TRAPPC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.68183836
2protein deneddylation (GO:0000338)5.32583494
3protein neddylation (GO:0045116)3.99109186
4protein complex biogenesis (GO:0070271)3.97816184
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84617405
6mitochondrial respiratory chain complex I assembly (GO:0032981)3.84617405
7NADH dehydrogenase complex assembly (GO:0010257)3.84617405
8protein-cofactor linkage (GO:0018065)3.83681612
97-methylguanosine mRNA capping (GO:0006370)3.72256213
10mitochondrial respiratory chain complex assembly (GO:0033108)3.67053883
11RNA capping (GO:0036260)3.66757345
127-methylguanosine RNA capping (GO:0009452)3.66757345
13L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.65484050
14proteasome assembly (GO:0043248)3.65179259
15protein prenylation (GO:0018342)3.64871274
16prenylation (GO:0097354)3.64871274
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56850210
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56850210
19positive regulation of mitochondrial fission (GO:0090141)3.54826203
20presynaptic membrane assembly (GO:0097105)3.52378458
21regulation of mitotic spindle checkpoint (GO:1903504)3.51614248
22regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51614248
23regulation of mitochondrial translation (GO:0070129)3.49650880
24negative regulation of dendrite morphogenesis (GO:0050774)3.49478215
25response to pheromone (GO:0019236)3.48234378
26purine nucleobase biosynthetic process (GO:0009113)3.40908765
27inositol phosphate catabolic process (GO:0071545)3.39499552
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.38769318
29termination of RNA polymerase III transcription (GO:0006386)3.38769318
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.38294794
31respiratory chain complex IV assembly (GO:0008535)3.36320285
32water-soluble vitamin biosynthetic process (GO:0042364)3.33355300
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33184110
34synapsis (GO:0007129)3.30604552
35chaperone-mediated protein transport (GO:0072321)3.28148280
36intraciliary transport (GO:0042073)3.27064015
37resolution of meiotic recombination intermediates (GO:0000712)3.22956116
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22813740
39DNA double-strand break processing (GO:0000729)3.22294212
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20922892
41cytochrome complex assembly (GO:0017004)3.20262994
42chromatin remodeling at centromere (GO:0031055)3.15490763
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14485327
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12149243
45protein K6-linked ubiquitination (GO:0085020)3.11296578
46replication fork processing (GO:0031297)3.11282217
47platelet dense granule organization (GO:0060155)3.09449253
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06839370
49negative regulation of ligase activity (GO:0051352)3.06839370
502-deoxyribonucleotide biosynthetic process (GO:0009265)3.05126649
51deoxyribose phosphate biosynthetic process (GO:0046385)3.05126649
52somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05066607
53somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05066607
54isotype switching (GO:0045190)3.05066607
55regulation of DNA endoreduplication (GO:0032875)3.04777678
56histone H2A acetylation (GO:0043968)3.03801637
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02503339
58signal peptide processing (GO:0006465)3.01885837
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99906484
60nucleobase biosynthetic process (GO:0046112)2.99861235
61ER overload response (GO:0006983)2.99032491
62anterograde synaptic vesicle transport (GO:0048490)2.98809730
63DNA damage response, detection of DNA damage (GO:0042769)2.97518423
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97270901
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96176163
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96176163
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96176163
68maturation of 5.8S rRNA (GO:0000460)2.94872021
69presynaptic membrane organization (GO:0097090)2.94815723
70transferrin transport (GO:0033572)2.94465109
71transcription elongation from RNA polymerase I promoter (GO:0006362)2.94213878
72regulation of cellular amino acid metabolic process (GO:0006521)2.94184585
73regulation of hexokinase activity (GO:1903299)2.93839733
74regulation of glucokinase activity (GO:0033131)2.93839733
75attachment of spindle microtubules to kinetochore (GO:0008608)2.93250863
76viral mRNA export from host cell nucleus (GO:0046784)2.93101731
77inositol phosphate dephosphorylation (GO:0046855)2.92004258
78phosphorylated carbohydrate dephosphorylation (GO:0046838)2.92004258
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91888696
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91888696
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90919451
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88476517
83polyketide metabolic process (GO:0030638)2.88450657
84doxorubicin metabolic process (GO:0044598)2.88450657
85daunorubicin metabolic process (GO:0044597)2.88450657
86deoxyribonucleotide biosynthetic process (GO:0009263)2.88222007
87dopamine transport (GO:0015872)2.87944177
88positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87722823
89neural tube formation (GO:0001841)2.86710384
90DNA ligation (GO:0006266)2.86211167
91peptidyl-histidine modification (GO:0018202)2.86183080
92establishment of protein localization to mitochondrial membrane (GO:0090151)2.83549404
93branched-chain amino acid catabolic process (GO:0009083)2.83510295
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82763239
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.82763239
96guanosine-containing compound biosynthetic process (GO:1901070)2.82404469
97signal transduction involved in cell cycle checkpoint (GO:0072395)2.81258911
98negative regulation of DNA recombination (GO:0045910)2.80439969
99transcription-coupled nucleotide-excision repair (GO:0006283)2.79667215
100transcription from RNA polymerase I promoter (GO:0006360)2.77691298
101lactate metabolic process (GO:0006089)2.76330336
102startle response (GO:0001964)2.75464215
103termination of RNA polymerase I transcription (GO:0006363)2.75460673
104ferric iron transport (GO:0015682)2.75003745
105trivalent inorganic cation transport (GO:0072512)2.75003745
106histone mRNA metabolic process (GO:0008334)2.73817742
107L-methionine biosynthetic process (GO:0071265)2.73371198
108amino acid salvage (GO:0043102)2.73371198
109L-methionine salvage (GO:0071267)2.73371198
110positive regulation of ligase activity (GO:0051351)2.72416483
111righting reflex (GO:0060013)2.72307046
112histone exchange (GO:0043486)2.72119213
113rRNA modification (GO:0000154)2.71188820
114ribonucleoprotein complex disassembly (GO:0032988)2.70799039
115regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.70042090
116GMP metabolic process (GO:0046037)2.68683209
117protein targeting to mitochondrion (GO:0006626)2.68015088
118establishment of protein localization to mitochondrion (GO:0072655)2.67715546
119regulation of acyl-CoA biosynthetic process (GO:0050812)2.67521209
120cellular ketone body metabolic process (GO:0046950)2.65214527
121transcription initiation from RNA polymerase I promoter (GO:0006361)2.64695398
122polyol catabolic process (GO:0046174)2.64114319
123ATP hydrolysis coupled proton transport (GO:0015991)2.63846790
124energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.63846790
125protein K11-linked ubiquitination (GO:0070979)2.63326741
126detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62262472
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61674163
128energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60629081
129ATP synthesis coupled proton transport (GO:0015986)2.60629081
130non-recombinational repair (GO:0000726)2.59483920
131double-strand break repair via nonhomologous end joining (GO:0006303)2.59483920
132rRNA methylation (GO:0031167)2.58986953
133regulation of meiosis I (GO:0060631)2.57203838
134neuron cell-cell adhesion (GO:0007158)2.57135535
135protein localization to cilium (GO:0061512)2.56785535
136deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.56222825
137ketone body metabolic process (GO:1902224)2.55861932
138DNA integration (GO:0015074)2.55743718
139preassembly of GPI anchor in ER membrane (GO:0016254)2.55390445
140organelle disassembly (GO:1903008)2.55168796
141DNA catabolic process, exonucleolytic (GO:0000738)2.55008021
142protein K11-linked deubiquitination (GO:0035871)2.53635207
143neuronal action potential propagation (GO:0019227)2.53559658
144pseudouridine synthesis (GO:0001522)2.53151954
145CENP-A containing nucleosome assembly (GO:0034080)2.53079947
146regulation of ubiquitin-protein transferase activity (GO:0051438)2.53005232
147serotonin receptor signaling pathway (GO:0007210)2.52338925
148oxidative phosphorylation (GO:0006119)2.51912643
149DNA deamination (GO:0045006)2.51826419
150adenosine metabolic process (GO:0046085)2.51163230
151somatic hypermutation of immunoglobulin genes (GO:0016446)2.49931770
152somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49931770
153nonmotile primary cilium assembly (GO:0035058)2.48240340
154regulation of coenzyme metabolic process (GO:0051196)2.44213406
155regulation of cofactor metabolic process (GO:0051193)2.44213406
156regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43477437
157microtubule anchoring (GO:0034453)2.41050063
158recombinational repair (GO:0000725)2.39539533
159postreplication repair (GO:0006301)2.39444217
160single strand break repair (GO:0000012)2.38783730
161DNA replication-independent nucleosome assembly (GO:0006336)2.38373685
162DNA replication-independent nucleosome organization (GO:0034724)2.38373685
163C-terminal protein lipidation (GO:0006501)2.37117003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47467798
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.31775871
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15307533
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12420608
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.01004467
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74836032
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63181181
8GBX2_23144817_ChIP-Seq_PC3_Human2.62135835
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59285485
