

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.65441976 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.26509244 |
| 3 | chaperone-mediated protein transport (GO:0072321) | 5.21660005 |
| 4 | protein neddylation (GO:0045116) | 4.96331534 |
| 5 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.92440451 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.85618234 |
| 7 | ATP synthesis coupled proton transport (GO:0015986) | 4.85618234 |
| 8 | cullin deneddylation (GO:0010388) | 4.82002120 |
| 9 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.76306802 |
| 10 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.55926086 |
| 11 | negative regulation of ligase activity (GO:0051352) | 4.54872148 |
| 12 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.54872148 |
| 13 | protein deneddylation (GO:0000338) | 4.50428963 |
| 14 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.45332364 |
| 15 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.42639959 |
| 16 | behavioral response to nicotine (GO:0035095) | 4.37604938 |
| 17 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 4.31479456 |
| 18 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.31371356 |
| 19 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.31371356 |
| 20 | termination of RNA polymerase III transcription (GO:0006386) | 4.30706301 |
| 21 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.30706301 |
| 22 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.29265366 |
| 23 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.28741116 |
| 24 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.28741116 |
| 25 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.28741116 |
| 26 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.14193194 |
| 27 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.11734185 |
| 28 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.11734185 |
| 29 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.11203783 |
| 30 | protein complex biogenesis (GO:0070271) | 4.09006054 |
| 31 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.08353527 |
| 32 | 7-methylguanosine RNA capping (GO:0009452) | 4.06145836 |
| 33 | RNA capping (GO:0036260) | 4.06145836 |
| 34 | 7-methylguanosine mRNA capping (GO:0006370) | 4.05612366 |
| 35 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 4.05278157 |
| 36 | respiratory electron transport chain (GO:0022904) | 4.01750867 |
| 37 | electron transport chain (GO:0022900) | 3.93341191 |
| 38 | ribosomal small subunit assembly (GO:0000028) | 3.93286999 |
| 39 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.90639070 |
| 40 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.90639070 |
| 41 | NADH dehydrogenase complex assembly (GO:0010257) | 3.90639070 |
| 42 | DNA deamination (GO:0045006) | 3.90285427 |
| 43 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.79315885 |
| 44 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.69591142 |
| 45 | protein targeting to mitochondrion (GO:0006626) | 3.67639876 |
| 46 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.66242998 |
| 47 | positive regulation of ligase activity (GO:0051351) | 3.65475000 |
| 48 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.64242686 |
| 49 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.64242686 |
| 50 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.62705498 |
| 51 | establishment of protein localization to mitochondrion (GO:0072655) | 3.60081696 |
| 52 | ribosomal small subunit biogenesis (GO:0042274) | 3.59425862 |
| 53 | regulation of mitochondrial translation (GO:0070129) | 3.57899534 |
| 54 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.56898323 |
| 55 | GTP biosynthetic process (GO:0006183) | 3.47170530 |
| 56 | regulation of cellular amine metabolic process (GO:0033238) | 3.47116156 |
| 57 | respiratory chain complex IV assembly (GO:0008535) | 3.46406877 |
| 58 | peptidyl-histidine modification (GO:0018202) | 3.37899214 |
| 59 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.35856443 |
| 60 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.35836506 |
| 61 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.33622124 |
| 62 | hydrogen ion transmembrane transport (GO:1902600) | 3.33352044 |
| 63 | protein localization to mitochondrion (GO:0070585) | 3.31776294 |
| 64 | cytochrome complex assembly (GO:0017004) | 3.31664344 |
| 65 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.30027152 |
| 66 | positive regulation of cell cycle arrest (GO:0071158) | 3.27513481 |
| 67 | regulation of ligase activity (GO:0051340) | 3.24025795 |
| 68 | maturation of SSU-rRNA (GO:0030490) | 3.20075783 |
| 69 | viral transcription (GO:0019083) | 3.17229509 |
| 70 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.16862302 |
| 71 | platelet dense granule organization (GO:0060155) | 3.16587937 |
| 72 | ATP biosynthetic process (GO:0006754) | 3.15624546 |
| 73 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.14250497 |
| 74 | proton transport (GO:0015992) | 3.14033125 |
| 75 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.14027333 |
| 76 | negative regulation of telomere maintenance (GO:0032205) | 3.12795709 |
| 77 | intracellular protein transmembrane import (GO:0044743) | 3.11954259 |
| 78 | translation (GO:0006412) | 3.11343758 |
| 79 | de novo posttranslational protein folding (GO:0051084) | 3.11187110 |
| 80 | tRNA processing (GO:0008033) | 3.10565256 |
| 81 | cellular component biogenesis (GO:0044085) | 3.10507939 |
| 82 | de novo protein folding (GO:0006458) | 3.08802660 |
| 83 | positive regulation of mitochondrial fission (GO:0090141) | 3.07445572 |
| 84 | cotranslational protein targeting to membrane (GO:0006613) | 3.06475369 |
| 85 | hydrogen transport (GO:0006818) | 3.05943588 |
| 86 | ribosomal large subunit biogenesis (GO:0042273) | 3.05838704 |
| 87 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.04689073 |
| 88 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.04689073 |
| 89 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.04187656 |
| 90 | epithelial cilium movement (GO:0003351) | 3.03422995 |
| 91 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.03282807 |
| 92 | translational termination (GO:0006415) | 3.02450456 |
