TRAPPC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxaloacetate metabolic process (GO:0006107)4.35626946
2synaptic vesicle maturation (GO:0016188)4.29183246
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24165995
4synaptic vesicle exocytosis (GO:0016079)4.22756747
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94193896
6valine metabolic process (GO:0006573)3.87997553
7regulation of synaptic vesicle exocytosis (GO:2000300)3.86883421
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.85050755
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.71688763
10regulation of synapse structural plasticity (GO:0051823)3.69719373
11regulation of synaptic vesicle transport (GO:1902803)3.66698196
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65208221
13glutamate secretion (GO:0014047)3.61570719
14NADH metabolic process (GO:0006734)3.56299607
15activation of protein kinase A activity (GO:0034199)3.46385589
16regulation of glutamate receptor signaling pathway (GO:1900449)3.45711991
17locomotory exploration behavior (GO:0035641)3.43207999
18ncRNA 3-end processing (GO:0043628)3.39119636
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38950815
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.38950815
21ribosomal small subunit assembly (GO:0000028)3.35693216
22interkinetic nuclear migration (GO:0022027)3.30260229
23positive regulation of gamma-delta T cell activation (GO:0046645)3.29481373
24protein localization to synapse (GO:0035418)3.28189475
25antigen processing and presentation via MHC class Ib (GO:0002475)3.25042736
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.20701996
27positive regulation of CREB transcription factor activity (GO:0032793)3.17227320
28regulation of B cell receptor signaling pathway (GO:0050855)3.16883487
29neurotransmitter secretion (GO:0007269)3.15849116
30neuromuscular process controlling posture (GO:0050884)3.11678411
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.08181703
32mucosal-associated lymphoid tissue development (GO:0048537)3.07125181
33Peyers patch development (GO:0048541)3.07125181
34oxygen transport (GO:0015671)3.01868755
35tricarboxylic acid metabolic process (GO:0072350)3.01077978
36positive regulation of membrane potential (GO:0045838)2.98089258
37regulation of gamma-delta T cell differentiation (GO:0045586)2.97076376
38histone H3-K4 trimethylation (GO:0080182)2.92771185
39mannose metabolic process (GO:0006013)2.89630453
40neuronal action potential propagation (GO:0019227)2.88792803
41positive regulation of histone deacetylation (GO:0031065)2.85607564
42positive regulation of protein deacetylation (GO:0090312)2.85584161
43succinate metabolic process (GO:0006105)2.84476033
44antigen processing and presentation of endogenous antigen (GO:0019883)2.84160679
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83119480
46behavioral response to nicotine (GO:0035095)2.81840993
47regulation of female receptivity (GO:0045924)2.81048126
48positive regulation of fatty acid biosynthetic process (GO:0045723)2.79253003
49cellular potassium ion homeostasis (GO:0030007)2.77662545
50detection of light stimulus involved in visual perception (GO:0050908)2.76569688
51detection of light stimulus involved in sensory perception (GO:0050962)2.76569688
52regulation of neuronal synaptic plasticity (GO:0048168)2.76089027
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74679909
54regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73524914
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.72950218
56necroptotic process (GO:0070266)2.70745176
57snRNA transcription (GO:0009301)2.70140771
58cellular response to ethanol (GO:0071361)2.69922193
59negative regulation of cAMP-mediated signaling (GO:0043951)2.69806648
60regulation of ARF protein signal transduction (GO:0032012)2.69429628
61positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.68516909
62glucocorticoid receptor signaling pathway (GO:0042921)2.66718148
63regulation of long-term neuronal synaptic plasticity (GO:0048169)2.65375038
64synaptic transmission, glutamatergic (GO:0035249)2.64134908
65vocalization behavior (GO:0071625)2.63843536
66neurotransmitter-gated ion channel clustering (GO:0072578)2.62971328
67indolalkylamine metabolic process (GO:0006586)2.62358368
68positive regulation of synapse maturation (GO:0090129)2.61189386
69cilium or flagellum-dependent cell motility (GO:0001539)2.59362753
70ionotropic glutamate receptor signaling pathway (GO:0035235)2.56853826
71sodium ion export (GO:0071436)2.53716336
72neurotransmitter transport (GO:0006836)2.53516095
73regulation of neurotransmitter levels (GO:0001505)2.52900278
74negative regulation of microtubule polymerization (GO:0031115)2.51170577
75cerebellar Purkinje cell differentiation (GO:0021702)2.50341382
76lymph node development (GO:0048535)2.49866271
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.49088130
78regulation of postsynaptic membrane potential (GO:0060078)2.48223284
79neuromuscular process controlling balance (GO:0050885)2.47431179
80regulation of ARF GTPase activity (GO:0032312)2.46420078
81gamma-aminobutyric acid signaling pathway (GO:0007214)2.46267900
82pentose-phosphate shunt (GO:0006098)2.45463712
83indole-containing compound catabolic process (GO:0042436)2.44313817
84indolalkylamine catabolic process (GO:0046218)2.44313817
85tryptophan catabolic process (GO:0006569)2.44313817
86exploration behavior (GO:0035640)2.44218967
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.43369019
88positive regulation of B cell differentiation (GO:0045579)2.42724774
89mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.42576381
90nerve growth factor signaling pathway (GO:0038180)2.42104724
91response to histamine (GO:0034776)2.40688824
92dopamine receptor signaling pathway (GO:0007212)2.39829632
93regulation of gamma-delta T cell activation (GO:0046643)2.39521911
94T cell homeostasis (GO:0043029)2.39182206
95sodium-independent organic anion transport (GO:0043252)2.38621164
96neuron-neuron synaptic transmission (GO:0007270)2.38598168
97endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.38099492
98lactate metabolic process (GO:0006089)2.38026845
