TRANK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.50649065
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.48556050
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.36304710
4negative regulation of cell killing (GO:0031342)6.36304710
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.13665977
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.09028645
7synaptic vesicle maturation (GO:0016188)5.94372340
8locomotory exploration behavior (GO:0035641)5.90188387
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.68040611
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.51201263
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45138713
12antigen processing and presentation of endogenous antigen (GO:0019883)5.37725941
13vocalization behavior (GO:0071625)5.34858155
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.25224274
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23483680
16regulation of B cell receptor signaling pathway (GO:0050855)5.13970316
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.10863587
18positive regulation by organism of defense response of other organism involved in symbiotic interact5.10863587
19modulation by symbiont of host immune response (GO:0052553)5.10863587
20positive regulation by symbiont of host defense response (GO:0052509)5.10863587
21modulation by symbiont of host defense response (GO:0052031)5.10863587
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.10863587
23synaptic vesicle exocytosis (GO:0016079)5.10169209
24regulation of glutamate receptor signaling pathway (GO:1900449)4.99727762
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.89847504
26glutamate secretion (GO:0014047)4.82903529
27regulation of gamma-delta T cell activation (GO:0046643)4.82111470
28regulation of synaptic vesicle exocytosis (GO:2000300)4.77721623
29regulation of synapse structural plasticity (GO:0051823)4.77042092
30regulation of neuronal synaptic plasticity (GO:0048168)4.75725732
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.69162192
32regulation of gamma-delta T cell differentiation (GO:0045586)4.67984648
33macrophage activation involved in immune response (GO:0002281)4.57986324
34protein localization to synapse (GO:0035418)4.56619057
35synaptic transmission, glutamatergic (GO:0035249)4.51905996
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.50432584
37cellular response to type I interferon (GO:0071357)4.39382619
38type I interferon signaling pathway (GO:0060337)4.39382619
39response to type I interferon (GO:0034340)4.37671436
40neuronal action potential propagation (GO:0019227)4.35527236
41detection of other organism (GO:0098543)4.34988185
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.32681963
43neurotransmitter-gated ion channel clustering (GO:0072578)4.32245769
44exploration behavior (GO:0035640)4.31945825
45neurotransmitter secretion (GO:0007269)4.30336504
46regulation of synaptic vesicle transport (GO:1902803)4.26278878
47neuron-neuron synaptic transmission (GO:0007270)4.25239634
48detection of molecule of bacterial origin (GO:0032490)4.25195411
49glutamate receptor signaling pathway (GO:0007215)4.21033506
50response to interleukin-15 (GO:0070672)4.19277292
51B cell receptor signaling pathway (GO:0050853)4.16588929
52negative regulation of lymphocyte mediated immunity (GO:0002707)4.15477309
53long-term memory (GO:0007616)4.11304964
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10750269
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07364038
56regulation of excitatory postsynaptic membrane potential (GO:0060079)4.06235534
57dendritic spine morphogenesis (GO:0060997)4.05259992
58detection of bacterium (GO:0016045)4.04744329
59prepulse inhibition (GO:0060134)4.02277305
60layer formation in cerebral cortex (GO:0021819)4.02126046
61negative thymic T cell selection (GO:0045060)4.01912319
62positive regulation of membrane potential (GO:0045838)4.01862039
63detection of external biotic stimulus (GO:0098581)3.99490696
64negative T cell selection (GO:0043383)3.99419547
65regulation of dendritic spine morphogenesis (GO:0061001)3.98687141
66negative regulation of T cell mediated immunity (GO:0002710)3.95028867
67regulation of interferon-beta biosynthetic process (GO:0045357)3.94922768
68cellular extravasation (GO:0045123)3.93705667
69positive regulation of neurotransmitter transport (GO:0051590)3.89506373
70positive thymic T cell selection (GO:0045059)3.88340317
71microglial cell activation (GO:0001774)3.87359982
72neutrophil activation involved in immune response (GO:0002283)3.87239765
73regulation of postsynaptic membrane potential (GO:0060078)3.86769009
74gamma-aminobutyric acid transport (GO:0015812)3.85065639
75cellular response to interleukin-15 (GO:0071350)3.84693037
76cellular potassium ion homeostasis (GO:0030007)3.82115584
77positive regulation of neurotransmitter secretion (GO:0001956)3.81562548
78neuron cell-cell adhesion (GO:0007158)3.79774839
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.79490841
80neuromuscular process controlling balance (GO:0050885)3.78675661
81leukocyte aggregation (GO:0070486)3.74460922
82regulation of synaptic plasticity (GO:0048167)3.73326571
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.71885474
84response to host immune response (GO:0052572)3.71687328
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.71687328
86positive regulation of synaptic transmission, GABAergic (GO:0032230)3.68084240
87auditory behavior (GO:0031223)3.67538849
88transmission of nerve impulse (GO:0019226)3.66830864
89negative regulation of leukocyte mediated immunity (GO:0002704)3.64784671
90positive T cell selection (GO:0043368)3.63853918
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.63057506
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.61596575
93negative regulation of interleukin-12 production (GO:0032695)3.60633035
94sodium ion export (GO:0071436)3.57301986
95positive regulation of synapse maturation (GO:0090129)3.57118771
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55576762
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.52171109
98response to host (GO:0075136)3.52171109
99response to host defenses (GO:0052200)3.52171109
100membrane hyperpolarization (GO:0060081)3.50298330
101T cell migration (GO:0072678)3.49233281
102regulation of B cell differentiation (GO:0045577)3.47025221
103positive regulation of B cell differentiation (GO:0045579)3.45927990
104activation of protein kinase A activity (GO:0034199)3.45479630
105macrophage activation (GO:0042116)3.43253441
106membrane depolarization during action potential (GO:0086010)3.42771970
107detection of biotic stimulus (GO:0009595)3.42416822
108neuronal ion channel clustering (GO:0045161)3.41211536
109germinal center formation (GO:0002467)3.40531405