| 93 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.99307330 |
| 94 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 2.98958766 |
| 95 | protein targeting to ER (GO:0045047) | 2.97478770 |
| 96 | iron-sulfur cluster assembly (GO:0016226) | 2.97177476 |
| 97 | metallo-sulfur cluster assembly (GO:0031163) | 2.97177476 |
| 98 | rRNA modification (GO:0000154) | 2.95079408 |
| 99 | negative regulation of protein ubiquitination (GO:0031397) | 2.94756530 |
| 100 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.94650354 |
| 101 | pseudouridine synthesis (GO:0001522) | 2.94475814 |
| 102 | UTP biosynthetic process (GO:0006228) | 2.93411794 |
| 103 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.92768481 |
| 104 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.92768481 |
| 105 | protein localization to endoplasmic reticulum (GO:0070972) | 2.91162102 |
| 106 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.88371540 |
| 107 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.83964313 |
| 108 | signal transduction in response to DNA damage (GO:0042770) | 2.83497277 |
| 109 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.83220113 |
| 110 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.82421522 |
| 111 | nucleobase catabolic process (GO:0046113) | 2.82225397 |
| 112 | protein-cofactor linkage (GO:0018065) | 2.82114773 |
| 113 | DNA damage response, detection of DNA damage (GO:0042769) | 2.81696904 |
| 114 | transcription from RNA polymerase I promoter (GO:0006360) | 2.80286500 |
| 115 | GMP metabolic process (GO:0046037) | 2.79549938 |
| 116 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.79046700 |
| 117 | response to pheromone (GO:0019236) | 2.77085430 |
| 118 | spliceosomal snRNP assembly (GO:0000387) | 2.74746280 |
| 119 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.74134390 |
| 120 | regulation of cilium movement (GO:0003352) | 2.73491568 |
| 121 | positive regulation of protein homodimerization activity (GO:0090073) | 2.72368005 |
| 122 | ubiquinone metabolic process (GO:0006743) | 2.67343051 |
| 123 | tRNA metabolic process (GO:0006399) | 2.67126302 |
| 124 | mannosylation (GO:0097502) | 2.66053665 |
| 125 | sequestering of actin monomers (GO:0042989) | 2.65973490 |
| 126 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.65210247 |
| 127 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.61270348 |
| 128 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.61270348 |
| 129 | ubiquinone biosynthetic process (GO:0006744) | 2.60596801 |
| 130 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.60093611 |
| 131 | protein polyglutamylation (GO:0018095) | 2.56618034 |
| 132 | retinal ganglion cell axon guidance (GO:0031290) | 2.53417650 |
| 133 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.52174722 |
| 134 | cellular ketone body metabolic process (GO:0046950) | 2.51471433 |
| 135 | inner mitochondrial membrane organization (GO:0007007) | 2.51230263 |
| 136 | rRNA methylation (GO:0031167) | 2.51098823 |
| 137 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.50440709 |
| 138 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.48499575 |
| 139 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.46482395 |
| 140 | tRNA modification (GO:0006400) | 2.44703635 |
| 141 | base-excision repair, AP site formation (GO:0006285) | 2.44293923 |
| 142 | cilium movement (GO:0003341) | 2.43250045 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.06578079 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.73667121 |
| 3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.45933447 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.27075238 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.08040991 |
| 6 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.74827399 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.61643171 |
| 8 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.58309213 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.49378397 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.45085029 |
| 11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.42546568 |
| 12 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.39154624 |
| 13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.38021471 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.13108605 |
| 15 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.98313824 |
| 16 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.90766285 |
| 17 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.86412701 |
| 18 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.76466023 |
| 19 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.69163102 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.68127287 |
| 21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.63629880 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.62711620 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.56078316 |
| 24 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.47728257 |
| 25 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.31309727 |
| 26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.26942106 |
| 27 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.24971568 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.22819495 |
| 29 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.20483493 |
| 30 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.10451424 |
| 31 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.02445835 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.01761134 |
| 33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.98113989 |
| 34 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.94207595 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.92519323 |
| 36 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.92362160 |
| 37 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.70379358 |
| 38 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.67066093 |
| 39 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.66991770 |
| 40 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.66578941 |
| 41 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66461507 |
| 42 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.66360790 |
