TRAPPC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.08919345
2Golgi transport vesicle coating (GO:0048200)6.08919345
3protein maturation by protein folding (GO:0022417)4.87860708
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.55970186
5pentose-phosphate shunt (GO:0006098)4.25324965
6NADH metabolic process (GO:0006734)4.16437875
7lysine metabolic process (GO:0006553)3.92816786
8lysine catabolic process (GO:0006554)3.92816786
9NADPH regeneration (GO:0006740)3.89478982
10tricarboxylic acid cycle (GO:0006099)3.83069150
11regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.80199660
12tricarboxylic acid metabolic process (GO:0072350)3.75403474
132-oxoglutarate metabolic process (GO:0006103)3.70505461
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.68025872
15oxaloacetate metabolic process (GO:0006107)3.67702402
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.62675744
17alpha-linolenic acid metabolic process (GO:0036109)3.61657541
18GDP-mannose metabolic process (GO:0019673)3.61126291
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.57858618
20L-phenylalanine metabolic process (GO:0006558)3.57858618
21NIK/NF-kappaB signaling (GO:0038061)3.55484905
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55294895
23low-density lipoprotein particle clearance (GO:0034383)3.53889900
24protein retention in ER lumen (GO:0006621)3.51613942
25regulation of cholesterol homeostasis (GO:2000188)3.37968550
26negative regulation of cell size (GO:0045792)3.37189857
27maturation of SSU-rRNA (GO:0030490)3.36218186
28sulfur amino acid catabolic process (GO:0000098)3.28910314
29iron-sulfur cluster assembly (GO:0016226)3.22739814
30metallo-sulfur cluster assembly (GO:0031163)3.22739814
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22549321
32growth hormone secretion (GO:0030252)3.22079490
33activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.21539506
34regulation of fatty acid beta-oxidation (GO:0031998)3.20556665
35mitotic nuclear envelope reassembly (GO:0007084)3.19075719
36nuclear envelope reassembly (GO:0031468)3.19075719
37L-phenylalanine catabolic process (GO:0006559)3.17468653
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.17468653
39succinate metabolic process (GO:0006105)3.16837692
402-deoxyribonucleotide biosynthetic process (GO:0009265)3.15563989
41deoxyribose phosphate biosynthetic process (GO:0046385)3.15563989
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15385569
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.14464366
44vesicle coating (GO:0006901)3.08435029
45nucleobase-containing small molecule interconversion (GO:0015949)3.07385093
46positive regulation of nuclease activity (GO:0032075)3.05613766
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.04991802
48regulation of early endosome to late endosome transport (GO:2000641)3.04428969
49barbed-end actin filament capping (GO:0051016)3.03345367
50sodium ion export (GO:0071436)3.03020684
51regulation of cholesterol storage (GO:0010885)3.00562368
52lipopolysaccharide biosynthetic process (GO:0009103)2.99622011
53negative regulation of microtubule polymerization (GO:0031115)2.99394893
54regulation of mitochondrial translation (GO:0070129)2.99336447
55pentose metabolic process (GO:0019321)2.96511828
56ribosomal small subunit biogenesis (GO:0042274)2.95690814
57negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.94413762
58glucose catabolic process (GO:0006007)2.93849573
59positive regulation of triglyceride biosynthetic process (GO:0010867)2.93432627
60protein targeting to mitochondrion (GO:0006626)2.93227282
61apoptotic cell clearance (GO:0043277)2.92264040
62cellular ketone body metabolic process (GO:0046950)2.90972525
63cerebellar Purkinje cell layer development (GO:0021680)2.89731357
64nucleotide salvage (GO:0043173)2.89649070
65heme biosynthetic process (GO:0006783)2.88973361
66aspartate family amino acid catabolic process (GO:0009068)2.88499715
67regulation of translational termination (GO:0006449)2.87705243
68ATP hydrolysis coupled proton transport (GO:0015991)2.85271132
69energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.85271132
70regulation of fatty acid oxidation (GO:0046320)2.84906281
71chaperone-mediated protein transport (GO:0072321)2.83308641
72valine metabolic process (GO:0006573)2.82587613
73cysteine metabolic process (GO:0006534)2.81971116
74positive regulation of monocyte chemotaxis (GO:0090026)2.81124839
75gluconeogenesis (GO:0006094)2.80865401
76pyrimidine-containing compound salvage (GO:0008655)2.80563592
77pyrimidine nucleoside salvage (GO:0043097)2.80563592
78positive regulation of fatty acid biosynthetic process (GO:0045723)2.78505930
79heme metabolic process (GO:0042168)2.78186285
80monosaccharide biosynthetic process (GO:0046364)2.76846822
81antigen processing and presentation of endogenous antigen (GO:0019883)2.76511703
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75058047
83fructose metabolic process (GO:0006000)2.74535802
84proteasome assembly (GO:0043248)2.73636134
85lipopolysaccharide metabolic process (GO:0008653)2.73313673
86hexose biosynthetic process (GO:0019319)2.72103564
87regulation of cellular amino acid metabolic process (GO:0006521)2.72032716
88virion assembly (GO:0019068)2.71470227
89macroautophagy (GO:0016236)2.70894709
90cellular modified amino acid catabolic process (GO:0042219)2.70614282
91endoplasmic reticulum unfolded protein response (GO:0030968)2.70367713
92amyloid precursor protein catabolic process (GO:0042987)2.70235758
93regulation of nuclease activity (GO:0032069)2.69008987
94establishment of protein localization to mitochondrion (GO:0072655)2.68921933
95glycosphingolipid catabolic process (GO:0046479)2.67747280
96purine nucleotide salvage (GO:0032261)2.67335702
97CDP-diacylglycerol metabolic process (GO:0046341)2.66537482
98oxidative phosphorylation (GO:0006119)2.64806799
99cell communication by electrical coupling (GO:0010644)2.64540764
100positive regulation of fatty acid metabolic process (GO:0045923)2.64064797
101transferrin transport (GO:0033572)2.63125327
1024-hydroxyproline metabolic process (GO:0019471)2.61308792
