TRAPPC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive mental retardation. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.93768751
2synaptic vesicle maturation (GO:0016188)4.91500375
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.85070637
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.66382100
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.61681446
6regulation of synaptic vesicle exocytosis (GO:2000300)4.50206396
7synaptic vesicle exocytosis (GO:0016079)4.49221447
8regulation of synaptic vesicle transport (GO:1902803)4.19881508
9glutamate secretion (GO:0014047)4.15743524
10locomotory exploration behavior (GO:0035641)4.10925387
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.03341376
12sodium ion export (GO:0071436)3.99681150
13activation of protein kinase A activity (GO:0034199)3.89970407
14negative regulation of erythrocyte differentiation (GO:0045647)3.86863115
15cellular potassium ion homeostasis (GO:0030007)3.79404050
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71163591
17neurotransmitter secretion (GO:0007269)3.63264895
18regulation of synapse structural plasticity (GO:0051823)3.58099507
19cell communication by electrical coupling (GO:0010644)3.56041487
20vocalization behavior (GO:0071625)3.54284810
21membrane depolarization during action potential (GO:0086010)3.47164073
22proline transport (GO:0015824)3.45679371
23regulation of ARF protein signal transduction (GO:0032012)3.43116667
24regulation of glutamate receptor signaling pathway (GO:1900449)3.26094943
25response to pheromone (GO:0019236)3.25618908
26protein localization to synapse (GO:0035418)3.24214421
27COPI coating of Golgi vesicle (GO:0048205)3.19698727
28Golgi transport vesicle coating (GO:0048200)3.19698727
29cerebellar Purkinje cell differentiation (GO:0021702)3.19659778
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17611588
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.09502452
32positive regulation of synapse maturation (GO:0090129)3.08376815
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.08192370
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07420964
35exploration behavior (GO:0035640)3.07116695
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04340028
37calcium ion-dependent exocytosis (GO:0017156)3.03719478
38synaptic vesicle endocytosis (GO:0048488)3.00686188
39potassium ion import (GO:0010107)2.99770159
40positive regulation of receptor recycling (GO:0001921)2.95708622
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93951095
42neuromuscular process controlling posture (GO:0050884)2.89903422
43vesicle transport along microtubule (GO:0047496)2.89226568
44neurotransmitter transport (GO:0006836)2.88303873
45neuronal action potential propagation (GO:0019227)2.88030894
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.85620853
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85224803
48cerebellar Purkinje cell layer development (GO:0021680)2.84432481
49regulation of voltage-gated calcium channel activity (GO:1901385)2.82521039
50regulation of neuronal synaptic plasticity (GO:0048168)2.82353858
51regulation of ARF GTPase activity (GO:0032312)2.82197774
52protein targeting to Golgi (GO:0000042)2.81126761
53layer formation in cerebral cortex (GO:0021819)2.80045279
54detection of calcium ion (GO:0005513)2.78791581
55glycine transport (GO:0015816)2.77624170
56NADH metabolic process (GO:0006734)2.76132592
57retrograde transport, vesicle recycling within Golgi (GO:0000301)2.75274237
58potassium ion homeostasis (GO:0055075)2.74357114
59striatum development (GO:0021756)2.72310698
60cell communication involved in cardiac conduction (GO:0086065)2.71436402
61regulation of neurotransmitter secretion (GO:0046928)2.71298189
62mannose metabolic process (GO:0006013)2.71173179
63axon cargo transport (GO:0008088)2.71110400
64membrane repolarization (GO:0086009)2.70629965
65histone H3-K36 demethylation (GO:0070544)2.70541315
66regulation of T-helper 2 cell differentiation (GO:0045628)2.70185089
67regulation of calcium ion transmembrane transporter activity (GO:1901019)2.69935635
68regulation of calcium ion transmembrane transport (GO:1903169)2.69935635
69positive regulation of gamma-delta T cell activation (GO:0046645)2.68719145
70negative regulation of myotube differentiation (GO:0010832)2.68445236
71positive regulation of membrane potential (GO:0045838)2.67755628
72negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67609008
73dopamine receptor signaling pathway (GO:0007212)2.67224645
74neuron cell-cell adhesion (GO:0007158)2.66799296
75regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65748330
76detection of light stimulus involved in visual perception (GO:0050908)2.65425708
77detection of light stimulus involved in sensory perception (GO:0050962)2.65425708
78neutrophil activation involved in immune response (GO:0002283)2.65138126
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.65006644
80synaptic transmission, glutamatergic (GO:0035249)2.64353942
81cellular sodium ion homeostasis (GO:0006883)2.62925200
82cellular response to epinephrine stimulus (GO:0071872)2.62552667
83establishment of protein localization to Golgi (GO:0072600)2.61906874
84response to muramyl dipeptide (GO:0032495)2.61294793
85regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60786646
86positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60575156
87innervation (GO:0060384)2.59717973
88regulation of synaptic transmission, dopaminergic (GO:0032225)2.59530395
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.59394694
90insulin secretion (GO:0030073)2.58315270
91regulation of long-term neuronal synaptic plasticity (GO:0048169)2.58195630
92skeletal muscle adaptation (GO:0043501)2.57564420
93positive regulation of potassium ion transmembrane transport (GO:1901381)2.54769575
94negative regulation of type 2 immune response (GO:0002829)2.54338481
95regulation of neurotransmitter levels (GO:0001505)2.54261453