| 43 | EWS_26573619_Chip-Seq_HEK293_Human | 1.63969049 |
| 44 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.61999809 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.60916170 |
| 46 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60277192 |
| 47 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.60152066 |
| 48 | FUS_26573619_Chip-Seq_HEK293_Human | 1.58668336 |
| 49 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.51129493 |
| 50 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.48969260 |
| 51 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.47457725 |
| 52 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.43844079 |
| 53 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.38693303 |
| 54 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.38007370 |
| 55 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.37188383 |
| 56 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.37133890 |
| 57 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.34807704 |
| 58 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.34659686 |
| 59 | P300_19829295_ChIP-Seq_ESCs_Human | 1.34061504 |
| 60 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.33957335 |
| 61 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.33247367 |
| 62 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.30529369 |
| 63 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.26943799 |
| 64 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.25248958 |
| 65 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.24358895 |
| 66 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.23645742 |
| 67 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.23297706 |
| 68 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.22186049 |
| 69 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.21196208 |
| 70 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.21084315 |
| 71 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.20784002 |
| 72 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.20121587 |
| 73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.18833965 |
| 74 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.17958882 |
| 75 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.17085954 |
| 76 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.17085954 |
| 77 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.16660551 |
| 78 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16579169 |
| 79 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.14732327 |
| 80 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.14588811 |
| 81 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.13440289 |
| 82 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.13005654 |
| 83 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.12356312 |
| 84 | NCOR_22424771_ChIP-Seq_293T_Human | 1.10846141 |
| 85 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.10593378 |
| 86 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.09213424 |
| 87 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.08110076 |
| 88 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.07589466 |
| 89 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.06154968 |
| 90 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.05979170 |
| 91 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.05898534 |
| 92 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.05436251 |
| 93 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.04707114 |
| 94 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.04535631 |
| 95 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.04018333 |
| 96 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.03596512 |
| 97 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.02512228 |
| 98 | VDR_22108803_ChIP-Seq_LS180_Human | 1.02267773 |
| 99 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.01234499 |
| 100 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.99497748 |
| 101 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.99067845 |
| 102 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.96818780 |
| 103 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.96206673 |
| 104 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.96091809 |
| 105 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.96057253 |
| 106 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.95598916 |
| 107 | AR_25329375_ChIP-Seq_VCAP_Human | 0.94002748 |
| 108 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.93013447 |
| 109 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.93013447 |
| 110 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.92932870 |
| 111 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.92932870 |
| 112 | AR_20517297_ChIP-Seq_VCAP_Human | 0.91417227 |
| 113 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90874415 |
| 114 | * EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.90846186 |
| 115 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.90833503 |
| 116 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.90794462 |
| 117 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.90275509 |
| 118 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.89377568 |
| 119 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.89242045 |
| 120 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.88505092 |
| 121 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.85702328 |
| 122 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85555298 |
| 123 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.85514047 |
| 124 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.85077719 |
| 125 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84522447 |
| 126 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.83750013 |
| 127 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.83448587 |
| 128 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.83372221 |
| 129 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.83175484 |
| 130 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.81420328 |
| 131 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.76811160 |
| 132 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.76735514 |
