

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive T cell selection (GO:0043368) | 9.64581645 |
| 2 | positive thymic T cell selection (GO:0045059) | 9.64139364 |
| 3 | interferon-gamma production (GO:0032609) | 9.26956936 |
| 4 | negative T cell selection (GO:0043383) | 8.85830498 |
| 5 | thymic T cell selection (GO:0045061) | 8.52246137 |
| 6 | T cell selection (GO:0045058) | 8.20038695 |
| 7 | negative thymic T cell selection (GO:0045060) | 8.16527809 |
| 8 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.67344745 |
| 9 | * positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 7.29149449 |
| 10 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.86100630 |
| 11 | * T cell receptor signaling pathway (GO:0050852) | 6.72183505 |
| 12 | regulation of gamma-delta T cell activation (GO:0046643) | 6.26234260 |
| 13 | T cell costimulation (GO:0031295) | 6.07833160 |
| 14 | lymphocyte costimulation (GO:0031294) | 5.99609141 |
| 15 | regulation of type B pancreatic cell apoptotic process (GO:2000674) | 5.96299168 |
| 16 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 5.90363235 |
| 17 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.78328191 |
| 18 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 5.75153103 |
| 19 | regulation of T cell tolerance induction (GO:0002664) | 5.70572799 |
| 20 | keratinization (GO:0031424) | 5.46455438 |
| 21 | mast cell activation (GO:0045576) | 5.45329018 |
| 22 | negative regulation of cAMP-mediated signaling (GO:0043951) | 5.37247992 |
| 23 | * antigen receptor-mediated signaling pathway (GO:0050851) | 5.29691628 |
| 24 | regulation of hypersensitivity (GO:0002883) | 5.24682564 |
| 25 | negative regulation of T cell mediated immunity (GO:0002710) | 5.08089718 |
| 26 | * regulation of T cell receptor signaling pathway (GO:0050856) | 4.95305873 |
| 27 | tolerance induction (GO:0002507) | 4.75690822 |
| 28 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.74189760 |
| 29 | response to interleukin-15 (GO:0070672) | 4.73850132 |
| 30 | cellular response to interleukin-15 (GO:0071350) | 4.60068513 |
| 31 | positive regulation of tolerance induction (GO:0002645) | 4.58999044 |
| 32 | * regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.54229293 |
| 33 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.48397519 |
| 34 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.46196836 |
| 35 | negative regulation of cell killing (GO:0031342) | 4.46196836 |
| 36 | V(D)J recombination (GO:0033151) | 4.43971773 |
| 37 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.28089613 |
| 38 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.28089613 |
| 39 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.23121733 |
| 40 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.19626084 |
| 41 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.14255455 |
| 42 | T cell migration (GO:0072678) | 4.14171956 |
| 43 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 4.11869410 |
| 44 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 4.11269057 |
| 45 | leukocyte aggregation (GO:0070486) | 4.07005680 |
| 46 | mast cell degranulation (GO:0043303) | 4.05235571 |
| 47 | mast cell activation involved in immune response (GO:0002279) | 4.05235571 |
| 48 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 4.05163169 |
| 49 | T cell differentiation (GO:0030217) | 4.04810491 |
| 50 | positive regulation of T cell differentiation in thymus (GO:0033089) | 4.00572676 |
| 51 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.98191561 |
| 52 | regulation of tolerance induction (GO:0002643) | 3.97778933 |
| 53 | alpha-beta T cell differentiation (GO:0046632) | 3.94454371 |
| 54 | positive regulation of interleukin-2 production (GO:0032743) | 3.90319288 |
| 55 | regulation of cell killing (GO:0031341) | 3.84486873 |
| 56 | T-helper cell differentiation (GO:0042093) | 3.82376741 |
| 57 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.82376741 |
| 58 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.81501979 |
| 59 | positive regulation of cell killing (GO:0031343) | 3.74836878 |
| 60 | positive regulation of B cell mediated immunity (GO:0002714) | 3.70809717 |
| 61 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.70809717 |
| 62 | alpha-beta T cell activation (GO:0046631) | 3.68025728 |
| 63 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.67983765 |
| 64 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.67715347 |
| 65 | G-protein coupled purinergic receptor signaling pathway (GO:0035588) | 3.61543375 |
| 66 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 3.61348237 |
| 67 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.60528649 |
| 68 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.59943123 |
| 69 | regulation of B cell differentiation (GO:0045577) | 3.59535555 |
| 70 | T cell activation (GO:0042110) | 3.57791881 |
| 71 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.55482813 |
| 72 | dendritic cell chemotaxis (GO:0002407) | 3.55086346 |
| 73 | * immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.54134625 |
| 74 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.50952998 |
| 75 | T cell differentiation involved in immune response (GO:0002292) | 3.50667763 |
| 76 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.50667763 |
| 77 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.50667763 |
| 78 | relaxation of smooth muscle (GO:0044557) | 3.50507988 |
| 79 | positive regulation of B cell differentiation (GO:0045579) | 3.50070638 |
| 80 | glial cell proliferation (GO:0014009) | 3.47558846 |
| 81 | cytidine deamination (GO:0009972) | 3.46306966 |
| 82 | cytidine metabolic process (GO:0046087) | 3.46306966 |
| 83 | cytidine catabolic process (GO:0006216) | 3.46306966 |
| 84 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.45198759 |