96gamma-aminobutyric acid transport (GO:0015812)2.53511877
97regulation of clathrin-mediated endocytosis (GO:2000369)2.53504230
98intracellular estrogen receptor signaling pathway (GO:0030520)2.53307309
99regulation of vesicle fusion (GO:0031338)2.53100142
100regulation of neurotransmitter transport (GO:0051588)2.52331073
101plasma membrane repair (GO:0001778)2.52282946
102regulation of calcium ion-dependent exocytosis (GO:0017158)2.51547641
103sarcoplasmic reticulum calcium ion transport (GO:0070296)2.51476182
104organelle transport along microtubule (GO:0072384)2.51375390
105cellular response to monoamine stimulus (GO:0071868)2.49685742
106cellular response to catecholamine stimulus (GO:0071870)2.49685742
107membrane hyperpolarization (GO:0060081)2.48176816
108germinal center formation (GO:0002467)2.47819103
109macrophage activation involved in immune response (GO:0002281)2.47728246
110regulation of NFAT protein import into nucleus (GO:0051532)2.47656493
111neuron-neuron synaptic transmission (GO:0007270)2.47338902
112regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.46660043
113ionotropic glutamate receptor signaling pathway (GO:0035235)2.46147223
114positive regulation of vesicle fusion (GO:0031340)2.45086435
115positive regulation of Rap GTPase activity (GO:0032854)2.44345064
116long-term memory (GO:0007616)2.44147939
117regulation of sodium ion transmembrane transporter activity (GO:2000649)2.43437181
118membrane depolarization (GO:0051899)2.43425973
119negative regulation of cell size (GO:0045792)2.43275062
120positive regulation of sodium ion transport (GO:0010765)2.42765271
121regulation of leukocyte degranulation (GO:0043300)2.42748388
122chemosensory behavior (GO:0007635)2.42247888
123macroautophagy (GO:0016236)2.42026632
124regulation of membrane repolarization (GO:0060306)2.41586790
125adenosine receptor signaling pathway (GO:0001973)2.36331366
126positive regulation by symbiont of host defense response (GO:0052509)2.35058643
127modulation by symbiont of host defense response (GO:0052031)2.35058643
128modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35058643
129modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35058643
130positive regulation by organism of defense response of other organism involved in symbiotic interact2.35058643
131modulation by symbiont of host immune response (GO:0052553)2.35058643
132protein localization to endosome (GO:0036010)2.34412389
133skeletal muscle contraction (GO:0003009)2.34364841
134signal complex assembly (GO:0007172)2.33977601
135barbed-end actin filament capping (GO:0051016)2.33403348
136regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.31878674
137actin filament polymerization (GO:0030041)2.31129269
138regulation of gamma-delta T cell activation (GO:0046643)2.31119548
139regulation of platelet aggregation (GO:0090330)2.30970228
140histone H3-K9 demethylation (GO:0033169)2.29094939
141histone lysine demethylation (GO:0070076)2.28456387
142regulation of myeloid leukocyte mediated immunity (GO:0002886)2.28043665
143regulation of regulated secretory pathway (GO:1903305)2.27711429
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.24471907
145negative regulation of cell killing (GO:0031342)2.24471907
146response to peptidoglycan (GO:0032494)2.24123043
147regulation of gamma-delta T cell differentiation (GO:0045586)2.24121841
148striated muscle atrophy (GO:0014891)2.22811878
149cerebellar granule cell differentiation (GO:0021707)2.19156355
150receptor recycling (GO:0001881)2.17739335
151stress fiber assembly (GO:0043149)2.16218737
152regulation of necroptotic process (GO:0060544)2.15461499
153corticosteroid receptor signaling pathway (GO:0031958)2.14984446
154regulation of mast cell degranulation (GO:0043304)2.14550991
155glucocorticoid receptor signaling pathway (GO:0042921)2.14177403
156histone demethylation (GO:0016577)2.14156455
157creatine metabolic process (GO:0006600)2.12930935
158megakaryocyte development (GO:0035855)2.12930589
159negative regulation of granulocyte differentiation (GO:0030853)2.12197421
160regulation of defense response to virus by virus (GO:0050690)2.12077264
161regulation of early endosome to late endosome transport (GO:2000641)2.10104020
162response to epinephrine (GO:0071871)2.08324512
163positive regulation of cellular amide metabolic process (GO:0034250)2.07802991
164response to laminar fluid shear stress (GO:0034616)2.07725741
165peptidyl-tyrosine autophosphorylation (GO:0038083)2.06925148
166phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.05476889
167protein targeting to plasma membrane (GO:0072661)2.05152172
168regulation of receptor recycling (GO:0001919)2.05058247
169cell-substrate adherens junction assembly (GO:0007045)2.04714652
170focal adhesion assembly (GO:0048041)2.04714652
171adherens junction assembly (GO:0034333)2.04519748
172activation of Rac GTPase activity (GO:0032863)2.04366526
173activation of JUN kinase activity (GO:0007257)2.03889281
174detection of molecule of bacterial origin (GO:0032490)2.02744051
175response to monoamine (GO:0071867)2.02400579
176response to catecholamine (GO:0071869)2.02400579
177regulation of interleukin-13 production (GO:0032656)2.02254669
178negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.01205250
179B cell receptor signaling pathway (GO:0050853)2.00880291
180regulation of mast cell activation involved in immune response (GO:0033006)2.00613922
181platelet aggregation (GO:0070527)1.97783017
182regulation of Rap GTPase activity (GO:0032317)1.97390655
183antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G1.96686399
184positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.95612381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.13310909
2* DROSHA_22980978_ChIP-Seq_HELA_Human2.68889400
3* REST_21632747_ChIP-Seq_MESCs_Mouse2.63750481
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.61311189
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.45673044
6VDR_21846776_ChIP-Seq_THP-1_Human2.42116685
