TRAPPC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.03018563
2negative regulation of erythrocyte differentiation (GO:0045647)4.28699494
3sodium ion export (GO:0071436)4.16690883
4regulation of gamma-delta T cell activation (GO:0046643)3.83823184
5synaptic vesicle maturation (GO:0016188)3.82572620
6locomotory exploration behavior (GO:0035641)3.79247834
7histone H3-K36 demethylation (GO:0070544)3.78636759
8protein localization to endosome (GO:0036010)3.77717255
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.76479347
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.74781206
11regulation of gamma-delta T cell differentiation (GO:0045586)3.71859734
12regulation of ARF protein signal transduction (GO:0032012)3.64586515
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63582692
14negative thymic T cell selection (GO:0045060)3.63337608
15regulation of B cell receptor signaling pathway (GO:0050855)3.61557110
16response to muramyl dipeptide (GO:0032495)3.60570729
17positive thymic T cell selection (GO:0045059)3.57895062
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57605197
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55648544
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.55648544
21modulation by symbiont of host immune response (GO:0052553)3.55648544
22positive regulation by symbiont of host defense response (GO:0052509)3.55648544
23modulation by symbiont of host defense response (GO:0052031)3.55648544
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55648544
25layer formation in cerebral cortex (GO:0021819)3.53879987
26negative T cell selection (GO:0043383)3.51950064
27antigen processing and presentation of endogenous antigen (GO:0019883)3.48841298
28cellular potassium ion homeostasis (GO:0030007)3.47908359
29thymic T cell selection (GO:0045061)3.43741016
30regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35143304
31B cell receptor signaling pathway (GO:0050853)3.35091179
32regulation of histone H3-K27 methylation (GO:0061085)3.28127301
33T cell selection (GO:0045058)3.26535308
34response to peptidoglycan (GO:0032494)3.25261744
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23643932
36positive T cell selection (GO:0043368)3.23378214
37regulation of clathrin-mediated endocytosis (GO:2000369)3.22932433
38cellular extravasation (GO:0045123)3.22025024
39embryonic process involved in female pregnancy (GO:0060136)3.21556288
40macrophage activation involved in immune response (GO:0002281)3.20374452
41mannose metabolic process (GO:0006013)3.19388691
42leukocyte aggregation (GO:0070486)3.15653799
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15010579
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12816141
45detection of other organism (GO:0098543)3.11426283
46activation of protein kinase A activity (GO:0034199)3.10413510
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09902439
48nuclear pore complex assembly (GO:0051292)3.06129703
49nerve growth factor signaling pathway (GO:0038180)3.04362972
50potassium ion import (GO:0010107)3.01298435
51response to laminar fluid shear stress (GO:0034616)2.99653414
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99604760
53germinal center formation (GO:0002467)2.95216843
54regulation of ARF GTPase activity (GO:0032312)2.93893536
55response to interleukin-15 (GO:0070672)2.92887332
56T cell migration (GO:0072678)2.92185933
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91856383
58detection of bacterium (GO:0016045)2.91058121
59plasma membrane repair (GO:0001778)2.88043302
60negative regulation of interleukin-12 production (GO:0032695)2.84937510
61cell communication by electrical coupling (GO:0010644)2.83711936
62glycine transport (GO:0015816)2.80673769
63cell communication involved in cardiac conduction (GO:0086065)2.80641516
64regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79392045
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78007124
66positive regulation of B cell differentiation (GO:0045579)2.76444364
67negative regulation of T cell mediated immunity (GO:0002710)2.75752491
68regulation of synapse structural plasticity (GO:0051823)2.74618533
69regulation of interferon-beta biosynthetic process (GO:0045357)2.72936610
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.72698038
71detection of molecule of bacterial origin (GO:0032490)2.71073657
72NIK/NF-kappaB signaling (GO:0038061)2.70690526
73regulation of synaptic vesicle exocytosis (GO:2000300)2.70514654
74glutamate secretion (GO:0014047)2.67938369
75detection of external biotic stimulus (GO:0098581)2.67498280
76regulation of B cell differentiation (GO:0045577)2.65287757
77histone lysine demethylation (GO:0070076)2.65284842
78neutrophil activation involved in immune response (GO:0002283)2.64951828
79regulation of necroptotic process (GO:0060544)2.64902313
80proline transport (GO:0015824)2.64774511
81tolerance induction (GO:0002507)2.64149072
82establishment of nucleus localization (GO:0040023)2.62903783
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62694853
84negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.62222400
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61633545
86antigen processing and presentation via MHC class Ib (GO:0002475)2.61223366
87regulation of NFAT protein import into nucleus (GO:0051532)2.58452528
88dendrite morphogenesis (GO:0048813)2.57942980
89JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57059753
90regulation of RNA export from nucleus (GO:0046831)2.56588931
91cytoplasmic mRNA processing body assembly (GO:0033962)2.56029734
92positive regulation of granulocyte differentiation (GO:0030854)2.55889485
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55882249
94vesicle transport along microtubule (GO:0047496)2.55517826
95phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.54173112
96histone demethylation (GO:0016577)2.53950916
97neuromuscular process controlling balance (GO:0050885)2.53165888
98establishment of protein localization to Golgi (GO:0072600)2.53077775
99regulation of nucleobase-containing compound transport (GO:0032239)2.52961156
100B cell homeostasis (GO:0001782)2.52900770
101cellular response to nerve growth factor stimulus (GO:1990090)2.51446770
