TRAPPC13P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)6.71986443
2pyrimidine nucleobase catabolic process (GO:0006208)6.56418579
3nucleobase catabolic process (GO:0046113)5.24473108
4axonal fasciculation (GO:0007413)5.17070996
5postsynaptic membrane organization (GO:0001941)4.91929316
6negative regulation of axon guidance (GO:1902668)4.85428580
7nonmotile primary cilium assembly (GO:0035058)4.78953920
8behavioral response to nicotine (GO:0035095)4.65577368
9neuron recognition (GO:0008038)4.63795457
10axon extension (GO:0048675)4.63770607
11establishment of mitochondrion localization (GO:0051654)4.51813207
12limb bud formation (GO:0060174)4.44134652
13neuron projection extension involved in neuron projection guidance (GO:1902284)4.35327687
14axon extension involved in axon guidance (GO:0048846)4.35327687
15negative regulation of axonogenesis (GO:0050771)4.31450015
16protein localization to cilium (GO:0061512)4.15870164
17retinal ganglion cell axon guidance (GO:0031290)4.11146055
18somite development (GO:0061053)4.05809208
19intraciliary transport (GO:0042073)3.99073887
20neuron projection extension (GO:1990138)3.90975194
21forebrain neuron differentiation (GO:0021879)3.86664709
22mitochondrion transport along microtubule (GO:0047497)3.76891939
23establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.76891939
24cell migration in hindbrain (GO:0021535)3.76603201
25cerebellar Purkinje cell differentiation (GO:0021702)3.69521752
26respiratory system process (GO:0003016)3.69452191
27glycosphingolipid biosynthetic process (GO:0006688)3.66121274
28presynaptic membrane assembly (GO:0097105)3.65853617
29regulation of short-term neuronal synaptic plasticity (GO:0048172)3.65561246
30neuron fate specification (GO:0048665)3.59026576
31appendage development (GO:0048736)3.53108405
32limb development (GO:0060173)3.53108405
33negative regulation of telomere maintenance (GO:0032205)3.51095975
34synaptic vesicle maturation (GO:0016188)3.48422654
35cellular biogenic amine catabolic process (GO:0042402)3.46903700
36amine catabolic process (GO:0009310)3.46903700
37olfactory bulb development (GO:0021772)3.44786487
38positive regulation of gastrulation (GO:2000543)3.42863282
39negative chemotaxis (GO:0050919)3.36117888
40regulation of telomere maintenance (GO:0032204)3.32848139
41negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.27271142
42hindbrain development (GO:0030902)3.26845481
43protein localization to synapse (GO:0035418)3.22967087
44otic vesicle formation (GO:0030916)3.22594138
45regulation of axon guidance (GO:1902667)3.21988277
46regulation of collateral sprouting (GO:0048670)3.21919847
47cornea development in camera-type eye (GO:0061303)3.20464871
48auditory behavior (GO:0031223)3.17549831
49resolution of meiotic recombination intermediates (GO:0000712)3.15867836
50neuron cell-cell adhesion (GO:0007158)3.15702653
51presynaptic membrane organization (GO:0097090)3.14300881
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10977359
53glycine transport (GO:0015816)3.08421774
54thalamus development (GO:0021794)3.06107761
55transmission of nerve impulse (GO:0019226)3.05911864
56negative regulation of axon extension (GO:0030517)3.01896593
57cholesterol biosynthetic process (GO:0006695)3.00022791
58neuron maturation (GO:0042551)2.99323349
59smoothened signaling pathway (GO:0007224)2.99215874
60synapse assembly (GO:0007416)2.99014478
61cilium morphogenesis (GO:0060271)2.98688566
62regulation of cilium movement (GO:0003352)2.98621321
63head development (GO:0060322)2.96570803
64seminiferous tubule development (GO:0072520)2.95269302
65neuronal action potential propagation (GO:0019227)2.94192161
66protein polyglutamylation (GO:0018095)2.93301307
67anterograde synaptic vesicle transport (GO:0048490)2.93040754
68cell differentiation in hindbrain (GO:0021533)2.91917857
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88620266
70photoreceptor cell development (GO:0042461)2.86740825
71regulation of microtubule-based movement (GO:0060632)2.86450847
72isoprenoid biosynthetic process (GO:0008299)2.86428853