10ZNF274_21170338_ChIP-Seq_K562_Hela2.56903998
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44200769
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39404760
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.38757419
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37296734
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.30190686
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27662810
17E2F7_22180533_ChIP-Seq_HELA_Human2.26760000
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15705090
19TAF15_26573619_Chip-Seq_HEK293_Human2.12012382
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.09195528
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08604806
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08257728
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06496124
24ELK1_19687146_ChIP-ChIP_HELA_Human2.02222561
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.99320646
26FUS_26573619_Chip-Seq_HEK293_Human1.98057692
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95465336
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95337177
29VDR_23849224_ChIP-Seq_CD4+_Human1.89370155
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87479593
31VDR_22108803_ChIP-Seq_LS180_Human1.82271099
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79835733
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75127161
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74095849
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73249746
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71537058
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67770723
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67070480
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65726433
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.65505047
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64004672
42FOXP3_21729870_ChIP-Seq_TREG_Human1.63444299
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.61270579
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61203411
45EWS_26573619_Chip-Seq_HEK293_Human1.61082717
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.61027152
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59374385
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55949445
49DCP1A_22483619_ChIP-Seq_HELA_Human1.54725238
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53677852
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53135655
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49649565
53P300_19829295_ChIP-Seq_ESCs_Human1.45534821
54IRF1_19129219_ChIP-ChIP_H3396_Human1.45094568
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42423420
56CBP_20019798_ChIP-Seq_JUKART_Human1.40573200
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40573200
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40227562
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37798837
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35495523
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33802703
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33285229
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33014782
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32418865
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30871223
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30515876
67GABP_19822575_ChIP-Seq_HepG2_Human1.30261084
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29432190
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29283906
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28771859
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.27487865
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.27467433
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26935530
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26406020
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24803570
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24346113
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23986781
78RNF2_27304074_Chip-Seq_NSC_Mouse1.23785079
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.23655522
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.22199110
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21993863
82STAT3_23295773_ChIP-Seq_U87_Human1.21278868
83AR_25329375_ChIP-Seq_VCAP_Human1.20632695
84TP53_22573176_ChIP-Seq_HFKS_Human1.16850514
85NANOG_19829295_ChIP-Seq_ESCs_Human1.16698593
86SOX2_19829295_ChIP-Seq_ESCs_Human1.16698593
87TCF4_22108803_ChIP-Seq_LS180_Human1.15129746
88TTF2_22483619_ChIP-Seq_HELA_Human1.14791274
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14567757
90BCAT_22108803_ChIP-Seq_LS180_Human1.13919205
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13423713
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12680767
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12414286
94REST_19997604_ChIP-ChIP_NEURONS_Mouse1.12030596
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11954770
96ER_23166858_ChIP-Seq_MCF-7_Human1.11859185
97TCF4_23295773_ChIP-Seq_U87_Human1.11126787
98MYC_18940864_ChIP-ChIP_HL60_Human1.10259629
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09535612