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.37677796
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35004189
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24085547
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20054445
11SCL_19346495_ChIP-Seq_HPC-7_Human2.19890690
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.14643076
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04999519
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02910032
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01252118
16MYC_22102868_ChIP-Seq_BL_Human1.96907925
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95058960
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91026620
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89752596
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83626406
21GBX2_23144817_ChIP-Seq_PC3_Human1.82349192
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.79625781
23VDR_24763502_ChIP-Seq_THP-1_Human1.78982658
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78344014
25* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78079749
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76515071
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73867106
28EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69823175
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.69479030
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68977573
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68977573
32RACK7_27058665_Chip-Seq_MCF-7_Human1.67644660
33KDM2B_26808549_Chip-Seq_K562_Human1.66614254
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64377717
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63277811
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63201986
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62883507
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62879473
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58746544
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58061795
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57369449
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57368843
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56043598
44* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55559797
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54603742
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54570248
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53552360
48LXR_22292898_ChIP-Seq_THP-1_Human1.49136418
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.49067857
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48241999
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.46684752
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46149151
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45951108
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43984634
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43159866
56ZNF274_21170338_ChIP-Seq_K562_Hela1.41954095
57MAF_26560356_Chip-Seq_TH1_Human1.41484269
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41056949
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39623491
60* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38647525
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.37825718
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35080226
63* UTX_26944678_Chip-Seq_JUKART_Human1.34345889
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33528878
65* SMC4_20622854_ChIP-Seq_HELA_Human1.33526522
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.32100356
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31257791
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31175487
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30251539
70* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28550858
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28348339
72RUNX_20019798_ChIP-Seq_JUKART_Human1.27977792
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.27375325
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26842557
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.26095472
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25996158
77* GATA2_19941826_ChIP-Seq_K562_Human1.25781846
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25528169
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.25283867
80* TET1_21490601_ChIP-Seq_MESCs_Mouse1.23970989
81CTCF_27219007_Chip-Seq_Bcells_Human1.23205897
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22733079
83KDM2B_26808549_Chip-Seq_DND41_Human1.21854672
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19977031
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19865672
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19577238
87AR_19668381_ChIP-Seq_PC3_Human1.18144544
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17688413
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16137939
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.15767536
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.15492532
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13917228
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.12960095
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.12927314
95* GATA1_19941827_ChIP-Seq_MEL_Mouse1.12464876
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.12115552
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.10832991
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10623368
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09617969
100* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09551529
101P68_20966046_ChIP-Seq_HELA_Human1.09224458
102TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09211626
103ZNF263_19887448_ChIP-Seq_K562_Human1.09074389
104MAF_26560356_Chip-Seq_TH2_Human1.07207340
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07191907
106* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06600973
