ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	4.71285432
2	protein-cofactor linkage (GO:0018065)	4.65702678
3	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.63896523
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.60244005
5	ATP synthesis coupled proton transport (GO:0015986)	4.58361066
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.58361066
7	protein complex biogenesis (GO:0070271)	4.51174854
8	proteasome assembly (GO:0043248)	4.48958276
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.31535917
10	NADH dehydrogenase complex assembly (GO:0010257)	4.31535917
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.31535917
12	mitochondrial respiratory chain complex assembly (GO:0033108)	4.27215330
13	protein neddylation (GO:0045116)	4.24887406
14	DNA deamination (GO:0045006)	4.04087772
15	protein deneddylation (GO:0000338)	3.95579901
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.94433856
17	electron transport chain (GO:0022900)	3.93612160
18	respiratory electron transport chain (GO:0022904)	3.92496630
19	behavioral response to nicotine (GO:0035095)	3.90954862
20	respiratory chain complex IV assembly (GO:0008535)	3.89909909
21	cullin deneddylation (GO:0010388)	3.82571818
22	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.70546653
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.51382726
24	cytochrome complex assembly (GO:0017004)	3.45972698
25	regulation of cilium movement (GO:0003352)	3.39574506
26	platelet dense granule organization (GO:0060155)	3.35730362
27	mannosylation (GO:0097502)	3.33600747
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.33046117
29	ubiquinone biosynthetic process (GO:0006744)	3.29478890
30	ubiquinone metabolic process (GO:0006743)	3.17946254
31	peptidyl-histidine modification (GO:0018202)	3.17842075
32	regulation of glucokinase activity (GO:0033131)	3.16635018
33	regulation of hexokinase activity (GO:1903299)	3.16635018
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.15259426
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.15259426
36	amino acid salvage (GO:0043102)	3.09774964
37	L-methionine salvage (GO:0071267)	3.09774964
38	L-methionine biosynthetic process (GO:0071265)	3.09774964
39	piRNA metabolic process (GO:0034587)	3.08504735
40	protein polyglutamylation (GO:0018095)	3.06882273
41	hydrogen ion transmembrane transport (GO:1902600)	3.06358354
42	proton transport (GO:0015992)	3.04406179
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.98371302
44	hydrogen transport (GO:0006818)	2.98156035
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.96028274
46	nonmotile primary cilium assembly (GO:0035058)	2.87387220
47	response to pheromone (GO:0019236)	2.86697493
48	GMP metabolic process (GO:0046037)	2.82479438
49	termination of RNA polymerase III transcription (GO:0006386)	2.81931754
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.81931754
51	GPI anchor metabolic process (GO:0006505)	2.80942406
52	parturition (GO:0007567)	2.71717917
53	protein localization to cilium (GO:0061512)	2.71173401
54	ATP biosynthetic process (GO:0006754)	2.68796352
55	tRNA processing (GO:0008033)	2.67440480
56	adaptation of signaling pathway (GO:0023058)	2.67433250
57	intracellular protein transmembrane import (GO:0044743)	2.66538265
58	regulation of cellular amino acid metabolic process (GO:0006521)	2.65375990
59	negative regulation of telomere maintenance (GO:0032205)	2.64307106
60	negative regulation of appetite (GO:0032099)	2.62150625
61	negative regulation of response to food (GO:0032096)	2.62150625
62	iron-sulfur cluster assembly (GO:0016226)	2.59331354
63	metallo-sulfur cluster assembly (GO:0031163)	2.59331354
64	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.59065667
65	ATP hydrolysis coupled proton transport (GO:0015991)	2.59065667
66	GPI anchor biosynthetic process (GO:0006506)	2.59025623
67	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.58832409
68	cellular ketone body metabolic process (GO:0046950)	2.58523473
69	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.57269314
70	pseudouridine synthesis (GO:0001522)	2.56349931
71	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.54599192
72	substrate-independent telencephalic tangential migration (GO:0021826)	2.54599192
73	positive regulation of mitochondrial fission (GO:0090141)	2.53608593