| 85 | negative regulation of adaptive immune response (GO:0002820) | 3.44262306 |
| 86 | positive regulation of T cell cytokine production (GO:0002726) | 3.43375211 |
| 87 | positive regulation of humoral immune response (GO:0002922) | 3.42577714 |
| 88 | positive regulation of T cell activation (GO:0050870) | 3.42322321 |
| 89 | hepatocyte apoptotic process (GO:0097284) | 3.42317643 |
| 90 | activated T cell proliferation (GO:0050798) | 3.41564674 |
| 91 | regulation of interleukin-2 production (GO:0032663) | 3.40632407 |
| 92 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.40553640 |
| 93 | positive regulation of microtubule polymerization (GO:0031116) | 3.39965284 |
| 94 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 3.39128133 |
| 95 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.39061240 |
| 96 | DNA deamination (GO:0045006) | 3.38268290 |
| 97 | positive regulation of interleukin-4 production (GO:0032753) | 3.34005276 |
| 98 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.33455559 |
| 99 | negative regulation of T cell apoptotic process (GO:0070233) | 3.32419159 |
| 100 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151) | 3.29499528 |
| 101 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO | 3.29499528 |
| 102 | regulation of acute inflammatory response to antigenic stimulus (GO:0002864) | 3.29238099 |
| 103 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.29014585 |
| 104 | regulation of T cell activation (GO:0050863) | 3.27250438 |
| 105 | dendritic cell migration (GO:0036336) | 3.25548385 |
| 106 | positive regulation of isotype switching (GO:0045830) | 3.25248762 |
| 107 | regulation of alpha-beta T cell activation (GO:0046634) | 3.24346052 |
| 108 | positive regulation of defense response to virus by host (GO:0002230) | 3.23936625 |
| 109 | positive regulation of alpha-beta T cell activation (GO:0046635) | 3.20441363 |
| 110 | lymphocyte migration (GO:0072676) | 3.20390407 |
| 111 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 3.20144581 |
| 112 | positive regulation of mRNA catabolic process (GO:0061014) | 3.20113549 |
| 113 | negative regulation of cardiac muscle hypertrophy (GO:0010614) | 3.19076641 |
| 114 | regulation of chronic inflammatory response (GO:0002676) | 3.19011651 |
| 115 | T cell proliferation (GO:0042098) | 3.17317496 |
| 116 | regulation of B cell mediated immunity (GO:0002712) | 3.16477626 |
| 117 | natural killer cell differentiation (GO:0001779) | 3.15679167 |
| 118 | regulation of interleukin-4 production (GO:0032673) | 3.13943626 |
| 119 | lymph node development (GO:0048535) | 3.12027358 |
| 120 | regulation of regulatory T cell differentiation (GO:0045589) | 3.10895967 |
| 121 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 3.09760835 |
| 122 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.09155718 |
| 123 | natural killer cell activation (GO:0030101) | 3.08265364 |
| 124 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.07910370 |
| 125 | positive regulation of immunoglobulin production (GO:0002639) | 3.07348432 |
| 126 | NIK/NF-kappaB signaling (GO:0038061) | 3.01661470 |
| 127 | cellular response to interleukin-4 (GO:0071353) | 3.01231854 |
| 128 | positive regulation of macrophage differentiation (GO:0045651) | 3.00211888 |
| 129 | ribosomal small subunit assembly (GO:0000028) | 2.97700070 |
| 130 | regulation of isotype switching (GO:0045191) | 2.97403503 |
| 131 | regulation of immunoglobulin production (GO:0002637) | 2.94617959 |
| 132 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 2.93954764 |
| 133 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 2.93954764 |
| 134 | regulation of defense response to virus by virus (GO:0050690) | 2.91886074 |
| 135 | positive regulation of T cell differentiation (GO:0045582) | 2.90772619 |
| 136 | negative regulation of catenin import into nucleus (GO:0035414) | 2.89264395 |
| 137 | viral transcription (GO:0019083) | 2.88736267 |
| 138 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.88094468 |
| 139 | positive regulation of DNA recombination (GO:0045911) | 2.87969272 |
| 140 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.86510965 |
| 141 | Peyers patch development (GO:0048541) | 2.86510965 |
| 142 | positive regulation of granulocyte differentiation (GO:0030854) | 2.85602337 |
| 143 | negative regulation of muscle hypertrophy (GO:0014741) | 2.81614069 |
| 144 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.81269686 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.30589498 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 7.33244177 |
| 3 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 4.21464884 |
| 4 | * STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 4.08721305 |
| 5 | MYC_22102868_ChIP-Seq_BL_Human | 3.89928561 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.67880682 |
| 7 | MYB_26560356_Chip-Seq_TH2_Human | 3.55993367 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.34919432 |
| 9 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.24097542 |
| 10 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.12259407 |
| 11 | MAF_26560356_Chip-Seq_TH1_Human | 3.00561196 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.99279647 |
| 13 | * UTX_26944678_Chip-Seq_JUKART_Human | 2.88977623 |
| 14 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.84907079 |
| 15 | MYB_26560356_Chip-Seq_TH1_Human | 2.73013466 |
| 16 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.72280241 |
| 17 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.64034774 |
| 18 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.45587329 |
| 19 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.42969632 |
| 20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.41843835 |