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06167642
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02700742
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.01946807
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01704296
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01414397
112NCOR1_26117541_ChIP-Seq_K562_Human1.01133223
113* SPI1_23127762_ChIP-Seq_K562_Human1.01069383
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00746893
115ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00682006
116BCOR_27268052_Chip-Seq_Bcells_Human1.00009251
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98890423
118KLF4_19829295_ChIP-Seq_ESCs_Human0.98553018
119GATA1_19941826_ChIP-Seq_K562_Human0.97905319
120TP63_17297297_ChIP-ChIP_HaCaT_Human0.97460243
121ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97268430
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97264910
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97170763
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96940235
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.94891284
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94624539
127CREB1_26743006_Chip-Seq_LNCaP_Human0.94612251
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94373764
129* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93978742
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.93960277
131* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92595434
132TP63_22573176_ChIP-Seq_HFKS_Human0.91326004
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91057198
134OCT4_19829295_ChIP-Seq_ESCs_Human0.90882665
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.90674871
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90626108
137* TCF7_22412390_ChIP-Seq_EML_Mouse0.88970325
138AR_25329375_ChIP-Seq_VCAP_Human0.88927430
139* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88378880
140* SMAD4_21741376_ChIP-Seq_ESCs_Human0.87704307
141* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87325678
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.87237444
143* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87037765
144* STAT3_23295773_ChIP-Seq_U87_Human0.86797622
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86372320
146EP300_21415370_ChIP-Seq_HL-1_Mouse0.85833968
147EED_16625203_ChIP-ChIP_MESCs_Mouse0.85809713
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85759370
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85288159
150TBX20_22080862_ChIP-Seq_HEART_Mouse0.85107757
151TBX20_22328084_ChIP-Seq_HEART_Mouse0.85107757
152KDM2B_26808549_Chip-Seq_JURKAT_Human0.84714342
153AHR_22903824_ChIP-Seq_MCF-7_Human0.84477100
154* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84228469
155TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83522809
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83451989
157* TP53_23651856_ChIP-Seq_MEFs_Mouse0.83340997
158RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83330957
159* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83112719
160BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81917074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.74082433
2MP0005451_abnormal_body_composition3.16799272
3MP0005464_abnormal_platelet_physiology3.10007900
4MP0003635_abnormal_synaptic_transmissio3.04836669
5MP0004270_analgesia2.88058376
6MP0009780_abnormal_chondrocyte_physiolo2.85096199
7MP0002837_dystrophic_cardiac_calcinosis2.61740367
8MP0002909_abnormal_adrenal_gland2.61328680
9MP0008260_abnormal_autophagy2.57858132
10MP0001968_abnormal_touch/_nociception2.54676604
11MP0000751_myopathy2.49193066
12MP0003183_abnormal_peptide_metabolism2.45321930
13MP0003303_peritoneal_inflammation2.40566592
14MP0002063_abnormal_learning/memory/cond2.30902696
15MP0009046_muscle_twitch2.29518005
16MP0002064_seizures2.22997450
17MP0009745_abnormal_behavioral_response2.22668294
18MP0004858_abnormal_nervous_system2.21812164
19MP0005551_abnormal_eye_electrophysiolog2.12609032
20MP0003880_abnormal_central_pattern2.11821138
21MP0003300_gastrointestinal_ulcer2.11559074
22MP0002734_abnormal_mechanical_nocicepti2.11191015
23MP0005423_abnormal_somatic_nervous2.05841891
24MP0002735_abnormal_chemical_nociception2.04190849
25MP0000013_abnormal_adipose_tissue2.03989632
26MP0004233_abnormal_muscle_weight2.00463122
27MP0002736_abnormal_nociception_after1.99531013
28MP0002822_catalepsy1.98042331
29MP0003436_decreased_susceptibility_to1.95488836
30MP0002272_abnormal_nervous_system1.91874052
31MP0000465_gastrointestinal_hemorrhage1.90191990
32MP0009278_abnormal_bone_marrow1.88598080
33MP0002572_abnormal_emotion/affect_behav1.85863705
34MP0005076_abnormal_cell_differentiation1.80987907
35MP0005409_darkened_coat_color1.80559931
36MP0008961_abnormal_basal_metabolism1.79185646
37MP0003646_muscle_fatigue1.77221815
38MP0002733_abnormal_thermal_nociception1.73465861
39MP0001970_abnormal_pain_threshold1.73276629
40MP0002332_abnormal_exercise_endurance1.71387399
41MP0004811_abnormal_neuron_physiology1.66798012
42MP0006072_abnormal_retinal_apoptosis1.65083142
43MP0004130_abnormal_muscle_cell1.64948925
44MP0005646_abnormal_pituitary_gland1.60575354
45MP0008569_lethality_at_weaning1.59664430
46MP0004043_abnormal_pH_regulation1.59093157
47MP0003091_abnormal_cell_migration1.57302684
48MP0002653_abnormal_ependyma_morphology1.56965738
49MP0008004_abnormal_stomach_pH1.54021698
50MP0003191_abnormal_cellular_cholesterol1.51916140
51MP0003724_increased_susceptibility_to1.51854800
52MP0003329_amyloid_beta_deposits1.51316752
53MP0001501_abnormal_sleep_pattern1.51092649
54MP0005410_abnormal_fertilization1.50544021
55MP0003690_abnormal_glial_cell1.50345542
56MP0004145_abnormal_muscle_electrophysio1.50114326
57MP0003879_abnormal_hair_cell1.48477329
58MP0002067_abnormal_sensory_capabilities1.48312713
59MP0004947_skin_inflammation1.47851834
60MP0001986_abnormal_taste_sensitivity1.45973679
61MP0003787_abnormal_imprinting1.44986919
62MP0003172_abnormal_lysosome_physiology1.44292536