74	protein targeting to mitochondrion (GO:0006626)	2.53071560
75	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.52984519
76	quinone biosynthetic process (GO:1901663)	2.52427376
77	C-terminal protein lipidation (GO:0006501)	2.51178379
78	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.50403761
79	axoneme assembly (GO:0035082)	2.50253425
80	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.49905188
81	inositol phosphate dephosphorylation (GO:0046855)	2.49486966
82	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.49486966
83	cilium morphogenesis (GO:0060271)	2.49055444
84	inositol phosphate catabolic process (GO:0071545)	2.49034343
85	establishment of protein localization to mitochondrion (GO:0072655)	2.48093863
86	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.46631290
87	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.46492859
88	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.45914060
89	regulation of meiosis I (GO:0060631)	2.45229690
90	protein localization to mitochondrion (GO:0070585)	2.43449220
91	signal peptide processing (GO:0006465)	2.43335084
92	L-fucose metabolic process (GO:0042354)	2.43317406
93	L-fucose catabolic process (GO:0042355)	2.43317406
94	fucose catabolic process (GO:0019317)	2.43317406
95	male meiosis (GO:0007140)	2.41880049
96	intraciliary transport (GO:0042073)	2.40166757
97	amine catabolic process (GO:0009310)	2.39438903
98	cellular biogenic amine catabolic process (GO:0042402)	2.39438903
99	ketone body metabolic process (GO:1902224)	2.38771286
100	indolalkylamine metabolic process (GO:0006586)	2.38306864

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.16588013
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.01532580
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.52971228
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.45953193
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.34614418
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.34567589
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.88942252
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.86095285
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.72354439
10	VDR_22108803_ChIP-Seq_LS180_Human	2.62531162
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.56416783
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.43017609
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.41699972
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.37761819
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.17123244
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.08541790
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.05518752
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.98337452
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.97482405
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.96288226
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91273531
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.90084598
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89784006
24	FUS_26573619_Chip-Seq_HEK293_Human	1.82295841
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.78109636
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.77549213
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.77115271
28	EWS_26573619_Chip-Seq_HEK293_Human	1.74264644
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69718712
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66241854
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.65251592
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.64281283
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.62735450
34	P300_19829295_ChIP-Seq_ESCs_Human	1.60105717
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59043951
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.56260740
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.52409578
38	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.49598672
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48671305
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48187616
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44468932
42	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.42054723
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36321992
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35048882
