellosis_Homo sapiens_hsa051341.35561013
29Tryptophan metabolism_Homo sapiens_hsa003801.33424655
30Lysosome_Homo sapiens_hsa041421.32080209
31Chronic myeloid leukemia_Homo sapiens_hsa052201.29254594
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.27285423
33Starch and sucrose metabolism_Homo sapiens_hsa005001.26669288
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23666569
35Bladder cancer_Homo sapiens_hsa052191.21855420
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.17895875
37Galactose metabolism_Homo sapiens_hsa000521.17613374
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16928059
39Platelet activation_Homo sapiens_hsa046111.12088830
40Fat digestion and absorption_Homo sapiens_hsa049751.11741141
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.07675960
42TNF signaling pathway_Homo sapiens_hsa046681.05629051
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04468637
44ABC transporters_Homo sapiens_hsa020101.01727303
45Peroxisome_Homo sapiens_hsa041461.00648420
46Complement and coagulation cascades_Homo sapiens_hsa046100.97404578
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97368937
48Histidine metabolism_Homo sapiens_hsa003400.97333212
49Pentose phosphate pathway_Homo sapiens_hsa000300.97291035
50Caffeine metabolism_Homo sapiens_hsa002320.95862931
51Renal cell carcinoma_Homo sapiens_hsa052110.94676103
52Type I diabetes mellitus_Homo sapiens_hsa049400.94187180
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91496907
54Primary immunodeficiency_Homo sapiens_hsa053400.90811478
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.90808894
56Staphylococcus aureus infection_Homo sapiens_hsa051500.90032570
57Fatty acid degradation_Homo sapiens_hsa000710.89996676
58Protein digestion and absorption_Homo sapiens_hsa049740.89549932
59Prion diseases_Homo sapiens_hsa050200.88504624
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87445278
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.87376626
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84491384
63Leishmaniasis_Homo sapiens_hsa051400.83275064
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82789798
65Salmonella infection_Homo sapiens_hsa051320.81482392
66Hepatitis C_Homo sapiens_hsa051600.81345077
67Measles_Homo sapiens_hsa051620.80287687
68Viral myocarditis_Homo sapiens_hsa054160.78863981
69Base excision repair_Homo sapiens_hsa034100.77751208
70Endocytosis_Homo sapiens_hsa041440.76761452
71Renin-angiotensin system_Homo sapiens_hsa046140.76330664
72DNA replication_Homo sapiens_hsa030300.75480063
73Pancreatic secretion_Homo sapiens_hsa049720.74027955
74Non-homologous end-joining_Homo sapiens_hsa034500.72845921
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.72046831
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71627284
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70183505
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69756249
79TGF-beta signaling pathway_Homo sapiens_hsa043500.69596932
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68573987
81Hematopoietic cell lineage_Homo sapiens_hsa046400.66965642
82Insulin resistance_Homo sapiens_hsa049310.66590797
83Pathways in cancer_Homo sapiens_hsa052000.65520144
84MicroRNAs in cancer_Homo sapiens_hsa052060.64693015
85Non-small cell lung cancer_Homo sapiens_hsa052230.64650771
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64566512
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62412158
88Herpes simplex infection_Homo sapiens_hsa051680.62159759
89Mismatch repair_Homo sapiens_hsa034300.61746897
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61638822
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61408917
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61077942
93Vitamin digestion and absorption_Homo sapiens_hsa049770.59269766
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58940587
95p53 signaling pathway_Homo sapiens_hsa041150.58928188
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58583480
97Prolactin signaling pathway_Homo sapiens_hsa049170.57462271
98Retinol metabolism_Homo sapiens_hsa008300.57215994
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57049713
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56229934
101PPAR signaling pathway_Homo sapiens_hsa033200.56223551
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56032219
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55381990
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54886247
105Glutathione metabolism_Homo sapiens_hsa004800.52824933
106Systemic lupus erythematosus_Homo sapiens_hsa053220.52032188
107African trypanosomiasis_Homo sapiens_hsa051430.51151386
108Influenza A_Homo sapiens_hsa051640.51106071
109Rheumatoid arthritis_Homo sapiens_hsa053230.49576067
110Thyroid cancer_Homo sapiens_hsa052160.49061560
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48930336
112HTLV-I infection_Homo sapiens_hsa051660.47888509
113Tuberculosis_Homo sapiens_hsa051520.47723450
114Prostate cancer_Homo sapiens_hsa052150.47686362
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.47074043
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.46410432
117Melanoma_Homo sapiens_hsa052180.46263651
118Apoptosis_Homo sapiens_hsa042100.46132751
119Pertussis_Homo sapiens_hsa051330.45549348
120Viral carcinogenesis_Homo sapiens_hsa052030.45353593
121Toxoplasmosis_Homo sapiens_hsa051450.45317773
122Sphingolipid metabolism_Homo sapiens_hsa006000.44376828
123Chemical carcinogenesis_Homo sapiens_hsa052040.44210541
124Regulation of autophagy_Homo sapiens_hsa041400.44151546
125Phenylalanine metabolism_Homo sapiens_hsa003600.43741132
126Lysine degradation_Homo sapiens_hsa003100.43622461
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42541621
128Homologous recombination_Homo sapiens_hsa034400.41690483
129Linoleic acid metabolism_Homo sapiens_hsa005910.41172148
130Vibrio cholerae infection_Homo sapiens_hsa051100.40908194
131B cell receptor signaling pathway_Homo sapiens_hsa046620.40808854
132Pyrimidine metabolism_Homo sapiens_hsa002400.40299747
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40093041
134beta-Alanine metabolism_Homo sapiens_hsa004100.39697921
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39193002
136Acute myeloid leukemia_Homo sapiens_hsa052210.38479326
137Fructose and mannose metabolism_Homo sapiens_hsa000510.38276019
138Arachidonic acid metabolism_Homo sapiens_hsa005900.38165817
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37985755
140Tyrosine metabolism_Homo sapiens_hsa003500.35371192
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.35225430
142Osteoclast differentiation_Homo sapiens_hsa043800.34510860
143Hepatitis B_Homo sapiens_hsa051610.34426036
144Phagosome_Homo sapiens_hsa041450.34222547
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33899933
146Insulin secretion_Homo sapiens_hsa049110.33364198
147Thyroid hormone synthesis_Homo sapiens_hsa049180.33205388

Most similar genes based on co-expression Upload to Enrichr

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