103positive regulation of fatty acid oxidation (GO:0046321)2.60761985
104purine deoxyribonucleotide catabolic process (GO:0009155)2.60608837
105cellular response to unfolded protein (GO:0034620)2.56562073
106proline biosynthetic process (GO:0006561)2.56218760
107protein insertion into membrane (GO:0051205)2.56156550
108nucleoside salvage (GO:0043174)2.55944654
109antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.55094974
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.54917902
111positive regulation of fatty acid beta-oxidation (GO:0032000)2.54165629
112negative regulation of fibrinolysis (GO:0051918)2.53072438
113peptidyl-arginine omega-N-methylation (GO:0035247)2.52818015
114pinocytosis (GO:0006907)2.51663851
115negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50997732
116ketone body metabolic process (GO:1902224)2.50564189
117amino sugar catabolic process (GO:0046348)2.50404597
118mitochondrial calcium ion transport (GO:0006851)2.50138032
119ER-nucleus signaling pathway (GO:0006984)2.49811533
120positive regulation of receptor biosynthetic process (GO:0010870)2.48566976
121triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.48562044
122positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.48382108
123positive regulation of triglyceride metabolic process (GO:0090208)2.48066852
124NADP metabolic process (GO:0006739)2.48053080
125galactose catabolic process (GO:0019388)2.47747664
126establishment of viral latency (GO:0019043)2.47197712
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.47069415
128negative regulation of ligase activity (GO:0051352)2.47069415
129mannose metabolic process (GO:0006013)2.46312919
130plasma lipoprotein particle clearance (GO:0034381)2.45957235
131guanosine-containing compound biosynthetic process (GO:1901070)2.45873615
132glycolipid catabolic process (GO:0019377)2.45418399
133protein localization to mitochondrion (GO:0070585)2.45197177
134nitric oxide biosynthetic process (GO:0006809)2.44708221
135cellular response to topologically incorrect protein (GO:0035967)2.44469456
136synaptic vesicle maturation (GO:0016188)2.44404241
137ethanol oxidation (GO:0006069)2.43684282
138fatty acid homeostasis (GO:0055089)2.43664902
139regulation of mitochondrial membrane potential (GO:0051881)2.42127748
140mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.41333170
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.40984739
142negative regulation of lipid transport (GO:0032369)2.40958256
143negative regulation of myeloid cell apoptotic process (GO:0033033)2.39199012
144regulation of synapse structural plasticity (GO:0051823)2.38846053
145trivalent inorganic cation transport (GO:0072512)2.38644582
146ferric iron transport (GO:0015682)2.38644582
147fatty acid beta-oxidation (GO:0006635)2.38393474
148dicarboxylic acid biosynthetic process (GO:0043650)2.38347882
149protein targeting to plasma membrane (GO:0072661)2.38164636
150viral protein processing (GO:0019082)2.37567840
151antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.36830912
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.36830912
153regulation of superoxide anion generation (GO:0032928)2.36635602
154glyoxylate metabolic process (GO:0046487)2.36512410
155activation of protein kinase A activity (GO:0034199)2.35211497
156synaptic vesicle docking involved in exocytosis (GO:0016081)2.34997714
157regulation of tight junction assembly (GO:2000810)2.34892977
158kynurenine metabolic process (GO:0070189)2.34301699
159chaperone mediated protein folding requiring cofactor (GO:0051085)2.34163432
160endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.34099512
161glutamate metabolic process (GO:0006536)2.33715083
162actin nucleation (GO:0045010)2.33338484
163deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.33176665
164deoxyribonucleotide biosynthetic process (GO:0009263)2.32636526
165cellular response to arsenic-containing substance (GO:0071243)2.32340131
166UV protection (GO:0009650)2.31630466
167nucleoside diphosphate biosynthetic process (GO:0009133)2.31511576
168cellular response to nutrient (GO:0031670)2.31371348
169protoporphyrinogen IX metabolic process (GO:0046501)2.31052123
170positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.30684492
171de novo posttranslational protein folding (GO:0051084)2.30467610
172deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.30045661
173acetyl-CoA metabolic process (GO:0006084)2.29526430
174positive regulation of lamellipodium assembly (GO:0010592)2.28889703
175epoxygenase P450 pathway (GO:0019373)2.28234617
176protein carboxylation (GO:0018214)2.28184607
177DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.27908557
178ceramide catabolic process (GO:0046514)2.27066260
179formation of translation preinitiation complex (GO:0001731)2.26626357
180mitochondrial fusion (GO:0008053)2.25019658
181deoxyribonucleotide catabolic process (GO:0009264)2.24268300
182phagosome maturation (GO:0090382)2.24191944
183regulation of release of cytochrome c from mitochondria (GO:0090199)2.23601950
184pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.22493342
185ATP synthesis coupled proton transport (GO:0015986)2.21972664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84175047
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.24262142
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.07399376
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.00376589
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.95036340
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93638682
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91854810
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85730224
9CLOCK_20551151_ChIP-Seq_293T_Human2.79167631
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74253754
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68213558
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.33152709
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.29117713
14LXR_22292898_ChIP-Seq_THP-1_Human2.25851167
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25619286