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08697724
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08650940
102IGF1R_20145208_ChIP-Seq_DFB_Human1.08546996
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.08266913
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08115072
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07351399
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.06819988
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.05768098
108SALL1_21062744_ChIP-ChIP_HESCs_Human1.04868151
109JUN_21703547_ChIP-Seq_K562_Human1.04857739
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04571427
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04504284
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.03682371
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03476377
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03382079
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03328763
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03065251
117P53_22387025_ChIP-Seq_ESCs_Mouse1.03059193
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02957460
119ELK1_22589737_ChIP-Seq_MCF10A_Human1.02881686
120HTT_18923047_ChIP-ChIP_STHdh_Human1.02192625
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01902023
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01039861
123CDX2_22108803_ChIP-Seq_LS180_Human1.00729018
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00201845
125CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99516166
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99445708
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.99178833
128E2F1_18555785_Chip-Seq_ESCs_Mouse0.98987178
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98889757
130P300_18555785_Chip-Seq_ESCs_Mouse0.98814217
131SMAD4_21799915_ChIP-Seq_A2780_Human0.98048798
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93987965
133XRN2_22483619_ChIP-Seq_HELA_Human0.93521291
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.93475414
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92858491
136NMYC_18555785_Chip-Seq_ESCs_Mouse0.91894352
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.91581348
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.91226626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.35240011
2MP0003880_abnormal_central_pattern3.29010895
3MP0000569_abnormal_digit_pigmentation2.96431955
4MP0002102_abnormal_ear_morphology2.74768019
5MP0001188_hyperpigmentation2.69700943
6MP0006292_abnormal_olfactory_placode2.54930397
7MP0003195_calcinosis2.38349167
8MP0010386_abnormal_urinary_bladder2.34731559
9MP0001529_abnormal_vocalization2.30355984
10MP0006276_abnormal_autonomic_nervous2.28673578
11MP0003123_paternal_imprinting2.25036888
12MP0002735_abnormal_chemical_nociception2.24315727
13MP0002876_abnormal_thyroid_physiology2.19303705
14MP0008877_abnormal_DNA_methylation2.16687472
15MP0001984_abnormal_olfaction2.16282337
16MP0009697_abnormal_copulation2.09229411
17MP0005171_absent_coat_pigmentation2.08165857
18MP0005646_abnormal_pituitary_gland2.04494752
19MP0001968_abnormal_touch/_nociception2.00632582
20MP0008058_abnormal_DNA_repair1.98606347
21MP0002734_abnormal_mechanical_nocicepti1.98535724
22MP0002736_abnormal_nociception_after1.96982791
23MP0003787_abnormal_imprinting1.95385331
24MP0006072_abnormal_retinal_apoptosis1.93366727
25MP0001905_abnormal_dopamine_level1.91768864
26MP0008057_abnormal_DNA_replication1.86956666
27MP0004270_analgesia1.83142316
28MP0004215_abnormal_myocardial_fiber1.82135399
29MP0010234_abnormal_vibrissa_follicle1.81523950
30MP0000372_irregular_coat_pigmentation1.81156408
31MP0002272_abnormal_nervous_system1.80479897
32MP0009745_abnormal_behavioral_response1.79596553
33MP0003693_abnormal_embryo_hatching1.77031893
34MP0002090_abnormal_vision1.75460231
35MP0003122_maternal_imprinting1.66605640
36MP0009046_muscle_twitch1.66557991
37MP0002160_abnormal_reproductive_system1.63992535
38MP0003121_genomic_imprinting1.63810773
39MP0003635_abnormal_synaptic_transmissio1.62610341
40MP0002163_abnormal_gland_morphology1.60817228
41MP0004142_abnormal_muscle_tone1.59870065
42MP0002572_abnormal_emotion/affect_behav1.58121378
43MP0002064_seizures1.57482431
44MP0004957_abnormal_blastocyst_morpholog1.56696474
45MP0005379_endocrine/exocrine_gland_phen1.55274423
46MP0002063_abnormal_learning/memory/cond1.53639008
47MP0005645_abnormal_hypothalamus_physiol1.53355920
48MP0005075_abnormal_melanosome_morpholog1.53235763
49MP0010094_abnormal_chromosome_stability1.49458644
50MP0005389_reproductive_system_phenotype1.45536157
51MP0002638_abnormal_pupillary_reflex1.43783674
52MP0001919_abnormal_reproductive_system1.41936277
53MP0008932_abnormal_embryonic_tissue1.37170482
54MP0003786_premature_aging1.37074886
55MP0002067_abnormal_sensory_capabilities1.35507657
56MP0000427_abnormal_hair_cycle1.34885675
57MP0008260_abnormal_autophagy1.32170075
58MP0001486_abnormal_startle_reflex1.28796638
59MP0000631_abnormal_neuroendocrine_gland1.28528738
60MP0002938_white_spotting1.26852546
61MP0002751_abnormal_autonomic_nervous1.26743989
62MP0004133_heterotaxia1.24386679
63MP0005551_abnormal_eye_electrophysiolog1.22719931
64MP0001542_abnormal_bone_strength1.22617837