73cilium assembly (GO:0042384)2.86160656
74cilium organization (GO:0044782)2.85306349
75negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84999140
76positive regulation of synapse assembly (GO:0051965)2.82896018
77vocalization behavior (GO:0071625)2.82204555
78mechanosensory behavior (GO:0007638)2.81999550
79sequestering of actin monomers (GO:0042989)2.81132398
80positive regulation of oligodendrocyte differentiation (GO:0048714)2.80123369
81sympathetic nervous system development (GO:0048485)2.79827467
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78638899
83cytoskeleton-dependent intracellular transport (GO:0030705)2.78125980
84hippocampus development (GO:0021766)2.77869949
85neurotransmitter secretion (GO:0007269)2.77862850
86negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.76839148
87negative regulation of DNA-templated transcription, elongation (GO:0032785)2.75906364
88cardiovascular system development (GO:0072358)2.75430038
89epithelial cell differentiation involved in kidney development (GO:0035850)2.75387883
90neuron migration (GO:0001764)2.73994082
91heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.72835804
92synaptic vesicle endocytosis (GO:0048488)2.72593060
93negative regulation of axon extension involved in axon guidance (GO:0048843)2.71744109
94positive regulation of filopodium assembly (GO:0051491)2.70582977
95mating behavior (GO:0007617)2.70472300
96developmental cell growth (GO:0048588)2.68663259
97peptidyl-cysteine modification (GO:0018198)2.68625928
98synaptic vesicle exocytosis (GO:0016079)2.68087768
99neuronal ion channel clustering (GO:0045161)2.66036912
100dendrite development (GO:0016358)2.65685677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.34297685
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.73834468
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.09369966
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.96987920
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93565884
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.82456091
7GBX2_23144817_ChIP-Seq_PC3_Human2.82220912
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.76132202
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74168453
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.68029509
11IGF1R_20145208_ChIP-Seq_DFB_Human2.66554356
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.53505554
13ZNF274_21170338_ChIP-Seq_K562_Hela2.40645277
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38497131
15REST_21632747_ChIP-Seq_MESCs_Mouse2.36505920
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35003168
17VDR_22108803_ChIP-Seq_LS180_Human2.32665389
18RNF2_27304074_Chip-Seq_NSC_Mouse2.29202568
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24128400
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20211580
21TAF15_26573619_Chip-Seq_HEK293_Human2.12714986
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10164962
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.04530064
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02456924
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00893446
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.95179114
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92038965
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.92038965
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91685427
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91685427
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91131994
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91116636
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85957411
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84176611
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.82466899
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82188021
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79334003
38FUS_26573619_Chip-Seq_HEK293_Human1.71236004
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69635218
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67198662
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.64809299