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15000120
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.11354186
18ZNF263_19887448_ChIP-Seq_K562_Human2.07457332
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.06926947
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05647971
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99959672
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98991577
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96286622
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90990771
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.90835324
26* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89499801
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.87627149
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.86912669
29* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86430588
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84541406
31XRN2_22483619_ChIP-Seq_HELA_Human1.83564106
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81467457
33DCP1A_22483619_ChIP-Seq_HELA_Human1.80160959
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78981672
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77445106
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.75700139
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74694818
38* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73787517
39* GABP_19822575_ChIP-Seq_HepG2_Human1.68663790
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68421136
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67820339
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.64642612
43ATF3_27146783_Chip-Seq_COLON_Human1.62471334
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62297050
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62124404
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61884094
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61002938
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.60272763
49MYC_22102868_ChIP-Seq_BL_Human1.54041110
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53898429
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.53798217
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52776690
53VDR_21846776_ChIP-Seq_THP-1_Human1.49980719
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48807291
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47488133
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44882773
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44463063
58* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43352632
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42850995
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41767241
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.41258629
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39655453
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38688168
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37270966
65* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36875074
66* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35297741
67P68_20966046_ChIP-Seq_HELA_Human1.33996396
68* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33872531
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.33689924
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33648908
71KDM2B_26808549_Chip-Seq_DND41_Human1.33526082
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33481978
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32635458
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30131254
75GATA1_22025678_ChIP-Seq_K562_Human1.27904405
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27858523
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27613832
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.27396671
79* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27227184
80GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.26102312
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.25319081
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24605390
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24527627
84VDR_23849224_ChIP-Seq_CD4+_Human1.23978814
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23237528
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.23205461
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22918590
88FOXP3_21729870_ChIP-Seq_TREG_Human1.22880773
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22448818
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21945041
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21499065
92* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20896149
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19967689
94BCOR_27268052_Chip-Seq_Bcells_Human1.18653815
95* TTF2_22483619_ChIP-Seq_HELA_Human1.17231284
96CREB1_26743006_Chip-Seq_LNCaP_Human1.16875229
97SMC4_20622854_ChIP-Seq_HELA_Human1.16428994
98* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14971923
99* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14547105
100STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14276326
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13541575
102* SPI1_23547873_ChIP-Seq_NB4_Human1.11254369
103* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11193328
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11027362
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.10789348
106* BCL6_27268052_Chip-Seq_Bcells_Human1.10555275
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10398203
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09718039
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.09367224
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09205848
111* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09125267
112* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07415176
113* MAF_26560356_Chip-Seq_TH2_Human1.07373636
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06565805
115HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06331836
116CIITA_25753668_ChIP-Seq_RAJI_Human1.05429705
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05348583
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05276138
119TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05237002
120IRF8_21731497_ChIP-ChIP_J774_Mouse1.05194792
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05160133
122* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04040548
123* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04003582
124* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03861666
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03749155
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02891254
127NCOR1_26117541_ChIP-Seq_K562_Human1.02072023
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01527358
129MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01263935
130CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00690947
131* MAF_26560356_Chip-Seq_TH1_Human1.00496905
132* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00190106
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00005336
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99862732
135* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99225620
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97880013
137* TFEB_21752829_ChIP-Seq_HELA_Human0.97552090
138* CTCF_21964334_Chip-Seq_Bcells_Human0.97493459
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97109316
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97087984
141KDM2B_26808549_Chip-Seq_K562_Human0.96205373
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96164625
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94912623
144SA1_27219007_Chip-Seq_ERYTHROID_Human0.94287827
145RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93772856
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93528390
147PHF8_20622854_ChIP-Seq_HELA_Human0.92674968
148* UTX_26944678_Chip-Seq_JUKART_Human0.92537209
149OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92435814
150CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91574793
151* FOXP1_21924763_ChIP-Seq_HESCs_Human0.91422804
152KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90026576
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.89378466
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88705095
155* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88694195
156NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88132181
157TCF7_22412390_ChIP-Seq_EML_Mouse0.88062072
158* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87455615
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86832498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.03425906
2MP0003705_abnormal_hypodermis_morpholog3.51304785
3MP0008260_abnormal_autophagy3.22930952
4MP0008438_abnormal_cutaneous_collagen3.21909374
5MP0005058_abnormal_lysosome_morphology3.00812570
6MP0000013_abnormal_adipose_tissue2.98616575
7MP0002139_abnormal_hepatobiliary_system2.92401787
8MP0005360_urolithiasis2.85058097
9MP0005451_abnormal_body_composition2.44920938
10MP0009333_abnormal_splenocyte_physiolog2.39831603
11MP0005365_abnormal_bile_salt2.37184205
12MP0003329_amyloid_beta_deposits2.29500177
13MP0003436_decreased_susceptibility_to2.24436956
14MP0004130_abnormal_muscle_cell2.17570966
15MP0008875_abnormal_xenobiotic_pharmacok2.16281120
16MP0003806_abnormal_nucleotide_metabolis2.12806994
17MP0000604_amyloidosis2.10809198
18MP0002148_abnormal_hypersensitivity_rea2.08637969
19MP0010329_abnormal_lipoprotein_level2.01148172
20MP0002909_abnormal_adrenal_gland2.00630334
21MP0003191_abnormal_cellular_cholesterol1.97125635
22MP0001835_abnormal_antigen_presentation1.96999857
23MP0009785_altered_susceptibility_to1.96388555
24MP0005275_abnormal_skin_tensile1.87824549
25MP0001542_abnormal_bone_strength1.81798071
26MP0001958_emphysema1.80162858
27MP0001661_extended_life_span1.79086829
28MP0005025_abnormal_response_to1.76257500
29MP0001853_heart_inflammation1.70289124
30MP0005332_abnormal_amino_acid1.69174364
31MP0002419_abnormal_innate_immunity1.68241739
32MP0003300_gastrointestinal_ulcer1.66888543
33MP0001756_abnormal_urination1.66648602
34MP0004859_abnormal_synaptic_plasticity1.63892812
35MP0005000_abnormal_immune_tolerance1.63180578
36MP0005083_abnormal_biliary_tract1.62890278
37MP0002837_dystrophic_cardiac_calcinosis1.62740077
38MP0005085_abnormal_gallbladder_physiolo1.55626626
39MP0006082_CNS_inflammation1.55498551
40MP0009643_abnormal_urine_homeostasis1.53904668
41MP0003172_abnormal_lysosome_physiology1.53000062
42MP0000003_abnormal_adipose_tissue1.48137381
43MP0003786_premature_aging1.43939019
44MP0000678_abnormal_parathyroid_gland1.42092984
45MP0003252_abnormal_bile_duct1.41437430
46MP0003566_abnormal_cell_adhesion1.41203088
47MP0001727_abnormal_embryo_implantation1.40233531
48MP0002452_abnormal_antigen_presenting1.38816478
49MP0002723_abnormal_immune_serum1.37836402
50MP0000685_abnormal_immune_system1.37572209
51MP0005666_abnormal_adipose_tissue1.36979010
52MP0005165_increased_susceptibility_to1.36644663
53MP0005501_abnormal_skin_physiology1.36497961
54MP0005670_abnormal_white_adipose1.35938557
55MP0004084_abnormal_cardiac_muscle1.35754303
56MP0003195_calcinosis1.33901177
57MP0006054_spinal_hemorrhage1.33487926
58MP0002420_abnormal_adaptive_immunity1.31962521
59MP0010352_gastrointestinal_tract_polyps1.31960956
60MP0001819_abnormal_immune_cell1.31931817
61MP0002118_abnormal_lipid_homeostasis1.30814288
62MP0000609_abnormal_liver_physiology1.30526464
63MP0003656_abnormal_erythrocyte_physiolo1.30313276
64MP0004858_abnormal_nervous_system1.30285604
65MP0001845_abnormal_inflammatory_respons1.30171457
66MP0008469_abnormal_protein_level1.29786296
67MP0003279_aneurysm1.28329555
68MP0005319_abnormal_enzyme/_coenzyme1.27884313
69MP0004019_abnormal_vitamin_homeostasis1.27678949
70MP0005584_abnormal_enzyme/coenzyme_acti1.27468524
71MP0005375_adipose_tissue_phenotype1.26565887
72MP0002090_abnormal_vision1.26444396
73MP0003075_altered_response_to1.26152250
74MP0008961_abnormal_basal_metabolism1.24221746
75MP0010234_abnormal_vibrissa_follicle1.21981624
76MP0003724_increased_susceptibility_to1.21325717
77MP0005257_abnormal_intraocular_pressure1.19924200
78MP0000681_abnormal_thyroid_gland1.19626194
79MP0005023_abnormal_wound_healing1.19030837