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.34864251
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34615242
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34416540
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32560476
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.29013314
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.27915673
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24941243
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24941243
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.24842584
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23480832
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23480832
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23024237
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17006140
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16600841
59	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16538209
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16091844
61	DCP1A_22483619_ChIP-Seq_HELA_Human	1.15334720
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12896716
63	AR_20517297_ChIP-Seq_VCAP_Human	1.11463007
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11369025
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11020969
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.11020969
67	NCOR_22424771_ChIP-Seq_293T_Human	1.10099222
68	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.09560259
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.08374119
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05687397
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05212840
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04584778
73	HTT_18923047_ChIP-ChIP_STHdh_Human	1.03177791
74	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.01556996
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00067359
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.98865432
77	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.98610852
78	TTF2_22483619_ChIP-Seq_HELA_Human	0.98337458
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96466728
80	TCF4_22108803_ChIP-Seq_LS180_Human	0.96161356
81	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92121165
82	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91995779
83	MYC_19829295_ChIP-Seq_ESCs_Human	0.91335267
84	AR_25329375_ChIP-Seq_VCAP_Human	0.89971213
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89238555
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.88326817
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.87987617
88	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.87327649
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.87094547
90	SMAD4_21799915_ChIP-Seq_A2780_Human	0.87017365
91	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.86673782
92	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86369058
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.86318201
94	REST_21632747_ChIP-Seq_MESCs_Mouse	0.86118114
95	NANOG_20526341_ChIP-Seq_ESCs_Human	0.85392536
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85380578
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.85348615
98	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84815219
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.84535298
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.83801000

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.86829428
2	MP0002638_abnormal_pupillary_reflex	2.85579134
3	MP0002102_abnormal_ear_morphology	2.81561449
4	MP0002837_dystrophic_cardiac_calcinosis	2.33781468
5	MP0003787_abnormal_imprinting	2.32325698
6	MP0003880_abnormal_central_pattern	2.21862983
7	MP0006072_abnormal_retinal_apoptosis	2.21206202
8	MP0000372_irregular_coat_pigmentation	2.19124563
9	MP0005084_abnormal_gallbladder_morpholo	2.15644082
10	MP0001529_abnormal_vocalization	2.11286368
11	MP0001984_abnormal_olfaction	2.06352014
12	MP0008058_abnormal_DNA_repair	2.04168655
13	MP0008875_abnormal_xenobiotic_pharmacok	1.97283550
14	MP0005551_abnormal_eye_electrophysiolog	1.94238014
15	MP0003136_yellow_coat_color	1.93187909
16	MP0004133_heterotaxia	1.92935342
17	MP0004142_abnormal_muscle_tone	1.92131452
18	MP0009046_muscle_twitch	1.90592377
19	MP0002160_abnormal_reproductive_system	1.85251769
20	MP0003646_muscle_fatigue	1.83795568
