TRAPPC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.10801378
2Golgi transport vesicle coating (GO:0048200)6.10801378
3nuclear pore complex assembly (GO:0051292)5.57945317
4neural tube formation (GO:0001841)5.09224221
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.08463949
6nuclear pore organization (GO:0006999)5.01905961
7dosage compensation (GO:0007549)4.52629465
8negative regulation of fibroblast apoptotic process (GO:2000270)4.51748398
9histone H3-K36 demethylation (GO:0070544)4.17599638
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.17187730
11monoubiquitinated protein deubiquitination (GO:0035520)4.17141961
12interkinetic nuclear migration (GO:0022027)4.06198900
13pore complex assembly (GO:0046931)4.03628693
14macroautophagy (GO:0016236)4.01590334
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.00458371
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.79573366
17L-phenylalanine catabolic process (GO:0006559)3.79573366
18activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.74085482
19pyrimidine dimer repair (GO:0006290)3.72994598
20histone lysine demethylation (GO:0070076)3.70839617
21regulation of RNA export from nucleus (GO:0046831)3.67860992
22L-alpha-amino acid transmembrane transport (GO:1902475)3.64268440
23lipid translocation (GO:0034204)3.63471103
24phospholipid translocation (GO:0045332)3.63471103
25histone mRNA catabolic process (GO:0071044)3.61061078
26protein targeting to Golgi (GO:0000042)3.60848832
27L-phenylalanine metabolic process (GO:0006558)3.57249876
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.57249876
29positive regulation of nuclease activity (GO:0032075)3.55959012
30vesicle coating (GO:0006901)3.53836884
31COPII vesicle coating (GO:0048208)3.53161398
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50089701
33cellular extravasation (GO:0045123)3.48415446
34histone demethylation (GO:0016577)3.46211031
35positive regulation of developmental pigmentation (GO:0048087)3.44798259
36establishment of protein localization to Golgi (GO:0072600)3.44388725
37peptidyl-lysine trimethylation (GO:0018023)3.42453460
38histone H3-K9 methylation (GO:0051567)3.42174889
39peptidyl-lysine dimethylation (GO:0018027)3.41046648
40activation of protein kinase A activity (GO:0034199)3.34648970
41nucleus localization (GO:0051647)3.32899940
42Golgi to endosome transport (GO:0006895)3.32114505
43histone H3-K4 trimethylation (GO:0080182)3.29313797
44pre-miRNA processing (GO:0031054)3.28888545
45regulation of pigment cell differentiation (GO:0050932)3.27555758
46intra-Golgi vesicle-mediated transport (GO:0006891)3.25580895
47dicarboxylic acid biosynthetic process (GO:0043650)3.25243154
48synaptic vesicle maturation (GO:0016188)3.21994635
49histone H3-K9 demethylation (GO:0033169)3.20210390
50regulation of nuclease activity (GO:0032069)3.19852780
51regulation of histone H3-K9 methylation (GO:0051570)3.18498460
52resolution of meiotic recombination intermediates (GO:0000712)3.18426305
53retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17303734
54positive regulation of gamma-delta T cell activation (GO:0046645)3.17110515
55activated T cell proliferation (GO:0050798)3.16852240
56regulation of telomere maintenance via telomerase (GO:0032210)3.15451520
57negative regulation of neurotransmitter secretion (GO:0046929)3.14946210
58endoplasmic reticulum unfolded protein response (GO:0030968)3.14862132
59alpha-linolenic acid metabolic process (GO:0036109)3.12328862
60myelin assembly (GO:0032288)3.11376131
61mitotic sister chromatid cohesion (GO:0007064)3.10328760
62histone H3-K9 modification (GO:0061647)3.07910709
63regulation of Golgi to plasma membrane protein transport (GO:0042996)3.06905448
64cytoplasmic mRNA processing body assembly (GO:0033962)3.06790329
65spermatid nucleus differentiation (GO:0007289)3.05836116
66protein demethylation (GO:0006482)3.04747701
67protein dealkylation (GO:0008214)3.04747701
68positive regulation of granulocyte differentiation (GO:0030854)3.03610026
69positive regulation of glycolytic process (GO:0045821)3.03379173
70alanine transport (GO:0032328)3.02132697
71peptidyl-threonine phosphorylation (GO:0018107)3.01164848
72ER-nucleus signaling pathway (GO:0006984)3.00826540
73microtubule nucleation (GO:0007020)2.98764617
74cellular response to unfolded protein (GO:0034620)2.98738252
75lateral ventricle development (GO:0021670)2.98077917
76gastrulation with mouth forming second (GO:0001702)2.97118771
77regulation of synaptic vesicle exocytosis (GO:2000300)2.97079556
78central nervous system projection neuron axonogenesis (GO:0021952)2.96994126
79peptidyl-threonine modification (GO:0018210)2.95900595
80clathrin coat assembly (GO:0048268)2.93010337
81microtubule anchoring (GO:0034453)2.91346258
82regulation of growth hormone secretion (GO:0060123)2.90088340
83acrosome assembly (GO:0001675)2.88375586
84pyrimidine nucleobase catabolic process (GO:0006208)2.88297853
85central nervous system neuron axonogenesis (GO:0021955)2.86957619
86regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.86628858
87cerebellar Purkinje cell layer development (GO:0021680)2.86407749
88peptidyl-lysine methylation (GO:0018022)2.86119205
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84580139
90protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.84532620
91regulation of chromatin silencing (GO:0031935)2.83502662
92head development (GO:0060322)2.83313835
93proline transport (GO:0015824)2.82664469
94positive regulation of mitochondrial fission (GO:0090141)2.82258230
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82070909
96cellular potassium ion homeostasis (GO:0030007)2.81778647
97regulation of cholesterol homeostasis (GO:2000188)2.79219031
98intraciliary transport (GO:0042073)2.78497192
99locomotory exploration behavior (GO:0035641)2.76527911
100cellular response to topologically incorrect protein (GO:0035967)2.74663043
101urea cycle (GO:0000050)2.74150148
102urea metabolic process (GO:0019627)2.74150148
103tyrosine metabolic process (GO:0006570)2.72543037
104regulation of erythrocyte differentiation (GO:0045646)2.71945747
105lysine catabolic process (GO:0006554)2.71787131
106lysine metabolic process (GO:0006553)2.71787131
107exocrine pancreas development (GO:0031017)2.70667208
108layer formation in cerebral cortex (GO:0021819)2.69896321
109DNA integration (GO:0015074)2.68723308
110neutrophil mediated immunity (GO:0002446)2.67930511
111vesicle transport along microtubule (GO:0047496)2.67490056