102response to nerve growth factor (GO:1990089)2.51446770
103macroautophagy (GO:0016236)2.51313079
104regulation of leukocyte degranulation (GO:0043300)2.50964194
105response to host (GO:0075136)2.49184053
106response to host defenses (GO:0052200)2.49184053
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.49184053
108negative regulation of lymphocyte mediated immunity (GO:0002707)2.48736204
109protein targeting to Golgi (GO:0000042)2.48654253
110dendritic spine morphogenesis (GO:0060997)2.47892503
111nuclear pore organization (GO:0006999)2.47472117
112negative regulation of potassium ion transmembrane transport (GO:1901380)2.47273291
113positive regulation of histone deacetylation (GO:0031065)2.47130915
114potassium ion homeostasis (GO:0055075)2.46598870
115positive regulation of Rap GTPase activity (GO:0032854)2.45862556
116stress fiber assembly (GO:0043149)2.45775393
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.45624180
118alanine transport (GO:0032328)2.45556937
119clathrin coat assembly (GO:0048268)2.44778262
120cellular sodium ion homeostasis (GO:0006883)2.44686672
121production of molecular mediator involved in inflammatory response (GO:0002532)2.44414795
122hepatocyte apoptotic process (GO:0097284)2.43022252
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.42442444
124negative regulation of cell killing (GO:0031342)2.42442444
125megakaryocyte development (GO:0035855)2.40868840
126natural killer cell differentiation (GO:0001779)2.40742179
127regulation of T cell tolerance induction (GO:0002664)2.40650998
128histone H3-K9 demethylation (GO:0033169)2.40018515
129synaptic vesicle exocytosis (GO:0016079)2.38592236
130positive regulation of Cdc42 GTPase activity (GO:0043089)2.38576820
131detection of biotic stimulus (GO:0009595)2.38501779
132cortical actin cytoskeleton organization (GO:0030866)2.38057177
133cellular response to ethanol (GO:0071361)2.37103054
134response to host immune response (GO:0052572)2.36868811
135response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.36868811
136synaptic vesicle docking involved in exocytosis (GO:0016081)2.36746934
137L-amino acid import (GO:0043092)2.36277014
138regulation of Rap GTPase activity (GO:0032317)2.35661980
1393-UTR-mediated mRNA stabilization (GO:0070935)2.35580173
140regulation of T-helper 2 cell differentiation (GO:0045628)2.35019637
141negative regulation of leukocyte mediated immunity (GO:0002704)2.34994687
142retrograde transport, vesicle recycling within Golgi (GO:0000301)2.34488238
143histone H3-K4 trimethylation (GO:0080182)2.33050072
144type I interferon signaling pathway (GO:0060337)2.32921903
145cellular response to type I interferon (GO:0071357)2.32921903
146response to type I interferon (GO:0034340)2.32777834
147cerebellar Purkinje cell differentiation (GO:0021702)2.32364161
148vocalization behavior (GO:0071625)2.31939387
149cellular response to interleukin-15 (GO:0071350)2.30739670
150pinocytosis (GO:0006907)2.30155572
151regulation of tolerance induction (GO:0002643)2.29909035
152growth hormone receptor signaling pathway (GO:0060396)2.27624926
153negative regulation of toll-like receptor signaling pathway (GO:0034122)2.27597583
154myeloid cell activation involved in immune response (GO:0002275)2.27343515
155regulation of synaptic vesicle transport (GO:1902803)2.24827385
156membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.24005242
157peptidyl-tyrosine autophosphorylation (GO:0038083)2.23889396
158exploration behavior (GO:0035640)2.23462460
159prepulse inhibition (GO:0060134)2.22084717
160membrane repolarization (GO:0086009)2.21863277
161neurotransmitter secretion (GO:0007269)2.20785075
162positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.20512461
163gamma-aminobutyric acid transport (GO:0015812)2.19558857
164G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.18851576
165receptor catabolic process (GO:0032801)2.17982394
166regulation of glutamate receptor signaling pathway (GO:1900449)2.17506042
167organelle transport along microtubule (GO:0072384)2.17065074
168peptidyl-threonine phosphorylation (GO:0018107)2.16599408
169negative regulation of cell size (GO:0045792)2.16449887
170creatine metabolic process (GO:0006600)2.16020446
171regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.15214113
172peptidyl-threonine modification (GO:0018210)2.15047226
173regulation of neuronal synaptic plasticity (GO:0048168)2.14539551
174mating behavior (GO:0007617)2.12515115
175regulation of p38MAPK cascade (GO:1900744)2.12045581
176regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.11478177
177lipid translocation (GO:0034204)2.09319221
178phospholipid translocation (GO:0045332)2.09319221
179regulation of long-term neuronal synaptic plasticity (GO:0048169)2.09016442
180positive regulation of sodium ion transport (GO:0010765)2.08044396
181negative regulation of nucleotide catabolic process (GO:0030812)2.06535766
182positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.06222518
183cerebellar Purkinje cell layer development (GO:0021680)2.05511976
184relaxation of cardiac muscle (GO:0055119)2.05348488
185membrane tubulation (GO:0097320)2.05310524
186positive regulation of potassium ion transmembrane transport (GO:1901381)2.03063062
187regulation of dendritic spine morphogenesis (GO:0061001)2.02538267
188carnitine shuttle (GO:0006853)2.02406304
189CDP-diacylglycerol biosynthetic process (GO:0016024)2.02285145
190ionotropic glutamate receptor signaling pathway (GO:0035235)2.01136030
191cortical cytoskeleton organization (GO:0030865)2.00205373
192regulation of calcium ion transmembrane transporter activity (GO:1901019)1.99024957
193regulation of calcium ion transmembrane transport (GO:1903169)1.99024957
194axon cargo transport (GO:0008088)1.98798766
195neuronal action potential propagation (GO:0019227)1.98216883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.65480208
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58257674
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.14556121
4VDR_21846776_ChIP-Seq_THP-1_Human2.79812328
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.73146838
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62524543
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61521463
