TRAV11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)9.46700975
2positive regulation of lamellipodium assembly (GO:0010592)8.07457985
3regulation of isotype switching to IgG isotypes (GO:0048302)7.36876638
4regulation of respiratory burst (GO:0060263)6.95516123
5positive regulation of lamellipodium organization (GO:1902745)6.37332026
6positive regulation of macrophage differentiation (GO:0045651)6.26490050
7positive thymic T cell selection (GO:0045059)6.18265117
8DNA deamination (GO:0045006)6.15044750
9cellular response to interleukin-15 (GO:0071350)5.99110790
10lymphocyte costimulation (GO:0031294)5.84127066
11regulation of hydrogen peroxide metabolic process (GO:0010310)5.81539341
12response to xenobiotic stimulus (GO:0009410)5.74901977
13negative thymic T cell selection (GO:0045060)5.71930159
14T cell costimulation (GO:0031295)5.70825711
15negative regulation of necroptotic process (GO:0060546)5.70315825
16T cell migration (GO:0072678)5.61563392
17antigen processing and presentation via MHC class Ib (GO:0002475)5.40746785
18negative T cell selection (GO:0043383)5.38285677
19positive regulation of endothelial cell apoptotic process (GO:2000353)5.23087793
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.14830370
21negative regulation of cell killing (GO:0031342)5.14830370
22T cell receptor signaling pathway (GO:0050852)5.10396209
23negative regulation of B cell mediated immunity (GO:0002713)5.06055488
24negative regulation of immunoglobulin mediated immune response (GO:0002890)5.06055488
25regulation of necroptotic process (GO:0060544)5.04257419
26thymic T cell selection (GO:0045061)4.95785976
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.82290597
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.82290597
29negative regulation of type 2 immune response (GO:0002829)4.70136616
30response to interleukin-15 (GO:0070672)4.64969231
31antigen receptor-mediated signaling pathway (GO:0050851)4.58518618
32negative regulation of necrotic cell death (GO:0060547)4.56313223
33regulation of necrotic cell death (GO:0010939)4.56222490
34Arp2/3 complex-mediated actin nucleation (GO:0034314)4.50978386
35positive T cell selection (GO:0043368)4.50918564
36positive regulation of astrocyte differentiation (GO:0048711)4.48147621
37cellular response to zinc ion (GO:0071294)4.46653969
38regulation of T cell mediated cytotoxicity (GO:0001914)4.45034930
39mucosal-associated lymphoid tissue development (GO:0048537)4.43541080
40Peyers patch development (GO:0048541)4.43541080
41regulation of lamellipodium assembly (GO:0010591)4.42369556
42catecholamine transport (GO:0051937)4.37650402
43norepinephrine metabolic process (GO:0042415)4.37092057
44regulation of B cell receptor signaling pathway (GO:0050855)4.21184595
45regulation of isotype switching (GO:0045191)4.10745610
46defense response to protozoan (GO:0042832)4.10159864
47leukocyte cell-cell adhesion (GO:0007159)4.03300394
48regulation of immunoglobulin secretion (GO:0051023)3.95431287
49antigen processing and presentation of endogenous antigen (GO:0019883)3.91811911
50isotype switching (GO:0045190)3.90560832
51somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.90560832
52somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.90560832
53regulation of immunoglobulin production (GO:0002637)3.83313504
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70583611
55positive regulation of neutrophil chemotaxis (GO:0090023)3.69459959
56positive regulation of neutrophil migration (GO:1902624)3.69459959
57regulation of immunoglobulin mediated immune response (GO:0002889)3.67978498
58T cell selection (GO:0045058)3.67142228
59positive regulation of alpha-beta T cell proliferation (GO:0046641)3.66264630
60positive regulation of gamma-delta T cell activation (GO:0046645)3.62708581
61negative regulation of phagocytosis (GO:0050765)3.59933159
62regulation of leukocyte mediated cytotoxicity (GO:0001910)3.56466159
63regulation of macrophage differentiation (GO:0045649)3.55306281
64regulation of B cell mediated immunity (GO:0002712)3.53924848
65positive regulation of T cell mediated cytotoxicity (GO:0001916)3.47805755