112cellular response to ethanol (GO:0071361)2.67462561
113olfactory bulb development (GO:0021772)2.67045738
114glutamate metabolic process (GO:0006536)2.65929504
115ER overload response (GO:0006983)2.65313046
116insulin secretion (GO:0030073)2.64575187
117protein localization to cilium (GO:0061512)2.63128531
118aromatic amino acid family catabolic process (GO:0009074)2.62972371
119negative regulation of translation, ncRNA-mediated (GO:0040033)2.61879885
120regulation of translation, ncRNA-mediated (GO:0045974)2.61879885
121negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61879885
122endocrine pancreas development (GO:0031018)2.61651736
123early endosome to late endosome transport (GO:0045022)2.61529084
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61327049
125regulation of protein polyubiquitination (GO:1902914)2.59607602
126histone lysine methylation (GO:0034968)2.59449873
127endoplasmic reticulum organization (GO:0007029)2.58819772
128protein localization to Golgi apparatus (GO:0034067)2.58571749
129positive regulation of B cell differentiation (GO:0045579)2.58539463
130detection of molecule of bacterial origin (GO:0032490)2.58188146
131response to endoplasmic reticulum stress (GO:0034976)2.56866312
132glutamate secretion (GO:0014047)2.55861004
133tricarboxylic acid metabolic process (GO:0072350)2.55791928
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.55298679
135regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.53546852
136tyrosine phosphorylation of STAT protein (GO:0007260)2.53469962
137glycoprotein catabolic process (GO:0006516)2.53203920
138regulation of ARF protein signal transduction (GO:0032012)2.52050239
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.51826482
140protein targeting to lysosome (GO:0006622)2.51505759
141establishment of protein localization to vacuole (GO:0072666)2.51505759
142protein targeting to vacuole (GO:0006623)2.51505759
143nucleus organization (GO:0006997)2.51373204
144negative regulation of DNA recombination (GO:0045910)2.50452386
145nerve growth factor signaling pathway (GO:0038180)2.50178913
146insulin-like growth factor receptor signaling pathway (GO:0048009)2.50079388
147mating behavior (GO:0007617)2.48804754
148synaptic vesicle exocytosis (GO:0016079)2.48798540
149regulation of clathrin-mediated endocytosis (GO:2000369)2.48558424
150regulation of nucleobase-containing compound transport (GO:0032239)2.48384683
151peptide hormone processing (GO:0016486)2.48252337
152maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47711582
153definitive hemopoiesis (GO:0060216)2.47601406
154Golgi organization (GO:0007030)2.46830939
155regulation of synaptic vesicle transport (GO:1902803)2.46773783
1564-hydroxyproline metabolic process (GO:0019471)2.46700371
157innervation (GO:0060384)2.46669056
158regulation of NFAT protein import into nucleus (GO:0051532)2.46476750
159negative regulation of DNA repair (GO:0045738)2.45457046
160fatty acid homeostasis (GO:0055089)2.44875534
161peptidyl-glutamic acid carboxylation (GO:0017187)2.44223176
162protein carboxylation (GO:0018214)2.44223176
163oxaloacetate metabolic process (GO:0006107)2.43757626
164sequestering of metal ion (GO:0051238)2.43587089
165phospholipid homeostasis (GO:0055091)2.43029044
166nitrogen cycle metabolic process (GO:0071941)2.42535689
167stress granule assembly (GO:0034063)2.42493739
168negative regulation of neurotransmitter transport (GO:0051589)2.42460704
169cellular response to glucagon stimulus (GO:0071377)2.41836828
170cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40888894
171negative regulation of cell size (GO:0045792)2.39194407
172regulation of calcium ion-dependent exocytosis (GO:0017158)2.39168888
173phospholipid dephosphorylation (GO:0046839)2.38902243
174organelle transport along microtubule (GO:0072384)2.38819270
175cellular ketone body metabolic process (GO:0046950)2.38523911
176cerebellar Purkinje cell differentiation (GO:0021702)2.38365340
177establishment of nucleus localization (GO:0040023)2.37899424
178negative regulation of histone methylation (GO:0031061)2.37478113
179auditory receptor cell differentiation (GO:0042491)2.37400079
180positive regulation of growth hormone secretion (GO:0060124)2.37127033
181sodium ion export (GO:0071436)2.34378485
182intestinal cholesterol absorption (GO:0030299)2.33736283
183triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.33503992
184phosphatidylinositol dephosphorylation (GO:0046856)2.32835328
185neurotransmitter secretion (GO:0007269)2.32357370
186lactate metabolic process (GO:0006089)2.29540382
187bile acid biosynthetic process (GO:0006699)2.29410044
188intestinal absorption (GO:0050892)2.28902230
189homocysteine metabolic process (GO:0050667)2.28782880
190drug transmembrane transport (GO:0006855)2.28230870
191cysteine metabolic process (GO:0006534)2.28085646
192NLS-bearing protein import into nucleus (GO:0006607)2.28070297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.37037296
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.29833870
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.30989871
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.10040731
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.00969581
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84899049
7IGF1R_20145208_ChIP-Seq_DFB_Human2.79126135
8TAF15_26573619_Chip-Seq_HEK293_Human2.63344134
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57534554
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52094261
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.51566966
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.47293557
13FUS_26573619_Chip-Seq_HEK293_Human2.44725144
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43141521
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39653914
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.31750405
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25341252
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19202577
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.17117867
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.11278198
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08136204
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06295959
23DROSHA_22980978_ChIP-Seq_HELA_Human2.02718254
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01580277
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.97997650
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.97706429