65MP0002184_abnormal_innervation1.22045510
66MP0001970_abnormal_pain_threshold1.21661729
67MP0003950_abnormal_plasma_membrane1.21355669
68MP0002009_preneoplasia1.21171078
69MP0005253_abnormal_eye_physiology1.19944953
70MP0003137_abnormal_impulse_conducting1.18117586
71MP0005408_hypopigmentation1.18089781
72MP0000013_abnormal_adipose_tissue1.16675497
73MP0004147_increased_porphyrin_level1.16101328
74MP0004043_abnormal_pH_regulation1.16026841
75MP0003136_yellow_coat_color1.15406547
76MP0004885_abnormal_endolymph1.15344484
77MP0002733_abnormal_thermal_nociception1.14427162
78MP0003183_abnormal_peptide_metabolism1.12701442
79MP0008789_abnormal_olfactory_epithelium1.10761558
80MP0003718_maternal_effect1.10077768
81MP0006036_abnormal_mitochondrial_physio1.10020892
82MP0005386_behavior/neurological_phenoty1.09406390
83MP0004924_abnormal_behavior1.09406390
84MP0006035_abnormal_mitochondrial_morpho1.09099065
85MP0000778_abnormal_nervous_system1.08469534
86MP0003186_abnormal_redox_activity1.03957206
87MP0003077_abnormal_cell_cycle1.03411709
88MP0000681_abnormal_thyroid_gland1.03332890
89MP0003221_abnormal_cardiomyocyte_apopto1.02878350
90MP0002822_catalepsy1.02039987
91MP0005423_abnormal_somatic_nervous1.01276393
92MP0001501_abnormal_sleep_pattern1.01213553
93MP0005084_abnormal_gallbladder_morpholo1.00496750
94MP0005499_abnormal_olfactory_system1.00462965
95MP0005394_taste/olfaction_phenotype1.00462965
96MP0002095_abnormal_skin_pigmentation1.00087618
97MP0001929_abnormal_gametogenesis0.99113282
98MP0002557_abnormal_social/conspecific_i0.98583420
99MP0000647_abnormal_sebaceous_gland0.98438976
100MP0005174_abnormal_tail_pigmentation0.97845527
101MP0001963_abnormal_hearing_physiology0.97649033
102MP0003011_delayed_dark_adaptation0.97505336
103MP0000516_abnormal_urinary_system0.96562338
104MP0005367_renal/urinary_system_phenotyp0.96562338
105MP0001177_atelectasis0.94263116
106MP0002254_reproductive_system_inflammat0.93267907
107MP0005248_abnormal_Harderian_gland0.91801541
108MP0002234_abnormal_pharynx_morphology0.91164564
109MP0000015_abnormal_ear_pigmentation0.89634516
110MP0003111_abnormal_nucleus_morphology0.89390717
111MP0010678_abnormal_skin_adnexa0.89090151
112MP0002837_dystrophic_cardiac_calcinosis0.89000991
113MP0001764_abnormal_homeostasis0.87915843
114MP0004859_abnormal_synaptic_plasticity0.87870585
115MP0008995_early_reproductive_senescence0.87258819
116MP0001485_abnormal_pinna_reflex0.86662989
117MP0003567_abnormal_fetal_cardiomyocyte0.85162203
118MP0006054_spinal_hemorrhage0.84793148
119MP0003315_abnormal_perineum_morphology0.83854494
120MP0005187_abnormal_penis_morphology0.83506639
121MP0000026_abnormal_inner_ear0.81397067
122MP0003806_abnormal_nucleotide_metabolis0.79311615
123MP0002882_abnormal_neuron_morphology0.79234555
124MP0002210_abnormal_sex_determination0.78394934
125MP0003890_abnormal_embryonic-extraembry0.78368779
126MP0001440_abnormal_grooming_behavior0.78283833
127MP0003656_abnormal_erythrocyte_physiolo0.77860467
128MP0008007_abnormal_cellular_replicative0.77382626
129MP0000653_abnormal_sex_gland0.76967624
130MP0001186_pigmentation_phenotype0.76289851
131MP0002752_abnormal_somatic_nervous0.75406090
132MP0004782_abnormal_surfactant_physiolog0.74966034
133MP0010030_abnormal_orbit_morphology0.74692800

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.44158692
2Acute necrotizing encephalopathy (HP:0006965)4.39888333
3Abnormal mitochondria in muscle tissue (HP:0008316)4.02423896
4Progressive macrocephaly (HP:0004481)3.87751639
5Focal motor seizures (HP:0011153)3.85942712
6Mitochondrial inheritance (HP:0001427)3.83747900
7Increased CSF lactate (HP:0002490)3.60618523
8Medial flaring of the eyebrow (HP:0010747)3.57863331
9Acute encephalopathy (HP:0006846)3.42282841
10Atonic seizures (HP:0010819)3.38618194
11Pancreatic fibrosis (HP:0100732)3.36157924
12Abnormal hair whorl (HP:0010721)3.35307818
13Hepatocellular necrosis (HP:0001404)3.26570122
14Congenital primary aphakia (HP:0007707)3.26346965
15Gait imbalance (HP:0002141)3.24890520
16Nephrogenic diabetes insipidus (HP:0009806)3.23175186
17Abnormality of glycolysis (HP:0004366)3.12901461
18Increased serum pyruvate (HP:0003542)3.12901461
19Renal cortical cysts (HP:0000803)3.06271631
20True hermaphroditism (HP:0010459)2.93860642
21Febrile seizures (HP:0002373)2.79983364
22Abnormality of the labia minora (HP:0012880)2.79708259
23Poor suck (HP:0002033)2.77398262
24Volvulus (HP:0002580)2.71734290
25Hepatic necrosis (HP:0002605)2.67053671
26Genital tract atresia (HP:0001827)2.63476315
27Microvesicular hepatic steatosis (HP:0001414)2.63242292
28Poor coordination (HP:0002370)2.62386165
29Type I transferrin isoform profile (HP:0003642)2.60680958
30Type 2 muscle fiber atrophy (HP:0003554)2.54801128
31Increased serum lactate (HP:0002151)2.51960029
32Abnormality of the renal cortex (HP:0011035)2.51299796
33Hypoglycemic coma (HP:0001325)2.49123332
34Increased hepatocellular lipid droplets (HP:0006565)2.49070184
35Colon cancer (HP:0003003)2.47995695
36Methylmalonic acidemia (HP:0002912)2.47030253
37Epileptic encephalopathy (HP:0200134)2.46017708
38Birth length less than 3rd percentile (HP:0003561)2.44242359
39Vaginal atresia (HP:0000148)2.43095517