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60273185
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53269199
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48615853
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45792511
46P300_19829295_ChIP-Seq_ESCs_Human1.45319212
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.45100029
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39561323
49FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39057483
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38377945
51SMAD4_21799915_ChIP-Seq_A2780_Human1.34055033
52DROSHA_22980978_ChIP-Seq_HELA_Human1.33161058
53EWS_26573619_Chip-Seq_HEK293_Human1.31478551
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29613287
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24727712
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23499361
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23033459
58AR_21572438_ChIP-Seq_LNCaP_Human1.21211574
59CBP_20019798_ChIP-Seq_JUKART_Human1.19775115
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19775115
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.18997109
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18803859
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16371308
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14723983
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13623500
66IRF1_19129219_ChIP-ChIP_H3396_Human1.13407539
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.13023065
68AR_25329375_ChIP-Seq_VCAP_Human1.12653509
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12057695
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11504026
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.10957738
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10025829
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09773102
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08321631
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.07564944
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06835218
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.05873055
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05510232
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03894734
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.03875115
81TCF4_23295773_ChIP-Seq_U87_Human1.02096171
82MYC_18940864_ChIP-ChIP_HL60_Human1.00973756
83BCAT_22108803_ChIP-Seq_LS180_Human1.00788683
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99804158
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95755549
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92563994
87TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92545571
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92222565
89TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92152464
90STAT3_18555785_ChIP-Seq_MESCs_Mouse0.92126336
91TP53_22573176_ChIP-Seq_HFKS_Human0.92087262
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.91707361
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90242394
94STAT3_23295773_ChIP-Seq_U87_Human0.89980129
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89369308
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.88895872
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.87122271
98AR_19668381_ChIP-Seq_PC3_Human0.87002406
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86205398
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82004815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system4.54850809
2MP0003122_maternal_imprinting3.92623330
3MP0003880_abnormal_central_pattern3.34552784
4MP0006276_abnormal_autonomic_nervous3.32083553
5MP0000569_abnormal_digit_pigmentation3.22805671
6MP0005423_abnormal_somatic_nervous2.71582592
7MP0003121_genomic_imprinting2.62231834
8MP0004142_abnormal_muscle_tone2.54239177
9MP0000778_abnormal_nervous_system2.45610511
10MP0001529_abnormal_vocalization2.42859951
11MP0002102_abnormal_ear_morphology2.40005562
12MP0002234_abnormal_pharynx_morphology2.27739967
13MP0003283_abnormal_digestive_organ2.17270605
14MP0003787_abnormal_imprinting2.17239292