99clathrin coat assembly (GO:0048268)2.37720562
100regulation of defense response to virus by virus (GO:0050690)2.37472064
101L-fucose catabolic process (GO:0042355)2.37468034
102fucose catabolic process (GO:0019317)2.37468034
103L-fucose metabolic process (GO:0042354)2.37468034
104activated T cell proliferation (GO:0050798)2.36524899
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.35809785
106axon ensheathment in central nervous system (GO:0032291)2.35622102
107central nervous system myelination (GO:0022010)2.35622102
108calcium-mediated signaling using intracellular calcium source (GO:0035584)2.35469097
109cellular response to glucagon stimulus (GO:0071377)2.34977401
110gamma-aminobutyric acid transport (GO:0015812)2.34849401
111catecholamine transport (GO:0051937)2.34269323
112mast cell activation involved in immune response (GO:0002279)2.34105302
113mast cell degranulation (GO:0043303)2.34105302
114regulation of neurotransmitter secretion (GO:0046928)2.33543714
1152-oxoglutarate metabolic process (GO:0006103)2.32865537
116cAMP catabolic process (GO:0006198)2.32425046
117membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32037837
118positive regulation of developmental pigmentation (GO:0048087)2.30979432
119protein K48-linked deubiquitination (GO:0071108)2.30475944
120female mating behavior (GO:0060180)2.30459952
121membrane hyperpolarization (GO:0060081)2.30293743
122B cell receptor signaling pathway (GO:0050853)2.30237438
123membrane depolarization during action potential (GO:0086010)2.28851923
124NAD biosynthetic process (GO:0009435)2.28736071
125negative regulation of mast cell activation (GO:0033004)2.28157512
126positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28011204
127positive regulation of neurotransmitter transport (GO:0051590)2.27862836
128cellular ketone body metabolic process (GO:0046950)2.27139568
129striated muscle atrophy (GO:0014891)2.25697363
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.25343122
131membrane depolarization (GO:0051899)2.25284554
132negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24347153
133cellular extravasation (GO:0045123)2.24218271
134neurotransmitter uptake (GO:0001504)2.23559121
135corticosteroid receptor signaling pathway (GO:0031958)2.23462429
136synaptic vesicle endocytosis (GO:0048488)2.23112190
137adenosine receptor signaling pathway (GO:0001973)2.22842369
138phosphatidylglycerol biosynthetic process (GO:0006655)2.21678599
139positive regulation of triglyceride biosynthetic process (GO:0010867)2.21597964
140regulation of histone deacetylation (GO:0031063)2.20702655
141opioid receptor signaling pathway (GO:0038003)2.19814171
142positive regulation of Rab GTPase activity (GO:0032851)2.17389816
143regulation of Rab GTPase activity (GO:0032313)2.17389816
144regulation of MHC class I biosynthetic process (GO:0045343)2.16653042
145skeletal muscle adaptation (GO:0043501)2.15081430
146motile cilium assembly (GO:0044458)2.14682578
147pericardium development (GO:0060039)2.14322498
148positive regulation of fatty acid beta-oxidation (GO:0032000)2.13786665
149cellular response to exogenous dsRNA (GO:0071360)2.13699904
150negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.11513622
151protein targeting to lysosome (GO:0006622)2.11504718
152establishment of protein localization to vacuole (GO:0072666)2.11504718
153protein targeting to vacuole (GO:0006623)2.11504718
154startle response (GO:0001964)2.09949375
155cyclic nucleotide catabolic process (GO:0009214)2.09936144
156negative regulation of cell killing (GO:0031342)2.09540219
157negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.09540219
158negative regulation of calcium ion transport into cytosol (GO:0010523)2.09064972
159monoubiquitinated protein deubiquitination (GO:0035520)2.08634726
160positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.06541068
161positive regulation of fatty acid oxidation (GO:0046321)2.05591421
162neuronal action potential (GO:0019228)2.03623196
163establishment of protein localization to Golgi (GO:0072600)2.02997571
164regulation of fatty acid beta-oxidation (GO:0031998)2.00531502
165lytic vacuole organization (GO:0080171)1.99504932
166lysosome organization (GO:0007040)1.99504932
167myofibril assembly (GO:0030239)1.99353102
168regulation of cilium assembly (GO:1902017)1.99246586
169negative regulation of granulocyte differentiation (GO:0030853)1.98985198
170regulation of hydrogen peroxide metabolic process (GO:0010310)1.98939641
171phospholipid translocation (GO:0045332)1.98178998
172lipid translocation (GO:0034204)1.98178998
173tryptophan metabolic process (GO:0006568)1.97582577
174primary amino compound metabolic process (GO:1901160)1.97476593
175regulation of protein deacetylation (GO:0090311)1.96845177
176phosphatidylethanolamine biosynthetic process (GO:0006646)1.96799259
177lymphangiogenesis (GO:0001946)1.96598034
178negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)1.96155474
179negative regulation of T-helper cell differentiation (GO:0045623)1.96155474
180positive regulation of phosphatase activity (GO:0010922)1.95780245
181transmission of nerve impulse (GO:0019226)1.94795936
182mature B cell differentiation (GO:0002335)1.94650055
183positive regulation of protein kinase C signaling (GO:0090037)1.94151813
184negative regulation of erythrocyte differentiation (GO:0045647)1.93484114
185skeletal muscle tissue regeneration (GO:0043403)1.92805891
186nucleus localization (GO:0051647)1.92188144
187regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)1.91954681
188regulation of action potential (GO:0098900)1.91669802
189negative regulation of myotube differentiation (GO:0010832)1.91648617
190indole-containing compound metabolic process (GO:0042430)1.90284407
191regulation of cAMP-mediated signaling (GO:0043949)1.89911110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.46890477
2SCL_19346495_ChIP-Seq_HPC-7_Human3.30262573
3MYC_22102868_ChIP-Seq_BL_Human3.07560284
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71910740
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54384997
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52403074
7GATA1_22025678_ChIP-Seq_K562_Human2.50177404