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96646771
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.90638284
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88657569
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.86290237
31EWS_26573619_Chip-Seq_HEK293_Human1.85905770
32CLOCK_20551151_ChIP-Seq_293T_Human1.77403264
33GATA1_22025678_ChIP-Seq_K562_Human1.75400993
34P300_19829295_ChIP-Seq_ESCs_Human1.69474208
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69393235
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.68460641
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68164463
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66543141
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65407990
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62403450
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61249064
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59214128
43IRF1_19129219_ChIP-ChIP_H3396_Human1.59192997
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58242256
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56497115
46CBP_20019798_ChIP-Seq_JUKART_Human1.56460720
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56460720
48REST_21632747_ChIP-Seq_MESCs_Mouse1.50730687
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49476949
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49150493
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.48929938
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47544303
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46137179
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45960334
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.44872347
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44669932
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43179690
58TP53_16413492_ChIP-PET_HCT116_Human1.42525803
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38197473
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37883066
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37723872
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37412026
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36826830
64ER_23166858_ChIP-Seq_MCF-7_Human1.36760184
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36093990
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33995729
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33995729
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.33876459
69GBX2_23144817_ChIP-Seq_PC3_Human1.33761209
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33421587
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.33118197
72AR_19668381_ChIP-Seq_PC3_Human1.30917247
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.30877761
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30873132
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30841534
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.30539436
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29294458
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29128259
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28335156
80ELK1_19687146_ChIP-ChIP_HELA_Human1.27877305
81STAT3_23295773_ChIP-Seq_U87_Human1.27797843
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.27414989
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26453399
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26239492
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.24337077
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24174181
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23933705
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.23868032
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23363085
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21589446
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.20033427
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19234834
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19162175
94ZNF274_21170338_ChIP-Seq_K562_Hela1.18597585
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18342660
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.18203453
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17467131
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17105494
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16777592
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16675493
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16645431
102RUNX2_22187159_ChIP-Seq_PCA_Human1.16540014
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16529662
104KDM2B_26808549_Chip-Seq_K562_Human1.15848415
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15108693
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15044569
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13448262
108AR_25329375_ChIP-Seq_VCAP_Human1.11624843
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11231592
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10826551
111TCF4_23295773_ChIP-Seq_U87_Human1.10021635
112CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09784737
113PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09783048
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.09758461
115EZH2_22144423_ChIP-Seq_EOC_Human1.09665606
116SALL4_22934838_ChIP-ChIP_CD34+_Human1.09512888
117PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09326957
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09057840
119VDR_24787735_ChIP-Seq_THP-1_Human1.08910584
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08837126
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08667619
122PIAS1_25552417_ChIP-Seq_VCAP_Human1.07357796
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06949645
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06649241
125SMAD4_21799915_ChIP-Seq_A2780_Human1.06599640
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05784063
127HNF4A_19822575_ChIP-Seq_HepG2_Human1.05743864
128P53_22387025_ChIP-Seq_ESCs_Mouse1.04889173
129SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04742858
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04667289
131BCAT_22108803_ChIP-Seq_LS180_Human1.04618527
132CDX2_22108803_ChIP-Seq_LS180_Human1.04439053
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03445618
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02743195
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02433529
136WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01763754
137PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01637351
