TRAV1-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.82962050
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.01209923
3negative thymic T cell selection (GO:0045060)6.95164245
4Arp2/3 complex-mediated actin nucleation (GO:0034314)6.75375485
5positive T cell selection (GO:0043368)6.36908594
6gonadal mesoderm development (GO:0007506)6.35700363
7positive regulation of granulocyte differentiation (GO:0030854)6.26771395
8V(D)J recombination (GO:0033151)6.14891356
9positive regulation of gamma-delta T cell activation (GO:0046645)5.89128032
10mucosal-associated lymphoid tissue development (GO:0048537)5.63537178
11Peyers patch development (GO:0048541)5.63537178
12actin nucleation (GO:0045010)5.52650466
13T cell selection (GO:0045058)5.51922013
14tolerance induction (GO:0002507)5.43974646
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.33566562
16thymic T cell selection (GO:0045061)5.32340168
17regulation of gamma-delta T cell differentiation (GO:0045586)5.14057916
18negative regulation of thymocyte apoptotic process (GO:0070244)5.08255855
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04671131
20regulation of isotype switching to IgG isotypes (GO:0048302)5.00859782
21positive thymic T cell selection (GO:0045059)4.97881531
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89025440
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.87794765
24antigen processing and presentation of endogenous antigen (GO:0019883)4.79334534
25activated T cell proliferation (GO:0050798)4.78652338
26regulation of B cell receptor signaling pathway (GO:0050855)4.76623905
27regulation of gamma-delta T cell activation (GO:0046643)4.52684319
28mature B cell differentiation involved in immune response (GO:0002313)4.52373573
29innate immune response in mucosa (GO:0002227)4.49684149
30leukocyte aggregation (GO:0070486)4.49337769
31negative regulation of myotube differentiation (GO:0010832)4.47102048
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.27488440
33negative regulation of cell killing (GO:0031342)4.27488440
34T cell migration (GO:0072678)4.19950185
35T cell receptor signaling pathway (GO:0050852)4.12198643
36positive regulation of natural killer cell mediated immunity (GO:0002717)4.07560787
37negative regulation of T cell apoptotic process (GO:0070233)3.99876749
38regulation of T cell tolerance induction (GO:0002664)3.99776205
39T cell differentiation (GO:0030217)3.98073541
40regulation of regulatory T cell differentiation (GO:0045589)3.97941259
41regulation of natural killer cell mediated immunity (GO:0002715)3.97896654
42regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.97896654
43cellular response to interleukin-15 (GO:0071350)3.96882091
44alpha-beta T cell differentiation (GO:0046632)3.96677339
45positive regulation of alpha-beta T cell proliferation (GO:0046641)3.96301405
46regulation of granulocyte differentiation (GO:0030852)3.96166440
47regulation of alpha-beta T cell proliferation (GO:0046640)3.92836074
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.90875705
49regulation of T cell receptor signaling pathway (GO:0050856)3.90582017
50antigen receptor-mediated signaling pathway (GO:0050851)3.89520662
51positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.84851101
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.83273161
53CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.77716097
54T-helper cell differentiation (GO:0042093)3.77716097
55positive regulation of T cell differentiation in thymus (GO:0033089)3.76653906
56mature B cell differentiation (GO:0002335)3.74953349
57mucosal immune response (GO:0002385)3.73721456
58execution phase of apoptosis (GO:0097194)3.70294339
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.69918824
60response to interleukin-15 (GO:0070672)3.68556398
61negative regulation of stress fiber assembly (GO:0051497)3.68195980
62positive regulation of tolerance induction (GO:0002645)3.62596668
63alpha-beta T cell activation (GO:0046631)3.61633247
64T cell costimulation (GO:0031295)3.60989064
65lymphocyte costimulation (GO:0031294)3.57450180
66regulation of interleukin-4 production (GO:0032673)3.55659331