66positive regulation of isotype switching (GO:0045830)3.47012997
67positive regulation of granulocyte chemotaxis (GO:0071624)3.44803940
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.43081336
69response to protozoan (GO:0001562)3.42256129
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.38439358
71regulation of gamma-delta T cell differentiation (GO:0045586)3.35816338
72natural killer cell activation (GO:0030101)3.35054023
73regulation of T cell receptor signaling pathway (GO:0050856)3.34713186
74positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.33660477
75CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.32355320
76T-helper cell differentiation (GO:0042093)3.32355320
77regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.31125847
78regulation of lamellipodium organization (GO:1902743)3.29325976
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.28064338
80chemokine-mediated signaling pathway (GO:0070098)3.27610153
81tolerance induction (GO:0002507)3.27267853
82regulation of B cell differentiation (GO:0045577)3.26023938
83regulation of response to interferon-gamma (GO:0060330)3.22026811
84actin nucleation (GO:0045010)3.21866694
85lymphocyte migration (GO:0072676)3.18699931
86regulation of type I interferon-mediated signaling pathway (GO:0060338)3.16683430
87regulation of cell killing (GO:0031341)3.15585724
88immune response-activating cell surface receptor signaling pathway (GO:0002429)3.15044706
89negative regulation of lymphocyte mediated immunity (GO:0002707)3.13939078
90negative regulation of execution phase of apoptosis (GO:1900118)3.09301949
91B cell proliferation (GO:0042100)3.08350930
92regulation of alpha-beta T cell proliferation (GO:0046640)3.02711178
93actin filament depolymerization (GO:0030042)3.02695856
94positive regulation of cell killing (GO:0031343)3.02133746
95regulation of T cell tolerance induction (GO:0002664)3.00423140
96bone resorption (GO:0045453)2.99375200
97positive regulation of natural killer cell mediated immunity (GO:0002717)2.98067563
98positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.98067563
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G11.8394332
100leukocyte aggregation (GO:0070486)10.1389978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.32146938
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.86679985
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.56865575
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.45035278
5SMAD_19615063_ChIP-ChIP_OVARY_Human4.27399007
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.03015069
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.71219717
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.65288828
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.61311127
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48781617
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.18593107
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03906960
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.97927473
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.97149250
15RUNX_20019798_ChIP-Seq_JUKART_Human2.92819179
16MYB_26560356_Chip-Seq_TH2_Human2.67267796
17MAF_26560356_Chip-Seq_TH1_Human2.66246500
18UTX_26944678_Chip-Seq_JUKART_Human2.59641796
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.50759616
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49661781
21MYB_26560356_Chip-Seq_TH1_Human2.30638649
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.28194422
23SRY_22984422_ChIP-ChIP_TESTIS_Rat2.25485732
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12341874
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.83396108
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82645516
27EGR1_19032775_ChIP-ChIP_M12_Human1.81142414
28SPI1_23547873_ChIP-Seq_NB4_Human1.75037324
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71506681
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69044480
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68229190
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61118945
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60431416
34GATA3_27048872_Chip-Seq_THYMUS_Human1.58972676
35PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.56055156
36MYC_22102868_ChIP-Seq_BL_Human1.47449511
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47241647
38MAF_26560356_Chip-Seq_TH2_Human1.41722844
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41443926
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38046792
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37046554
42CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36425308
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36346237
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35542823
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34183991
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33868043
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31289760
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30998294
49CIITA_25753668_ChIP-Seq_RAJI_Human1.28847874
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.26127034
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25931280
52GATA1_22025678_ChIP-Seq_K562_Human1.25158298
53FOXP3_21729870_ChIP-Seq_TREG_Human1.23040599
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20267967
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20095157
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19758688
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19669884
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19306339
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19044150
60VDR_24763502_ChIP-Seq_THP-1_Human1.17548506
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17183399
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.16071426
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14368881
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13872587
65VDR_23849224_ChIP-Seq_CD4+_Human1.12633826
66LXR_22292898_ChIP-Seq_THP-1_Human1.11661806
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10697921
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.10583574
69SPI1_23127762_ChIP-Seq_K562_Human1.08940728
70EZH2_22144423_ChIP-Seq_EOC_Human1.08627543
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08432303
72FLI1_21867929_ChIP-Seq_CD8_Mouse1.07892855
73SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.06183394
74GATA3_26560356_Chip-Seq_TH2_Human1.03834276
75SPI1_20517297_ChIP-Seq_HL60_Human1.02569082
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01789592
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.01273424
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00463628
79YY1_21170310_ChIP-Seq_MESCs_Mouse0.98204969
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.97553986
81VDR_21846776_ChIP-Seq_THP-1_Human0.97025259
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95570106
83RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95130210
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.94677926
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93880826
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92927738
87MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92718155
88YY1_22570637_ChIP-Seq_MALME-3M_Human0.92632982
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92530388
90BCL6_27268052_Chip-Seq_Bcells_Human0.91542673
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91036239
92CTCF_26484167_Chip-Seq_Bcells_Mouse0.90295698
93IRF8_27001747_Chip-Seq_BMDM_Mouse0.89516412
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89495681
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88651968
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88083448
97MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86526920
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85085139
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84953334
100TET1_21451524_ChIP-Seq_MESCs_Mouse0.84585115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.35813052
2MP0001835_abnormal_antigen_presentation4.42268486
3MP0000685_abnormal_immune_system4.32618785
4MP0003763_abnormal_thymus_physiology4.14404129
5MP0009785_altered_susceptibility_to4.03573054
6MP0006082_CNS_inflammation3.55339260
7MP0003724_increased_susceptibility_to3.49377095
