TRAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational fidelity (GO:0006450)5.39384449
2lysine catabolic process (GO:0006554)5.21131513
3lysine metabolic process (GO:0006553)5.21131513
4nuclear pore complex assembly (GO:0051292)4.95406642
5L-phenylalanine metabolic process (GO:0006558)4.89433095
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.89433095
7L-phenylalanine catabolic process (GO:0006559)4.83376544
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.83376544
9DNA strand elongation (GO:0022616)4.80682110
10glycine metabolic process (GO:0006544)4.75178894
11glyoxylate metabolic process (GO:0046487)4.71476173
12mitotic chromosome condensation (GO:0007076)4.62668317
13proline biosynthetic process (GO:0006561)4.55870181
14serine family amino acid biosynthetic process (GO:0009070)4.52574271
15formation of translation preinitiation complex (GO:0001731)4.47953190
16aromatic amino acid family catabolic process (GO:0009074)4.45464286
17nuclear pore organization (GO:0006999)4.45204203
18DNA replication initiation (GO:0006270)4.38423150
19peptidyl-arginine omega-N-methylation (GO:0035247)4.35522630
20telomere maintenance via semi-conservative replication (GO:0032201)4.33224000
21kynurenine metabolic process (GO:0070189)4.29790438
22serine family amino acid catabolic process (GO:0009071)4.24886186
23cysteine metabolic process (GO:0006534)4.24266694
24serine family amino acid metabolic process (GO:0009069)4.19108819
25amino-acid betaine metabolic process (GO:0006577)4.16099840
26tryptophan catabolic process (GO:0006569)4.13412949
27indole-containing compound catabolic process (GO:0042436)4.13412949
28indolalkylamine catabolic process (GO:0046218)4.13412949
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.12003821
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.05631894
31valine metabolic process (GO:0006573)4.05488662
32sulfur amino acid catabolic process (GO:0000098)4.05402777
33alpha-linolenic acid metabolic process (GO:0036109)4.04400718
34mitotic sister chromatid segregation (GO:0000070)4.02943778
352-oxoglutarate metabolic process (GO:0006103)4.00673946
36L-serine metabolic process (GO:0006563)3.92804213
37tryptophan metabolic process (GO:0006568)3.88395710
38bile acid biosynthetic process (GO:0006699)3.87526004
39aspartate family amino acid catabolic process (GO:0009068)3.83785453
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.81508519
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.77681690
42ethanol oxidation (GO:0006069)3.76811973
43homocysteine metabolic process (GO:0050667)3.75791841
44fatty acid beta-oxidation (GO:0006635)3.74738348
45pore complex assembly (GO:0046931)3.72798877
46acetyl-CoA metabolic process (GO:0006084)3.70856888
47mitotic nuclear envelope disassembly (GO:0007077)3.69948506
48establishment of integrated proviral latency (GO:0075713)3.69413624
49sister chromatid segregation (GO:0000819)3.67253117
50regulation of triglyceride catabolic process (GO:0010896)3.67151509
51histone arginine methylation (GO:0034969)3.67042631
52alpha-amino acid catabolic process (GO:1901606)3.66748836
53urea metabolic process (GO:0019627)3.65950489
54urea cycle (GO:0000050)3.65950489
55COPI coating of Golgi vesicle (GO:0048205)3.65776245
56Golgi transport vesicle coating (GO:0048200)3.65776245
57folic acid-containing compound biosynthetic process (GO:0009396)3.64911323
58branched-chain amino acid catabolic process (GO:0009083)3.63873019
59carnitine metabolic process (GO:0009437)3.63716168
60peptidyl-arginine methylation (GO:0018216)3.63313062
61peptidyl-arginine N-methylation (GO:0035246)3.63313062
62tricarboxylic acid cycle (GO:0006099)3.61428639
63tRNA aminoacylation for protein translation (GO:0006418)3.59411988
64DNA replication checkpoint (GO:0000076)3.58346141
65oxaloacetate metabolic process (GO:0006107)3.56208859
66ribosome assembly (GO:0042255)3.55674413
67telomere maintenance via recombination (GO:0000722)3.52443991
68ribosome biogenesis (GO:0042254)3.52091066
69tetrahydrofolate metabolic process (GO:0046653)3.49820784
70short-chain fatty acid metabolic process (GO:0046459)3.49662780
71protein complex localization (GO:0031503)3.47980450
72tRNA aminoacylation (GO:0043039)3.47288188
73amino acid activation (GO:0043038)3.47288188
74branched-chain amino acid metabolic process (GO:0009081)3.47111029
75viral mRNA export from host cell nucleus (GO:0046784)3.46794984
76nuclear envelope disassembly (GO:0051081)3.46501723
77membrane disassembly (GO:0030397)3.46501723
78negative regulation of fibrinolysis (GO:0051918)3.46160095
79ribosomal small subunit biogenesis (GO:0042274)3.45366574
80cellular amino acid catabolic process (GO:0009063)3.44149474
81fatty acid oxidation (GO:0019395)3.44100552
82tricarboxylic acid metabolic process (GO:0072350)3.43809414
83negative regulation of mRNA processing (GO:0050686)3.43151484
84nucleobase-containing small molecule interconversion (GO:0015949)3.41265165
85nucleobase biosynthetic process (GO:0046112)3.38697643
86nitrogen cycle metabolic process (GO:0071941)3.38561169
87protein localization to chromosome, centromeric region (GO:0071459)3.38230504
88folic acid metabolic process (GO:0046655)3.37260011
89lipid oxidation (GO:0034440)3.34384696
90regulation of mitochondrial translation (GO:0070129)3.33980920
91DNA topological change (GO:0006265)3.33281761
92ribonucleoprotein complex biogenesis (GO:0022613)3.32922863
93DNA duplex unwinding (GO:0032508)3.31988196
94fatty acid catabolic process (GO:0009062)3.31243024
95regulation of translational elongation (GO:0006448)3.29280676
96imidazole-containing compound metabolic process (GO:0052803)3.28598823
97aromatic amino acid family metabolic process (GO:0009072)3.28504228