138KDM2B_26808549_Chip-Seq_DND41_Human1.01171998
139EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01055206
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00430324
141AR_21572438_ChIP-Seq_LNCaP_Human1.00390866
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99958745
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99862407
144TCF4_22108803_ChIP-Seq_LS180_Human0.99487156
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99196823
146CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99144055
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99004862
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.97999200
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97640729
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.97509798
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96728015
152MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96129205
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95618739
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.93538024
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93124266
156CREB1_26743006_Chip-Seq_LNCaP_Human0.92931629
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.92632447
158TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92573333
159AHR_22903824_ChIP-Seq_MCF-7_Human0.92507209
160SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90699807
161NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90206707
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90206707
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.88965248
164TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88831787
165TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88295662
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87609339
167SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87362909
168ZNF263_19887448_ChIP-Seq_K562_Human0.84879679
169CHD1_26751641_Chip-Seq_LNCaP_Human0.84287971
170OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83687255
171TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82947053
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81147740
173SMAD4_21741376_ChIP-Seq_HESCs_Human0.80480648
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80077831
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79762147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.94628277
2MP0009780_abnormal_chondrocyte_physiolo3.59617036
3MP0002139_abnormal_hepatobiliary_system3.31196001
4MP0008057_abnormal_DNA_replication3.30117316
5MP0002009_preneoplasia3.30082256
6MP0005365_abnormal_bile_salt3.22971838
7MP0005360_urolithiasis3.07411412
8MP0003221_abnormal_cardiomyocyte_apopto3.05906134
9MP0004859_abnormal_synaptic_plasticity2.95432811
10MP0002909_abnormal_adrenal_gland2.91372360
11MP0010234_abnormal_vibrissa_follicle2.87079215
12MP0005085_abnormal_gallbladder_physiolo2.76179286
13MP0000013_abnormal_adipose_tissue2.65840751
14MP0004043_abnormal_pH_regulation2.48782208
15MP0003283_abnormal_digestive_organ2.44541723
16MP0002102_abnormal_ear_morphology2.39005240
17MP0003252_abnormal_bile_duct2.37512412
18MP0002877_abnormal_melanocyte_morpholog2.35731881
19MP0000569_abnormal_digit_pigmentation2.35342093
20MP0003172_abnormal_lysosome_physiology2.26476021
21MP0008877_abnormal_DNA_methylation2.25860535
22MP0000778_abnormal_nervous_system2.19210365
23MP0005451_abnormal_body_composition2.18748518
24MP0008961_abnormal_basal_metabolism2.18405706
25MP0004270_analgesia2.13133690
26MP0001986_abnormal_taste_sensitivity2.05972396
27MP0003705_abnormal_hypodermis_morpholog1.98921160
28MP0010329_abnormal_lipoprotein_level1.98838702
29MP0000003_abnormal_adipose_tissue1.98581512
30MP0003656_abnormal_erythrocyte_physiolo1.88795787
31MP0003195_calcinosis1.85622204
32MP0001944_abnormal_pancreas_morphology1.84032117
33MP0003635_abnormal_synaptic_transmissio1.80347295
34MP0010386_abnormal_urinary_bladder1.79255611
35MP0002837_dystrophic_cardiac_calcinosis1.78881794
36MP0003329_amyloid_beta_deposits1.74438362
37MP0002693_abnormal_pancreas_physiology1.74280238
38MP0008260_abnormal_autophagy1.73928306
39MP0003868_abnormal_feces_composition1.72127146
40MP0002078_abnormal_glucose_homeostasis1.70837298
41MP0005083_abnormal_biliary_tract1.68936086
42MP0003191_abnormal_cellular_cholesterol1.68162177
43MP0005220_abnormal_exocrine_pancreas1.62976457
44MP0003300_gastrointestinal_ulcer1.62949654
45MP0009697_abnormal_copulation1.61801331
46MP0000604_amyloidosis1.60988652
47MP0008875_abnormal_xenobiotic_pharmacok1.60449560
48MP0005248_abnormal_Harderian_gland1.59629434
49MP0001666_abnormal_nutrient_absorption1.57967323
50MP0000427_abnormal_hair_cycle1.56988190
51MP0002396_abnormal_hematopoietic_system1.55023340
52MP0000015_abnormal_ear_pigmentation1.54157310
53MP0005058_abnormal_lysosome_morphology1.52298285
54MP0004130_abnormal_muscle_cell1.50989238
55MP0005187_abnormal_penis_morphology1.48190287
56MP0003567_abnormal_fetal_cardiomyocyte1.47003219
57MP0001984_abnormal_olfaction1.45511671
58MP0004134_abnormal_chest_morphology1.40353776
59MP0002063_abnormal_learning/memory/cond1.39807086
60MP0010352_gastrointestinal_tract_polyps1.36974661
61MP0005499_abnormal_olfactory_system1.32837376
62MP0005394_taste/olfaction_phenotype1.32837376
63MP0002233_abnormal_nose_morphology1.32501392
64MP0005075_abnormal_melanosome_morpholog1.30569787
65MP0006072_abnormal_retinal_apoptosis1.30461369
66MP0005076_abnormal_cell_differentiation1.28027291
67MP0010678_abnormal_skin_adnexa1.26988803
68MP0008789_abnormal_olfactory_epithelium1.26374240
69MP0000428_abnormal_craniofacial_morphol1.26130580
70MP0009703_decreased_birth_body1.25735531
71MP0000383_abnormal_hair_follicle1.25251308
72MP0002090_abnormal_vision1.24704265
73MP0005379_endocrine/exocrine_gland_phen1.24565052
74MP0006276_abnormal_autonomic_nervous1.24551362
75MP0005171_absent_coat_pigmentation1.23613273
76MP0004233_abnormal_muscle_weight1.22097324
77MP0004084_abnormal_cardiac_muscle1.21148996
78MP0002118_abnormal_lipid_homeostasis1.20824423
79MP0002092_abnormal_eye_morphology1.18927120
80MP0001293_anophthalmia1.18713625
81MP0005332_abnormal_amino_acid1.17777625
82MP0003123_paternal_imprinting1.17561987
83MP0002064_seizures1.17250410
84MP0003646_muscle_fatigue1.17072728
85MP0000609_abnormal_liver_physiology1.14642226
86MP0002084_abnormal_developmental_patter1.14514240
87MP0003880_abnormal_central_pattern1.14482639
88MP0003122_maternal_imprinting1.13727474
89MP0004811_abnormal_neuron_physiology1.13279687