40Abnormality of alanine metabolism (HP:0010916)2.40448493
41Hyperalaninemia (HP:0003348)2.40448493
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40448493
43Neuroendocrine neoplasm (HP:0100634)2.39155675
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38968494
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.38968494
46Large for gestational age (HP:0001520)2.36954231
47Pancreatic cysts (HP:0001737)2.36660366
48Nephronophthisis (HP:0000090)2.34405859
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.32237111
50Metaphyseal dysplasia (HP:0100255)2.31992364
51Lactic acidosis (HP:0003128)2.29819560
52Exercise intolerance (HP:0003546)2.25030123
53Hyperventilation (HP:0002883)2.24743117
54Cerebral hypomyelination (HP:0006808)2.23209826
55Optic disc pallor (HP:0000543)2.20332795
56Pancreatic islet-cell hyperplasia (HP:0004510)2.19674537
57Absence seizures (HP:0002121)2.16720096
58Respiratory failure (HP:0002878)2.13085106
59Renal Fanconi syndrome (HP:0001994)2.12416271
60Median cleft lip (HP:0000161)2.10316185
61Hyperinsulinemic hypoglycemia (HP:0000825)2.10014451
62Lipid accumulation in hepatocytes (HP:0006561)2.09012480
633-Methylglutaconic aciduria (HP:0003535)2.08891245
64Short tibia (HP:0005736)2.08464843
65Tongue fasciculations (HP:0001308)2.07574435
66Muscle fiber atrophy (HP:0100295)2.07216976
67Pheochromocytoma (HP:0002666)2.07049627
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05013748
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99897899
70Abnormality of methionine metabolism (HP:0010901)1.98055079
71Unsteady gait (HP:0002317)1.96610624
72Oligomenorrhea (HP:0000876)1.95777117
73Abnormality of chromosome stability (HP:0003220)1.95165302
74Abnormal glycosylation (HP:0012345)1.95035452
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95035452
76Abnormal protein N-linked glycosylation (HP:0012347)1.95035452
77Abnormal protein glycosylation (HP:0012346)1.95035452
78Absent speech (HP:0001344)1.94983996
79Agnosia (HP:0010524)1.93602409
80Abnormality of the renal medulla (HP:0100957)1.93273479
81Preaxial hand polydactyly (HP:0001177)1.93118464
82Dialeptic seizures (HP:0011146)1.92825575
83Cerebral edema (HP:0002181)1.92638187
84Hypoplasia of the fovea (HP:0007750)1.92615721
85Aplasia/Hypoplasia of the fovea (HP:0008060)1.92615721
86Degeneration of anterior horn cells (HP:0002398)1.91544067
87Abnormality of the anterior horn cell (HP:0006802)1.91544067
88Chronic hepatic failure (HP:0100626)1.90817592
89Methylmalonic aciduria (HP:0012120)1.89617910
90Congenital stationary night blindness (HP:0007642)1.88830784
91Hypomagnesemia (HP:0002917)1.88531549
92Aplasia/Hypoplasia of the lens (HP:0008063)1.88439067
93Broad foot (HP:0001769)1.88273826
94Furrowed tongue (HP:0000221)1.87633367
95Abnormal biliary tract physiology (HP:0012439)1.87594348
96Bile duct proliferation (HP:0001408)1.87594348
97Molar tooth sign on MRI (HP:0002419)1.87388059
98Abnormality of midbrain morphology (HP:0002418)1.87388059
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.87290088
100Ketoacidosis (HP:0001993)1.86710072
101Abnormal lung lobation (HP:0002101)1.86032564
102Abnormality of the pons (HP:0007361)1.85333908
103Abnormality of macular pigmentation (HP:0008002)1.85224859
104Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85168372
105Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85168372
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.85058518
107Prostate neoplasm (HP:0100787)1.84764073
108Postaxial hand polydactyly (HP:0001162)1.84648056
109Abolished electroretinogram (ERG) (HP:0000550)1.83972332
110Leukodystrophy (HP:0002415)1.83591261
111Thyroiditis (HP:0100646)1.83349099
112Limb dystonia (HP:0002451)1.82481029
113Muscular hypotonia of the trunk (HP:0008936)1.79323021
114Amyotrophic lateral sclerosis (HP:0007354)1.79166047
115Embryonal renal neoplasm (HP:0011794)1.78604978
116Abnormality of the corticospinal tract (HP:0002492)1.78271617
117Dyskinesia (HP:0100660)1.77676314
118Hypoglycemic seizures (HP:0002173)1.77190092
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76087764
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.75544786
121Male pseudohermaphroditism (HP:0000037)1.75100650
122Oligodactyly (hands) (HP:0001180)1.75018879
123Polyphagia (HP:0002591)1.72145884
124Progressive inability to walk (HP:0002505)1.71548535
125Astrocytoma (HP:0009592)1.71291255
126Abnormality of the astrocytes (HP:0100707)1.71291255
127Postnatal microcephaly (HP:0005484)1.71070633
128Abnormality of vitamin B metabolism (HP:0004340)1.70353447
129Fetal akinesia sequence (HP:0001989)1.69075637
130Narrow forehead (HP:0000341)1.68863246
131Dysautonomia (HP:0002459)1.68675669
132Aganglionic megacolon (HP:0002251)1.68553665
133Diminished movement (HP:0002374)1.67624701
134Optic nerve hypoplasia (HP:0000609)1.67401866
135Glioma (HP:0009733)1.67151275
136Bifid tongue (HP:0010297)1.67136485
137Glycosuria (HP:0003076)1.66894892
138Abnormality of urine glucose concentration (HP:0011016)1.66894892
139Abnormality of dental color (HP:0011073)1.66892418
140Generalized aminoaciduria (HP:0002909)1.66586867
141Abnormality of the ileum (HP:0001549)1.66126987
