TRAPPC6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.45620440
2positive regulation of dendritic spine morphogenesis (GO:0061003)4.14398130
3synaptic vesicle exocytosis (GO:0016079)4.09233542
4gamma-aminobutyric acid transport (GO:0015812)4.05367558
5regulation of synaptic vesicle exocytosis (GO:2000300)4.02163041
6protein maturation by protein folding (GO:0022417)3.93821348
7neuronal action potential propagation (GO:0019227)3.85119554
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81431072
9maturation of 5.8S rRNA (GO:0000460)3.78630448
10nucleobase catabolic process (GO:0046113)3.77668759
11regulation of synaptic vesicle transport (GO:1902803)3.69040437
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.64276162
13negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.63563993
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62832400
15synaptic vesicle maturation (GO:0016188)3.61226623
16organelle transport along microtubule (GO:0072384)3.58313227
17melanosome localization (GO:0032400)3.57613936
18protein K11-linked deubiquitination (GO:0035871)3.57404140
19establishment of mitochondrion localization (GO:0051654)3.55640819
20detection of calcium ion (GO:0005513)3.53045840
21glycerophospholipid catabolic process (GO:0046475)3.47004688
22glutamate secretion (GO:0014047)3.46778269
23chaperone-mediated protein transport (GO:0072321)3.46635271
24signal peptide processing (GO:0006465)3.45952929
25positive regulation of uterine smooth muscle contraction (GO:0070474)3.45225501
26vesicle docking (GO:0048278)3.41868005
27pigment granule localization (GO:0051875)3.39623739
28neuron cell-cell adhesion (GO:0007158)3.39235810
29adaptation of signaling pathway (GO:0023058)3.32193017
30positive regulation of vesicle fusion (GO:0031340)3.28993104
31protein import into peroxisome matrix (GO:0016558)3.28907684
32presynaptic membrane assembly (GO:0097105)3.25238253
33cerebellar Purkinje cell differentiation (GO:0021702)3.23039476
34neurotransmitter-gated ion channel clustering (GO:0072578)3.21774688
35nucleotide transmembrane transport (GO:1901679)3.21553703
36regulation of type B pancreatic cell apoptotic process (GO:2000674)3.20639569
37presynaptic membrane organization (GO:0097090)3.20236679
38vesicle docking involved in exocytosis (GO:0006904)3.19640897
39tachykinin receptor signaling pathway (GO:0007217)3.18827891
40membrane docking (GO:0022406)3.18440308
41C4-dicarboxylate transport (GO:0015740)3.18128628
42negative regulation of protein oligomerization (GO:0032460)3.17157800
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10016171
44Golgi transport vesicle coating (GO:0048200)3.09936504
45COPI coating of Golgi vesicle (GO:0048205)3.09936504
46regulation of dendritic spine morphogenesis (GO:0061001)3.08793372
47regulation of vesicle fusion (GO:0031338)3.04228202
48adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01266732
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.01165981
50protein-cofactor linkage (GO:0018065)3.00672987
51neurofilament cytoskeleton organization (GO:0060052)2.99846259
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99157183
53response to histamine (GO:0034776)2.98366256
54microtubule anchoring (GO:0034453)2.95974879
55proline transport (GO:0015824)2.94712636
56neural tube formation (GO:0001841)2.94166552
57magnesium ion transport (GO:0015693)2.93554128
58protein retention in ER lumen (GO:0006621)2.92287275
59regulation of feeding behavior (GO:0060259)2.92213385
60neurotransmitter secretion (GO:0007269)2.91597861
61ATP hydrolysis coupled proton transport (GO:0015991)2.88387776
62energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.88387776
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87368492
64protein localization to synapse (GO:0035418)2.85146181
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83064366
66protein targeting to lysosome (GO:0006622)2.82947482
67establishment of protein localization to vacuole (GO:0072666)2.82947482
68protein targeting to vacuole (GO:0006623)2.82947482
69negative regulation of dendrite morphogenesis (GO:0050774)2.80803417
70ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.80709624
71cellular zinc ion homeostasis (GO:0006882)2.79820106
72neuromuscular process controlling posture (GO:0050884)2.79268479
73zinc ion homeostasis (GO:0055069)2.79268192
74vesicle localization (GO:0051648)2.78983430
75ER overload response (GO:0006983)2.78258284
76DNA double-strand break processing (GO:0000729)2.77881422
77positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77845262
78regulation of oxidative phosphorylation (GO:0002082)2.77738620
79insulin secretion (GO:0030073)2.75974435
80ionotropic glutamate receptor signaling pathway (GO:0035235)2.75814229
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75360687
82negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.75098194
83negative regulation of calcium ion transmembrane transport (GO:1903170)2.75098194
84positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.73876648
85negative regulation of cation channel activity (GO:2001258)2.73860759
86lysosome localization (GO:0032418)2.73593628
87regulation of meiosis I (GO:0060631)2.73458391
88regulation of synapse structural plasticity (GO:0051823)2.71335441
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71323427
90establishment of melanosome localization (GO:0032401)2.69640189
91regulation of energy homeostasis (GO:2000505)2.69291648
92respiratory electron transport chain (GO:0022904)2.66610910
93electron transport chain (GO:0022900)2.65373130
94actin filament depolymerization (GO:0030042)2.65252181
