TRAPPC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.65441976
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.26509244
3chaperone-mediated protein transport (GO:0072321)5.21660005
4protein neddylation (GO:0045116)4.96331534
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.92440451
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85618234
7ATP synthesis coupled proton transport (GO:0015986)4.85618234
8cullin deneddylation (GO:0010388)4.82002120
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.76306802
10regulation of cellular amino acid metabolic process (GO:0006521)4.55926086
11negative regulation of ligase activity (GO:0051352)4.54872148
12negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.54872148
13protein deneddylation (GO:0000338)4.50428963
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.45332364
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.42639959
16behavioral response to nicotine (GO:0035095)4.37604938
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.31479456
18signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.31371356
19intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.31371356
20termination of RNA polymerase III transcription (GO:0006386)4.30706301
21transcription elongation from RNA polymerase III promoter (GO:0006385)4.30706301
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.29265366
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.28741116
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.28741116
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.28741116
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.14193194
27signal transduction involved in DNA integrity checkpoint (GO:0072401)4.11734185
28signal transduction involved in DNA damage checkpoint (GO:0072422)4.11734185
29signal transduction involved in cell cycle checkpoint (GO:0072395)4.11203783
30protein complex biogenesis (GO:0070271)4.09006054
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.08353527
327-methylguanosine RNA capping (GO:0009452)4.06145836
33RNA capping (GO:0036260)4.06145836
347-methylguanosine mRNA capping (GO:0006370)4.05612366
35antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.05278157
36respiratory electron transport chain (GO:0022904)4.01750867
37electron transport chain (GO:0022900)3.93341191
38ribosomal small subunit assembly (GO:0000028)3.93286999
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90639070
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.90639070
41NADH dehydrogenase complex assembly (GO:0010257)3.90639070
42DNA deamination (GO:0045006)3.90285427
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.79315885
44mitochondrial respiratory chain complex assembly (GO:0033108)3.69591142
45protein targeting to mitochondrion (GO:0006626)3.67639876
46water-soluble vitamin biosynthetic process (GO:0042364)3.66242998
47positive regulation of ligase activity (GO:0051351)3.65475000
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.64242686
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.64242686
50guanosine-containing compound biosynthetic process (GO:1901070)3.62705498
51establishment of protein localization to mitochondrion (GO:0072655)3.60081696
52ribosomal small subunit biogenesis (GO:0042274)3.59425862
53regulation of mitochondrial translation (GO:0070129)3.57899534
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.56898323
55GTP biosynthetic process (GO:0006183)3.47170530
56regulation of cellular amine metabolic process (GO:0033238)3.47116156
57respiratory chain complex IV assembly (GO:0008535)3.46406877
58peptidyl-histidine modification (GO:0018202)3.37899214
59pyrimidine nucleobase catabolic process (GO:0006208)3.35856443
60DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.35836506
61regulation of ubiquitin-protein transferase activity (GO:0051438)3.33622124
62hydrogen ion transmembrane transport (GO:1902600)3.33352044
63protein localization to mitochondrion (GO:0070585)3.31776294
64cytochrome complex assembly (GO:0017004)3.31664344
65antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.30027152
66positive regulation of cell cycle arrest (GO:0071158)3.27513481
67regulation of ligase activity (GO:0051340)3.24025795
68maturation of SSU-rRNA (GO:0030490)3.20075783
69viral transcription (GO:0019083)3.17229509
70purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16862302
71platelet dense granule organization (GO:0060155)3.16587937
72ATP biosynthetic process (GO:0006754)3.15624546
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14250497
74proton transport (GO:0015992)3.14033125
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14027333
76negative regulation of telomere maintenance (GO:0032205)3.12795709
77intracellular protein transmembrane import (GO:0044743)3.11954259
78translation (GO:0006412)3.11343758
79de novo posttranslational protein folding (GO:0051084)3.11187110
80tRNA processing (GO:0008033)3.10565256
81cellular component biogenesis (GO:0044085)3.10507939
82de novo protein folding (GO:0006458)3.08802660
83positive regulation of mitochondrial fission (GO:0090141)3.07445572
84cotranslational protein targeting to membrane (GO:0006613)3.06475369
85hydrogen transport (GO:0006818)3.05943588