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.48022124
9CIITA_25753668_ChIP-Seq_RAJI_Human2.45037925
10E2F7_22180533_ChIP-Seq_HELA_Human2.35305892
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.27575060
12ZNF274_21170338_ChIP-Seq_K562_Hela2.23932554
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.16328492
14GATA1_19941827_ChIP-Seq_MEL_Mouse2.14131973
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04713684
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02501168
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01586759
18GBX2_23144817_ChIP-Seq_PC3_Human1.94476047
19EZH2_22144423_ChIP-Seq_EOC_Human1.92414011
20VDR_21846776_ChIP-Seq_THP-1_Human1.91807285
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91394153
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91285876
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.90497199
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89952282
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89809856
26SPI1_23127762_ChIP-Seq_K562_Human1.83759779
27TCF7_22412390_ChIP-Seq_EML_Mouse1.82815731
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.73692299
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69321707
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67633914
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67068323
32REST_21632747_ChIP-Seq_MESCs_Mouse1.65332052
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65008029
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62922165
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60383922
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59222532
37KDM2B_26808549_Chip-Seq_DND41_Human1.58341692
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57477726
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56992537
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55085536
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52763745
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.52537025
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52418786
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52374831
45GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51339013
46LXR_22292898_ChIP-Seq_THP-1_Human1.48888215
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48711364
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48129331
49UTX_26944678_Chip-Seq_JUKART_Human1.45685368
50RUNX_20019798_ChIP-Seq_JUKART_Human1.45217910
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44753893
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44328680
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44203547
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43460821
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43151739
56AR_21572438_ChIP-Seq_LNCaP_Human1.42345887
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40542050
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40174927
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39487656
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39312905
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38624981
62VDR_24763502_ChIP-Seq_THP-1_Human1.38402123
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.38312817
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37462156
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37430203
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.36420161
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35757880
68MAF_26560356_Chip-Seq_TH1_Human1.34429815
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31923094
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30268623
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29833632
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29549549
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27792455
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27345628
75FOXP3_21729870_ChIP-Seq_TREG_Human1.27269894
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27229036
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25485660
78BCL6_27268052_Chip-Seq_Bcells_Human1.25174762
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24582555
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.23392644
81SMC4_20622854_ChIP-Seq_HELA_Human1.23166054
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21764657
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21686199
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19656926
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19656926
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19082597
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19045373
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18952030
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18061808
90DROSHA_22980978_ChIP-Seq_HELA_Human1.17585349
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16414263
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16263806
93TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14344956
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14206194
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13663622
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13447884
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13143166
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12806590
99BCOR_27268052_Chip-Seq_Bcells_Human1.12495771
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11807321
101OCT4_19829295_ChIP-Seq_ESCs_Human1.11380407
102CTCF_27219007_Chip-Seq_Bcells_Human1.11325572
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11214317
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10989477
105P68_20966046_ChIP-Seq_HELA_Human1.10536694
106TP53_16413492_ChIP-PET_HCT116_Human1.10195218
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09847704
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09327044
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07779573
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07779573
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06867678
112CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06589683