110response to auditory stimulus (GO:0010996)3.40063044
111neurotransmitter transport (GO:0006836)3.39803877
112proline transport (GO:0015824)3.39558069
113synaptic transmission, dopaminergic (GO:0001963)3.39161317
114regulation of neurotransmitter secretion (GO:0046928)3.38979206
115regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.38371882
116response to interferon-alpha (GO:0035455)3.38185352
117long-term synaptic potentiation (GO:0060291)3.37731987
118behavioral response to cocaine (GO:0048148)3.37006118
119immunoglobulin mediated immune response (GO:0016064)3.36561762
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.35755933
121interferon-gamma-mediated signaling pathway (GO:0060333)3.33880870
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.33365281
123membrane depolarization (GO:0051899)3.33330847
124T cell selection (GO:0045058)3.32345486
125cerebellar Purkinje cell differentiation (GO:0021702)3.31434260
126striatum development (GO:0021756)3.30754996
127response to peptidoglycan (GO:0032494)3.30457556
128myeloid cell activation involved in immune response (GO:0002275)3.29985492
129neuromuscular process controlling posture (GO:0050884)3.27531879
130antigen processing and presentation via MHC class Ib (GO:0002475)3.25823491
131synaptic vesicle endocytosis (GO:0048488)3.24611283
132regulation of dendritic spine development (GO:0060998)3.24320962
133regulation of neurotransmitter transport (GO:0051588)3.22979652
134positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21769037
135regulation of neurotransmitter levels (GO:0001505)3.21203271
136neutrophil activation (GO:0042119)3.19652536
137response to histamine (GO:0034776)3.19105267
138regulation of T cell tolerance induction (GO:0002664)3.18867866
139behavioral fear response (GO:0001662)3.18849934
140behavioral defense response (GO:0002209)3.18849934
141respiratory burst (GO:0045730)3.18482853
142glycine transport (GO:0015816)3.17918056
143thymic T cell selection (GO:0045061)3.17037066
144negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16575621
145negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16210620
146regulation of vesicle fusion (GO:0031338)3.16061876
147cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15445033
148G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13580497
149regulation of tolerance induction (GO:0002643)3.13551160
150neuron recognition (GO:0008038)3.13084506
151learning (GO:0007612)3.13065145
152positive regulation of interferon-alpha production (GO:0032727)3.12658850
153positive regulation of dendritic spine development (GO:0060999)3.11641894
154positive regulation of synaptic transmission (GO:0050806)3.11520183
155regulation of glutamate secretion (GO:0014048)3.11010782
156activated T cell proliferation (GO:0050798)3.10557385
157production of molecular mediator involved in inflammatory response (GO:0002532)3.09962042
158positive regulation of dendritic spine morphogenesis (GO:0061003)3.09865449
159positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06987405
160regulation of female receptivity (GO:0045924)3.06982742
161visual learning (GO:0008542)3.06965929
162regulation of voltage-gated calcium channel activity (GO:1901385)3.06792996
163gamma-aminobutyric acid signaling pathway (GO:0007214)3.06746005
164neutrophil mediated immunity (GO:0002446)3.06287558
165neuromuscular process (GO:0050905)3.05397939
166dopamine receptor signaling pathway (GO:0007212)3.04980853
167cell communication by electrical coupling (GO:0010644)3.04424634
168dendrite morphogenesis (GO:0048813)3.02610137
169dendritic spine organization (GO:0097061)3.02468558
170negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.02186812
171negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01970017
172response to amphetamine (GO:0001975)3.01473653
173regulation of alpha-beta T cell proliferation (GO:0046640)3.00473694
174positive regulation of granulocyte differentiation (GO:0030854)3.00158852
175regulation of synaptic transmission (GO:0050804)2.98377987
176regulation of regulatory T cell differentiation (GO:0045589)2.96905594
177negative regulation of erythrocyte differentiation (GO:0045647)2.96166552
178negative regulation of type 2 immune response (GO:0002829)2.96138829
179negative regulation of amino acid transport (GO:0051956)2.95653271
180regulation of ARF protein signal transduction (GO:0032012)2.95337472
181negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95027570
182negative regulation of T-helper cell differentiation (GO:0045623)2.95027570
183dendritic cell migration (GO:0036336)2.94397731
184defense response to protozoan (GO:0042832)2.93331637
185regulation of T cell mediated cytotoxicity (GO:0001914)2.90892384
186regulation of interferon-alpha production (GO:0032647)2.90767109
187granulocyte activation (GO:0036230)2.87278269
188regulation of necroptotic process (GO:0060544)2.87090137
189positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84436192
190dendritic cell chemotaxis (GO:0002407)2.81711891
191myeloid leukocyte mediated immunity (GO:0002444)2.81375102
192response to muramyl dipeptide (GO:0032495)2.81355828
193regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81293733
194positive regulation of tolerance induction (GO:0002645)2.80219412
195negative regulation of adaptive immune response (GO:0002820)2.78025250
196tolerance induction (GO:0002507)2.77241730
197negative regulation of innate immune response (GO:0045824)2.75262555
198regulation of MHC class I biosynthetic process (GO:0045343)2.74396182
199regulation of T-helper 2 cell differentiation (GO:0045628)2.74088144
200regulation of mast cell degranulation (GO:0043304)2.73001438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.30218498
2EZH2_22144423_ChIP-Seq_EOC_Human5.91784162
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.85057756
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.59752109
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.06115866
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.82420540
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.35650753
8GBX2_23144817_ChIP-Seq_PC3_Human3.30441859
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27811855
10RARB_27405468_Chip-Seq_BRAIN_Mouse3.15001880
11RUNX_20019798_ChIP-Seq_JUKART_Human3.11906546
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04209113
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97469598
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96637293
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96539788
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95629122
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.94811257
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94598045