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55618821
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43207123
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43036821
11MAF_26560356_Chip-Seq_TH1_Human2.25759878
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20571033
13VDR_24763502_ChIP-Seq_THP-1_Human2.20144179
14DROSHA_22980978_ChIP-Seq_HELA_Human2.18264983
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16729619
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.13430981
17* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12961687
18SCL_19346495_ChIP-Seq_HPC-7_Human2.12361525
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09688702
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.00869529
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.97189375
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96788002
23MYB_26560356_Chip-Seq_TH2_Human1.94603930
24EZH2_22144423_ChIP-Seq_EOC_Human1.92598507
25KDM2B_26808549_Chip-Seq_K562_Human1.91143935
26MYB_26560356_Chip-Seq_TH1_Human1.89836004
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.89538547
28KDM2B_26808549_Chip-Seq_DND41_Human1.89401299
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87796068
30UTX_26944678_Chip-Seq_JUKART_Human1.86356392
31TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.82172041
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81181653
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.73903895
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73354817
35* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69185600
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.64508149
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.63597336
38GATA1_22025678_ChIP-Seq_K562_Human1.62718794
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61724839
40* SPI1_23547873_ChIP-Seq_NB4_Human1.59231496
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58248261
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58019497
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57620883
44* MAF_26560356_Chip-Seq_TH2_Human1.56825089
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55264888
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53867079
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52316376
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51442197
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50844510
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50196299
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.49220398
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47849410
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45942453
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45827889
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45785279
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45509971
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44371371
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44371371
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43608040
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.42791247
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41862692
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39893896
63GATA1_19941826_ChIP-Seq_K562_Human1.37887824
64ZNF263_19887448_ChIP-Seq_K562_Human1.37620982
65E2F7_22180533_ChIP-Seq_HELA_Human1.37315734
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36787245
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36421215
68TCF7_22412390_ChIP-Seq_EML_Mouse1.35384423
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34696235
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34494181
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33949831
72LXR_22292898_ChIP-Seq_THP-1_Human1.33003957
73* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32935643
74* PU_27001747_Chip-Seq_BMDM_Mouse1.31849307
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.28301115
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27303898
77* NCOR1_26117541_ChIP-Seq_K562_Human1.27257083
78* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27010621
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26208497
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.25905149
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23363714
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22677753
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21224774
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21019576
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20691844
86AR_21572438_ChIP-Seq_LNCaP_Human1.20416940
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20193165
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19860792
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19316786
90AHR_22903824_ChIP-Seq_MCF-7_Human1.18316251
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17955689
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17151390
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.16471976
94RACK7_27058665_Chip-Seq_MCF-7_Human1.16065539
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15965865
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15938532
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15269155
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.15038215
99GATA3_27048872_Chip-Seq_THYMUS_Human1.14821408
100VDR_24787735_ChIP-Seq_THP-1_Human1.13417205
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13325488
102SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13077791
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12708935
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.12137535
105TBX20_22328084_ChIP-Seq_HEART_Mouse1.12137535
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.12069061
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11927959
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11756455
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11672584
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11435739
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10918989
112CREB1_26743006_Chip-Seq_LNCaP_Human1.10631436
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10600830
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10348040