| 21 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.39544524 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.33267241 |
| 23 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 2.28943066 |
| 24 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.28381385 |
| 25 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.19359105 |
| 26 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.05928476 |
| 27 | MAF_26560356_Chip-Seq_TH2_Human | 1.97893145 |
| 28 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.90830095 |
| 29 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.82172481 |
| 30 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.75717316 |
| 31 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.72972502 |
| 32 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.71765763 |
| 33 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.65676556 |
| 34 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.64876814 |
| 35 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.62421431 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61057019 |
| 37 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.57015884 |
| 38 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.56386420 |
| 39 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.56247077 |
| 40 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.55234516 |
| 41 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.55083868 |
| 42 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.50664234 |
| 43 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.48325090 |
| 44 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.47273932 |
| 45 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.44721316 |
| 46 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.37342376 |
| 47 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.34763643 |
| 48 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.32067029 |
| 49 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.31343275 |
| 50 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.26333602 |
| 51 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25631923 |
| 52 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.24498526 |
| 53 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.24102776 |
| 54 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.23244286 |
| 55 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.22203558 |
| 56 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.21449559 |
| 57 | * RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.19687243 |
| 58 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.17891599 |
| 59 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.17228032 |
| 60 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.16688141 |
| 61 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.15196773 |
| 62 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.15144959 |
| 63 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14170677 |
| 64 | * GATA3_26560356_Chip-Seq_TH2_Human | 1.10814547 |
| 65 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10583961 |
| 66 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.09513296 |
| 67 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.08087165 |
| 68 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.07947293 |
| 69 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.07423413 |
| 70 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.06602944 |
| 71 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06339129 |
| 72 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.05564930 |
| 73 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.04383566 |
| 74 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.03692644 |
| 75 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.02577294 |
| 76 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.99235190 |
| 77 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.98904019 |
| 78 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.96652761 |
| 79 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.96353874 |
| 80 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.93189565 |
| 81 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92460878 |
| 82 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.92084515 |
| 83 | * GATA3_26560356_Chip-Seq_TH1_Human | 0.90902623 |
| 84 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.90652561 |
| 85 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.90190451 |
| 86 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.89724003 |
| 87 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89450710 |
| 88 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.88812715 |
| 89 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.88631482 |
| 90 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.86647736 |
| 91 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.86102162 |
| 92 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.84067703 |
| 93 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82733839 |
| 94 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.82148027 |
| 95 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.81359328 |
| 96 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.81222888 |
| 97 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.81005787 |
| 98 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.79860251 |
| 99 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.78558685 |
| 100 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.77155670 |
| 101 | GATA1_22025678_ChIP-Seq_K562_Human | 0.76358425 |
| 102 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.76116794 |
| 103 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.75538499 |
| 104 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.75403477 |
| 105 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.74628241 |