90MP0004197_abnormal_fetal_growth/weight/1.13122400
91MP0002095_abnormal_skin_pigmentation1.12161230
92MP0003828_pulmonary_edema1.11310523
93MP0005375_adipose_tissue_phenotype1.10106364
94MP0003633_abnormal_nervous_system1.08473882
95MP0003303_peritoneal_inflammation1.08163447
96MP0005535_abnormal_body_temperature1.06811121
97MP0004264_abnormal_extraembryonic_tissu1.06068381
98MP0004145_abnormal_muscle_electrophysio1.05915508
99MP0005448_abnormal_energy_balance1.05862184
100MP0002127_abnormal_cardiovascular_syste1.05827977
101MP0000371_diluted_coat_color1.04576652
102MP0003045_fibrosis1.04542784
103MP0010307_abnormal_tumor_latency1.04508977
104MP0005551_abnormal_eye_electrophysiolog1.02599488
105MP0004808_abnormal_hematopoietic_stem1.00484108
106MP0003935_abnormal_craniofacial_develop1.00391377
107MP0009840_abnormal_foam_cell0.99782004
108MP0002734_abnormal_mechanical_nocicepti0.99204928
109MP0009745_abnormal_behavioral_response0.97686961
110MP0003879_abnormal_hair_cell0.97516470
111MP0002088_abnormal_embryonic_growth/wei0.96786501
112MP0003385_abnormal_body_wall0.96694467
113MP0003984_embryonic_growth_retardation0.96565406
114MP0001324_abnormal_eye_pigmentation0.95129077
115MP0003861_abnormal_nervous_system0.94654940
116MP0009672_abnormal_birth_weight0.94560000
117MP0002928_abnormal_bile_duct0.94417119
118MP0005397_hematopoietic_system_phenotyp0.94208704
119MP0001545_abnormal_hematopoietic_system0.94208704
120MP0003690_abnormal_glial_cell0.92789933
121MP0002896_abnormal_bone_mineralization0.92620826
122MP0005174_abnormal_tail_pigmentation0.92578452
123MP0004484_altered_response_of0.91790197
124MP0002733_abnormal_thermal_nociception0.91586483
125MP0009046_muscle_twitch0.90272628
126MP0001299_abnormal_eye_distance/0.89192791
127MP0002166_altered_tumor_susceptibility0.88755668
128MP0003806_abnormal_nucleotide_metabolis0.88173166
129MP0002822_catalepsy0.87745888
130MP0002572_abnormal_emotion/affect_behav0.87580931
131MP0001765_abnormal_ion_homeostasis0.87537684
132MP0005391_vision/eye_phenotype0.87471161
133MP0003890_abnormal_embryonic-extraembry0.87163346
134MP0004883_abnormal_blood_vessel0.87063360
135MP0003953_abnormal_hormone_level0.85832685
136MP0001661_extended_life_span0.83818586
137MP0004858_abnormal_nervous_system0.82590780
138MP0001756_abnormal_urination0.82339179
139MP0005253_abnormal_eye_physiology0.82079153
140MP0004885_abnormal_endolymph0.82059528
141MP0003937_abnormal_limbs/digits/tail_de0.81457062
142MP0003787_abnormal_imprinting0.81150414
143MP0009643_abnormal_urine_homeostasis0.80941239
144MP0001672_abnormal_embryogenesis/_devel0.80786421
145MP0005380_embryogenesis_phenotype0.80786421
146MP0008995_early_reproductive_senescence0.79372869
147MP0003943_abnormal_hepatobiliary_system0.79289071
148MP0001177_atelectasis0.79278417
149MP0002229_neurodegeneration0.78968204
150MP0000631_abnormal_neuroendocrine_gland0.78953887
151MP0001286_abnormal_eye_development0.78773251
152MP0000955_abnormal_spinal_cord0.77493849
153MP0000647_abnormal_sebaceous_gland0.76915253
154MP0002751_abnormal_autonomic_nervous0.76271469
155MP0002006_tumorigenesis0.75167646
156MP0003631_nervous_system_phenotype0.74425220
157MP0008004_abnormal_stomach_pH0.74410493
158MP0002152_abnormal_brain_morphology0.74214173
159MP0000266_abnormal_heart_morphology0.73789718
160MP0005334_abnormal_fat_pad0.73186810
161MP0005408_hypopigmentation0.73109500
162MP0002272_abnormal_nervous_system0.72708568
163MP0003959_abnormal_lean_body0.72363912
164MP0001501_abnormal_sleep_pattern0.72297830
165MP0002269_muscular_atrophy0.71921641
166MP0005319_abnormal_enzyme/_coenzyme0.71077072
167MP0002086_abnormal_extraembryonic_tissu0.70181849
168MP0001697_abnormal_embryo_size0.69283804
169MP0004924_abnormal_behavior0.68133974
170MP0005386_behavior/neurological_phenoty0.68133974
171MP0005645_abnormal_hypothalamus_physiol0.67230262
172MP0002069_abnormal_eating/drinking_beha0.66872039
173MP0002106_abnormal_muscle_physiology0.66843377
174MP0003121_genomic_imprinting0.66536499
175MP0002882_abnormal_neuron_morphology0.66087539
176MP0003632_abnormal_nervous_system0.65785106
177MP0003634_abnormal_glial_cell0.63712968

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.23201740
2Tubulointerstitial nephritis (HP:0001970)4.17962661
3Hyperinsulinemic hypoglycemia (HP:0000825)4.15363772
4Thyroid carcinoma (HP:0002890)3.64171662
5Hypoglycemic coma (HP:0001325)3.62833099
6Symptomatic seizures (HP:0011145)3.35482495
7Ketoacidosis (HP:0001993)3.29647666
8Rhabdomyosarcoma (HP:0002859)3.26738220
9Abnormality of the lower motor neuron (HP:0002366)3.23377145
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.19157617
11Medulloblastoma (HP:0002885)3.19018233
12Abnormality of endocrine pancreas physiology (HP:0012093)3.17465152
13Abnormality of the pancreatic islet cells (HP:0006476)3.17465152
14Curly hair (HP:0002212)3.14778317
15Large earlobe (HP:0009748)3.13446558
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.04942389
17Hepatoblastoma (HP:0002884)2.98133514
18Resting tremor (HP:0002322)2.93999428
19Macroorchidism (HP:0000053)2.87210729
20Ketosis (HP:0001946)2.86890461
21* Hip dysplasia (HP:0001385)2.84587343
22Visual hallucinations (HP:0002367)2.83908933
23Hyperglycemia (HP:0003074)2.83157345
24Acute myeloid leukemia (HP:0004808)2.81694325
25Cortical dysplasia (HP:0002539)2.80847860
26Drooling (HP:0002307)2.73229094
27Global brain atrophy (HP:0002283)2.70744111
28Deep venous thrombosis (HP:0002625)2.70419949
29Gonadotropin excess (HP:0000837)2.64399063
30Volvulus (HP:0002580)2.64309309
31Agitation (HP:0000713)2.63395056
32Intrahepatic cholestasis (HP:0001406)2.60664323
33Excessive salivation (HP:0003781)2.59018885
34Diastasis recti (HP:0001540)2.58806688
35Hyperventilation (HP:0002883)2.52067122
36Chronic hepatic failure (HP:0100626)2.51903479
37Cerebral inclusion bodies (HP:0100314)2.51651915
38Oligodactyly (hands) (HP:0001180)2.48913966
39Skin nodule (HP:0200036)2.47995283
40Cystic hygroma (HP:0000476)2.47327306
41EEG with generalized epileptiform discharges (HP:0011198)2.47068174
42Hypobetalipoproteinemia (HP:0003563)2.45529168
43Agnosia (HP:0010524)2.42839825
44Pancreatic islet-cell hyperplasia (HP:0004510)2.42669003
45Epileptiform EEG discharges (HP:0011182)2.40787412
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40517061
47Abnormality of the intrinsic pathway (HP:0010989)2.38945334
48Xanthomatosis (HP:0000991)2.37394904
49Absence seizures (HP:0002121)2.37259415
50Hypsarrhythmia (HP:0002521)2.35068260