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05772258
114ZNF263_19887448_ChIP-Seq_K562_Human1.05651803
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05549611
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05002340
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04095217
118ETS1_20019798_ChIP-Seq_JURKAT_Human1.02487513
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01495697
120AHR_22903824_ChIP-Seq_MCF-7_Human1.01252084
121EZH2_27304074_Chip-Seq_ESCs_Mouse1.01193083
122MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01012252
123VDR_24787735_ChIP-Seq_THP-1_Human1.00703711
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00660913
125STAT3_23295773_ChIP-Seq_U87_Human1.00551308
126AR_19668381_ChIP-Seq_PC3_Human0.99868157
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99644863
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99308964
129MAF_26560356_Chip-Seq_TH2_Human0.99257507
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98665335
131MYB_26560356_Chip-Seq_TH1_Human0.98451977
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98442532
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.98345015
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.98044081
135BCAT_22108803_ChIP-Seq_LS180_Human0.97540669
136EED_16625203_ChIP-ChIP_MESCs_Mouse0.97453204
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96063492
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.95735205
139GATA1_26923725_Chip-Seq_HPCs_Mouse0.95508463
140KDM2B_26808549_Chip-Seq_K562_Human0.95007760
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.94640081
142NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94048293
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93930532
144GABP_19822575_ChIP-Seq_HepG2_Human0.93739158
145IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93682766
146TP63_22573176_ChIP-Seq_HFKS_Human0.93319587
147PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93046580
148KLF4_19829295_ChIP-Seq_ESCs_Human0.93023997
149TCF4_23295773_ChIP-Seq_U87_Human0.92461041
150* SPI1_23547873_ChIP-Seq_NB4_Human0.91970669
151MYB_26560356_Chip-Seq_TH2_Human0.91896288
152PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90606701
153ERA_21632823_ChIP-Seq_H3396_Human0.87687684
154RXR_22108803_ChIP-Seq_LS180_Human0.86945158
155IRF8_27001747_Chip-Seq_BMDM_Mouse0.84917630
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84146355
157TP53_23651856_ChIP-Seq_MEFs_Mouse0.83012420
158GATA1_19941826_ChIP-Seq_K562_Human0.82593735
159ERG_21242973_ChIP-ChIP_JURKAT_Human0.82588203
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.82113107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.63254425
2MP0003646_muscle_fatigue3.42475011
3MP0002653_abnormal_ependyma_morphology3.25067923
4MP0003880_abnormal_central_pattern3.12925169
5MP0003635_abnormal_synaptic_transmissio3.07320480
6MP0002822_catalepsy2.78533850
7MP0009745_abnormal_behavioral_response2.57362856
8MP0002064_seizures2.56464999
9MP0001968_abnormal_touch/_nociception2.43813568
10MP0002736_abnormal_nociception_after2.35462705
11MP0004270_analgesia2.29804141
12MP0009046_muscle_twitch2.24094030
13MP0008872_abnormal_physiological_respon2.22764551
14MP0003656_abnormal_erythrocyte_physiolo2.17120638
15MP0002272_abnormal_nervous_system2.12532788
16MP0002063_abnormal_learning/memory/cond2.03619174
17MP0005670_abnormal_white_adipose1.98176551
18MP0003329_amyloid_beta_deposits1.94231054
19MP0002928_abnormal_bile_duct1.86971740
20MP0001545_abnormal_hematopoietic_system1.86472358
21MP0005397_hematopoietic_system_phenotyp1.86472358
22MP0004381_abnormal_hair_follicle1.85693934
23MP0003172_abnormal_lysosome_physiology1.82412046
24MP0006276_abnormal_autonomic_nervous1.80893727
25MP0005409_darkened_coat_color1.80839042
26MP0002572_abnormal_emotion/affect_behav1.79689977
27MP0002909_abnormal_adrenal_gland1.78987290
28MP0004147_increased_porphyrin_level1.77992983
29MP0002396_abnormal_hematopoietic_system1.76499767
30MP0004145_abnormal_muscle_electrophysio1.69511989
31MP0002735_abnormal_chemical_nociception1.65709096
32MP0005423_abnormal_somatic_nervous1.63791580
33MP0003045_fibrosis1.62478147
34MP0005365_abnormal_bile_salt1.61131426
35MP0003787_abnormal_imprinting1.59119570
36MP0003195_calcinosis1.58092142
37MP0004811_abnormal_neuron_physiology1.54691605
38MP0002734_abnormal_mechanical_nocicepti1.53990586
39MP0005646_abnormal_pituitary_gland1.50456146
40MP0008569_lethality_at_weaning1.49767716
41MP0001800_abnormal_humoral_immune1.46670272
42MP0006036_abnormal_mitochondrial_physio1.44860166
43MP0000685_abnormal_immune_system1.42696576
44MP0004043_abnormal_pH_regulation1.39493832
45MP0001790_abnormal_immune_system1.38009223
46MP0005387_immune_system_phenotype1.38009223
47MP0005584_abnormal_enzyme/coenzyme_acti1.37594122
48MP0005310_abnormal_salivary_gland1.34885091
49MP0004924_abnormal_behavior1.31980386
50MP0005386_behavior/neurological_phenoty1.31980386
51MP0008874_decreased_physiological_sensi1.31257276
52MP0002139_abnormal_hepatobiliary_system1.30292200
53MP0003763_abnormal_thymus_physiology1.30197853
54MP0004808_abnormal_hematopoietic_stem1.29902165
55MP0001970_abnormal_pain_threshold1.29488189
56MP0001486_abnormal_startle_reflex1.29278988
57MP0009840_abnormal_foam_cell1.29050749
58MP0000747_muscle_weakness1.28787467
59MP0000604_amyloidosis1.28066610
60MP0000230_abnormal_systemic_arterial1.26477601
61MP0003436_decreased_susceptibility_to1.23725115
62MP0003878_abnormal_ear_physiology1.23483392
63MP0005377_hearing/vestibular/ear_phenot1.23483392
64MP0002067_abnormal_sensory_capabilities1.21541197
65MP0003183_abnormal_peptide_metabolism1.21003696
66MP0005645_abnormal_hypothalamus_physiol1.21002285
67MP0005464_abnormal_platelet_physiology1.20933892
68MP0002733_abnormal_thermal_nociception1.20033488
69MP0000751_myopathy1.19960208
70MP0000569_abnormal_digit_pigmentation1.16742904
71MP0002138_abnormal_hepatobiliary_system1.15117490
72MP0003633_abnormal_nervous_system1.15029226
73MP0005058_abnormal_lysosome_morphology1.14026835
74MP0001873_stomach_inflammation1.13216300
75MP0005167_abnormal_blood-brain_barrier1.13146788
76MP0001986_abnormal_taste_sensitivity1.11803986