95mitochondrion transport along microtubule (GO:0047497)2.64341834
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64341834
97glutamate receptor signaling pathway (GO:0007215)2.64077753
98peptide hormone processing (GO:0016486)2.64046688
99glycosphingolipid biosynthetic process (GO:0006688)2.64022303
100regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.63745537
101regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.63745537
102regulation of cofactor metabolic process (GO:0051193)2.63562057
103regulation of coenzyme metabolic process (GO:0051196)2.63562057
104transferrin transport (GO:0033572)2.62098598
105dopamine biosynthetic process (GO:0042416)2.61423773
106membrane depolarization during action potential (GO:0086010)2.61351695
107calcium-mediated signaling using intracellular calcium source (GO:0035584)2.61286275
108neuron-neuron synaptic transmission (GO:0007270)2.60958229
109regulation of neurotransmitter levels (GO:0001505)2.60898163
110regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60653891
111synapse assembly (GO:0007416)2.60223632
112regulation of acyl-CoA biosynthetic process (GO:0050812)2.60070915
113positive regulation of dendritic spine development (GO:0060999)2.59678226
114regulation of glutamate receptor signaling pathway (GO:1900449)2.59622899
115positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.59043770
116mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.59043770
117regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.58991449
118vocalization behavior (GO:0071625)2.58214320
119protein targeting to peroxisome (GO:0006625)2.58138923
120establishment of protein localization to peroxisome (GO:0072663)2.58138923
121protein localization to peroxisome (GO:0072662)2.58138923
122positive regulation of amino acid transport (GO:0051957)2.57899802
123establishment of protein localization to Golgi (GO:0072600)2.57659732
124vesicle transport along microtubule (GO:0047496)2.54214358
125microtubule-based transport (GO:0010970)2.54196718
126establishment of pigment granule localization (GO:0051905)2.53910572
127synaptic transmission, dopaminergic (GO:0001963)2.53602827
128positive regulation of insulin secretion (GO:0032024)2.53174679
129prepulse inhibition (GO:0060134)2.53106087
130gamma-aminobutyric acid signaling pathway (GO:0007214)2.52543644
131protein targeting to Golgi (GO:0000042)2.51706672
132innervation (GO:0060384)2.51348958
133ferric iron transport (GO:0015682)2.50988626
134trivalent inorganic cation transport (GO:0072512)2.50988626
135activation of protein kinase A activity (GO:0034199)2.50655628
136negative regulation of neurotransmitter transport (GO:0051589)2.50547857
137negative regulation of mast cell activation (GO:0033004)2.49733265
138transmission of nerve impulse (GO:0019226)2.49273717
139energy coupled proton transport, down electrochemical gradient (GO:0015985)2.49127589
140ATP synthesis coupled proton transport (GO:0015986)2.49127589
141monoubiquitinated protein deubiquitination (GO:0035520)2.49052570
142regulation of long-term neuronal synaptic plasticity (GO:0048169)2.48329618
143regulation of dendritic spine development (GO:0060998)2.48270462
144positive regulation of exocytosis (GO:0045921)2.47705687
145regulation of amino acid transport (GO:0051955)2.47307906
146regulation of amyloid precursor protein catabolic process (GO:1902991)2.47107036
147positive regulation of neurotransmitter secretion (GO:0001956)2.46882263
148negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46835472
149postsynaptic membrane organization (GO:0001941)2.45585638
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.45349318
151regulation of neurotransmitter secretion (GO:0046928)2.43938980
152protein localization to cilium (GO:0061512)2.43937253
153oligosaccharide biosynthetic process (GO:0009312)2.43918430
154regulation of insulin secretion (GO:0050796)2.43780695
155inner mitochondrial membrane organization (GO:0007007)2.43184458
156cellular response to glucagon stimulus (GO:0071377)2.41649901
157regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.40056300
158regulation of glutamate secretion (GO:0014048)2.39854278
159synaptic transmission, glutamatergic (GO:0035249)2.39755564
160positive regulation of neurotransmitter transport (GO:0051590)2.39246145
161protein complex biogenesis (GO:0070271)2.39180572
162melanosome transport (GO:0032402)2.39119849
163regulation of neuron projection regeneration (GO:0070570)2.38869945
164regulation of axon regeneration (GO:0048679)2.38869945
165neurotransmitter transport (GO:0006836)2.38657790
166regulation of protein kinase A signaling (GO:0010738)2.38207705
167negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.38146336
168regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.36716548
169signal release (GO:0023061)2.35204357
170response to amphetamine (GO:0001975)2.35132068
171synaptic vesicle docking involved in exocytosis (GO:0016081)2.33946611
172serotonin receptor signaling pathway (GO:0007210)2.32702864
173regulation of neuronal synaptic plasticity (GO:0048168)2.32565963
174regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.32488239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41092519
2GBX2_23144817_ChIP-Seq_PC3_Human3.04860905
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83458653
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81284615
5TAF15_26573619_Chip-Seq_HEK293_Human2.74655727
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66580527
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64118833
8IGF1R_20145208_ChIP-Seq_DFB_Human2.57746933
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55300880