21	MP0003011_delayed_dark_adaptation	1.82673581
22	MP0002163_abnormal_gland_morphology	1.81329959
23	MP0003195_calcinosis	1.81190855
24	MP0006276_abnormal_autonomic_nervous	1.79610044
25	MP0003186_abnormal_redox_activity	1.73544244
26	MP0004147_increased_porphyrin_level	1.73392953
27	MP0008872_abnormal_physiological_respon	1.71203202
28	MP0005645_abnormal_hypothalamus_physiol	1.70578297
29	MP0002277_abnormal_respiratory_mucosa	1.68810967
30	MP0005253_abnormal_eye_physiology	1.67383074
31	MP0006036_abnormal_mitochondrial_physio	1.66522899
32	MP0002736_abnormal_nociception_after	1.65137543
33	MP0010386_abnormal_urinary_bladder	1.64207000
34	MP0005646_abnormal_pituitary_gland	1.63163117
35	MP0005389_reproductive_system_phenotype	1.62521039
36	MP0002272_abnormal_nervous_system	1.61239121
37	MP0002876_abnormal_thyroid_physiology	1.55591318
38	MP0003806_abnormal_nucleotide_metabolis	1.53991123
39	MP0003122_maternal_imprinting	1.53770176
40	MP0001905_abnormal_dopamine_level	1.52832876
41	MP0001968_abnormal_touch/_nociception	1.52301667
42	MP0003121_genomic_imprinting	1.50617367
43	MP0009745_abnormal_behavioral_response	1.49257627
44	MP0001919_abnormal_reproductive_system	1.47406118
45	MP0005379_endocrine/exocrine_gland_phen	1.46028870
46	MP0002938_white_spotting	1.45570616
47	MP0001986_abnormal_taste_sensitivity	1.40831092
48	MP0003718_maternal_effect	1.37914375
49	MP0008789_abnormal_olfactory_epithelium	1.34290601
50	MP0006035_abnormal_mitochondrial_morpho	1.34174826
51	MP0006292_abnormal_olfactory_placode	1.28648130
52	MP0000647_abnormal_sebaceous_gland	1.27711525
53	MP0005423_abnormal_somatic_nervous	1.26866218
54	MP0002928_abnormal_bile_duct	1.26435642
55	MP0002822_catalepsy	1.23291606
56	MP0005410_abnormal_fertilization	1.22100979
57	MP0008995_early_reproductive_senescence	1.20387884
58	MP0002090_abnormal_vision	1.16424861
59	MP0004043_abnormal_pH_regulation	1.15944130
60	MP0002557_abnormal_social/conspecific_i	1.15582351
61	MP0001485_abnormal_pinna_reflex	1.14855616
62	MP0001764_abnormal_homeostasis	1.13505391
63	MP0003786_premature_aging	1.11801133
64	MP0000631_abnormal_neuroendocrine_gland	1.10626450
65	MP0002653_abnormal_ependyma_morphology	1.09573918
66	MP0002572_abnormal_emotion/affect_behav	1.06025297
67	MP0002234_abnormal_pharynx_morphology	1.04540884
68	MP0001970_abnormal_pain_threshold	1.03938014
69	MP0004742_abnormal_vestibular_system	1.02432587
70	MP0004145_abnormal_muscle_electrophysio	1.01177850
71	MP0004215_abnormal_myocardial_fiber	0.97705182
72	MP0000639_abnormal_adrenal_gland	0.97157304
73	MP0001486_abnormal_startle_reflex	0.96258445
74	MP0001188_hyperpigmentation	0.95087896
75	MP0002210_abnormal_sex_determination	0.94998449
76	MP0002064_seizures	0.94371899
77	MP0005195_abnormal_posterior_eye	0.94249407
78	MP0005187_abnormal_penis_morphology	0.93708892
79	MP0002751_abnormal_autonomic_nervous	0.93247335
80	MP0005394_taste/olfaction_phenotype	0.91604903
81	MP0005499_abnormal_olfactory_system	0.91604903
82	MP0002138_abnormal_hepatobiliary_system	0.91577391
83	MP0003123_paternal_imprinting	0.89230124
84	MP0002733_abnormal_thermal_nociception	0.88445100
85	MP0000427_abnormal_hair_cycle	0.87698770
86	MP0005075_abnormal_melanosome_morpholog	0.87067714
87	MP0001929_abnormal_gametogenesis	0.86901300
88	MP0004885_abnormal_endolymph	0.86021957
89	MP0001501_abnormal_sleep_pattern	0.85702870
90	MP0005332_abnormal_amino_acid	0.85515734
91	MP0008775_abnormal_heart_ventricle	0.85124044
92	MP0002229_neurodegeneration	0.85113925
93	MP0002909_abnormal_adrenal_gland	0.84686988
94	MP0005386_behavior/neurological_phenoty	0.81916056
95	MP0004924_abnormal_behavior	0.81916056
96	MP0002095_abnormal_skin_pigmentation	0.80522456
97	MP0003698_abnormal_male_reproductive	0.79135455
98	MP0002752_abnormal_somatic_nervous	0.78242349
99	MP0005174_abnormal_tail_pigmentation	0.77282003
100	MP0000653_abnormal_sex_gland	0.76581048

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.43863598
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.03411366
3	Mitochondrial inheritance (HP:0001427)	4.01442923
4	Increased CSF lactate (HP:0002490)	3.94432542
5	Progressive macrocephaly (HP:0004481)	3.93278173
6	3-Methylglutaconic aciduria (HP:0003535)	3.90132837
7	Acute encephalopathy (HP:0006846)	3.86660108
8	Hepatocellular necrosis (HP:0001404)	3.60832237