86ribosomal large subunit biogenesis (GO:0042273)3.05838704
872-deoxyribonucleotide biosynthetic process (GO:0009265)3.04689073
88deoxyribose phosphate biosynthetic process (GO:0046385)3.04689073
89SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04187656
90epithelial cilium movement (GO:0003351)3.03422995
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03282807
92translational termination (GO:0006415)3.02450456
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99307330
94deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.98958766
95protein targeting to ER (GO:0045047)2.97478770
96iron-sulfur cluster assembly (GO:0016226)2.97177476
97metallo-sulfur cluster assembly (GO:0031163)2.97177476
98rRNA modification (GO:0000154)2.95079408
99negative regulation of protein ubiquitination (GO:0031397)2.94756530
100ribonucleoprotein complex biogenesis (GO:0022613)2.94650354
101pseudouridine synthesis (GO:0001522)2.94475814
102UTP biosynthetic process (GO:0006228)2.93411794
103negative regulation of cell cycle G1/S phase transition (GO:1902807)2.92768481
104negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.92768481
105protein localization to endoplasmic reticulum (GO:0070972)2.91162102
106transcription elongation from RNA polymerase I promoter (GO:0006362)2.88371540
107nucleobase-containing small molecule interconversion (GO:0015949)2.83964313
108signal transduction in response to DNA damage (GO:0042770)2.83497277
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83220113
110deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.82421522
111nucleobase catabolic process (GO:0046113)2.82225397
112protein-cofactor linkage (GO:0018065)2.82114773
113DNA damage response, detection of DNA damage (GO:0042769)2.81696904
114transcription from RNA polymerase I promoter (GO:0006360)2.80286500
115GMP metabolic process (GO:0046037)2.79549938
116establishment of protein localization to endoplasmic reticulum (GO:0072599)2.79046700
117response to pheromone (GO:0019236)2.77085430
118spliceosomal snRNP assembly (GO:0000387)2.74746280
119ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74134390
120regulation of cilium movement (GO:0003352)2.73491568
121positive regulation of protein homodimerization activity (GO:0090073)2.72368005
122ubiquinone metabolic process (GO:0006743)2.67343051
123tRNA metabolic process (GO:0006399)2.67126302
124mannosylation (GO:0097502)2.66053665
125sequestering of actin monomers (GO:0042989)2.65973490
126preassembly of GPI anchor in ER membrane (GO:0016254)2.65210247
127substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.61270348
128substrate-independent telencephalic tangential migration (GO:0021826)2.61270348
129ubiquinone biosynthetic process (GO:0006744)2.60596801
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60093611
131protein polyglutamylation (GO:0018095)2.56618034
132retinal ganglion cell axon guidance (GO:0031290)2.53417650
133pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.52174722
134cellular ketone body metabolic process (GO:0046950)2.51471433
135inner mitochondrial membrane organization (GO:0007007)2.51230263
136rRNA methylation (GO:0031167)2.51098823
137negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.50440709
138nucleoside triphosphate biosynthetic process (GO:0009142)2.48499575
139negative regulation of DNA-dependent DNA replication (GO:2000104)2.46482395
140tRNA modification (GO:0006400)2.44703635
141base-excision repair, AP site formation (GO:0006285)2.44293923
142cilium movement (GO:0003341)2.43250045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.06578079
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.73667121
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.45933447
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.27075238
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.08040991
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.74827399
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.61643171
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.58309213
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49378397
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.45085029
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.42546568
12ZNF274_21170338_ChIP-Seq_K562_Hela3.39154624
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.38021471
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.13108605
15* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98313824
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.90766285
17EZH2_22144423_ChIP-Seq_EOC_Human2.86412701
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76466023
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.69163102
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.68127287
21* VDR_23849224_ChIP-Seq_CD4+_Human2.63629880
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.62711620
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56078316
24YY1_21170310_ChIP-Seq_MESCs_Mouse2.47728257
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31309727
26DCP1A_22483619_ChIP-Seq_HELA_Human2.26942106
27ELK1_19687146_ChIP-ChIP_HELA_Human2.24971568
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22819495
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20483493