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46472607
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.36092351
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35041374
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33167158
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27882101
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.26353928
16REST_21632747_ChIP-Seq_MESCs_Mouse2.25369480
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22560227
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20426487
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20109785
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18970774
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12897197
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.09699822
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05653412
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03153561
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03153561
26P300_19829295_ChIP-Seq_ESCs_Human1.95382357
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94940850
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94086250
29NR3C1_23031785_ChIP-Seq_PC12_Mouse1.92220389
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89577797
31IRF1_19129219_ChIP-ChIP_H3396_Human1.88665258
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84527781
33ZNF274_21170338_ChIP-Seq_K562_Hela1.84178052
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83160632
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.79953356
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78088954
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.77137371
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.76286530
39VDR_22108803_ChIP-Seq_LS180_Human1.74768823
40ER_23166858_ChIP-Seq_MCF-7_Human1.74434005
41EWS_26573619_Chip-Seq_HEK293_Human1.73812746
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72993346
43SMAD4_21799915_ChIP-Seq_A2780_Human1.70740465
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.69688671
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62223779
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61585736
47TCF4_23295773_ChIP-Seq_U87_Human1.57900716
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.55389901
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54587931
50AR_25329375_ChIP-Seq_VCAP_Human1.50711631
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45876001
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45132258
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42661683
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40682636
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40679583
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.39515248
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.38564387
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.37745124
59AR_21572438_ChIP-Seq_LNCaP_Human1.37507483
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.37310930
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36934210
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36760019
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.32394177
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32078008
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.28751771
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28579545
67* TAL1_26923725_Chip-Seq_HPCs_Mouse1.26635115
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25409209
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25245957
70BCAT_22108803_ChIP-Seq_LS180_Human1.24791329
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.23847103
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23776936
73P300_18555785_Chip-Seq_ESCs_Mouse1.23173551
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21597593
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21184198
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19904014
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19451198
78JUN_21703547_ChIP-Seq_K562_Human1.18794269
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18624717
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.18477249
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.18025628
82TP53_16413492_ChIP-PET_HCT116_Human1.16240503
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14411228
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13824772
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.13674699
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13503497
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13227561
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11015867
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11015867
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.10839506
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.09082788
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08995961
93FUS_26573619_Chip-Seq_HEK293_Human1.08836520
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.08780122
95GATA1_22025678_ChIP-Seq_K562_Human1.08107080
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.07693102
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.07597141
98TP53_18474530_ChIP-ChIP_U2OS_Human1.06041062
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06022273
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06005337
101RUNX2_22187159_ChIP-Seq_PCA_Human1.05676505
102REST_19997604_ChIP-ChIP_NEURONS_Mouse1.04838168
103BP1_19119308_ChIP-ChIP_Hs578T_Human1.04546756
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03400540
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.02744397