63MP0005670_abnormal_white_adipose1.43472139
64MP0010386_abnormal_urinary_bladder1.42426658
65MP0003828_pulmonary_edema1.38859777
66MP0004215_abnormal_myocardial_fiber1.36561254
67MP0005253_abnormal_eye_physiology1.35994134
68MP0000569_abnormal_digit_pigmentation1.35104797
69MP0008874_decreased_physiological_sensi1.35048156
70MP0003122_maternal_imprinting1.33626530
71MP0003633_abnormal_nervous_system1.31987159
72MP0003763_abnormal_thymus_physiology1.31908706
73MP0004036_abnormal_muscle_relaxation1.31296365
74MP0003283_abnormal_digestive_organ1.28413761
75MP0001984_abnormal_olfaction1.27561774
76MP0003566_abnormal_cell_adhesion1.26710218
77MP0001486_abnormal_startle_reflex1.26656414
78MP0000955_abnormal_spinal_cord1.25978728
79MP0003705_abnormal_hypodermis_morpholog1.25613823
80MP0005083_abnormal_biliary_tract1.25104401
81MP0009840_abnormal_foam_cell1.24099135
82MP0003656_abnormal_erythrocyte_physiolo1.23920372
83MP0005386_behavior/neurological_phenoty1.22429607
84MP0004924_abnormal_behavior1.22429607
85MP0002184_abnormal_innervation1.20633258
86MP0002419_abnormal_innate_immunity1.19676548
87MP0002229_neurodegeneration1.19345376
88MP0002882_abnormal_neuron_morphology1.19094856
89MP0001502_abnormal_circadian_rhythm1.18518634
90MP0000749_muscle_degeneration1.18423358
91MP0003453_abnormal_keratinocyte_physiol1.18222736
92MP0000747_muscle_weakness1.17834325
93MP0003045_fibrosis1.17817403
94MP0002009_preneoplasia1.16497130
95MP0003075_altered_response_to1.16370868
96MP0006276_abnormal_autonomic_nervous1.13949526
97MP0000003_abnormal_adipose_tissue1.13375342
98MP0001545_abnormal_hematopoietic_system1.12981534
99MP0005397_hematopoietic_system_phenotyp1.12981534
100MP0000604_amyloidosis1.12502468
101MP0001440_abnormal_grooming_behavior1.12427895
102MP0005025_abnormal_response_to1.11824021
103MP0001835_abnormal_antigen_presentation1.11068593
104MP0003866_abnormal_defecation1.10870954
105MP0005645_abnormal_hypothalamus_physiol1.10804019
106MP0002693_abnormal_pancreas_physiology1.09927313
107MP0002971_abnormal_brown_adipose1.09416604
108MP0004084_abnormal_cardiac_muscle1.09203409
109MP0002557_abnormal_social/conspecific_i1.07908652
110MP0002269_muscular_atrophy1.07695218
111MP0010234_abnormal_vibrissa_follicle1.06325615
112MP0002066_abnormal_motor_capabilities/c1.06167722
113MP0002106_abnormal_muscle_physiology1.02328884
114MP0005535_abnormal_body_temperature1.01757653
115MP0001849_ear_inflammation1.01593602
116MP0004381_abnormal_hair_follicle1.00411755
117MP0004085_abnormal_heartbeat1.00394431
118MP0002078_abnormal_glucose_homeostasis0.99775503
119MP0004484_altered_response_of0.99206644
120MP0001765_abnormal_ion_homeostasis0.98616668
121MP0004264_abnormal_extraembryonic_tissu0.96338650
122MP0002090_abnormal_vision0.96294445
123MP0003631_nervous_system_phenotype0.95863072
124MP0001944_abnormal_pancreas_morphology0.95016832
125MP0004147_increased_porphyrin_level0.94027127
126MP0001800_abnormal_humoral_immune0.93578310
127MP0010155_abnormal_intestine_physiology0.93031079
128MP0005000_abnormal_immune_tolerance0.91576996
129MP0004885_abnormal_endolymph0.91461266
130MP0002877_abnormal_melanocyte_morpholog0.91149780
131MP0005310_abnormal_salivary_gland0.90381187
132MP0000685_abnormal_immune_system0.89691932
133MP0002089_abnormal_postnatal_growth/wei0.89115076
134MP0002998_abnormal_bone_remodeling0.88761047
135MP0005375_adipose_tissue_phenotype0.88693942
136MP0002723_abnormal_immune_serum0.88064205
137MP0005621_abnormal_cell_physiology0.87149464
138MP0002234_abnormal_pharynx_morphology0.86873312
139MP0000733_abnormal_muscle_development0.86230845
140MP0001851_eye_inflammation0.86090421
141MP0001533_abnormal_skeleton_physiology0.85954415
142MP0002069_abnormal_eating/drinking_beha0.85928426
143MP0000015_abnormal_ear_pigmentation0.85642197
144MP0002420_abnormal_adaptive_immunity0.85521379
145MP0002638_abnormal_pupillary_reflex0.85225483
146MP0005448_abnormal_energy_balance0.84876932
147MP0003634_abnormal_glial_cell0.84602738
148MP0005058_abnormal_lysosome_morphology0.84290840
149MP0004510_myositis0.84088430
150MP0001819_abnormal_immune_cell0.83642216
151MP0002398_abnormal_bone_marrow0.82910853
152MP0000920_abnormal_myelination0.82772858
153MP0010630_abnormal_cardiac_muscle0.81619430
154MP0002452_abnormal_antigen_presenting0.80982662
155MP0005620_abnormal_muscle_contractility0.80472966
156MP0001790_abnormal_immune_system0.80388043
157MP0005387_immune_system_phenotype0.80388043
158MP0004808_abnormal_hematopoietic_stem0.80375642
159MP0000858_altered_metastatic_potential0.80151777
160MP0000759_abnormal_skeletal_muscle0.79895043
161MP0000249_abnormal_blood_vessel0.79512500
162MP0005666_abnormal_adipose_tissue0.76345406
163MP0003137_abnormal_impulse_conducting0.75812247
164MP0004087_abnormal_muscle_fiber0.74164729
165MP0001664_abnormal_digestion0.73237482

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.72432909
2Congenital stationary night blindness (HP:0007642)4.30997016
3Myokymia (HP:0002411)4.17259082
4Focal motor seizures (HP:0011153)3.96897155
5Central scotoma (HP:0000603)3.68990387
6Focal seizures (HP:0007359)3.61547455
7Prolonged bleeding time (HP:0003010)3.46709815
8Epileptic encephalopathy (HP:0200134)3.38871989
9Atonic seizures (HP:0010819)3.34783585
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.32895721
11Supranuclear gaze palsy (HP:0000605)3.19680254
12Distal lower limb amyotrophy (HP:0008944)3.19122249
13Obstructive sleep apnea (HP:0002870)3.15193079
14Progressive cerebellar ataxia (HP:0002073)3.11322513
15Exercise-induced myalgia (HP:0003738)3.05816467
16Febrile seizures (HP:0002373)3.04935426
17Depression (HP:0000716)3.04284170
18Pheochromocytoma (HP:0002666)2.98305160
19Eczematoid dermatitis (HP:0000976)2.98294901
20Abnormality of the lower motor neuron (HP:0002366)2.93872001
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.89278355
22Action tremor (HP:0002345)2.87989164
23Ankle clonus (HP:0011448)2.87660945