30XRN2_22483619_ChIP-Seq_HELA_Human2.10451424
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.02445835
32GABP_19822575_ChIP-Seq_HepG2_Human2.01761134
33FOXP3_21729870_ChIP-Seq_TREG_Human1.98113989
34* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94207595
35TTF2_22483619_ChIP-Seq_HELA_Human1.92519323
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92362160
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70379358
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67066093
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.66991770
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66578941
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66461507
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.66360790
43EWS_26573619_Chip-Seq_HEK293_Human1.63969049
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61999809
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60916170
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60277192
47TP53_22573176_ChIP-Seq_HFKS_Human1.60152066
48FUS_26573619_Chip-Seq_HEK293_Human1.58668336
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51129493
50* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48969260
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47457725
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43844079
53REST_21632747_ChIP-Seq_MESCs_Mouse1.38693303
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38007370
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37188383
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37133890
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34807704
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34659686
59P300_19829295_ChIP-Seq_ESCs_Human1.34061504
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.33957335
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33247367
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.30529369
63* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26943799
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25248958
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24358895
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23645742
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.23297706
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22186049
69MYC_18940864_ChIP-ChIP_HL60_Human1.21196208
70GBX2_23144817_ChIP-Seq_PC3_Human1.21084315
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20784002
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20121587
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18833965
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17958882
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.17085954
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17085954
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16660551
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16579169
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14732327
80* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14588811
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.13440289
82TAF15_26573619_Chip-Seq_HEK293_Human1.13005654
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12356312
84NCOR_22424771_ChIP-Seq_293T_Human1.10846141
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10593378
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.09213424
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08110076
88IRF1_19129219_ChIP-ChIP_H3396_Human1.07589466
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06154968
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05979170
91* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05898534
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05436251
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04707114
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04535631
95ER_23166858_ChIP-Seq_MCF-7_Human1.04018333
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03596512
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02512228
98VDR_22108803_ChIP-Seq_LS180_Human1.02267773
99* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01234499
100* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99497748
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99067845
102NANOG_16153702_ChIP-ChIP_HESCs_Human0.96818780
103IGF1R_20145208_ChIP-Seq_DFB_Human0.96206673
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96091809
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96057253
106GATA3_21878914_ChIP-Seq_MCF-7_Human0.95598916
107AR_25329375_ChIP-Seq_VCAP_Human0.94002748
108SOX2_19829295_ChIP-Seq_ESCs_Human0.93013447
109NANOG_19829295_ChIP-Seq_ESCs_Human0.93013447
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92932870
111CBP_20019798_ChIP-Seq_JUKART_Human0.92932870
112AR_20517297_ChIP-Seq_VCAP_Human0.91417227
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90874415
114* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90846186
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90833503
116E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90794462
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.90275509
118BCAT_22108803_ChIP-Seq_LS180_Human0.89377568
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89242045