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.10002300
116REST_21632747_ChIP-Seq_MESCs_Mouse1.08810263
117SPI1_23127762_ChIP-Seq_K562_Human1.08401948
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07567723
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07340248
120GATA2_21666600_ChIP-Seq_HMVEC_Human1.06337741
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05986907
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05920734
123RXR_22108803_ChIP-Seq_LS180_Human1.05883068
124TP53_16413492_ChIP-PET_HCT116_Human1.05534358
125TFEB_21752829_ChIP-Seq_HELA_Human1.04762167
126* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04566815
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.03564680
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03515890
129TP63_17297297_ChIP-ChIP_HaCaT_Human1.03153333
130GATA2_19941826_ChIP-Seq_K562_Human1.01569738
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.01474630
132PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01111082
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99037790
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99035055
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98775674
136REST_18959480_ChIP-ChIP_MESCs_Mouse0.98324792
137* LXR_22158963_ChIP-Seq_LIVER_Mouse0.97883316
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97677754
139AR_19668381_ChIP-Seq_PC3_Human0.97016192
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96506209
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96226164
142RUNX_20019798_ChIP-Seq_JUKART_Human0.95993968
143CIITA_25753668_ChIP-Seq_RAJI_Human0.95631464
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95399232
145* ELK3_25401928_ChIP-Seq_HUVEC_Human0.95385891
146CLOCK_20551151_ChIP-Seq_293T_Human0.95242375
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95222766
148FOXM1_23109430_ChIP-Seq_U2OS_Human0.95015422
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94672375
150SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93971956
151SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93971956
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93676289
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.93576347
154SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93011392
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.91389535
156SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90871492
157KLF5_25053715_ChIP-Seq_YYC3_Human0.90323947
158SMAD_19615063_ChIP-ChIP_OVARY_Human0.89556963
159MYC_22102868_ChIP-Seq_BL_Human0.87050626
160GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86912084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.65424333
2MP0003300_gastrointestinal_ulcer3.08411586
3MP0003763_abnormal_thymus_physiology3.04324777
4MP0010234_abnormal_vibrissa_follicle3.01057502
5MP0003436_decreased_susceptibility_to3.00662898
6MP0009780_abnormal_chondrocyte_physiolo2.82151834
7MP0005451_abnormal_body_composition2.80966187
8MP0001835_abnormal_antigen_presentation2.72102145
9MP0004270_analgesia2.67164368
10MP0003329_amyloid_beta_deposits2.62668283
11MP0003303_peritoneal_inflammation2.59672106
12MP0000569_abnormal_digit_pigmentation2.59419385
13MP0003705_abnormal_hypodermis_morpholog2.53079976
14MP0004130_abnormal_muscle_cell2.51053770
15MP0003183_abnormal_peptide_metabolism2.34270271
16MP0003635_abnormal_synaptic_transmissio2.28825132
17MP0002909_abnormal_adrenal_gland2.22809454
18MP0001800_abnormal_humoral_immune2.20664706
19MP0004185_abnormal_adipocyte_glucose2.19909646
20MP0002396_abnormal_hematopoietic_system2.15753450
21MP0008961_abnormal_basal_metabolism2.14608528
22MP0005000_abnormal_immune_tolerance2.10476817
23MP0000685_abnormal_immune_system2.08655886
24MP0002009_preneoplasia2.06907813
25MP0008260_abnormal_autophagy2.06536706
26MP0000751_myopathy2.03720446
27MP0001790_abnormal_immune_system1.99593104
28MP0005387_immune_system_phenotype1.99593104
29MP0002419_abnormal_innate_immunity1.98898794
30MP0000604_amyloidosis1.95575979
31MP0003724_increased_susceptibility_to1.94915244
32MP0004510_myositis1.91926645
33MP0004858_abnormal_nervous_system1.89651473
34MP0002452_abnormal_antigen_presenting1.88295625
35MP0002420_abnormal_adaptive_immunity1.85472220
36MP0002723_abnormal_immune_serum1.85182012
37MP0005025_abnormal_response_to1.84424263
38MP0001819_abnormal_immune_cell1.83115125
39MP0005671_abnormal_response_to1.82172652
40MP0002398_abnormal_bone_marrow1.81683751
41MP0002166_altered_tumor_susceptibility1.81308594
42MP0003690_abnormal_glial_cell1.80428047
43MP0003045_fibrosis1.79023826
44MP0002837_dystrophic_cardiac_calcinosis1.72933398
45MP0005464_abnormal_platelet_physiology1.71495061
46MP0008057_abnormal_DNA_replication1.70842072
47MP0004808_abnormal_hematopoietic_stem1.68208717
48MP0000747_muscle_weakness1.67038550
49MP0002405_respiratory_system_inflammati1.65205657
50MP0009278_abnormal_bone_marrow1.64963708
51MP0003828_pulmonary_edema1.63078857
52MP0009333_abnormal_splenocyte_physiolog1.62451806
53MP0000703_abnormal_thymus_morphology1.59904961
54MP0008569_lethality_at_weaning1.59346357
55MP0002064_seizures1.59207996
56MP0002063_abnormal_learning/memory/cond1.58785374
57MP0009046_muscle_twitch1.58426286
58MP0010155_abnormal_intestine_physiology1.58127268
59MP0000716_abnormal_immune_system1.56716460
60MP0003172_abnormal_lysosome_physiology1.56239446
61MP0005666_abnormal_adipose_tissue1.54877502
62MP0002822_catalepsy1.50268704
63MP0001873_stomach_inflammation1.49200324
64MP0005076_abnormal_cell_differentiation1.46652447
65MP0000920_abnormal_myelination1.46457018
66MP0002722_abnormal_immune_system1.44407461
67MP0000858_altered_metastatic_potential1.44307349
68MP0003453_abnormal_keratinocyte_physiol1.44051513
69MP0009745_abnormal_behavioral_response1.42662214
70MP0005375_adipose_tissue_phenotype1.40800012
71MP0009785_altered_susceptibility_to1.39897885
72MP0005409_darkened_coat_color1.38744063
73MP0003075_altered_response_to1.37393821
74MP0004885_abnormal_endolymph1.37145436
75MP0004087_abnormal_muscle_fiber1.35888906
76MP0004381_abnormal_hair_follicle1.35475128
77MP0000689_abnormal_spleen_morphology1.35148022
78MP0001851_eye_inflammation1.35076134
79MP0000003_abnormal_adipose_tissue1.33923612
80MP0006082_CNS_inflammation1.33793480