77MP0003866_abnormal_defecation1.11269933
78MP0004142_abnormal_muscle_tone1.11186769
79MP0004742_abnormal_vestibular_system1.10518051
80MP0000015_abnormal_ear_pigmentation1.08521118
81MP0002398_abnormal_bone_marrow1.08180376
82MP0004036_abnormal_muscle_relaxation1.06114759
83MP0000371_diluted_coat_color1.05556626
84MP0000013_abnormal_adipose_tissue1.05414811
85MP0001529_abnormal_vocalization1.05267330
86MP0003868_abnormal_feces_composition1.05174034
87MP0009278_abnormal_bone_marrow1.03713753
88MP0005535_abnormal_body_temperature1.02174085
89MP0001348_abnormal_lacrimal_gland1.01597769
90MP0000465_gastrointestinal_hemorrhage1.01398395
91MP0002229_neurodegeneration0.99824826
92MP0003724_increased_susceptibility_to0.99795685
93MP0002419_abnormal_innate_immunity0.98139174
94MP0006035_abnormal_mitochondrial_morpho0.97725137
95MP0003879_abnormal_hair_cell0.97017843
96MP0002971_abnormal_brown_adipose0.96128280
97MP0002933_joint_inflammation0.95762186
98MP0001502_abnormal_circadian_rhythm0.95450456
99MP0002066_abnormal_motor_capabilities/c0.94617752
100MP0008877_abnormal_DNA_methylation0.94417623
101MP0002837_dystrophic_cardiac_calcinosis0.94208113
102MP0002168_other_aberrant_phenotype0.93700124
103MP0002723_abnormal_immune_serum0.93271812
104MP0000703_abnormal_thymus_morphology0.92895630
105MP0004130_abnormal_muscle_cell0.92410526
106MP0003221_abnormal_cardiomyocyte_apopto0.92256398
107MP0001501_abnormal_sleep_pattern0.91866266
108MP0005025_abnormal_response_to0.91701537
109MP0005360_urolithiasis0.90604237
110MP0009384_cardiac_valve_regurgitation0.90556372
111MP0004885_abnormal_endolymph0.90090995
112MP0002557_abnormal_social/conspecific_i0.89077377
113MP0000689_abnormal_spleen_morphology0.88916039
114MP0001958_emphysema0.87918166
115MP0000920_abnormal_myelination0.87515710
116MP0005551_abnormal_eye_electrophysiolog0.87472053
117MP0005174_abnormal_tail_pigmentation0.86885804
118MP0003631_nervous_system_phenotype0.86516905
119MP0001905_abnormal_dopamine_level0.85453683
120MP0002166_altered_tumor_susceptibility0.83452604
121MP0002722_abnormal_immune_system0.83216928
122MP0002420_abnormal_adaptive_immunity0.83118251
123MP0002882_abnormal_neuron_morphology0.82920134
124MP0003075_altered_response_to0.82820779
125MP0003690_abnormal_glial_cell0.82503780
126MP0005166_decreased_susceptibility_to0.82244575
127MP0002452_abnormal_antigen_presenting0.80941872
128MP0000470_abnormal_stomach_morphology0.80771560
129MP0000955_abnormal_spinal_cord0.80768413
130MP0001819_abnormal_immune_cell0.79306882
131MP0001765_abnormal_ion_homeostasis0.78997657
132MP0001835_abnormal_antigen_presentation0.78687876
133MP0003806_abnormal_nucleotide_metabolis0.78073386
134MP0001764_abnormal_homeostasis0.77400660
135MP0008961_abnormal_basal_metabolism0.76626378
136MP0005448_abnormal_energy_balance0.76581345
137MP0010329_abnormal_lipoprotein_level0.75722039
138MP0005266_abnormal_metabolism0.74865040
139MP0002118_abnormal_lipid_homeostasis0.74838751
140MP0005075_abnormal_melanosome_morpholog0.74516915
141MP0004133_heterotaxia0.74048402
142MP0001663_abnormal_digestive_system0.74032682
143MP0000716_abnormal_immune_system0.73324297
144MP0003303_peritoneal_inflammation0.73170949
145MP0005000_abnormal_immune_tolerance0.72893736
146MP0001963_abnormal_hearing_physiology0.72679238
147MP0002405_respiratory_system_inflammati0.72027130
148MP0004858_abnormal_nervous_system0.71599551
149MP0002693_abnormal_pancreas_physiology0.70664661
150MP0003943_abnormal_hepatobiliary_system0.70108127

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.55229213
2Myokymia (HP:0002411)4.23090523
3Ankle clonus (HP:0011448)4.21358184
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.06842356
5Absent/shortened dynein arms (HP:0200106)4.06842356
6Hyperventilation (HP:0002883)3.81705641
7Thrombocytosis (HP:0001894)3.75410607
8Impaired vibration sensation in the lower limbs (HP:0002166)3.69328329
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.65339012
10Progressive cerebellar ataxia (HP:0002073)3.59128623
11Visual hallucinations (HP:0002367)3.56097908
12Spastic gait (HP:0002064)3.51255122
13Clonus (HP:0002169)3.35412452
14Papilledema (HP:0001085)3.25852328
15Focal motor seizures (HP:0011153)3.06432054
16Protruding tongue (HP:0010808)3.04853077
17Epileptic encephalopathy (HP:0200134)2.99358947
18Abnormality of the heme biosynthetic pathway (HP:0010472)2.97630107
19Clumsiness (HP:0002312)2.95420035
20Fatigue (HP:0012378)2.90149968
21Postural instability (HP:0002172)2.87367436
22Febrile seizures (HP:0002373)2.85065945
23Abnormal ciliary motility (HP:0012262)2.84460594
24Abnormal respiratory epithelium morphology (HP:0012253)2.83535240
25Abnormal respiratory motile cilium morphology (HP:0005938)2.83535240
26Supranuclear gaze palsy (HP:0000605)2.80222439
27Abnormality of the periventricular white matter (HP:0002518)2.75992584
28Anxiety (HP:0000739)2.75515460
29Aplastic anemia (HP:0001915)2.73581046
30Impaired vibratory sensation (HP:0002495)2.70861778
31Resting tremor (HP:0002322)2.65553255
32Abnormality of fatty-acid metabolism (HP:0004359)2.65166495
33Urinary urgency (HP:0000012)2.64404113
34Hypoplasia of the thymus (HP:0000778)2.59914872
35Congenital stationary night blindness (HP:0007642)2.54810753
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.52300808
37Depression (HP:0000716)2.49079917
38Focal seizures (HP:0007359)2.48387435
39Nephronophthisis (HP:0000090)2.47972195
40Bony spicule pigmentary retinopathy (HP:0007737)2.47534823
41Lower limb muscle weakness (HP:0007340)2.43865066
42Impaired social interactions (HP:0000735)2.40911956
43Abnormal social behavior (HP:0012433)2.40911956
44Truncal ataxia (HP:0002078)2.38601128
45Death in childhood (HP:0003819)2.37346702
46Chronic hepatic failure (HP:0100626)2.36144852
47Chronic otitis media (HP:0000389)2.35526228
48Poor eye contact (HP:0000817)2.35510771
49Myositis (HP:0100614)2.34656288
50Molar tooth sign on MRI (HP:0002419)2.33478653
51Abnormality of midbrain morphology (HP:0002418)2.33478653
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.32482348
53Abnormal drinking behavior (HP:0030082)2.31782220
54Polydipsia (HP:0001959)2.31782220
55Scanning speech (HP:0002168)2.31326768