67modulation by host of symbiont transcription (GO:0052472)3.54126519
68modulation by host of viral transcription (GO:0043921)3.54126519
69organ or tissue specific immune response (GO:0002251)3.52676915
70regulation of defense response to virus by virus (GO:0050690)3.47243742
71antibacterial humoral response (GO:0019731)3.42350207
72B cell receptor signaling pathway (GO:0050853)3.40797266
73positive regulation of isotype switching (GO:0045830)3.40660834
74T cell differentiation involved in immune response (GO:0002292)3.35429171
75alpha-beta T cell differentiation involved in immune response (GO:0002293)3.35429171
76alpha-beta T cell activation involved in immune response (GO:0002287)3.35429171
77modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.28769904
78regulation of tolerance induction (GO:0002643)3.27771310
79CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.27494710
80negative regulation of T cell mediated immunity (GO:0002710)3.25754860
81T cell activation (GO:0042110)3.24680567
82positive regulation of alpha-beta T cell activation (GO:0046635)3.24603312
83antigen processing and presentation via MHC class Ib (GO:0002475)3.24545499
84regulation of thymocyte apoptotic process (GO:0070243)3.24394015
85positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.23179018
86antimicrobial humoral response (GO:0019730)3.16436038
87positive regulation of calcium-mediated signaling (GO:0050850)3.15860280
88positive regulation of interleukin-4 production (GO:0032753)3.14821522
89positive regulation by host of viral transcription (GO:0043923)3.11464568
90positive regulation of translational initiation (GO:0045948)3.10550504
91positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.07950569
92CD4-positive, alpha-beta T cell activation (GO:0035710)3.07335964
93regulation of alpha-beta T cell activation (GO:0046634)3.05227727
94lymphocyte differentiation (GO:0030098)3.02000924
95positive regulation of DNA recombination (GO:0045911)2.98808697
96negative regulation of bone resorption (GO:0045779)2.98092600
97regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97253491
98positive regulation of alpha-beta T cell differentiation (GO:0046638)2.97073479
99hypothalamus development (GO:0021854)2.96942393
100positive regulation of interleukin-2 production (GO:0032743)2.94394836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.52188233
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.07866001
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.06617531
4E2F7_22180533_ChIP-Seq_HELA_Human4.00188486
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.65263246
6RUNX_20019798_ChIP-Seq_JUKART_Human3.63493260
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.50807087
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23068728
9MYB_26560356_Chip-Seq_TH2_Human3.20927252
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07027486
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.94573762
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67526168
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66095758
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64898972
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63194679
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.51884714
17UTX_26944678_Chip-Seq_JUKART_Human2.51399336
18GATA3_27048872_Chip-Seq_THYMUS_Human2.50729629
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45025370
20MAF_26560356_Chip-Seq_TH1_Human2.40297350
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30814838
22MYB_26560356_Chip-Seq_TH1_Human2.21821532
23MYC_22102868_ChIP-Seq_BL_Human2.19604117
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.13938771
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.12655033
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09372910
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.1196469
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94613360
29RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.84577805
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83918341
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81701826
32SPI1_23547873_ChIP-Seq_NB4_Human1.72416569