120HTT_18923047_ChIP-ChIP_STHdh_Human0.88505092
121YY1_22570637_ChIP-Seq_MALME-3M_Human0.85702328
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85555298
123NANOG_20526341_ChIP-Seq_ESCs_Human0.85514047
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85077719
125* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84522447
126HOXB7_26014856_ChIP-Seq_BT474_Human0.83750013
127CIITA_25753668_ChIP-Seq_RAJI_Human0.83448587
128TCF4_22108803_ChIP-Seq_LS180_Human0.83372221
129NOTCH1_21737748_ChIP-Seq_TLL_Human0.83175484
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81420328
131SPI1_23547873_ChIP-Seq_NB4_Human0.76811160
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76735514
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75051732
134RNF2_27304074_Chip-Seq_NSC_Mouse0.72622621
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71133341
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71078909
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70857647
138PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70764373
139* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.68352596
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67212189
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66278716
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.64313429
143ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.64312071
144REST_19997604_ChIP-ChIP_NEURONS_Mouse0.64241005
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.63769411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.39732746
2MP0003787_abnormal_imprinting3.04083043
3MP0006276_abnormal_autonomic_nervous2.95835300
4MP0003880_abnormal_central_pattern2.92560669
5MP0001905_abnormal_dopamine_level2.90432164
6MP0008260_abnormal_autophagy2.89173693
7MP0001986_abnormal_taste_sensitivity2.77609007
8MP0009379_abnormal_foot_pigmentation2.44123645
9MP0003693_abnormal_embryo_hatching2.42035067
10MP0002736_abnormal_nociception_after2.41260153
11MP0002735_abnormal_chemical_nociception2.38618180
12MP0002837_dystrophic_cardiac_calcinosis2.23897126
13MP0001968_abnormal_touch/_nociception2.20443859
14MP0001188_hyperpigmentation2.04260080
15MP0003121_genomic_imprinting2.03400097
16MP0003011_delayed_dark_adaptation2.02579654
17MP0002734_abnormal_mechanical_nocicepti1.98878327
18MP0002653_abnormal_ependyma_morphology1.91862687
19MP0000372_irregular_coat_pigmentation1.85439192
20MP0006035_abnormal_mitochondrial_morpho1.81385990
21MP0004133_heterotaxia1.81340105
22MP0005551_abnormal_eye_electrophysiolog1.79648561
23MP0003123_paternal_imprinting1.77706063
24MP0003315_abnormal_perineum_morphology1.74513649
25MP0004957_abnormal_blastocyst_morpholog1.72847721
26MP0002751_abnormal_autonomic_nervous1.72683179
27MP0009333_abnormal_splenocyte_physiolog1.72185261
28MP0003718_maternal_effect1.68646401
29MP0002876_abnormal_thyroid_physiology1.68021802
30MP0001984_abnormal_olfaction1.66918421
31MP0008932_abnormal_embryonic_tissue1.65628532
32MP0003186_abnormal_redox_activity1.65334780
33MP0008789_abnormal_olfactory_epithelium1.62451249
34MP0002163_abnormal_gland_morphology1.62204232
35MP0006292_abnormal_olfactory_placode1.58883533
36MP0001970_abnormal_pain_threshold1.58245406
37MP0004270_analgesia1.57721277
38MP0009785_altered_susceptibility_to1.57302959
39MP0003183_abnormal_peptide_metabolism1.57177432
40MP0002132_abnormal_respiratory_system1.56169886
41MP0002733_abnormal_thermal_nociception1.55604577
42MP0008058_abnormal_DNA_repair1.54726025
43MP0008872_abnormal_physiological_respon1.53764005
44MP0004147_increased_porphyrin_level1.51412528
45MP0006036_abnormal_mitochondrial_physio1.50993645
46MP0004142_abnormal_muscle_tone1.48398079
47MP0002148_abnormal_hypersensitivity_rea1.45560948
48MP0002638_abnormal_pupillary_reflex1.44612905
49MP0009697_abnormal_copulation1.44456162
50MP0008875_abnormal_xenobiotic_pharmacok1.43629166
51MP0005084_abnormal_gallbladder_morpholo1.42670940
52MP0002184_abnormal_innervation1.39449755
53MP0002272_abnormal_nervous_system1.36294817
54MP0003195_calcinosis1.35693910
55MP0004885_abnormal_endolymph1.35683842
56MP0001835_abnormal_antigen_presentation1.35546400
57MP0005645_abnormal_hypothalamus_physiol1.35021247
58MP0002557_abnormal_social/conspecific_i1.33460228
59MP0001440_abnormal_grooming_behavior1.33054130
60MP0001542_abnormal_bone_strength1.31444597
61MP0003786_premature_aging1.29094693
62MP0005499_abnormal_olfactory_system1.28467386
63MP0005394_taste/olfaction_phenotype1.28467386
64MP0005253_abnormal_eye_physiology1.24898900
65MP0004782_abnormal_surfactant_physiolog1.22185033
66MP0005671_abnormal_response_to1.21645326
67MP0002064_seizures1.21490642
68MP0009046_muscle_twitch1.20764243
69MP0000015_abnormal_ear_pigmentation1.18239963
70MP0001919_abnormal_reproductive_system1.17616206
71MP0002277_abnormal_respiratory_mucosa1.16255447
72MP0001293_anophthalmia1.15985461
73MP0002909_abnormal_adrenal_gland1.13631672
74MP0009745_abnormal_behavioral_response1.13582438
75MP0003077_abnormal_cell_cycle1.13148162
76MP0002822_catalepsy1.12273206
77MP0010386_abnormal_urinary_bladder1.12253814
78MP0002102_abnormal_ear_morphology1.11016380
79MP0000778_abnormal_nervous_system1.09930190
80MP0005423_abnormal_somatic_nervous1.09385569