98mitotic recombination (GO:0006312)3.28422849
99maturation of SSU-rRNA (GO:0030490)3.28013500
100proline metabolic process (GO:0006560)3.25323248
101purine nucleobase biosynthetic process (GO:0009113)3.24799918
102regulation of protein activation cascade (GO:2000257)3.22579954
103one-carbon metabolic process (GO:0006730)3.22009728
104heterochromatin organization (GO:0070828)3.21984156
105IMP biosynthetic process (GO:0006188)3.21560131
106protein localization to kinetochore (GO:0034501)3.20117605
107organic acid catabolic process (GO:0016054)3.19461124
108carboxylic acid catabolic process (GO:0046395)3.19461124
109complement activation, alternative pathway (GO:0006957)3.18162149
110bile acid metabolic process (GO:0008206)3.18066688
111monocarboxylic acid catabolic process (GO:0072329)3.17850799
112DNA geometric change (GO:0032392)3.15770856
113rRNA transcription (GO:0009303)3.12746457
114cellular ketone body metabolic process (GO:0046950)3.12705933
115negative regulation of RNA splicing (GO:0033119)3.12028797
116negative regulation of fatty acid biosynthetic process (GO:0045717)3.11230500
117negative regulation of mRNA metabolic process (GO:1903312)3.10707400
118high-density lipoprotein particle remodeling (GO:0034375)3.10645050
119urate metabolic process (GO:0046415)3.08758669
120mitotic metaphase plate congression (GO:0007080)3.08758062
121aldehyde catabolic process (GO:0046185)3.08011181
122cellular protein complex localization (GO:0034629)3.06014304
123regulation of translational termination (GO:0006449)3.05628264
124chromosome condensation (GO:0030261)3.04484795
125NADH metabolic process (GO:0006734)3.03690786
126biotin metabolic process (GO:0006768)3.03383966
127regulation of fibrinolysis (GO:0051917)3.03304303
128regulation of complement activation (GO:0030449)3.02305155
129ribosomal large subunit biogenesis (GO:0042273)3.01803950
130aspartate family amino acid metabolic process (GO:0009066)3.01704056
131cellular modified amino acid catabolic process (GO:0042219)3.01463131
132dicarboxylic acid biosynthetic process (GO:0043650)3.01305114
133folic acid-containing compound metabolic process (GO:0006760)2.99776306
134DNA unwinding involved in DNA replication (GO:0006268)2.98810300
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98793465
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.98336434
137drug transmembrane transport (GO:0006855)2.97445192
138IMP metabolic process (GO:0046040)2.97227357
139fatty acid transmembrane transport (GO:1902001)2.96972112
140dicarboxylic acid metabolic process (GO:0043648)2.96954532
141DNA conformation change (GO:0071103)2.96543035
142protein carboxylation (GO:0018214)2.96410870
143peptidyl-glutamic acid carboxylation (GO:0017187)2.96410870
144protein-DNA complex disassembly (GO:0032986)2.95326483
145nucleosome disassembly (GO:0006337)2.95326483
146regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94468602
147negative regulation of cholesterol transport (GO:0032375)2.93106628
148negative regulation of sterol transport (GO:0032372)2.93106628
149establishment of viral latency (GO:0019043)2.91700146
150regulation of mitotic spindle organization (GO:0060236)2.90655336
151glutamate metabolic process (GO:0006536)2.90609168
152nuclear envelope organization (GO:0006998)2.89076645
153oxidative phosphorylation (GO:0006119)2.89027925
154triglyceride homeostasis (GO:0070328)2.88692012
155acylglycerol homeostasis (GO:0055090)2.88692012
156benzene-containing compound metabolic process (GO:0042537)2.87407658
157succinate metabolic process (GO:0006105)2.87341530
158pteridine-containing compound biosynthetic process (GO:0042559)2.86640369
159pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85230912
160carnitine shuttle (GO:0006853)2.85060418
161telomere maintenance via telomere lengthening (GO:0010833)2.84363875
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84292574
163tyrosine metabolic process (GO:0006570)2.82391673
164coenzyme catabolic process (GO:0009109)2.82377986
165regulation of RNA export from nucleus (GO:0046831)2.82104101
166DNA strand elongation involved in DNA replication (GO:0006271)2.80955874
167pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.80801343
168mitotic sister chromatid cohesion (GO:0007064)2.79540158
169indolalkylamine metabolic process (GO:0006586)2.79298969
170sulfur amino acid metabolic process (GO:0000096)2.79292118
171plasma lipoprotein particle clearance (GO:0034381)2.78227998
172protein maturation by protein folding (GO:0022417)2.77685561
173pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.77357251
174glycolytic process (GO:0006096)2.76426331
175gluconeogenesis (GO:0006094)2.75826096
176base-excision repair (GO:0006284)2.74745281
177positive regulation of chromosome segregation (GO:0051984)2.73948496
178mitochondrial RNA metabolic process (GO:0000959)2.73726425
179pentose-phosphate shunt (GO:0006098)2.73690220
180transcription from mitochondrial promoter (GO:0006390)2.72555031
181mitochondrial fusion (GO:0008053)2.71774174
182protein export from nucleus (GO:0006611)2.71260374
183non-recombinational repair (GO:0000726)2.69639847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.16983635
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.67652886
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.24274732
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.64401763
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56040305
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.47405526
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.29280379
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.96910483
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.89304729