9	Methylmalonic acidemia (HP:0002912)	3.58172742
10	Hepatic necrosis (HP:0002605)	3.46341667
11	Pancreatic cysts (HP:0001737)	3.39638506
12	Congenital stationary night blindness (HP:0007642)	3.33188732
13	Molar tooth sign on MRI (HP:0002419)	3.27537947
14	Abnormality of midbrain morphology (HP:0002418)	3.27537947
15	Methylmalonic aciduria (HP:0012120)	3.24682170
16	Lipid accumulation in hepatocytes (HP:0006561)	3.12109036
17	Increased hepatocellular lipid droplets (HP:0006565)	3.10986061
18	Medial flaring of the eyebrow (HP:0010747)	2.97563697
19	Pancreatic fibrosis (HP:0100732)	2.96532829
20	True hermaphroditism (HP:0010459)	2.93071761
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.85164815
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.85164815
23	Abnormality of alanine metabolism (HP:0010916)	2.74176550
24	Hyperalaninemia (HP:0003348)	2.74176550
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.74176550
26	Increased serum lactate (HP:0002151)	2.72569957
27	Cerebral edema (HP:0002181)	2.69994698
28	Renal Fanconi syndrome (HP:0001994)	2.68008762
29	Aplasia/hypoplasia of the uterus (HP:0008684)	2.59961605
30	Optic disc pallor (HP:0000543)	2.57107686
31	Lactic acidosis (HP:0003128)	2.56724950
32	Type II lissencephaly (HP:0007260)	2.54814348
33	Nephronophthisis (HP:0000090)	2.53833253
34	Hyperglycinemia (HP:0002154)	2.52758110
35	Gait imbalance (HP:0002141)	2.37901188
36	Increased intramyocellular lipid droplets (HP:0012240)	2.36816938
37	Respiratory failure (HP:0002878)	2.35713044
38	Abolished electroretinogram (ERG) (HP:0000550)	2.32176170
39	Congenital primary aphakia (HP:0007707)	2.29626519
40	Lethargy (HP:0001254)	2.28908470
41	Nephrogenic diabetes insipidus (HP:0009806)	2.27927040
42	Abnormality of the renal cortex (HP:0011035)	2.21553410
43	CNS demyelination (HP:0007305)	2.18482306
44	Glycosuria (HP:0003076)	2.16753189
45	Abnormality of urine glucose concentration (HP:0011016)	2.16753189
46	Renal cortical cysts (HP:0000803)	2.16521896
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.15508397
48	Abnormality of the labia minora (HP:0012880)	2.13890392
49	Abnormality of the renal medulla (HP:0100957)	2.12208200
50	Abnormality of vitamin B metabolism (HP:0004340)	2.11373994
51	Polyphagia (HP:0002591)	2.11203081
52	Exertional dyspnea (HP:0002875)	2.08911911
53	Retinal dysplasia (HP:0007973)	2.05460874
54	Increased muscle lipid content (HP:0009058)	2.03135388
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.01964842
56	Hypoplasia of the uterus (HP:0000013)	2.01932307
57	Chronic hepatic failure (HP:0100626)	1.98344268
58	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.98200787
59	Hypothermia (HP:0002045)	1.97167569
60	Adrenal hypoplasia (HP:0000835)	1.96416590
61	Pendular nystagmus (HP:0012043)	1.94939043
62	Abnormality of serum amino acid levels (HP:0003112)	1.94047149
63	Congenital, generalized hypertrichosis (HP:0004540)	1.93797459
64	Sclerocornea (HP:0000647)	1.93084562
65	Stenosis of the external auditory canal (HP:0000402)	1.92078309
66	Leukodystrophy (HP:0002415)	1.87009458
67	Oligodactyly (hands) (HP:0001180)	1.86778638
68	Abnormality of renal resorption (HP:0011038)	1.85234626
69	Exercise intolerance (HP:0003546)	1.84122126
70	Dicarboxylic aciduria (HP:0003215)	1.83176658
71	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.83176658
72	Genital tract atresia (HP:0001827)	1.80794726
73	Lissencephaly (HP:0001339)	1.80422249
74	Generalized aminoaciduria (HP:0002909)	1.78415201
75	Agitation (HP:0000713)	1.77533353
76	Concave nail (HP:0001598)	1.75251177
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.74727214
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.74727214
79	Abnormal protein glycosylation (HP:0012346)	1.74727214
80	Abnormal glycosylation (HP:0012345)	1.74727214
81	Male pseudohermaphroditism (HP:0000037)	1.74389257
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73484402
83	Attenuation of retinal blood vessels (HP:0007843)	1.73464538
84	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.72929301
85	Abnormality of glycine metabolism (HP:0010895)	1.72320629
86	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72320629
87	Emotional lability (HP:0000712)	1.72054826
88	Vaginal atresia (HP:0000148)	1.72025631
89	X-linked dominant inheritance (HP:0001423)	1.68935537