33MAF_26560356_Chip-Seq_TH2_Human1.70384718
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69545532
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.64284274
36CIITA_25753668_ChIP-Seq_RAJI_Human1.63832091
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53116806
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51562597
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49112785
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47022594
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46817701
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.44098273
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42596561
44GATA3_26560356_Chip-Seq_TH2_Human1.42119356
45VDR_24763502_ChIP-Seq_THP-1_Human1.41028641
46VDR_23849224_ChIP-Seq_CD4+_Human1.40640195
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38168225
48VDR_21846776_ChIP-Seq_THP-1_Human1.36390082
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35466955
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32390429
51SPI1_23127762_ChIP-Seq_K562_Human1.30623747
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30466752
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29142953
54TCF7_22412390_ChIP-Seq_EML_Mouse1.28723250
55SCL_19346495_ChIP-Seq_HPC-7_Human1.26548752
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26314455
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25350319
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23981847
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21601770
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19526536
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.19472128
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.14109802
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14069372
64FOXP3_21729870_ChIP-Seq_TREG_Human1.11050033
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08685005
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.07953928
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04994498
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04333901
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01944289
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99827333
71SMAD_19615063_ChIP-ChIP_OVARY_Human0.97264423
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97144489
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96937613
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95951296
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95086348
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93574580
77KDM2B_26808549_Chip-Seq_DND41_Human0.93251864
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92978248
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87104120
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84410666
81STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84114313
82E2F1_21310950_ChIP-Seq_MCF-7_Human0.80269203
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79918377
84NELFA_20434984_ChIP-Seq_ESCs_Mouse0.79270688
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77939893
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75588793
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74928716
88TP63_17297297_ChIP-ChIP_HaCaT_Human0.73029825
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.72591086
90ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72349513
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71759925
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.71536790
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70944345
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69528221
95GATA3_26560356_Chip-Seq_TH1_Human0.68909084
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68597761
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67630788
98THAP11_20581084_ChIP-Seq_MESCs_Mouse0.67617290
99BCOR_27268052_Chip-Seq_Bcells_Human0.67106798
100P300_27268052_Chip-Seq_Bcells_Human0.66225600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.04372447
2MP0005671_abnormal_response_to4.00216194
3MP0004381_abnormal_hair_follicle3.73810473
4MP0001835_abnormal_antigen_presentation3.21579943
5MP0001800_abnormal_humoral_immune3.11341044