| 106 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.74284689 |
| 107 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.73776313 |
| 108 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.73253207 |
| 109 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.72204825 |
| 110 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.72043785 |
| 111 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.72017351 |
| 112 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.71444976 |
| 113 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71338114 |
| 114 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.69893938 |
| 115 | ATF3_27146783_Chip-Seq_COLON_Human | 0.69361180 |
| 116 | FLI1_21867929_ChIP-Seq_CD8_Mouse | 0.68981556 |
| 117 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.68750554 |
| 118 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.68586745 |
| 119 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.68567213 |
| 120 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.68278661 |
| 121 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.68094109 |
| 122 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.68061621 |
| 123 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.67720974 |
| 124 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.67559059 |
| 125 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.67052954 |
| 126 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.67021253 |
| 127 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.66842552 |
| 128 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.66391217 |
| 129 | SPI1_23127762_ChIP-Seq_K562_Human | 0.66383430 |
| 130 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.66355503 |
| 131 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.65791514 |
| 132 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.65615534 |
| 133 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.65197450 |
| 134 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.65105417 |
| 135 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.63612108 |
| 136 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.63599085 |
| 137 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.63353550 |
| 138 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.62132969 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.36476196 |
| 2 | MP0002166_altered_tumor_susceptibility | 4.08793302 |
| 3 | MP0002006_tumorigenesis | 3.94613453 |
| 4 | MP0002009_preneoplasia | 3.84701985 |
| 5 | MP0004381_abnormal_hair_follicle | 3.58778461 |
| 6 | MP0005671_abnormal_response_to | 3.47009033 |
| 7 | MP0002163_abnormal_gland_morphology | 3.22665400 |
| 8 | MP0000685_abnormal_immune_system | 3.12269230 |
| 9 | * MP0000703_abnormal_thymus_morphology | 2.90486816 |
| 10 | MP0003300_gastrointestinal_ulcer | 2.82432219 |
| 11 | MP0004947_skin_inflammation | 2.79800445 |
| 12 | * MP0002398_abnormal_bone_marrow | 2.54640649 |
| 13 | MP0001800_abnormal_humoral_immune | 2.53524373 |
| 14 | MP0005000_abnormal_immune_tolerance | 2.50040361 |
| 15 | MP0009333_abnormal_splenocyte_physiolog | 2.42649659 |
| 16 | MP0001819_abnormal_immune_cell | 2.35909234 |
| 17 | MP0002723_abnormal_immune_serum | 2.35069156 |
| 18 | MP0002420_abnormal_adaptive_immunity | 2.33629296 |
| 19 | MP0001790_abnormal_immune_system | 2.24340701 |
| 20 | MP0005387_immune_system_phenotype | 2.24340701 |
| 21 | MP0005025_abnormal_response_to | 2.21540174 |
| 22 | * MP0002722_abnormal_immune_system | 2.21051445 |
| 23 | MP0001835_abnormal_antigen_presentation | 2.19283288 |
| 24 | MP0000716_abnormal_immune_system | 2.18669752 |
| 25 | MP0006082_CNS_inflammation | 2.17078393 |
| 26 | MP0002405_respiratory_system_inflammati | 2.06104760 |
| 27 | MP0001873_stomach_inflammation | 2.04868937 |
| 28 | MP0002452_abnormal_antigen_presenting | 1.99035820 |
| 29 | MP0002132_abnormal_respiratory_system | 1.98690909 |
| 30 | MP0003866_abnormal_defecation | 1.97085310 |
| 31 | MP0001851_eye_inflammation | 1.95915132 |
| 32 | * MP0000689_abnormal_spleen_morphology | 1.93449016 |
| 33 | MP0003724_increased_susceptibility_to | 1.90224952 |
| 34 | MP0003787_abnormal_imprinting | 1.89609962 |
| 35 | MP0009785_altered_susceptibility_to | 1.85697328 |
| 36 | MP0002148_abnormal_hypersensitivity_rea | 1.85170396 |
| 37 | MP0005310_abnormal_salivary_gland | 1.78649465 |
| 38 | MP0010155_abnormal_intestine_physiology | 1.71333352 |
| 39 | MP0002098_abnormal_vibrissa_morphology | 1.70658962 |
| 40 | MP0002429_abnormal_blood_cell | 1.67260871 |
| 41 | MP0002933_joint_inflammation | 1.65421828 |
| 42 | MP0005379_endocrine/exocrine_gland_phen | 1.61960961 |
| 43 | MP0001533_abnormal_skeleton_physiology | 1.60208328 |
| 44 | MP0002396_abnormal_hematopoietic_system | 1.59850897 |
| 45 | MP0001348_abnormal_lacrimal_gland | 1.51663681 |
| 46 | MP0005464_abnormal_platelet_physiology | 1.50704429 |
| 47 | MP0001853_heart_inflammation | 1.33007401 |
| 48 | MP0003136_yellow_coat_color | 1.31348774 |
| 49 | MP0001845_abnormal_inflammatory_respons | 1.30105363 |
| 50 | MP0000490_abnormal_crypts_of | 1.28452159 |
| 51 | MP0003436_decreased_susceptibility_to | 1.27885539 |
| 52 | MP0003045_fibrosis | 1.23434155 |
| 53 | MP0000858_altered_metastatic_potential | 1.18605468 |
| 54 | MP0003448_altered_tumor_morphology | 1.17145426 |
| 55 | MP0008057_abnormal_DNA_replication | 1.15864728 |
| 56 | MP0002419_abnormal_innate_immunity | 1.15619292 |
| 57 | MP0005075_abnormal_melanosome_morpholog | 1.11963831 |
| 58 | MP0001919_abnormal_reproductive_system | 1.10710728 |
| 59 | MP0008877_abnormal_DNA_methylation | 1.09072265 |
| 60 | MP0000372_irregular_coat_pigmentation | 1.06777115 |
| 61 | MP0004883_abnormal_blood_vessel | 1.01873067 |
| 62 | MP0002277_abnormal_respiratory_mucosa | 1.00411810 |
| 63 | MP0004510_myositis | 0.99814362 |
| 64 | MP0002796_impaired_skin_barrier | 0.98343613 |