90	Progressive microcephaly (HP:0000253)	1.67598716
91	Respiratory difficulties (HP:0002880)	1.66623977
92	Hyperglycinuria (HP:0003108)	1.64948639
93	Severe muscular hypotonia (HP:0006829)	1.64495178
94	Short tibia (HP:0005736)	1.62789206
95	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.61403388
96	Hypomagnesemia (HP:0002917)	1.61066638
97	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.59848292
98	Cystic liver disease (HP:0006706)	1.59584590
99	Poor suck (HP:0002033)	1.59489293
100	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.59000093

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.11842418
2	FRK	3.10271923
3	PDK2	2.63348814
4	STK16	2.48839132
5	MST4	2.32186048
6	ADRBK2	2.29365448
7	CASK	2.26528011
8	WNK3	2.14895330
9	GRK1	2.07594525
10	TAOK3	2.05486664
11	BCKDK	1.97508166
12	MAP2K7	1.95920332
13	BMPR1B	1.88245476
14	MAP3K4	1.78780624
15	NUAK1	1.76725045
16	TLK1	1.75712737
17	ZAK	1.69893604
18	TRIM28	1.64229667
19	MAP3K12	1.61672789
20	PINK1	1.59102649
21	LIMK1	1.56718417
22	DYRK2	1.56579215
23	SRPK1	1.45617735
24	WNK4	1.44706902
25	CAMKK2	1.42379429
26	INSRR	1.36855119
27	MAPK13	1.34826047
28	CSNK1G3	1.34514782
29	GRK7	1.29381691
30	CSNK1G2	1.27434365
31	PIM2	1.25184300
32	PAK3	1.22336965
33	VRK1	1.21913007
34	ERBB3	1.21370746
35	VRK2	1.19524994
36	CSNK1G1	1.19230906
37	TXK	1.18067282
38	PHKG1	1.17426711
39	PHKG2	1.17426711
40	OXSR1	1.09462310
41	CSNK1A1L	1.09230976
42	EIF2AK1	1.07201045
43	PNCK	1.00253601
44	EIF2AK3	0.99773421
45	BUB1	0.99676037
46	BCR	0.98347992
47	TESK2	0.95808103
48	PLK2	0.94232559
49	MINK1	0.93640457
50	EPHA4	0.93419352
51	MARK1	0.92133572
52	PRKCI	0.91974423
53	PRKCE	0.91303130
54	PRKCG	0.90906387
55	ADRBK1	0.89407736
56	TNIK	0.84763615
57	NEK1	0.81576463
58	TSSK6	0.81449297
59	MAP2K6	0.80962625
60	ARAF	0.78736457
61	PLK4	0.75815111
62	ABL2	0.73975004
63	NME1	0.73390703
64	ACVR1B	0.73159907
65	LMTK2	0.71636983
66	PLK3	0.71456306
67	MKNK2	0.71412357
68	RPS6KA5	0.67481314
69	CSNK1A1	0.67080404
70	IKBKB	0.66643616
71	PLK1	0.65010785
72	TESK1	0.64929253
73	MAPKAPK5	0.63282226
74	TIE1	0.60411926
75	MAPK15	0.59513846
76	STK39	0.59375607
77	CAMK2A	0.58630249
78	WEE1	0.57624635
79	MAP2K4	0.57265226
80	DAPK2	0.54853104
81	PRKACA	0.53610562
82	PKN1	0.53417343
83	MAP3K11	0.51332278
84	PRKCQ	0.48535838
85	CSNK2A1	0.47670892
86	AURKA	0.47493204
87	MUSK	0.47015552
88	OBSCN	0.46195856
89	NTRK3	0.45995202
90	GRK5	0.45940812
91	SIK2	0.45789055
92	MKNK1	0.42527826
93	CSNK2A2	0.42108036
94	PRKCA	0.38887087
95	PASK	0.37252840
96	TGFBR1	0.37039391
97	FER	0.34150685
98	ATR	0.31118110
99	PRKG1	0.30652977
100	BRSK2	0.29632787

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.26939713
2	Protein export_Homo sapiens_hsa03060	3.47747985
3	Parkinsons disease_Homo sapiens_hsa05012	3.36001333
4	Proteasome_Homo sapiens_hsa03050	3.20248265
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.52796446
6	Ribosome_Homo sapiens_hsa03010	2.48971347
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.37259789
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.31531427
9	Huntingtons disease_Homo sapiens_hsa05016	2.23231606
10	Alzheimers disease_Homo sapiens_hsa05010	2.19915881
11	RNA polymerase_Homo sapiens_hsa03020	2.10351572
12	Collecting duct acid secretion_Homo sapiens_hsa04966	2.05125390
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.95114684
14	Basal transcription factors_Homo sapiens_hsa03022	1.81589906
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73156578
16	Sulfur metabolism_Homo sapiens_hsa00920	1.71875309
17	Phototransduction_Homo sapiens_hsa04744	1.68236929
18	Butanoate metabolism_Homo sapiens_hsa00650	1.64273933
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.62842839
20	Homologous recombination_Homo sapiens_hsa03440	1.62241365
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.58705719
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.54835433
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48473143
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.45819476
25	Propanoate metabolism_Homo sapiens_hsa00640	1.41458988
26	Caffeine metabolism_Homo sapiens_hsa00232	1.39858714
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.37982338
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37399396
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34824501
30	Fatty acid elongation_Homo sapiens_hsa00062	1.33932234