8MP0002909_abnormal_adrenal_gland3.32761874
9MP0003329_amyloid_beta_deposits3.20623651
10MP0005387_immune_system_phenotype3.01223640
11MP0001790_abnormal_immune_system3.01223640
12MP0002166_altered_tumor_susceptibility2.95023510
13MP0005025_abnormal_response_to2.74731904
14MP0004510_myositis2.67086540
15MP0005000_abnormal_immune_tolerance2.59425050
16MP0001853_heart_inflammation2.52296247
17MP0003866_abnormal_defecation2.49520103
18MP0002420_abnormal_adaptive_immunity2.47770376
19MP0001819_abnormal_immune_cell2.42785223
20MP0003252_abnormal_bile_duct2.38604201
21MP0002723_abnormal_immune_serum2.37920425
22MP0002405_respiratory_system_inflammati2.37514500
23MP0001800_abnormal_humoral_immune2.32650386
24MP0002006_tumorigenesis2.30745375
25MP0002933_joint_inflammation2.26329752
26MP0002398_abnormal_bone_marrow2.25596328
27MP0000604_amyloidosis2.16828784
28MP0004947_skin_inflammation2.06927181
29MP0010352_gastrointestinal_tract_polyps2.05754489
30MP0000716_abnormal_immune_system2.03387032
31MP0002452_abnormal_antigen_presenting1.99126380
32MP0005310_abnormal_salivary_gland1.96406152
33MP0005083_abnormal_biliary_tract1.90558175
34MP0002722_abnormal_immune_system1.86699382
35MP0000689_abnormal_spleen_morphology1.75675950
36MP0009333_abnormal_splenocyte_physiolog1.67431636
37MP0002396_abnormal_hematopoietic_system1.65084892
38MP0009764_decreased_sensitivity_to1.58855465
39MP0002419_abnormal_innate_immunity1.57599339
40MP0010155_abnormal_intestine_physiology1.56663062
41MP0003436_decreased_susceptibility_to1.56497105
42MP0002429_abnormal_blood_cell1.55557218
43MP0000703_abnormal_thymus_morphology1.53399392
44MP0002132_abnormal_respiratory_system1.44813108
45MP0008469_abnormal_protein_level1.38811103
46MP0001348_abnormal_lacrimal_gland1.38282330
47MP0002148_abnormal_hypersensitivity_rea1.35058401
48MP0001845_abnormal_inflammatory_respons1.18388374
49MP0009763_increased_sensitivity_to1.14859026
50MP0000015_abnormal_ear_pigmentation1.13812709
51MP0005464_abnormal_platelet_physiology1.12299691
52MP0000639_abnormal_adrenal_gland1.10282394
53MP0008875_abnormal_xenobiotic_pharmacok1.09683747
54MP0001873_stomach_inflammation1.09640515
55MP0000858_altered_metastatic_potential1.07681562
56MP0003045_fibrosis1.05760664
57MP0004381_abnormal_hair_follicle1.04370194
58MP0001851_eye_inflammation1.03036707
59MP0005058_abnormal_lysosome_morphology1.00231718
60MP0005330_cardiomyopathy0.99504184
61MP0009840_abnormal_foam_cell0.94626402
62MP0001533_abnormal_skeleton_physiology0.94085157
63MP0009765_abnormal_xenobiotic_induced0.90642565
64MP0003828_pulmonary_edema0.90302091
65MP0010386_abnormal_urinary_bladder0.89600990
66MP0005166_decreased_susceptibility_to0.89267644
67MP0005023_abnormal_wound_healing0.87577942
68MP0009379_abnormal_foot_pigmentation0.82722122
69MP0004145_abnormal_muscle_electrophysio0.82069486
70MP0002019_abnormal_tumor_incidence0.80818261
71MP0005165_increased_susceptibility_to0.80658996
72MP0000343_altered_response_to0.79671178
73MP0000920_abnormal_myelination0.77419960
74MP0003633_abnormal_nervous_system0.76658737
75MP0001984_abnormal_olfaction0.76289836
76MP0002095_abnormal_skin_pigmentation0.75960474
77MP0002822_catalepsy0.73065590
78MP0003453_abnormal_keratinocyte_physiol0.66872997
79MP0001243_abnormal_dermal_layer0.66151956
80MP0003448_altered_tumor_morphology0.65906873
81MP0002928_abnormal_bile_duct0.63981655
82MP0005451_abnormal_body_composition0.62249959
83MP0000477_abnormal_intestine_morphology0.61385183
84MP0002693_abnormal_pancreas_physiology0.55232987
85MP0008007_abnormal_cellular_replicative0.54156535
86MP0005647_abnormal_sex_gland0.51856275
87MP0010234_abnormal_vibrissa_follicle0.47318018
88MP0003221_abnormal_cardiomyocyte_apopto0.46207142
89MP0005085_abnormal_gallbladder_physiolo0.45538475
90MP0001881_abnormal_mammary_gland0.45505266
91MP0000609_abnormal_liver_physiology0.45158283
92MP0002168_other_aberrant_phenotype0.44790225
93MP0009642_abnormal_blood_homeostasis0.44446954
94MP0008873_increased_physiological_sensi0.43202359
95MP0000627_abnormal_mammary_gland0.42679603
96MP0000249_abnormal_blood_vessel0.40855993
97MP0004147_increased_porphyrin_level0.39719347
98MP0008569_lethality_at_weaning0.38814826