| 65 | MP0002019_abnormal_tumor_incidence | 0.97265036 |
| 66 | MP0000569_abnormal_digit_pigmentation | 0.96671827 |
| 67 | MP0000627_abnormal_mammary_gland | 0.96135184 |
| 68 | MP0000367_abnormal_coat/_hair | 0.90610100 |
| 69 | MP0001216_abnormal_epidermal_layer | 0.90028094 |
| 70 | MP0002877_abnormal_melanocyte_morpholog | 0.89926845 |
| 71 | MP0003303_peritoneal_inflammation | 0.87028449 |
| 72 | MP0009278_abnormal_bone_marrow | 0.86713336 |
| 73 | MP0005451_abnormal_body_composition | 0.84557270 |
| 74 | MP0001243_abnormal_dermal_layer | 0.83815721 |
| 75 | MP0002138_abnormal_hepatobiliary_system | 0.83602458 |
| 76 | MP0003091_abnormal_cell_migration | 0.83451603 |
| 77 | MP0004130_abnormal_muscle_cell | 0.81374728 |
| 78 | MP0002876_abnormal_thyroid_physiology | 0.80263878 |
| 79 | MP0000604_amyloidosis | 0.78424857 |
| 80 | MP0005023_abnormal_wound_healing | 0.77811250 |
| 81 | MP0000609_abnormal_liver_physiology | 0.77204208 |
| 82 | MP0008469_abnormal_protein_level | 0.75949927 |
| 83 | MP0001881_abnormal_mammary_gland | 0.74702074 |
| 84 | MP0002693_abnormal_pancreas_physiology | 0.72756526 |
| 85 | MP0003828_pulmonary_edema | 0.69120884 |
| 86 | MP0004808_abnormal_hematopoietic_stem | 0.68937245 |
| 87 | MP0000465_gastrointestinal_hemorrhage | 0.68926703 |
| 88 | MP0000477_abnormal_intestine_morphology | 0.68845536 |
| 89 | MP0003795_abnormal_bone_structure | 0.64822907 |
| 90 | MP0005390_skeleton_phenotype | 0.64263315 |
| 91 | MP0008961_abnormal_basal_metabolism | 0.63182393 |
| 92 | MP0009763_increased_sensitivity_to | 0.63020042 |
| 93 | MP0001545_abnormal_hematopoietic_system | 0.62170380 |
| 94 | MP0005397_hematopoietic_system_phenotyp | 0.62170380 |
| 95 | MP0000750_abnormal_muscle_regeneration | 0.62055632 |
| 96 | MP0002928_abnormal_bile_duct | 0.60417820 |
| 97 | MP0001663_abnormal_digestive_system | 0.57900830 |
| 98 | MP0002998_abnormal_bone_remodeling | 0.57258820 |
| 99 | MP0000249_abnormal_blood_vessel | 0.57146397 |
| 100 | MP0001346_abnormal_lacrimal_gland | 0.56908793 |
| 101 | MP0008260_abnormal_autophagy | 0.56342020 |
| 102 | MP0009764_decreased_sensitivity_to | 0.56313749 |
| 103 | MP0005076_abnormal_cell_differentiation | 0.55782997 |
| 104 | MP0002060_abnormal_skin_morphology | 0.55668854 |
| 105 | MP0002136_abnormal_kidney_physiology | 0.54760317 |
| 106 | MP0010234_abnormal_vibrissa_follicle | 0.54706575 |
| 107 | MP0009931_abnormal_skin_appearance | 0.54617010 |
| 108 | MP0003453_abnormal_keratinocyte_physiol | 0.53773178 |
| 109 | MP0008872_abnormal_physiological_respon | 0.53749489 |
| 110 | MP0009765_abnormal_xenobiotic_induced | 0.53275365 |
| 111 | MP0003786_premature_aging | 0.52547238 |
| 112 | MP0003959_abnormal_lean_body | 0.51624824 |
| 113 | MP0001340_abnormal_eyelid_morphology | 0.51213208 |
| 114 | MP0001501_abnormal_sleep_pattern | 0.50814168 |
| 115 | MP0001502_abnormal_circadian_rhythm | 0.49625281 |
| 116 | MP0001191_abnormal_skin_condition | 0.48965812 |
| 117 | MP0008873_increased_physiological_sensi | 0.48450517 |
| 118 | MP0003656_abnormal_erythrocyte_physiolo | 0.47962481 |
| 119 | MP0001765_abnormal_ion_homeostasis | 0.47632951 |
| 120 | MP0005365_abnormal_bile_salt | 0.47088455 |
| 121 | MP0003252_abnormal_bile_duct | 0.45981749 |
| 122 | MP0005645_abnormal_hypothalamus_physiol | 0.45213916 |
| 123 | MP0001986_abnormal_taste_sensitivity | 0.44944500 |
| 124 | MP0005166_decreased_susceptibility_to | 0.44569489 |
| 125 | MP0000015_abnormal_ear_pigmentation | 0.40396132 |
| 126 | MP0004185_abnormal_adipocyte_glucose | 0.39031698 |
| 127 | MP0005389_reproductive_system_phenotype | 0.37243608 |
| 128 | MP0003172_abnormal_lysosome_physiology | 0.36633238 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Stomatitis (HP:0010280) | 9.41695804 |
| 2 | Abnormality of T cell number (HP:0011839) | 7.43484740 |
| 3 | T lymphocytopenia (HP:0005403) | 6.82057317 |
| 4 | Elevated erythrocyte sedimentation rate (HP:0003565) | 6.53159473 |
| 5 | Severe combined immunodeficiency (HP:0004430) | 5.48030842 |
| 6 | Eosinophilia (HP:0001880) | 5.17895479 |
| 7 | Abnormality of B cell number (HP:0010975) | 5.12816311 |
| 8 | B lymphocytopenia (HP:0010976) | 5.12816311 |
| 9 | Combined immunodeficiency (HP:0005387) | 4.98551873 |
| 10 | Abnormality of T cells (HP:0002843) | 4.71626217 |
| 11 | Abnormality of eosinophils (HP:0001879) | 4.45006894 |
| 12 | IgG deficiency (HP:0004315) | 4.38464567 |
| 13 | Myositis (HP:0100614) | 4.27341399 |
| 14 | Granulocytopenia (HP:0001913) | 4.14835874 |
| 15 | Increased IgM level (HP:0003496) | 4.12183420 |
| 16 | Hypoplasia of the thymus (HP:0000778) | 3.99379476 |
| 17 | Panhypogammaglobulinemia (HP:0003139) | 3.95534163 |
| 18 | Autoimmune thrombocytopenia (HP:0001973) | 3.81347944 |
| 19 | Retrobulbar optic neuritis (HP:0100654) | 3.79515913 |
| 20 | Optic neuritis (HP:0100653) | 3.79515913 |
| 21 | Thyroiditis (HP:0100646) | 3.74016002 |
| 22 | Recurrent viral infections (HP:0004429) | 3.71409512 |
| 23 | Recurrent fungal infections (HP:0002841) | 3.57633807 |
| 24 | Leukocytosis (HP:0001974) | 3.56538210 |
| 25 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.55342495 |
| 26 | Muscle fiber atrophy (HP:0100295) | 3.55138732 |
| 27 | IgM deficiency (HP:0002850) | 3.54348360 |
| 28 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.38107813 |
| 29 | Recurrent bronchitis (HP:0002837) | 3.37904455 |
| 30 | Lymphopenia (HP:0001888) | 3.28940586 |
| 31 | Abnormal pupillary function (HP:0007686) | 3.26601073 |
| 32 | Orchitis (HP:0100796) | 3.24969876 |
| 33 | Joint swelling (HP:0001386) | 3.13434276 |
| 34 | Alveolar cell carcinoma (HP:0006519) | 3.05369229 |
| 35 | Pustule (HP:0200039) | 3.01911948 |
| 36 | Recurrent bacterial skin infections (HP:0005406) | 2.95442028 |
| 37 | Stomach cancer (HP:0012126) | 2.91321383 |