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.59643523
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.56485274
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31445529
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31066171
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.24614140
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22680056
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13038282
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12578494
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10475478
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02413763
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01239231
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.01214030
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95871375
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.91230385
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.90765256
25AR_21909140_ChIP-Seq_LNCAP_Human1.90431889
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85593453
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.81737812
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76878628
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73412509
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71211787
31* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70757776
32XRN2_22483619_ChIP-Seq_HELA_Human1.68960671
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.66872885
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66486165
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60937496
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60058835
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56429969
38FOXP3_21729870_ChIP-Seq_TREG_Human1.52462558
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49546083
40DCP1A_22483619_ChIP-Seq_HELA_Human1.49326850
41* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.46852867
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46698719
43* SRF_21415370_ChIP-Seq_HL-1_Mouse1.46176539
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43766492
45* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40869806
46VDR_23849224_ChIP-Seq_CD4+_Human1.39539230
47* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38588766
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38031369
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37805327
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37567957
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35664069
52CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35544382
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.34960065
54GABP_19822575_ChIP-Seq_HepG2_Human1.33394172
55MYC_22102868_ChIP-Seq_BL_Human1.33315494
56* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33195969
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29658652
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28964087
59* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23712148
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21466284
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21451634
62* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20999688
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20224168
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20140564
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19207385
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18743195
67RACK7_27058665_Chip-Seq_MCF-7_Human1.18086204
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17925786
69LXR_22292898_ChIP-Seq_THP-1_Human1.17863383
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17160220
71KDM5A_27292631_Chip-Seq_BREAST_Human1.16461068
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15687784
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.15531484
74GATA1_22025678_ChIP-Seq_K562_Human1.14534864
75CIITA_25753668_ChIP-Seq_RAJI_Human1.14347904
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.13551643
77CLOCK_20551151_ChIP-Seq_293T_Human1.12010130
78* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11250457
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09626887
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.09528512
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08757773
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08178512
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07174357
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06536187
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06147922
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06006534
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05517531
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05392791
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04379860
90* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03681470
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03147883
92TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02834427
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02543526
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02210795
95ZNF263_19887448_ChIP-Seq_K562_Human1.02073296
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98832213
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.98453486
98P68_20966046_ChIP-Seq_HELA_Human0.97801898
99* CHD1_26751641_Chip-Seq_LNCaP_Human0.97330241
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.96323413
101TTF2_22483619_ChIP-Seq_HELA_Human0.96097641
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95980407
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95034417
104EGR1_19374776_ChIP-ChIP_THP-1_Human0.94178503
