TRAPPC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)9.67014912
2piRNA metabolic process (GO:0034587)7.84877098
3male meiosis I (GO:0007141)7.45767506
4chromosome organization involved in meiosis (GO:0070192)7.43660437
5DNA synthesis involved in DNA repair (GO:0000731)7.04407313
6histone H3-K36 demethylation (GO:0070544)6.91568107
7regulation of meiosis I (GO:0060631)6.85428365
8sister chromatid cohesion (GO:0007062)6.69233704
9DNA methylation involved in gamete generation (GO:0043046)6.39795858
10male meiosis (GO:0007140)6.38943702
11synaptonemal complex assembly (GO:0007130)6.25952459
12synaptonemal complex organization (GO:0070193)5.62349323
13histone H3-K9 demethylation (GO:0033169)5.60187800
14meiosis I (GO:0007127)5.53726065
15meiotic nuclear division (GO:0007126)5.46311168
16gene silencing by RNA (GO:0031047)4.62468963
17meiotic cell cycle process (GO:1903046)4.57430637
18pore complex assembly (GO:0046931)4.50456037
19regulation of histone H3-K9 methylation (GO:0051570)4.47599491
20establishment of nucleus localization (GO:0040023)4.27261485
21regulation of DNA endoreduplication (GO:0032875)4.19895480
22meiotic chromosome segregation (GO:0045132)4.04219822
23reciprocal DNA recombination (GO:0035825)4.00933427
24reciprocal meiotic recombination (GO:0007131)4.00933427
25genitalia morphogenesis (GO:0035112)4.00060204
26histone lysine demethylation (GO:0070076)3.98915906
27dicarboxylic acid biosynthetic process (GO:0043650)3.95122843
28resolution of meiotic recombination intermediates (GO:0000712)3.93206846
29interkinetic nuclear migration (GO:0022027)3.88421039
30alpha-linolenic acid metabolic process (GO:0036109)3.81730311
31negative regulation of cell killing (GO:0031342)3.79707572
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.79707572
33histone demethylation (GO:0016577)3.77803384
34nucleus localization (GO:0051647)3.77666044
35cytoplasmic mRNA processing body assembly (GO:0033962)3.77311767
36protein localization to endosome (GO:0036010)3.65956759
37phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.64009143
38cellular response to ethanol (GO:0071361)3.61141201
39positive regulation of meiosis (GO:0045836)3.56472988
40urea cycle (GO:0000050)3.54420655
41urea metabolic process (GO:0019627)3.54420655
42regulation of protein polyubiquitination (GO:1902914)3.51927537
43negative regulation of DNA repair (GO:0045738)3.45715761
44positive regulation of meiotic cell cycle (GO:0051446)3.43033116
45growth hormone receptor signaling pathway (GO:0060396)3.41926923
46nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.39694168
47phospholipid homeostasis (GO:0055091)3.37109252
48lipoprotein transport (GO:0042953)3.35930856
49regulation of chromatin silencing (GO:0031935)3.30726833
50regulation of RNA export from nucleus (GO:0046831)3.28696220
51Golgi to endosome transport (GO:0006895)3.28300075
52low-density lipoprotein particle clearance (GO:0034383)3.26468475
53female gamete generation (GO:0007292)3.25762495
54protein demethylation (GO:0006482)3.25376107
55protein dealkylation (GO:0008214)3.25376107
56negative regulation of inclusion body assembly (GO:0090084)3.21800513
57triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21095927
58regulation of cholesterol homeostasis (GO:2000188)3.19154518
59protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.17255130
60regulation of NFAT protein import into nucleus (GO:0051532)3.16799528
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13853427
62regulation of nucleobase-containing compound transport (GO:0032239)3.08313149
63nuclear pore complex assembly (GO:0051292)3.06179899
64regulation of fatty acid beta-oxidation (GO:0031998)3.05965209
65regulation of centriole replication (GO:0046599)3.05222803
66cysteine metabolic process (GO:0006534)3.05154823
67negative regulation of meiosis (GO:0045835)3.04229549
68negative regulation of gene silencing (GO:0060969)3.04090533
69nitrogen cycle metabolic process (GO:0071941)3.01300695
70plasma lipoprotein particle clearance (GO:0034381)2.98612514
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97134064
72L-phenylalanine catabolic process (GO:0006559)2.97134064
73gene silencing (GO:0016458)2.94505304
74negative regulation of DNA-dependent DNA replication (GO:2000104)2.94423922
75homocysteine metabolic process (GO:0050667)2.91793608
76complement activation, alternative pathway (GO:0006957)2.90411689
77histone H4-K16 acetylation (GO:0043984)2.89962236
78cellular response to growth hormone stimulus (GO:0071378)2.88105961
79negative regulation of fibrinolysis (GO:0051918)2.87999774
80regulation of cholesterol storage (GO:0010885)2.87810145
81microtubule anchoring (GO:0034453)2.87714451
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.86820504
83lysine metabolic process (GO:0006553)2.83508284
84lysine catabolic process (GO:0006554)2.83508284
85oogenesis (GO:0048477)2.82802504
86positive regulation of histone deacetylation (GO:0031065)2.80855677
87peptidyl-lysine trimethylation (GO:0018023)2.79317974
88kynurenine metabolic process (GO:0070189)2.79034715
89nuclear pore organization (GO:0006999)2.78973639
90regulation of protein activation cascade (GO:2000257)2.78461917
91macroautophagy (GO:0016236)2.78142291
92histone H2A acetylation (GO:0043968)2.77839202
93somite rostral/caudal axis specification (GO:0032525)2.74441062
94regulation of clathrin-mediated endocytosis (GO:2000369)2.73919033
95peptidyl-threonine phosphorylation (GO:0018107)2.73915212
96peptidyl-glutamic acid carboxylation (GO:0017187)2.73822981
97protein carboxylation (GO:0018214)2.73822981
98gonadal mesoderm development (GO:0007506)2.73497475
99neural tube formation (GO:0001841)2.73127720
100regulation of meiotic cell cycle (GO:0051445)2.72180376
101DNA alkylation (GO:0006305)2.71730746
102DNA methylation (GO:0006306)2.71730746
103meiotic cell cycle (GO:0051321)2.71542811
104attachment of spindle microtubules to kinetochore (GO:0008608)2.70642306
105regulation of triglyceride catabolic process (GO:0010896)2.70358243
106aromatic amino acid family catabolic process (GO:0009074)2.69339139
107positive regulation of lipid catabolic process (GO:0050996)2.69229784