51Colon cancer (HP:0003003)2.32379772
52Tubulointerstitial abnormality (HP:0001969)2.28415147
53Impaired vibration sensation in the lower limbs (HP:0002166)2.27511344
54Retinal atrophy (HP:0001105)2.27314530
55Growth hormone deficiency (HP:0000824)2.26229251
56Febrile seizures (HP:0002373)2.24774105
57Depression (HP:0000716)2.24355815
58Supranuclear gaze palsy (HP:0000605)2.23974792
59Urinary urgency (HP:0000012)2.23471463
60Abnormal hair whorl (HP:0010721)2.23445997
61Abnormality of the common coagulation pathway (HP:0010990)2.23185569
62Astrocytoma (HP:0009592)2.22666629
63Abnormality of the astrocytes (HP:0100707)2.22666629
64Insidious onset (HP:0003587)2.22653335
65Termporal pattern (HP:0011008)2.22653335
66Neoplasm of the adrenal cortex (HP:0100641)2.21249115
67Widely spaced teeth (HP:0000687)2.20030110
68Intestinal atresia (HP:0011100)2.19668179
69Thickened calvaria (HP:0002684)2.18744956
70Pheochromocytoma (HP:0002666)2.18536544
71Neoplasm of striated muscle (HP:0009728)2.18279259
72Mucopolysacchariduria (HP:0008155)2.16963614
73Urinary glycosaminoglycan excretion (HP:0003541)2.16963614
74Focal seizures (HP:0007359)2.16065518
75Spastic gait (HP:0002064)2.15989736
76Long clavicles (HP:0000890)2.15902911
77Hand muscle atrophy (HP:0009130)2.14010270
78Aqueductal stenosis (HP:0002410)2.13317029
79Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.13113148
80Epidermoid cyst (HP:0200040)2.10871928
81Anteriorly placed anus (HP:0001545)2.08613702
82Neoplasm of the heart (HP:0100544)2.08605753
83Lower limb muscle weakness (HP:0007340)2.08387050
84Renal cortical cysts (HP:0000803)2.07859349
85Ependymoma (HP:0002888)2.07191838
86Atonic seizures (HP:0010819)2.06717760
87Urinary bladder sphincter dysfunction (HP:0002839)2.05764001
88Protruding tongue (HP:0010808)2.05608159
89Fair hair (HP:0002286)2.05257003
90Dysostosis multiplex (HP:0000943)2.03378017
91Abnormality of polysaccharide metabolism (HP:0011012)2.02330463
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02330463
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02330463
94Absent speech (HP:0001344)2.01860543
95Cutis marmorata (HP:0000965)2.00886273
96Impaired smooth pursuit (HP:0007772)2.00687706
97Sandal gap (HP:0001852)2.00003883
98Impaired social interactions (HP:0000735)1.99150462
99Abnormal social behavior (HP:0012433)1.99150462
100Biliary tract neoplasm (HP:0100574)1.98631055
101Glioma (HP:0009733)1.98479608
102Amyotrophic lateral sclerosis (HP:0007354)1.98170879
103Truncal obesity (HP:0001956)1.98134200
104Neoplasm of the small intestine (HP:0100833)1.97204645
105Abnormality of the renal medulla (HP:0100957)1.96472596
106Thyroiditis (HP:0100646)1.96301411
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95554001
108Abnormality of the parathyroid morphology (HP:0011766)1.95535135
109Heterotopia (HP:0002282)1.94399246
110Dialeptic seizures (HP:0011146)1.94134776
111Neurofibrillary tangles (HP:0002185)1.92958953
112Limb hypertonia (HP:0002509)1.91981498
113Clonus (HP:0002169)1.91831649
114Relative macrocephaly (HP:0004482)1.90550283
115Deep philtrum (HP:0002002)1.89855915
116Freckling (HP:0001480)1.89719964
117Amaurosis fugax (HP:0100576)1.89117837
118Hyperglycinemia (HP:0002154)1.88481286
119Acute lymphatic leukemia (HP:0006721)1.88068952
120Abnormal pancreas size (HP:0012094)1.87839878
121Thick eyebrow (HP:0000574)1.86418509
122Generalized tonic-clonic seizures (HP:0002069)1.86341067
123Overgrowth (HP:0001548)1.85790534
124Upper limb amyotrophy (HP:0009129)1.84454854
125Distal upper limb amyotrophy (HP:0007149)1.84454854
126Neuroendocrine neoplasm (HP:0100634)1.84272561
127Vertebral arch anomaly (HP:0008438)1.84221197
128Cerebral aneurysm (HP:0004944)1.83666674
129Abnormality of ocular smooth pursuit (HP:0000617)1.83071061
130Death in childhood (HP:0003819)1.82541959
131High anterior hairline (HP:0009890)1.82188735
132Postural instability (HP:0002172)1.82184478
133Neoplasm of the thyroid gland (HP:0100031)1.82181886
134Papillary thyroid carcinoma (HP:0002895)1.81697912
135Late onset (HP:0003584)1.81160070
136Subacute progressive viral hepatitis (HP:0006572)1.81116371
137Postural tremor (HP:0002174)1.80814046
138Neoplasm of the oral cavity (HP:0100649)1.80588793
139Obsessive-compulsive behavior (HP:0000722)1.80420861
140Abnormality of the corticospinal tract (HP:0002492)1.79939423
141Pulmonic stenosis (HP:0001642)1.79863700
142Basal cell carcinoma (HP:0002671)1.79820183
143Transitional cell carcinoma of the bladder (HP:0006740)1.79008098
144Dysmetric saccades (HP:0000641)1.78905147
145Enlarged penis (HP:0000040)1.78843795
146Broad ribs (HP:0000885)1.78482429
147Hypoplastic labia majora (HP:0000059)1.78448338
148Status epilepticus (HP:0002133)1.77978501
149Lower limb hyperreflexia (HP:0002395)1.77717139
150Focal motor seizures (HP:0011153)1.77373164
151Truncal ataxia (HP:0002078)1.77338311
152Hyperlipoproteinemia (HP:0010980)1.76720185
153Decreased circulating renin level (HP:0003351)1.76710516
154Long toe (HP:0010511)1.76606945
155Protuberant abdomen (HP:0001538)1.76549181
156Gout (HP:0001997)1.76536570
157Generalized hyperpigmentation (HP:0007440)1.76242969
158Broad palm (HP:0001169)1.76203614
159Turricephaly (HP:0000262)1.75932201
160Rimmed vacuoles (HP:0003805)1.75759334
161Complement deficiency (HP:0004431)1.75108063
162Intellectual disability, profound (HP:0002187)1.74669471
163Nephronophthisis (HP:0000090)1.74423660
164Back pain (HP:0003418)1.74301331
165Papilledema (HP:0001085)1.74281003
166Cupped ear (HP:0000378)1.74099863
167Difficulty running (HP:0009046)1.73990619
168Bladder carcinoma (HP:0002862)1.73488497
169Bladder neoplasm (HP:0009725)1.73488497
170Stenosis of the external auditory canal (HP:0000402)1.73475620
171Hypolipoproteinemia (HP:0010981)1.73004052
172Tetraplegia (HP:0002445)1.71120723
173Restlessness (HP:0000711)1.70440850
174Insulin-resistant diabetes mellitus (HP:0000831)1.70314474
175Abnormality of the renal cortex (HP:0011035)1.70142821
176Insomnia (HP:0100785)1.70116733
177Nephrogenic diabetes insipidus (HP:0009806)1.68351267
178Malignant gastrointestinal tract tumors (HP:0006749)1.67608820
179Gastrointestinal carcinoma (HP:0002672)1.67608820
180Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.65854924
181Central scotoma (HP:0000603)1.64816380
182Ectropion (HP:0000656)1.64442831
183Nephroblastoma (Wilms tumor) (HP:0002667)1.63709968
184Hematochezia (HP:0002573)1.61885724
185Abnormality of the antihelix (HP:0009738)1.61559945
186Abnormality of salivation (HP:0100755)1.59355400