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65745189
143Respiratory difficulties (HP:0002880)1.65146718
144Nephroblastoma (Wilms tumor) (HP:0002667)1.64832499
145Abnormality of renal resorption (HP:0011038)1.64700215
146Aplastic anemia (HP:0001915)1.63669024
147Intestinal atresia (HP:0011100)1.63010963
148Neoplasm of the adrenal gland (HP:0100631)1.62285848
149Facial cleft (HP:0002006)1.61773541
150Specific learning disability (HP:0001328)1.61481014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.30478865
2MAP3K123.05853728
3STK162.92337889
4AKT32.85227366
5MST42.82161910
6TRIM282.81989837
7MAP4K22.58780773
8BUB12.49060225
9PRPF4B2.22510573
10TSSK62.14918393
11EIF2AK12.13025129
12EIF2AK32.11998679
13SIK32.07251514
14NUAK11.98224082
15ZAK1.95939566
16BCR1.95435092
17MAP2K71.94011390
18SRPK11.91076040
19BRSK21.88236809
20VRK11.82043702
21PLK31.81251832
22PLK21.69845510
23NME11.66815459
24BRAF1.58997420
25NTRK31.55420980
26FRK1.53204012
27MKNK21.53051182
28CCNB11.48845173
29YES11.43021642
30MKNK11.39647235
31STK391.39232835
32ARAF1.38711060
33BMPR21.33347877
34CDK191.32895344
35ERBB31.31653932
36WEE11.29380140
37ADRBK21.28034391
38CSNK1G11.27478024
39CDK81.25686841
40PAK31.24060996
41MAPK131.22966388
42TNIK1.22682925
43MAP3K41.22223442
44BMPR1B1.19872624
45BRSK11.19478698
46CSNK1G21.18375207
47NEK61.16130927
48MINK11.07368668
49MARK11.06860520
50CSNK1A1L1.03724178
51PNCK1.02811895
52SGK20.97282388
53STK38L0.95246630
54DAPK10.93948733
55MYLK0.92043294
56TAOK30.90183386
57OXSR10.89159391
58PLK40.86395633
59WNK40.85816549
60SGK2230.83164525
61SGK4940.83164525
62LIMK10.82734166
63PLK10.81612143
64AURKA0.80091437
65GRK10.79992971
66STK30.79563623
67FGFR20.79319070
68CDC70.75808979
69CAMKK20.75779178
70PRKCG0.75732150
71IRAK30.75534270
72PRKCE0.74662311
73PINK10.72901177
74RPS6KB10.72149115
75PBK0.71067288
76ACVR1B0.68733475
77PHKG10.65661979
78PHKG20.65661979
79PRKCI0.65485590
80PDK20.63868639
81TTK0.63559934
82UHMK10.62948209
83GRK70.62813445
84INSRR0.62410547
85TLK10.59475883
86DYRK1A0.58799502
87DAPK20.58347741
88CAMK2B0.58054431
89CDK180.57906426
90PASK0.57508282
91ERBB40.56041487
92ATM0.55213687
93NEK10.54275422
94GRK50.53270280
95TNK20.52150039
96PDK30.51370031
97PDK40.51370031
98DYRK20.49889878
99CDK140.49782210
100EIF2AK20.49170099
101FER0.49052072
102WNK30.48931711
103OBSCN0.48824996
104ATR0.48518458
105KSR10.46118251
106TGFBR10.44662075
107FGFR10.43878228
108CAMK2A0.43563535
109TEC0.43452870
110CSNK2A10.43447675
111CAMK2D0.43405627
112CDK30.43218487
113MAP2K40.42889634
114CDK150.42767611
115MAP3K20.42715160
116EPHA40.41915337
117PIM20.41038051
118CSNK1G30.40795331
119MAPKAPK50.40224141
120CDK11A0.39643846
121BCKDK0.38176688
122MUSK0.37973488
123IRAK40.37713840
124CHEK20.37319931
125EPHA20.36632065
126CAMK2G0.35255524
127CSNK2A20.35049627
128DYRK30.31957959
129RAF10.29295160
130PRKACA0.29133064
131ADRBK10.27932938
132PRKACB0.27848044
133CSNK1A10.27277093
134AURKB0.27193513

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.79608255
2Protein export_Homo sapiens_hsa030603.36673711
3Oxidative phosphorylation_Homo sapiens_hsa001903.20925007
4RNA polymerase_Homo sapiens_hsa030203.12228489
5Collecting duct acid secretion_Homo sapiens_hsa049662.68036229
6Propanoate metabolism_Homo sapiens_hsa006402.56187173
7Mismatch repair_Homo sapiens_hsa034302.51732440
8Parkinsons disease_Homo sapiens_hsa050122.50799779
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41637470
10Synaptic vesicle cycle_Homo sapiens_hsa047212.24360778
11Vibrio cholerae infection_Homo sapiens_hsa051102.17979022
12DNA replication_Homo sapiens_hsa030302.14100460
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12539055
14Nucleotide excision repair_Homo sapiens_hsa034202.05173328
15Nicotine addiction_Homo sapiens_hsa050332.04144014
16Butanoate metabolism_Homo sapiens_hsa006501.99623000
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91456002
18Huntingtons disease_Homo sapiens_hsa050161.89960182
19Basal transcription factors_Homo sapiens_hsa030221.80710479
20Homologous recombination_Homo sapiens_hsa034401.75519288
21Base excision repair_Homo sapiens_hsa034101.74673265
22Pyrimidine metabolism_Homo sapiens_hsa002401.72908693
23Alzheimers disease_Homo sapiens_hsa050101.71680561
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65011210
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62750821
26Spliceosome_Homo sapiens_hsa030401.59532193
27RNA degradation_Homo sapiens_hsa030181.57792269
28RNA transport_Homo sapiens_hsa030131.56219037
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56121024
30Fanconi anemia pathway_Homo sapiens_hsa034601.52908938
31Purine metabolism_Homo sapiens_hsa002301.51277010
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47424086
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43347314
34Sulfur metabolism_Homo sapiens_hsa009201.36451254
35Phototransduction_Homo sapiens_hsa047441.31617563
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31552038
37Non-homologous end-joining_Homo sapiens_hsa034501.31291312
38Vitamin B6 metabolism_Homo sapiens_hsa007501.26519385
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.23463772
40GABAergic synapse_Homo sapiens_hsa047271.23128217