6MP0002166_altered_tumor_susceptibility3.05910639
7MP0000703_abnormal_thymus_morphology3.01516061
8MP0009785_altered_susceptibility_to2.78194020
9MP0002396_abnormal_hematopoietic_system2.77751947
10MP0003436_decreased_susceptibility_to2.76957046
11MP0005000_abnormal_immune_tolerance2.76370978
12MP0009333_abnormal_splenocyte_physiolog2.70262180
13MP0001790_abnormal_immune_system2.69684822
14MP0005387_immune_system_phenotype2.69684822
15MP0002009_preneoplasia2.69064627
16MP0004147_increased_porphyrin_level2.65672879
17MP0002398_abnormal_bone_marrow2.59056637
18MP0002420_abnormal_adaptive_immunity2.55342252
19MP0001819_abnormal_immune_cell2.48408120
20MP0000685_abnormal_immune_system2.47417885
21MP0002405_respiratory_system_inflammati2.46806770
22MP0002723_abnormal_immune_serum2.45272829
23MP0005025_abnormal_response_to2.34674185
24MP0005075_abnormal_melanosome_morpholog2.32166871
25MP0002452_abnormal_antigen_presenting2.24691604
26MP0002722_abnormal_immune_system2.20508020
27MP0002148_abnormal_hypersensitivity_rea2.17034518
28MP0002006_tumorigenesis2.16993604
29MP0000689_abnormal_spleen_morphology2.11804061
30MP0001873_stomach_inflammation2.11261060
31MP0000716_abnormal_immune_system2.11250571
32MP0003724_increased_susceptibility_to2.07416128
33MP0004947_skin_inflammation2.01929921
34MP0008057_abnormal_DNA_replication1.87756946
35MP0003866_abnormal_defecation1.80474362
36MP0002429_abnormal_blood_cell1.72964777
37MP0005310_abnormal_salivary_gland1.63512962
38MP0002419_abnormal_innate_immunity1.62080238
39MP0010155_abnormal_intestine_physiology1.52459322
40MP0001845_abnormal_inflammatory_respons1.48170628
41MP0009697_abnormal_copulation1.43580475
42MP0002933_joint_inflammation1.43349518
43MP0002132_abnormal_respiratory_system1.40946446
44MP0003300_gastrointestinal_ulcer1.28956051
45MP0005464_abnormal_platelet_physiology1.28873994
46MP0003787_abnormal_imprinting1.22769364
47MP0000015_abnormal_ear_pigmentation1.22637579
48MP0001853_heart_inflammation1.21656793
49MP0008877_abnormal_DNA_methylation1.20702386
50MP0006082_CNS_inflammation1.18796932
51MP0001243_abnormal_dermal_layer1.18439176
52MP0003656_abnormal_erythrocyte_physiolo1.12155400
53MP0004130_abnormal_muscle_cell1.10029847
54MP0000465_gastrointestinal_hemorrhage1.07239484
55MP0004808_abnormal_hematopoietic_stem1.04360593
56MP0000490_abnormal_crypts_of1.01758215
57MP0000858_altered_metastatic_potential1.01506903
58MP0008469_abnormal_protein_level0.97017976
59MP0001919_abnormal_reproductive_system0.91183443
60MP0010094_abnormal_chromosome_stability0.90948563
61MP0003806_abnormal_nucleotide_metabolis0.89587629
62MP0003303_peritoneal_inflammation0.88455911
63MP0009764_decreased_sensitivity_to0.87051469
64MP0002019_abnormal_tumor_incidence0.86507310
65MP0001533_abnormal_skeleton_physiology0.85215189
66MP0002693_abnormal_pancreas_physiology0.83821142
67MP0009763_increased_sensitivity_to0.83123790
68MP0010386_abnormal_urinary_bladder0.82808978
69MP0001851_eye_inflammation0.80575468
70MP0003045_fibrosis0.78951989
71MP0003252_abnormal_bile_duct0.78910302
72MP0003077_abnormal_cell_cycle0.72880583
73MP0003111_abnormal_nucleus_morphology0.69403675
74MP0001663_abnormal_digestive_system0.67107106
75MP0004134_abnormal_chest_morphology0.66330941
76MP0002277_abnormal_respiratory_mucosa0.63640640
77MP0006054_spinal_hemorrhage0.62519324
78MP0009278_abnormal_bone_marrow0.60900335
79MP0000313_abnormal_cell_death0.59069140
80MP0004957_abnormal_blastocyst_morpholog0.58808498
81MP0009765_abnormal_xenobiotic_induced0.58699844
82MP0002877_abnormal_melanocyte_morpholog0.55523584
83MP0003448_altered_tumor_morphology0.52288207
84MP0002163_abnormal_gland_morphology0.52145162
85MP0002998_abnormal_bone_remodeling0.51492804
86MP0002138_abnormal_hepatobiliary_system0.50646912
87MP0001348_abnormal_lacrimal_gland0.48916032
88MP0003786_premature_aging0.48567907
89MP0000371_diluted_coat_color0.47843454
90MP0005266_abnormal_metabolism0.47588826
91MP0005166_decreased_susceptibility_to0.47551532
92MP0005076_abnormal_cell_differentiation0.47355118
93MP0003943_abnormal_hepatobiliary_system0.47243840
94MP0000367_abnormal_coat/_hair0.45562838