81MP0003436_decreased_susceptibility_to1.08558201
82MP0000427_abnormal_hair_cycle1.06633983
83MP0005195_abnormal_posterior_eye1.06283784
84MP0003136_yellow_coat_color1.05713746
85MP0008007_abnormal_cellular_replicative1.05506028
86MP0005000_abnormal_immune_tolerance1.05275215
87MP0008877_abnormal_DNA_methylation1.03219732
88MP0002210_abnormal_sex_determination1.02561012
89MP0002572_abnormal_emotion/affect_behav1.02375999
90MP0008995_early_reproductive_senescence1.01059322
91MP0000955_abnormal_spinal_cord1.00111868
92MP0005646_abnormal_pituitary_gland0.99200172
93MP0001727_abnormal_embryo_implantation0.98298128
94MP0002067_abnormal_sensory_capabilities0.98098092
95MP0003724_increased_susceptibility_to0.96460978
96MP0002882_abnormal_neuron_morphology0.93003395
97MP0005379_endocrine/exocrine_gland_phen0.91204360
98MP0004145_abnormal_muscle_electrophysio0.90198484
99MP0001486_abnormal_startle_reflex0.90182715
100MP0006082_CNS_inflammation0.90111558
101MP0002063_abnormal_learning/memory/cond0.90105938
102MP0005386_behavior/neurological_phenoty0.89958273
103MP0004924_abnormal_behavior0.89958273
104MP0003890_abnormal_embryonic-extraembry0.89779852
105MP0004742_abnormal_vestibular_system0.89776915
106MP0003646_muscle_fatigue0.88601362
107MP0000681_abnormal_thyroid_gland0.88302233
108MP0003635_abnormal_synaptic_transmissio0.88258562
109MP0002160_abnormal_reproductive_system0.88068698
110MP0002234_abnormal_pharynx_morphology0.87859512
111MP0005171_absent_coat_pigmentation0.87113673
112MP0005174_abnormal_tail_pigmentation0.86947755
113MP0002229_neurodegeneration0.86075293
114MP0005332_abnormal_amino_acid0.85079096
115MP0000358_abnormal_cell_content/0.84936226
116MP0001485_abnormal_pinna_reflex0.82784240
117MP0005025_abnormal_response_to0.81376707
118MP0003283_abnormal_digestive_organ0.80759412
119MP0004859_abnormal_synaptic_plasticity0.80708807
120MP0010094_abnormal_chromosome_stability0.80195445
121MP0003806_abnormal_nucleotide_metabolis0.79736602
122MP0002752_abnormal_somatic_nervous0.79522168
123MP0002332_abnormal_exercise_endurance0.78180316
124MP0002090_abnormal_vision0.77140450
125MP0002938_white_spotting0.77074308
126MP0002693_abnormal_pancreas_physiology0.76801740
127MP0001348_abnormal_lacrimal_gland0.75327812
128MP0005389_reproductive_system_phenotype0.75261917
129MP0001501_abnormal_sleep_pattern0.74499090
130MP0001963_abnormal_hearing_physiology0.74443329
131MP0003122_maternal_imprinting0.73854223
132MP0005075_abnormal_melanosome_morpholog0.73319000
133MP0000026_abnormal_inner_ear0.71723754
134MP0002095_abnormal_skin_pigmentation0.69034322
135MP0000631_abnormal_neuroendocrine_gland0.68630514
136MP0006072_abnormal_retinal_apoptosis0.68046580

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.99371649
2Abnormal mitochondria in muscle tissue (HP:0008316)5.33634169
3Mitochondrial inheritance (HP:0001427)5.00355409
4Progressive macrocephaly (HP:0004481)4.89505599
5Acute encephalopathy (HP:0006846)4.46888850
6Increased CSF lactate (HP:0002490)4.35538697
7Increased serum pyruvate (HP:0003542)4.29081752
8Abnormality of glycolysis (HP:0004366)4.29081752
9Hepatocellular necrosis (HP:0001404)4.22326956
103-Methylglutaconic aciduria (HP:0003535)3.82877691
11Molar tooth sign on MRI (HP:0002419)3.56153279
12Abnormality of midbrain morphology (HP:0002418)3.56153279
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.45770287
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.45770287
15Hepatic necrosis (HP:0002605)3.38571951
16Increased hepatocellular lipid droplets (HP:0006565)3.37906936
17Cerebral hypomyelination (HP:0006808)3.36302446
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.28763911
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.15081272
20Nephronophthisis (HP:0000090)3.07921586
21Neuroendocrine neoplasm (HP:0100634)3.05947976
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02736072
23Increased serum lactate (HP:0002151)3.01027702
24Renal Fanconi syndrome (HP:0001994)2.96680604
25Abnormal hair whorl (HP:0010721)2.95832458
26Hypothermia (HP:0002045)2.93764583
27Optic disc pallor (HP:0000543)2.91459817
28Abnormality of cells of the erythroid lineage (HP:0012130)2.91108899
29Respiratory failure (HP:0002878)2.90944431
30Leukodystrophy (HP:0002415)2.88502362
31Type II lissencephaly (HP:0007260)2.88321055
32Exercise intolerance (HP:0003546)2.84666591
33Lactic acidosis (HP:0003128)2.81525611
34Parakeratosis (HP:0001036)2.80015055
35Poor suck (HP:0002033)2.77486713
36Pheochromocytoma (HP:0002666)2.75604706
37Medial flaring of the eyebrow (HP:0010747)2.74399312
38Lipid accumulation in hepatocytes (HP:0006561)2.72157102
39Birth length less than 3rd percentile (HP:0003561)2.64882430
40Abnormal number of erythroid precursors (HP:0012131)2.61060058
41Cerebral edema (HP:0002181)2.61003228
42Exertional dyspnea (HP:0002875)2.60304297
43Type I transferrin isoform profile (HP:0003642)2.59275416
44Aplastic anemia (HP:0001915)2.57964812
45Congenital stationary night blindness (HP:0007642)2.49802689
46Methylmalonic acidemia (HP:0002912)2.47912914
47Respiratory difficulties (HP:0002880)2.46523222
48Congenital ichthyosiform erythroderma (HP:0007431)2.44892698
49Sclerocornea (HP:0000647)2.44820115
50Abnormality of the renal medulla (HP:0100957)2.43921108