| 133 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.75051732 |
| 134 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.72622621 |
| 135 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.71133341 |
| 136 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.71078909 |
| 137 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.70857647 |
| 138 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.70764373 |
| 139 | * RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.68352596 |
| 140 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.67212189 |
| 141 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.66278716 |
| 142 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.64313429 |
| 143 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.64312071 |
| 144 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.64241005 |
| 145 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.63769411 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001529_abnormal_vocalization | 3.39732746 |
| 2 | MP0003787_abnormal_imprinting | 3.04083043 |
| 3 | MP0006276_abnormal_autonomic_nervous | 2.95835300 |
| 4 | MP0003880_abnormal_central_pattern | 2.92560669 |
| 5 | MP0001905_abnormal_dopamine_level | 2.90432164 |
| 6 | MP0008260_abnormal_autophagy | 2.89173693 |
| 7 | MP0001986_abnormal_taste_sensitivity | 2.77609007 |
| 8 | MP0009379_abnormal_foot_pigmentation | 2.44123645 |
| 9 | MP0003693_abnormal_embryo_hatching | 2.42035067 |
| 10 | MP0002736_abnormal_nociception_after | 2.41260153 |
| 11 | MP0002735_abnormal_chemical_nociception | 2.38618180 |
| 12 | MP0002837_dystrophic_cardiac_calcinosis | 2.23897126 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.20443859 |
| 14 | MP0001188_hyperpigmentation | 2.04260080 |
| 15 | MP0003121_genomic_imprinting | 2.03400097 |
| 16 | MP0003011_delayed_dark_adaptation | 2.02579654 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 1.98878327 |
| 18 | MP0002653_abnormal_ependyma_morphology | 1.91862687 |
| 19 | MP0000372_irregular_coat_pigmentation | 1.85439192 |
| 20 | MP0006035_abnormal_mitochondrial_morpho | 1.81385990 |
| 21 | MP0004133_heterotaxia | 1.81340105 |
| 22 | MP0005551_abnormal_eye_electrophysiolog | 1.79648561 |
| 23 | MP0003123_paternal_imprinting | 1.77706063 |
| 24 | MP0003315_abnormal_perineum_morphology | 1.74513649 |
| 25 | MP0004957_abnormal_blastocyst_morpholog | 1.72847721 |
| 26 | MP0002751_abnormal_autonomic_nervous | 1.72683179 |
| 27 | MP0009333_abnormal_splenocyte_physiolog | 1.72185261 |
| 28 | MP0003718_maternal_effect | 1.68646401 |
| 29 | MP0002876_abnormal_thyroid_physiology | 1.68021802 |
| 30 | MP0001984_abnormal_olfaction | 1.66918421 |
| 31 | MP0008932_abnormal_embryonic_tissue | 1.65628532 |
| 32 | MP0003186_abnormal_redox_activity | 1.65334780 |
| 33 | MP0008789_abnormal_olfactory_epithelium | 1.62451249 |
| 34 | MP0002163_abnormal_gland_morphology | 1.62204232 |
| 35 | MP0006292_abnormal_olfactory_placode | 1.58883533 |
| 36 | MP0001970_abnormal_pain_threshold | 1.58245406 |
| 37 | MP0004270_analgesia | 1.57721277 |
| 38 | MP0009785_altered_susceptibility_to | 1.57302959 |
| 39 | MP0003183_abnormal_peptide_metabolism | 1.57177432 |
| 40 | MP0002132_abnormal_respiratory_system | 1.56169886 |
| 41 | MP0002733_abnormal_thermal_nociception | 1.55604577 |
| 42 | MP0008058_abnormal_DNA_repair | 1.54726025 |
| 43 | MP0008872_abnormal_physiological_respon | 1.53764005 |
| 44 | MP0004147_increased_porphyrin_level | 1.51412528 |
| 45 | MP0006036_abnormal_mitochondrial_physio | 1.50993645 |
| 46 | MP0004142_abnormal_muscle_tone | 1.48398079 |
| 47 | MP0002148_abnormal_hypersensitivity_rea | 1.45560948 |
| 48 | MP0002638_abnormal_pupillary_reflex | 1.44612905 |
| 49 | MP0009697_abnormal_copulation | 1.44456162 |
| 50 | MP0008875_abnormal_xenobiotic_pharmacok | 1.43629166 |
| 51 | MP0005084_abnormal_gallbladder_morpholo | 1.42670940 |
| 52 | MP0002184_abnormal_innervation | 1.39449755 |
| 53 | MP0002272_abnormal_nervous_system | 1.36294817 |
| 54 | MP0003195_calcinosis | 1.35693910 |
| 55 | MP0004885_abnormal_endolymph | 1.35683842 |
| 56 | MP0001835_abnormal_antigen_presentation | 1.35546400 |
| 57 | MP0005645_abnormal_hypothalamus_physiol | 1.35021247 |
| 58 | MP0002557_abnormal_social/conspecific_i | 1.33460228 |
| 59 | MP0001440_abnormal_grooming_behavior | 1.33054130 |
| 60 | MP0001542_abnormal_bone_strength | 1.31444597 |
| 61 | MP0003786_premature_aging | 1.29094693 |
| 62 | MP0005499_abnormal_olfactory_system | 1.28467386 |
| 63 | MP0005394_taste/olfaction_phenotype | 1.28467386 |
| 64 | MP0005253_abnormal_eye_physiology | 1.24898900 |
| 65 | MP0004782_abnormal_surfactant_physiolog | 1.22185033 |
| 66 | MP0005671_abnormal_response_to | 1.21645326 |
| 67 | MP0002064_seizures | 1.21490642 |
| 68 | MP0009046_muscle_twitch | 1.20764243 |
| 69 | MP0000015_abnormal_ear_pigmentation | 1.18239963 |
| 70 | MP0001919_abnormal_reproductive_system | 1.17616206 |
| 71 | MP0002277_abnormal_respiratory_mucosa | 1.16255447 |
| 72 | MP0001293_anophthalmia | 1.15985461 |
| 73 | MP0002909_abnormal_adrenal_gland | 1.13631672 |
| 74 | MP0009745_abnormal_behavioral_response | 1.13582438 |
| 75 | MP0003077_abnormal_cell_cycle | 1.13148162 |
| 76 | MP0002822_catalepsy | 1.12273206 |
| 77 | MP0010386_abnormal_urinary_bladder | 1.12253814 |
| 78 | MP0002102_abnormal_ear_morphology | 1.11016380 |
| 79 | MP0000778_abnormal_nervous_system | 1.09930190 |
| 80 | MP0005423_abnormal_somatic_nervous | 1.09385569 |
| 81 | MP0003436_decreased_susceptibility_to | 1.08558201 |
| 82 | MP0000427_abnormal_hair_cycle | 1.06633983 |
| 83 | MP0005195_abnormal_posterior_eye | 1.06283784 |
| 84 | MP0003136_yellow_coat_color | 1.05713746 |
| 85 | MP0008007_abnormal_cellular_replicative | 1.05506028 |
| 86 | MP0005000_abnormal_immune_tolerance | 1.05275215 |
| 87 | MP0008877_abnormal_DNA_methylation | 1.03219732 |
| 88 | MP0002210_abnormal_sex_determination | 1.02561012 |
| 89 | MP0002572_abnormal_emotion/affect_behav | 1.02375999 |
| 90 | MP0008995_early_reproductive_senescence | 1.01059322 |
| 91 | MP0000955_abnormal_spinal_cord | 1.00111868 |
| 92 | MP0005646_abnormal_pituitary_gland | 0.99200172 |
| 93 | MP0001727_abnormal_embryo_implantation | 0.98298128 |