187Neoplasm of the tracheobronchial system (HP:0100552)1.59130621
188Exotropia (HP:0000577)1.58938497
189Tapered finger (HP:0001182)1.58808641
190Broad foot (HP:0001769)1.57626715
191Broad-based gait (HP:0002136)1.56283767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K23.79524914
2INSRR3.35561467
3PRKD32.85486716
4FRK2.82325901
5MAP3K92.78943369
6CASK2.58278578
7MAP3K62.57033707
8PKN22.50641820
9CDK192.40392962
10BCR2.36620889
11SCYL22.33317481
12PASK2.11141329
13NEK92.09435605
14NTRK31.99726734
15MAP3K41.96005373
16PTK61.93307178
17PIK3CG1.90833971
18ERBB31.87914520
19KSR21.86093962
20FLT31.84511203
21NTRK11.79715926
22TRIB31.76382053
23RET1.74840341
24MAP3K31.63632369
25FGFR41.59568320
26MAP3K51.54981470
27FGFR21.54668667
28EPHA41.53963422
29DYRK31.51471960
30ACVR1B1.49815508
31RIPK11.48718142
32LATS11.45213284
33TAOK31.43984913
34CAMKK11.41652450
35RPS6KA41.41157452
36PDGFRA1.40228653
37SIK11.39205404
38MAP2K71.38740408
39MAP3K101.37453975
40PAK61.35258206
41PRKCH1.33595705
42MAPK131.30969260
43ERN11.28655358
44MAP2K41.28534435
45YES11.28245161
46CAMK1G1.25244535
47TEC1.18666864
48CAMK1D1.18475306
49DAPK21.18264878
50TYRO31.14974778
51NEK11.14285943
52EIF2AK31.12694352
53CDK121.11832069
54MINK11.09462460
55MAP3K131.06760479
56MAP4K21.06573763
57STK31.06508834
58STK38L1.06104955
59KSR11.05625764
60WNK31.03563303
61SRPK11.02272382
62ALK1.01499146
63ICK1.00282495
64PTK21.00211194
65FGFR30.98561690
66MKNK10.95441415
67OBSCN0.92772470
68SGK30.89782433
69MARK10.89129778
70AKT30.88630186
71SIK20.88203586
72MET0.87650672
73FER0.87238227
74PAK30.86806824
75RIPK40.85946800
76MTOR0.83894256
77FES0.83620216
78HIPK20.83164780
79BMPR20.82861801
80CDC42BPA0.80726948
81MAP2K60.80157355
82EEF2K0.79392598
83RAF10.78924119
84MAP2K30.78696605
85CAMKK20.78376713
86STK240.78016478
87NLK0.76927640
88NEK60.75483419
89PRKAA10.73655563
90JAK10.72243714
91CSNK1A1L0.71675685
92CDK50.70802169
93BTK0.70515797
94PDK40.70173162
95PDK30.70173162
96FGR0.69997738
97SGK4940.66903652
98SGK2230.66903652
99MAP3K10.66884031
100EPHA30.66181661
101JAK20.65621180
102FGFR10.64984446
103BRSK10.64603731
104SGK20.63779337
105MAP3K140.63074550
106TGFBR10.62765754
107TTN0.61834312
108MARK20.61672089
109BLK0.59924503
110PNCK0.59771380
111WNK10.59753621
112ATM0.57141614
113TRIM280.56882257
114PDK10.56791896
115STK110.56756754
116SGK10.56450466
117DYRK1A0.56294164
118UHMK10.55575434
119EGFR0.55514293
120NUAK10.54718564
121PIK3CA0.53814548
122CAMK40.53701990
123BCKDK0.52454882
124CSNK1G10.52329815
125PDPK10.51778288
126NTRK20.51270534
127HCK0.51070392
128ERBB20.50924957
129MAP3K70.50121851
130RPS6KA30.49697277
131PDGFRB0.49307411
132CSF1R0.48315869
133BRD40.48226645
134PLK40.47852479
135DAPK10.46971760
136CSNK1G20.46295310
137PRKCZ0.44780397
138TYK20.44007112
139CSK0.42042356
140RPS6KB10.41814773
141KIT0.40838884
142ERBB40.40373669
143LYN0.40300003
144PINK10.39571713
145CDK60.39461139
146MAPK150.37210087
147MAPK100.36958494
148STK380.36893170
149PRKDC0.36714080
150PRKCB0.35927991
151BRSK20.35122419
152MAP2K10.35027944
153DYRK1B0.34893923
154CCNB10.34136464
155PLK20.33357864
156PRKACG0.33280136

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.53954569
2Nitrogen metabolism_Homo sapiens_hsa009103.29701564
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62348439
4Type II diabetes mellitus_Homo sapiens_hsa049302.04010219
5Arginine biosynthesis_Homo sapiens_hsa002202.02986378
6Colorectal cancer_Homo sapiens_hsa052102.02702289
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.97525040
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.96332818
9Insulin secretion_Homo sapiens_hsa049111.94580159
10Non-homologous end-joining_Homo sapiens_hsa034501.78692439
11Selenocompound metabolism_Homo sapiens_hsa004501.72500446
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67858712
13Synaptic vesicle cycle_Homo sapiens_hsa047211.63772668
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58845790
15Pancreatic cancer_Homo sapiens_hsa052121.57965741
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57894281
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57837031
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52468777
19Butanoate metabolism_Homo sapiens_hsa006501.49149039
20Chronic myeloid leukemia_Homo sapiens_hsa052201.47054898
21Sulfur metabolism_Homo sapiens_hsa009201.46292548
22FoxO signaling pathway_Homo sapiens_hsa040681.44398258
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.43193808
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42478338
25Bile secretion_Homo sapiens_hsa049761.41716732
26Adherens junction_Homo sapiens_hsa045201.39667868
27Regulation of autophagy_Homo sapiens_hsa041401.39298931
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38521576
29Choline metabolism in cancer_Homo sapiens_hsa052311.37564133
30GABAergic synapse_Homo sapiens_hsa047271.35849773
31Long-term potentiation_Homo sapiens_hsa047201.35378173
32ErbB signaling pathway_Homo sapiens_hsa040121.31867243
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30802363
34B cell receptor signaling pathway_Homo sapiens_hsa046621.30377051
35Renal cell carcinoma_Homo sapiens_hsa052111.29266812
36Acute myeloid leukemia_Homo sapiens_hsa052211.28578304
37Tryptophan metabolism_Homo sapiens_hsa003801.26069925
38Glucagon signaling pathway_Homo sapiens_hsa049221.25602675
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25446797
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24552273
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22925572
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22864073
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20308103
44Dopaminergic synapse_Homo sapiens_hsa047281.19368203
45Leishmaniasis_Homo sapiens_hsa051401.17614997
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17427315
47mTOR signaling pathway_Homo sapiens_hsa041501.16421725
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15992198
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15071001
50Tuberculosis_Homo sapiens_hsa051521.14933497
51Insulin resistance_Homo sapiens_hsa049311.14903456
52Amphetamine addiction_Homo sapiens_hsa050311.14493343
53Circadian rhythm_Homo sapiens_hsa047101.13283428
54Platelet activation_Homo sapiens_hsa046111.12200489
55Fatty acid degradation_Homo sapiens_hsa000711.10729755
56Circadian entrainment_Homo sapiens_hsa047131.09855799
57Sphingolipid signaling pathway_Homo sapiens_hsa040711.09328680
58Toxoplasmosis_Homo sapiens_hsa051451.06091593