15MP0005394_taste/olfaction_phenotype2.05522015
16MP0005499_abnormal_olfactory_system2.05522015
17MP0002184_abnormal_innervation2.01925138
18MP0001293_anophthalmia1.94155520
19MP0008789_abnormal_olfactory_epithelium1.93025896
20MP0002063_abnormal_learning/memory/cond1.90887030
21MP0000566_synostosis1.88039367
22MP0003635_abnormal_synaptic_transmissio1.87629369
23MP0001984_abnormal_olfaction1.87285898
24MP0004859_abnormal_synaptic_plasticity1.86851508
25MP0004270_analgesia1.86789840
26MP0002272_abnormal_nervous_system1.86473723
27MP0001188_hyperpigmentation1.84040731
28MP0002822_catalepsy1.76229720
29MP0008995_early_reproductive_senescence1.70064328
30MP0002572_abnormal_emotion/affect_behav1.69823147
31MP0004133_heterotaxia1.69390693
32MP0003890_abnormal_embryonic-extraembry1.64847808
33MP0002928_abnormal_bile_duct1.62254206
34MP0002557_abnormal_social/conspecific_i1.58264304
35MP0005187_abnormal_penis_morphology1.53582110
36MP0002938_white_spotting1.52680752
37MP0009046_muscle_twitch1.51921869
38MP0000955_abnormal_spinal_cord1.46777667
39MP0006292_abnormal_olfactory_placode1.46737288
40MP0002734_abnormal_mechanical_nocicepti1.45665728
41MP0002882_abnormal_neuron_morphology1.42708115
42MP0009745_abnormal_behavioral_response1.41790279
43MP0002653_abnormal_ependyma_morphology1.41652462
44MP0002064_seizures1.40113073
45MP0001440_abnormal_grooming_behavior1.37458126
46MP0000631_abnormal_neuroendocrine_gland1.35250499
47MP0002751_abnormal_autonomic_nervous1.29180849
48MP0001486_abnormal_startle_reflex1.27886227
49MP0009053_abnormal_anal_canal1.27801655
50MP0000013_abnormal_adipose_tissue1.25364520
51MP0000647_abnormal_sebaceous_gland1.24432479
52MP0005084_abnormal_gallbladder_morpholo1.23010173
53MP0002752_abnormal_somatic_nervous1.22147140
54MP0003938_abnormal_ear_development1.21995552
55MP0000049_abnormal_middle_ear1.20831193
56MP0003119_abnormal_digestive_system1.19129413
57MP0002733_abnormal_thermal_nociception1.18502498
58MP0001324_abnormal_eye_pigmentation1.17444548
59MP0003315_abnormal_perineum_morphology1.17341238
60MP0001970_abnormal_pain_threshold1.17138178
61MP0005551_abnormal_eye_electrophysiolog1.15780870
62MP0003861_abnormal_nervous_system1.15666022
63MP0000372_irregular_coat_pigmentation1.13959707
64MP0005248_abnormal_Harderian_gland1.13372453
65MP0002152_abnormal_brain_morphology1.12404280
66MP0002233_abnormal_nose_morphology1.11637290
67MP0004885_abnormal_endolymph1.11222656
68MP0004811_abnormal_neuron_physiology1.11120883
69MP0004924_abnormal_behavior1.10416186
70MP0005386_behavior/neurological_phenoty1.10416186
71MP0000026_abnormal_inner_ear1.08807020
72MP0001986_abnormal_taste_sensitivity0.99396373
73MP0002736_abnormal_nociception_after0.99164477
74MP0002638_abnormal_pupillary_reflex0.96349455
75MP0002735_abnormal_chemical_nociception0.96282545
76MP0002066_abnormal_motor_capabilities/c0.95852081
77MP0003942_abnormal_urinary_system0.95494132
78MP0003385_abnormal_body_wall0.95035105
79MP0000534_abnormal_ureter_morphology0.94409772
80MP0001485_abnormal_pinna_reflex0.93448967
81MP0002067_abnormal_sensory_capabilities0.92236878
82MP0001905_abnormal_dopamine_level0.91595271
83MP0003879_abnormal_hair_cell0.90796267
84MP0003937_abnormal_limbs/digits/tail_de0.90456893
85MP0001963_abnormal_hearing_physiology0.90423930
86MP0008058_abnormal_DNA_repair0.90197774
87MP0005171_absent_coat_pigmentation0.89798996
88MP0005253_abnormal_eye_physiology0.89566551
89MP0003755_abnormal_palate_morphology0.89014784
90MP0000383_abnormal_hair_follicle0.88681288
91MP0002282_abnormal_trachea_morphology0.87676256
92MP0005391_vision/eye_phenotype0.84935789
93MP0008877_abnormal_DNA_methylation0.82870838
94MP0005645_abnormal_hypothalamus_physiol0.82018877
95MP0001968_abnormal_touch/_nociception0.81036749
96MP0002163_abnormal_gland_morphology0.78130640
97MP0005195_abnormal_posterior_eye0.77293411
98MP0002069_abnormal_eating/drinking_beha0.75189966
99MP0002081_perinatal_lethality0.73551597
100MP0002295_abnormal_pulmonary_circulatio0.72824367

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)5.85318710
2Abnormality of the labia minora (HP:0012880)5.25917088