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94111699
106ATF3_27146783_Chip-Seq_COLON_Human0.94096917
107NCOR1_26117541_ChIP-Seq_K562_Human0.93951929
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93411809
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92504095
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91531669
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90684114
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90021614
113SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89834601
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89095425
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88560523
116* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88076825
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87656556
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86213545
119TFEB_21752829_ChIP-Seq_HELA_Human0.85261894
120VDR_21846776_ChIP-Seq_THP-1_Human0.84529831
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84277892
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82013078
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81556771
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79079364
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78731349
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78695793
127* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76743067
128ELK1_19687146_ChIP-ChIP_HELA_Human0.75746531
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74471089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.82191699
2MP0002139_abnormal_hepatobiliary_system5.77749903
3MP0003806_abnormal_nucleotide_metabolis5.04178899
4MP0005085_abnormal_gallbladder_physiolo4.56328160
5MP0005365_abnormal_bile_salt4.43693020
6MP0008875_abnormal_xenobiotic_pharmacok3.41929390
7MP0004233_abnormal_muscle_weight2.68271854
8MP0010329_abnormal_lipoprotein_level2.60082396
9MP0005332_abnormal_amino_acid2.57726611
10MP0003252_abnormal_bile_duct2.51341124
11MP0009840_abnormal_foam_cell2.22257142
12MP0010234_abnormal_vibrissa_follicle2.10879910
13MP0005083_abnormal_biliary_tract2.07869613
14MP0006036_abnormal_mitochondrial_physio2.07571414
15MP0003186_abnormal_redox_activity2.04734781
16MP0010094_abnormal_chromosome_stability1.93582687
17MP0003693_abnormal_embryo_hatching1.88732999
18MP0005319_abnormal_enzyme/_coenzyme1.84390078
19MP0001764_abnormal_homeostasis1.83679631
20MP0002877_abnormal_melanocyte_morpholog1.82139844
21MP0000609_abnormal_liver_physiology1.81667959
22MP0005670_abnormal_white_adipose1.80462327
23MP0001666_abnormal_nutrient_absorption1.76332350
24MP0000537_abnormal_urethra_morphology1.74797215
25MP0004957_abnormal_blastocyst_morpholog1.74448892
26MP0003195_calcinosis1.70424390
27MP0005076_abnormal_cell_differentiation1.69702589
28MP0003111_abnormal_nucleus_morphology1.67867409
29MP0010030_abnormal_orbit_morphology1.63056407
30MP0003123_paternal_imprinting1.60361919
31MP0004019_abnormal_vitamin_homeostasis1.59205049
32MP0003191_abnormal_cellular_cholesterol1.58586232
33MP0000678_abnormal_parathyroid_gland1.57001938
34MP0000566_synostosis1.56483034
35MP0002118_abnormal_lipid_homeostasis1.55387238
36MP0005501_abnormal_skin_physiology1.53153125
37MP0005584_abnormal_enzyme/coenzyme_acti1.47296520
38MP0009643_abnormal_urine_homeostasis1.45081638
39MP0000313_abnormal_cell_death1.43597899
40MP0002396_abnormal_hematopoietic_system1.42253447
41MP0003077_abnormal_cell_cycle1.42200240
42MP0003705_abnormal_hypodermis_morpholog1.41227965
43MP0002796_impaired_skin_barrier1.40644323
44MP0009697_abnormal_copulation1.40578476
45MP0002085_abnormal_embryonic_tissue1.39869249
46MP0003656_abnormal_erythrocyte_physiolo1.39105278
47MP0008057_abnormal_DNA_replication1.37454699
48MP0003315_abnormal_perineum_morphology1.36630288
49MP0001346_abnormal_lacrimal_gland1.33984358
50MP0000598_abnormal_liver_morphology1.32836801
51MP0002084_abnormal_developmental_patter1.31707045
52MP0005266_abnormal_metabolism1.30530980
53MP0004147_increased_porphyrin_level1.29524332
54MP0004858_abnormal_nervous_system1.28782111
55MP0002837_dystrophic_cardiac_calcinosis1.28383428
56MP0006035_abnormal_mitochondrial_morpho1.27463881
57MP0000747_muscle_weakness1.25734786
58MP0004084_abnormal_cardiac_muscle1.22786121
59MP0005666_abnormal_adipose_tissue1.21946078
60MP0000751_myopathy1.21575039
61MP0000003_abnormal_adipose_tissue1.21130642
62MP0002249_abnormal_larynx_morphology1.21074687
63MP0004130_abnormal_muscle_cell1.19877564
64MP0003646_muscle_fatigue1.19192753
65MP0001849_ear_inflammation1.16392103
66MP0010352_gastrointestinal_tract_polyps1.14368288
67MP0008058_abnormal_DNA_repair1.11190316
68MP0001730_embryonic_growth_arrest1.10243371
69MP0002269_muscular_atrophy1.09426825
70MP0005330_cardiomyopathy1.05007759
71MP0003221_abnormal_cardiomyocyte_apopto1.02323349
72MP0001727_abnormal_embryo_implantation1.01929466
73MP0002697_abnormal_eye_size0.99943199
74MP0005623_abnormal_meninges_morphology0.99605633
75MP0002138_abnormal_hepatobiliary_system0.98731515
76MP0000759_abnormal_skeletal_muscle0.97313521
77MP0005376_homeostasis/metabolism_phenot0.96625629
78MP0008260_abnormal_autophagy0.94738061
79MP0009763_increased_sensitivity_to0.93423076
80MP0008007_abnormal_cellular_replicative0.92662805
81MP0000579_abnormal_nail_morphology0.92052134
82MP0004264_abnormal_extraembryonic_tissu0.91219900
83MP0005636_abnormal_mineral_homeostasis0.90099756
84MP0005384_cellular_phenotype0.88036404
85MP0003941_abnormal_skin_development0.84885632
86MP0003937_abnormal_limbs/digits/tail_de0.83592420
87MP0005375_adipose_tissue_phenotype0.82478514
88MP0000749_muscle_degeneration0.81806744
89MP0002089_abnormal_postnatal_growth/wei0.81764850
90MP0003942_abnormal_urinary_system0.81563081