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02669652
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.02022199
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00735708
109CBP_20019798_ChIP-Seq_JUKART_Human0.99955049
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99955049
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98055025
112RNF2_27304074_Chip-Seq_NSC_Mouse0.97610425
113TCF4_22108803_ChIP-Seq_LS180_Human0.97110009
114P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96420872
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95025832
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94880663
117KDM2B_26808549_Chip-Seq_REH_Human0.94667146
118TP53_22573176_ChIP-Seq_HFKS_Human0.93188033
119NANOG_19829295_ChIP-Seq_ESCs_Human0.92726998
120SOX2_19829295_ChIP-Seq_ESCs_Human0.92726998
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92375259
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90204468
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89773337
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.89342888
125DROSHA_22980978_ChIP-Seq_HELA_Human0.89302628
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88985397
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.87473791
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87338432
129STAT3_23295773_ChIP-Seq_U87_Human0.84814243
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84673842
131P53_22387025_ChIP-Seq_ESCs_Mouse0.82369277
132HTT_18923047_ChIP-ChIP_STHdh_Human0.80921429
133ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80005157
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79549412
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79325877
136SOX2_20726797_ChIP-Seq_SW620_Human0.79111669
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78282581
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.77865833
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77743907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.98757330
2MP0004859_abnormal_synaptic_plasticity3.27822705
3MP0006276_abnormal_autonomic_nervous3.16915689
4MP0000569_abnormal_digit_pigmentation3.04844419
5MP0010386_abnormal_urinary_bladder2.88778806
6MP0002837_dystrophic_cardiac_calcinosis2.84911805
7MP0002909_abnormal_adrenal_gland2.80979639
8MP0001968_abnormal_touch/_nociception2.78741295
9MP0003635_abnormal_synaptic_transmissio2.75456908
10MP0000013_abnormal_adipose_tissue2.74125724
11MP0002735_abnormal_chemical_nociception2.67769583
12MP0004270_analgesia2.64212496
13MP0003787_abnormal_imprinting2.52943835
14MP0002734_abnormal_mechanical_nocicepti2.45840322
15MP0002254_reproductive_system_inflammat2.43823371
16MP0005379_endocrine/exocrine_gland_phen2.35718281
17MP0009745_abnormal_behavioral_response2.34212945
18MP0009780_abnormal_chondrocyte_physiolo2.29821564
19MP0008877_abnormal_DNA_methylation2.26470798
20MP0009046_muscle_twitch2.24283236
21MP0002733_abnormal_thermal_nociception2.20620723
22MP0001501_abnormal_sleep_pattern2.17400815
23MP0002736_abnormal_nociception_after2.17201740
24MP0001984_abnormal_olfaction2.17154097
25MP0002063_abnormal_learning/memory/cond2.16778837
26MP0004147_increased_porphyrin_level2.13499988
27MP0002064_seizures2.09987935
28MP0001970_abnormal_pain_threshold2.09628692
29MP0005645_abnormal_hypothalamus_physiol2.08022329
30MP0002876_abnormal_thyroid_physiology2.03551679
31MP0002572_abnormal_emotion/affect_behav1.99212130
32MP0002638_abnormal_pupillary_reflex1.97744623
33MP0002272_abnormal_nervous_system1.90029243
34MP0005646_abnormal_pituitary_gland1.88261298
35MP0005075_abnormal_melanosome_morpholog1.86546149
36MP0003121_genomic_imprinting1.81940205
37MP0003183_abnormal_peptide_metabolism1.79117827
38MP0002693_abnormal_pancreas_physiology1.78850694
39MP0003890_abnormal_embryonic-extraembry1.75732450
40MP0003195_calcinosis1.75685004
41MP0004885_abnormal_endolymph1.73002525
42MP0002163_abnormal_gland_morphology1.65144515
43MP0005535_abnormal_body_temperature1.63354906
44MP0003122_maternal_imprinting1.62738331
45MP0001440_abnormal_grooming_behavior1.58686264
46MP0002877_abnormal_melanocyte_morpholog1.56697014
47MP0001905_abnormal_dopamine_level1.56594049
48MP0002067_abnormal_sensory_capabilities1.51023226
49MP0001944_abnormal_pancreas_morphology1.50763418
50MP0004043_abnormal_pH_regulation1.50466801
51MP0002184_abnormal_innervation1.48239780
52MP0001986_abnormal_taste_sensitivity1.47931664
53MP0004924_abnormal_behavior1.38453929
54MP0005386_behavior/neurological_phenoty1.38453929
55MP0005408_hypopigmentation1.37572611
56MP0000778_abnormal_nervous_system1.35828508
57MP0006082_CNS_inflammation1.34184094
58MP0001502_abnormal_circadian_rhythm1.33976225
59MP0001486_abnormal_startle_reflex1.32973090
60MP0001188_hyperpigmentation1.31850785
61MP0003329_amyloid_beta_deposits1.27261308
62MP0003879_abnormal_hair_cell1.24805086
63MP0002822_catalepsy1.24323837
64MP0002557_abnormal_social/conspecific_i1.23486823
65MP0005187_abnormal_penis_morphology1.22056031
66MP0006072_abnormal_retinal_apoptosis1.19381243
67MP0000372_irregular_coat_pigmentation1.16132547
68MP0001529_abnormal_vocalization1.14225058
69MP0000015_abnormal_ear_pigmentation1.13683224
70MP0005167_abnormal_blood-brain_barrier1.12881434
71MP0002078_abnormal_glucose_homeostasis1.12408525
72MP0002229_neurodegeneration1.12174435
73MP0004858_abnormal_nervous_system1.11479762
74MP0003690_abnormal_glial_cell1.10248469
75MP0004742_abnormal_vestibular_system1.09791496
76MP0003283_abnormal_digestive_organ1.07724772
77MP0008569_lethality_at_weaning1.05568608
78MP0005084_abnormal_gallbladder_morpholo1.05545358
79MP0000538_abnormal_urinary_bladder1.04114891