| 94 | MP0002067_abnormal_sensory_capabilities | 0.98098092 |
| 95 | MP0003724_increased_susceptibility_to | 0.96460978 |
| 96 | MP0002882_abnormal_neuron_morphology | 0.93003395 |
| 97 | MP0005379_endocrine/exocrine_gland_phen | 0.91204360 |
| 98 | MP0004145_abnormal_muscle_electrophysio | 0.90198484 |
| 99 | MP0001486_abnormal_startle_reflex | 0.90182715 |
| 100 | MP0006082_CNS_inflammation | 0.90111558 |
| 101 | MP0002063_abnormal_learning/memory/cond | 0.90105938 |
| 102 | MP0005386_behavior/neurological_phenoty | 0.89958273 |
| 103 | MP0004924_abnormal_behavior | 0.89958273 |
| 104 | MP0003890_abnormal_embryonic-extraembry | 0.89779852 |
| 105 | MP0004742_abnormal_vestibular_system | 0.89776915 |
| 106 | MP0003646_muscle_fatigue | 0.88601362 |
| 107 | MP0000681_abnormal_thyroid_gland | 0.88302233 |
| 108 | MP0003635_abnormal_synaptic_transmissio | 0.88258562 |
| 109 | MP0002160_abnormal_reproductive_system | 0.88068698 |
| 110 | MP0002234_abnormal_pharynx_morphology | 0.87859512 |
| 111 | MP0005171_absent_coat_pigmentation | 0.87113673 |
| 112 | MP0005174_abnormal_tail_pigmentation | 0.86947755 |
| 113 | MP0002229_neurodegeneration | 0.86075293 |
| 114 | MP0005332_abnormal_amino_acid | 0.85079096 |
| 115 | MP0000358_abnormal_cell_content/ | 0.84936226 |
| 116 | MP0001485_abnormal_pinna_reflex | 0.82784240 |
| 117 | MP0005025_abnormal_response_to | 0.81376707 |
| 118 | MP0003283_abnormal_digestive_organ | 0.80759412 |
| 119 | MP0004859_abnormal_synaptic_plasticity | 0.80708807 |
| 120 | MP0010094_abnormal_chromosome_stability | 0.80195445 |
| 121 | MP0003806_abnormal_nucleotide_metabolis | 0.79736602 |
| 122 | MP0002752_abnormal_somatic_nervous | 0.79522168 |
| 123 | MP0002332_abnormal_exercise_endurance | 0.78180316 |
| 124 | MP0002090_abnormal_vision | 0.77140450 |
| 125 | MP0002938_white_spotting | 0.77074308 |
| 126 | MP0002693_abnormal_pancreas_physiology | 0.76801740 |
| 127 | MP0001348_abnormal_lacrimal_gland | 0.75327812 |
| 128 | MP0005389_reproductive_system_phenotype | 0.75261917 |
| 129 | MP0001501_abnormal_sleep_pattern | 0.74499090 |
| 130 | MP0001963_abnormal_hearing_physiology | 0.74443329 |
| 131 | MP0003122_maternal_imprinting | 0.73854223 |
| 132 | MP0005075_abnormal_melanosome_morpholog | 0.73319000 |
| 133 | MP0000026_abnormal_inner_ear | 0.71723754 |
| 134 | MP0002095_abnormal_skin_pigmentation | 0.69034322 |
| 135 | MP0000631_abnormal_neuroendocrine_gland | 0.68630514 |
| 136 | MP0006072_abnormal_retinal_apoptosis | 0.68046580 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.99371649 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.33634169 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.00355409 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.89505599 |
| 5 | Acute encephalopathy (HP:0006846) | 4.46888850 |
| 6 | Increased CSF lactate (HP:0002490) | 4.35538697 |
| 7 | Increased serum pyruvate (HP:0003542) | 4.29081752 |
| 8 | Abnormality of glycolysis (HP:0004366) | 4.29081752 |
| 9 | Hepatocellular necrosis (HP:0001404) | 4.22326956 |
| 10 | 3-Methylglutaconic aciduria (HP:0003535) | 3.82877691 |
| 11 | Molar tooth sign on MRI (HP:0002419) | 3.56153279 |
| 12 | Abnormality of midbrain morphology (HP:0002418) | 3.56153279 |
| 13 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.45770287 |
| 14 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.45770287 |
| 15 | Hepatic necrosis (HP:0002605) | 3.38571951 |
| 16 | Increased hepatocellular lipid droplets (HP:0006565) | 3.37906936 |
| 17 | Cerebral hypomyelination (HP:0006808) | 3.36302446 |
| 18 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.28763911 |
| 19 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.15081272 |
| 20 | Nephronophthisis (HP:0000090) | 3.07921586 |
| 21 | Neuroendocrine neoplasm (HP:0100634) | 3.05947976 |
| 22 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.02736072 |
| 23 | Increased serum lactate (HP:0002151) | 3.01027702 |
| 24 | Renal Fanconi syndrome (HP:0001994) | 2.96680604 |
| 25 | Abnormal hair whorl (HP:0010721) | 2.95832458 |
| 26 | Hypothermia (HP:0002045) | 2.93764583 |
| 27 | Optic disc pallor (HP:0000543) | 2.91459817 |
| 28 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.91108899 |
| 29 | Respiratory failure (HP:0002878) | 2.90944431 |
| 30 | Leukodystrophy (HP:0002415) | 2.88502362 |
| 31 | Type II lissencephaly (HP:0007260) | 2.88321055 |
| 32 | Exercise intolerance (HP:0003546) | 2.84666591 |
| 33 | Lactic acidosis (HP:0003128) | 2.81525611 |
| 34 | Parakeratosis (HP:0001036) | 2.80015055 |
| 35 | Poor suck (HP:0002033) | 2.77486713 |
| 36 | Pheochromocytoma (HP:0002666) | 2.75604706 |
| 37 | Medial flaring of the eyebrow (HP:0010747) | 2.74399312 |
| 38 | Lipid accumulation in hepatocytes (HP:0006561) | 2.72157102 |
| 39 | Birth length less than 3rd percentile (HP:0003561) | 2.64882430 |
| 40 | Abnormal number of erythroid precursors (HP:0012131) | 2.61060058 |
| 41 | Cerebral edema (HP:0002181) | 2.61003228 |
| 42 | Exertional dyspnea (HP:0002875) | 2.60304297 |
| 43 | Type I transferrin isoform profile (HP:0003642) | 2.59275416 |
| 44 | Aplastic anemia (HP:0001915) | 2.57964812 |
| 45 | Congenital stationary night blindness (HP:0007642) | 2.49802689 |
| 46 | Methylmalonic acidemia (HP:0002912) | 2.47912914 |
| 47 | Respiratory difficulties (HP:0002880) | 2.46523222 |
| 48 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.44892698 |
| 49 | Sclerocornea (HP:0000647) | 2.44820115 |
| 50 | Abnormality of the renal medulla (HP:0100957) | 2.43921108 |
| 51 | Reticulocytopenia (HP:0001896) | 2.39117480 |
| 52 | Type 2 muscle fiber atrophy (HP:0003554) | 2.32097137 |
| 53 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.21737246 |
| 54 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.21737246 |
| 55 | Abnormal protein glycosylation (HP:0012346) | 2.21737246 |
| 56 | Abnormal glycosylation (HP:0012345) | 2.21737246 |
| 57 | Increased intramyocellular lipid droplets (HP:0012240) | 2.20573737 |
| 58 | Congenital, generalized hypertrichosis (HP:0004540) | 2.19911144 |
| 59 | Glycosuria (HP:0003076) | 2.19750555 |
| 60 | Abnormality of urine glucose concentration (HP:0011016) | 2.19750555 |
| 61 | Muscle fiber atrophy (HP:0100295) | 2.18293886 |