24Increased connective tissue (HP:0009025)2.85827080
25Postural instability (HP:0002172)2.78615112
26Bony spicule pigmentary retinopathy (HP:0007737)2.78297346
27Hyporeflexia of lower limbs (HP:0002600)2.77762343
28Absence seizures (HP:0002121)2.70920435
29Muscle fiber inclusion bodies (HP:0100299)2.68615281
30Distal lower limb muscle weakness (HP:0009053)2.68091052
31Bundle branch block (HP:0011710)2.63470132
32Nemaline bodies (HP:0003798)2.63091889
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.62189515
34Generalized tonic-clonic seizures (HP:0002069)2.60772794
35Abnormality of macular pigmentation (HP:0008002)2.58593012
36Epistaxis (HP:0000421)2.58571949
37Hypercortisolism (HP:0001578)2.57903315
38Abnormality of skeletal muscle fiber size (HP:0012084)2.57582994
39Gingival bleeding (HP:0000225)2.56913248
40Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.54980883
41Menorrhagia (HP:0000132)2.52951534
42Dysmetric saccades (HP:0000641)2.51038948
43Poor eye contact (HP:0000817)2.47710344
44Purpura (HP:0000979)2.47258864
45Impaired social interactions (HP:0000735)2.46355944
46Abnormal social behavior (HP:0012433)2.46355944
47Lower limb amyotrophy (HP:0007210)2.45543131
48Dialeptic seizures (HP:0011146)2.45316771
49Truncal ataxia (HP:0002078)2.44164867
50Abnormal rod and cone electroretinograms (HP:0008323)2.43920403
51Impaired vibration sensation in the lower limbs (HP:0002166)2.43086418
52Colitis (HP:0002583)2.41175375
53Scotoma (HP:0000575)2.40957181
54Neuroendocrine neoplasm (HP:0100634)2.40358569
55Broad face (HP:0000283)2.40346492
56Muscle fiber splitting (HP:0003555)2.38989989
57Cerebral aneurysm (HP:0004944)2.38912587
58Myopathic facies (HP:0002058)2.36690554
59Type 1 muscle fiber predominance (HP:0003803)2.36227022
60Urinary bladder sphincter dysfunction (HP:0002839)2.35366025
61Failure to thrive in infancy (HP:0001531)2.35268366
62Abnormality of the fingertips (HP:0001211)2.34101340
63Resting tremor (HP:0002322)2.33791490
64Ventricular fibrillation (HP:0001663)2.32599790
65Anxiety (HP:0000739)2.31815562
66Abnormal eating behavior (HP:0100738)2.30235962
67Oligomenorrhea (HP:0000876)2.28720301
68Petechiae (HP:0000967)2.27861561
69Slow saccadic eye movements (HP:0000514)2.26140957
70Menstrual irregularities (HP:0000858)2.25010829
71Abnormal platelet volume (HP:0011876)2.24449404
72Neoplasm of the heart (HP:0100544)2.23431932
73Insomnia (HP:0100785)2.20037804
74EEG with generalized epileptiform discharges (HP:0011198)2.18318555
75Cerebral inclusion bodies (HP:0100314)2.17854228
76Urinary urgency (HP:0000012)2.17447686
77Asymmetric septal hypertrophy (HP:0001670)2.16674313
78Bradykinesia (HP:0002067)2.16505591
79Epileptiform EEG discharges (HP:0011182)2.15635636
80Increased cerebral lipofuscin (HP:0011813)2.15003079
81EMG: neuropathic changes (HP:0003445)2.14885136
82Myoglobinuria (HP:0002913)2.14555582
83Cellulitis (HP:0100658)2.13744072
84Hemiplegia (HP:0002301)2.13260006
85Foot dorsiflexor weakness (HP:0009027)2.13141883
86Difficulty running (HP:0009046)2.12746526
87Hand muscle atrophy (HP:0009130)2.12125232
88Large for gestational age (HP:0001520)2.12103907
89Dysdiadochokinesis (HP:0002075)2.11620635
90Spontaneous hematomas (HP:0007420)2.11358057
91Type II diabetes mellitus (HP:0005978)2.09903122
92Subaortic stenosis (HP:0001682)2.09682813
93Abnormality of the left ventricular outflow tract (HP:0011103)2.09682813
94Neurofibrillary tangles (HP:0002185)2.08344497
95Hypsarrhythmia (HP:0002521)2.08319645
96Dysostosis multiplex (HP:0000943)2.08222988
97Increased mean platelet volume (HP:0011877)2.07551488
98Ulnar deviation of the wrist (HP:0003049)2.06743938
99Impaired smooth pursuit (HP:0007772)2.06424847
100Gingivitis (HP:0000230)2.06305163
101Abnormality of macrophages (HP:0004311)2.03238753
102Myotonia (HP:0002486)2.02878274
103Gastrointestinal inflammation (HP:0004386)2.02268434
104Difficulty climbing stairs (HP:0003551)2.01590337
105Growth hormone excess (HP:0000845)2.00797947
106Hypoventilation (HP:0002791)2.00495703
107EMG: myopathic abnormalities (HP:0003458)2.00361102
108Prolonged QT interval (HP:0001657)1.99001525
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98611388
110Hemorrhage of the eye (HP:0011885)1.98257594
111Upper limb amyotrophy (HP:0009129)1.98075085
112Distal upper limb amyotrophy (HP:0007149)1.98075085
113Agitation (HP:0000713)1.97509523
114Rapidly progressive (HP:0003678)1.97277865
115Interstitial pulmonary disease (HP:0006530)1.96894734
116Papilledema (HP:0001085)1.96591569
117Choroideremia (HP:0001139)1.96440664
118Onion bulb formation (HP:0003383)1.94118267
119Abnormality of pain sensation (HP:0010832)1.93126134
120Impaired pain sensation (HP:0007328)1.93126134
121Abnormality of the foot musculature (HP:0001436)1.92398317
122Inflammation of the large intestine (HP:0002037)1.92291991
123Spastic gait (HP:0002064)1.92130175
124Long toe (HP:0010511)1.90687093
125Spinal canal stenosis (HP:0003416)1.90210313
126Abnormal EKG (HP:0003115)1.90010684
127Mucopolysacchariduria (HP:0008155)1.89357563
128Urinary glycosaminoglycan excretion (HP:0003541)1.89357563
129Recurrent abscess formation (HP:0002722)1.87082832
130Increased IgE level (HP:0003212)1.86088447
131Gaze-evoked nystagmus (HP:0000640)1.86010447
132Genetic anticipation (HP:0003743)1.85916980
133Flat acetabular roof (HP:0003180)1.85856783
134Abnormality of ocular smooth pursuit (HP:0000617)1.85281554
135Bulbar palsy (HP:0001283)1.84838106
136Scanning speech (HP:0002168)1.84489173
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84018958
138Polyphagia (HP:0002591)1.83955440
139Progressive sensorineural hearing impairment (HP:0000408)1.83454731
140Neoplasm of the peripheral nervous system (HP:0100007)1.81627542
141Recurrent bacterial skin infections (HP:0005406)1.80830277
142Hyperkalemia (HP:0002153)1.80818545
143Mutism (HP:0002300)1.80241773
144Increased neuronal autofluorescent lipopigment (HP:0002074)1.79928936
145Decreased motor nerve conduction velocity (HP:0003431)1.79765940