51Reticulocytopenia (HP:0001896)2.39117480
52Type 2 muscle fiber atrophy (HP:0003554)2.32097137
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21737246
54Abnormal protein N-linked glycosylation (HP:0012347)2.21737246
55Abnormal protein glycosylation (HP:0012346)2.21737246
56Abnormal glycosylation (HP:0012345)2.21737246
57Increased intramyocellular lipid droplets (HP:0012240)2.20573737
58Congenital, generalized hypertrichosis (HP:0004540)2.19911144
59Glycosuria (HP:0003076)2.19750555
60Abnormality of urine glucose concentration (HP:0011016)2.19750555
61Muscle fiber atrophy (HP:0100295)2.18293886
62Abolished electroretinogram (ERG) (HP:0000550)2.17430121
63Gait imbalance (HP:0002141)2.17261635
64Microvesicular hepatic steatosis (HP:0001414)2.17210341
65Methylmalonic aciduria (HP:0012120)2.16851447
66Lethargy (HP:0001254)2.16776814
67Pendular nystagmus (HP:0012043)2.14089343
68Abnormality of the anterior horn cell (HP:0006802)2.14004974
69Degeneration of anterior horn cells (HP:0002398)2.14004974
70Nephrogenic diabetes insipidus (HP:0009806)2.13750803
71Rough bone trabeculation (HP:0100670)2.12410948
72Vaginal atresia (HP:0000148)2.09132915
73CNS hypomyelination (HP:0003429)2.08606189
74Cystic liver disease (HP:0006706)2.08336980
75Congenital primary aphakia (HP:0007707)2.08187222
76Genital tract atresia (HP:0001827)2.07393532
77Limb dystonia (HP:0002451)2.05691528
78Abnormality of the renal cortex (HP:0011035)2.04825766
79Colon cancer (HP:0003003)2.04489434
80Myokymia (HP:0002411)2.03627023
81Pallor (HP:0000980)2.02455204
82Autoamputation (HP:0001218)2.02033207
83Increased IgM level (HP:0003496)2.00544341
84Lissencephaly (HP:0001339)2.00151664
85Septo-optic dysplasia (HP:0100842)1.99341984
86Absent thumb (HP:0009777)1.99280115
87Abnormal biliary tract physiology (HP:0012439)1.98105475
88Bile duct proliferation (HP:0001408)1.98105475
89Adrenal hypoplasia (HP:0000835)1.97717133
90CNS demyelination (HP:0007305)1.97060651
91Emotional lability (HP:0000712)1.96357091
92Polyphagia (HP:0002591)1.96250586
93Pachygyria (HP:0001302)1.94996777
94Hyperglycinemia (HP:0002154)1.94413101
95Poor head control (HP:0002421)1.94320311
96Anencephaly (HP:0002323)1.92156869
97Macrocytic anemia (HP:0001972)1.90669486
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89763973
99Delusions (HP:0000746)1.89682786
100Breast hypoplasia (HP:0003187)1.89040748
101Failure to thrive in infancy (HP:0001531)1.88688283
102Hypoplasia of the pons (HP:0012110)1.88047058
103Irregular epiphyses (HP:0010582)1.87786568
104Aplasia/hypoplasia of the uterus (HP:0008684)1.86861440
105Abnormality of the pons (HP:0007361)1.85684935
106Abnormality of placental membranes (HP:0011409)1.85179756
107Amniotic constriction ring (HP:0009775)1.85179756
108Abnormal rod and cone electroretinograms (HP:0008323)1.84563685
109Abnormality of the labia minora (HP:0012880)1.84209683
110Hyperphosphaturia (HP:0003109)1.83920495
111Tubular atrophy (HP:0000092)1.81838316
112Male pseudohermaphroditism (HP:0000037)1.80630172
113Optic nerve hypoplasia (HP:0000609)1.79606770
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79454836
115Abnormality of renal resorption (HP:0011038)1.79228472
116Abnormal drinking behavior (HP:0030082)1.78963212
117Polydipsia (HP:0001959)1.78963212
118Tachypnea (HP:0002789)1.78639413
119Abnormal ciliary motility (HP:0012262)1.78244395
120Supernumerary spleens (HP:0009799)1.76637789
121Concave nail (HP:0001598)1.73793172
122Pancreatic fibrosis (HP:0100732)1.73728405
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.73578716
124Severe muscular hypotonia (HP:0006829)1.73278242
125Renal cortical cysts (HP:0000803)1.73195986
126Esotropia (HP:0000565)1.72489971
127Generalized aminoaciduria (HP:0002909)1.72292542
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72228305
129Poor coordination (HP:0002370)1.71649462
130Bone marrow hypocellularity (HP:0005528)1.71638366
131Oral leukoplakia (HP:0002745)1.70555589
132Abnormal pupillary function (HP:0007686)1.69489807
133X-linked dominant inheritance (HP:0001423)1.68588504
134Postnatal microcephaly (HP:0005484)1.66603394
135Pancytopenia (HP:0001876)1.65455556
136Prolonged neonatal jaundice (HP:0006579)1.64844379
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64177506
138Abnormality of alanine metabolism (HP:0010916)1.64177506
139Hyperalaninemia (HP:0003348)1.64177506
140Abnormal trabecular bone morphology (HP:0100671)1.63787556
141True hermaphroditism (HP:0010459)1.62783934
142Carpal bone hypoplasia (HP:0001498)1.62361207
143Retinal dysplasia (HP:0007973)1.61053853
144Pancreatic cysts (HP:0001737)1.60501415
145Oligomenorrhea (HP:0000876)1.59595616
146Increased muscle lipid content (HP:0009058)1.59276388
147Abnormal autonomic nervous system physiology (HP:0012332)1.59159079
148Atonic seizures (HP:0010819)1.58340747
149Neoplasm of the adrenal gland (HP:0100631)1.58027926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.94765449
2STK163.61269296
3MAP3K123.23045027
4VRK22.80162921
5WNK42.67116174
6NME22.64878720
7MAP3K42.46490041
8FRK2.35757732
9MAP4K22.34463652
10TSSK62.31697932
11MST42.31047792
12SIK32.23889885
13EIF2AK12.22194585
14PIM22.20750711
15DYRK22.14855746
16LIMK12.09166160
17GRK12.07127981
18ARAF2.06392416
19VRK12.03157091