19DROSHA_22980978_ChIP-Seq_HELA_Human2.90345959
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68725031
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68725031
22* REST_21632747_ChIP-Seq_MESCs_Mouse2.65270297
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60584282
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56368125
25* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55885671
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53580283
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53365995
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.52913801
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50764644
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49800699
31MYB_26560356_Chip-Seq_TH2_Human2.47032277
32SCL_19346495_ChIP-Seq_HPC-7_Human2.42356594
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36871451
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36064161
35* EZH2_27304074_Chip-Seq_ESCs_Mouse2.35817673
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31594051
37* SPI1_23127762_ChIP-Seq_K562_Human2.30513644
38SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25372661
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23238164
40EZH2_27294783_Chip-Seq_ESCs_Mouse2.21050980
41REST_18959480_ChIP-ChIP_MESCs_Mouse2.20674174
42RNF2_27304074_Chip-Seq_ESCs_Mouse2.19615764
43VDR_24763502_ChIP-Seq_THP-1_Human2.14245157
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11803153
45* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.11035568
46MAF_26560356_Chip-Seq_TH1_Human2.08528672
47EED_16625203_ChIP-ChIP_MESCs_Mouse2.08290856
48GATA1_22025678_ChIP-Seq_K562_Human2.07317845
49SPI1_23547873_ChIP-Seq_NB4_Human2.07012598
50MYB_26560356_Chip-Seq_TH1_Human2.04233283
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03339659
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01581060
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01509206
54STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00544636
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93904799
56VDR_21846776_ChIP-Seq_THP-1_Human1.90788010
57MYC_22102868_ChIP-Seq_BL_Human1.84510531
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83656785
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.82186402
60UTX_26944678_Chip-Seq_JUKART_Human1.81820467
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81682737
62VDR_24787735_ChIP-Seq_THP-1_Human1.80039890
63GATA3_27048872_Chip-Seq_THYMUS_Human1.78712908
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.78620677
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78462068
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.77480700
67TCF7_22412390_ChIP-Seq_EML_Mouse1.76999012
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76176811
69AR_21572438_ChIP-Seq_LNCaP_Human1.74783679
70* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70121980
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67158189
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64868712
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.64686839
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53147900
75KDM2B_26808549_Chip-Seq_DND41_Human1.50521806
76SMAD4_21799915_ChIP-Seq_A2780_Human1.49579769
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47683765
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46905739
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42418621
80GATA1_19941826_ChIP-Seq_K562_Human1.42415779
81MAF_26560356_Chip-Seq_TH2_Human1.39979993
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39971021
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39124908
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37679036
85TAF15_26573619_Chip-Seq_HEK293_Human1.37537837
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37412100
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35517315
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.34286805
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32595350
90PU_27001747_Chip-Seq_BMDM_Mouse1.30482015
91GATA3_26560356_Chip-Seq_TH2_Human1.29910307
92* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29740652
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.29632108
94KDM2B_26808549_Chip-Seq_K562_Human1.29283806
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.29053315
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28902108
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26884760
98* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25901688
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25621266
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24612951
101AR_19668381_ChIP-Seq_PC3_Human1.24191768
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23809310
103STAT3_23295773_ChIP-Seq_U87_Human1.22640627
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22397805
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21859617
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20528944
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19791681
108ZNF274_21170338_ChIP-Seq_K562_Hela1.19060044
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.18762360
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17916377
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16181282
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15956414
113GATA2_19941826_ChIP-Seq_K562_Human1.15592152
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14966295
115ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13207283
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.12631731
117* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11323002
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10763579
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10698674
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10504457
121* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10356177
122KDM2B_26808549_Chip-Seq_JURKAT_Human1.09865817
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09364975
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08952147
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08490748
126SMAD_19615063_ChIP-ChIP_OVARY_Human1.07551323
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07491650
128TCF4_23295773_ChIP-Seq_U87_Human1.07428382
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06221262
130ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05145809
131AR_25329375_ChIP-Seq_VCAP_Human1.05061850
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04954283
133P300_19829295_ChIP-Seq_ESCs_Human1.04903862
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03779787
135ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03401252
136ARNT_22903824_ChIP-Seq_MCF-7_Human1.02301687