80MP0000750_abnormal_muscle_regeneration1.18308952
81MP0001764_abnormal_homeostasis1.17383324
82MP0001666_abnormal_nutrient_absorption1.17228000
83MP0002089_abnormal_postnatal_growth/wei1.17186788
84MP0002877_abnormal_melanocyte_morpholog1.16048718
85MP0002796_impaired_skin_barrier1.15204110
86MP0001790_abnormal_immune_system1.14727664
87MP0005387_immune_system_phenotype1.14727664
88MP0004233_abnormal_muscle_weight1.13008977
89MP0000751_myopathy1.07445521
90MP0003453_abnormal_keratinocyte_physiol1.06861689
91MP0003448_altered_tumor_morphology1.06778197
92MP0003763_abnormal_thymus_physiology1.06759144
93MP0002405_respiratory_system_inflammati1.06757726
94MP0005671_abnormal_response_to1.06683915
95MP0000343_altered_response_to1.03679823
96MP0002429_abnormal_blood_cell1.03117887
97MP0004147_increased_porphyrin_level1.02976715
98MP0003186_abnormal_redox_activity1.02243298
99MP0000747_muscle_weakness1.02214348
100MP0001800_abnormal_humoral_immune1.01499890
101MP0000358_abnormal_cell_content/1.01059151
102MP0000716_abnormal_immune_system1.00710826
103MP0004947_skin_inflammation1.00513485
104MP0002722_abnormal_immune_system0.99144853
105MP0002132_abnormal_respiratory_system0.99060816
106MP0002060_abnormal_skin_morphology0.98664655
107MP0009764_decreased_sensitivity_to0.98438043
108MP0004185_abnormal_adipocyte_glucose0.97348543
109MP0003879_abnormal_hair_cell0.95535121
110MP0009763_increased_sensitivity_to0.95425567
111MP0001243_abnormal_dermal_layer0.95056369
112MP0002078_abnormal_glucose_homeostasis0.94042453
113MP0002398_abnormal_bone_marrow0.93989770
114MP0008775_abnormal_heart_ventricle0.93507929
115MP0002998_abnormal_bone_remodeling0.93112822
116MP0001849_ear_inflammation0.92962837
117MP0006036_abnormal_mitochondrial_physio0.92784969
118MP0003303_peritoneal_inflammation0.92569279
119MP0001545_abnormal_hematopoietic_system0.91857015
120MP0005397_hematopoietic_system_phenotyp0.91857015
121MP0010155_abnormal_intestine_physiology0.91118710
122MP0001216_abnormal_epidermal_layer0.90703944
123MP0000598_abnormal_liver_morphology0.86928820
124MP0001881_abnormal_mammary_gland0.86734469
125MP0003693_abnormal_embryo_hatching0.86640207
126MP0005187_abnormal_penis_morphology0.86390532
127MP0003638_abnormal_response/metabolism_0.85527946
128MP0000689_abnormal_spleen_morphology0.84823223
129MP0003283_abnormal_digestive_organ0.84599537
130MP0009780_abnormal_chondrocyte_physiolo0.84358217
131MP0009384_cardiac_valve_regurgitation0.84213750
132MP0000490_abnormal_crypts_of0.84044586
133MP0002896_abnormal_bone_mineralization0.81261491
134MP0002269_muscular_atrophy0.81053073
135MP0000313_abnormal_cell_death0.80615415
136MP0008874_decreased_physiological_sensi0.80375258
137MP0000015_abnormal_ear_pigmentation0.80174939
138MP0005330_cardiomyopathy0.79723753
139MP0009278_abnormal_bone_marrow0.78036473
140MP0004510_myositis0.77702158
141MP0004043_abnormal_pH_regulation0.77611667
142MP0005623_abnormal_meninges_morphology0.76388556
143MP0004957_abnormal_blastocyst_morpholog0.75360048
144MP0001765_abnormal_ion_homeostasis0.75330107
145MP0008932_abnormal_embryonic_tissue0.75044744
146MP0002970_abnormal_white_adipose0.73290097
147MP0005636_abnormal_mineral_homeostasis0.73252748
148MP0001299_abnormal_eye_distance/0.72165675
149MP0003221_abnormal_cardiomyocyte_apopto0.72157406
150MP0004087_abnormal_muscle_fiber0.71402207
151MP0002136_abnormal_kidney_physiology0.71259876
152MP0001533_abnormal_skeleton_physiology0.71121682
153MP0003183_abnormal_peptide_metabolism0.70660395
154MP0003091_abnormal_cell_migration0.70073310
155MP0003646_muscle_fatigue0.69656533
156MP0005464_abnormal_platelet_physiology0.69513766
157MP0001348_abnormal_lacrimal_gland0.69188222
158MP0004036_abnormal_muscle_relaxation0.65773290
159MP0010386_abnormal_urinary_bladder0.65747565
160MP0006035_abnormal_mitochondrial_morpho0.65324240
161MP0009642_abnormal_blood_homeostasis0.65093381
162MP0000858_altered_metastatic_potential0.65027924
163MP0005503_abnormal_tendon_morphology0.64493869
164MP0005166_decreased_susceptibility_to0.63930443

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.48316312
2Increased cerebral lipofuscin (HP:0011813)3.43430717
3Ragged-red muscle fibers (HP:0003200)3.42773303
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05775888
5Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05775888
6Abnormal mitochondria in muscle tissue (HP:0008316)2.98269336
7Xanthomatosis (HP:0000991)2.96058449
8Premature rupture of membranes (HP:0001788)2.92332158
9Gout (HP:0001997)2.87635432
10Hypertensive crisis (HP:0100735)2.84058443
11Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83831796
12Hand muscle atrophy (HP:0009130)2.79298593
13Deep venous thrombosis (HP:0002625)2.72205855
14Hypoglycemic coma (HP:0001325)2.71901805
15Cerebral aneurysm (HP:0004944)2.69145698
16Increased neuronal autofluorescent lipopigment (HP:0002074)2.68858807
17Acute necrotizing encephalopathy (HP:0006965)2.68486040
18Dysostosis multiplex (HP:0000943)2.66848340
19Progressive neurologic deterioration (HP:0002344)2.64807723
20Upper limb amyotrophy (HP:0009129)2.61852763
21Distal upper limb amyotrophy (HP:0007149)2.61852763
22Ketosis (HP:0001946)2.61239182
23Ketoacidosis (HP:0001993)2.58898208
24Pheochromocytoma (HP:0002666)2.56440897
25Hepatosplenomegaly (HP:0001433)2.54271934
26Abnormality of macrophages (HP:0004311)2.51751005
27Progressive muscle weakness (HP:0003323)2.43556060
28Type I transferrin isoform profile (HP:0003642)2.41932800
29Rough bone trabeculation (HP:0100670)2.41834193
30Polygenic inheritance (HP:0010982)2.41373521
31Petechiae (HP:0000967)2.40504397
32Microvesicular hepatic steatosis (HP:0001414)2.40115969
33Prolonged neonatal jaundice (HP:0006579)2.40075077
34Long toe (HP:0010511)2.38265424
35Increased muscle lipid content (HP:0009058)2.37554878
36Striae distensae (HP:0001065)2.36955141
37Mitochondrial inheritance (HP:0001427)2.36050573
38Hepatocellular necrosis (HP:0001404)2.34225475
39Vertebral compression fractures (HP:0002953)2.33933262
40Hyperammonemia (HP:0001987)2.31451962
41Acute encephalopathy (HP:0006846)2.31448888