108acrosome assembly (GO:0001675)2.69118138
109mitotic chromosome condensation (GO:0007076)2.68695025
110erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.67940519
111L-phenylalanine metabolic process (GO:0006558)2.67940519
112peptidyl-threonine modification (GO:0018210)2.67779013
113protein localization to chromosome (GO:0034502)2.67172646
114bile acid biosynthetic process (GO:0006699)2.66856302
115fatty acid transmembrane transport (GO:1902001)2.65987844
116acetyl-CoA metabolic process (GO:0006084)2.65851474
117corticosteroid receptor signaling pathway (GO:0031958)2.65005800
118regulation of complement activation (GO:0030449)2.64920017
119glutamate metabolic process (GO:0006536)2.63148433
120regulation of sister chromatid cohesion (GO:0007063)2.61357741
121centriole replication (GO:0007099)2.59710986
122protein targeting to Golgi (GO:0000042)2.58874463
123positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.58465635
124protein-lipid complex assembly (GO:0065005)2.58335076
125NLS-bearing protein import into nucleus (GO:0006607)2.57859102
126peptidyl-lysine dimethylation (GO:0018027)2.54343099
127establishment of protein localization to Golgi (GO:0072600)2.54245038
128high-density lipoprotein particle remodeling (GO:0034375)2.53757883
129cholesterol efflux (GO:0033344)2.53260319
130reverse cholesterol transport (GO:0043691)2.51696150
131regulation of fibrinolysis (GO:0051917)2.51638112
132early endosome to late endosome transport (GO:0045022)2.51387105
133bile acid metabolic process (GO:0008206)2.51072163
134positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.50889092
135positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.50889092
136positive regulation of mitotic sister chromatid separation (GO:1901970)2.50889092
137serine family amino acid catabolic process (GO:0009071)2.50768632
138chromosome organization (GO:0051276)2.49871508
139monoubiquitinated protein deubiquitination (GO:0035520)2.49419952
140regulation of protein glycosylation (GO:0060049)2.49377751
141histone mRNA catabolic process (GO:0071044)2.48793551
142positive regulation of gamma-delta T cell activation (GO:0046645)2.48409487
143nucleus organization (GO:0006997)2.46124914
144phospholipid efflux (GO:0033700)2.45527914
1452-oxoglutarate metabolic process (GO:0006103)2.45348350
146pericardium development (GO:0060039)2.44947357
147protein K11-linked deubiquitination (GO:0035871)2.44930369
148fatty acid homeostasis (GO:0055089)2.44900681
149regulation of centrosome duplication (GO:0010824)2.44372305
150intracellular lipid transport (GO:0032365)2.44180412
151plasma lipoprotein particle assembly (GO:0034377)2.42865603
152mitotic sister chromatid cohesion (GO:0007064)2.42833410
153cell adhesion mediated by integrin (GO:0033627)2.42679702
154negative regulation of sterol transport (GO:0032372)2.42549611
155negative regulation of cholesterol transport (GO:0032375)2.42549611
156regulation of gamma-delta T cell differentiation (GO:0045586)2.42155878
157triglyceride homeostasis (GO:0070328)2.41740632
158acylglycerol homeostasis (GO:0055090)2.41740632
159embryonic foregut morphogenesis (GO:0048617)2.41462460
160cilium or flagellum-dependent cell motility (GO:0001539)2.41082557
161indole-containing compound catabolic process (GO:0042436)2.40167218
162indolalkylamine catabolic process (GO:0046218)2.40167218
163tryptophan catabolic process (GO:0006569)2.40167218
164positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38480992
165ethanol oxidation (GO:0006069)2.37910140
166negative regulation of fatty acid biosynthetic process (GO:0045717)2.37028485
167lipoprotein metabolic process (GO:0042157)2.36657478
168regulation of meiosis (GO:0040020)2.36647223
169antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.35088336
170DNA-dependent DNA replication (GO:0006261)2.34465018
171histone H3-K9 methylation (GO:0051567)2.33953869
172retrograde transport, vesicle recycling within Golgi (GO:0000301)2.30511072
173sulfur amino acid catabolic process (GO:0000098)2.30263886
174carnitine shuttle (GO:0006853)2.29675465
175response to growth hormone (GO:0060416)2.28877085
176amino-acid betaine metabolic process (GO:0006577)2.28412644
177glucocorticoid receptor signaling pathway (GO:0042921)2.27660407
178cortical actin cytoskeleton organization (GO:0030866)2.26552878
179insulin-like growth factor receptor signaling pathway (GO:0048009)2.26413738
180sterol homeostasis (GO:0055092)2.26234657
181epithelial cell differentiation involved in prostate gland development (GO:0060742)2.25976985
182tryptophan metabolic process (GO:0006568)2.24324932
183lipid translocation (GO:0034204)2.22342356
184phospholipid translocation (GO:0045332)2.22342356
185regulation of B cell receptor signaling pathway (GO:0050855)2.21374120
186macromolecular complex remodeling (GO:0034367)2.20893956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.12528004
2E2F7_22180533_ChIP-Seq_HELA_Human4.00923300
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.88947441
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.19414234
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.19038396
6POU3F2_20337985_ChIP-ChIP_501MEL_Human3.12612802
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.04610293
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02629559
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47264910
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.47178954
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.38243050
12CLOCK_20551151_ChIP-Seq_293T_Human2.35735933
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33305954
14GATA1_22025678_ChIP-Seq_K562_Human2.26873913
15TAF15_26573619_Chip-Seq_HEK293_Human2.21150912
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.17313172
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.14836371
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10208471
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09328162
20FUS_26573619_Chip-Seq_HEK293_Human2.07570276
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07318295
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.03323430
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93534440
24* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93061021
25IGF1R_20145208_ChIP-Seq_DFB_Human1.92865257
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.88983766
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85675019
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.80044189
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.78817934
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78753102
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76624527
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75954761
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.74941842
34ZNF263_19887448_ChIP-Seq_K562_Human1.74689384
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74523000
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71929353
37STAT3_23295773_ChIP-Seq_U87_Human1.64272058
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63432920
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62804427
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60075028
41EWS_26573619_Chip-Seq_HEK293_Human1.59579169
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56638934
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55578399
44RUNX_20019798_ChIP-Seq_JUKART_Human1.55415647
45ER_23166858_ChIP-Seq_MCF-7_Human1.54938016
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.52486577
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.52090320
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51295640
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50775388
50TP53_16413492_ChIP-PET_HCT116_Human1.50502362
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49509461
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48169099
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46356044
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46112075
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.44806832
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44004713
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43742823
58KDM2B_26808549_Chip-Seq_DND41_Human1.43309943
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41134078
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40929555
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40754956
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38953619
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38936406
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.38318505
65BCAT_22108803_ChIP-Seq_LS180_Human1.37898616
66TCF7_22412390_ChIP-Seq_EML_Mouse1.37788867
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36925099
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36631437
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36606120
70TCF4_23295773_ChIP-Seq_U87_Human1.36561321
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36320625
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34496431
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34239512
74GBX2_23144817_ChIP-Seq_PC3_Human1.34071440
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33707439
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29421068
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29219177
78SMAD4_21799915_ChIP-Seq_A2780_Human1.29151240
79P300_19829295_ChIP-Seq_ESCs_Human1.28630733
80MYC_22102868_ChIP-Seq_BL_Human1.28144870
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26951626
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26686074
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.26442003
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.26250179
85ZNF274_21170338_ChIP-Seq_K562_Hela1.25522141
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24441147
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.24258574
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23812624
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21531604
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.19693439
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19689045
92GATA1_19941826_ChIP-Seq_K562_Human1.19673355
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19339508
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19127192
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19024325
96CDX2_22108803_ChIP-Seq_LS180_Human1.17894930
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.16151501
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.15866567
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15758299
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15104503
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13784775
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13752961
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12817516
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12086295
105GATA2_19941826_ChIP-Seq_K562_Human1.10661126
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.10604774
107GATA6_25053715_ChIP-Seq_YYC3_Human1.10408729
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.09349365
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08345658
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08053661
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06562902
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06543577
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06266136
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.05749581
115TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05122176
116SPI1_23127762_ChIP-Seq_K562_Human1.04862749
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04845037
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04763576
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04231418
120E2F1_21310950_ChIP-Seq_MCF-7_Human1.03841819
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03189404
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02901766
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02766835
124CBP_20019798_ChIP-Seq_JUKART_Human1.02693211
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02693211
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02616645
127AHR_22903824_ChIP-Seq_MCF-7_Human1.02531669
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01931297