56Urinary bladder sphincter dysfunction (HP:0002839)2.31190414
57Attenuation of retinal blood vessels (HP:0007843)2.29746176
58Insomnia (HP:0100785)2.29376717
59Abnormality of the lower motor neuron (HP:0002366)2.27542479
60Decreased circulating renin level (HP:0003351)2.27508701
61Recurrent fungal infections (HP:0002841)2.25489971
62Abnormality of the fingertips (HP:0001211)2.24752456
63Recurrent sinusitis (HP:0011108)2.24589808
64Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23743530
65Bradykinesia (HP:0002067)2.22612893
66Poor suck (HP:0002033)2.22254046
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.21443752
68Focal dystonia (HP:0004373)2.20124396
69Macroglossia (HP:0000158)2.17466330
70Abnormality of the renal medulla (HP:0100957)2.17061892
71Tetraplegia (HP:0002445)2.15279393
72Dysmetria (HP:0001310)2.14442992
73Craniofacial dystonia (HP:0012179)2.13911707
74Cystic liver disease (HP:0006706)2.13632015
75Obstructive sleep apnea (HP:0002870)2.13608716
76Bulbous nose (HP:0000414)2.12834911
77Orchitis (HP:0100796)2.11413277
78Elevated erythrocyte sedimentation rate (HP:0003565)2.10347259
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10145006
80Abnormality of ocular smooth pursuit (HP:0000617)2.09864809
81Nasal polyposis (HP:0100582)2.09462796
82Keratoconjunctivitis (HP:0001096)2.06986013
83Cholecystitis (HP:0001082)2.05889145
84Abnormal gallbladder physiology (HP:0012438)2.05889145
85Gaze-evoked nystagmus (HP:0000640)2.04537223
86Progressive microcephaly (HP:0000253)2.03353624
87Increased variability in muscle fiber diameter (HP:0003557)2.03062618
88Keratoconjunctivitis sicca (HP:0001097)2.01235635
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00794650
90Psychosis (HP:0000709)1.99239525
91Severe global developmental delay (HP:0011344)1.98498117
92Absent speech (HP:0001344)1.98366469
93Prolonged QT interval (HP:0001657)1.97741393
94Hyperacusis (HP:0010780)1.97126446
95Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96924464
96Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96924464
97Abnormality of polysaccharide metabolism (HP:0011012)1.96924464
98Epileptiform EEG discharges (HP:0011182)1.95463337
99Colitis (HP:0002583)1.95382615
100Lymphangioma (HP:0100764)1.94546946
101Rigidity (HP:0002063)1.94473748
102CNS hypomyelination (HP:0003429)1.94410125
103EEG with generalized epileptiform discharges (HP:0011198)1.94394208
104Recurrent bronchitis (HP:0002837)1.93738338
105Abnormality of binocular vision (HP:0011514)1.90443775
106Diplopia (HP:0000651)1.90443775
107Ragged-red muscle fibers (HP:0003200)1.89817865
108Increased cerebral lipofuscin (HP:0011813)1.89762301
109Retrobulbar optic neuritis (HP:0100654)1.89728021
110Optic neuritis (HP:0100653)1.89728021
111Menstrual irregularities (HP:0000858)1.88955517
112Polygenic inheritance (HP:0010982)1.88905456
113Spontaneous hematomas (HP:0007420)1.87640246
114Generalized tonic-clonic seizures (HP:0002069)1.87637194
115Torticollis (HP:0000473)1.87578529
116Hyperkalemia (HP:0002153)1.87415562
117Growth hormone excess (HP:0000845)1.87193640
118Exercise-induced myalgia (HP:0003738)1.86879085
119Hypoplastic ischia (HP:0003175)1.86739005
120Decreased central vision (HP:0007663)1.86725168
121Recurrent cutaneous fungal infections (HP:0011370)1.86525940
122Chronic mucocutaneous candidiasis (HP:0002728)1.86525940
123Mucopolysacchariduria (HP:0008155)1.86097224
124Urinary glycosaminoglycan excretion (HP:0003541)1.86097224
125Abnormality of pain sensation (HP:0010832)1.85875621
126Impaired pain sensation (HP:0007328)1.85875621
127Impaired smooth pursuit (HP:0007772)1.85757457
128Stereotypic behavior (HP:0000733)1.84975381
129Hypsarrhythmia (HP:0002521)1.84882628
130Widely spaced teeth (HP:0000687)1.84110435
131Pancreatic cysts (HP:0001737)1.84002080
132Mesangial abnormality (HP:0001966)1.83763247
133IgM deficiency (HP:0002850)1.83435014
134Abnormal respiratory motile cilium physiology (HP:0012261)1.83006968
135Insidious onset (HP:0003587)1.82952843
136Termporal pattern (HP:0011008)1.82952843
137Abnormality of the corticospinal tract (HP:0002492)1.82949014
138Inflammation of the large intestine (HP:0002037)1.82933416
139Peritonitis (HP:0002586)1.82378612
140Ankyloglossia (HP:0010296)1.82171886
141Neonatal hypoglycemia (HP:0001998)1.82008142
142Congenital sensorineural hearing impairment (HP:0008527)1.81416279
143Hypoglycemic coma (HP:0001325)1.81244539
144Cortical visual impairment (HP:0100704)1.81227057
145Dysmetric saccades (HP:0000641)1.81123575
146Dysostosis multiplex (HP:0000943)1.81001545
147Atonic seizures (HP:0010819)1.80997335
148Progressive inability to walk (HP:0002505)1.80145283
149Abnormality of the nasal mucosa (HP:0000433)1.79879280
150Tapered finger (HP:0001182)1.79429835
151Abnormality of skeletal muscle fiber size (HP:0012084)1.79328264
152Panhypogammaglobulinemia (HP:0003139)1.79104132
153Delusions (HP:0000746)1.78826860
154Annular pancreas (HP:0001734)1.78084075
155Brushfield spots (HP:0001088)1.77823884
156Abnormality of oral frenula (HP:0000190)1.77498532
157Tented upper lip vermilion (HP:0010804)1.77321839
158Cerebral hypomyelination (HP:0006808)1.77002401
159Pigmentary retinal degeneration (HP:0001146)1.76982493
160Portal hypertension (HP:0001409)1.76684454
161Abnormality of the hepatic vasculature (HP:0006707)1.76106309
162Anomalous pulmonary venous return (HP:0010772)1.76038676
163Hemiplegia (HP:0002301)1.75806191
164Increased neuronal autofluorescent lipopigment (HP:0002074)1.75613978
165Absence seizures (HP:0002121)1.75565121
166Congenital hepatic fibrosis (HP:0002612)1.74819617
167Asymmetric septal hypertrophy (HP:0001670)1.74082224
168Abnormal rod and cone electroretinograms (HP:0008323)1.74073655
169Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74072939
170Agammaglobulinemia (HP:0004432)1.73581397
171True hermaphroditism (HP:0010459)1.73127126
172Tubular atrophy (HP:0000092)1.73114814
173Intellectual disability, severe (HP:0010864)1.72912866
174Acute lymphatic leukemia (HP:0006721)1.72803658
175Generalized aminoaciduria (HP:0002909)1.72355071
176Inability to walk (HP:0002540)1.71795888
177Keratoconus (HP:0000563)1.71568216