42Abnormality of fatty-acid metabolism (HP:0004359)2.30281982
43Hypokinesia (HP:0002375)2.29740485
44Increased intramyocellular lipid droplets (HP:0012240)2.29248756
45Recurrent bacterial skin infections (HP:0005406)2.26347576
46Abnormality of the distal phalanges of the toes (HP:0010182)2.25658862
47Hypoalphalipoproteinemia (HP:0003233)2.23651525
48Neuroendocrine neoplasm (HP:0100634)2.22128521
49Dilatation of the ascending aorta (HP:0005111)2.22097109
50Global brain atrophy (HP:0002283)2.21099527
51Hypercortisolism (HP:0001578)2.18295569
52Hepatic necrosis (HP:0002605)2.17549593
53Recurrent abscess formation (HP:0002722)2.17197089
54Hyperthyroidism (HP:0000836)2.16913006
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16815816
56Cervical subluxation (HP:0003308)2.15970826
57Mucopolysacchariduria (HP:0008155)2.15553097
58Urinary glycosaminoglycan excretion (HP:0003541)2.15553097
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13917196
60Shallow orbits (HP:0000586)2.13766137
61Increased CSF lactate (HP:0002490)2.11233367
62Back pain (HP:0003418)2.11181538
63Oligomenorrhea (HP:0000876)2.08773125
64Upper motor neuron abnormality (HP:0002127)2.07690157
65Abnormality of the Achilles tendon (HP:0005109)2.06818059
66Trismus (HP:0000211)2.06532843
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05731632
68Abnormal protein N-linked glycosylation (HP:0012347)2.05731632
69Abnormal protein glycosylation (HP:0012346)2.05731632
70Abnormal glycosylation (HP:0012345)2.05731632
71Onycholysis (HP:0001806)2.05211224
72Exercise intolerance (HP:0003546)2.04762130
73Chronic obstructive pulmonary disease (HP:0006510)2.04286095
74Obstructive lung disease (HP:0006536)2.04286095
75Complement deficiency (HP:0004431)2.04275836
76Peritonitis (HP:0002586)2.04126572
77Generalized amyotrophy (HP:0003700)2.03664888
78Systemic lupus erythematosus (HP:0002725)2.02696182
79Broad metatarsal (HP:0001783)2.01854322
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.01583325
81Loss of speech (HP:0002371)2.01148181
82Myokymia (HP:0002411)1.99837395
83Mitral stenosis (HP:0001718)1.99605067
84Abnormality of the nasal mucosa (HP:0000433)1.99250447
85Hyperlipoproteinemia (HP:0010980)1.98452678
86Lactic acidosis (HP:0003128)1.98067538
87Progressive macrocephaly (HP:0004481)1.96289215
88Aneurysm (HP:0002617)1.95989164
89Ankle contracture (HP:0006466)1.95954886
90Tetraplegia (HP:0002445)1.95902874
91Abnormality of proline metabolism (HP:0010907)1.95155944
92Hydroxyprolinuria (HP:0003080)1.95155944
93Athetosis (HP:0002305)1.94242287
94Achilles tendon contracture (HP:0001771)1.93840106
95Skin nodule (HP:0200036)1.93708505
96Abnormality of polysaccharide metabolism (HP:0011012)1.93547077
97Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93547077
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93547077
99Aortic aneurysm (HP:0004942)1.92393491
100Cerebral edema (HP:0002181)1.92294981
101Increased serum pyruvate (HP:0003542)1.91975152
102Fasciculations (HP:0002380)1.91886999
103Abnormal gallbladder physiology (HP:0012438)1.91419019
104Cholecystitis (HP:0001082)1.91419019
105Abnormality of purine metabolism (HP:0004352)1.90596553
106Supranuclear gaze palsy (HP:0000605)1.90179790
107Neonatal onset (HP:0003623)1.89233464
108Testicular atrophy (HP:0000029)1.89127830
109Hyperglycinuria (HP:0003108)1.89057013
110Abnormality of glycolysis (HP:0004366)1.88854942
111Aplastic anemia (HP:0001915)1.88609619
112Myoglobinuria (HP:0002913)1.88199865
113Entropion (HP:0000621)1.87887038
114Increased serum lactate (HP:0002151)1.87695206
115Polycythemia (HP:0001901)1.87558032
116Purpura (HP:0000979)1.86671302
117Nasal polyposis (HP:0100582)1.86193500
118Abnormality of the tricuspid valve (HP:0001702)1.85189999
119Emotional lability (HP:0000712)1.84183639
120Bladder diverticulum (HP:0000015)1.83576791
121Aortic dissection (HP:0002647)1.82604825
122Conjunctival hamartoma (HP:0100780)1.82493264
123Ventricular fibrillation (HP:0001663)1.82106541
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81903757
125Orthostatic hypotension (HP:0001278)1.81641060
126Increased serum ferritin (HP:0003281)1.81258174
127Cholelithiasis (HP:0001081)1.80907076
128Seborrheic dermatitis (HP:0001051)1.80472198
129Abnormal trabecular bone morphology (HP:0100671)1.79051644
130Nonimmune hydrops fetalis (HP:0001790)1.78916274
131Growth hormone excess (HP:0000845)1.78909911
132Personality changes (HP:0000751)1.78682366
133Short nail (HP:0001799)1.78614873
134Sensorimotor neuropathy (HP:0007141)1.78556257
135Abnormal cartilage morphology (HP:0002763)1.78430538
136Spastic paraparesis (HP:0002313)1.78096886
137Death in infancy (HP:0001522)1.77639973
138Reduced subcutaneous adipose tissue (HP:0003758)1.77328977
139Asymmetric septal hypertrophy (HP:0001670)1.77134524
140Visual hallucinations (HP:0002367)1.76634395
141Abnormality of liposaccharide metabolism (HP:0010968)1.76552616
142Abnormality of glycosphingolipid metabolism (HP:0004343)1.76552616
143Abnormality of glycolipid metabolism (HP:0010969)1.76552616
144Multiple enchondromatosis (HP:0005701)1.76480072
145Respiratory failure (HP:0002878)1.76356421
146Torticollis (HP:0000473)1.75549517
147Delusions (HP:0000746)1.74783865
148Abnormality of the lower motor neuron (HP:0002366)1.74639584
149Nail dystrophy (HP:0008404)1.74408924
150Eczematoid dermatitis (HP:0000976)1.73938848
151Rhabdomyolysis (HP:0003201)1.71834035
152Abnormality of the anterior horn cell (HP:0006802)1.71653862
153Degeneration of anterior horn cells (HP:0002398)1.71653862
154Truncus arteriosus (HP:0001660)1.71572996
155Cerebral hypomyelination (HP:0006808)1.71464423
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71424770
157Vacuolated lymphocytes (HP:0001922)1.71241985
158Difficulty climbing stairs (HP:0003551)1.70622438
159Late onset (HP:0003584)1.70120845
160Neoplasm of head and neck (HP:0012288)1.69581586
161Esophageal neoplasm (HP:0100751)1.69581586
162Abnormality of complement system (HP:0005339)1.69359059
163Enlarged penis (HP:0000040)1.69327456
164Abnormality of the intrinsic pathway (HP:0010989)1.68427094
165Hypolipoproteinemia (HP:0010981)1.68394177