| 62 | Abolished electroretinogram (ERG) (HP:0000550) | 2.17430121 |
| 63 | Gait imbalance (HP:0002141) | 2.17261635 |
| 64 | Microvesicular hepatic steatosis (HP:0001414) | 2.17210341 |
| 65 | Methylmalonic aciduria (HP:0012120) | 2.16851447 |
| 66 | Lethargy (HP:0001254) | 2.16776814 |
| 67 | Pendular nystagmus (HP:0012043) | 2.14089343 |
| 68 | Abnormality of the anterior horn cell (HP:0006802) | 2.14004974 |
| 69 | Degeneration of anterior horn cells (HP:0002398) | 2.14004974 |
| 70 | Nephrogenic diabetes insipidus (HP:0009806) | 2.13750803 |
| 71 | Rough bone trabeculation (HP:0100670) | 2.12410948 |
| 72 | Vaginal atresia (HP:0000148) | 2.09132915 |
| 73 | CNS hypomyelination (HP:0003429) | 2.08606189 |
| 74 | Cystic liver disease (HP:0006706) | 2.08336980 |
| 75 | Congenital primary aphakia (HP:0007707) | 2.08187222 |
| 76 | Genital tract atresia (HP:0001827) | 2.07393532 |
| 77 | Limb dystonia (HP:0002451) | 2.05691528 |
| 78 | Abnormality of the renal cortex (HP:0011035) | 2.04825766 |
| 79 | Colon cancer (HP:0003003) | 2.04489434 |
| 80 | Myokymia (HP:0002411) | 2.03627023 |
| 81 | Pallor (HP:0000980) | 2.02455204 |
| 82 | Autoamputation (HP:0001218) | 2.02033207 |
| 83 | Increased IgM level (HP:0003496) | 2.00544341 |
| 84 | Lissencephaly (HP:0001339) | 2.00151664 |
| 85 | Septo-optic dysplasia (HP:0100842) | 1.99341984 |
| 86 | Absent thumb (HP:0009777) | 1.99280115 |
| 87 | Abnormal biliary tract physiology (HP:0012439) | 1.98105475 |
| 88 | Bile duct proliferation (HP:0001408) | 1.98105475 |
| 89 | Adrenal hypoplasia (HP:0000835) | 1.97717133 |
| 90 | CNS demyelination (HP:0007305) | 1.97060651 |
| 91 | Emotional lability (HP:0000712) | 1.96357091 |
| 92 | Polyphagia (HP:0002591) | 1.96250586 |
| 93 | Pachygyria (HP:0001302) | 1.94996777 |
| 94 | Hyperglycinemia (HP:0002154) | 1.94413101 |
| 95 | Poor head control (HP:0002421) | 1.94320311 |
| 96 | Anencephaly (HP:0002323) | 1.92156869 |
| 97 | Macrocytic anemia (HP:0001972) | 1.90669486 |
| 98 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.89763973 |
| 99 | Delusions (HP:0000746) | 1.89682786 |
| 100 | Breast hypoplasia (HP:0003187) | 1.89040748 |
| 101 | Failure to thrive in infancy (HP:0001531) | 1.88688283 |
| 102 | Hypoplasia of the pons (HP:0012110) | 1.88047058 |
| 103 | Irregular epiphyses (HP:0010582) | 1.87786568 |
| 104 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.86861440 |
| 105 | Abnormality of the pons (HP:0007361) | 1.85684935 |
| 106 | Abnormality of placental membranes (HP:0011409) | 1.85179756 |
| 107 | Amniotic constriction ring (HP:0009775) | 1.85179756 |
| 108 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.84563685 |
| 109 | Abnormality of the labia minora (HP:0012880) | 1.84209683 |
| 110 | Hyperphosphaturia (HP:0003109) | 1.83920495 |
| 111 | Tubular atrophy (HP:0000092) | 1.81838316 |
| 112 | Male pseudohermaphroditism (HP:0000037) | 1.80630172 |
| 113 | Optic nerve hypoplasia (HP:0000609) | 1.79606770 |
| 114 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.79454836 |
| 115 | Abnormality of renal resorption (HP:0011038) | 1.79228472 |
| 116 | Abnormal drinking behavior (HP:0030082) | 1.78963212 |
| 117 | Polydipsia (HP:0001959) | 1.78963212 |
| 118 | Tachypnea (HP:0002789) | 1.78639413 |
| 119 | Abnormal ciliary motility (HP:0012262) | 1.78244395 |
| 120 | Supernumerary spleens (HP:0009799) | 1.76637789 |
| 121 | Concave nail (HP:0001598) | 1.73793172 |
| 122 | Pancreatic fibrosis (HP:0100732) | 1.73728405 |
| 123 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.73578716 |
| 124 | Severe muscular hypotonia (HP:0006829) | 1.73278242 |
| 125 | Renal cortical cysts (HP:0000803) | 1.73195986 |
| 126 | Esotropia (HP:0000565) | 1.72489971 |
| 127 | Generalized aminoaciduria (HP:0002909) | 1.72292542 |
| 128 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.72228305 |
| 129 | Poor coordination (HP:0002370) | 1.71649462 |
| 130 | Bone marrow hypocellularity (HP:0005528) | 1.71638366 |
| 131 | Oral leukoplakia (HP:0002745) | 1.70555589 |
| 132 | Abnormal pupillary function (HP:0007686) | 1.69489807 |
| 133 | X-linked dominant inheritance (HP:0001423) | 1.68588504 |
| 134 | Postnatal microcephaly (HP:0005484) | 1.66603394 |
| 135 | Pancytopenia (HP:0001876) | 1.65455556 |
| 136 | Prolonged neonatal jaundice (HP:0006579) | 1.64844379 |
| 137 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.64177506 |
| 138 | Abnormality of alanine metabolism (HP:0010916) | 1.64177506 |
| 139 | Hyperalaninemia (HP:0003348) | 1.64177506 |
| 140 | Abnormal trabecular bone morphology (HP:0100671) | 1.63787556 |
| 141 | True hermaphroditism (HP:0010459) | 1.62783934 |
| 142 | Carpal bone hypoplasia (HP:0001498) | 1.62361207 |
| 143 | Retinal dysplasia (HP:0007973) | 1.61053853 |
| 144 | Pancreatic cysts (HP:0001737) | 1.60501415 |
| 145 | Oligomenorrhea (HP:0000876) | 1.59595616 |
| 146 | Increased muscle lipid content (HP:0009058) | 1.59276388 |
| 147 | Abnormal autonomic nervous system physiology (HP:0012332) | 1.59159079 |
| 148 | Atonic seizures (HP:0010819) | 1.58340747 |
| 149 | Neoplasm of the adrenal gland (HP:0100631) | 1.58027926 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 3.94765449 |
| 2 | STK16 | 3.61269296 |
| 3 | MAP3K12 | 3.23045027 |
| 4 | VRK2 | 2.80162921 |
| 5 | WNK4 | 2.67116174 |
| 6 | NME2 | 2.64878720 |
| 7 | MAP3K4 | 2.46490041 |
| 8 | FRK | 2.35757732 |
| 9 | MAP4K2 | 2.34463652 |
| 10 | TSSK6 | 2.31697932 |
| 11 | MST4 | 2.31047792 |
| 12 | SIK3 | 2.23889885 |
| 13 | EIF2AK1 | 2.22194585 |
| 14 | PIM2 | 2.20750711 |
| 15 | DYRK2 | 2.14855746 |
| 16 | LIMK1 | 2.09166160 |
| 17 | GRK1 | 2.07127981 |
| 18 | ARAF | 2.06392416 |
| 19 | VRK1 | 2.03157091 |
| 20 | NUAK1 | 2.02415847 |
| 21 | CASK | 2.00630127 |
| 22 | TRIM28 | 2.00341699 |
| 23 | NME1 | 1.93958277 |
| 24 | MARK1 | 1.93849244 |
| 25 | BCR | 1.93029505 |
| 26 | CDK19 | 1.77663381 |
| 27 | TESK2 | 1.74231829 |
| 28 | BCKDK | 1.74037851 |
| 29 | EIF2AK3 | 1.63562936 |
| 30 | MUSK | 1.60635075 |
| 31 | WEE1 | 1.57507315 |
| 32 | ADRBK2 | 1.57048240 |
| 33 | PBK | 1.56328582 |
| 34 | SRPK1 | 1.49599682 |
| 35 | BRAF | 1.45233058 |
| 36 | BMPR1B | 1.44609175 |
| 37 | INSRR | 1.32660583 |
| 38 | MAP2K7 | 1.30015101 |
| 39 | PRPF4B | 1.29877059 |