137SMAD3_21741376_ChIP-Seq_HESCs_Human1.02096968
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01366758
139YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01242861
140AHR_22903824_ChIP-Seq_MCF-7_Human1.00577556
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00102000
142GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99933036
143* CBX2_27304074_Chip-Seq_ESCs_Mouse0.99548795
144TP53_16413492_ChIP-PET_HCT116_Human0.99427242
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97798868
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97705803
147PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96933909
148CTCF_27219007_Chip-Seq_Bcells_Human0.96058635
149RNF2_27304074_Chip-Seq_NSC_Mouse0.95198296
150ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94953869
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94620161
152PIAS1_25552417_ChIP-Seq_VCAP_Human0.94159742
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.93875373
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92967519
155SMAD4_21741376_ChIP-Seq_HESCs_Human0.92553610
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92203474
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92057560
158CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91602743
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91162613
160CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91140694
161* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90875678
162TET1_21490601_ChIP-Seq_MESCs_Mouse0.90661391
163ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89766968
164* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89734029
165* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88554466
166CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88136784
167* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87632135
168PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87587882
169NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87523821
170GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86969342
171STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86675597
172ELK3_25401928_ChIP-Seq_HUVEC_Human0.86541367
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86480100
174DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86412072
175ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85893140
176RUNX2_22187159_ChIP-Seq_PCA_Human0.85774563
177TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85618390
178FOXO3_23340844_ChIP-Seq_DLD1_Human0.85565186
179* SMRT_27268052_Chip-Seq_Bcells_Human0.84576982
180KLF4_19829295_ChIP-Seq_ESCs_Human0.84100080
181PRDM14_20953172_ChIP-Seq_ESCs_Human0.82513948
182TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82101790
183BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77935733
184SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77867007
185PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75944683
186SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71151870
187RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68354601
188KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.66262370
189FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.65913473
190TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64243963
191CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.63909876
192* NCOR1_26117541_ChIP-Seq_K562_Human0.63518065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.16057745
2MP0002822_catalepsy4.83826456
3MP0003880_abnormal_central_pattern4.63865227
4MP0003724_increased_susceptibility_to4.63587641
5MP0003635_abnormal_synaptic_transmissio4.26574276
6MP0001835_abnormal_antigen_presentation4.06522848
7MP0009745_abnormal_behavioral_response3.60580689
8MP0003436_decreased_susceptibility_to3.58509578
9MP0004270_analgesia3.53851740
10MP0003303_peritoneal_inflammation3.49178218
11MP0002063_abnormal_learning/memory/cond3.44414012
12MP0002064_seizures3.19783453
13MP0001800_abnormal_humoral_immune3.16078359
14MP0009046_muscle_twitch3.15786747
15MP0003763_abnormal_thymus_physiology3.06746309
16MP0002572_abnormal_emotion/affect_behav2.89735906
17MP0005671_abnormal_response_to2.82935868
18MP0001968_abnormal_touch/_nociception2.78958674
19MP0005387_immune_system_phenotype2.78459127
20MP0001790_abnormal_immune_system2.78459127
21MP0005000_abnormal_immune_tolerance2.78312692
22MP0005025_abnormal_response_to2.75527120
23MP0002419_abnormal_innate_immunity2.72906219
24MP0005423_abnormal_somatic_nervous2.71845462
25MP0001486_abnormal_startle_reflex2.71061830
26MP0009785_altered_susceptibility_to2.69215124
27MP0000685_abnormal_immune_system2.67899579
28MP0002272_abnormal_nervous_system2.67896941
29MP0002723_abnormal_immune_serum2.60061469
30MP0003300_gastrointestinal_ulcer2.56233189
31MP0002452_abnormal_antigen_presenting2.50092527
32MP0002420_abnormal_adaptive_immunity2.49540505
33MP0001819_abnormal_immune_cell2.46293214
34MP0008260_abnormal_autophagy2.45015646
35MP0006082_CNS_inflammation2.41974615
36MP0002734_abnormal_mechanical_nocicepti2.36393856
37MP0001501_abnormal_sleep_pattern2.26473921
38MP0001440_abnormal_grooming_behavior2.10313105
39MP0002398_abnormal_bone_marrow2.05617993
40MP0003879_abnormal_hair_cell2.03111084
41MP0002736_abnormal_nociception_after2.02066069
42MP0010155_abnormal_intestine_physiology1.99774088
43MP0000716_abnormal_immune_system1.97952801
44MP0002148_abnormal_hypersensitivity_rea1.94091498
45MP0002405_respiratory_system_inflammati1.92760828
46MP0008569_lethality_at_weaning1.89899841
47MP0003866_abnormal_defecation1.89210250
48MP0002735_abnormal_chemical_nociception1.87388694
49MP0009780_abnormal_chondrocyte_physiolo1.85791498
50MP0005464_abnormal_platelet_physiology1.84548302
51MP0003191_abnormal_cellular_cholesterol1.82509675
52MP0002909_abnormal_adrenal_gland1.82263210
53MP0001970_abnormal_pain_threshold1.81003243
54MP0002733_abnormal_thermal_nociception1.80697030
55MP0001533_abnormal_skeleton_physiology1.80679731
56MP0005451_abnormal_body_composition1.80235847
57MP0002067_abnormal_sensory_capabilities1.79092778
58MP0002166_altered_tumor_susceptibility1.79089289
59MP0004381_abnormal_hair_follicle1.78366922
60MP0003183_abnormal_peptide_metabolism1.77871545
61MP0004947_skin_inflammation1.77625256
62MP0002396_abnormal_hematopoietic_system1.77324419
63MP0005646_abnormal_pituitary_gland1.75651418
64MP0004811_abnormal_neuron_physiology1.72789105
65MP0002557_abnormal_social/conspecific_i1.72636684
66MP0001845_abnormal_inflammatory_respons1.69743874
67MP0003172_abnormal_lysosome_physiology1.69354796
68MP0004924_abnormal_behavior1.69168982
69MP0005386_behavior/neurological_phenoty1.69168982
70MP0000689_abnormal_spleen_morphology1.65897581
71MP0002722_abnormal_immune_system1.64845866
72MP0000703_abnormal_thymus_morphology1.61876481