81MP0002998_abnormal_bone_remodeling1.33406288
82MP0002429_abnormal_blood_cell1.33085282
83MP0001533_abnormal_skeleton_physiology1.30433589
84MP0003633_abnormal_nervous_system1.27291208
85MP0002006_tumorigenesis1.24816860
86MP0002148_abnormal_hypersensitivity_rea1.21770495
87MP0004084_abnormal_cardiac_muscle1.20945776
88MP0004811_abnormal_neuron_physiology1.19509237
89MP0001853_heart_inflammation1.18176374
90MP0005058_abnormal_lysosome_morphology1.18173778
91MP0001545_abnormal_hematopoietic_system1.17647376
92MP0005397_hematopoietic_system_phenotyp1.17647376
93MP0001845_abnormal_inflammatory_respons1.17507907
94MP0004264_abnormal_extraembryonic_tissu1.17187666
95MP0010352_gastrointestinal_tract_polyps1.16107467
96MP0004036_abnormal_muscle_relaxation1.15905320
97MP0002877_abnormal_melanocyte_morpholog1.15341225
98MP0003866_abnormal_defecation1.14745598
99MP0003091_abnormal_cell_migration1.14625208
100MP0002734_abnormal_mechanical_nocicepti1.12840644
101MP0003634_abnormal_glial_cell1.10781070
102MP0005167_abnormal_blood-brain_barrier1.10453269
103MP0000013_abnormal_adipose_tissue1.10342423
104MP0001501_abnormal_sleep_pattern1.09837662
105MP0005623_abnormal_meninges_morphology1.09563950
106MP0001486_abnormal_startle_reflex1.08769302
107MP0010678_abnormal_skin_adnexa1.06686202
108MP0005621_abnormal_cell_physiology1.05282868
109MP0000465_gastrointestinal_hemorrhage1.04510690
110MP0002272_abnormal_nervous_system1.01416667
111MP0009840_abnormal_foam_cell1.01365830
112MP0001299_abnormal_eye_distance/0.99931499
113MP0002572_abnormal_emotion/affect_behav0.98912157
114MP0000733_abnormal_muscle_development0.97949540
115MP0003283_abnormal_digestive_organ0.97627814
116MP0003448_altered_tumor_morphology0.97017696
117MP0004043_abnormal_pH_regulation0.96004998
118MP0003631_nervous_system_phenotype0.95509987
119MP0001440_abnormal_grooming_behavior0.94718285
120MP0005423_abnormal_somatic_nervous0.93974872
121MP0004947_skin_inflammation0.92657377
122MP0001849_ear_inflammation0.92583250
123MP0003566_abnormal_cell_adhesion0.92419606
124MP0010307_abnormal_tumor_latency0.92249656
125MP0004215_abnormal_myocardial_fiber0.91448875
126MP0004924_abnormal_behavior0.90755200
127MP0005386_behavior/neurological_phenoty0.90755200
128MP0002733_abnormal_thermal_nociception0.90650990
129MP0002971_abnormal_brown_adipose0.90005355
130MP0004145_abnormal_muscle_electrophysio0.87610165
131MP0002269_muscular_atrophy0.86440449
132MP0005310_abnormal_salivary_gland0.86123116
133MP0003880_abnormal_central_pattern0.85942897
134MP0000955_abnormal_spinal_cord0.85876970
135MP0001915_intracranial_hemorrhage0.85606915
136MP0005023_abnormal_wound_healing0.85537527
137MP0000015_abnormal_ear_pigmentation0.85338710
138MP0008874_decreased_physiological_sensi0.85292303
139MP0004233_abnormal_muscle_weight0.84470303
140MP0004484_altered_response_of0.83260802
141MP0008469_abnormal_protein_level0.82975378
142MP0002796_impaired_skin_barrier0.82932350
143MP0003221_abnormal_cardiomyocyte_apopto0.81833513
144MP0004883_abnormal_blood_vessel0.80847651
145MP0005535_abnormal_body_temperature0.80657451
146MP0010630_abnormal_cardiac_muscle0.80386084
147MP0003252_abnormal_bile_duct0.79612483
148MP0001765_abnormal_ion_homeostasis0.79389068
149MP0002066_abnormal_motor_capabilities/c0.79374622
150MP0000778_abnormal_nervous_system0.79131775
151MP0000759_abnormal_skeletal_muscle0.79032695
152MP0001970_abnormal_pain_threshold0.78630484
153MP0003879_abnormal_hair_cell0.78350399
154MP0001348_abnormal_lacrimal_gland0.76998735
155MP0000490_abnormal_crypts_of0.76928359
156MP0005620_abnormal_muscle_contractility0.76828747
157MP0005166_decreased_susceptibility_to0.76225458
158MP0002972_abnormal_cardiac_muscle0.75583320
159MP0009115_abnormal_fat_cell0.75010452
160MP0000749_muscle_degeneration0.74593353
161MP0003656_abnormal_erythrocyte_physiolo0.74194958
162MP0002229_neurodegeneration0.74082908
163MP0003632_abnormal_nervous_system0.73885192
164MP0003646_muscle_fatigue0.73813625
165MP0002118_abnormal_lipid_homeostasis0.72745931
166MP0003191_abnormal_cellular_cholesterol0.72185780
167MP0002019_abnormal_tumor_incidence0.70268235
168MP0001216_abnormal_epidermal_layer0.69858760
169MP0001958_emphysema0.69068259
170MP0002086_abnormal_extraembryonic_tissu0.68711009
171MP0005164_abnormal_response_to0.67494786

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.25412595
2Recurrent bacterial skin infections (HP:0005406)3.42802817
3Supranuclear gaze palsy (HP:0000605)3.24649097
4Recurrent abscess formation (HP:0002722)3.24140903
5Abnormality of the fingertips (HP:0001211)3.11152621
6Cerebral inclusion bodies (HP:0100314)3.09893175
7Hyporeflexia of lower limbs (HP:0002600)3.07525423
8Difficulty running (HP:0009046)2.94398667
9Macroorchidism (HP:0000053)2.94056099
10Abnormality of macrophages (HP:0004311)2.88596629
11T lymphocytopenia (HP:0005403)2.88231991
12Papilledema (HP:0001085)2.87506185
13Neurofibrillary tangles (HP:0002185)2.87103684
14Recurrent viral infections (HP:0004429)2.84803984
15Dysmetric saccades (HP:0000641)2.84279871
16Termporal pattern (HP:0011008)2.83276068
17Insidious onset (HP:0003587)2.83276068
18Colitis (HP:0002583)2.81586422
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.74667170
20Myokymia (HP:0002411)2.69068990
21Cellulitis (HP:0100658)2.68799971
22Action tremor (HP:0002345)2.68463538
23Spontaneous hematomas (HP:0007420)2.66219001
24Recurrent fungal infections (HP:0002841)2.61269429
25Insomnia (HP:0100785)2.58057431
26Bundle branch block (HP:0011710)2.58038325
27Visual hallucinations (HP:0002367)2.56037835
28Cerebral aneurysm (HP:0004944)2.55835398
29Abnormality of T cell number (HP:0011839)2.53130258
30Gingivitis (HP:0000230)2.52720110
31Hyperacusis (HP:0010780)2.49178502
32Gastrointestinal inflammation (HP:0004386)2.49123971
33Inflammation of the large intestine (HP:0002037)2.43856158
34Urinary urgency (HP:0000012)2.42225166
35Ventricular fibrillation (HP:0001663)2.42171064
36Ankle clonus (HP:0011448)2.39764157
37Slow saccadic eye movements (HP:0000514)2.38435367
38Increased IgE level (HP:0003212)2.38371488
39Broad face (HP:0000283)2.37725794
40Viral hepatitis (HP:0006562)2.36547093
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.34654046
42Exercise-induced myalgia (HP:0003738)2.34526340