129MYB_26560356_Chip-Seq_TH1_Human1.01271533
130HNF4A_19822575_ChIP-Seq_HepG2_Human1.01129172
131NOTCH1_21737748_ChIP-Seq_TLL_Human1.01082037
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.01016904
133RUNX2_22187159_ChIP-Seq_PCA_Human1.00957116
134ESR1_20079471_ChIP-ChIP_T-47D_Human1.00949402
135TP63_23658742_ChIP-Seq_EP156T_Human1.00655102
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00538881
137SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00141843
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99983352
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99691714
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99645260
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99586857
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99004702
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98997779
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98744360
145P300_18555785_Chip-Seq_ESCs_Mouse0.98452108
146VDR_22108803_ChIP-Seq_LS180_Human0.98138846
147AR_25329375_ChIP-Seq_VCAP_Human0.97987094
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.97962279
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97729759
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97661604
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97465327
152SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97403141
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97143153
154ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95909842
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95883228
156MYB_26560356_Chip-Seq_TH2_Human0.95831415
157PU_27001747_Chip-Seq_BMDM_Mouse0.94827268
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94742623
159KDM2B_26808549_Chip-Seq_JURKAT_Human0.94592569
160VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93892865
161GATA3_27048872_Chip-Seq_THYMUS_Human0.93176397
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92608848
163NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92608848
164MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92219529
165BRD4_25478319_ChIP-Seq_HGPS_Human0.91409801
166RXR_22108803_ChIP-Seq_LS180_Human0.90631380
167RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90164877
168ARNT_22903824_ChIP-Seq_MCF-7_Human0.89860107
169FOXA1_25552417_ChIP-Seq_VCAP_Human0.89215575
170SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89143030
171SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89143030
172E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88487947
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88308043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.38529571
2MP0008877_abnormal_DNA_methylation5.32961411
3MP0005360_urolithiasis4.26665248
4MP0002139_abnormal_hepatobiliary_system4.01112837
5MP0003705_abnormal_hypodermis_morpholog3.75092328
6MP0010234_abnormal_vibrissa_follicle3.31208146
7MP0005085_abnormal_gallbladder_physiolo3.27258235
8MP0005365_abnormal_bile_salt3.21666151
9MP0003252_abnormal_bile_duct2.84327413
10MP0003890_abnormal_embryonic-extraembry2.83487816
11MP0000569_abnormal_digit_pigmentation2.66202260
12MP0003300_gastrointestinal_ulcer2.52377592
13MP0010352_gastrointestinal_tract_polyps2.49547464
14MP0009840_abnormal_foam_cell2.41600059
15MP0005174_abnormal_tail_pigmentation2.38155080
16MP0010094_abnormal_chromosome_stability2.34489441
17MP0002210_abnormal_sex_determination2.34184474
18MP0000604_amyloidosis2.29570357
19MP0001929_abnormal_gametogenesis2.28883224
20MP0008058_abnormal_DNA_repair2.27289824
21MP0010329_abnormal_lipoprotein_level2.26694666
22MP0008875_abnormal_xenobiotic_pharmacok2.10940081
23MP0004185_abnormal_adipocyte_glucose2.06398400
24MP0010307_abnormal_tumor_latency1.97732329
25MP0003329_amyloid_beta_deposits1.95427485
26MP0005083_abnormal_biliary_tract1.91990113
27MP0003191_abnormal_cellular_cholesterol1.90355334
28MP0003690_abnormal_glial_cell1.88841621
29MP0000015_abnormal_ear_pigmentation1.88562669
30MP0001145_abnormal_male_reproductive1.88493842
31MP0005409_darkened_coat_color1.88229574
32MP0008260_abnormal_autophagy1.86360431
33MP0003646_muscle_fatigue1.84455866
34MP0002396_abnormal_hematopoietic_system1.83873718
35MP0006054_spinal_hemorrhage1.82299276
36MP0003303_peritoneal_inflammation1.79893583
37MP0000609_abnormal_liver_physiology1.78717330
38MP0004808_abnormal_hematopoietic_stem1.77554052
39MP0005076_abnormal_cell_differentiation1.75862406
40MP0003698_abnormal_male_reproductive1.72739851
41MP0000653_abnormal_sex_gland1.69740055
42MP0002160_abnormal_reproductive_system1.68427428
43MP0004130_abnormal_muscle_cell1.68130772
44MP0001666_abnormal_nutrient_absorption1.66874753
45MP0005451_abnormal_body_composition1.65067501
46MP0003566_abnormal_cell_adhesion1.58267094
47MP0003763_abnormal_thymus_physiology1.52322471
48MP0004957_abnormal_blastocyst_morpholog1.52041060
49MP0003943_abnormal_hepatobiliary_system1.50433550
50MP0005666_abnormal_adipose_tissue1.44159613
51MP0002166_altered_tumor_susceptibility1.42006068
52MP0004947_skin_inflammation1.39991724
53MP0002118_abnormal_lipid_homeostasis1.39269724
54MP0003806_abnormal_nucleotide_metabolis1.38791094
55MP0001545_abnormal_hematopoietic_system1.38696054
56MP0005397_hematopoietic_system_phenotyp1.38696054
57MP0003045_fibrosis1.37121261
58MP0005167_abnormal_blood-brain_barrier1.37037548
59MP0003656_abnormal_erythrocyte_physiolo1.35683372
60MP0003787_abnormal_imprinting1.34829722
61MP0003221_abnormal_cardiomyocyte_apopto1.34052586
62MP0001915_intracranial_hemorrhage1.33291413
63MP0002138_abnormal_hepatobiliary_system1.31555855
64MP0002095_abnormal_skin_pigmentation1.30763134
65MP0003111_abnormal_nucleus_morphology1.30273045
66MP0010678_abnormal_skin_adnexa1.29933733
67MP0005310_abnormal_salivary_gland1.29888323
68MP0005332_abnormal_amino_acid1.29652596
69MP0003077_abnormal_cell_cycle1.29548110
70MP0003172_abnormal_lysosome_physiology1.28550306
71MP0009780_abnormal_chondrocyte_physiolo1.27427730
72MP0002084_abnormal_developmental_patter1.24148122
73MP0002254_reproductive_system_inflammat1.20566566
74MP0004019_abnormal_vitamin_homeostasis1.16294078
75MP0002088_abnormal_embryonic_growth/wei1.14505127
76MP0000465_gastrointestinal_hemorrhage1.13145424