166Abnormality of monocarboxylic acid metabolism (HP:0010996)1.67575817
167Abnormality of glycine metabolism (HP:0010895)1.67369671
168Abnormality of serine family amino acid metabolism (HP:0010894)1.67369671
169Axonal loss (HP:0003447)1.65500529
170Palpitations (HP:0001962)1.65119581
171Craniofacial dystonia (HP:0012179)1.64490880
172Biconcave vertebral bodies (HP:0004586)1.64131449
173Abnormality of the common coagulation pathway (HP:0010990)1.64092919
174Spastic diplegia (HP:0001264)1.64063163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.22030753
2ERN13.65357549
3PKN23.20215596
4IRAK32.98365747
5NEK12.62642524
6TESK22.55016811
7TESK12.34312234
8BCKDK2.20629679
9MAP3K132.17562649
10STK162.10400626
11LRRK22.06832516
12SCYL21.98532803
13EEF2K1.93946631
14SIK11.89440717
15CAMKK21.83960604
16RIPK11.79766971
17MAP3K91.76906261
18PRKD31.75623889
19KSR21.73930168
20CAMKK11.70650681
21VRK21.65354677
22TTN1.64271220
23ARAF1.62671554
24PTK61.60747745
25TAOK21.59219261
26LIMK11.57413413
27LMTK21.51770467
28EPHA21.46273944
29PDK21.44633020
30MAPKAPK31.41622712
31ABL21.40448794
32PIM21.38716950
33MAP3K141.34550160
34TAOK11.32170871
35PHKG21.29746795
36PHKG11.29746795
37LATS21.25581582
38TBK11.22734546
39PAK41.20787506
40BRAF1.20470628
41ILK1.19390773
42PDGFRA1.18449923
43DAPK31.17370549
44PAK61.16230740
45MOS1.15663615
46DDR21.13889308
47MAP2K11.09434265
48PAK31.08870761
49TXK1.06134842
50FGFR41.06086982
51RPS6KA41.05219010
52SRPK11.03395971
53PBK1.03190681
54PTK20.99137408
55PRKCH0.98906669
56RET0.96967280
57PRPF4B0.95557662
58PDK30.94410621
59PDK40.94410621
60DAPK20.94397063
61NME20.91767732
62MAP2K70.91381874
63KDR0.90829152
64MAP3K100.90739222
65AURKA0.88855952
66MINK10.88791124
67MAP3K110.87635154
68MAP3K20.86679221
69IKBKE0.86574757
70MAP3K80.84004343
71JAK30.82849179
72MAP3K120.80139243
73ALK0.79589489
74MARK10.78932605
75NTRK10.78586109
76IKBKB0.77881412
77FLT30.77529731
78MAP3K30.76293581
79MYLK0.75054152
80BMX0.73767828
81TLK10.73474725
82BUB10.73294098
83CSNK1G30.72743498
84CDK140.71244036
85IRAK40.70960116
86CAMK1D0.69323424
87CDK190.69116267
88DAPK10.67626460
89KIT0.66940930
90RPS6KB20.66572699
91BLK0.65261820
92FER0.63110981
93PAK20.62063590
94EIF2AK10.60363337
95DYRK1B0.59745211
96MST1R0.59095958
97MAP4K10.58701304
98CDK150.57464891
99JAK20.57184720
100PDPK10.57184588
101STK380.56800863
102EPHB10.54923751
103TAOK30.54799815
104TYK20.54315941
105CDK180.54163129
106GRK70.53963198
107PRKD10.53729891
108EPHA30.52504817
109FES0.51384831
110MAP3K50.51097904
111MAP3K10.50705405
112CDK11A0.50247959
113CSNK1A1L0.49942660
114NEK90.49922336
115MAP4K20.49831974
116RIPK40.49333268
117SMG10.48703918
118KSR10.48302762
119MAPK110.47444069
120WNK30.46814757
121GRK60.44765760
122MAP2K40.44694757
123STK100.44425480
124CDK40.43464313
125FGFR10.43454534
126PRKCZ0.42970726
127EPHB20.42670451
128MTOR0.41972319
129PDK10.40245338
130CAMK2G0.39856918
131CSK0.39374571
132PAK10.39296965
133BMPR20.39244383
134JAK10.39132792
135DYRK30.38901429
136IRAK20.38584650
137MAP2K30.38459447
138CSF1R0.38430467
139ZAP700.37967194
140ACVR1B0.37593084
141RAF10.36652884
142FGR0.35046531
143PRKCG0.33996620
144RPS6KA50.33874076
145TGFBR20.33833914
146AKT20.33578621
147PRKAA10.32967965
148SRC0.32645998
149PRKG20.29944872
150CSNK1G10.29288386
151MATK0.27057900
152MAPKAPK20.27040232
153CLK10.25406785

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.03075477
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51415557
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.46199420
4Nitrogen metabolism_Homo sapiens_hsa009103.22768606
5Oxidative phosphorylation_Homo sapiens_hsa001902.59232986
6Ribosome_Homo sapiens_hsa030102.39458147
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30693672
8Carbon metabolism_Homo sapiens_hsa012002.28517639
9Fatty acid elongation_Homo sapiens_hsa000622.23833191
10Fatty acid degradation_Homo sapiens_hsa000712.15949527
11Arginine biosynthesis_Homo sapiens_hsa002202.07661494
12Parkinsons disease_Homo sapiens_hsa050122.04342848
13Synaptic vesicle cycle_Homo sapiens_hsa047211.97838485
14Pentose phosphate pathway_Homo sapiens_hsa000301.96963404
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96281920
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94815489
17Biosynthesis of amino acids_Homo sapiens_hsa012301.93048075
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.83562455
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82186974
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76796437
21Propanoate metabolism_Homo sapiens_hsa006401.76627499
22Lysosome_Homo sapiens_hsa041421.76252262
23Pyruvate metabolism_Homo sapiens_hsa006201.74266361
24Pyrimidine metabolism_Homo sapiens_hsa002401.74059272
25RNA polymerase_Homo sapiens_hsa030201.70779099
26Fatty acid metabolism_Homo sapiens_hsa012121.67553285
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62283788
28DNA replication_Homo sapiens_hsa030301.59818153
29Butanoate metabolism_Homo sapiens_hsa006501.57099337
30Fructose and mannose metabolism_Homo sapiens_hsa000511.54810714
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52113267
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52003948
33PPAR signaling pathway_Homo sapiens_hsa033201.49206316
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43752828
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43558790
36Caffeine metabolism_Homo sapiens_hsa002321.42491628
37Selenocompound metabolism_Homo sapiens_hsa004501.41816116
38Tryptophan metabolism_Homo sapiens_hsa003801.39237610
39Rheumatoid arthritis_Homo sapiens_hsa053231.36657687
40Vibrio cholerae infection_Homo sapiens_hsa051101.31219554
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30410153
42Alzheimers disease_Homo sapiens_hsa050101.24512381
43Huntingtons disease_Homo sapiens_hsa050161.21758488
44Base excision repair_Homo sapiens_hsa034101.16937050
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15130783
46Sulfur relay system_Homo sapiens_hsa041221.13422533
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13042210
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12256310