| 40 | CDC7 | 1.25204912 |
| 41 | PLK4 | 1.22171003 |
| 42 | TESK1 | 1.22140246 |
| 43 | TXK | 1.20160296 |
| 44 | ACVR1B | 1.16845272 |
| 45 | TNIK | 1.16287794 |
| 46 | MAPK13 | 1.14317137 |
| 47 | CCNB1 | 1.14103953 |
| 48 | NTRK2 | 1.12419954 |
| 49 | TAOK3 | 1.12382779 |
| 50 | GRK7 | 1.07193000 |
| 51 | GRK5 | 1.04064430 |
| 52 | OXSR1 | 1.01898465 |
| 53 | MKNK1 | 1.01722535 |
| 54 | AKT3 | 1.01515676 |
| 55 | PHKG2 | 1.01013763 |
| 56 | PHKG1 | 1.01013763 |
| 57 | PAK3 | 1.00992382 |
| 58 | IRAK4 | 0.99984373 |
| 59 | CDK8 | 0.97050111 |
| 60 | IRAK1 | 0.94406642 |
| 61 | MYLK | 0.94405505 |
| 62 | PLK2 | 0.93664142 |
| 63 | CSNK1G3 | 0.93028318 |
| 64 | ERBB3 | 0.91792490 |
| 65 | TLK1 | 0.90569274 |
| 66 | MINK1 | 0.90128195 |
| 67 | NTRK3 | 0.85903043 |
| 68 | YES1 | 0.85181780 |
| 69 | PNCK | 0.81268786 |
| 70 | BRSK2 | 0.80260958 |
| 71 | EPHA3 | 0.79248720 |
| 72 | AURKA | 0.79072238 |
| 73 | DYRK3 | 0.78876328 |
| 74 | PLK3 | 0.77685203 |
| 75 | PIK3CA | 0.75662638 |
| 76 | MAPKAPK5 | 0.71461942 |
| 77 | DAPK1 | 0.70796615 |
| 78 | MAP3K11 | 0.70580351 |
| 79 | EPHB2 | 0.70268633 |
| 80 | STK39 | 0.68356510 |
| 81 | ADRBK1 | 0.68001991 |
| 82 | PDK2 | 0.67568292 |
| 83 | MATK | 0.66448844 |
| 84 | RPS6KA5 | 0.66073894 |
| 85 | ABL2 | 0.62537406 |
| 86 | CSNK1A1L | 0.62482948 |
| 87 | CLK1 | 0.60362119 |
| 88 | BRSK1 | 0.60018481 |
| 89 | CDK14 | 0.57397598 |
| 90 | BMPR2 | 0.57284115 |
| 91 | WNK3 | 0.56231811 |
| 92 | MAP2K6 | 0.56094982 |
| 93 | CDK18 | 0.55896870 |
| 94 | EPHB1 | 0.55640563 |
| 95 | CSNK2A1 | 0.55214120 |
| 96 | ATR | 0.53767858 |
| 97 | UHMK1 | 0.53441417 |
| 98 | CAMK2B | 0.52404732 |
| 99 | KDR | 0.51126325 |
| 100 | CAMKK2 | 0.50982509 |
| 101 | ZAK | 0.50327913 |
| 102 | EIF2AK2 | 0.49286723 |
| 103 | CSNK1A1 | 0.48602668 |
| 104 | MAP3K9 | 0.47614990 |
| 105 | CSNK1G2 | 0.47174219 |
| 106 | PRKACA | 0.46826111 |
| 107 | MKNK2 | 0.45614310 |
| 108 | PLK1 | 0.44835070 |
| 109 | TIE1 | 0.44631253 |
| 110 | PASK | 0.44523250 |
| 111 | CSNK1E | 0.44497471 |
| 112 | PRKCQ | 0.44041528 |
| 113 | CDK15 | 0.43425269 |
| 114 | MAP2K4 | 0.42363656 |
| 115 | CSNK1G1 | 0.41576845 |
| 116 | PRKCG | 0.41403485 |
| 117 | CDK11A | 0.41264306 |
| 118 | MAPKAPK3 | 0.41092907 |
| 119 | PAK1 | 0.40762119 |
| 120 | SYK | 0.40337188 |
| 121 | BLK | 0.39097980 |
| 122 | PINK1 | 0.39063260 |
| 123 | CSNK2A2 | 0.38804863 |
| 124 | DAPK2 | 0.38625969 |
| 125 | CAMK2D | 0.38305748 |
| 126 | EPHA4 | 0.38150354 |
| 127 | CHEK2 | 0.37690342 |
| 128 | PRKCE | 0.36637618 |
| 129 | CAMK1 | 0.36573393 |
| 130 | NLK | 0.36554169 |
| 131 | MAPK4 | 0.34871230 |
| 132 | CAMK2G | 0.34388941 |
| 133 | PRKCI | 0.32931271 |
| 134 | PRKCD | 0.30781549 |
| 135 | NEK1 | 0.29256345 |
| 136 | KIT | 0.26048492 |
| 137 | CAMK2A | 0.25378301 |
| 138 | LYN | 0.25156799 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.52612408 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.25775333 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.85189591 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.74846909 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.65511781 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 2.71467986 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.67618411 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.46032659 |
| 9 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.25476172 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.14700355 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.08639593 |
| 12 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.08064608 |
| 13 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.05376108 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 1.88700319 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.82031774 |
| 16 | DNA replication_Homo sapiens_hsa03030 | 1.75668991 |
| 17 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.52703991 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.51730382 |
| 19 | Mismatch repair_Homo sapiens_hsa03430 | 1.51273942 |
| 20 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.49109353 |
| 21 | Homologous recombination_Homo sapiens_hsa03440 | 1.48602503 |
| 22 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.45279311 |
| 23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.41322294 |
| 24 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.40919825 |
| 25 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.39661041 |
| 26 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.38793739 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.35007139 |
| 28 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.34092717 |
| 29 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.31345549 |
| 30 | RNA transport_Homo sapiens_hsa03013 | 1.31300147 |
| 31 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.30601669 |
| 32 | Allograft rejection_Homo sapiens_hsa05330 | 1.27888478 |
| 33 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.27823340 |
| 34 | Base excision repair_Homo sapiens_hsa03410 | 1.27151265 |
| 35 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.23730645 |
| 36 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.23687218 |
| 37 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.17440020 |
| 38 | Peroxisome_Homo sapiens_hsa04146 | 1.16321484 |
| 39 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.16021789 |
| 40 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.15834694 |
| 41 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.12533608 |
| 42 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.12239439 |
| 43 | Phagosome_Homo sapiens_hsa04145 | 1.11530841 |
| 44 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.04812525 |
| 45 | RNA degradation_Homo sapiens_hsa03018 | 1.03071719 |
| 46 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.02807642 |
| 47 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.01611559 |
| 48 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.01329813 |
| 49 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.98527574 |
| 50 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.98337004 |
| 51 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.98173628 |
| 52 | Asthma_Homo sapiens_hsa05310 | 0.97086515 |