80MP0010329_abnormal_lipoprotein_level1.03933511
81MP0005253_abnormal_eye_physiology1.01669379
82MP0004142_abnormal_muscle_tone1.01556010
83MP0005499_abnormal_olfactory_system1.00662429
84MP0005394_taste/olfaction_phenotype1.00662429
85MP0004484_altered_response_of1.00606241
86MP0000230_abnormal_systemic_arterial1.00436349
87MP0004215_abnormal_myocardial_fiber0.99946162
88MP0000681_abnormal_thyroid_gland0.99371721
89MP0001919_abnormal_reproductive_system0.98120646
90MP0000631_abnormal_neuroendocrine_gland0.97278798
91MP0002332_abnormal_exercise_endurance0.96509395
92MP0003633_abnormal_nervous_system0.95285763
93MP0006036_abnormal_mitochondrial_physio0.94021995
94MP0000003_abnormal_adipose_tissue0.93490937
95MP0005389_reproductive_system_phenotype0.93255593
96MP0004811_abnormal_neuron_physiology0.93146234
97MP0001664_abnormal_digestion0.92277034
98MP0002090_abnormal_vision0.92136397
99MP0006292_abnormal_olfactory_placode0.91681057
100MP0004782_abnormal_surfactant_physiolog0.91410702
101MP0005220_abnormal_exocrine_pancreas0.90069190
102MP0002102_abnormal_ear_morphology0.88126847
103MP0001177_atelectasis0.88008006
104MP0002160_abnormal_reproductive_system0.87963327
105MP0004145_abnormal_muscle_electrophysio0.87608890
106MP0000639_abnormal_adrenal_gland0.87181331
107MP0002069_abnormal_eating/drinking_beha0.85594835
108MP0003631_nervous_system_phenotype0.85511896
109MP0009697_abnormal_copulation0.85394933
110MP0005448_abnormal_energy_balance0.84910142
111MP0004510_myositis0.84175278
112MP0003698_abnormal_male_reproductive0.83880316
113MP0008872_abnormal_physiological_respon0.83641052
114MP0003646_muscle_fatigue0.83316849
115MP0002066_abnormal_motor_capabilities/c0.83018302
116MP0005636_abnormal_mineral_homeostasis0.82996026
117MP0002751_abnormal_autonomic_nervous0.82885769
118MP0001765_abnormal_ion_homeostasis0.82834429
119MP0008995_early_reproductive_senescence0.82199184
120MP0002752_abnormal_somatic_nervous0.80833363
121MP0002132_abnormal_respiratory_system0.80735705
122MP0005174_abnormal_tail_pigmentation0.79892160
123MP0005551_abnormal_eye_electrophysiolog0.79540201
124MP0003221_abnormal_cardiomyocyte_apopto0.79122592
125MP0002234_abnormal_pharynx_morphology0.78691717
126MP0001270_distended_abdomen0.78533810
127MP0003953_abnormal_hormone_level0.76864213
128MP0000678_abnormal_parathyroid_gland0.76123183
129MP0004130_abnormal_muscle_cell0.74972146
130MP0003724_increased_susceptibility_to0.73859198
131MP0000955_abnormal_spinal_cord0.71807386
132MP0003172_abnormal_lysosome_physiology0.70998646
133MP0002882_abnormal_neuron_morphology0.70280524
134MP0003959_abnormal_lean_body0.70031237
135MP0003656_abnormal_erythrocyte_physiolo0.69361057
136MP0004085_abnormal_heartbeat0.67742622
137MP0005423_abnormal_somatic_nervous0.67059523
138MP0001756_abnormal_urination0.66803014
139MP0000604_amyloidosis0.64769088
140MP0005595_abnormal_vascular_smooth0.59599630
141MP0008874_decreased_physiological_sensi0.59588884
142MP0006035_abnormal_mitochondrial_morpho0.59518624

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.55105674
2Hypothermia (HP:0002045)4.41918964
3Visual hallucinations (HP:0002367)3.85877985
4Atonic seizures (HP:0010819)3.66456547
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.63977515
6Papilledema (HP:0001085)3.44795316
7Abnormal mitochondria in muscle tissue (HP:0008316)3.39428587
8Acute necrotizing encephalopathy (HP:0006965)3.36519466
9Agitation (HP:0000713)3.33245568
10Epileptic encephalopathy (HP:0200134)3.31909817
11Pheochromocytoma (HP:0002666)3.26379411
12Hip dysplasia (HP:0001385)3.25844204
13Neuroendocrine neoplasm (HP:0100634)3.15859396
14Abnormality of B cell number (HP:0010975)3.14888228
15Oligodactyly (hands) (HP:0001180)3.13381379
16Absence seizures (HP:0002121)3.07992758
17Myokymia (HP:0002411)3.00561410
18Abnormality of the corticospinal tract (HP:0002492)3.00445260
19Fibular aplasia (HP:0002990)2.99112577
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.97858736
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.97858736
22Focal seizures (HP:0007359)2.92287561
23Limb dystonia (HP:0002451)2.91540257
24Progressive macrocephaly (HP:0004481)2.91503114
25Febrile seizures (HP:0002373)2.90690166
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89324145
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89324145
28Amyotrophic lateral sclerosis (HP:0007354)2.84537782
29Mitochondrial inheritance (HP:0001427)2.82293452
30Drooling (HP:0002307)2.81986963
31Retinal dysplasia (HP:0007973)2.81235493
32Hypoglycemic seizures (HP:0002173)2.80259205
33Acute encephalopathy (HP:0006846)2.80022366
34Progressive cerebellar ataxia (HP:0002073)2.77858605
35Impaired vibration sensation in the lower limbs (HP:0002166)2.76552224
36Anxiety (HP:0000739)2.70693793
37Generalized tonic-clonic seizures (HP:0002069)2.70384603
38Oligomenorrhea (HP:0000876)2.69335108
39Hyperventilation (HP:0002883)2.68571037
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.63241361
41Menstrual irregularities (HP:0000858)2.62324973
42Lissencephaly (HP:0001339)2.61602860
43Failure to thrive in infancy (HP:0001531)2.56013711
44Urinary urgency (HP:0000012)2.54585214
45Symptomatic seizures (HP:0011145)2.54490740
46Dialeptic seizures (HP:0011146)2.52929259
47Excessive salivation (HP:0003781)2.52627108
48Papillary thyroid carcinoma (HP:0002895)2.48432096
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44031707
50Abnormality of alanine metabolism (HP:0010916)2.44031707
51Hyperalaninemia (HP:0003348)2.44031707
52Type II lissencephaly (HP:0007260)2.42912122
53Urinary bladder sphincter dysfunction (HP:0002839)2.42514480
54Absent speech (HP:0001344)2.42066493