91MP0005621_abnormal_cell_physiology0.79430745
92MP0001529_abnormal_vocalization0.79223096
93MP0004036_abnormal_muscle_relaxation0.79004681
94MP0009672_abnormal_birth_weight0.78439134
95MP0002970_abnormal_white_adipose0.76886314
96MP0003984_embryonic_growth_retardation0.76871448
97MP0003567_abnormal_fetal_cardiomyocyte0.76038956
98MP0002111_abnormal_tail_morphology0.75838037
99MP0002088_abnormal_embryonic_growth/wei0.75565570
100MP0009703_decreased_birth_body0.75066387
101MP0003385_abnormal_body_wall0.74964813
102MP0002971_abnormal_brown_adipose0.74761432
103MP0010307_abnormal_tumor_latency0.74605097
104MP0002210_abnormal_sex_determination0.74497852
105MP0001672_abnormal_embryogenesis/_devel0.74390115
106MP0005380_embryogenesis_phenotype0.74390115
107MP0001348_abnormal_lacrimal_gland0.73871757
108MP0005647_abnormal_sex_gland0.73767050
109MP0001756_abnormal_urination0.73175346
110MP0004782_abnormal_surfactant_physiolog0.72881519
111MP0003868_abnormal_feces_composition0.72505620
112MP0008469_abnormal_protein_level0.72315970
113MP0000733_abnormal_muscle_development0.72294500
114MP0001661_extended_life_span0.72104484
115MP0002163_abnormal_gland_morphology0.71816494
116MP0000358_abnormal_cell_content/0.71530975
117MP0003566_abnormal_cell_adhesion0.70927621
118MP0002098_abnormal_vibrissa_morphology0.70738976
119MP0003861_abnormal_nervous_system0.70449429
120MP0010630_abnormal_cardiac_muscle0.70347109
121MP0002080_prenatal_lethality0.69772668
122MP0003718_maternal_effect0.69246886
123MP0002019_abnormal_tumor_incidence0.69191424
124MP0005397_hematopoietic_system_phenotyp0.68594503
125MP0001545_abnormal_hematopoietic_system0.68594503
126MP0000350_abnormal_cell_proliferation0.68000799
127MP0005451_abnormal_body_composition0.67991439
128MP0001853_heart_inflammation0.67765161
129MP0000750_abnormal_muscle_regeneration0.67384633
130MP0000467_abnormal_esophagus_morphology0.67360125
131MP0009642_abnormal_blood_homeostasis0.67296103
132MP0004087_abnormal_muscle_fiber0.67273328
133MP0003115_abnormal_respiratory_system0.66906284
134MP0002136_abnormal_kidney_physiology0.66108063
135MP0005385_cardiovascular_system_phenoty0.65667658
136MP0001544_abnormal_cardiovascular_syste0.65667658
137MP0001881_abnormal_mammary_gland0.65167425
138MP0003786_premature_aging0.64922260
139MP0004197_abnormal_fetal_growth/weight/0.64868715
140MP0008932_abnormal_embryonic_tissue0.63787810
141MP0002086_abnormal_extraembryonic_tissu0.63520262
142MP0000762_abnormal_tongue_morphology0.63187419
143MP0002092_abnormal_eye_morphology0.62780010
144MP0005023_abnormal_wound_healing0.62739056
145MP0001697_abnormal_embryo_size0.62168767
146MP0008995_early_reproductive_senescence0.62143072
147MP0004185_abnormal_adipocyte_glucose0.61756915
148MP0006054_spinal_hemorrhage0.61483865
149MP0005408_hypopigmentation0.60973993
150MP0009053_abnormal_anal_canal0.60517491
151MP0009765_abnormal_xenobiotic_induced0.59334704
152MP0002078_abnormal_glucose_homeostasis0.59157817
153MP0000490_abnormal_crypts_of0.57881281
154MP0002132_abnormal_respiratory_system0.57056940
155MP0005334_abnormal_fat_pad0.56143072

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.03460023
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.79790331
3Hypobetalipoproteinemia (HP:0003563)4.77610090
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.73493767
5Hyperglycinuria (HP:0003108)4.72083735
6Hyperammonemia (HP:0001987)4.68380261
7Abnormality of serine family amino acid metabolism (HP:0010894)4.40841449
8Abnormality of glycine metabolism (HP:0010895)4.40841449
9Deep venous thrombosis (HP:0002625)4.30888165
10Hyperglycinemia (HP:0002154)4.30550824
11Abnormality of fatty-acid metabolism (HP:0004359)4.18564835
12Hypoglycemic coma (HP:0001325)4.13748999
13Ketosis (HP:0001946)4.06552075
14Xanthomatosis (HP:0000991)4.02975858
15Abnormality of pyrimidine metabolism (HP:0004353)3.78517275
16Progressive muscle weakness (HP:0003323)3.73076220
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69257740
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.68922996
19Dicarboxylic aciduria (HP:0003215)3.68922996
20Microvesicular hepatic steatosis (HP:0001414)3.59478273
21Chromsome breakage (HP:0040012)3.57715324
22Hypolipoproteinemia (HP:0010981)3.57445013
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.45585407
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.44737902
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36674977
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32666387
27Abnormality of serum amino acid levels (HP:0003112)3.27256267
28Ketoacidosis (HP:0001993)3.27074019
29Abnormality of methionine metabolism (HP:0010901)3.26046265
30Prolonged partial thromboplastin time (HP:0003645)3.25048961
31Rhabdomyolysis (HP:0003201)3.23923585
32Hyperlipoproteinemia (HP:0010980)3.23583266
33Generalized aminoaciduria (HP:0002909)3.21570837
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.21235073
35Hyperacusis (HP:0010780)3.14411327
36Myoglobinuria (HP:0002913)3.11920869
37Cerebral edema (HP:0002181)3.04990921
38Abnormality of nucleobase metabolism (HP:0010932)3.02784997
39Insomnia (HP:0100785)3.02023114
40Lethargy (HP:0001254)3.00308209
41Hepatic necrosis (HP:0002605)2.99832099
42Hypoalphalipoproteinemia (HP:0003233)2.94612071
43Hyperbilirubinemia (HP:0002904)2.93954715
44Complement deficiency (HP:0004431)2.90693013
45Metabolic acidosis (HP:0001942)2.87850471
46Nausea (HP:0002018)2.86193183
47Increased nuchal translucency (HP:0010880)2.85669124
48Spastic diplegia (HP:0001264)2.83996399
49Trismus (HP:0000211)2.80632032
50Delayed CNS myelination (HP:0002188)2.78572432
51Reticulocytopenia (HP:0001896)2.71816336
52Proximal tubulopathy (HP:0000114)2.70913854