77MP0005075_abnormal_melanosome_morpholog1.12440345
78MP0005058_abnormal_lysosome_morphology1.12246668
79MP0001119_abnormal_female_reproductive1.12228468
80MP0005375_adipose_tissue_phenotype1.11705415
81MP0003091_abnormal_cell_migration1.10994376
82MP0005380_embryogenesis_phenotype1.10813472
83MP0001672_abnormal_embryogenesis/_devel1.10813472
84MP0003984_embryonic_growth_retardation1.10288055
85MP0005389_reproductive_system_phenotype1.09704713
86MP0006082_CNS_inflammation1.08464282
87MP0004484_altered_response_of1.06785982
88MP0003693_abnormal_embryo_hatching1.04395577
89MP0001697_abnormal_embryo_size1.04298014
90MP0002971_abnormal_brown_adipose1.03189473
91MP0003183_abnormal_peptide_metabolism1.02307738
92MP0000371_diluted_coat_color0.99906019
93MP0005023_abnormal_wound_healing0.96405458
94MP0008961_abnormal_basal_metabolism0.95620293
95MP0000350_abnormal_cell_proliferation0.95491452
96MP0005319_abnormal_enzyme/_coenzyme0.94971632
97MP0000598_abnormal_liver_morphology0.94568743
98MP0000647_abnormal_sebaceous_gland0.93921529
99MP0003436_decreased_susceptibility_to0.93662094
100MP0002006_tumorigenesis0.93539821
101MP0003868_abnormal_feces_composition0.93197557
102MP0000703_abnormal_thymus_morphology0.89139200
103MP0003937_abnormal_limbs/digits/tail_de0.88796276
104MP0000003_abnormal_adipose_tissue0.88540529
105MP0003453_abnormal_keratinocyte_physiol0.88512584
106MP0002086_abnormal_extraembryonic_tissu0.87340775
107MP0001661_extended_life_span0.86512806
108MP0000733_abnormal_muscle_development0.85854077
109MP0008004_abnormal_stomach_pH0.84561442
110MP0005584_abnormal_enzyme/coenzyme_acti0.84301409
111MP0002998_abnormal_bone_remodeling0.82899561
112MP0000685_abnormal_immune_system0.82764566
113MP0003828_pulmonary_edema0.82720641
114MP0009278_abnormal_bone_marrow0.82381282
115MP0001851_eye_inflammation0.82014287
116MP0009703_decreased_birth_body0.81974706
117MP0004381_abnormal_hair_follicle0.81664971
118MP0005464_abnormal_platelet_physiology0.80747819
119MP0001800_abnormal_humoral_immune0.80546802
120MP0004264_abnormal_extraembryonic_tissu0.80407305
121MP0009763_increased_sensitivity_to0.80208807
122MP0005166_decreased_susceptibility_to0.79936116
123MP0003699_abnormal_female_reproductive0.79651479
124MP0002928_abnormal_bile_duct0.79600717
125MP0003632_abnormal_nervous_system0.79256955
126MP0009672_abnormal_birth_weight0.79058080
127MP0000372_irregular_coat_pigmentation0.78874075
128MP0001835_abnormal_antigen_presentation0.78675103
129MP0001881_abnormal_mammary_gland0.76136376
130MP0010368_abnormal_lymphatic_system0.74369399
131MP0002161_abnormal_fertility/fecundity0.74339923
132MP0005334_abnormal_fat_pad0.73861636
133MP0009643_abnormal_urine_homeostasis0.73052372
134MP0002877_abnormal_melanocyte_morpholog0.72928405
135MP0002136_abnormal_kidney_physiology0.72840617
136MP0002896_abnormal_bone_mineralization0.72593815
137MP0005623_abnormal_meninges_morphology0.72173016
138MP0002085_abnormal_embryonic_tissue0.71399491
139MP0002168_other_aberrant_phenotype0.71073268
140MP0003448_altered_tumor_morphology0.70986627
141MP0001191_abnormal_skin_condition0.69281685
142MP0004197_abnormal_fetal_growth/weight/0.68428651
143MP0003724_increased_susceptibility_to0.68067789
144MP0000427_abnormal_hair_cycle0.67809095
145MP0004510_myositis0.67172051
146MP0005248_abnormal_Harderian_gland0.66480527
147MP0005647_abnormal_sex_gland0.66165805
148MP0004233_abnormal_muscle_weight0.65915805
149MP0002419_abnormal_innate_immunity0.65500859
150MP0008007_abnormal_cellular_replicative0.65280509
151MP0001730_embryonic_growth_arrest0.65041388
152MP0005621_abnormal_cell_physiology0.64710084
153MP0009115_abnormal_fat_cell0.64687305
154MP0009384_cardiac_valve_regurgitation0.64150637
155MP0002009_preneoplasia0.63874911
156MP0003633_abnormal_nervous_system0.63789594
157MP0000249_abnormal_blood_vessel0.63766250
158MP0003195_calcinosis0.63300025
159MP0002080_prenatal_lethality0.62643389
160MP0005384_cellular_phenotype0.62597141
161MP0002398_abnormal_bone_marrow0.62267492
162MP0001845_abnormal_inflammatory_respons0.61749076
163MP0002452_abnormal_antigen_presenting0.61702065
164MP0008469_abnormal_protein_level0.61396262
165MP0006035_abnormal_mitochondrial_morpho0.61034390
166MP0000383_abnormal_hair_follicle0.60829840
167MP0005187_abnormal_penis_morphology0.59729909
168MP0002075_abnormal_coat/hair_pigmentati0.59354688
169MP0000490_abnormal_crypts_of0.58543162
170MP0002722_abnormal_immune_system0.58358032
171MP0002796_impaired_skin_barrier0.58149493
172MP0000689_abnormal_spleen_morphology0.58108963

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.48334512
2Papillary thyroid carcinoma (HP:0002895)3.94952270
3Gonadotropin excess (HP:0000837)3.93567556
4Deep venous thrombosis (HP:0002625)3.76574369
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.63679923
6Degeneration of the lateral corticospinal tracts (HP:0002314)3.63679923
7Myocardial infarction (HP:0001658)3.54637417
8Intrahepatic cholestasis (HP:0001406)3.47815717
9Absent frontal sinuses (HP:0002688)3.25385328
10Chromsome breakage (HP:0040012)3.24634481
11Xanthomatosis (HP:0000991)3.18812789
12Abnormality of the corticospinal tract (HP:0002492)3.05836648
13Acute myeloid leukemia (HP:0004808)3.02109471
14Rimmed vacuoles (HP:0003805)2.99409968
15Horizontal nystagmus (HP:0000666)2.95689602
16Neoplasm of the adrenal cortex (HP:0100641)2.94347782
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87683440
18Epidermoid cyst (HP:0200040)2.85471265
19Hematochezia (HP:0002573)2.85140233
20Abnormality of chromosome stability (HP:0003220)2.80167451
21Complement deficiency (HP:0004431)2.77830495
22Macroorchidism (HP:0000053)2.71814987
23Upper motor neuron abnormality (HP:0002127)2.70080497
24Abnormality of the lower motor neuron (HP:0002366)2.69940567
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69935912
26Shoulder girdle muscle weakness (HP:0003547)2.69394123
27Cerebral inclusion bodies (HP:0100314)2.66276534
28Nephroblastoma (Wilms tumor) (HP:0002667)2.64271882
29Disinhibition (HP:0000734)2.63791997
30Abnormality of chromosome segregation (HP:0002916)2.61571102
31Amyotrophic lateral sclerosis (HP:0007354)2.61319570