73MP0000465_gastrointestinal_hemorrhage1.60876142
74MP0003787_abnormal_imprinting1.59857210
75MP0003329_amyloid_beta_deposits1.56793685
76MP0002429_abnormal_blood_cell1.52991136
77MP0002184_abnormal_innervation1.52607204
78MP0009333_abnormal_splenocyte_physiolog1.52570988
79MP0004885_abnormal_endolymph1.52135000
80MP0005310_abnormal_salivary_gland1.51840819
81MP0004883_abnormal_blood_vessel1.49832278
82MP0001529_abnormal_vocalization1.46338612
83MP0004858_abnormal_nervous_system1.44935932
84MP0000778_abnormal_nervous_system1.44166154
85MP0001984_abnormal_olfaction1.43802499
86MP0003828_pulmonary_edema1.41681454
87MP0000955_abnormal_spinal_cord1.41318728
88MP0002132_abnormal_respiratory_system1.37073201
89MP0002066_abnormal_motor_capabilities/c1.35920237
90MP0003633_abnormal_nervous_system1.34643685
91MP0000569_abnormal_digit_pigmentation1.33630952
92MP0002882_abnormal_neuron_morphology1.33322607
93MP0001851_eye_inflammation1.32917371
94MP0009278_abnormal_bone_marrow1.32149427
95MP0008469_abnormal_protein_level1.31840166
96MP0000858_altered_metastatic_potential1.30642438
97MP0009764_decreased_sensitivity_to1.25340065
98MP0002998_abnormal_bone_remodeling1.23573025
99MP0001502_abnormal_circadian_rhythm1.16808659
100MP0008872_abnormal_physiological_respon1.16653704
101MP0002006_tumorigenesis1.14615181
102MP0004808_abnormal_hematopoietic_stem1.14189245
103MP0000751_myopathy1.14083741
104MP0001188_hyperpigmentation1.13953084
105MP0003631_nervous_system_phenotype1.13511350
106MP0001545_abnormal_hematopoietic_system1.13245842
107MP0005397_hematopoietic_system_phenotyp1.13245842
108MP0001177_atelectasis1.12376592
109MP0003656_abnormal_erythrocyte_physiolo1.12095477
110MP0008877_abnormal_DNA_methylation1.11417303
111MP0005164_abnormal_response_to1.10874791
112MP0005645_abnormal_hypothalamus_physiol1.09897563
113MP0001905_abnormal_dopamine_level1.06450724
114MP0003690_abnormal_glial_cell1.05436529
115MP0002152_abnormal_brain_morphology1.03311786
116MP0008874_decreased_physiological_sensi1.03295192
117MP0003283_abnormal_digestive_organ1.03032357
118MP0003075_altered_response_to1.02724689
119MP0005075_abnormal_melanosome_morpholog1.01667778
120MP0006276_abnormal_autonomic_nervous1.01041565
121MP0005166_decreased_susceptibility_to1.00423572
122MP0003091_abnormal_cell_migration0.99528157
123MP0000015_abnormal_ear_pigmentation0.98676605
124MP0008961_abnormal_basal_metabolism0.98059260
125MP0004142_abnormal_muscle_tone0.98035763
126MP0005167_abnormal_blood-brain_barrier0.97752668
127MP0004145_abnormal_muscle_electrophysio0.95608203
128MP0005551_abnormal_eye_electrophysiolog0.94325706
129MP0003448_altered_tumor_morphology0.93853648
130MP0001873_stomach_inflammation0.93441592
131MP0005409_darkened_coat_color0.93432298
132MP0002069_abnormal_eating/drinking_beha0.93328099
133MP0002229_neurodegeneration0.92862136
134MP0003122_maternal_imprinting0.91535588
135MP0002277_abnormal_respiratory_mucosa0.88596238
136MP0004742_abnormal_vestibular_system0.88350751
137MP0001958_emphysema0.87792204
138MP0004085_abnormal_heartbeat0.87662046
139MP0002090_abnormal_vision0.87548168
140MP0001663_abnormal_digestive_system0.86390115
141MP0008004_abnormal_stomach_pH0.84665909
142MP0009763_increased_sensitivity_to0.84237523
143MP0002009_preneoplasia0.81916341
144MP0003632_abnormal_nervous_system0.81469501
145MP0000013_abnormal_adipose_tissue0.79761497
146MP0004130_abnormal_muscle_cell0.79673580
147MP0003221_abnormal_cardiomyocyte_apopto0.79517000
148MP0000920_abnormal_myelination0.79477535
149MP0002138_abnormal_hepatobiliary_system0.79312223
150MP0001986_abnormal_taste_sensitivity0.78947020
151MP0001485_abnormal_pinna_reflex0.78339443
152MP0008995_early_reproductive_senescence0.76880380
153MP0005535_abnormal_body_temperature0.76205552
154MP0000631_abnormal_neuroendocrine_gland0.75805606
155MP0001853_heart_inflammation0.75014102
156MP0002332_abnormal_exercise_endurance0.74827491
157MP0003634_abnormal_glial_cell0.74520635
158MP0000249_abnormal_blood_vessel0.73487484
159MP0002933_joint_inflammation0.72910356
160MP0003045_fibrosis0.69925281
161MP0005623_abnormal_meninges_morphology0.67396303
162MP0005390_skeleton_phenotype0.66440961
163MP0001963_abnormal_hearing_physiology0.66160238
164MP0004484_altered_response_of0.65733511
165MP0009765_abnormal_xenobiotic_induced0.65020982
166MP0000604_amyloidosis0.63430303
167MP0008057_abnormal_DNA_replication0.63330040
168MP0005174_abnormal_tail_pigmentation0.62998729
169MP0010234_abnormal_vibrissa_follicle0.62311717
170MP0010386_abnormal_urinary_bladder0.61755731
171MP0003137_abnormal_impulse_conducting0.61151645
172MP0004043_abnormal_pH_regulation0.60394691
173MP0002752_abnormal_somatic_nervous0.59595715
174MP0005499_abnormal_olfactory_system0.59342789
175MP0005394_taste/olfaction_phenotype0.59342789
176MP0002133_abnormal_respiratory_system0.59157069
177MP0005388_respiratory_system_phenotype0.59157069
178MP0004233_abnormal_muscle_weight0.57013382
179MP0004510_myositis0.57001252
180MP0000490_abnormal_crypts_of0.56644475
181MP0003795_abnormal_bone_structure0.56379444
182MP0004264_abnormal_extraembryonic_tissu0.56353175
183MP0004215_abnormal_myocardial_fiber0.56043208
184MP0005410_abnormal_fertilization0.55304707
185MP0001664_abnormal_digestion0.53314556
186MP0003698_abnormal_male_reproductive0.51092411
187MP0010769_abnormal_survival0.50237203
188MP0001943_abnormal_respiration0.48717798
189MP0010768_mortality/aging0.47917044
190MP0010770_preweaning_lethality0.47435063

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.07775236
2Myokymia (HP:0002411)8.05892136
3Focal seizures (HP:0007359)6.08878442
4Eczematoid dermatitis (HP:0000976)6.02098954
5Recurrent bacterial skin infections (HP:0005406)5.41158583
6Recurrent abscess formation (HP:0002722)5.19433352
7Myositis (HP:0100614)4.94235997
8Orchitis (HP:0100796)4.73062907
9Visual hallucinations (HP:0002367)4.71624978
10Epileptic encephalopathy (HP:0200134)4.66299159
11Retrobulbar optic neuritis (HP:0100654)4.58562960
12Optic neuritis (HP:0100653)4.58562960
13T lymphocytopenia (HP:0005403)4.55087406
14Abnormality of T cell number (HP:0011839)4.37377763
15Recurrent fungal infections (HP:0002841)4.29921699
16Febrile seizures (HP:0002373)4.25994175
17Ankle clonus (HP:0011448)4.24141399
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.17391206
19Gastrointestinal infarctions (HP:0005244)4.11891924
20Elevated erythrocyte sedimentation rate (HP:0003565)4.07098753
21Recurrent gram-negative bacterial infections (HP:0005420)4.07082211
22Spontaneous hematomas (HP:0007420)4.06168152
23Abnormality of macrophages (HP:0004311)4.05768867
24Progressive cerebellar ataxia (HP:0002073)4.02468836
25Generalized tonic-clonic seizures (HP:0002069)4.01553890
26Action tremor (HP:0002345)3.97416446
27Atonic seizures (HP:0010819)3.93499573