| 38 | Abnormality of T cell physiology (HP:0011840) | 2.87995491 |
| 39 | Agammaglobulinemia (HP:0004432) | 2.84068493 |
| 40 | Recurrent abscess formation (HP:0002722) | 2.76250994 |
| 41 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.75068634 |
| 42 | Vasculitis (HP:0002633) | 2.71487808 |
| 43 | Recurrent skin infections (HP:0001581) | 2.67988684 |
| 44 | Oligodontia (HP:0000677) | 2.62750094 |
| 45 | Gastrointestinal infarctions (HP:0005244) | 2.61830364 |
| 46 | Keratoconjunctivitis sicca (HP:0001097) | 2.61520224 |
| 47 | Eczematoid dermatitis (HP:0000976) | 2.59626235 |
| 48 | Pulmonary infiltrates (HP:0002113) | 2.55370568 |
| 49 | Abnormality of the fingertips (HP:0001211) | 2.53293182 |
| 50 | Inflammation of the large intestine (HP:0002037) | 2.52067216 |
| 51 | Hypergammaglobulinemia (HP:0010702) | 2.49539960 |
| 52 | Prostate neoplasm (HP:0100787) | 2.47313748 |
| 53 | Hypochromic anemia (HP:0001931) | 2.45509121 |
| 54 | Hypoproteinemia (HP:0003075) | 2.45478410 |
| 55 | Lymphoma (HP:0002665) | 2.44671551 |
| 56 | Meningitis (HP:0001287) | 2.44004995 |
| 57 | Arterial thrombosis (HP:0004420) | 2.42338627 |
| 58 | Keratoconjunctivitis (HP:0001096) | 2.33755708 |
| 59 | Gastrointestinal inflammation (HP:0004386) | 2.33224122 |
| 60 | Chronic otitis media (HP:0000389) | 2.29754907 |
| 61 | Supernumerary ribs (HP:0005815) | 2.27165281 |
| 62 | Achilles tendon contracture (HP:0001771) | 2.26760815 |
| 63 | Obstructive lung disease (HP:0006536) | 2.26427968 |
| 64 | Chronic obstructive pulmonary disease (HP:0006510) | 2.26427968 |
| 65 | Mediastinal lymphadenopathy (HP:0100721) | 2.26097673 |
| 66 | Chest pain (HP:0100749) | 2.26042586 |
| 67 | Chronic diarrhea (HP:0002028) | 2.24976701 |
| 68 | Nasal polyposis (HP:0100582) | 2.19591573 |
| 69 | Hemoptysis (HP:0002105) | 2.19400124 |
| 70 | Areflexia of lower limbs (HP:0002522) | 2.17554761 |
| 71 | Premature skin wrinkling (HP:0100678) | 2.16939246 |
| 72 | Abnormality of macrophages (HP:0004311) | 2.15247608 |
| 73 | Abnormality of the Achilles tendon (HP:0005109) | 2.11762698 |
| 74 | IgA deficiency (HP:0002720) | 2.11204820 |
| 75 | Colitis (HP:0002583) | 2.09504945 |
| 76 | Recurrent cutaneous fungal infections (HP:0011370) | 2.07837908 |
| 77 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.07837908 |
| 78 | Encephalitis (HP:0002383) | 2.05863265 |
| 79 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.05178715 |
| 80 | Recurrent otitis media (HP:0000403) | 2.03983599 |
| 81 | Autoimmune hemolytic anemia (HP:0001890) | 12.2711110 |
| 82 | Abnormality of the pleura (HP:0002103) | 1.98800672 |
| 83 | Acute hepatic failure (HP:0006554) | 1.97769110 |
| 84 | Papilledema (HP:0001085) | 1.96465788 |
| 85 | Basal cell carcinoma (HP:0002671) | 1.96165762 |
| 86 | Thrombocytosis (HP:0001894) | 1.95537600 |
| 87 | Neutropenia (HP:0001875) | 1.95198123 |
| 88 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.93883473 |
| 89 | Abnormality of the prostate (HP:0008775) | 1.93840200 |
| 90 | Anorexia (HP:0002039) | 1.92831526 |
| 91 | Pulmonary embolism (HP:0002204) | 1.91478469 |
| 92 | Gingivitis (HP:0000230) | 1.91435452 |
| 93 | Fatigue (HP:0012378) | 1.87504949 |
| 94 | Gangrene (HP:0100758) | 1.87292793 |
| 95 | Vertebral arch anomaly (HP:0008438) | 1.86651100 |
| 96 | Papilloma (HP:0012740) | 1.85333773 |
| 97 | Verrucae (HP:0200043) | 1.85333773 |
| 98 | Sepsis (HP:0100806) | 1.82572404 |
| 99 | Atrioventricular block (HP:0001678) | 1.82558234 |
| 100 | Abnormal number of incisors (HP:0011064) | 1.81605214 |
| 101 | Abnormality of the nasal mucosa (HP:0000433) | 1.80745854 |
| 102 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.79423748 |
| 103 | Keratitis (HP:0000491) | 1.79266437 |
| 104 | Bronchitis (HP:0012387) | 1.78596396 |
| 105 | Fair hair (HP:0002286) | 1.78541305 |
| 106 | Episodic fever (HP:0001954) | 1.77192811 |
| 107 | Submucous cleft hard palate (HP:0000176) | 1.77144206 |
| 108 | Epistaxis (HP:0000421) | 1.76243760 |
| 109 | Aplastic anemia (HP:0001915) | 1.74545066 |
| 110 | Recurrent sinusitis (HP:0011108) | 1.70718624 |
| 111 | Pulmonary fibrosis (HP:0002206) | 1.70417399 |
| 112 | Skin rash (HP:0000988) | 1.70136189 |
| 113 | Abnormality of male internal genitalia (HP:0000022) | 1.69221452 |
| 114 | Abnormal number of erythroid precursors (HP:0012131) | 1.67825979 |
| 115 | Increased IgE level (HP:0003212) | 1.66030125 |
| 116 | Prolonged bleeding time (HP:0003010) | 1.65566150 |
| 117 | Slow saccadic eye movements (HP:0000514) | 1.62591000 |
| 118 | Increased density of long bones (HP:0006392) | 1.61494983 |
| 119 | Gastrointestinal stroma tumor (HP:0100723) | 1.61276348 |
| 120 | Pancytopenia (HP:0001876) | 1.61083274 |
| 121 | Hematochezia (HP:0002573) | 1.61026700 |
| 122 | Reticulocytopenia (HP:0001896) | 1.60069198 |
| 123 | Arthralgia (HP:0002829) | 1.58750774 |
| 124 | Erythema (HP:0010783) | 1.57585420 |
| 125 | Spontaneous hematomas (HP:0007420) | 1.56542815 |
| 126 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.55039016 |
| 127 | Concave nail (HP:0001598) | 1.54430604 |
| 128 | Anhidrosis (HP:0000970) | 1.51170698 |
| 129 | Type I diabetes mellitus (HP:0100651) | 1.51073709 |
| 130 | Abnormality of oral frenula (HP:0000190) | 1.50898919 |
| 131 | Persistence of primary teeth (HP:0006335) | 1.49378006 |
| 132 | Glomerulopathy (HP:0100820) | 1.49029417 |
| 133 | Sparse scalp hair (HP:0002209) | 1.48963986 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 5.25078855 |
| 2 | MAP4K1 | 5.22859881 |
| 3 | BRD4 | 4.23759929 |
| 4 | ITK | 3.39131865 |
| 5 | ZAP70 | 3.29241673 |
| 6 | TAOK3 | 2.83867431 |
| 7 | MST4 | 2.72845490 |
| 8 | FGFR4 | 2.52498685 |
| 9 | EPHA3 | 2.48861268 |
| 10 | EEF2K | 2.21647413 |
| 11 | STK10 | 2.19727124 |
| 12 | CAMKK2 | 2.17224970 |
| 13 | IKBKE | 2.12228102 |
| 14 | GRK6 | 2.06733668 |