32Hypobetalipoproteinemia (HP:0003563)2.59900656
33Embryonal renal neoplasm (HP:0011794)2.52656317
34Spastic diplegia (HP:0001264)2.51974558
35Hypoplasia of the thymus (HP:0000778)2.48501345
36Menstrual irregularities (HP:0000858)2.45947414
37Esophageal varix (HP:0002040)2.45848154
38Peritonitis (HP:0002586)2.43452753
39Rhabdomyosarcoma (HP:0002859)2.41623094
40Hyperlipoproteinemia (HP:0010980)2.41114732
41Hypoalphalipoproteinemia (HP:0003233)2.40296940
42Hypoplastic labia majora (HP:0000059)2.40200480
43Heterotopia (HP:0002282)2.39989892
44Hypolipoproteinemia (HP:0010981)2.38141123
45Osteomalacia (HP:0002749)2.37803380
46Abnormal biliary tract morphology (HP:0012440)2.37760330
47Basal cell carcinoma (HP:0002671)2.36618621
48Hypercholesterolemia (HP:0003124)2.36329479
49Abnormal pancreas size (HP:0012094)2.36033749
50Biliary tract neoplasm (HP:0100574)2.35757667
51Abnormality of T cell number (HP:0011839)2.35224006
52Cortical dysplasia (HP:0002539)2.35001894
53Neurofibrillary tangles (HP:0002185)2.34733922
54Syringomyelia (HP:0003396)2.32182892
55Spinal cord lesions (HP:0100561)2.32182892
56Malignant gastrointestinal tract tumors (HP:0006749)2.31049848
57Gastrointestinal carcinoma (HP:0002672)2.31049848
58Capillary hemangiomas (HP:0005306)2.29356258
59Medulloblastoma (HP:0002885)2.28884896
60Thyroid carcinoma (HP:0002890)2.27334143
61Neoplasm of the small intestine (HP:0100833)2.26752897
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26467001
63Global brain atrophy (HP:0002283)2.24647012
64Abnormality of sulfur amino acid metabolism (HP:0004339)2.24265682
65Protruding tongue (HP:0010808)2.22366986
66Transitional cell carcinoma of the bladder (HP:0006740)2.21498072
67Fair hair (HP:0002286)2.18476034
68B lymphocytopenia (HP:0010976)2.17815021
69Cerebral aneurysm (HP:0004944)2.17533215
70Abnormality of the common coagulation pathway (HP:0010990)2.17443646
71Increased CSF protein (HP:0002922)2.17043956
72Azoospermia (HP:0000027)2.16828121
73Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16073574
74Neoplasm of the oral cavity (HP:0100649)2.15938669
75Insidious onset (HP:0003587)2.15139780
76Termporal pattern (HP:0011008)2.15139780
77Low anterior hairline (HP:0000294)2.14751802
78Abnormality of the labia majora (HP:0012881)2.12472250
79Tubulointerstitial nephritis (HP:0001970)2.11188382
80Impaired vibration sensation in the lower limbs (HP:0002166)2.11154018
81Spastic paraplegia (HP:0001258)2.10937029
82Recurrent gram-negative bacterial infections (HP:0005420)2.10634674
83Bladder neoplasm (HP:0009725)2.09770152
84Bladder carcinoma (HP:0002862)2.09770152
85Increased mean platelet volume (HP:0011877)2.08676517
86Subacute progressive viral hepatitis (HP:0006572)2.08449641
87Oligodactyly (hands) (HP:0001180)2.07249906
88Hepatocellular carcinoma (HP:0001402)2.05366900
89Spontaneous hematomas (HP:0007420)2.05202352
90Ectopic kidney (HP:0000086)2.04300616
91Abnormality of B cell number (HP:0010975)2.04009525
92Resting tremor (HP:0002322)2.03893060
93Recurrent bacterial skin infections (HP:0005406)2.01498535
94Neonatal hypoglycemia (HP:0001998)1.99278473
95Abnormality of complement system (HP:0005339)1.98537103
96Conjunctival telangiectasia (HP:0000524)1.96730661
97Mitral valve prolapse (HP:0001634)1.94870776
98Narrow palate (HP:0000189)1.94095012
99Sandal gap (HP:0001852)1.93511249
100Lower limb muscle weakness (HP:0007340)1.92846343
101Skin nodule (HP:0200036)1.92421564
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91476543
103Neoplasm of striated muscle (HP:0009728)1.90913297
104Metaphyseal dysplasia (HP:0100255)1.90381276
105Osteolytic defects of the phalanges of the hand (HP:0009771)1.90215887
106Osteolytic defects of the hand bones (HP:0009699)1.90215887
107Neoplasm of the colon (HP:0100273)1.90016109
108Fat malabsorption (HP:0002630)1.89834964
109Acanthocytosis (HP:0001927)1.89211117
110Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88510607
111Hyporeflexia of lower limbs (HP:0002600)1.88190952
112Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87898376
113Abnormality of the renal cortex (HP:0011035)1.87755663
114Spastic tetraparesis (HP:0001285)1.87385326
115Leiomyosarcoma (HP:0100243)1.87141402
116Uterine leiomyosarcoma (HP:0002891)1.87141402
117Colon cancer (HP:0003003)1.87048012
118Deep philtrum (HP:0002002)1.85688037
119Mitral stenosis (HP:0001718)1.85555767
120Chronic diarrhea (HP:0002028)1.85197051
121Cystic hygroma (HP:0000476)1.85152249
122Widely spaced teeth (HP:0000687)1.85023563
123Abnormal platelet volume (HP:0011876)1.84683109
124Back pain (HP:0003418)1.81632121
125Paraplegia (HP:0010550)1.81584729
126Spontaneous abortion (HP:0005268)1.81433189
127Hyperkalemia (HP:0002153)1.81242851
128Impaired vibratory sensation (HP:0002495)1.80869542
129Abnormality of lateral ventricle (HP:0030047)1.78794636
130Vertebral arch anomaly (HP:0008438)1.78011488
131Abnormal spermatogenesis (HP:0008669)1.77239196
132Enlarged penis (HP:0000040)1.76865572
133Spondylolisthesis (HP:0003302)1.76753312
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76656862
135Embryonal neoplasm (HP:0002898)1.76180272
136Increased nuchal translucency (HP:0010880)1.75381479
137Ulnar bowing (HP:0003031)1.75328298
138Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74913029
139Thyroiditis (HP:0100646)1.74140608
140Limb hypertonia (HP:0002509)1.73532369
14111 pairs of ribs (HP:0000878)1.72878150
142Large hands (HP:0001176)1.71359787
143Inappropriate behavior (HP:0000719)1.70455227
144Combined immunodeficiency (HP:0005387)1.69991481
145Polycythemia (HP:0001901)1.69781382
146Curly hair (HP:0002212)1.69770276
147Hypoplastic iliac wings (HP:0002866)1.69087885
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68803265
149Cafe-au-lait spot (HP:0000957)1.68401062
150Hyperglycinuria (HP:0003108)1.68065140
151Urinary bladder sphincter dysfunction (HP:0002839)1.66314436
152Chronic hepatic failure (HP:0100626)1.65405946
153Urinary urgency (HP:0000012)1.65242967
154Pseudobulbar signs (HP:0002200)1.65132968
155Agnosia (HP:0010524)1.64869462
156Dysmetric saccades (HP:0000641)1.64740173
157Thickened helices (HP:0000391)1.64319056
158Ankyloglossia (HP:0010296)1.64222625