43Mediastinal lymphadenopathy (HP:0100721)2.33712504
44Sudden death (HP:0001699)2.31340685
45Focal seizures (HP:0007359)2.30874129
46Vertebral arch anomaly (HP:0008438)2.30797116
47Myositis (HP:0100614)2.30485621
48Upper limb amyotrophy (HP:0009129)2.30426563
49Distal upper limb amyotrophy (HP:0007149)2.30426563
50Gastrointestinal infarctions (HP:0005244)2.29914893
51Intention tremor (HP:0002080)2.29862656
52Postural instability (HP:0002172)2.27631483
53Meningitis (HP:0001287)2.25491355
54Spinal cord lesions (HP:0100561)2.25356692
55Syringomyelia (HP:0003396)2.25356692
56Recurrent skin infections (HP:0001581)2.24952792
57Urinary bladder sphincter dysfunction (HP:0002839)2.23738524
58Frequent falls (HP:0002359)2.23284955
59Achilles tendon contracture (HP:0001771)2.22619939
60Hemiplegia (HP:0002301)2.20098857
61Pustule (HP:0200039)2.17632801
62Orchitis (HP:0100796)2.16243082
63Rapidly progressive (HP:0003678)2.15655893
64Chronic mucocutaneous candidiasis (HP:0002728)2.15504267
65Recurrent cutaneous fungal infections (HP:0011370)2.15504267
66Impaired social interactions (HP:0000735)2.12558221
67Abnormal social behavior (HP:0012433)2.12558221
68Resting tremor (HP:0002322)2.12265406
69Prolonged bleeding time (HP:0003010)2.11450954
70Neuronal loss in central nervous system (HP:0002529)2.11367183
71Lower limb amyotrophy (HP:0007210)2.10936213
72Recurrent gram-negative bacterial infections (HP:0005420)2.08875598
73Fatigue (HP:0012378)2.08245491
74Abnormality of the Achilles tendon (HP:0005109)2.07136766
75Megalencephaly (HP:0001355)2.05775621
76Optic neuritis (HP:0100653)2.03495714
77Retrobulbar optic neuritis (HP:0100654)2.03495714
78Dysmetria (HP:0001310)2.02643047
79Abnormality of oral frenula (HP:0000190)2.00918176
80Vasculitis (HP:0002633)2.00672081
81Dislocated radial head (HP:0003083)1.99578418
82Osteomyelitis (HP:0002754)1.99182589
83Flat acetabular roof (HP:0003180)1.99008510
84Impaired vibration sensation in the lower limbs (HP:0002166)1.98349822
85Abnormality of the corticospinal tract (HP:0002492)1.97102227
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.97047202
87Osteolytic defects of the hand bones (HP:0009699)1.97047202
88Autoimmune hemolytic anemia (HP:0001890)1.95748814
89Onion bulb formation (HP:0003383)1.95678339
90Depression (HP:0000716)1.95653686
91Chest pain (HP:0100749)1.95398058
92Hamartoma of the eye (HP:0010568)1.94936259
93Epistaxis (HP:0000421)1.94767332
94Exercise-induced muscle cramps (HP:0003710)1.92320172
95Spastic gait (HP:0002064)1.91836142
96Focal motor seizures (HP:0011153)1.91023672
97Obstructive sleep apnea (HP:0002870)1.90524466
98Scapular winging (HP:0003691)1.90357328
99Truncal ataxia (HP:0002078)1.89126512
100Elfin facies (HP:0004428)1.88896297
101Right ventricular cardiomyopathy (HP:0011663)1.88706762
102Increased variability in muscle fiber diameter (HP:0003557)1.88473460
103Neonatal hypoglycemia (HP:0001998)1.87410412
104Interstitial pulmonary disease (HP:0006530)1.87361552
105Arterial thrombosis (HP:0004420)1.86755874
106Pointed chin (HP:0000307)1.86621739
107Hand muscle atrophy (HP:0009130)1.86279258
108Chronic obstructive pulmonary disease (HP:0006510)1.86178236
109Obstructive lung disease (HP:0006536)1.86178236
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86068276
111Gingival bleeding (HP:0000225)1.85604992
112Dilatation of the ascending aorta (HP:0005111)1.84243405
113Myocardial infarction (HP:0001658)1.83513445
114Persistence of primary teeth (HP:0006335)1.82986117
115Difficulty climbing stairs (HP:0003551)1.82800974
116Distal lower limb amyotrophy (HP:0008944)1.81690322
117Verrucae (HP:0200043)1.81584736
118Papilloma (HP:0012740)1.81584736
119Abnormality of T cells (HP:0002843)1.80789912
120Gastrointestinal stroma tumor (HP:0100723)1.80749880
121Abnormal platelet volume (HP:0011876)1.80602916
122Abnormality of the lower motor neuron (HP:0002366)1.80007148
123Global brain atrophy (HP:0002283)1.78246535
124Spondylolisthesis (HP:0003302)1.78199195
125Abnormality of the radial head (HP:0003995)1.77702148
126Lower limb muscle weakness (HP:0007340)1.77146192
127Urinary glycosaminoglycan excretion (HP:0003541)1.76750906
128Mucopolysacchariduria (HP:0008155)1.76750906
129Long eyelashes (HP:0000527)1.75751419
130Shallow orbits (HP:0000586)1.74771301
131Muscle fiber splitting (HP:0003555)1.73937659
132Dysostosis multiplex (HP:0000943)1.73492925
133Agammaglobulinemia (HP:0004432)1.73085308
134Apathy (HP:0000741)1.72443011
135Subacute progressive viral hepatitis (HP:0006572)1.71557294
136Hammertoe (HP:0001765)1.71133788
137Panhypogammaglobulinemia (HP:0003139)1.71076738
138Ankyloglossia (HP:0010296)1.70061962
139Micronodular cirrhosis (HP:0001413)1.69717018
140Aneurysm (HP:0002617)1.69348505
141Segmental peripheral demyelination/remyelination (HP:0003481)1.68666329
142Overriding aorta (HP:0002623)1.66931166
143Dysdiadochokinesis (HP:0002075)1.66684678
144Poor eye contact (HP:0000817)1.66515923
145Lymphopenia (HP:0001888)1.66465282
146Genetic anticipation (HP:0003743)1.65646852
147Abnormality of cells of the lymphoid lineage (HP:0012140)1.65353051
148Buphthalmos (HP:0000557)1.65116971
149Heterotopia (HP:0002282)1.64957295
150Periodontitis (HP:0000704)1.64888676
151Abnormality of polysaccharide metabolism (HP:0011012)1.64709816
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64709816
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64709816
154Hypercortisolism (HP:0001578)1.64175672
155Pulmonary infiltrates (HP:0002113)1.63241855
156Disproportionate tall stature (HP:0001519)1.62924244
157Keratoconjunctivitis sicca (HP:0001097)1.62909458
158J-shaped sella turcica (HP:0002680)1.62680604
159Increased connective tissue (HP:0009025)1.62231913
160Asymmetry of the thorax (HP:0001555)1.62138540
161Mutism (HP:0002300)1.61938244
162Coarse hair (HP:0002208)1.61865874
163Enlarged penis (HP:0000040)1.61810465
164Atrioventricular block (HP:0001678)1.61755961
165Broad metatarsal (HP:0001783)1.61128925
166Asymmetric septal hypertrophy (HP:0001670)1.60744391
167Hepatitis (HP:0012115)1.60612577
168Granulocytopenia (HP:0001913)1.60238419
169Mitral valve prolapse (HP:0001634)1.60216742
170Arterial tortuosity (HP:0005116)1.59817091
171EMG: myopathic abnormalities (HP:0003458)1.59727478