41Taste transduction_Homo sapiens_hsa047421.21311121
42Cell cycle_Homo sapiens_hsa041101.19623490
43Caffeine metabolism_Homo sapiens_hsa002321.19423070
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17892205
45Peroxisome_Homo sapiens_hsa041461.17275041
46Serotonergic synapse_Homo sapiens_hsa047261.17274539
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.16614272
48Morphine addiction_Homo sapiens_hsa050321.16186057
49Regulation of autophagy_Homo sapiens_hsa041401.15128644
50Tryptophan metabolism_Homo sapiens_hsa003801.14686019
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13649134
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10379210
53Nitrogen metabolism_Homo sapiens_hsa009101.05563179
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03123198
55Ribosome_Homo sapiens_hsa030101.02957446
56Olfactory transduction_Homo sapiens_hsa047401.01655408
57Oocyte meiosis_Homo sapiens_hsa041141.00137722
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99741448
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95486440
60Fatty acid metabolism_Homo sapiens_hsa012120.91520915
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91300445
62Phagosome_Homo sapiens_hsa041450.90943509
63Selenocompound metabolism_Homo sapiens_hsa004500.90591612
64Ether lipid metabolism_Homo sapiens_hsa005650.89486312
65Amphetamine addiction_Homo sapiens_hsa050310.88030077
66Rheumatoid arthritis_Homo sapiens_hsa053230.87269166
67Insulin secretion_Homo sapiens_hsa049110.84154091
68Dopaminergic synapse_Homo sapiens_hsa047280.83121877
69One carbon pool by folate_Homo sapiens_hsa006700.80543990
70Type I diabetes mellitus_Homo sapiens_hsa049400.79568507
71Alcoholism_Homo sapiens_hsa050340.79038255
72N-Glycan biosynthesis_Homo sapiens_hsa005100.78782133
73Circadian entrainment_Homo sapiens_hsa047130.77306504
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74926006
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73820733
76Fatty acid degradation_Homo sapiens_hsa000710.69433312
77beta-Alanine metabolism_Homo sapiens_hsa004100.67787117
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67492252
79Linoleic acid metabolism_Homo sapiens_hsa005910.67061987
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66660471
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66160550
82Fatty acid elongation_Homo sapiens_hsa000620.65254685
83mRNA surveillance pathway_Homo sapiens_hsa030150.65006613
84Long-term potentiation_Homo sapiens_hsa047200.63304174
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62716301
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61897528
87Glutamatergic synapse_Homo sapiens_hsa047240.61397900
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61155307
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60534064
90Metabolic pathways_Homo sapiens_hsa011000.59379131
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53170488
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51527663
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50669324
94Epstein-Barr virus infection_Homo sapiens_hsa051690.49792264
95Long-term depression_Homo sapiens_hsa047300.47850200
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47004775
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46990388
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45961343
99Arachidonic acid metabolism_Homo sapiens_hsa005900.44882094
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43278657
101Glutathione metabolism_Homo sapiens_hsa004800.42398893
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41833204
103Cholinergic synapse_Homo sapiens_hsa047250.41376019
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41163164
105Cocaine addiction_Homo sapiens_hsa050300.41068741
106Galactose metabolism_Homo sapiens_hsa000520.40193581
107Steroid biosynthesis_Homo sapiens_hsa001000.37696901
108Folate biosynthesis_Homo sapiens_hsa007900.37500758
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36803832
110Cardiac muscle contraction_Homo sapiens_hsa042600.36231199
111Pyruvate metabolism_Homo sapiens_hsa006200.36026404
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33906195
113Fructose and mannose metabolism_Homo sapiens_hsa000510.31792142
114Chemical carcinogenesis_Homo sapiens_hsa052040.31663657
115p53 signaling pathway_Homo sapiens_hsa041150.30911265
116Sphingolipid metabolism_Homo sapiens_hsa006000.30564803
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30524741
118Carbon metabolism_Homo sapiens_hsa012000.29490784
119Calcium signaling pathway_Homo sapiens_hsa040200.28168072
120Circadian rhythm_Homo sapiens_hsa047100.28022084
121Retinol metabolism_Homo sapiens_hsa008300.27678983
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.26610867
123Gap junction_Homo sapiens_hsa045400.26343960
124Thyroid cancer_Homo sapiens_hsa052160.25696983
125Systemic lupus erythematosus_Homo sapiens_hsa053220.24591884
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23137055
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21840007
128Melanoma_Homo sapiens_hsa052180.21184488
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.17878135

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