159Abnormality of glycine metabolism (HP:0010895)1.63638269
160Abnormality of serine family amino acid metabolism (HP:0010894)1.63638269
161Coarse hair (HP:0002208)1.63478317
162Hypochromic microcytic anemia (HP:0004840)1.62550341
163Abnormality of the fingertips (HP:0001211)1.61607119
164Reticulocytosis (HP:0001923)1.61603713
165Hyperammonemia (HP:0001987)1.61171281
166Gingival bleeding (HP:0000225)1.60570370
167Arterial thrombosis (HP:0004420)1.57630941
168Gastrointestinal infarctions (HP:0005244)1.56842561
169Abnormality of the frontal sinuses (HP:0002687)1.56276494
170Hydroxyprolinuria (HP:0003080)1.56164910
171Abnormality of proline metabolism (HP:0010907)1.56164910
172Thrombophlebitis (HP:0004418)1.56158661
173Abnormality of the Achilles tendon (HP:0005109)1.55421245
174Intention tremor (HP:0002080)1.55026379
175Striae distensae (HP:0001065)1.54606567
176T lymphocytopenia (HP:0005403)1.54134426
177Hyperglycinemia (HP:0002154)1.54055997
178Sensorimotor neuropathy (HP:0007141)1.53977017
179Thickened calvaria (HP:0002684)1.53333252
180Protuberant abdomen (HP:0001538)1.52882072
181Autoimmune thrombocytopenia (HP:0001973)1.52514315
182Truncal obesity (HP:0001956)1.52339035
183Difficulty running (HP:0009046)1.52140179
184Abnormality of the peritoneum (HP:0002585)1.51970019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.58684676
2CDK123.54053807
3PKN22.76573273
4TRIB32.67619324
5LATS12.28142269
6SCYL22.23154789
7EIF2AK32.22394964
8CAMK1D2.15253585
9PLK42.09537634
10CAMK1G1.92198803
11PNCK1.85685642
12CDK191.81234097
13JAK11.77718652
14SIK11.76701497
15TTN1.73459673
16YES11.72483471
17STK38L1.71659832
18JAK31.70770774
19STK101.69075676
20FGFR41.63058151
21FRK1.57895097
22PTK61.57630398
23FGFR21.57206771
24TYK21.54705896
25NLK1.52539243
26FGFR31.42600481
27CDK61.41925733
28RIPK41.40619097
29KSR21.38276668
30EEF2K1.36576473
31PTK2B1.36515831
32PDGFRA1.36394758
33RIPK11.34626277
34MAP3K101.30232901
35WEE11.28198171
36MAP3K81.27892406
37PDK11.27815695
38MAP3K91.27306800
39WNK11.26424477
40TAOK31.26035819
41RET1.22167966
42PDPK11.22056028
43SGK31.21659700
44TYRO31.19748825
45NEK91.19341881
46TTK1.17895678
47MAP3K21.15399096
48PLK21.14922654
49OXSR11.14859230
50JAK21.14530279
51STK31.12881981
52TAOK21.12246479
53PDGFRB1.11809006
54CDK31.09693502
55MAP3K131.09511103
56ALK1.09001812
57ERBB31.07807339
58FLT31.05240602
59BRSK21.04443248
60BMPR1B1.04240319
61CSK1.01947609
62RPS6KB11.01941131
63DYRK31.01425207
64LRRK21.00740647
65GRK61.00680239
66MET0.99154942
67DMPK0.98299141
68PIM10.97943692
69NTRK10.96882710
70MTOR0.95436685
71MAP4K10.93600171
72RAF10.90642704
73EPHB10.89731730
74CDK90.88456287
75ITK0.85172425
76ATM0.84894299
77PDK30.84168153
78PDK40.84168153
79PINK10.83653947
80NEK60.83283814
81AKT30.80825121
82STK240.80367574
83CAMKK10.79989536
84TSSK60.79481377
85MAP3K50.79170279
86BCR0.79074478
87PTK20.78169379
88STK110.75799230
89PIK3CG0.75751491
90BMPR20.74976854
91BLK0.74080799
92MARK30.73953460
93MAP3K140.73472029
94BRD40.72841632
95PDK20.72815669
96PASK0.72765300
97TEC0.72236266
98MAP3K70.71148821
99FGFR10.70869228
100PRKCH0.70105199
101ERN10.69834481
102TGFBR20.69352195
103SGK20.68606567
104CSF1R0.68544306
105BMX0.66689580
106MELK0.65074559
107STK390.63684134
108PAK60.62771783
109CHEK10.62708409
110ZAK0.61997006
111KSR10.58406443
112TRPM70.58217529
113STK380.57917730
114EGFR0.56983951
115ATR0.56856329
116ERBB40.55784465
117PRKAA20.55394688
118CSNK1D0.55318864
119OBSCN0.54809790
120CDK40.52965595
121PRKCQ0.52474702
122LATS20.52050570
123FGR0.50172539
124PAK30.50031146
125PRKAA10.49833162
126MAPK110.48588970
127SGK10.47910124
128SGK2230.47276189
129SGK4940.47276189
130PRPF4B0.45541976
131MAPK100.45256339
132HCK0.44254065
133DDR20.43609094
134PLK10.43334134
135SIK20.43222910
136STK40.42997391
137IRAK10.42119101
138MAP2K30.41957314
139MAP2K60.41313683
140GSK3A0.41006615
141INSR0.40862669
142BTK0.40433650
143IRAK40.39923788
144NTRK30.38525740
145MAP3K40.38364790
146CHEK20.37955033
147FES0.35227747
148TGFBR10.33904090

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.45480221
2Non-homologous end-joining_Homo sapiens_hsa034503.11938479
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10972470
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.57965834
5Arginine biosynthesis_Homo sapiens_hsa002202.51073673
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81238829
7Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.78693027
8Cell cycle_Homo sapiens_hsa041101.75488097
9Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71711040
10Regulation of autophagy_Homo sapiens_hsa041401.68840164
11Complement and coagulation cascades_Homo sapiens_hsa046101.68147815
12Bile secretion_Homo sapiens_hsa049761.63944660
13mRNA surveillance pathway_Homo sapiens_hsa030151.55886224
14Dorso-ventral axis formation_Homo sapiens_hsa043201.54877520
15Staphylococcus aureus infection_Homo sapiens_hsa051501.52504210
16Homologous recombination_Homo sapiens_hsa034401.50677540
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49830942
18PPAR signaling pathway_Homo sapiens_hsa033201.48949484
19Fatty acid degradation_Homo sapiens_hsa000711.40441216
20ErbB signaling pathway_Homo sapiens_hsa040121.38509513
21Lysine degradation_Homo sapiens_hsa003101.33015769
22Acute myeloid leukemia_Homo sapiens_hsa052211.25918895
23Tryptophan metabolism_Homo sapiens_hsa003801.24681756
24Mismatch repair_Homo sapiens_hsa034301.23275818
25Oocyte meiosis_Homo sapiens_hsa041141.22380592
26RNA transport_Homo sapiens_hsa030131.21111045
27Caffeine metabolism_Homo sapiens_hsa002321.20547319
28mTOR signaling pathway_Homo sapiens_hsa041501.20311852
29Insulin resistance_Homo sapiens_hsa049311.17178287
30Colorectal cancer_Homo sapiens_hsa052101.16421046
31Fanconi anemia pathway_Homo sapiens_hsa034601.15794326
32Fatty acid metabolism_Homo sapiens_hsa012121.11343403
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09599662
34ABC transporters_Homo sapiens_hsa020101.08111690
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07413031
36Propanoate metabolism_Homo sapiens_hsa006401.07364822
37Butanoate metabolism_Homo sapiens_hsa006501.07074822
38Measles_Homo sapiens_hsa051621.06133695