28Recurrent cutaneous fungal infections (HP:0011370)3.83811305
29Chronic mucocutaneous candidiasis (HP:0002728)3.83811305
30Absence seizures (HP:0002121)3.80656982
31Recurrent skin infections (HP:0001581)3.79535984
32Gaze-evoked nystagmus (HP:0000640)3.78910386
33Meningitis (HP:0001287)3.78767564
34Stomatitis (HP:0010280)3.71495571
35Gingivitis (HP:0000230)3.70337116
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.69041297
37Poor eye contact (HP:0000817)3.66734586
38Mediastinal lymphadenopathy (HP:0100721)3.61076909
39Broad-based gait (HP:0002136)3.58536868
40Vasculitis (HP:0002633)3.58018173
41Impaired vibration sensation in the lower limbs (HP:0002166)3.55093831
42Abnormality of the lower motor neuron (HP:0002366)3.54292511
43Dialeptic seizures (HP:0011146)3.54142594
44Recurrent viral infections (HP:0004429)3.44590406
45Encephalitis (HP:0002383)3.42111640
46Keratoconjunctivitis sicca (HP:0001097)3.40900166
47Dysdiadochokinesis (HP:0002075)3.40356573
48Urinary bladder sphincter dysfunction (HP:0002839)3.39751037
49Depression (HP:0000716)3.38157352
50Abnormal social behavior (HP:0012433)3.30506641
51Impaired social interactions (HP:0000735)3.30506641
52Supranuclear gaze palsy (HP:0000605)3.29096763
53Torticollis (HP:0000473)3.27984177
54Cellulitis (HP:0100658)3.25104018
55Dysmetria (HP:0001310)3.20666414
56Abnormality of T cells (HP:0002843)3.14542071
57Obstructive lung disease (HP:0006536)3.14074824
58Chronic obstructive pulmonary disease (HP:0006510)3.14074824
59Postural instability (HP:0002172)3.13106234
60Annular pancreas (HP:0001734)3.09962757
61Keratoconjunctivitis (HP:0001096)3.09549827
62Gingival bleeding (HP:0000225)3.07048109
63Anxiety (HP:0000739)3.04112115
64Peritonitis (HP:0002586)2.99709182
65Hemoptysis (HP:0002105)2.99513344
66Recurrent bronchitis (HP:0002837)2.99125771
67Leukocytosis (HP:0001974)2.97135327
68Chest pain (HP:0100749)2.96381395
69Inflammation of the large intestine (HP:0002037)2.96192942
70Panhypogammaglobulinemia (HP:0003139)2.93917933
71Focal dystonia (HP:0004373)2.93600599
72Impaired smooth pursuit (HP:0007772)2.88981776
73Urticaria (HP:0001025)2.86697430
74Gastrointestinal inflammation (HP:0004386)2.86474715
75Colitis (HP:0002583)2.85956818
76Amblyopia (HP:0000646)2.82826220
77Truncal ataxia (HP:0002078)2.82534821
78Urinary urgency (HP:0000012)2.81291274
79Prolonged bleeding time (HP:0003010)2.80033340
80Pulmonary infiltrates (HP:0002113)2.79357968
81Spastic gait (HP:0002064)2.78489486
82Increased IgE level (HP:0003212)2.76509465
83Hemiplegia (HP:0002301)2.76026564
84Papilledema (HP:0001085)2.75663701
85Genetic anticipation (HP:0003743)2.73674507
86Abnormal eating behavior (HP:0100738)2.73656141
87Scanning speech (HP:0002168)2.71442219
88Agammaglobulinemia (HP:0004432)2.70742292
89Arterial thrombosis (HP:0004420)2.70694803
90Craniofacial dystonia (HP:0012179)2.69381251
91Hemiparesis (HP:0001269)2.69288710
92Dysmetric saccades (HP:0000641)2.68196250
93Granulocytopenia (HP:0001913)2.65941343
94Pointed chin (HP:0000307)2.65072431
95Stereotypic behavior (HP:0000733)2.63605420
96Slow saccadic eye movements (HP:0000514)2.61862333
97Abnormality of ocular smooth pursuit (HP:0000617)2.61755677
98Epistaxis (HP:0000421)2.61212256
99Intention tremor (HP:0002080)2.60868269
100Pustule (HP:0200039)2.60266082
101Pulmonary embolism (HP:0002204)2.59209248
102Abnormality of the fingertips (HP:0001211)2.57929409
103Eosinophilia (HP:0001880)2.55556485
104Autoimmune hemolytic anemia (HP:0001890)2.54114289
105Osteomyelitis (HP:0002754)2.53696152
106Resting tremor (HP:0002322)2.52854076
107Bradykinesia (HP:0002067)2.52365572
108Mutism (HP:0002300)2.52285742
109Hypochromic microcytic anemia (HP:0004840)2.51015416
110Clonus (HP:0002169)2.50459848
111Hyperventilation (HP:0002883)2.48978695
112Impaired vibratory sensation (HP:0002495)2.48430842
113Lymphopenia (HP:0001888)2.47167225
114Hypochromic anemia (HP:0001931)2.46212369
115Ventricular fibrillation (HP:0001663)2.43470009
116Abnormality of cells of the lymphoid lineage (HP:0012140)2.40009751
117Status epilepticus (HP:0002133)2.38155380
118Increased IgM level (HP:0003496)2.33902793
119Viral hepatitis (HP:0006562)2.33328792
120Abnormality of the peritoneum (HP:0002585)2.32653377
121Excessive salivation (HP:0003781)2.31687152
122Drooling (HP:0002307)2.31687152
123Lower limb amyotrophy (HP:0007210)2.29616104
124Lower limb muscle weakness (HP:0007340)2.28326610
125Epileptiform EEG discharges (HP:0011182)2.27627419
126Anorexia (HP:0002039)2.26622648
127Microcytic anemia (HP:0001935)2.26527835
128Progressive inability to walk (HP:0002505)2.25652119
129Abnormality of eosinophils (HP:0001879)2.24511204
130Sepsis (HP:0100806)2.23636701
131Chronic otitis media (HP:0000389)2.23246668
132Episodic fever (HP:0001954)2.22352806
133Insomnia (HP:0100785)2.22289727
134Ankyloglossia (HP:0010296)2.20912410
135Abnormality of T cell physiology (HP:0011840)2.20764686
136Gastrointestinal stroma tumor (HP:0100723)2.17340232
137EEG with generalized epileptiform discharges (HP:0011198)2.16325789
138Abnormality of binocular vision (HP:0011514)2.14348894
139Diplopia (HP:0000651)2.14348894
140Abnormality of the pleura (HP:0002103)2.11299502
141Neuronal loss in central nervous system (HP:0002529)2.11255179
142Subacute progressive viral hepatitis (HP:0006572)2.11085069
143Abnormal EKG (HP:0003115)2.10300383
144Chronic diarrhea (HP:0002028)2.09310735
145Papilloma (HP:0012740)2.08288825
146Verrucae (HP:0200043)2.08288825
147Megalencephaly (HP:0001355)2.07794626
148Autoimmune thrombocytopenia (HP:0001973)2.07500532
149Neurofibrillary tangles (HP:0002185)2.06871032
150Hypsarrhythmia (HP:0002521)2.05782453
151Gangrene (HP:0100758)2.05547989
152IgM deficiency (HP:0002850)2.05311984
153Bundle branch block (HP:0011710)2.03260682
154Prolonged QT interval (HP:0001657)2.02242435
155Cerebral inclusion bodies (HP:0100314)2.01234168
156Hypergammaglobulinemia (HP:0010702)1.99118204
157Abnormality of the endocardium (HP:0004306)1.98717636
158Absent speech (HP:0001344)1.97842737
159Incomplete penetrance (HP:0003829)1.95831080
160Abnormality of saccadic eye movements (HP:0000570)1.94484807
161Skin ulcer (HP:0200042)1.93318978
162Gait ataxia (HP:0002066)1.93311984
163Insidious onset (HP:0003587)1.91142769
164Termporal pattern (HP:0011008)1.91142769
165Limb dystonia (HP:0002451)1.90572562
166Hypoventilation (HP:0002791)1.88166648
167Fetal akinesia sequence (HP:0001989)1.87536817
168Acute hepatic failure (HP:0006554)1.87169994
169Obstructive sleep apnea (HP:0002870)1.86825214
170Distal upper limb amyotrophy (HP:0007149)1.86688425
171Upper limb amyotrophy (HP:0009129)1.86688425
172Hematochezia (HP:0002573)1.84208674
173Glomerulopathy (HP:0100820)1.83346909
174Hypoplasia of the thymus (HP:0000778)1.82695598