55Polyphagia (HP:0002591)2.37773560
56Hepatic necrosis (HP:0002605)2.36808629
57B lymphocytopenia (HP:0010976)2.34981762
58Gait imbalance (HP:0002141)2.33106139
59Hepatocellular necrosis (HP:0001404)2.32943803
60Hepatoblastoma (HP:0002884)2.31865592
61Increased CSF lactate (HP:0002490)2.31146737
62Fair hair (HP:0002286)2.31117754
63Mucopolysacchariduria (HP:0008155)2.31045482
64Urinary glycosaminoglycan excretion (HP:0003541)2.31045482
65Dysostosis multiplex (HP:0000943)2.29009536
66Abnormality of the labia minora (HP:0012880)2.27888802
67Medial flaring of the eyebrow (HP:0010747)2.27840762
68Progressive inability to walk (HP:0002505)2.27200345
69Spastic gait (HP:0002064)2.26621856
70Congenital primary aphakia (HP:0007707)2.25935786
71Decreased circulating renin level (HP:0003351)2.21654415
72Split foot (HP:0001839)2.20811449
73Hyperthyroidism (HP:0000836)2.19850165
74Gonadotropin excess (HP:0000837)2.18442212
75Depression (HP:0000716)2.17921730
76Thyroid-stimulating hormone excess (HP:0002925)2.17735504
77Spastic tetraplegia (HP:0002510)2.16953304
78Hypoglycemic coma (HP:0001325)2.16210158
79Hyperinsulinemic hypoglycemia (HP:0000825)2.15754414
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.15606212
81Autoamputation (HP:0001218)2.15481183
82Nephrogenic diabetes insipidus (HP:0009806)2.15110747
83Thyroid carcinoma (HP:0002890)2.14911509
84Ketoacidosis (HP:0001993)2.14362374
85Mutism (HP:0002300)2.12877010
86Growth hormone excess (HP:0000845)2.12746954
87Central scotoma (HP:0000603)2.10871010
88Epileptiform EEG discharges (HP:0011182)2.10224957
89Broad-based gait (HP:0002136)2.09223919
90Generalized aminoaciduria (HP:0002909)2.09100339
91Increased muscle lipid content (HP:0009058)2.08554067
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08306000
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08306000
94Abnormality of polysaccharide metabolism (HP:0011012)2.08306000
95Hypercortisolism (HP:0001578)2.06787350
96Volvulus (HP:0002580)2.05925385
97Short tibia (HP:0005736)2.03525533
98Hypoplastic iliac wings (HP:0002866)2.03255851
99Amblyopia (HP:0000646)2.02644222
100EEG with generalized epileptiform discharges (HP:0011198)2.02428288
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02037608
102Abnormal eating behavior (HP:0100738)2.01980903
103Increased intramyocellular lipid droplets (HP:0012240)2.01763075
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99360151
105Abnormal protein N-linked glycosylation (HP:0012347)1.99360151
106Abnormal protein glycosylation (HP:0012346)1.99360151
107Abnormal glycosylation (HP:0012345)1.99360151
108Abnormality of the vocal cords (HP:0008777)1.99295562
109Lower limb muscle weakness (HP:0007340)1.98173621
110Dysautonomia (HP:0002459)1.94061722
111Inability to walk (HP:0002540)1.93676089
112Abnormal hair whorl (HP:0010721)1.93160045
113Impaired social interactions (HP:0000735)1.93105872
114Abnormal social behavior (HP:0012433)1.93105872
115Beaking of vertebral bodies (HP:0004568)1.92958450
116Neoplasm of the adrenal gland (HP:0100631)1.92859561
117Acanthocytosis (HP:0001927)1.92110881
118Truncal ataxia (HP:0002078)1.91961429
119Pachygyria (HP:0001302)1.91513619
120Type I transferrin isoform profile (HP:0003642)1.91332762
121Abnormality of the renal cortex (HP:0011035)1.90560377
122Morphological abnormality of the pyramidal tract (HP:0002062)1.89151463
123Cerebral hemorrhage (HP:0001342)1.88156588
124Supranuclear gaze palsy (HP:0000605)1.87255604
125Aplasia/hypoplasia of the uterus (HP:0008684)1.86799952
126Lactic acidosis (HP:0003128)1.86338280
127Adactyly (HP:0009776)1.85957635
128Muscular hypotonia of the trunk (HP:0008936)1.85726364
129Insulin-resistant diabetes mellitus (HP:0000831)1.85687702
130Restlessness (HP:0000711)1.85311946
131Generalized hypopigmentation of hair (HP:0011358)1.85267934
132Hypsarrhythmia (HP:0002521)1.84539702
133Paraplegia (HP:0010550)1.84203230
134Decreased muscle mass (HP:0003199)1.83680853
135Thoracolumbar scoliosis (HP:0002944)1.82710789
136Cerebral hypomyelination (HP:0006808)1.79597414
137Protruding tongue (HP:0010808)1.79491414
138Poor suck (HP:0002033)1.79288124
139Short foot (HP:0001773)1.78767910
140Oligodactyly (HP:0012165)1.78639145
141Gaze-evoked nystagmus (HP:0000640)1.78352731
142Impaired vibratory sensation (HP:0002495)1.78007110
143Arthropathy (HP:0003040)1.77552598
144Termporal pattern (HP:0011008)1.75936494
145Insidious onset (HP:0003587)1.75936494
146Broad alveolar ridges (HP:0000187)1.75913911
147Intention tremor (HP:0002080)1.75455334
148Ankle clonus (HP:0011448)1.75058879
149Conjugated hyperbilirubinemia (HP:0002908)1.74989614
150Action tremor (HP:0002345)1.74723531
151Abnormality of the lower motor neuron (HP:0002366)1.74308474
152CNS demyelination (HP:0007305)1.73965048
153Renal cortical cysts (HP:0000803)1.73869908
154Tubulointerstitial nephritis (HP:0001970)1.73111778
155Delusions (HP:0000746)1.72968473
156Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72777160
157Abnormality of macular pigmentation (HP:0008002)1.72213340
158CNS hypomyelination (HP:0003429)1.72075842
159Optic disc pallor (HP:0000543)1.71869128
160Exercise intolerance (HP:0003546)1.70842598
161Poor eye contact (HP:0000817)1.70122648
162Palpitations (HP:0001962)1.69627303
163Hyperactive renin-angiotensin system (HP:0000841)1.69611733
164Psychosis (HP:0000709)1.68470777
165X-linked dominant inheritance (HP:0001423)1.67999363
166Hypokinesia (HP:0002375)1.67652796
167Brushfield spots (HP:0001088)1.66813933
168Testicular neoplasm (HP:0010788)1.66586369
169Focal dystonia (HP:0004373)1.66019400
170Abnormality of binocular vision (HP:0011514)1.65004043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.00969545