99MP0005584_abnormal_enzyme/coenzyme_acti0.38173174
100MP0003303_peritoneal_inflammation0.36278879

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)9.92503402
2Stomatitis (HP:0010280)8.70909046
3Severe combined immunodeficiency (HP:0004430)8.18062777
4IgG deficiency (HP:0004315)7.17731904
5Combined immunodeficiency (HP:0005387)6.91348896
6Abnormality of T cell physiology (HP:0011840)5.38225790
7Eczematoid dermatitis (HP:0000976)5.27822744
8Elevated erythrocyte sedimentation rate (HP:0003565)5.27403544
9Recurrent bronchitis (HP:0002837)5.22358569
10Abnormality of T cells (HP:0002843)5.19028039
11IgM deficiency (HP:0002850)4.97717949
12IgA deficiency (HP:0002720)4.84621266
13Autoimmune hemolytic anemia (HP:0001890)4.71161555
14Thyroiditis (HP:0100646)4.64402545
15T lymphocytopenia (HP:0005403)4.61036650
16Abnormality of T cell number (HP:0011839)4.48286219
17Chronic diarrhea (HP:0002028)4.28003739
18Gingivitis (HP:0000230)4.26112668
19Hypoplasia of the thymus (HP:0000778)4.18178703
20Hypergammaglobulinemia (HP:0010702)4.10484010
21Amyotrophic lateral sclerosis (HP:0007354)3.78003688
22Chronic mucocutaneous candidiasis (HP:0002728)3.29455516
23Recurrent cutaneous fungal infections (HP:0011370)3.29455516
24Gastrointestinal infarctions (HP:0005244)3.23390407
25Abnormality of eosinophils (HP:0001879)3.22664429
26Aplastic anemia (HP:0001915)3.19917152
273-Methylglutaconic aciduria (HP:0003535)3.14314303
28Oral leukoplakia (HP:0002745)3.13123860
29Nasal polyposis (HP:0100582)3.08575297
30Recurrent fungal infections (HP:0002841)3.03698627
31Chronic otitis media (HP:0000389)3.02538676
32Increased intramyocellular lipid droplets (HP:0012240)3.02291764
33Lymphopenia (HP:0001888)2.99664877
34Bronchitis (HP:0012387)2.94073580
35Hypoproteinemia (HP:0003075)2.91826144
36B lymphocytopenia (HP:0010976)2.91506881
37Abnormality of B cell number (HP:0010975)2.91506881
38Hepatitis (HP:0012115)2.84538470
39Reduced subcutaneous adipose tissue (HP:0003758)2.83589293
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.82986024
41Radial bowing (HP:0002986)2.77139503
42Type 2 muscle fiber atrophy (HP:0003554)2.75615251
43Panhypogammaglobulinemia (HP:0003139)2.74424430
44Increased muscle lipid content (HP:0009058)2.70686657
45Leukocytosis (HP:0001974)2.69538272
46Abnormality of the nasal mucosa (HP:0000433)2.61848517
47Frequent falls (HP:0002359)2.61203063
48Recurrent sinusitis (HP:0011108)2.60502526
49Muscle fiber atrophy (HP:0100295)2.52148517
50Urinary urgency (HP:0000012)2.52083625
51Neuroendocrine neoplasm (HP:0100634)2.47585381
52Albinism (HP:0001022)2.46589117
53Pulmonary fibrosis (HP:0002206)2.37011722
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34227228
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34227228
56Vacuolated lymphocytes (HP:0001922)2.31143600
57Subacute progressive viral hepatitis (HP:0006572)2.27992719
58Recurrent otitis media (HP:0000403)2.27924719
59Recurrent abscess formation (HP:0002722)2.21978749
60Large eyes (HP:0001090)2.12415848
61Vasculitis (HP:0002633)2.12088403
62Lymphoma (HP:0002665)2.10732608
63Myositis (HP:0100614)2.09949685
64Gastrointestinal stroma tumor (HP:0100723)2.09129833
65Recurrent skin infections (HP:0001581)2.07350947
66Micronodular cirrhosis (HP:0001413)2.02589459
67Hepatocellular necrosis (HP:0001404)1.99970353
68Joint swelling (HP:0001386)1.96900267
69Neutropenia (HP:0001875)1.96423126
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94846293
71Hemoptysis (HP:0002105)1.93180498
72Microcytic anemia (HP:0001935)1.88364912
73Increased hepatocellular lipid droplets (HP:0006565)1.85811722
74Atrophy/Degeneration involving motor neurons (HP:0007373)1.85202520
75Agammaglobulinemia (HP:0004432)1.84776720
76Hypoplasia of the ulna (HP:0003022)1.83024370
77Premature graying of hair (HP:0002216)1.81031445
78Diplopia (HP:0000651)1.80495301
79Abnormality of binocular vision (HP:0011514)1.80495301
80Chronic obstructive pulmonary disease (HP:0006510)1.80204021
81Obstructive lung disease (HP:0006536)1.80204021
82Renal cortical cysts (HP:0000803)1.79968594
83Anorexia (HP:0002039)1.77090569
84Hepatic necrosis (HP:0002605)1.76057847