53Fat malabsorption (HP:0002630)2.70857956
54Gout (HP:0001997)2.68028759
55Epidermoid cyst (HP:0200040)2.66579262
56Abnormality of purine metabolism (HP:0004352)2.64918858
57Abnormality of reticulocytes (HP:0004312)2.60713853
58Abnormality of the common coagulation pathway (HP:0010990)2.57392265
59Birth length less than 3rd percentile (HP:0003561)2.57137110
60Abnormality of glycolysis (HP:0004366)2.54279678
61Increased serum pyruvate (HP:0003542)2.54279678
62Joint hemorrhage (HP:0005261)2.46382354
63Selective tooth agenesis (HP:0001592)2.45542357
64Proximal placement of thumb (HP:0009623)2.43700995
65Progressive external ophthalmoplegia (HP:0000590)2.42122516
66Hepatocellular carcinoma (HP:0001402)2.40476916
67Multiple enchondromatosis (HP:0005701)2.40178616
68Abnormality of cells of the erythroid lineage (HP:0012130)2.38014591
69Septate vagina (HP:0001153)2.37743751
70Vomiting (HP:0002013)2.37005834
71Dysmetric saccades (HP:0000641)2.36791428
72Oral leukoplakia (HP:0002745)2.34476920
73Abnormality of the intrinsic pathway (HP:0010989)2.31398241
74Renal cortical cysts (HP:0000803)2.31287083
75Myopathic facies (HP:0002058)2.30365823
76Deviation of the thumb (HP:0009603)2.30297948
77Increased muscle lipid content (HP:0009058)2.29543629
78Ragged-red muscle fibers (HP:0003200)2.28752722
79Hepatocellular necrosis (HP:0001404)2.25393754
80Hypercholesterolemia (HP:0003124)2.23854944
81Increased purine levels (HP:0004368)2.22761667
82Hyperuricemia (HP:0002149)2.22761667
83Acute encephalopathy (HP:0006846)2.21802693
84Cholelithiasis (HP:0001081)2.21342168
85Truncus arteriosus (HP:0001660)2.18997893
86Lactic acidosis (HP:0003128)2.16456133
87Abnormality of complement system (HP:0005339)2.14215445
88Broad distal phalanx of finger (HP:0009836)2.13597220
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.13342850
90Overriding aorta (HP:0002623)2.12787677
91Calcaneovalgus deformity (HP:0001848)2.12566363
92Achilles tendon contracture (HP:0001771)2.10044596
93Steatorrhea (HP:0002570)2.09372744
94Abnormal cartilage morphology (HP:0002763)2.07574740
95Abnormal number of erythroid precursors (HP:0012131)2.07319318
96Increased serum lactate (HP:0002151)2.07212069
97Abnormality of the calcaneus (HP:0008364)2.05826595
98Exercise-induced muscle cramps (HP:0003710)2.05707943
99Abnormal gallbladder morphology (HP:0012437)2.05649912
100Abnormality of cochlea (HP:0000375)2.05211336
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04618605
102Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04618605
103Abnormality of the preputium (HP:0100587)2.04527493
104Increased connective tissue (HP:0009025)2.04440516
105Squamous cell carcinoma (HP:0002860)2.01961680
106Testicular atrophy (HP:0000029)2.00866970
107Overlapping toe (HP:0001845)1.99124999
108Limb hypertonia (HP:0002509)1.97715475
109Hypertriglyceridemia (HP:0002155)1.97304777
110Cortical dysplasia (HP:0002539)1.97272728
111Neonatal onset (HP:0003623)1.96719434
112Late onset (HP:0003584)1.96031497
113Glycosuria (HP:0003076)1.95714151
114Abnormality of urine glucose concentration (HP:0011016)1.95714151
115Opisthotonus (HP:0002179)1.93862012
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93469422
117Methylmalonic aciduria (HP:0012120)1.92589966
118Elfin facies (HP:0004428)1.91768665
119CNS demyelination (HP:0007305)1.90729612
120Deformed tarsal bones (HP:0008119)1.90440037
121Abnormality of the gallbladder (HP:0005264)1.90123677
122High anterior hairline (HP:0009890)1.89068787
123Abnormality of the Achilles tendon (HP:0005109)1.86708584
124Facial cleft (HP:0002006)1.85985750
125Cholecystitis (HP:0001082)1.85239447
126Abnormal gallbladder physiology (HP:0012438)1.85239447
127Elevated hepatic transaminases (HP:0002910)1.84316460
128Pancreatitis (HP:0001733)1.82450185
129Megaloblastic anemia (HP:0001889)1.82145609
130Ulnar bowing (HP:0003031)1.81603270
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.81459315
132Microglossia (HP:0000171)1.80423366
133Atresia of the external auditory canal (HP:0000413)1.79917772
134Abnormality of iron homeostasis (HP:0011031)1.79896720
135Increased CSF lactate (HP:0002490)1.79802498
136Abnormality of transition element cation homeostasis (HP:0011030)1.79739389
137Abnormality of the umbilical cord (HP:0010881)1.79577588
138Poikilocytosis (HP:0004447)1.78645213
139Brushfield spots (HP:0001088)1.77865756
140Skin nodule (HP:0200036)1.76518647
141Reticulocytosis (HP:0001923)1.76401579
142Distal lower limb amyotrophy (HP:0008944)1.75452421
143Premature ovarian failure (HP:0008209)1.75014665
144Glossoptosis (HP:0000162)1.74628903
145Unilateral renal agenesis (HP:0000122)1.74208536
146Horseshoe kidney (HP:0000085)1.74126909
147Acanthocytosis (HP:0001927)1.73931612
148Long palpebral fissure (HP:0000637)1.73534696
149Abnormality of alanine metabolism (HP:0010916)1.73111804
150Hyperalaninemia (HP:0003348)1.73111804
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73111804
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72694628
153Secondary amenorrhea (HP:0000869)1.71079242
154Urethral obstruction (HP:0000796)1.70859594
155Sparse lateral eyebrow (HP:0005338)1.70805617
156Exercise-induced myalgia (HP:0003738)1.70787696
157Renal duplication (HP:0000075)1.69694557
158Patellar dislocation (HP:0002999)1.67510597
159Premature skin wrinkling (HP:0100678)1.65136645
160Meckel diverticulum (HP:0002245)1.64509003
161Self-mutilation (HP:0000742)1.63622937
162Choanal atresia (HP:0000453)1.63469950
163Preauricular skin tag (HP:0000384)1.62789025
164Hypoparathyroidism (HP:0000829)1.61867292
165Hyperthyroidism (HP:0000836)1.61084459
166Pointed chin (HP:0000307)1.60761912
167Upper limb amyotrophy (HP:0009129)1.60655050