175Abnormality of the corticospinal tract (HP:0002492)1.82440242
176Recurrent pneumonia (HP:0006532)1.81294909
177Acne (HP:0001061)1.77595318
178Periodontitis (HP:0000704)1.77555017
179Emphysema (HP:0002097)1.77466971
180Amyloidosis (HP:0011034)1.77454092
181Generalized myoclonic seizures (HP:0002123)1.77218251
182Abnormality of the periventricular white matter (HP:0002518)1.77132631
183Tetraplegia (HP:0002445)1.76583493
184Malnutrition (HP:0004395)1.76370205
185Neoplasm of the heart (HP:0100544)1.76005753
186Rigidity (HP:0002063)1.74739088
187Lower limb asymmetry (HP:0100559)1.74071020
188Vertigo (HP:0002321)1.74041933
189Skin rash (HP:0000988)1.73529378
190Joint swelling (HP:0001386)1.72975908
191Male infertility (HP:0003251)1.72673941
192Amyotrophic lateral sclerosis (HP:0007354)1.71517084
193Inability to walk (HP:0002540)1.71002384
194Blue irides (HP:0000635)1.67585054
195Inappropriate behavior (HP:0000719)1.64453703
196Deeply set eye (HP:0000490)1.63970859
197Agitation (HP:0000713)1.62783758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.72044211
2NTRK34.90810531
3MAP4K13.71785889
4MAP3K93.69769273
5DAPK23.16709057
6TYK23.08437049
7BLK3.01523165
8MAP3K42.88524944
9PRKD32.68250623
10ERN12.52336363
11IRAK42.41021018
12JAK32.38631211
13MINK12.31908855
14CSK2.27133916
15KSR22.25125686
16MAP2K32.24582655
17MARK12.23167752
18IKBKE2.21543878
19MAP2K72.18013631
20PAK62.13975011
21GRK62.11378211
22JAK12.09629408
23TXK2.03573651
24NTRK22.02426453
25CAMKK12.02120186
26TNIK1.98073490
27BTK1.87481469
28ZAP701.85701880
29TYRO31.85117737
30DAPK11.81349646
31FGFR41.80936470
32RIPK41.79448570
33SYK1.75160059
34TAOK31.67078229
35EPHB11.61564540
36FGFR31.61426024
37MAP2K41.60817181
38NTRK11.60732507
39MAP3K141.58126636
40CDK51.57155419
41KSR11.56977779
42HCK1.54760579
43FES1.52698339
44STK381.52479813
45PRPF4B1.51812001
46JAK21.42246389
47ITK1.41934378
48KIT1.40117664
49SIK21.38240571
50TAOK11.32741827
51MAP3K131.30292095
52MAP3K21.25115594
53LYN1.24065940
54NLK1.21804692
55LCK1.20308754
56MAPK131.15091116
57TBK11.14945631
58TEC1.14709516
59PIK3CG1.12948926
60MAP3K31.11330209
61ARAF1.09295597
62PRKCG1.06027575
63CAMKK21.04470148
64MAP3K121.04280960
65CSF1R1.01845778
66CDK190.98967929
67SGK4940.98916965
68SGK2230.98916965
69YES10.98814422
70CAMK10.97407985
71PRKCH0.95840366
72PLK20.95221730
73PTK2B0.93834995
74MAP3K100.93616021
75STK110.92979265
76CASK0.92691393
77PNCK0.91093002
78MAP3K110.91058981
79RIPK10.90315237
80IRAK10.88864850
81CDK120.87768098
82UHMK10.87600782
83GRK50.87129636
84SGK20.85979617
85MAP3K60.85828660
86CAMK2A0.85380748
87RAF10.85214990
88TRIB30.83332912
89PINK10.82879708
90CDK150.81685691
91CDK180.81639544
92SGK30.81456438
93MARK20.80931594
94SGK10.80846488
95TGFBR20.80364883
96CDC42BPA0.80177546
97MATK0.79281538
98TNK20.78614397
99MARK30.78443340
100RET0.77738957
101ALK0.76868796
102CAMK2B0.74400565
103CDK140.73481267
104STK100.72621096
105HIPK20.71364010
106WNK30.71010943
107NEK60.70871432
108LMTK20.70473185
109CDK11A0.70138510
110LRRK20.68135888
111MAPK70.67923865
112WNK10.67587655
113PDK10.67266572
114PDPK10.65931202
115PIM10.65701134
116PTK60.65480228
117IKBKB0.65277371
118PHKG20.64864784
119PHKG10.64864784
120BMPR20.64646930
121ACVR1B0.64257798
122CAMK1G0.63092545
123IRAK20.62627649
124MAPK120.62191209
125SIK30.60335415
126DYRK1A0.58866454
127MAP3K10.57985581
128RPS6KA30.57782057
129EPHA30.57549225
130PRKCQ0.55418174
131OXSR10.53602396
132CAMK40.53581266
133CSNK1G20.53436257
134MELK0.53406541
135MAP3K70.51584906
136PAK30.51200820
137DAPK30.50838399
138MAPK110.50384987
139SMG10.50135455
140LATS20.49544947
141GRK70.49238831
142DMPK0.49054179
143FYN0.47511053
144MAPK100.47489942
145PRKCZ0.45147441
146PRKD20.44940934
147MAP3K50.44781463
148ICK0.44659134
149NEK10.41288601
150TAOK20.41021793
151BRSK10.40954093
152PDGFRB0.39568310
153CAMK2D0.38360346
154PRKCB0.37294693
155MAP2K10.37155903
156DYRK1B0.36973119
157PRKCE0.36053783
158CAMK2G0.34409853
159FER0.34124321
160MAPK80.30690561
161PDGFRA0.29348600
162GSK3B0.28809690
163FGR0.28227839

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.56321281
2Synaptic vesicle cycle_Homo sapiens_hsa047213.06655344
3Olfactory transduction_Homo sapiens_hsa047403.04789021
4Circadian entrainment_Homo sapiens_hsa047132.85468711
5GABAergic synapse_Homo sapiens_hsa047272.70834601
6Long-term potentiation_Homo sapiens_hsa047202.68769651
7Glutamatergic synapse_Homo sapiens_hsa047242.67870866
8Leishmaniasis_Homo sapiens_hsa051402.67173331
9Morphine addiction_Homo sapiens_hsa050322.66007438
10Amphetamine addiction_Homo sapiens_hsa050312.61509656
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60480975
12Osteoclast differentiation_Homo sapiens_hsa043802.56667701
13B cell receptor signaling pathway_Homo sapiens_hsa046622.44373388
14Staphylococcus aureus infection_Homo sapiens_hsa051502.31112533
15Primary immunodeficiency_Homo sapiens_hsa053402.25831241
16Dopaminergic synapse_Homo sapiens_hsa047282.23076855
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21275513
18Graft-versus-host disease_Homo sapiens_hsa053322.21169671
19Salivary secretion_Homo sapiens_hsa049702.16323468
20Allograft rejection_Homo sapiens_hsa053302.15779008
21Autoimmune thyroid disease_Homo sapiens_hsa053202.07921339
22Aldosterone synthesis and secretion_Homo sapiens_hsa049252.04424223
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02390995
24Measles_Homo sapiens_hsa051622.01317485
25Cocaine addiction_Homo sapiens_hsa050301.98788865
26Cholinergic synapse_Homo sapiens_hsa047251.97696655
27Insulin secretion_Homo sapiens_hsa049111.97070016
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94631065
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92590174
30Gastric acid secretion_Homo sapiens_hsa049711.89443419
31Tuberculosis_Homo sapiens_hsa051521.88173896
32Renin secretion_Homo sapiens_hsa049241.80040886
33T cell receptor signaling pathway_Homo sapiens_hsa046601.78384173
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78161490
35Oxytocin signaling pathway_Homo sapiens_hsa049211.76893416
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.70667843
37Influenza A_Homo sapiens_hsa051641.70517549
38Calcium signaling pathway_Homo sapiens_hsa040201.69206891
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68732655
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67765558
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67509049
42Acute myeloid leukemia_Homo sapiens_hsa052211.65379280
43Long-term depression_Homo sapiens_hsa047301.62527774
44Taste transduction_Homo sapiens_hsa047421.57268920
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52932766
46Toxoplasmosis_Homo sapiens_hsa051451.51145060
47Serotonergic synapse_Homo sapiens_hsa047261.50373426
48Malaria_Homo sapiens_hsa051441.49109281