3Polyphagia (HP:0002591)5.16679855
4True hermaphroditism (HP:0010459)4.77650893
5Pancreatic fibrosis (HP:0100732)4.64176981
6Gait imbalance (HP:0002141)4.53760006
7Pancreatic cysts (HP:0001737)4.05369613
8Congenital primary aphakia (HP:0007707)3.98832559
9Hip dysplasia (HP:0001385)3.84082121
10Medial flaring of the eyebrow (HP:0010747)3.83459495
11Abnormality of midbrain morphology (HP:0002418)3.81568206
12Molar tooth sign on MRI (HP:0002419)3.81568206
13Abnormal hair whorl (HP:0010721)3.76894650
14Nephronophthisis (HP:0000090)3.76710410
15Focal motor seizures (HP:0011153)3.76190861
16Poor suck (HP:0002033)3.65992374
17Nephrogenic diabetes insipidus (HP:0009806)3.64997010
18Atonic seizures (HP:0010819)3.49894776
19Limb dystonia (HP:0002451)3.49719023
20Poor coordination (HP:0002370)3.47708510
21Cystic liver disease (HP:0006706)3.37682167
22Oligomenorrhea (HP:0000876)3.34926681
23Specific learning disability (HP:0001328)3.27323375
24Febrile seizures (HP:0002373)3.27131766
25Vaginal atresia (HP:0000148)3.11138275
26Aplasia/Hypoplasia of the tongue (HP:0010295)3.07839056
27Sclerocornea (HP:0000647)3.01714292
28Genital tract atresia (HP:0001827)3.00503685
29Abnormal eating behavior (HP:0100738)2.97811299
30Postaxial foot polydactyly (HP:0001830)2.89613474
31Labial hypoplasia (HP:0000066)2.87044703
32Myokymia (HP:0002411)2.86381107
33Focal seizures (HP:0007359)2.85455021
34Epileptic encephalopathy (HP:0200134)2.84130781
35Anencephaly (HP:0002323)2.81952855
36Abnormality of the renal medulla (HP:0100957)2.74921375
37Sleep apnea (HP:0010535)2.73339534
38Narrow nasal bridge (HP:0000446)2.72103147
39Hypoplastic female external genitalia (HP:0012815)2.68115817
40Preaxial hand polydactyly (HP:0001177)2.67899840
41Cortical dysplasia (HP:0002539)2.66838776
42Chronic hepatic failure (HP:0100626)2.59503990
43Dialeptic seizures (HP:0011146)2.58138093
44Anophthalmia (HP:0000528)2.55659421
45Oligodactyly (hands) (HP:0001180)2.52459319
46Attenuation of retinal blood vessels (HP:0007843)2.52139237
47Bony spicule pigmentary retinopathy (HP:0007737)2.49033327
48Tubulointerstitial nephritis (HP:0001970)2.46956054
49Intestinal atresia (HP:0011100)2.43672357
50Growth hormone deficiency (HP:0000824)2.42982157
51Drooling (HP:0002307)2.36483452
52Agitation (HP:0000713)2.36286166
53Absence seizures (HP:0002121)2.31450509
54Narrow forehead (HP:0000341)2.29303501
55Abnormality of the corticospinal tract (HP:0002492)2.16026354
56Excessive salivation (HP:0003781)2.15765466
57Congenital stationary night blindness (HP:0007642)2.15399624
58Abnormality of the labia (HP:0000058)2.15201546
59Status epilepticus (HP:0002133)2.14871503
60Pachygyria (HP:0001302)2.14203529
61Scrotal hypoplasia (HP:0000046)2.10555862
62Broad foot (HP:0001769)2.10322873
63Aplasia/Hypoplasia of the lens (HP:0008063)2.09078077
64Postaxial hand polydactyly (HP:0001162)2.08562051
65Decreased testicular size (HP:0008734)2.07688029
66Hypoventilation (HP:0002791)2.07516655
67Progressive cerebellar ataxia (HP:0002073)2.07464132
68Chorioretinal coloboma (HP:0000567)2.05318439
69Decreased muscle mass (HP:0003199)2.04708473
70Ependymoma (HP:0002888)2.04395067
71Congenital hepatic fibrosis (HP:0002612)2.00402528
72Male pseudohermaphroditism (HP:0000037)1.99962724
73Absent speech (HP:0001344)1.99841483
74Hypogonadotrophic hypogonadism (HP:0000044)1.99703549
75Short foot (HP:0001773)1.96122728
76Lissencephaly (HP:0001339)1.95846699
77Furrowed tongue (HP:0000221)1.95557406
78Thyroid-stimulating hormone excess (HP:0002925)1.95012100
79Tubulointerstitial abnormality (HP:0001969)1.94265823
80Spastic tetraplegia (HP:0002510)1.91718132
81Abolished electroretinogram (ERG) (HP:0000550)1.91319821
82Hepatoblastoma (HP:0002884)1.90913218
83Micropenis (HP:0000054)1.90640110
84Renal cortical cysts (HP:0000803)1.89927879
85Bilateral microphthalmos (HP:0007633)1.89477446
86Split foot (HP:0001839)1.86291305
87Occipital encephalocele (HP:0002085)1.86156222
88Morphological abnormality of the middle ear (HP:0008609)1.84720648
89Abnormal rod and cone electroretinograms (HP:0008323)1.83749227