168Distal upper limb amyotrophy (HP:0007149)1.60655050
169Ankyloglossia (HP:0010296)1.60575197
170Macrocytic anemia (HP:0001972)1.60527520
171Breast hypoplasia (HP:0003187)1.60121285
172Upper limb muscle weakness (HP:0003484)1.59987360
173Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57989836
174Absent epiphyses (HP:0010577)1.57989836
175Pseudobulbar signs (HP:0002200)1.57734351
176Abnormality of the salivary glands (HP:0010286)1.57642478
177Orthostatic hypotension (HP:0001278)1.56946227
178Breech presentation (HP:0001623)1.56306020
179Abnormal number of incisors (HP:0011064)1.55245939
180Exercise intolerance (HP:0003546)1.55225792
181Rough bone trabeculation (HP:0100670)1.54541967
182Abnormality of the tricuspid valve (HP:0001702)1.54472334
183Abnormality of the carotid arteries (HP:0005344)1.53566636
184Abnormality of the ileum (HP:0001549)1.53065893
185Cafe-au-lait spot (HP:0000957)1.52314700
186Abnormalities of placenta or umbilical cord (HP:0001194)1.51897438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.34712543
2NEK13.59538857
3SMG13.56896476
4PKN23.01102479
5BUB12.71641718
6PDK32.60818177
7PDK42.60818177
8WEE12.55162253
9FLT32.51481552
10CDC72.38247606
11EIF2AK12.34553273
12TRIB32.17607662
13MAP2K32.12586470
14IRAK32.04934773
15VRK21.98512647
16TSSK61.96670287
17NME21.96522921
18EEF2K1.85696418
19PBK1.78707713
20ERN11.69460240
21PIK3CG1.67760216
22FGFR41.66069442
23NME11.61423704
24MST1R1.57402180
25TTK1.57346744
26NEK21.56320623
27RPS6KB21.55867094
28SIK11.51721603
29TTN1.50643883
30CDK41.43126537
31MAP3K101.36762083
32PDK21.34524500
33TGFBR11.26442602
34MAPK111.23885257
35KDR1.23656209
36EIF2AK31.21961737
37PASK1.21805859
38NEK91.18877449
39ARAF1.18439160
40ACVR1B1.17933884
41SCYL21.15835896
42ATR1.14973920
43MAP4K11.12033589
44MAP3K31.06971717
45BRAF1.06704685
46AURKB1.05969073
47PLK11.05702163
48STK41.05119826
49MAP3K81.03355833
50CDK71.02240937
51CDK81.01620825
52BRSK21.01137129
53OBSCN1.00023296
54PRPF4B0.99768401
55CDK120.99743506
56STK160.98757464
57LRRK20.95758106
58STK100.93881653
59TIE10.92987644
60MAPKAPK30.92153090
61SRPK10.91535563
62TESK20.91148249
63KSR20.86642163
64EPHA20.81569632
65ALK0.78414179
66CDK60.77923636
67CDK10.75639776
68LATS20.74886068
69MAP3K90.74786199
70STK38L0.74718213
71PAK40.74403130
72MYLK0.72828628
73PRKD30.72164632
74CLK10.70466350
75MAP2K60.68875748
76CCNB10.67719340
77KIT0.66086535
78PLK40.65472554
79MAP3K110.65454887
80RAF10.65286265
81DAPK10.64838056
82AURKA0.64127839
83PIM10.62638317
84MTOR0.62078261
85MET0.61119990
86GRK60.60128302
87CHEK10.58497163
88ZAK0.57961062
89CDK11A0.57776323
90VRK10.57539916
91BRD40.56949419
92PINK10.56545344
93TLK10.54366932
94CDK150.54079609
95CSNK2A20.53968444
96TYK20.53790950
97TAF10.53667169
98CAMK1D0.53221979
99RPS6KA40.53098808
100ABL20.52904145
101ERBB40.52330087
102MAPKAPK50.52287644
103PTK60.51901210
104CDK180.50406066
105BRSK10.49229739
106CSNK1E0.48863161
107PRKCI0.47822418
108CDK90.47710910
109BTK0.46397151
110CSF1R0.45142257
111CSNK2A10.44209274
112CDK140.43028112
113TAOK20.42560601
114PHKG10.42113892
115PHKG20.42113892
116ATM0.41513891
117ILK0.41262001
118ZAP700.41117680
119PAK10.40783083
120CDK20.40409161
121PRKDC0.40289192
122CHEK20.39930740
123AKT20.39895830
124EIF2AK20.39512995
125CSNK1G30.39035996
126TESK10.37659817
127RPS6KA60.37033476
128PIM20.36229928
129RPS6KB10.35900350
130RPS6KL10.35871479
131RPS6KC10.35871479
132CSNK1A1L0.35723502
133MAP3K70.34210709
134MAPK140.33807510
135FGFR10.33045732
136PLK30.31764080
137ICK0.30844055
138JAK30.30233350
139DYRK30.29164130

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.94666779
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.92924670
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.86910942
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81034091
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.65738503
6Propanoate metabolism_Homo sapiens_hsa006402.64774472
7Fatty acid degradation_Homo sapiens_hsa000712.63641223
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.57241767
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48768248
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33902530
11One carbon pool by folate_Homo sapiens_hsa006702.14748652
12Carbon metabolism_Homo sapiens_hsa012002.12641227
13Nitrogen metabolism_Homo sapiens_hsa009102.10490333
14Arginine biosynthesis_Homo sapiens_hsa002202.10257658
15Tryptophan metabolism_Homo sapiens_hsa003802.09298940
16Pyruvate metabolism_Homo sapiens_hsa006201.98549301
17Biosynthesis of amino acids_Homo sapiens_hsa012301.96258900
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96254853
19Fatty acid metabolism_Homo sapiens_hsa012121.90893953
20DNA replication_Homo sapiens_hsa030301.87066350
21Selenocompound metabolism_Homo sapiens_hsa004501.83715403
22Peroxisome_Homo sapiens_hsa041461.78869113
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.75627354
24Butanoate metabolism_Homo sapiens_hsa006501.75369609
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75295164
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.73668206
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.71320943
28beta-Alanine metabolism_Homo sapiens_hsa004101.61224357
29PPAR signaling pathway_Homo sapiens_hsa033201.55489741
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47711730
31mRNA surveillance pathway_Homo sapiens_hsa030151.47022864
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46912165
33Mismatch repair_Homo sapiens_hsa034301.46590394
34Caffeine metabolism_Homo sapiens_hsa002321.41765077
35Complement and coagulation cascades_Homo sapiens_hsa046101.39731629
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38992460