| 15 | MAP3K14 | 2.01671704 |
| 16 | TEC | 2.00926486 |
| 17 | RIPK1 | 1.96976879 |
| 18 | RIPK4 | 1.95055374 |
| 19 | EPHB1 | 1.94017471 |
| 20 | CDK4 | 1.85618143 |
| 21 | TBK1 | 1.85100104 |
| 22 | LCK | 1.82372322 |
| 23 | JAK3 | 1.81627682 |
| 24 | SYK | 1.61173585 |
| 25 | PASK | 1.59786914 |
| 26 | HCK | 1.58408449 |
| 27 | TYK2 | 1.57755709 |
| 28 | NLK | 1.51205012 |
| 29 | TNK2 | 1.47934854 |
| 30 | CDK3 | 1.44906763 |
| 31 | SIK3 | 1.44469456 |
| 32 | FGFR3 | 1.43840492 |
| 33 | DAPK2 | 1.43424655 |
| 34 | CSK | 1.41523812 |
| 35 | MAP3K10 | 1.41401141 |
| 36 | DYRK1B | 1.37673489 |
| 37 | BTK | 1.33704216 |
| 38 | TAOK1 | 1.31500641 |
| 39 | CAMKK1 | 1.29432729 |
| 40 | MARK3 | 1.26586668 |
| 41 | CDK6 | 1.25581901 |
| 42 | LRRK2 | 1.22242285 |
| 43 | BCR | 1.15317434 |
| 44 | DYRK3 | 1.15221764 |
| 45 | MAP2K2 | 1.13129702 |
| 46 | MAP3K7 | 1.11129103 |
| 47 | PRKCQ | 1.09232525 |
| 48 | JAK1 | 1.06706020 |
| 49 | MAP2K3 | 1.06019832 |
| 50 | KDR | 1.04288815 |
| 51 | IRAK1 | 1.03132679 |
| 52 | MAPK11 | 1.02524829 |
| 53 | PRKCH | 1.00555219 |
| 54 | MAP3K11 | 0.98039333 |
| 55 | GRK7 | 0.93840821 |
| 56 | IKBKB | 0.91615656 |
| 57 | BLK | 0.89522939 |
| 58 | FYN | 0.89501981 |
| 59 | CDK9 | 0.89137950 |
| 60 | PIM1 | 0.87786111 |
| 61 | NTRK2 | 0.87373030 |
| 62 | FGFR2 | 0.83030286 |
| 63 | MAP3K13 | 0.81058225 |
| 64 | CLK1 | 0.80386422 |
| 65 | MAP3K3 | 0.79152004 |
| 66 | HIPK2 | 0.77029901 |
| 67 | PDGFRB | 0.76668550 |
| 68 | STK4 | 0.75972827 |
| 69 | BMPR2 | 0.72943615 |
| 70 | RPS6KB1 | 0.71497385 |
| 71 | CHUK | 0.69779109 |
| 72 | MAP2K6 | 0.68952135 |
| 73 | MAPK7 | 0.67991981 |
| 74 | PIK3CG | 0.66656163 |
| 75 | IGF1R | 0.65892879 |
| 76 | RPS6KB2 | 0.65784815 |
| 77 | SCYL2 | 0.65180412 |
| 78 | LYN | 0.64690264 |
| 79 | JAK2 | 0.62877558 |
| 80 | ADRBK2 | 0.62695414 |
| 81 | TYRO3 | 0.61183859 |
| 82 | INSR | 0.60506782 |
| 83 | NUAK1 | 0.57467447 |
| 84 | MAP3K1 | 0.56708371 |
| 85 | FGFR1 | 0.56269935 |
| 86 | KIT | 0.55267609 |
| 87 | FES | 0.53917664 |
| 88 | MAP3K12 | 0.53669666 |
| 89 | MAPKAPK3 | 0.50908849 |
| 90 | NME2 | 0.49900262 |
| 91 | CDK12 | 0.49278193 |
| 92 | PIK3CA | 0.49248746 |
| 93 | TAOK2 | 0.49231160 |
| 94 | NEK6 | 0.49127904 |
| 95 | PKN2 | 0.47706806 |
| 96 | CDK8 | 0.44976102 |
| 97 | AURKB | 0.42431632 |
| 98 | TESK2 | 0.42279855 |
| 99 | MARK2 | 0.41649982 |
| 100 | TGFBR2 | 0.41412548 |
| 101 | PRPF4B | 0.41344615 |
| 102 | SIK2 | 0.39653430 |
| 103 | CAMK2G | 0.38621171 |
| 104 | IRAK4 | 0.38619210 |
| 105 | TLK1 | 0.38610408 |
| 106 | CAMK4 | 0.38326131 |
| 107 | PRKCB | 0.38145370 |
| 108 | MAPKAPK2 | 0.37190178 |
| 109 | RPS6KA4 | 0.36816101 |
| 110 | NEK2 | 0.36657490 |
| 111 | CAMK2D | 0.34732768 |
| 112 | SGK2 | 0.34439552 |
| 113 | GSK3A | 0.34344402 |
| 114 | RPS6KA5 | 0.34227183 |
| 115 | SGK3 | 0.32121084 |
| 116 | MAPK4 | 0.30831213 |
| 117 | ERBB3 | 0.30486815 |
| 118 | AURKA | 0.28808190 |
| 119 | RAF1 | 0.28622352 |
| 120 | MAPK12 | 0.28295549 |
| 121 | EIF2AK3 | 0.26022879 |
| 122 | TSSK6 | 0.24830963 |
| 123 | VRK1 | 0.23883139 |
| 124 | CSF1R | 0.23541477 |
| 125 | FER | 0.22974096 |
| 126 | CDK7 | 0.22811493 |
| 127 | ABL1 | 0.22651116 |
| 128 | RET | 0.22229104 |
| 129 | TRPM7 | 0.21958317 |
| 130 | PDK1 | 0.21923891 |
| 131 | MAPK3 | 0.21759514 |
| 132 | CSNK1D | 0.21094672 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.96799839 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 5.46123517 |
| 3 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.67273543 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.36185307 |
| 5 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 3.14474864 |
| 6 | Measles_Homo sapiens_hsa05162 | 3.09948240 |
| 7 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.64447338 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.62686498 |
| 9 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.47088675 |
| 10 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.38015402 |
| 11 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.14526827 |
| 12 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.08274439 |
| 13 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.88382331 |
| 14 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.61130633 |
| 15 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.49532185 |
| 16 | Ribosome_Homo sapiens_hsa03010 | 1.46518990 |
| 17 | HTLV-I infection_Homo sapiens_hsa05166 | 1.44816752 |
| 18 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.39178878 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.38652365 |
| 20 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.33232188 |
| 21 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.32916335 |
| 22 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.32669713 |
| 23 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.25356117 |
| 24 | Leishmaniasis_Homo sapiens_hsa05140 | 1.21706740 |
| 25 | Asthma_Homo sapiens_hsa05310 | 1.18123243 |
| 26 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.14533383 |
| 27 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.07509649 |
| 28 | Viral myocarditis_Homo sapiens_hsa05416 | 1.04766024 |
| 29 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.00766382 |
| 30 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.00412781 |
| 31 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.98421802 |
| 32 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.97762887 |
| 33 | Platelet activation_Homo sapiens_hsa04611 | 0.97550632 |
| 34 | Hepatitis B_Homo sapiens_hsa05161 | 0.96137776 |
| 35 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.96077784 |
| 36 | Bladder cancer_Homo sapiens_hsa05219 | 0.95787798 |
| 37 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.89610329 |
| 38 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.86241474 |