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75372946
86Bowing of the arm (HP:0006488)1.74759743
87Bowed forearm bones (HP:0003956)1.74759743
88Recurrent gram-negative bacterial infections (HP:0005420)1.73556302
89Abnormal platelet function (HP:0011869)1.71061760
90Impaired platelet aggregation (HP:0003540)1.71061760
91Gangrene (HP:0100758)1.70836359
92Hypoalbuminemia (HP:0003073)1.67708049
93Abnormal albumin level (HP:0012116)1.67708049
94Renal Fanconi syndrome (HP:0001994)1.66308231
95Pulmonary infiltrates (HP:0002113)1.65928912
96Lipid accumulation in hepatocytes (HP:0006561)1.63899665
97Progressive microcephaly (HP:0000253)1.62491291
98Emphysema (HP:0002097)1.62447108
99Mediastinal lymphadenopathy (HP:0100721)1.58905040
100Easy fatigability (HP:0003388)1.58769017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK28.00052982
2MAP3K125.37358043
3KDR5.30742620
4TESK14.79531471
5TXK3.81805383
6LIMK13.42279801
7ZAP703.41748603
8MAP4K13.26829264
9BUB13.18693447
10EIF2AK12.61122167
11BLK2.35705090
12PIM21.73531962
13IKBKE1.73412501
14MYLK1.52335930
15JAK11.39586046
16TBK11.38356239
17EIF2AK31.33784826
18ITK1.27902769
19LCK1.25614065
20IRAK41.20304861
21DAPK31.12027728
22TLK11.05025855
23ERN11.03142938
24ARAF1.02147234
25SIK10.98483882
26MAP3K110.97586553
27LYN0.96042019
28RAF10.95930845
29FGFR10.92855440
30PRKCQ0.92637552
31FGFR40.92477600
32SYK0.92345991
33TEC0.91252045
34SIK30.89615126
35BTK0.82734565
36DAPK10.82122877
37JAK30.81313118
38IRAK20.74934585
39TNK20.70321490
40CLK10.68923681
41MUSK0.67088062
42HCK0.66671002
43STK160.65874247
44ROCK10.64693287
45NTRK30.64501211
46GRK60.59325435
47FYN0.58987136
48CDK30.58138628
49CDK190.56371777
50SIK20.52523762
51EIF2AK20.52498222
52MAP2K70.47875500
53INSR0.45651161
54TYK20.44555834
55NLK0.42954871
56SRC0.36194227
57CSK0.35996416
58MAP2K60.34479525
59ABL10.34146508
60NME10.33712679
61PRKCD0.30469633
62LRRK20.29583154
63ILK0.29488246
64PRKG20.28472930
65SCYL20.27342893
66CSNK1G30.26140092
67PAK40.24340104
68IGF1R0.24282613
69CSNK1A1L0.21108064
70JAK20.20731411
71ERBB40.20650633
72STK100.20359224
73KIT0.19752028
74PDK30.18005474
75PDK40.18005474
76TAOK20.17702548
77IRAK10.17412255
78BCKDK0.17237903
79CSNK1G20.17167789
80NME20.17022517
81PRKCA0.15362945
82CSF1R0.14702629
83MAP3K10.14681179
84AURKB0.13492302
85TNIK0.12840857
86CSNK1A10.12816571
87MAP3K50.11823227
88PRKCH0.11168883
89IKBKB0.09878682
90CDK11A0.09219499
91MAP2K40.09051819
92PRKCI0.08694615
93RPS6KA40.06412370
94CAMK10.05118621
95VRK10.04651984
96AURKA0.04639678
97ROCK20.04603773
98CDK150.04418787
99PRKD10.04197244
100CDK140.04002134

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.31226783
2Allograft rejection_Homo sapiens_hsa053304.85039075
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.32110235
4Asthma_Homo sapiens_hsa053104.16869143
5Viral myocarditis_Homo sapiens_hsa054163.69683961
6Autoimmune thyroid disease_Homo sapiens_hsa053203.60414105
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.45598551
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.11490288
9T cell receptor signaling pathway_Homo sapiens_hsa046603.01652808
10Antigen processing and presentation_Homo sapiens_hsa046122.46729986
11Graft-versus-host disease_Homo sapiens_hsa053322.30493817
12Proteasome_Homo sapiens_hsa030502.25784817
13Hematopoietic cell lineage_Homo sapiens_hsa046402.02237133
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99797753
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.74436919
16Measles_Homo sapiens_hsa051621.71991714
17Malaria_Homo sapiens_hsa051441.71176068
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36435555
19Pentose phosphate pathway_Homo sapiens_hsa000301.25449863
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22012069
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10276194
22Leishmaniasis_Homo sapiens_hsa051401.04195160
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04181753
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03634100
25VEGF signaling pathway_Homo sapiens_hsa043701.02985630
26Spliceosome_Homo sapiens_hsa030400.92354971
27B cell receptor signaling pathway_Homo sapiens_hsa046620.89167592