20NUAK12.02415847
21CASK2.00630127
22TRIM282.00341699
23NME11.93958277
24MARK11.93849244
25BCR1.93029505
26CDK191.77663381
27TESK21.74231829
28BCKDK1.74037851
29EIF2AK31.63562936
30MUSK1.60635075
31WEE11.57507315
32ADRBK21.57048240
33PBK1.56328582
34SRPK11.49599682
35BRAF1.45233058
36BMPR1B1.44609175
37INSRR1.32660583
38MAP2K71.30015101
39PRPF4B1.29877059
40CDC71.25204912
41PLK41.22171003
42TESK11.22140246
43TXK1.20160296
44ACVR1B1.16845272
45TNIK1.16287794
46MAPK131.14317137
47CCNB11.14103953
48NTRK21.12419954
49TAOK31.12382779
50GRK71.07193000
51GRK51.04064430
52OXSR11.01898465
53MKNK11.01722535
54AKT31.01515676
55PHKG21.01013763
56PHKG11.01013763
57PAK31.00992382
58IRAK40.99984373
59CDK80.97050111
60IRAK10.94406642
61MYLK0.94405505
62PLK20.93664142
63CSNK1G30.93028318
64ERBB30.91792490
65TLK10.90569274
66MINK10.90128195
67NTRK30.85903043
68YES10.85181780
69PNCK0.81268786
70BRSK20.80260958
71EPHA30.79248720
72AURKA0.79072238
73DYRK30.78876328
74PLK30.77685203
75PIK3CA0.75662638
76MAPKAPK50.71461942
77DAPK10.70796615
78MAP3K110.70580351
79EPHB20.70268633
80STK390.68356510
81ADRBK10.68001991
82PDK20.67568292
83MATK0.66448844
84RPS6KA50.66073894
85ABL20.62537406
86CSNK1A1L0.62482948
87CLK10.60362119
88BRSK10.60018481
89CDK140.57397598
90BMPR20.57284115
91WNK30.56231811
92MAP2K60.56094982
93CDK180.55896870
94EPHB10.55640563
95CSNK2A10.55214120
96ATR0.53767858
97UHMK10.53441417
98CAMK2B0.52404732
99KDR0.51126325
100CAMKK20.50982509
101ZAK0.50327913
102EIF2AK20.49286723
103CSNK1A10.48602668
104MAP3K90.47614990
105CSNK1G20.47174219
106PRKACA0.46826111
107MKNK20.45614310
108PLK10.44835070
109TIE10.44631253
110PASK0.44523250
111CSNK1E0.44497471
112PRKCQ0.44041528
113CDK150.43425269
114MAP2K40.42363656
115CSNK1G10.41576845
116PRKCG0.41403485
117CDK11A0.41264306
118MAPKAPK30.41092907
119PAK10.40762119
120SYK0.40337188
121BLK0.39097980
122PINK10.39063260
123CSNK2A20.38804863
124DAPK20.38625969
125CAMK2D0.38305748
126EPHA40.38150354
127CHEK20.37690342
128PRKCE0.36637618
129CAMK10.36573393
130NLK0.36554169
131MAPK40.34871230
132CAMK2G0.34388941
133PRKCI0.32931271
134PRKCD0.30781549
135NEK10.29256345
136KIT0.26048492
137CAMK2A0.25378301
138LYN0.25156799

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.52612408
2Oxidative phosphorylation_Homo sapiens_hsa001904.25775333
3Ribosome_Homo sapiens_hsa030103.85189591
4RNA polymerase_Homo sapiens_hsa030203.74846909
5Parkinsons disease_Homo sapiens_hsa050123.65511781
6Huntingtons disease_Homo sapiens_hsa050162.71467986
7Protein export_Homo sapiens_hsa030602.67618411
8Alzheimers disease_Homo sapiens_hsa050102.46032659
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25476172
10Pyrimidine metabolism_Homo sapiens_hsa002402.14700355
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08639593
12Collecting duct acid secretion_Homo sapiens_hsa049662.08064608
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05376108
14Spliceosome_Homo sapiens_hsa030401.88700319
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82031774
16DNA replication_Homo sapiens_hsa030301.75668991
17Selenocompound metabolism_Homo sapiens_hsa004501.52703991
18Nucleotide excision repair_Homo sapiens_hsa034201.51730382
19Mismatch repair_Homo sapiens_hsa034301.51273942
20Vibrio cholerae infection_Homo sapiens_hsa051101.49109353
21Homologous recombination_Homo sapiens_hsa034401.48602503
22Butanoate metabolism_Homo sapiens_hsa006501.45279311
23Basal transcription factors_Homo sapiens_hsa030221.41322294
24Graft-versus-host disease_Homo sapiens_hsa053321.40919825
25Rheumatoid arthritis_Homo sapiens_hsa053231.39661041
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38793739
27Purine metabolism_Homo sapiens_hsa002301.35007139
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.34092717
29Synaptic vesicle cycle_Homo sapiens_hsa047211.31345549
30RNA transport_Homo sapiens_hsa030131.31300147
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30601669
32Allograft rejection_Homo sapiens_hsa053301.27888478
33Steroid biosynthesis_Homo sapiens_hsa001001.27823340
34Base excision repair_Homo sapiens_hsa034101.27151265
35Propanoate metabolism_Homo sapiens_hsa006401.23730645
36Linoleic acid metabolism_Homo sapiens_hsa005911.23687218
37Regulation of autophagy_Homo sapiens_hsa041401.17440020
38Peroxisome_Homo sapiens_hsa041461.16321484
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16021789
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15834694
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12533608
42Tryptophan metabolism_Homo sapiens_hsa003801.12239439
43Phagosome_Homo sapiens_hsa041451.11530841
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04812525
45RNA degradation_Homo sapiens_hsa030181.03071719
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02807642
47Nitrogen metabolism_Homo sapiens_hsa009101.01611559
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01329813
49Type I diabetes mellitus_Homo sapiens_hsa049400.98527574
50Epstein-Barr virus infection_Homo sapiens_hsa051690.98337004
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98173628
52Asthma_Homo sapiens_hsa053100.97086515
53One carbon pool by folate_Homo sapiens_hsa006700.96265897
54Autoimmune thyroid disease_Homo sapiens_hsa053200.96257572