| 53 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.96265897 |
| 54 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.96257572 |
| 55 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.95235172 |
| 56 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.94410093 |
| 57 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94178299 |
| 58 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.92011807 |
| 59 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.89013628 |
| 60 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.87154910 |
| 61 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.82371034 |
| 62 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.81863213 |
| 63 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.77367757 |
| 64 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.76602504 |
| 65 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.74882446 |
| 66 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.73319522 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.72813833 |
| 68 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.70123116 |
| 69 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.69332434 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.65714493 |
| 71 | Cell cycle_Homo sapiens_hsa04110 | 0.64793433 |
| 72 | Retinol metabolism_Homo sapiens_hsa00830 | 0.63574938 |
| 73 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.62105137 |
| 74 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.61749614 |
| 75 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.61629043 |
| 76 | Morphine addiction_Homo sapiens_hsa05032 | 0.61155843 |
| 77 | GABAergic synapse_Homo sapiens_hsa04727 | 0.60778362 |
| 78 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.59913781 |
| 79 | Metabolic pathways_Homo sapiens_hsa01100 | 0.59467191 |
| 80 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57840137 |
| 81 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.56971730 |
| 82 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.55486355 |
| 83 | Insulin secretion_Homo sapiens_hsa04911 | 0.55210740 |
| 84 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.54537429 |
| 85 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54504481 |
| 86 | Phototransduction_Homo sapiens_hsa04744 | 0.53994499 |
| 87 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.52921935 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.51591821 |
| 89 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.50361187 |
| 90 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.50195274 |
| 91 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.48970988 |
| 92 | Nicotine addiction_Homo sapiens_hsa05033 | 0.48379354 |
| 93 | Mineral absorption_Homo sapiens_hsa04978 | 0.48200192 |
| 94 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.45837005 |
| 95 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.44849029 |
| 96 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44581561 |
| 97 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.44233049 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.42908009 |
| 99 | Shigellosis_Homo sapiens_hsa05131 | 0.42353509 |
| 100 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.41316346 |
| 101 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.39898792 |
| 102 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.39028731 |
| 103 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.38500638 |
| 104 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.38225424 |
| 105 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.36727785 |
| 106 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.35997810 |
| 107 | Cocaine addiction_Homo sapiens_hsa05030 | 0.35287979 |
| 108 | Salmonella infection_Homo sapiens_hsa05132 | 0.34568334 |
| 109 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.33054419 |
| 110 | Circadian entrainment_Homo sapiens_hsa04713 | 0.32027456 |
| 111 | Pertussis_Homo sapiens_hsa05133 | 0.31412800 |
| 112 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.31002046 |
| 113 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.29933008 |
| 114 | Measles_Homo sapiens_hsa05162 | 0.28989738 |
| 115 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.28901302 |
| 116 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.28769266 |
| 117 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.28674041 |
| 118 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.28286861 |
| 119 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.28124022 |
| 120 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.27522733 |
| 121 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.27340320 |
| 122 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.26845132 |
| 123 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.26796109 |
| 124 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.26119861 |
| 125 | Axon guidance_Homo sapiens_hsa04360 | 0.25801284 |
| 126 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.25640926 |
| 127 | Sulfur relay system_Homo sapiens_hsa04122 | 0.24541874 |
| 128 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.24087552 |
| 129 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.21839793 |
| 130 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.20858669 |
| 131 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.20593110 |
| 132 | Olfactory transduction_Homo sapiens_hsa04740 | 0.20485483 |
| 133 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.20100522 |
| 134 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.18800662 |
| 135 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.18311899 |
| 136 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.17368654 |
| 137 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.16943736 |
| 138 | Alcoholism_Homo sapiens_hsa05034 | 0.15968580 |
| 139 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.14193459 |
| 140 | Leishmaniasis_Homo sapiens_hsa05140 | 0.12959197 |
| 141 | Lysosome_Homo sapiens_hsa04142 | 0.11091649 |
| 142 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.10933079 |
| 143 | Taste transduction_Homo sapiens_hsa04742 | 0.10849239 |
| 144 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.10146172 |