31	RNA degradation_Homo sapiens_hsa03018	1.32544570
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.28764345
33	Peroxisome_Homo sapiens_hsa04146	1.26842433
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.25107314
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.21798786
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17185894
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13570585
38	One carbon pool by folate_Homo sapiens_hsa00670	1.11178669
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.10589451
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.09254708
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.08947293
42	Nicotine addiction_Homo sapiens_hsa05033	1.08510009
43	Regulation of autophagy_Homo sapiens_hsa04140	1.01261830
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.98919174
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98180481
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94564358
47	Mismatch repair_Homo sapiens_hsa03430	0.91139685
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91081045
49	Purine metabolism_Homo sapiens_hsa00230	0.90985347
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90691549
51	Metabolic pathways_Homo sapiens_hsa01100	0.88347099
52	Folate biosynthesis_Homo sapiens_hsa00790	0.87975258
53	Glutathione metabolism_Homo sapiens_hsa00480	0.85322650
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84983672
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83966743
56	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83853825
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83063019
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81165786
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80847384
60	Sulfur relay system_Homo sapiens_hsa04122	0.77786243
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.77430456
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72923114
63	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.72307471
64	Retinol metabolism_Homo sapiens_hsa00830	0.68470200
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67797492
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67763564
67	Spliceosome_Homo sapiens_hsa03040	0.66527751
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.63807055
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.63166480
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62727745
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61534819
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61019528
73	Mineral absorption_Homo sapiens_hsa04978	0.60783651
74	RNA transport_Homo sapiens_hsa03013	0.59094338
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58561393
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56144767
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.56094791
78	GABAergic synapse_Homo sapiens_hsa04727	0.51490421
79	Taste transduction_Homo sapiens_hsa04742	0.51379458
80	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.50990825
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50364881
82	Olfactory transduction_Homo sapiens_hsa04740	0.50180936
83	Base excision repair_Homo sapiens_hsa03410	0.49975942
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.48709558
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48446453
86	Morphine addiction_Homo sapiens_hsa05032	0.46531179
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44061613
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.39788316
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37671649
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37304587
91	DNA replication_Homo sapiens_hsa03030	0.37296834
92	Asthma_Homo sapiens_hsa05310	0.32640822
93	Fatty acid degradation_Homo sapiens_hsa00071	0.31941960
94	Serotonergic synapse_Homo sapiens_hsa04726	0.31085980
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.30017254
96	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29800495
97	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29736216
98	Insulin secretion_Homo sapiens_hsa04911	0.27809311
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26590153
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.26318070

TRAPPC2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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