146Amyotrophic lateral sclerosis (HP:0007354)1.78096605
147Abnormality of polysaccharide metabolism (HP:0011012)1.78027051
148Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78027051
149Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78027051
150Lower limb muscle weakness (HP:0007340)1.77730261
151Ketoacidosis (HP:0001993)1.77556961
152Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.77351773
153Hyperacusis (HP:0010780)1.76505280
154Loss of speech (HP:0002371)1.73794596
155Rhabdomyolysis (HP:0003201)1.73201688
156Bowel incontinence (HP:0002607)1.72376801
157Sudden death (HP:0001699)1.71915630
158Increased variability in muscle fiber diameter (HP:0003557)1.71547257
159Dysmetria (HP:0001310)1.71515182
160Neuronal loss in central nervous system (HP:0002529)1.71340549
161Clonus (HP:0002169)1.69743018
162Torticollis (HP:0000473)1.68880368
163Insulin-resistant diabetes mellitus (HP:0000831)1.68499408
164Exercise-induced muscle cramps (HP:0003710)1.68487346
165Diplopia (HP:0000651)1.68309951
166Abnormality of binocular vision (HP:0011514)1.68309951
167Psychosis (HP:0000709)1.68254739
168Dyschromatopsia (HP:0007641)1.67292400
169Rigidity (HP:0002063)1.66843005
170Frequent falls (HP:0002359)1.66691213
171Round ear (HP:0100830)1.66345345
172Mildly elevated creatine phosphokinase (HP:0008180)1.66138414
173Thoracic kyphosis (HP:0002942)1.65942902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.33219027
2NTRK32.97352056
3MAP3K92.90491847
4TRIB32.43788296
5MAP3K42.26614445
6ERN12.25394848
7SIK12.25332676
8MINK12.19620434
9CDK122.16332589
10PAK62.15757583
11PDK42.00760155
12PDK32.00760155
13LMTK21.89677083
14KSR21.88226491
15PHKG21.81679285
16PHKG11.81679285
17CAMKK11.81118625
18STK381.81064890
19MAP2K31.75525693
20EPHB11.73908376
21EEF2K1.73327314
22DAPK21.71341554
23NTRK11.70559055
24TAOK11.55188428
25MARK11.55112226
26BLK1.53638061
27CAMKK21.51235938
28PINK11.49662054
29MAP2K41.49121420
30OBSCN1.40399248
31PRKCH1.40013221
32ICK1.35463739
33CCNB11.31088696
34CAMK1G1.27234639
35MAP2K71.27083437
36RET1.26942412
37MAP3K21.26098961
38MAP3K121.24976625
39DAPK11.16713697
40CDK51.15070377
41MAP3K111.12808973
42FGFR41.10065042
43SMG11.08765019
44MAPK131.08209866
45BMX1.07824345
46NTRK21.07464789
47CSF1R1.07386605
48INSRR1.06619255
49PKN21.06120387
50EPHA41.05954554
51PDK11.04670292
52BTK1.02690642
53NEK11.02077496
54SGK2231.01725608
55SGK4941.01725608
56SCYL21.01596966
57MAP3K11.01478667
58CDK191.01442794
59SGK31.00192406
60MAP2K60.99109729
61GRK50.98882493
62PTK2B0.98318569
63MAPK110.96340679
64PDPK10.96056875
65RIPK40.93837046
66SIK20.92949343
67TBK10.92856555
68MARK20.92731106
69PRPF4B0.91533648
70CAMK1D0.91300872
71TAOK20.90146848
72DYRK1B0.89297359
73RIPK10.88331900
74RPS6KA20.87347995
75GRK60.87325482
76MST1R0.85801936
77MTOR0.85790776
78SGK20.84833463
79IRAK30.83250143
80MAPKAPK30.82018873
81TTN0.81090859
82WNK40.79896995
83ARAF0.79507223
84IRAK40.79336161
85MAP3K30.79207896
86HCK0.79024518
87TESK10.78379919
88UHMK10.77471921
89IRAK20.76829441
90JAK10.75995383
91CAMK10.75774689
92SYK0.73546462
93PRKCG0.73324356
94PIK3CG0.72204617
95PDK20.70750391
96FES0.70421469
97SIK30.70347015
98PRKAA10.68847184
99TYK20.68539970
100CDC42BPA0.68520415
101HIPK20.67591920
102MAP3K130.67344173
103MAP3K70.66825494
104TYRO30.66683921
105JAK20.66244768
106STK110.65756083
107FGR0.65644073
108KSR10.64299608
109NEK60.63155177
110WNK10.63118632
111TESK20.62637369
112EPHA20.62524295
113TNK20.62068471
114PAK30.61433329
115PDGFRA0.61070796
116MAPK70.58644310
117TRPM70.57665802
118CDK150.53876596
119CSK0.53676502
120CDK180.53014494
121ALK0.52556574
122RPS6KC10.52176771
123RPS6KL10.52176771
124PRKCZ0.51993939
125CAMK2A0.51845322
126PTK60.51635425
127FGFR30.51376923
128PRKD20.50952234
129EPHA30.49648425
130PRKD10.49056667
131MAP2K10.49005469
132SGK10.48624056
133IKBKE0.46868062
134RPS6KA30.46285576
135CDK140.45714440
136CAMK40.43977478
137CDK11A0.43173084
138MAPK120.42879147
139MAP3K140.42193055
140ZAP700.41971458
141MAP3K60.40508898
142TAOK30.39108872
143RAF10.38718625
144MAP4K10.36465451
145PASK0.35648005
146MAPK100.35629045

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.33757687
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.60632719
3Insulin secretion_Homo sapiens_hsa049112.30779817
4Phototransduction_Homo sapiens_hsa047442.26533455
5Olfactory transduction_Homo sapiens_hsa047402.06092785
6Circadian entrainment_Homo sapiens_hsa047132.02483259
7GABAergic synapse_Homo sapiens_hsa047272.02321261
8Nicotine addiction_Homo sapiens_hsa050331.98338617
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96238451
10Long-term potentiation_Homo sapiens_hsa047201.88677425
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87569193
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77210692
13Morphine addiction_Homo sapiens_hsa050321.76290509
14Dopaminergic synapse_Homo sapiens_hsa047281.74842533
15Acute myeloid leukemia_Homo sapiens_hsa052211.69832204
16B cell receptor signaling pathway_Homo sapiens_hsa046621.65677220
17Collecting duct acid secretion_Homo sapiens_hsa049661.64592905
18Platelet activation_Homo sapiens_hsa046111.63734810
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63247171
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61631964
21Cholinergic synapse_Homo sapiens_hsa047251.61610023
22Salivary secretion_Homo sapiens_hsa049701.60548345
23Amphetamine addiction_Homo sapiens_hsa050311.60278083
24Glutamatergic synapse_Homo sapiens_hsa047241.60011043
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59604984
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59309369
27Type II diabetes mellitus_Homo sapiens_hsa049301.53813409
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52395691
29Gastric acid secretion_Homo sapiens_hsa049711.51728423
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44728135
31Other glycan degradation_Homo sapiens_hsa005111.42505849
32Renin secretion_Homo sapiens_hsa049241.42021837