178Increased corneal curvature (HP:0100692)1.71568216
179Ketosis (HP:0001946)1.71527521
180Recurrent bacterial skin infections (HP:0005406)1.71397462
181Eczematoid dermatitis (HP:0000976)1.71261874
182Oligomenorrhea (HP:0000876)1.71105345
183Hypoplasia of the pons (HP:0012110)1.70843027
184Broad-based gait (HP:0002136)1.70438981
185Action tremor (HP:0002345)1.69067349
186Hyperbilirubinemia (HP:0002904)1.67970426
187Gastrointestinal inflammation (HP:0004386)1.66536960
188Truncal obesity (HP:0001956)1.66266432
189Agitation (HP:0000713)1.64931586
190Pancreatic fibrosis (HP:0100732)1.63875619
191Abnormal EKG (HP:0003115)1.63503924
192Prolonged bleeding time (HP:0003010)1.62962454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.90839371
2FRK4.71149290
3MAP2K74.61511920
4MAP2K43.49111866
5MAP4K12.75178624
6NTRK32.60189101
7CDK192.46593772
8BLK2.11732278
9MAP3K92.10900797
10EPHA42.10106237
11CAMKK22.08321667
12MINK11.89770677
13BCKDK1.86739639
14CAMK1D1.79701551
15CCNB11.75679844
16DAPK11.75317178
17CDC42BPA1.69374331
18CAMKK11.67856846
19RET1.59413314
20CAMK1G1.58021203
21CDK81.57785194
22EEF2K1.57459822
23DAPK21.57047876
24MAP3K121.56956734
25FES1.56659989
26MAP3K131.48933897
27MAP3K111.35115175
28MAPK131.34022767
29ZAP701.33785786
30PRKD31.32713343
31STK161.30595131
32INSRR1.24420410
33MAP2K21.23279202
34TSSK61.17978541
35TNK21.17436833
36SYK1.16727475
37NTRK21.16524072
38MAPK121.15988163
39ADRBK21.12555352
40TAOK31.11484676
41TAOK11.10119754
42BTK1.09750376
43KSR21.08330700
44CAMK11.07554541
45MAPK151.07065638
46TXK1.04747995
47STK381.04218792
48CDK51.03380372
49PIK3CG1.02737150
50CDK31.02084711
51FLT31.01043391
52PKN21.00994341
53PDK11.00715178
54GRK61.00580273
55TYK20.97287553
56SGK20.96131659
57RPS6KA20.95992137
58CDK120.93766853
59RPS6KA60.93443057
60MAP2K60.89676047
61KIT0.88392262
62PRKCH0.88082374
63PRKAA20.86699295
64UHMK10.84831467
65MAP3K60.83112546
66NEK10.82321768
67TYRO30.81693462
68ADRBK10.81285729
69CSF1R0.80367639
70PASK0.79849386
71SGK30.79651028
72SIK20.79298464
73RPS6KC10.78688829
74RPS6KL10.78688829
75ACVR1B0.77756871
76IRAK40.77596752
77CSNK1G30.75628062
78PAK60.75107656
79SCYL20.74355224
80JAK20.73758798
81TRIB30.73463063
82ICK0.73348388
83OBSCN0.73163879
84NTRK10.70926333
85EIF2AK10.70708151
86PDK30.69397712
87PDK40.69397712
88MAPKAPK30.68878541
89ALK0.68589331
90EPHB10.67339208
91ITK0.67157411
92MAP3K70.66858602
93MARK20.66667977
94MAPK110.65733044
95MUSK0.65380411
96IRAK10.65021961
97PTK60.64174483
98RAF10.63248869
99MAP2K30.62842297
100MAPK70.62081012
101LMTK20.62064242
102FGFR30.62062899
103TTN0.61941298
104CAMK40.61372682
105GRK10.60913407
106WNK40.59900798
107CSNK1G20.59281880
108MTOR0.59150225
109PRKAA10.58621178
110PRKCZ0.58416314
111PRKCQ0.58145543
112MAP2K10.57373691
113KSR10.57280969
114WNK10.56700200
115TGFBR10.56629381
116EPHA30.56472721
117PINK10.55767521
118SGK10.55028334
119HCK0.54729313
120WEE10.54555051
121CSK0.54141458
122PDPK10.54137969
123JAK30.53369124
124PKN10.53336442
125DYRK1B0.51911250
126SIK10.51660209
127HIPK20.51602559
128MAPK40.51215100
129RIPK40.50543664
130PAK30.49864554
131PIK3CA0.49849653
132CHUK0.49835142
133MARK10.45705889
134CSNK1A1L0.45344053
135PRKD20.45251810
136OXSR10.44347735
137LCK0.43594828
138MYLK0.43209337
139FYN0.42950848
140PRKCG0.42757309
141SGK2230.42246535
142SGK4940.42246535
143TNIK0.42138852
144PTK2B0.41571924
145CDK150.39649190
146CDK140.39570328
147ERN10.39275372
148CDK180.37990538
149MAP3K10.34561246
150STK110.33584199
151ATR0.33509691

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.93809943
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43474454
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42402080
4Nitrogen metabolism_Homo sapiens_hsa009102.37668650
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35487531
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34701723
7Circadian entrainment_Homo sapiens_hsa047132.22842488
8Long-term potentiation_Homo sapiens_hsa047202.19297903
9Olfactory transduction_Homo sapiens_hsa047402.18665687
10GABAergic synapse_Homo sapiens_hsa047272.17946707
11Nicotine addiction_Homo sapiens_hsa050332.14078490
12Morphine addiction_Homo sapiens_hsa050322.09822740
13Dopaminergic synapse_Homo sapiens_hsa047282.05065580
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01525862
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92226481
16Insulin secretion_Homo sapiens_hsa049111.91275462
17Amphetamine addiction_Homo sapiens_hsa050311.88942692
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84602050
19Glutamatergic synapse_Homo sapiens_hsa047241.75379092
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.67963950
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.63124535
22Pyruvate metabolism_Homo sapiens_hsa006201.52616889
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51126077
24Cholinergic synapse_Homo sapiens_hsa047251.49615665
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49114521
26Renin secretion_Homo sapiens_hsa049241.47738751
27N-Glycan biosynthesis_Homo sapiens_hsa005101.45210689
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43821564
29Salivary secretion_Homo sapiens_hsa049701.42177667
30Linoleic acid metabolism_Homo sapiens_hsa005911.40978412
31DNA replication_Homo sapiens_hsa030301.40399668
32Gastric acid secretion_Homo sapiens_hsa049711.31553795
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.30662832
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30483424
35Oxytocin signaling pathway_Homo sapiens_hsa049211.27859696
36Phototransduction_Homo sapiens_hsa047441.27570253
37Ovarian steroidogenesis_Homo sapiens_hsa049131.26094601
38Ether lipid metabolism_Homo sapiens_hsa005651.25056164
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24391015
40Biosynthesis of amino acids_Homo sapiens_hsa012301.22930277
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.21362299
42Type II diabetes mellitus_Homo sapiens_hsa049301.18291976
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.17466584
44Calcium signaling pathway_Homo sapiens_hsa040201.17245663
45Dorso-ventral axis formation_Homo sapiens_hsa043201.16862191
46Staphylococcus aureus infection_Homo sapiens_hsa051501.16491438