49Bile secretion_Homo sapiens_hsa049761.12043150
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11333797
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10879140
52Collecting duct acid secretion_Homo sapiens_hsa049661.08809854
53Glutathione metabolism_Homo sapiens_hsa004801.08591759
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06776242
55Folate biosynthesis_Homo sapiens_hsa007901.06761689
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04513230
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03864099
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.03516592
59Spliceosome_Homo sapiens_hsa030401.02754854
60Sulfur metabolism_Homo sapiens_hsa009201.01915824
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00239572
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.99550859
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97296380
64Peroxisome_Homo sapiens_hsa041460.95742063
65Antigen processing and presentation_Homo sapiens_hsa046120.91711548
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91570518
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90548976
68Sphingolipid metabolism_Homo sapiens_hsa006000.87830506
69Complement and coagulation cascades_Homo sapiens_hsa046100.86915357
70Osteoclast differentiation_Homo sapiens_hsa043800.86563800
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85484958
72Apoptosis_Homo sapiens_hsa042100.83312599
73Prion diseases_Homo sapiens_hsa050200.82295954
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80211713
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.78003332
76Epstein-Barr virus infection_Homo sapiens_hsa051690.77676372
77Malaria_Homo sapiens_hsa051440.77609769
78Galactose metabolism_Homo sapiens_hsa000520.77010764
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.76774292
80Insulin signaling pathway_Homo sapiens_hsa049100.74732594
81Endocytosis_Homo sapiens_hsa041440.72810614
82mTOR signaling pathway_Homo sapiens_hsa041500.71603249
83Pertussis_Homo sapiens_hsa051330.71422292
84Fat digestion and absorption_Homo sapiens_hsa049750.69438009
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68750722
86Herpes simplex infection_Homo sapiens_hsa051680.66473930
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65682736
88Insulin resistance_Homo sapiens_hsa049310.63553366
89beta-Alanine metabolism_Homo sapiens_hsa004100.63160211
90Metabolic pathways_Homo sapiens_hsa011000.61097518
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60254220
92Primary immunodeficiency_Homo sapiens_hsa053400.60169751
93Phagosome_Homo sapiens_hsa041450.60075517
94Purine metabolism_Homo sapiens_hsa002300.59737123
95Leishmaniasis_Homo sapiens_hsa051400.59651310
96Nucleotide excision repair_Homo sapiens_hsa034200.59440205
97Hepatitis C_Homo sapiens_hsa051600.57786576
98Starch and sucrose metabolism_Homo sapiens_hsa005000.57528447
99Staphylococcus aureus infection_Homo sapiens_hsa051500.56899323
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.56861000
101Acute myeloid leukemia_Homo sapiens_hsa052210.56585882
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56386382
103Mismatch repair_Homo sapiens_hsa034300.53980985
104Bladder cancer_Homo sapiens_hsa052190.52649679
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52639482
106Glycerolipid metabolism_Homo sapiens_hsa005610.52290362
107N-Glycan biosynthesis_Homo sapiens_hsa005100.51872963
108Proteasome_Homo sapiens_hsa030500.51066844
109Glucagon signaling pathway_Homo sapiens_hsa049220.51017932
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50270437
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.49766596
112Phenylalanine metabolism_Homo sapiens_hsa003600.49241088
113Shigellosis_Homo sapiens_hsa051310.48770856
114AMPK signaling pathway_Homo sapiens_hsa041520.47777329
115Regulation of autophagy_Homo sapiens_hsa041400.47727943
116Proteoglycans in cancer_Homo sapiens_hsa052050.47132731
117Steroid biosynthesis_Homo sapiens_hsa001000.46995671
118Legionellosis_Homo sapiens_hsa051340.46948173
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.46663870
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46530293
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45942295
122TNF signaling pathway_Homo sapiens_hsa046680.45901114
123Measles_Homo sapiens_hsa051620.44370585
124Type II diabetes mellitus_Homo sapiens_hsa049300.44113582
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.43718339
126Pancreatic cancer_Homo sapiens_hsa052120.43053527
127Glioma_Homo sapiens_hsa052140.41417469
128Tuberculosis_Homo sapiens_hsa051520.41115908
129Hematopoietic cell lineage_Homo sapiens_hsa046400.39652684
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39035211
131Protein export_Homo sapiens_hsa030600.37605535
132Chemical carcinogenesis_Homo sapiens_hsa052040.36907130
133Viral myocarditis_Homo sapiens_hsa054160.36821908
134Thyroid hormone synthesis_Homo sapiens_hsa049180.36782406
135Viral carcinogenesis_Homo sapiens_hsa052030.36763033
136VEGF signaling pathway_Homo sapiens_hsa043700.36274193
137Tyrosine metabolism_Homo sapiens_hsa003500.36141686
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36119606
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35408029
140Other glycan degradation_Homo sapiens_hsa005110.34859984
141Amoebiasis_Homo sapiens_hsa051460.34586759
142HIF-1 signaling pathway_Homo sapiens_hsa040660.34246699
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33247260
144Insulin secretion_Homo sapiens_hsa049110.32586659
145GABAergic synapse_Homo sapiens_hsa047270.32300646
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31613777
147Chronic myeloid leukemia_Homo sapiens_hsa052200.31046152
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29701603
149Salmonella infection_Homo sapiens_hsa051320.27309136
150Gastric acid secretion_Homo sapiens_hsa049710.26923128
151Focal adhesion_Homo sapiens_hsa045100.26574308
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26415374
153Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25211595
154Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25106318

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