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35869457
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33571293
39Folate biosynthesis_Homo sapiens_hsa007901.30714151
40Pentose phosphate pathway_Homo sapiens_hsa000301.28466908
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26263634
42Chemical carcinogenesis_Homo sapiens_hsa052041.25367538
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24282427
44Sulfur relay system_Homo sapiens_hsa041221.18225639
45Phenylalanine metabolism_Homo sapiens_hsa003601.18126589
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15897651
47Fatty acid elongation_Homo sapiens_hsa000621.12183218
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11915604
49Starch and sucrose metabolism_Homo sapiens_hsa005001.10760993
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09517958
51Histidine metabolism_Homo sapiens_hsa003401.08262413
52Glutathione metabolism_Homo sapiens_hsa004801.02708497
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.00741740
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00570823
55Tyrosine metabolism_Homo sapiens_hsa003500.98315047
56Lysine degradation_Homo sapiens_hsa003100.96516791
57Base excision repair_Homo sapiens_hsa034100.96311019
58Proteasome_Homo sapiens_hsa030500.95925895
59Arginine and proline metabolism_Homo sapiens_hsa003300.95501965
60Retinol metabolism_Homo sapiens_hsa008300.95388041
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93132480
62Thyroid cancer_Homo sapiens_hsa052160.92603685
63Ribosome_Homo sapiens_hsa030100.91474680
64Pyrimidine metabolism_Homo sapiens_hsa002400.90149897
65Fat digestion and absorption_Homo sapiens_hsa049750.83372268
66N-Glycan biosynthesis_Homo sapiens_hsa005100.81455580
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80659806
68Vitamin B6 metabolism_Homo sapiens_hsa007500.80525973
69Fructose and mannose metabolism_Homo sapiens_hsa000510.78914536
70Sulfur metabolism_Homo sapiens_hsa009200.77792391
71Nucleotide excision repair_Homo sapiens_hsa034200.77376758
72Homologous recombination_Homo sapiens_hsa034400.75745338
73Bile secretion_Homo sapiens_hsa049760.73466792
74Bladder cancer_Homo sapiens_hsa052190.70940133
75RNA transport_Homo sapiens_hsa030130.70624096
76Galactose metabolism_Homo sapiens_hsa000520.68913664
77Oocyte meiosis_Homo sapiens_hsa041140.67373628
78Chronic myeloid leukemia_Homo sapiens_hsa052200.63359692
79Staphylococcus aureus infection_Homo sapiens_hsa051500.62835841
80Spliceosome_Homo sapiens_hsa030400.62728059
81Non-homologous end-joining_Homo sapiens_hsa034500.62159505
82Metabolic pathways_Homo sapiens_hsa011000.61383631
83Glycerolipid metabolism_Homo sapiens_hsa005610.61344874
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60018874
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59922630
86ABC transporters_Homo sapiens_hsa020100.59492090
87RNA polymerase_Homo sapiens_hsa030200.57023273
88Vitamin digestion and absorption_Homo sapiens_hsa049770.56699866
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54813792
90Viral carcinogenesis_Homo sapiens_hsa052030.53964573
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53597074
92Insulin signaling pathway_Homo sapiens_hsa049100.52615248
93Non-small cell lung cancer_Homo sapiens_hsa052230.50225601
94Fatty acid biosynthesis_Homo sapiens_hsa000610.47793768
95Basal transcription factors_Homo sapiens_hsa030220.45075485
96Prion diseases_Homo sapiens_hsa050200.43033427
97Cell cycle_Homo sapiens_hsa041100.42645868
98Alcoholism_Homo sapiens_hsa050340.39954142
99Epstein-Barr virus infection_Homo sapiens_hsa051690.39743581
100Parkinsons disease_Homo sapiens_hsa050120.35819223
101MicroRNAs in cancer_Homo sapiens_hsa052060.34575277
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34436312
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33694711
104RNA degradation_Homo sapiens_hsa030180.33239216
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33173301
106Vibrio cholerae infection_Homo sapiens_hsa051100.32863134
107Pancreatic cancer_Homo sapiens_hsa052120.31869081
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31345298
109mTOR signaling pathway_Homo sapiens_hsa041500.30265473
110Purine metabolism_Homo sapiens_hsa002300.30085264
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29775911
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29457420
113Endometrial cancer_Homo sapiens_hsa052130.28479902
114Systemic lupus erythematosus_Homo sapiens_hsa053220.28469538
115Steroid biosynthesis_Homo sapiens_hsa001000.26848568
116Glioma_Homo sapiens_hsa052140.26790662
117Acute myeloid leukemia_Homo sapiens_hsa052210.26370822
118Small cell lung cancer_Homo sapiens_hsa052220.25413842
119Insulin resistance_Homo sapiens_hsa049310.24746988
120Fanconi anemia pathway_Homo sapiens_hsa034600.24287210
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23842153
122HIF-1 signaling pathway_Homo sapiens_hsa040660.22477649
123HTLV-I infection_Homo sapiens_hsa051660.21772802
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.20554515
125Hippo signaling pathway_Homo sapiens_hsa043900.19815859
126Colorectal cancer_Homo sapiens_hsa052100.19139456
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.17761561
128Oxidative phosphorylation_Homo sapiens_hsa001900.17549567
129AMPK signaling pathway_Homo sapiens_hsa041520.17442500
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17118860
131Glucagon signaling pathway_Homo sapiens_hsa049220.13405916
132Huntingtons disease_Homo sapiens_hsa050160.13376582
133p53 signaling pathway_Homo sapiens_hsa041150.08490983
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.08243889

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