59Estrogen signaling pathway_Homo sapiens_hsa049151.03708606
60Thyroid hormone synthesis_Homo sapiens_hsa049181.03005940
61Hepatitis B_Homo sapiens_hsa051611.02548672
62Cocaine addiction_Homo sapiens_hsa050301.01908326
63Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01850971
64Vibrio cholerae infection_Homo sapiens_hsa051101.01513213
65mRNA surveillance pathway_Homo sapiens_hsa030150.98696472
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98343230
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97942397
68MicroRNAs in cancer_Homo sapiens_hsa052060.97734550
69Prostate cancer_Homo sapiens_hsa052150.95694304
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95652855
71Cholinergic synapse_Homo sapiens_hsa047250.95498389
72Osteoclast differentiation_Homo sapiens_hsa043800.95360974
73Morphine addiction_Homo sapiens_hsa050320.93433695
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92889988
75Fatty acid metabolism_Homo sapiens_hsa012120.91375821
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91179393
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91161317
78ABC transporters_Homo sapiens_hsa020100.91071481
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90153169
80Insulin signaling pathway_Homo sapiens_hsa049100.89494614
81Renin secretion_Homo sapiens_hsa049240.86759521
82Dorso-ventral axis formation_Homo sapiens_hsa043200.86188826
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.86153062
84Olfactory transduction_Homo sapiens_hsa047400.85427611
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84225271
86Lysine degradation_Homo sapiens_hsa003100.82723390
87Complement and coagulation cascades_Homo sapiens_hsa046100.82493522
88Glutamatergic synapse_Homo sapiens_hsa047240.82155328
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81392722
90AMPK signaling pathway_Homo sapiens_hsa041520.81273586
91Glioma_Homo sapiens_hsa052140.80866864
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80548092
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80433050
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80359309
95Salivary secretion_Homo sapiens_hsa049700.80008547
96p53 signaling pathway_Homo sapiens_hsa041150.78674829
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.77910392
98Starch and sucrose metabolism_Homo sapiens_hsa005000.77193748
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76190941
100Nicotine addiction_Homo sapiens_hsa050330.76073327
101Axon guidance_Homo sapiens_hsa043600.75912831
102Biosynthesis of amino acids_Homo sapiens_hsa012300.75591228
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.75243624
104T cell receptor signaling pathway_Homo sapiens_hsa046600.73543714
105Prion diseases_Homo sapiens_hsa050200.73423944
106Fanconi anemia pathway_Homo sapiens_hsa034600.73172458
107VEGF signaling pathway_Homo sapiens_hsa043700.72794321
108Viral carcinogenesis_Homo sapiens_hsa052030.72707230
109Small cell lung cancer_Homo sapiens_hsa052220.72471718
110Gastric acid secretion_Homo sapiens_hsa049710.71505825
111Hepatitis C_Homo sapiens_hsa051600.71440712
112Lysosome_Homo sapiens_hsa041420.71360465
113Pyruvate metabolism_Homo sapiens_hsa006200.70778031
114Inositol phosphate metabolism_Homo sapiens_hsa005620.69154610
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68930787
116Pancreatic secretion_Homo sapiens_hsa049720.68923691
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68604149
118Phagosome_Homo sapiens_hsa041450.68260488
119PPAR signaling pathway_Homo sapiens_hsa033200.67831348
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.67794959
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67674233
122RNA transport_Homo sapiens_hsa030130.67077921
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66080484
124Fat digestion and absorption_Homo sapiens_hsa049750.65891680
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65490584
126Alcoholism_Homo sapiens_hsa050340.64707519
127Carbon metabolism_Homo sapiens_hsa012000.64154359
128Phototransduction_Homo sapiens_hsa047440.63489908
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63468472
130Fructose and mannose metabolism_Homo sapiens_hsa000510.60166340
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59972760
132Taste transduction_Homo sapiens_hsa047420.59574372
133Propanoate metabolism_Homo sapiens_hsa006400.58464448
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58395155
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58215725
136Type I diabetes mellitus_Homo sapiens_hsa049400.57353674
137Influenza A_Homo sapiens_hsa051640.56122745
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.55751812
139Collecting duct acid secretion_Homo sapiens_hsa049660.55691917
140Endometrial cancer_Homo sapiens_hsa052130.55473537
141Fatty acid biosynthesis_Homo sapiens_hsa000610.54971138
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.54957487
143Oxytocin signaling pathway_Homo sapiens_hsa049210.54896818
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.54269565
145Measles_Homo sapiens_hsa051620.53965148
146Basal transcription factors_Homo sapiens_hsa030220.53902365
147Ras signaling pathway_Homo sapiens_hsa040140.53784926
148Other glycan degradation_Homo sapiens_hsa005110.52894859
149Sphingolipid metabolism_Homo sapiens_hsa006000.51906656
150Rap1 signaling pathway_Homo sapiens_hsa040150.50236250
151Legionellosis_Homo sapiens_hsa051340.49830402
152GnRH signaling pathway_Homo sapiens_hsa049120.49228057
153Focal adhesion_Homo sapiens_hsa045100.49194434
154Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48908453
155Ether lipid metabolism_Homo sapiens_hsa005650.48775650
156Glycerolipid metabolism_Homo sapiens_hsa005610.48275119
157Amoebiasis_Homo sapiens_hsa051460.47770376
158HIF-1 signaling pathway_Homo sapiens_hsa040660.47587012
159Gap junction_Homo sapiens_hsa045400.47419877
160Steroid biosynthesis_Homo sapiens_hsa001000.46548481
161cAMP signaling pathway_Homo sapiens_hsa040240.46278380
162Long-term depression_Homo sapiens_hsa047300.46222508
163Herpes simplex infection_Homo sapiens_hsa051680.45469473
164Chemokine signaling pathway_Homo sapiens_hsa040620.45260078
165N-Glycan biosynthesis_Homo sapiens_hsa005100.44444383
166Prolactin signaling pathway_Homo sapiens_hsa049170.44275354
167Non-small cell lung cancer_Homo sapiens_hsa052230.43673403
168Oocyte meiosis_Homo sapiens_hsa041140.41898813
169Phenylalanine metabolism_Homo sapiens_hsa003600.38453025

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