39Fatty acid biosynthesis_Homo sapiens_hsa000611.06025015
40Basal transcription factors_Homo sapiens_hsa030221.03302493
41p53 signaling pathway_Homo sapiens_hsa041151.02737637
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00908952
43Selenocompound metabolism_Homo sapiens_hsa004500.99129604
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97572042
45Viral carcinogenesis_Homo sapiens_hsa052030.97365985
46B cell receptor signaling pathway_Homo sapiens_hsa046620.96265071
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.96191080
48N-Glycan biosynthesis_Homo sapiens_hsa005100.93046626
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91051083
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90562413
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88114994
52Fat digestion and absorption_Homo sapiens_hsa049750.87858145
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86974984
54Osteoclast differentiation_Homo sapiens_hsa043800.86835992
55Type II diabetes mellitus_Homo sapiens_hsa049300.86665302
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86188990
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.85340001
58Glycerolipid metabolism_Homo sapiens_hsa005610.85270778
59Hepatitis B_Homo sapiens_hsa051610.83334325
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79090200
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78652172
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76904465
63Starch and sucrose metabolism_Homo sapiens_hsa005000.76273164
64Adherens junction_Homo sapiens_hsa045200.75386566
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75215522
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74223071
67Estrogen signaling pathway_Homo sapiens_hsa049150.73792719
68Nucleotide excision repair_Homo sapiens_hsa034200.73642046
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72841782
70Chronic myeloid leukemia_Homo sapiens_hsa052200.71862316
71Toxoplasmosis_Homo sapiens_hsa051450.71391049
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70701626
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70670775
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.70281940
75Legionellosis_Homo sapiens_hsa051340.69574557
76Pancreatic cancer_Homo sapiens_hsa052120.69382707
77Vitamin B6 metabolism_Homo sapiens_hsa007500.69261856
78beta-Alanine metabolism_Homo sapiens_hsa004100.68876925
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68615638
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67204947
81TGF-beta signaling pathway_Homo sapiens_hsa043500.67119995
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66229718
83Platelet activation_Homo sapiens_hsa046110.66212161
84Circadian rhythm_Homo sapiens_hsa047100.66109396
85Renal cell carcinoma_Homo sapiens_hsa052110.65860449
86Herpes simplex infection_Homo sapiens_hsa051680.63453291
87AMPK signaling pathway_Homo sapiens_hsa041520.63368906
88Non-small cell lung cancer_Homo sapiens_hsa052230.63041452
89Glioma_Homo sapiens_hsa052140.62977838
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62782794
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.62527798
92RNA degradation_Homo sapiens_hsa030180.62229107
93Proteoglycans in cancer_Homo sapiens_hsa052050.62122284
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.61291792
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58044630
96Melanoma_Homo sapiens_hsa052180.57369368
97Peroxisome_Homo sapiens_hsa041460.57343627
98Amoebiasis_Homo sapiens_hsa051460.56675252
99Focal adhesion_Homo sapiens_hsa045100.56414769
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56056422
101VEGF signaling pathway_Homo sapiens_hsa043700.55968548
102Inositol phosphate metabolism_Homo sapiens_hsa005620.55926990
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55907530
104Vitamin digestion and absorption_Homo sapiens_hsa049770.55464466
105Renin-angiotensin system_Homo sapiens_hsa046140.55457183
106Hepatitis C_Homo sapiens_hsa051600.55218606
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55166521
108FoxO signaling pathway_Homo sapiens_hsa040680.54974432
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.54940104
110Insulin signaling pathway_Homo sapiens_hsa049100.54246644
111Glucagon signaling pathway_Homo sapiens_hsa049220.54057884
112Endometrial cancer_Homo sapiens_hsa052130.53558358
113Tuberculosis_Homo sapiens_hsa051520.52427309
114Thyroid cancer_Homo sapiens_hsa052160.51372560
115Chemokine signaling pathway_Homo sapiens_hsa040620.50801470
116Biosynthesis of amino acids_Homo sapiens_hsa012300.50427225
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49709743
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.49295570
119Lysosome_Homo sapiens_hsa041420.49106706
120Carbon metabolism_Homo sapiens_hsa012000.49009364
121T cell receptor signaling pathway_Homo sapiens_hsa046600.48783442
122Long-term potentiation_Homo sapiens_hsa047200.48096066
123Histidine metabolism_Homo sapiens_hsa003400.48067355
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47638056
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.47476596
126Thyroid hormone synthesis_Homo sapiens_hsa049180.46158712
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.46125323
128GnRH signaling pathway_Homo sapiens_hsa049120.46005003
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45505862
130MicroRNAs in cancer_Homo sapiens_hsa052060.45326424
131Leishmaniasis_Homo sapiens_hsa051400.44734378
132Prion diseases_Homo sapiens_hsa050200.44645269
133HTLV-I infection_Homo sapiens_hsa051660.44363512
134Prolactin signaling pathway_Homo sapiens_hsa049170.44309345
135Antigen processing and presentation_Homo sapiens_hsa046120.43877339
136Small cell lung cancer_Homo sapiens_hsa052220.42264482
137Choline metabolism in cancer_Homo sapiens_hsa052310.41817357
138TNF signaling pathway_Homo sapiens_hsa046680.41477460
139Prostate cancer_Homo sapiens_hsa052150.40819657
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39961399
141Influenza A_Homo sapiens_hsa051640.39624352
142Retinol metabolism_Homo sapiens_hsa008300.39351253
143Gastric acid secretion_Homo sapiens_hsa049710.38126804

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