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15650836
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15535846
49GnRH signaling pathway_Homo sapiens_hsa049121.14481511
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13285493
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13017694
52Pentose phosphate pathway_Homo sapiens_hsa000301.11864716
53Oocyte meiosis_Homo sapiens_hsa041141.09721442
54Mismatch repair_Homo sapiens_hsa034301.09713722
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08137542
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08088606
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07043852
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07024201
59Osteoclast differentiation_Homo sapiens_hsa043801.06912533
60Propanoate metabolism_Homo sapiens_hsa006401.04248985
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03719872
62Cocaine addiction_Homo sapiens_hsa050301.03184979
63Notch signaling pathway_Homo sapiens_hsa043301.02820938
64Carbon metabolism_Homo sapiens_hsa012001.01990930
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01258272
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00359174
67Sulfur relay system_Homo sapiens_hsa041220.99111282
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99080587
69Lysine degradation_Homo sapiens_hsa003100.96371384
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94513246
71Glucagon signaling pathway_Homo sapiens_hsa049220.94272806
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93008790
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92542021
74Taste transduction_Homo sapiens_hsa047420.92325649
75VEGF signaling pathway_Homo sapiens_hsa043700.92163179
76B cell receptor signaling pathway_Homo sapiens_hsa046620.91362642
77Arachidonic acid metabolism_Homo sapiens_hsa005900.90049387
78Long-term depression_Homo sapiens_hsa047300.89381238
79Histidine metabolism_Homo sapiens_hsa003400.88474799
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.88236869
81Platelet activation_Homo sapiens_hsa046110.87995023
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85786182
83Bile secretion_Homo sapiens_hsa049760.82635343
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82564178
85cAMP signaling pathway_Homo sapiens_hsa040240.81417543
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.81168402
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80144511
88T cell receptor signaling pathway_Homo sapiens_hsa046600.79688076
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.79677530
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.79013972
91Acute myeloid leukemia_Homo sapiens_hsa052210.78810543
92Prolactin signaling pathway_Homo sapiens_hsa049170.77164865
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.76975868
94Fatty acid elongation_Homo sapiens_hsa000620.72664157
95Tryptophan metabolism_Homo sapiens_hsa003800.72285786
96Inositol phosphate metabolism_Homo sapiens_hsa005620.72117285
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71691924
98Primary immunodeficiency_Homo sapiens_hsa053400.71341718
99Choline metabolism in cancer_Homo sapiens_hsa052310.71288457
100Gap junction_Homo sapiens_hsa045400.71256222
101Cardiac muscle contraction_Homo sapiens_hsa042600.71087294
102Dilated cardiomyopathy_Homo sapiens_hsa054140.70984508
103ABC transporters_Homo sapiens_hsa020100.69790851
104Butanoate metabolism_Homo sapiens_hsa006500.69593376
105Leishmaniasis_Homo sapiens_hsa051400.68668434
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68432607
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68279082
108Fatty acid degradation_Homo sapiens_hsa000710.67552768
109Serotonergic synapse_Homo sapiens_hsa047260.67244295
110ErbB signaling pathway_Homo sapiens_hsa040120.67064013
111Chemokine signaling pathway_Homo sapiens_hsa040620.66958598
112Non-small cell lung cancer_Homo sapiens_hsa052230.66132979
113Lysosome_Homo sapiens_hsa041420.65468644
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.65355620
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.64737955
116Fatty acid metabolism_Homo sapiens_hsa012120.64367121
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63914170
118Insulin signaling pathway_Homo sapiens_hsa049100.63547361
119Ras signaling pathway_Homo sapiens_hsa040140.62543491
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.62453699
121FoxO signaling pathway_Homo sapiens_hsa040680.62303723
122Other glycan degradation_Homo sapiens_hsa005110.61777431
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61359194
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59505963
125TNF signaling pathway_Homo sapiens_hsa046680.58342383
126Axon guidance_Homo sapiens_hsa043600.57092874
127Thyroid hormone synthesis_Homo sapiens_hsa049180.55345239
128Tuberculosis_Homo sapiens_hsa051520.55294798
129Prion diseases_Homo sapiens_hsa050200.55226409
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54811058
131Glioma_Homo sapiens_hsa052140.54634117
132Complement and coagulation cascades_Homo sapiens_hsa046100.54170202
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53870851
134Estrogen signaling pathway_Homo sapiens_hsa049150.52340370
135Glycerolipid metabolism_Homo sapiens_hsa005610.50229343
136Fatty acid biosynthesis_Homo sapiens_hsa000610.49042361
137Fructose and mannose metabolism_Homo sapiens_hsa000510.48991391
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48502398
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.48188917
140MAPK signaling pathway_Homo sapiens_hsa040100.46549368
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44603220
142Insulin resistance_Homo sapiens_hsa049310.43536778
143Arginine biosynthesis_Homo sapiens_hsa002200.42685778
144Collecting duct acid secretion_Homo sapiens_hsa049660.42614066
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40610531
146Vibrio cholerae infection_Homo sapiens_hsa051100.40504384
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.39535145
148Non-homologous end-joining_Homo sapiens_hsa034500.38417809
149Pancreatic secretion_Homo sapiens_hsa049720.36571128
150Alcoholism_Homo sapiens_hsa050340.35880753

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