90EEG with generalized epileptiform discharges (HP:0011198)1.82646954
91Amyotrophic lateral sclerosis (HP:0007354)1.82474940
92Epileptiform EEG discharges (HP:0011182)1.82345644
93Dandy-Walker malformation (HP:0001305)1.81071606
94Abnormal drinking behavior (HP:0030082)1.80863086
95Polydipsia (HP:0001959)1.80863086
96Urinary urgency (HP:0000012)1.80655648
97Optic disc pallor (HP:0000543)1.79519914
98Spastic gait (HP:0002064)1.77964077
99Retinitis pigmentosa (HP:0000510)1.77934676
100Generalized hypotonia (HP:0001290)1.77387155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.29851937
2CASK3.86082182
3EPHA33.59972210
4WNK33.33527186
5MAPK132.89742158
6DYRK22.71218131
7MAP3K42.53071003
8TNIK2.41121683
9PINK12.38829412
10MAP2K72.01833739
11CDK191.90443279
12NTRK31.85409970
13STK161.84034230
14NTRK21.80498109
15BCR1.79604466
16MINK11.70997567
17PRKD31.61013290
18MAP2K41.48428542
19DYRK31.46727121
20DYRK1B1.38837585
21BMPR1B1.37070180
22CSNK1G21.31297991
23PRKCG1.30206585
24INSRR1.29357368
25DYRK1A1.27940131
26CSNK1G31.24674721
27OXSR11.21330304
28PHKG11.21290280
29PHKG21.21290280
30EPHA41.19075028
31BRD41.18360400
32MAP4K21.14263842
33SIK21.11479574
34CAMK11.11212898
35STK391.08965655
36EPHB21.08270842
37PAK31.07233707
38CSNK1A1L1.00344719
39LMTK21.00036869
40CSNK1G10.98229852
41ERBB30.95237926
42UHMK10.90132148
43CAMK1G0.90129536
44PRKCZ0.89486807
45CAMK1D0.89273828
46CDK50.88351724
47SIK30.86442166
48PKN10.85644184
49PRKAA10.83166294
50NTRK10.82255884
51MKNK20.80270858
52MKNK10.77890183
53ERBB20.74749545
54WNK40.72006700
55CDK80.67359148
56PNCK0.63732247
57CAMK2A0.63705048
58CDK140.62622971
59CDK180.62504440
60RPS6KA20.62322943
61TRIM280.62070319
62BRSK10.61836212
63PRKCE0.60001372
64PLK20.59434294
65CDK150.58636396
66CDK11A0.57806063
67FRK0.56678175
68TYRO30.53986600
69TGFBR10.52292906
70MAP3K60.52039170
71NME10.51980899
72PRKCQ0.51578058
73GRK10.51341614
74MAP3K120.49469664
75MAP3K50.49000907
76SGK2230.48570716
77SGK4940.48570716
78CSNK1D0.46844627
79RPS6KA50.46671631
80CSNK1E0.45046705
81PRKACA0.44920985
82ADRBK10.44814333
83MARK20.44014704
84MAPK150.43974878
85KSR10.41055565
86PRKG10.39375476
87MAPKAPK50.37943710
88CSNK1A10.36379980
89ARAF0.34368219
90DMPK0.33691931
91MAPK80.32272536
92PIM20.32169696
93CAMK2B0.31819596
94GRK50.31400067
95ZAK0.30588504
96PRKDC0.29617348
97PRKACB0.29301692
98FGFR10.28288962
99PRKD10.28066826
100IRAK10.27529461

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.58490577
2Steroid biosynthesis_Homo sapiens_hsa001003.67246057
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.79241081
4GABAergic synapse_Homo sapiens_hsa047272.70282289
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.62411449
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.61075805
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53930721
8Synaptic vesicle cycle_Homo sapiens_hsa047212.53369255
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35766284
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25266567
11Protein export_Homo sapiens_hsa030602.23667210
12Morphine addiction_Homo sapiens_hsa050322.15561122
13Hedgehog signaling pathway_Homo sapiens_hsa043402.13177350
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10113263
15Axon guidance_Homo sapiens_hsa043602.08817957
16Parkinsons disease_Homo sapiens_hsa050122.00607939
17Oxidative phosphorylation_Homo sapiens_hsa001901.98152181
18Phototransduction_Homo sapiens_hsa047441.75630732
19Butanoate metabolism_Homo sapiens_hsa006501.72081717
20Cocaine addiction_Homo sapiens_hsa050301.71432868
21Cardiac muscle contraction_Homo sapiens_hsa042601.69808573
22Sulfur relay system_Homo sapiens_hsa041221.68318658
23Dopaminergic synapse_Homo sapiens_hsa047281.67957168
24Basal cell carcinoma_Homo sapiens_hsa052171.54221638
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48942994
26Fatty acid biosynthesis_Homo sapiens_hsa000611.45684761
27Regulation of autophagy_Homo sapiens_hsa041401.45031160
28Circadian entrainment_Homo sapiens_hsa047131.36221178
29Glutamatergic synapse_Homo sapiens_hsa047241.30932573
30Taste transduction_Homo sapiens_hsa047421.29987987