55Fatty acid elongation_Homo sapiens_hsa000620.95235172
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94410093
57Cardiac muscle contraction_Homo sapiens_hsa042600.94178299
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92011807
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89013628
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87154910
61Caffeine metabolism_Homo sapiens_hsa002320.82371034
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81863213
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77367757
64Fanconi anemia pathway_Homo sapiens_hsa034600.76602504
65Chemical carcinogenesis_Homo sapiens_hsa052040.74882446
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73319522
67Legionellosis_Homo sapiens_hsa051340.72813833
68beta-Alanine metabolism_Homo sapiens_hsa004100.70123116
69Sphingolipid metabolism_Homo sapiens_hsa006000.69332434
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65714493
71Cell cycle_Homo sapiens_hsa041100.64793433
72Retinol metabolism_Homo sapiens_hsa008300.63574938
73Folate biosynthesis_Homo sapiens_hsa007900.62105137
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61749614
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.61629043
76Morphine addiction_Homo sapiens_hsa050320.61155843
77GABAergic synapse_Homo sapiens_hsa047270.60778362
78Arachidonic acid metabolism_Homo sapiens_hsa005900.59913781
79Metabolic pathways_Homo sapiens_hsa011000.59467191
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57840137
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56971730
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.55486355
83Insulin secretion_Homo sapiens_hsa049110.55210740
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54537429
85Glutathione metabolism_Homo sapiens_hsa004800.54504481
86Phototransduction_Homo sapiens_hsa047440.53994499
87Serotonergic synapse_Homo sapiens_hsa047260.52921935
88Fat digestion and absorption_Homo sapiens_hsa049750.51591821
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50361187
90Ether lipid metabolism_Homo sapiens_hsa005650.50195274
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48970988
92Nicotine addiction_Homo sapiens_hsa050330.48379354
93Mineral absorption_Homo sapiens_hsa049780.48200192
94Vitamin B6 metabolism_Homo sapiens_hsa007500.45837005
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44849029
96Fatty acid metabolism_Homo sapiens_hsa012120.44581561
97Antigen processing and presentation_Homo sapiens_hsa046120.44233049
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42908009
99Shigellosis_Homo sapiens_hsa051310.42353509
100Dopaminergic synapse_Homo sapiens_hsa047280.41316346
101Glutamatergic synapse_Homo sapiens_hsa047240.39898792
102Vitamin digestion and absorption_Homo sapiens_hsa049770.39028731
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.38500638
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38225424
105p53 signaling pathway_Homo sapiens_hsa041150.36727785
106Pentose phosphate pathway_Homo sapiens_hsa000300.35997810
107Cocaine addiction_Homo sapiens_hsa050300.35287979
108Salmonella infection_Homo sapiens_hsa051320.34568334
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33054419
110Circadian entrainment_Homo sapiens_hsa047130.32027456
111Pertussis_Homo sapiens_hsa051330.31412800
112Tyrosine metabolism_Homo sapiens_hsa003500.31002046
113Primary immunodeficiency_Homo sapiens_hsa053400.29933008
114Measles_Homo sapiens_hsa051620.28989738
115mRNA surveillance pathway_Homo sapiens_hsa030150.28901302
116Fatty acid degradation_Homo sapiens_hsa000710.28769266
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28674041
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28286861
119Non-homologous end-joining_Homo sapiens_hsa034500.28124022
120African trypanosomiasis_Homo sapiens_hsa051430.27522733
121N-Glycan biosynthesis_Homo sapiens_hsa005100.27340320
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26845132
123Hematopoietic cell lineage_Homo sapiens_hsa046400.26796109
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26119861
125Axon guidance_Homo sapiens_hsa043600.25801284
126Hedgehog signaling pathway_Homo sapiens_hsa043400.25640926
127Sulfur relay system_Homo sapiens_hsa041220.24541874
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.24087552
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21839793
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20858669
131Pyruvate metabolism_Homo sapiens_hsa006200.20593110
132Olfactory transduction_Homo sapiens_hsa047400.20485483
133Herpes simplex infection_Homo sapiens_hsa051680.20100522
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18800662
135Fructose and mannose metabolism_Homo sapiens_hsa000510.18311899
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17368654
137Oocyte meiosis_Homo sapiens_hsa041140.16943736
138Alcoholism_Homo sapiens_hsa050340.15968580
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14193459
140Leishmaniasis_Homo sapiens_hsa051400.12959197
141Lysosome_Homo sapiens_hsa041420.11091649
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10933079
143Taste transduction_Homo sapiens_hsa047420.10849239
144Sulfur metabolism_Homo sapiens_hsa009200.10146172

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