172Increased CSF protein (HP:0002922)1.59661341
173Centrally nucleated skeletal muscle fibers (HP:0003687)1.59291240
174Syncope (HP:0001279)1.58776637
175Narrow palate (HP:0000189)1.58727909
176Prolonged QT interval (HP:0001657)1.58669242
177Acute myeloid leukemia (HP:0004808)1.58535938
178Myoglobinuria (HP:0002913)1.58361671
179Urticaria (HP:0001025)1.57811260
180Chronic diarrhea (HP:0002028)1.57491790
181Abnormality of the distal phalanx of the thumb (HP:0009617)1.56663193
182Abnormality of the thoracic spine (HP:0100711)1.56154884
183Abnormality of skeletal muscle fiber size (HP:0012084)1.55572512
184Encephalitis (HP:0002383)1.55516119
185Impaired smooth pursuit (HP:0007772)1.55251415
186Absent frontal sinuses (HP:0002688)1.55079564
187Thin bony cortex (HP:0002753)1.54599714
188Heart block (HP:0012722)1.54036191
189EMG: neuropathic changes (HP:0003445)1.53797098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.13905545
2TRIB33.72155542
3MAP3K92.79300191
4PKN22.57437732
5MAP3K142.22353342
6RIPK12.17966427
7KSR22.15478895
8SMG12.12427199
9EEF2K2.05656262
10TTN2.00913921
11PAK61.96053473
12TYK21.94926983
13LMTK21.93620812
14MAP2K31.89709600
15PRKD31.86963970
16CAMK1G1.80531351
17BLK1.80116363
18IRAK31.75401003
19NTRK11.72522778
20DAPK21.68211951
21EPHB11.67295637
22CAMKK11.63132229
23RET1.61815328
24DMPK1.61515338
25ZAP701.59842432
26MAP3K21.54630272
27TAOK11.53477501
28PTK61.51913312
29NTRK31.49090153
30MAP3K71.43479358
31TYRO31.41630954
32JAK31.38919732
33CAMK1D1.38648244
34CSK1.38347013
35IRAK41.38309803
36PRKCH1.35384750
37ALK1.34021523
38ICK1.33878018
39BTK1.32699264
40BRD41.32190375
41EPHA41.31273742
42MARK11.29821793
43MAP3K41.29533728
44PHKG11.28131401
45PHKG21.28131401
46SIK21.28054568
47SCYL21.27605842
48PDGFRA1.25565316
49MAP3K101.23973619
50SIK11.23503480
51IKBKE1.20856874
52FGFR21.09271524
53STK381.07746573
54SIK31.07523311
55STK111.06759537
56CDK61.06227371
57BMX1.05924606
58PDPK11.05246634
59MINK11.03143602
60JAK11.02841639
61MAP3K31.02711974
62WNK10.99979489
63PDK10.99223798
64TBK10.98030577
65CDK50.96550814
66BMPR20.96181577
67NTRK20.94143335
68PDGFRB0.93761772
69ERN10.93258979
70KSR10.92181267
71CDK40.90465477
72ITK0.89658782
73PAK30.89583802
74SYK0.88902365
75STK100.88768318
76MARK20.88258459
77MELK0.88087614
78SGK30.87272484
79RIPK40.85671248
80MAPK110.85045874
81LATS10.82000650
82MAP3K130.80482556
83FGFR30.79630577
84MAP3K10.79618345
85JAK20.79047611
86IRAK20.78695048
87PRKD10.78184666
88LRRK20.78047241
89MAP2K40.77014020
90FRK0.76068567
91TAOK20.76013571
92FES0.75706420
93TRPM70.74544097
94LCK0.73991209
95PTK20.71842775
96NEK90.71567112
97TXK0.71214073
98LATS20.69968419
99MTOR0.68801707
100MARK30.66806375
101YES10.66129437
102FGFR40.64643096
103CSF1R0.64211382
104STK390.64076132
105FYN0.63539955
106MAPK120.62256783
107PRKAA10.62149391
108IRAK10.62101045
109IKBKB0.61764093
110TEC0.61195062
111MAPK70.59918492
112CHUK0.59606923
113TNK20.58940751
114NLK0.58887198
115FER0.58755659
116CDC42BPA0.58615270
117PIM10.57200337
118RAF10.56427052
119SGK10.56300331
120LYN0.55931718
121HIPK20.55833158
122PKN10.55561016
123ROCK20.55348635
124SGK2230.55217412
125SGK4940.55217412
126NEK60.55212947
127PRKD20.53659042
128RPS6KA20.53390364
129MAP3K60.52435029
130SGK20.52018311
131WNK40.51983749
132DDR20.51685787
133MAP3K80.50875666
134TGFBR20.50666100
135HCK0.49534357
136CDK120.48867865
137RPS6KC10.48444255
138RPS6KL10.48444255
139MAP4K10.47797251
140UHMK10.46963446
141MST1R0.46824467
142ROCK10.46029544
143FGR0.44767436
144RPS6KA30.44607463
145MAP2K10.41236676
146OXSR10.41235790
147CAMKK20.40981209
148PRKAA20.40458754
149GRK60.39832551
150PRKCQ0.37972695
151PRKCZ0.37763565
152SRC0.37068151
153MET0.36834038

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.61260087
2Acute myeloid leukemia_Homo sapiens_hsa052212.14209831
3Leishmaniasis_Homo sapiens_hsa051401.81798255
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78517982
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69281885
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65702723
7Type II diabetes mellitus_Homo sapiens_hsa049301.62248622
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.61812025
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57837730
10Other glycan degradation_Homo sapiens_hsa005111.57050716
11Measles_Homo sapiens_hsa051621.56227886
12Gastric acid secretion_Homo sapiens_hsa049711.52999419
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50530979
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47878642
15Hepatitis B_Homo sapiens_hsa051611.46671916
16Long-term potentiation_Homo sapiens_hsa047201.43679207
17Influenza A_Homo sapiens_hsa051641.43417196
18Toxoplasmosis_Homo sapiens_hsa051451.41539830
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39606991
20Salivary secretion_Homo sapiens_hsa049701.39255873
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38675443
22TNF signaling pathway_Homo sapiens_hsa046681.37258130
23Olfactory transduction_Homo sapiens_hsa047401.33746652
24Dorso-ventral axis formation_Homo sapiens_hsa043201.33713918
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29739107
26Tuberculosis_Homo sapiens_hsa051521.29178819
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27442714
28Synaptic vesicle cycle_Homo sapiens_hsa047211.26378477
29Circadian entrainment_Homo sapiens_hsa047131.24971057
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23489418
31Glioma_Homo sapiens_hsa052141.22519774
32Cholinergic synapse_Homo sapiens_hsa047251.21204386
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20548103
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.20104912
35Hepatitis C_Homo sapiens_hsa051601.20075951
36Glutamatergic synapse_Homo sapiens_hsa047241.18742328
37Renin secretion_Homo sapiens_hsa049241.18665667
38mTOR signaling pathway_Homo sapiens_hsa041501.17943793
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17803531
40Herpes simplex infection_Homo sapiens_hsa051681.17494745
41Thyroid cancer_Homo sapiens_hsa052161.16977297
42Insulin secretion_Homo sapiens_hsa049111.16881597
43GABAergic synapse_Homo sapiens_hsa047271.16610105
44Prostate cancer_Homo sapiens_hsa052151.15748109
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13969972