2NTRK33.57177760
3BCR3.21087626
4RIPK43.15569905
5MAP4K23.01491799
6TRIM282.54501342
7MAP2K72.42886898
8ARAF2.40636069
9CAMKK22.37146471
10WNK32.20659071
11CSNK1G12.19838991
12MINK12.15005042
13MAP3K132.06657524
14CASK2.02391803
15INSRR2.01097175
16CSNK1G21.98300140
17MAP3K21.97207840
18SIK31.96503543
19MAP3K91.95166286
20FRK1.88190283
21GRK51.86492572
22MAP3K41.79889066
23CSNK1A1L1.79043671
24CSNK1G31.78489420
25BMPR21.76301122
26MAP2K41.74288305
27EPHA41.62408838
28NME11.59273575
29NTRK11.57555227
30KSR21.49077154
31BMPR1B1.34071970
32MAP3K31.30229675
33PLK21.29873015
34TAOK21.25805203
35STK391.24080260
36LATS11.23304317
37TNIK1.23073178
38SCYL21.21840611
39ACVR1B1.21815251
40ERBB31.20425678
41BLK1.20337780
42DAPK21.18758923
43SIK21.18721923
44DAPK11.17306633
45MAP3K111.15071267
46PIM21.13254326
47NUAK11.13184561
48AKT31.07234543
49MAP3K11.06672419
50MAPK151.05509060
51PTK2B1.05368586
52EPHA31.05265224
53CDK51.03773239
54GRK71.02056537
55MUSK1.01818657
56ADRBK21.00822484
57HIPK20.98937635
58MAPK130.97280618
59MARK10.95405729
60CAMKK10.94683129
61OXSR10.93835169
62PRKCE0.93817656
63STK38L0.93347903
64EIF2AK10.92428874
65PRPF4B0.91129754
66CDK190.89637957
67PAK30.88188134
68NME20.87202387
69DYRK30.85313806
70BRAF0.85305298
71RAF10.85111657
72CAMK2A0.84445908
73PRKCI0.82105009
74KIT0.82071478
75SGK20.81329775
76SYK0.80206711
77PAK60.79392047
78MAP2K10.78924195
79ERN10.76297281
80PRKCG0.75042466
81PRKG20.73524870
82MYLK0.72942062
83MAP3K50.71360373
84KSR10.70314508
85MAPKAPK50.69997964
86BCKDK0.69642943
87SGK30.69415570
88PINK10.69373748
89UHMK10.68716104
90FES0.68544055
91CCNB10.68030433
92IRAK20.67021264
93NLK0.66163706
94PRKD30.66111155
95GRK10.65563476
96FGFR10.65407394
97FER0.65401269
98IRAK10.65157862
99ADRBK10.65100620
100MAP3K60.63943868
101PRKCH0.62383821
102CDK80.62334256
103TNK20.61404526
104FLT30.61234714
105PIK3CA0.59716176
106MAPKAPK30.57114779
107DYRK20.56871472
108CAMK10.54730426
109DYRK1A0.54553017
110PHKG10.53453726
111PHKG20.53453726
112TEC0.53351645
113LATS20.52785647
114BRD40.52208127
115PASK0.49411853
116CSNK1D0.48157311
117CAMK2D0.48101153
118RPS6KA40.47676635
119MKNK20.47667457
120LIMK10.47533799
121CAMK2B0.47219451
122PRKCZ0.47006946
123SGK10.46980747
124PRKD20.46419638
125CDK140.45400594
126DYRK1B0.45337432
127CSNK1E0.45182643
128FGFR30.44990928
129WNK40.44946629
130RET0.44687836
131CSNK1A10.43815781
132PRKACA0.42905147
133SGK2230.42762785
134SGK4940.42762785
135SRPK10.42294119
136FGR0.41560207
137EIF2AK30.41554179
138NTRK20.40725338
139RPS6KA20.40320316
140JAK30.39302578
141TAOK30.39205593
142TIE10.38674547
143MOS0.37251125
144MAP2K60.36169475
145CAMK40.34358553
146CDK180.34019948
147STK30.33720365
148WNK10.33150728
149PRKG10.33086772
150FGFR20.32131992

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.29897816
2Nicotine addiction_Homo sapiens_hsa050333.05179241
3Synaptic vesicle cycle_Homo sapiens_hsa047212.89788531
4Oxidative phosphorylation_Homo sapiens_hsa001902.66047949
5Collecting duct acid secretion_Homo sapiens_hsa049662.25267851
6Butanoate metabolism_Homo sapiens_hsa006502.24662913
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.23639745
8Parkinsons disease_Homo sapiens_hsa050122.20766551
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19822926
10Insulin secretion_Homo sapiens_hsa049112.18939144
11GABAergic synapse_Homo sapiens_hsa047272.16674516
12Vibrio cholerae infection_Homo sapiens_hsa051102.10737383
13Circadian entrainment_Homo sapiens_hsa047132.08772629
14Amphetamine addiction_Homo sapiens_hsa050312.08646051
15Long-term potentiation_Homo sapiens_hsa047202.04902911
16Steroid biosynthesis_Homo sapiens_hsa001002.02530465
17Alzheimers disease_Homo sapiens_hsa050101.99270340
18Dopaminergic synapse_Homo sapiens_hsa047281.91619454
19Morphine addiction_Homo sapiens_hsa050321.89572694
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81264760
21Taste transduction_Homo sapiens_hsa047421.80955949
22Olfactory transduction_Homo sapiens_hsa047401.80917946
23Serotonergic synapse_Homo sapiens_hsa047261.80122094
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78255144
25Cocaine addiction_Homo sapiens_hsa050301.71335610
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71070036
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70865926
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70403542
29Basal transcription factors_Homo sapiens_hsa030221.63457498
30Glutamatergic synapse_Homo sapiens_hsa047241.61202155
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58441321
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56998040
33Renin secretion_Homo sapiens_hsa049241.52134659
34Type I diabetes mellitus_Homo sapiens_hsa049401.44402736
35Propanoate metabolism_Homo sapiens_hsa006401.42146961
36Cardiac muscle contraction_Homo sapiens_hsa042601.41120353
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39516631
38Long-term depression_Homo sapiens_hsa047301.35918065
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34994500
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34610313
41Cholinergic synapse_Homo sapiens_hsa047251.34006878
42Selenocompound metabolism_Homo sapiens_hsa004501.33470942
43Salivary secretion_Homo sapiens_hsa049701.32431678
44Huntingtons disease_Homo sapiens_hsa050161.29631986
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25270611
46Sulfur metabolism_Homo sapiens_hsa009201.23418849
47Peroxisome_Homo sapiens_hsa041461.23131903
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22098422
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19750829
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17853781