95MP0001730_embryonic_growth_arrest0.44978180
96MP0008007_abnormal_cellular_replicative0.44972192
97MP0003221_abnormal_cardiomyocyte_apopto0.42908319
98MP0005389_reproductive_system_phenotype0.42343600
99MP0002083_premature_death0.42245802
100MP0009931_abnormal_skin_appearance0.40823652

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)7.55443924
2Severe combined immunodeficiency (HP:0004430)6.97979326
3Abnormality of B cell number (HP:0010975)6.76600709
4Increased IgM level (HP:0003496)5.94080691
5Combined immunodeficiency (HP:0005387)5.89860028
6Autoimmune hemolytic anemia (HP:0001890)5.63997313
7Thyroiditis (HP:0100646)5.57630483
8T lymphocytopenia (HP:0005403)5.54430954
9IgG deficiency (HP:0004315)5.43290279
10Abnormality of T cell number (HP:0011839)4.85696626
11IgM deficiency (HP:0002850)4.70326347
12Increased IgE level (HP:0003212)4.45717033
13Broad face (HP:0000283)4.24909399
14Eosinophilia (HP:0001880)4.15842713
15Elevated erythrocyte sedimentation rate (HP:0003565)4.13741968
16Panhypogammaglobulinemia (HP:0003139)4.05834114
17Recurrent fungal infections (HP:0002841)4.00455179
18Encephalitis (HP:0002383)3.97981058
19Abnormality of the columella (HP:0009929)3.93839614
20Hypoplasia of the thymus (HP:0000778)3.84641919
21Recurrent viral infections (HP:0004429)3.80412497
22Granulocytopenia (HP:0001913)3.79734398
23Eczematoid dermatitis (HP:0000976)3.67516712
24Abnormality of eosinophils (HP:0001879)3.66094576
25Meningitis (HP:0001287)3.54927566
26Abnormality of T cells (HP:0002843)3.53992862
27Lymphopenia (HP:0001888)3.48819495
28Autoimmune thrombocytopenia (HP:0001973)3.43952654
29Acute hepatic failure (HP:0006554)3.38238669
30Hypergammaglobulinemia (HP:0010702)3.26003204
31Lymphoma (HP:0002665)3.24671618
32Stomatitis (HP:0010280)3.19408739
33Chronic diarrhea (HP:0002028)3.18424868
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.09665725
35Recurrent bronchitis (HP:0002837)3.04493547
36Leukocytosis (HP:0001974)2.96160603
37Gastrointestinal infarctions (HP:0005244)2.93763494
38Spontaneous hematomas (HP:0007420)2.73624929
39Aplasia/Hypoplasia of the thymus (HP:0010515)2.71849430
40Vasculitis (HP:0002633)2.67862211
41Abnormality of the prostate (HP:0008775)2.61012816
42Abnormality of the left ventricular outflow tract (HP:0011103)2.59756229
43Subaortic stenosis (HP:0001682)2.59756229
44Chronic obstructive pulmonary disease (HP:0006510)2.58989194
45Obstructive lung disease (HP:0006536)2.58989194
46IgA deficiency (HP:0002720)2.57334728
47Chest pain (HP:0100749)2.56545892
48Mediastinal lymphadenopathy (HP:0100721)2.54424225
49Short 4th metacarpal (HP:0010044)2.44060149
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44060149
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.41744664
52Abnormality of macrophages (HP:0004311)2.37960385
53Joint swelling (HP:0001386)2.37039341
54Cellular immunodeficiency (HP:0005374)2.36973341
55Pancytopenia (HP:0001876)2.35127152
56Hypoproteinemia (HP:0003075)2.33389469
57Neoplasm of the heart (HP:0100544)2.32510275
58Pulmonary infiltrates (HP:0002113)2.31449128
59Chronic mucocutaneous candidiasis (HP:0002728)2.28621866
60Recurrent cutaneous fungal infections (HP:0011370)2.28621866
61Aplastic anemia (HP:0001915)2.27951358
62Abnormality of the pleura (HP:0002103)2.22134419
63Petechiae (HP:0000967)2.20982055
64High anterior hairline (HP:0009890)2.20788311
65Recurrent abscess formation (HP:0002722)2.16469173
66Hepatitis (HP:0012115)2.15635844
67Myositis (HP:0100614)2.15445806
68Inflammation of the large intestine (HP:0002037)2.08899822
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06812969
70Abnormality of the thymus (HP:0000777)2.06661156
71Gastrointestinal inflammation (HP:0004386)2.04222179
72Abnormality of T cell physiology (HP:0011840)2.04159596
73Cerebral hypomyelination (HP:0006808)1.99509949
74Sepsis (HP:0100806)1.98014828
75Papilledema (HP:0001085)1.96181866
76Vacuolated lymphocytes (HP:0001922)1.94847049
77Basal cell carcinoma (HP:0002671)1.92854923
78Recurrent bacterial skin infections (HP:0005406)1.92466193
79Long nose (HP:0003189)1.90564309
80Pustule (HP:0200039)1.88724547
81Colitis (HP:0002583)1.88279813
82Epistaxis (HP:0000421)1.88211919