46Primary immunodeficiency_Homo sapiens_hsa053401.13112048
47Graft-versus-host disease_Homo sapiens_hsa053321.12698682
48Estrogen signaling pathway_Homo sapiens_hsa049151.12638569
49Oxytocin signaling pathway_Homo sapiens_hsa049211.12497014
50Apoptosis_Homo sapiens_hsa042101.12326519
51Colorectal cancer_Homo sapiens_hsa052101.10278820
52GnRH signaling pathway_Homo sapiens_hsa049121.08196531
53Morphine addiction_Homo sapiens_hsa050321.08101631
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08044597
55Dilated cardiomyopathy_Homo sapiens_hsa054141.07887323
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07399106
57Allograft rejection_Homo sapiens_hsa053301.07283817
58Notch signaling pathway_Homo sapiens_hsa043301.07109017
59VEGF signaling pathway_Homo sapiens_hsa043701.07039408
60Dopaminergic synapse_Homo sapiens_hsa047281.06697911
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05866470
62Bile secretion_Homo sapiens_hsa049761.03754333
63Staphylococcus aureus infection_Homo sapiens_hsa051501.03706068
64Renal cell carcinoma_Homo sapiens_hsa052111.03577040
65Viral carcinogenesis_Homo sapiens_hsa052031.01334761
66Autoimmune thyroid disease_Homo sapiens_hsa053201.01117556
67Insulin resistance_Homo sapiens_hsa049311.00512147
68Phospholipase D signaling pathway_Homo sapiens_hsa040721.00004354
69Viral myocarditis_Homo sapiens_hsa054160.99923778
70Small cell lung cancer_Homo sapiens_hsa052220.99763035
71FoxO signaling pathway_Homo sapiens_hsa040680.99013695
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.98787295
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.98617786
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98481474
75Pancreatic secretion_Homo sapiens_hsa049720.96393204
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96364300
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95848880
78Malaria_Homo sapiens_hsa051440.94989749
79Non-small cell lung cancer_Homo sapiens_hsa052230.94196226
80Amphetamine addiction_Homo sapiens_hsa050310.94098892
81Endometrial cancer_Homo sapiens_hsa052130.93664612
82Chronic myeloid leukemia_Homo sapiens_hsa052200.92539110
83Bladder cancer_Homo sapiens_hsa052190.92490905
84Cocaine addiction_Homo sapiens_hsa050300.92088812
85ErbB signaling pathway_Homo sapiens_hsa040120.90482130
86cAMP signaling pathway_Homo sapiens_hsa040240.90166215
87Hematopoietic cell lineage_Homo sapiens_hsa046400.90106188
88MicroRNAs in cancer_Homo sapiens_hsa052060.89428843
89Gap junction_Homo sapiens_hsa045400.88611495
90HTLV-I infection_Homo sapiens_hsa051660.87099143
91Insulin signaling pathway_Homo sapiens_hsa049100.86243946
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85663071
93Long-term depression_Homo sapiens_hsa047300.84773823
94Shigellosis_Homo sapiens_hsa051310.83937649
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83720427
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83401369
97HIF-1 signaling pathway_Homo sapiens_hsa040660.83192453
98Fatty acid biosynthesis_Homo sapiens_hsa000610.81128017
99Endocytosis_Homo sapiens_hsa041440.80889822
100Antigen processing and presentation_Homo sapiens_hsa046120.80453490
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79429201
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79188157
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79032998
104Choline metabolism in cancer_Homo sapiens_hsa052310.78734417
105Legionellosis_Homo sapiens_hsa051340.76828460
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76325410
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75868436
108B cell receptor signaling pathway_Homo sapiens_hsa046620.75845001
109Pancreatic cancer_Homo sapiens_hsa052120.74955933
110Inositol phosphate metabolism_Homo sapiens_hsa005620.74870634
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74710864
112AMPK signaling pathway_Homo sapiens_hsa041520.73478064
113Adherens junction_Homo sapiens_hsa045200.73208370
114Platelet activation_Homo sapiens_hsa046110.72906526
115Arginine biosynthesis_Homo sapiens_hsa002200.72438140
116Thyroid hormone synthesis_Homo sapiens_hsa049180.72354669
117Epstein-Barr virus infection_Homo sapiens_hsa051690.72224368
118Axon guidance_Homo sapiens_hsa043600.70638813
119Focal adhesion_Homo sapiens_hsa045100.70578581
120Proteoglycans in cancer_Homo sapiens_hsa052050.70356399
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69410950
122Chemokine signaling pathway_Homo sapiens_hsa040620.69377473
123Osteoclast differentiation_Homo sapiens_hsa043800.68946300
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.68895537
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.68498891
126Calcium signaling pathway_Homo sapiens_hsa040200.67295716
127Glucagon signaling pathway_Homo sapiens_hsa049220.67259193
128MAPK signaling pathway_Homo sapiens_hsa040100.67056248
129Amoebiasis_Homo sapiens_hsa051460.66758062
130Prolactin signaling pathway_Homo sapiens_hsa049170.65739075
131Nicotine addiction_Homo sapiens_hsa050330.65495226
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.64352628
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.63516660
134Salmonella infection_Homo sapiens_hsa051320.61637239
135Type I diabetes mellitus_Homo sapiens_hsa049400.60391328
136Pertussis_Homo sapiens_hsa051330.60031163
137Rap1 signaling pathway_Homo sapiens_hsa040150.59952931
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59803190
139PPAR signaling pathway_Homo sapiens_hsa033200.59521842
140Glycerolipid metabolism_Homo sapiens_hsa005610.59345389
141T cell receptor signaling pathway_Homo sapiens_hsa046600.58850886
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.57443482
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56685791
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55685171
145African trypanosomiasis_Homo sapiens_hsa051430.55264766
146Melanogenesis_Homo sapiens_hsa049160.54375051
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54330041
148Lysine degradation_Homo sapiens_hsa003100.53057460
149Tight junction_Homo sapiens_hsa045300.52151497
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51488391
151Lysosome_Homo sapiens_hsa041420.49124792

Most similar genes based on co-expression Upload to Enrichr

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