| 39 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.84933820 |
| 40 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.82920543 |
| 41 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.82326178 |
| 42 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.81258706 |
| 43 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.77271973 |
| 44 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.76933301 |
| 45 | Colorectal cancer_Homo sapiens_hsa05210 | 0.75615940 |
| 46 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.72771207 |
| 47 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.72231256 |
| 48 | Apoptosis_Homo sapiens_hsa04210 | 0.71286178 |
| 49 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.71152730 |
| 50 | Shigellosis_Homo sapiens_hsa05131 | 0.70820592 |
| 51 | Influenza A_Homo sapiens_hsa05164 | 0.70288347 |
| 52 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.69452303 |
| 53 | Olfactory transduction_Homo sapiens_hsa04740 | 0.69149329 |
| 54 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.68489977 |
| 55 | RNA degradation_Homo sapiens_hsa03018 | 0.66431152 |
| 56 | Hepatitis C_Homo sapiens_hsa05160 | 0.66268046 |
| 57 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.65517275 |
| 58 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.58710310 |
| 59 | Circadian rhythm_Homo sapiens_hsa04710 | 0.56306674 |
| 60 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.55303010 |
| 61 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.54735783 |
| 62 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.53614569 |
| 63 | Spliceosome_Homo sapiens_hsa03040 | 0.52603010 |
| 64 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.52574015 |
| 65 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.51053871 |
| 66 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.50790417 |
| 67 | Adherens junction_Homo sapiens_hsa04520 | 0.48685322 |
| 68 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.47811965 |
| 69 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.47318863 |
| 70 | Pertussis_Homo sapiens_hsa05133 | 0.46392410 |
| 71 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.45569633 |
| 72 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.44701959 |
| 73 | Thyroid cancer_Homo sapiens_hsa05216 | 0.39944984 |
| 74 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.39404461 |
| 75 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.39070624 |
| 76 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.38099864 |
| 77 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.38021966 |
| 78 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.36899495 |
| 79 | Salmonella infection_Homo sapiens_hsa05132 | 0.36448523 |
| 80 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.35458203 |
| 81 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.34266047 |
| 82 | Prostate cancer_Homo sapiens_hsa05215 | 0.32894518 |
| 83 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.31787523 |
| 84 | Renin secretion_Homo sapiens_hsa04924 | 0.31222733 |
| 85 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.31117350 |
| 86 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.30357194 |
| 87 | Pathways in cancer_Homo sapiens_hsa05200 | 0.30248524 |
| 88 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.29026677 |
| 89 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.28639177 |
| 90 | Malaria_Homo sapiens_hsa05144 | 0.28388907 |
| 91 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.28282677 |
| 92 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.28018316 |
| 93 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.27932853 |
| 94 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.27905047 |
| 95 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.27481544 |
| 96 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.26959940 |
| 97 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.25788051 |
| 98 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.25649277 |
| 99 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.24390202 |
| 100 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.24271544 |
| 101 | Endocytosis_Homo sapiens_hsa04144 | 0.23077743 |
| 102 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.22661478 |
| 103 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.22631629 |
| 104 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.22305343 |
| 105 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.21926666 |
| 106 | Long-term potentiation_Homo sapiens_hsa04720 | 0.21207413 |
| 107 | Endometrial cancer_Homo sapiens_hsa05213 | 0.20689323 |
| 108 | Tuberculosis_Homo sapiens_hsa05152 | 0.18929447 |
| 109 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.18922415 |
| 110 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.18785597 |
| 111 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.18457979 |
| 112 | Insulin resistance_Homo sapiens_hsa04931 | 0.17976766 |
| 113 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.17150956 |
| 114 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.16680138 |
| 115 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.15906441 |
| 116 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.14402279 |
| 117 | Legionellosis_Homo sapiens_hsa05134 | 0.13225128 |
| 118 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.13158730 |
| 119 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.12921872 |
| 120 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.11907174 |
| 121 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.11097732 |
| 122 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.10803176 |
| 123 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.10637971 |
| 124 | Proteasome_Homo sapiens_hsa03050 | 0.09896207 |
| 125 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.08445011 |