83Gangrene (HP:0100758)1.88015546
84Hemoptysis (HP:0002105)1.87247152
85Personality changes (HP:0000751)1.85212030
86Nephroblastoma (Wilms tumor) (HP:0002667)1.83223499
87Microcytic anemia (HP:0001935)1.80972206
88Premature ovarian failure (HP:0008209)1.80578953
89Hypochromic microcytic anemia (HP:0004840)1.80270199
903-Methylglutaconic aciduria (HP:0003535)1.79774163
91Pulmonary embolism (HP:0002204)1.78317517
92Cupped ribs (HP:0000887)1.76546546
93Mesangial abnormality (HP:0001966)1.74493090
94Amaurosis fugax (HP:0100576)1.72310959
95Optic neuritis (HP:0100653)1.71952579
96Retrobulbar optic neuritis (HP:0100654)1.71952579
97Orchitis (HP:0100796)1.70612796
98Keratoconjunctivitis sicca (HP:0001097)1.70462591
99Embryonal renal neoplasm (HP:0011794)1.67995959
100Cutis marmorata (HP:0000965)1.66892429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.19438754
2MAP3K124.11505546
3MAP4K13.95586580
4MAP3K103.58621688
5TXK3.54531600
6NLK3.42851169
7BLK3.25650492
8TLK13.22957437
9BUB12.66795625
10CAMKK22.58763899
11ITK2.48777598
12KDR2.30820901
13ZAK1.98278713
14VRK11.94617577
15ZAP701.94613761
16FES1.85732153
17BTK1.76977179
18RPS6KA51.68476925
19CSK1.67433573
20MAP3K111.63529231
21SYK1.53217656
22SCYL21.47207042
23TYK21.40699409
24PRPF4B1.38225798
25LCK1.37146486
26TESK11.33270259
27ACVR1B1.26078675
28CDK121.24351930
29TYRO31.21433969
30CAMKK11.21240806
31MAPK111.18598863
32MAP3K31.13058488
33GRK61.11428202
34HCK1.07415786
35RIPK41.05796264
36ICK1.04448530
37TEC1.03532093
38LYN1.02007091
39CLK11.00559253
40DAPK30.99873490
41RPS6KA40.99754404
42PRKCQ0.98623176
43PIM10.96973422
44STK100.94869968
45JAK10.93867081
46EIF2AK10.91113263
47MELK0.84995108
48CDK60.83245804
49MAP3K50.81671658
50TAOK10.78852483
51JAK30.76702724
52STK40.74792466
53TNK20.73824152
54CDK40.72080272
55HIPK20.70295429
56FGFR40.68499677
57TAOK20.65728509
58MAP3K70.65193433
59SMG10.64693073
60SIK30.63523304
61MAP3K10.62560240
62CDK70.61151558
63MARK20.60395337
64MAP2K30.60350504
65PIK3CG0.59590681
66IKBKE0.58261190
67TAF10.58192106
68JAK20.57119723
69BRD40.54340320
70FGFR30.53854364
71AURKA0.53779452
72FYN0.53458745
73AURKB0.50157088
74GRK70.49812137
75TAOK30.48903803
76CAMK40.48781188
77MAPKAPK20.48460244
78ATR0.44855267
79BRSK10.43699937
80MARK30.42269016
81CAMK10.39921378
82DYRK1B0.37954149
83TBK10.34781280
84SIK20.34572530
85CSF1R0.33572860
86TGFBR20.32327400
87PASK0.28374403
88PTK60.27136536
89MAP3K80.26699519
90NTRK20.26218188
91RPS6KB20.25501513
92PDGFRB0.23333399
93MAPK120.22490943
94IRAK40.22121723
95RPS6KC10.20587120
96RPS6KL10.20587120
97PDK10.19998283
98ERBB30.19665340
99FGFR20.19638958
100PRKCH0.18437726

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.80136980
2Primary immunodeficiency_Homo sapiens_hsa053405.34880200
3Alcoholism_Homo sapiens_hsa050344.07596688
4T cell receptor signaling pathway_Homo sapiens_hsa046602.97086337
5Viral carcinogenesis_Homo sapiens_hsa052032.77543616
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.59348988
7Autoimmune thyroid disease_Homo sapiens_hsa053202.43103243
8Hematopoietic cell lineage_Homo sapiens_hsa046402.42493093
9Measles_Homo sapiens_hsa051622.39610402
10Allograft rejection_Homo sapiens_hsa053302.27167669
11Graft-versus-host disease_Homo sapiens_hsa053322.22434683
12Antigen processing and presentation_Homo sapiens_hsa046121.92446550
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.82141446
14Viral myocarditis_Homo sapiens_hsa054161.65116516
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63058835
16Type I diabetes mellitus_Homo sapiens_hsa049401.56461200
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.46410300
18Osteoclast differentiation_Homo sapiens_hsa043801.42068978
19Non-small cell lung cancer_Homo sapiens_hsa052231.39190977
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38016683
21Acute myeloid leukemia_Homo sapiens_hsa052211.36425345
22Proteasome_Homo sapiens_hsa030501.35467325
23Shigellosis_Homo sapiens_hsa051311.32259083
24Prion diseases_Homo sapiens_hsa050201.27858800
25Epstein-Barr virus infection_Homo sapiens_hsa051691.26307989
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25457661