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.47296140
50cAMP signaling pathway_Homo sapiens_hsa040241.46592691
51Hematopoietic cell lineage_Homo sapiens_hsa046401.45962305
52GnRH signaling pathway_Homo sapiens_hsa049121.45493636
53Antigen processing and presentation_Homo sapiens_hsa046121.41927752
54Nitrogen metabolism_Homo sapiens_hsa009101.39962216
55Hepatitis C_Homo sapiens_hsa051601.37055463
56Herpes simplex infection_Homo sapiens_hsa051681.36171148
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35670238
58Gap junction_Homo sapiens_hsa045401.32833021
59Viral myocarditis_Homo sapiens_hsa054161.31571525
60Hepatitis B_Homo sapiens_hsa051611.31001048
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29772000
62Type II diabetes mellitus_Homo sapiens_hsa049301.29040089
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.28458408
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25839052
65TNF signaling pathway_Homo sapiens_hsa046681.24071040
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21671393
67Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20813471
68Leukocyte transendothelial migration_Homo sapiens_hsa046701.17451344
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16596867
70Pancreatic cancer_Homo sapiens_hsa052121.16339189
71Estrogen signaling pathway_Homo sapiens_hsa049151.11031440
72Glioma_Homo sapiens_hsa052141.10797158
73cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10329314
74Chronic myeloid leukemia_Homo sapiens_hsa052201.09333252
75Axon guidance_Homo sapiens_hsa043601.08477643
76Prolactin signaling pathway_Homo sapiens_hsa049171.07744912
77Asthma_Homo sapiens_hsa053101.05838667
78Vascular smooth muscle contraction_Homo sapiens_hsa042701.01483884
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00697036
80ErbB signaling pathway_Homo sapiens_hsa040121.00569686
81Dorso-ventral axis formation_Homo sapiens_hsa043200.98104160
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97693855
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97444757
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.97246424
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95594092
86Collecting duct acid secretion_Homo sapiens_hsa049660.95227913
87Melanogenesis_Homo sapiens_hsa049160.94957579
88Legionellosis_Homo sapiens_hsa051340.94013590
89Apoptosis_Homo sapiens_hsa042100.89939642
90Phagosome_Homo sapiens_hsa041450.89095349
91Oocyte meiosis_Homo sapiens_hsa041140.88254499
92FoxO signaling pathway_Homo sapiens_hsa040680.87990963
93Pancreatic secretion_Homo sapiens_hsa049720.85868260
94Pertussis_Homo sapiens_hsa051330.84528666
95Phototransduction_Homo sapiens_hsa047440.81077679
96Dilated cardiomyopathy_Homo sapiens_hsa054140.80481295
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79914334
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78674513
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78207827
100Cardiac muscle contraction_Homo sapiens_hsa042600.77440528
101Thyroid hormone synthesis_Homo sapiens_hsa049180.76822025
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76451021
103Notch signaling pathway_Homo sapiens_hsa043300.75481214
104Choline metabolism in cancer_Homo sapiens_hsa052310.75206913
105MAPK signaling pathway_Homo sapiens_hsa040100.72298386
106Other glycan degradation_Homo sapiens_hsa005110.69089845
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67780658
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64370297
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.64348180
110VEGF signaling pathway_Homo sapiens_hsa043700.64162793
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.63085484
112Rap1 signaling pathway_Homo sapiens_hsa040150.63075889
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62842152
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61452052
115Insulin resistance_Homo sapiens_hsa049310.60179354
116Alcoholism_Homo sapiens_hsa050340.59508444
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59501355
118Viral carcinogenesis_Homo sapiens_hsa052030.59268708
119Circadian rhythm_Homo sapiens_hsa047100.58960221
120Amoebiasis_Homo sapiens_hsa051460.58355472
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58095296
122Colorectal cancer_Homo sapiens_hsa052100.57882871
123Vibrio cholerae infection_Homo sapiens_hsa051100.57686680
124Shigellosis_Homo sapiens_hsa051310.56620064
125Bile secretion_Homo sapiens_hsa049760.56465631
126mTOR signaling pathway_Homo sapiens_hsa041500.56436487
127Prostate cancer_Homo sapiens_hsa052150.56337767
128Ras signaling pathway_Homo sapiens_hsa040140.56088556
129Inositol phosphate metabolism_Homo sapiens_hsa005620.55626949
130Ovarian steroidogenesis_Homo sapiens_hsa049130.55346436
131HTLV-I infection_Homo sapiens_hsa051660.54510179
132Salmonella infection_Homo sapiens_hsa051320.53568350
133Glucagon signaling pathway_Homo sapiens_hsa049220.53117207
134Rheumatoid arthritis_Homo sapiens_hsa053230.52458996
135Non-small cell lung cancer_Homo sapiens_hsa052230.51955770
136Epstein-Barr virus infection_Homo sapiens_hsa051690.51935913
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51620548
138HIF-1 signaling pathway_Homo sapiens_hsa040660.50986621
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50960796
140Type I diabetes mellitus_Homo sapiens_hsa049400.50885019
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50881255
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.49364761
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49149095
144Endocytosis_Homo sapiens_hsa041440.48750349
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42679572
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41790992
147Chemokine signaling pathway_Homo sapiens_hsa040620.41126632
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41000228
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40479858
150Endometrial cancer_Homo sapiens_hsa052130.40164152
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39712809
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37981455
153Wnt signaling pathway_Homo sapiens_hsa043100.37464206
154Prion diseases_Homo sapiens_hsa050200.36135512
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35967007
156Insulin signaling pathway_Homo sapiens_hsa049100.35150813
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.33534242
158Renal cell carcinoma_Homo sapiens_hsa052110.32802646
159Fatty acid biosynthesis_Homo sapiens_hsa000610.31912018
160African trypanosomiasis_Homo sapiens_hsa051430.29297759
161Platelet activation_Homo sapiens_hsa046110.26176532
162Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22766000
163Tight junction_Homo sapiens_hsa045300.22655661
164Mineral absorption_Homo sapiens_hsa049780.22026945

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