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37858388
34Osteoclast differentiation_Homo sapiens_hsa043801.36651529
35Taste transduction_Homo sapiens_hsa047421.33577590
36Vibrio cholerae infection_Homo sapiens_hsa051101.32234127
37Oxytocin signaling pathway_Homo sapiens_hsa049211.30872879
38Pancreatic secretion_Homo sapiens_hsa049721.30085771
39Chronic myeloid leukemia_Homo sapiens_hsa052201.27555790
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.27242638
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26489508
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26021575
43Cocaine addiction_Homo sapiens_hsa050301.23154911
44Glucagon signaling pathway_Homo sapiens_hsa049221.19033269
45Renal cell carcinoma_Homo sapiens_hsa052111.16109062
46Calcium signaling pathway_Homo sapiens_hsa040201.15072776
47GnRH signaling pathway_Homo sapiens_hsa049121.13933909
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13338808
49Pancreatic cancer_Homo sapiens_hsa052121.12345916
50Estrogen signaling pathway_Homo sapiens_hsa049151.09905760
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09710162
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08223121
53Notch signaling pathway_Homo sapiens_hsa043301.06921677
54Dilated cardiomyopathy_Homo sapiens_hsa054141.04461283
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.02400585
56cAMP signaling pathway_Homo sapiens_hsa040241.01719329
57Long-term depression_Homo sapiens_hsa047300.99462000
58Gap junction_Homo sapiens_hsa045400.99014955
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98275138
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97289905
61Serotonergic synapse_Homo sapiens_hsa047260.96403819
62Glioma_Homo sapiens_hsa052140.94189650
63Insulin signaling pathway_Homo sapiens_hsa049100.93725983
64mTOR signaling pathway_Homo sapiens_hsa041500.93328964
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92354445
66T cell receptor signaling pathway_Homo sapiens_hsa046600.91672838
67Chemokine signaling pathway_Homo sapiens_hsa040620.91664850
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90269675
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89314924
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89157796
71Hepatitis C_Homo sapiens_hsa051600.85259317
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.85058583
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84508981
74Circadian rhythm_Homo sapiens_hsa047100.84088629
75Cardiac muscle contraction_Homo sapiens_hsa042600.82640461
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.82426242
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82417361
78Tuberculosis_Homo sapiens_hsa051520.81151094
79Leishmaniasis_Homo sapiens_hsa051400.79599466
80Inositol phosphate metabolism_Homo sapiens_hsa005620.79525014
81Amoebiasis_Homo sapiens_hsa051460.79355339
82Thyroid hormone synthesis_Homo sapiens_hsa049180.79334082
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77669096
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75981427
85AMPK signaling pathway_Homo sapiens_hsa041520.75278038
86Insulin resistance_Homo sapiens_hsa049310.74513541
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.73994247
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.73023526
89Toxoplasmosis_Homo sapiens_hsa051450.72971941
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.72865184
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72181950
92Endocytosis_Homo sapiens_hsa041440.71082349
93Focal adhesion_Homo sapiens_hsa045100.69202841
94Pentose phosphate pathway_Homo sapiens_hsa000300.68630395
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67704628
96Dorso-ventral axis formation_Homo sapiens_hsa043200.67359894
97VEGF signaling pathway_Homo sapiens_hsa043700.66189483
98Hepatitis B_Homo sapiens_hsa051610.65945811
99TNF signaling pathway_Homo sapiens_hsa046680.65734442
100FoxO signaling pathway_Homo sapiens_hsa040680.64094173
101Salmonella infection_Homo sapiens_hsa051320.63748540
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.63713634
103ErbB signaling pathway_Homo sapiens_hsa040120.62856761
104Pyruvate metabolism_Homo sapiens_hsa006200.62102029
105Endometrial cancer_Homo sapiens_hsa052130.61367787
106Melanogenesis_Homo sapiens_hsa049160.60845701
107Influenza A_Homo sapiens_hsa051640.59528569
108Shigellosis_Homo sapiens_hsa051310.58763119
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58597449
110Oocyte meiosis_Homo sapiens_hsa041140.57579147
111MAPK signaling pathway_Homo sapiens_hsa040100.57194845
112Lysosome_Homo sapiens_hsa041420.57148858
113HIF-1 signaling pathway_Homo sapiens_hsa040660.56846244
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56576154
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53558622
116Fructose and mannose metabolism_Homo sapiens_hsa000510.51318240
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51298805
118Prolactin signaling pathway_Homo sapiens_hsa049170.51062334
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50030245
120Choline metabolism in cancer_Homo sapiens_hsa052310.49397479
121Type I diabetes mellitus_Homo sapiens_hsa049400.48392658
122Glycerolipid metabolism_Homo sapiens_hsa005610.47152250
123Non-small cell lung cancer_Homo sapiens_hsa052230.47116636
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46846578
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45290989
126Rap1 signaling pathway_Homo sapiens_hsa040150.44827293
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44441120
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42058820
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40088152
130N-Glycan biosynthesis_Homo sapiens_hsa005100.38585295
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37512496
132Protein digestion and absorption_Homo sapiens_hsa049740.37480565
133Fatty acid biosynthesis_Homo sapiens_hsa000610.35717728
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.35693710

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