27Pancreatic cancer_Homo sapiens_hsa052121.23977104
28Herpes simplex infection_Homo sapiens_hsa051681.23690778
29B cell receptor signaling pathway_Homo sapiens_hsa046621.22875214
30Hepatitis B_Homo sapiens_hsa051611.20706634
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18656482
32Thyroid cancer_Homo sapiens_hsa052161.17341438
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16107484
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15601346
35Cell cycle_Homo sapiens_hsa041101.10951993
36Chronic myeloid leukemia_Homo sapiens_hsa052201.09838801
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09664280
38Staphylococcus aureus infection_Homo sapiens_hsa051501.05295870
39Colorectal cancer_Homo sapiens_hsa052100.99997332
40Leishmaniasis_Homo sapiens_hsa051400.98121808
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93486280
42Asthma_Homo sapiens_hsa053100.87884177
43Jak-STAT signaling pathway_Homo sapiens_hsa046300.83602021
44Apoptosis_Homo sapiens_hsa042100.82196451
45DNA replication_Homo sapiens_hsa030300.79129267
46HTLV-I infection_Homo sapiens_hsa051660.78952355
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78896872
48Notch signaling pathway_Homo sapiens_hsa043300.77530956
49Legionellosis_Homo sapiens_hsa051340.76488903
50Tuberculosis_Homo sapiens_hsa051520.75672136
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74776359
52Influenza A_Homo sapiens_hsa051640.74519956
53Glioma_Homo sapiens_hsa052140.72889445
54TNF signaling pathway_Homo sapiens_hsa046680.72873074
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70143322
56Endometrial cancer_Homo sapiens_hsa052130.68595312
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68541704
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66035250
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64434499
60Prostate cancer_Homo sapiens_hsa052150.64402448
61Salmonella infection_Homo sapiens_hsa051320.64065038
62mRNA surveillance pathway_Homo sapiens_hsa030150.63972367
63Chemokine signaling pathway_Homo sapiens_hsa040620.62918706
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62284367
65Platelet activation_Homo sapiens_hsa046110.61717264
66Endocytosis_Homo sapiens_hsa041440.60295762
67Non-homologous end-joining_Homo sapiens_hsa034500.59767054
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54167757
69Malaria_Homo sapiens_hsa051440.53295410
70Rheumatoid arthritis_Homo sapiens_hsa053230.52057387
71Inositol phosphate metabolism_Homo sapiens_hsa005620.49190374
72Pertussis_Homo sapiens_hsa051330.47815017
73RNA polymerase_Homo sapiens_hsa030200.46770329
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.43764279
75MicroRNAs in cancer_Homo sapiens_hsa052060.41763068
76Homologous recombination_Homo sapiens_hsa034400.41537799
77Toxoplasmosis_Homo sapiens_hsa051450.39728063
78FoxO signaling pathway_Homo sapiens_hsa040680.39016879
79Spliceosome_Homo sapiens_hsa030400.38152770
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37956223
81p53 signaling pathway_Homo sapiens_hsa041150.36321145
82Fanconi anemia pathway_Homo sapiens_hsa034600.35934601
83Protein export_Homo sapiens_hsa030600.35815789
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35068690
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32582832
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32481678
87RNA transport_Homo sapiens_hsa030130.32419289
88Small cell lung cancer_Homo sapiens_hsa052220.31959506
89Other glycan degradation_Homo sapiens_hsa005110.31671969
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29511373
91VEGF signaling pathway_Homo sapiens_hsa043700.28691450
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.28565312
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27464632
94Hepatitis C_Homo sapiens_hsa051600.27399309
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26040361
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.22272211
97Phagosome_Homo sapiens_hsa041450.20141506
98RNA degradation_Homo sapiens_hsa030180.20019648
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.19976205
100MAPK signaling pathway_Homo sapiens_hsa040100.15590771

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