51Regulation of autophagy_Homo sapiens_hsa041401.16299734
52Calcium signaling pathway_Homo sapiens_hsa040201.12126204
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09616096
54Ether lipid metabolism_Homo sapiens_hsa005651.08271123
55Dorso-ventral axis formation_Homo sapiens_hsa043201.08001255
56Rheumatoid arthritis_Homo sapiens_hsa053231.05473245
57Oxytocin signaling pathway_Homo sapiens_hsa049211.01508898
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99328576
59Gastric acid secretion_Homo sapiens_hsa049710.97414185
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95150966
61Axon guidance_Homo sapiens_hsa043600.94507146
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93898217
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92807012
64N-Glycan biosynthesis_Homo sapiens_hsa005100.91686062
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90100147
66Gap junction_Homo sapiens_hsa045400.87517276
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86333623
68Phagosome_Homo sapiens_hsa041450.85830560
69GnRH signaling pathway_Homo sapiens_hsa049120.85555248
70Pancreatic secretion_Homo sapiens_hsa049720.85072687
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84830418
72cAMP signaling pathway_Homo sapiens_hsa040240.82524040
73Fatty acid elongation_Homo sapiens_hsa000620.82171938
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81095725
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80068783
76Nitrogen metabolism_Homo sapiens_hsa009100.79190540
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79168636
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77074645
79RNA degradation_Homo sapiens_hsa030180.76655187
80Phototransduction_Homo sapiens_hsa047440.75239504
81Prion diseases_Homo sapiens_hsa050200.75130744
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.73377868
83Linoleic acid metabolism_Homo sapiens_hsa005910.73333499
84Thyroid hormone synthesis_Homo sapiens_hsa049180.72988417
85Type II diabetes mellitus_Homo sapiens_hsa049300.71937422
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71656392
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.70069266
88Lysosome_Homo sapiens_hsa041420.69779185
89Caffeine metabolism_Homo sapiens_hsa002320.69627237
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67050447
91African trypanosomiasis_Homo sapiens_hsa051430.66810143
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62563902
93beta-Alanine metabolism_Homo sapiens_hsa004100.61904806
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61282258
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.59680884
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58090652
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57947413
98Estrogen signaling pathway_Homo sapiens_hsa049150.57236725
99Arginine and proline metabolism_Homo sapiens_hsa003300.55863617
100Fanconi anemia pathway_Homo sapiens_hsa034600.55482626
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53618954
102Fatty acid metabolism_Homo sapiens_hsa012120.52080770
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51346685
104Circadian rhythm_Homo sapiens_hsa047100.50553458
105ABC transporters_Homo sapiens_hsa020100.50453230
106Tuberculosis_Homo sapiens_hsa051520.48849072
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.47647533
108Glucagon signaling pathway_Homo sapiens_hsa049220.46711257
109Fatty acid biosynthesis_Homo sapiens_hsa000610.46038350
110Galactose metabolism_Homo sapiens_hsa000520.45914874
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45318415
112Glycerolipid metabolism_Homo sapiens_hsa005610.44971813
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44965896
114Thyroid cancer_Homo sapiens_hsa052160.44393992
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43916879
116Sphingolipid metabolism_Homo sapiens_hsa006000.43059536
117Melanogenesis_Homo sapiens_hsa049160.42598040
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39710950
119Glioma_Homo sapiens_hsa052140.38862212
120Retinol metabolism_Homo sapiens_hsa008300.36898519
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36502987
122Insulin signaling pathway_Homo sapiens_hsa049100.35058813
123Complement and coagulation cascades_Homo sapiens_hsa046100.32142700
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31410185
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30856374
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30640459
127Metabolic pathways_Homo sapiens_hsa011000.29966625
128Alcoholism_Homo sapiens_hsa050340.29955582
129MAPK signaling pathway_Homo sapiens_hsa040100.29096720
130Prolactin signaling pathway_Homo sapiens_hsa049170.27664692
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.26916356
132Hippo signaling pathway_Homo sapiens_hsa043900.26390684
133Other glycan degradation_Homo sapiens_hsa005110.25492054
134VEGF signaling pathway_Homo sapiens_hsa043700.24142831
135ErbB signaling pathway_Homo sapiens_hsa040120.23777573
136Ras signaling pathway_Homo sapiens_hsa040140.22906588
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22671162
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21263458
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20928496
140Choline metabolism in cancer_Homo sapiens_hsa052310.20389735
141Oocyte meiosis_Homo sapiens_hsa041140.20208169
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.19785092
143Starch and sucrose metabolism_Homo sapiens_hsa005000.19733560
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19570405
145Dilated cardiomyopathy_Homo sapiens_hsa054140.18262570

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