28Ribosome_Homo sapiens_hsa030100.88218647
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88172759
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80393121
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79063104
32Herpes simplex infection_Homo sapiens_hsa051680.75684064
33Protein export_Homo sapiens_hsa030600.73159987
34DNA replication_Homo sapiens_hsa030300.72181486
35Toxoplasmosis_Homo sapiens_hsa051450.71684794
36Chemokine signaling pathway_Homo sapiens_hsa040620.71647503
37Jak-STAT signaling pathway_Homo sapiens_hsa046300.69180076
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.68537091
39Fatty acid elongation_Homo sapiens_hsa000620.63602368
40Nucleotide excision repair_Homo sapiens_hsa034200.59720859
41Other glycan degradation_Homo sapiens_hsa005110.57907508
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55532427
43Regulation of autophagy_Homo sapiens_hsa041400.55313821
44Apoptosis_Homo sapiens_hsa042100.55242437
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53761017
46Shigellosis_Homo sapiens_hsa051310.52743523
47Mismatch repair_Homo sapiens_hsa034300.52577467
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.52531191
49Biosynthesis of amino acids_Homo sapiens_hsa012300.51341726
50Ether lipid metabolism_Homo sapiens_hsa005650.50689886
51Salmonella infection_Homo sapiens_hsa051320.50594348
52Osteoclast differentiation_Homo sapiens_hsa043800.49793622
53Colorectal cancer_Homo sapiens_hsa052100.49243427
54HTLV-I infection_Homo sapiens_hsa051660.49183000
55Homologous recombination_Homo sapiens_hsa034400.48879881
56Legionellosis_Homo sapiens_hsa051340.47276776
57p53 signaling pathway_Homo sapiens_hsa041150.46498255
58Pancreatic cancer_Homo sapiens_hsa052120.45671105
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45128520
60Pyruvate metabolism_Homo sapiens_hsa006200.43886713
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.43864069
62Base excision repair_Homo sapiens_hsa034100.43012998
63Sulfur relay system_Homo sapiens_hsa041220.41177496
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40614481
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39334945
66Staphylococcus aureus infection_Homo sapiens_hsa051500.38164819
67Carbon metabolism_Homo sapiens_hsa012000.36685904
68Systemic lupus erythematosus_Homo sapiens_hsa053220.36370728
69Fatty acid biosynthesis_Homo sapiens_hsa000610.35468894
70Parkinsons disease_Homo sapiens_hsa050120.30554176
71Alzheimers disease_Homo sapiens_hsa050100.30233059
72Pyrimidine metabolism_Homo sapiens_hsa002400.28042642
73RNA degradation_Homo sapiens_hsa030180.26684105
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26308448
75Oxidative phosphorylation_Homo sapiens_hsa001900.26303168
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23179946
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23020415
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22254921
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20065885
80Lysosome_Homo sapiens_hsa041420.19217421
81RNA polymerase_Homo sapiens_hsa030200.18314088
82Hepatitis B_Homo sapiens_hsa051610.17164850
83Acute myeloid leukemia_Homo sapiens_hsa052210.15607544
84Adherens junction_Homo sapiens_hsa045200.14628972
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14430649
86Tuberculosis_Homo sapiens_hsa051520.14287833
87Fatty acid metabolism_Homo sapiens_hsa012120.14268274
88Fatty acid degradation_Homo sapiens_hsa000710.14240590
89Endocytosis_Homo sapiens_hsa041440.14026814
90Pertussis_Homo sapiens_hsa051330.12924156
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12307689
92ABC transporters_Homo sapiens_hsa020100.11539603
93Type I diabetes mellitus_Homo sapiens_hsa049400.11394690
94Rap1 signaling pathway_Homo sapiens_hsa040150.11069871
95Purine metabolism_Homo sapiens_hsa002300.10732099
96Viral carcinogenesis_Homo sapiens_hsa052030.10004456
97Basal transcription factors_Homo sapiens_hsa030220.08584644
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07921039
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.07542291
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.07290802

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