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28768041
32Amphetamine addiction_Homo sapiens_hsa050311.28284146
33Alzheimers disease_Homo sapiens_hsa050101.26003224
34Serotonergic synapse_Homo sapiens_hsa047261.24242570
35Fanconi anemia pathway_Homo sapiens_hsa034601.20668039
36Cholinergic synapse_Homo sapiens_hsa047251.19758990
37Huntingtons disease_Homo sapiens_hsa050161.15297222
38Collecting duct acid secretion_Homo sapiens_hsa049661.13964484
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09472084
40Dorso-ventral axis formation_Homo sapiens_hsa043201.00387136
41RNA polymerase_Homo sapiens_hsa030200.97787112
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97662610
43Basal transcription factors_Homo sapiens_hsa030220.92367821
44Propanoate metabolism_Homo sapiens_hsa006400.90081317
45Oxytocin signaling pathway_Homo sapiens_hsa049210.84506031
46Alcoholism_Homo sapiens_hsa050340.83898137
47Insulin secretion_Homo sapiens_hsa049110.81740444
48Olfactory transduction_Homo sapiens_hsa047400.81458232
49Long-term depression_Homo sapiens_hsa047300.74834981
50Wnt signaling pathway_Homo sapiens_hsa043100.71894259
51Caffeine metabolism_Homo sapiens_hsa002320.71339934
52Melanogenesis_Homo sapiens_hsa049160.70328246
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69116651
54Gap junction_Homo sapiens_hsa045400.68553622
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67316993
56Hippo signaling pathway_Homo sapiens_hsa043900.66351067
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65307748
58Oocyte meiosis_Homo sapiens_hsa041140.64129403
59Linoleic acid metabolism_Homo sapiens_hsa005910.64108483
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62765226
61Arginine and proline metabolism_Homo sapiens_hsa003300.59740603
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58922143
63Vitamin digestion and absorption_Homo sapiens_hsa049770.57340901
64AMPK signaling pathway_Homo sapiens_hsa041520.56571526
65beta-Alanine metabolism_Homo sapiens_hsa004100.54746277
66Renin secretion_Homo sapiens_hsa049240.50848228
67Tryptophan metabolism_Homo sapiens_hsa003800.48857484
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48289729
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44443179
70Salivary secretion_Homo sapiens_hsa049700.43333624
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.42873400
72Chemical carcinogenesis_Homo sapiens_hsa052040.42456275
73Calcium signaling pathway_Homo sapiens_hsa040200.41463601
74Nitrogen metabolism_Homo sapiens_hsa009100.40639043
75Fatty acid metabolism_Homo sapiens_hsa012120.39618205
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39160582
77Colorectal cancer_Homo sapiens_hsa052100.38793491
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37539425
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37480765
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37336421
81Metabolic pathways_Homo sapiens_hsa011000.37328530
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37276367
83Dilated cardiomyopathy_Homo sapiens_hsa054140.36993670
84Retinol metabolism_Homo sapiens_hsa008300.36639469
85Vibrio cholerae infection_Homo sapiens_hsa051100.36262491
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36221064
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.35922092
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.35575034
89RNA degradation_Homo sapiens_hsa030180.34864046
90Pyrimidine metabolism_Homo sapiens_hsa002400.34809210
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34794849
92cAMP signaling pathway_Homo sapiens_hsa040240.33979382
93Ether lipid metabolism_Homo sapiens_hsa005650.33966930
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31031826
95ABC transporters_Homo sapiens_hsa020100.30729953
96MAPK signaling pathway_Homo sapiens_hsa040100.30664348
97Gastric acid secretion_Homo sapiens_hsa049710.29650304
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28115109
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26508430
100Purine metabolism_Homo sapiens_hsa002300.25632623

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