TRAV12-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.48463210
2negative thymic T cell selection (GO:0045060)8.20336389
3positive thymic T cell selection (GO:0045059)7.94656837
4positive regulation of gamma-delta T cell activation (GO:0046645)7.52219501
5positive T cell selection (GO:0043368)7.46858983
6thymic T cell selection (GO:0045061)7.31375763
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.26266389
8negative regulation of cell killing (GO:0031342)7.26266389
9regulation of gamma-delta T cell differentiation (GO:0045586)7.04343341
10T cell selection (GO:0045058)6.82320970
11regulation of isotype switching to IgG isotypes (GO:0048302)6.72473110
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.69321570
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.40388556
14regulation of gamma-delta T cell activation (GO:0046643)6.26040040
15response to interleukin-15 (GO:0070672)6.20658363
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.15448578
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.15448578
18cellular response to interleukin-15 (GO:0071350)6.08895655
19T cell receptor signaling pathway (GO:0050852)5.97001720
20leukocyte aggregation (GO:0070486)5.72184305
21T cell costimulation (GO:0031295)5.57824348
22interferon-gamma production (GO:0032609)5.52904658
23lymphocyte costimulation (GO:0031294)5.52184254
24regulation of T cell tolerance induction (GO:0002664)5.48624257
25antigen processing and presentation of endogenous antigen (GO:0019883)5.13995898
26antigen receptor-mediated signaling pathway (GO:0050851)4.99511222
27regulation of interleukin-2 biosynthetic process (GO:0045076)4.97713507
28positive regulation of B cell differentiation (GO:0045579)4.94759242
29T cell migration (GO:0072678)4.85434001
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82343132
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.70576242
32regulation of alpha-beta T cell proliferation (GO:0046640)4.61824551
33regulation of regulatory T cell differentiation (GO:0045589)4.59576149
34positive regulation of tolerance induction (GO:0002645)4.57259489
35sequestering of actin monomers (GO:0042989)4.53334743
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.50359250
37positive regulation of alpha-beta T cell proliferation (GO:0046641)4.43784887
38regulation of T cell receptor signaling pathway (GO:0050856)4.38472260
39activated T cell proliferation (GO:0050798)4.32058593
40regulation of B cell differentiation (GO:0045577)4.25926333
41positive regulation of interleukin-2 production (GO:0032743)4.25808182
42regulation of isotype switching (GO:0045191)4.15509651
43tolerance induction (GO:0002507)4.06549336
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.04379407
45positive regulation of granulocyte differentiation (GO:0030854)4.04143392
46negative regulation of T cell mediated immunity (GO:0002710)4.02190529
47regulation of interleukin-12 biosynthetic process (GO:0045075)4.00441908
48T cell differentiation (GO:0030217)3.97709642
49regulation of tolerance induction (GO:0002643)3.94281446
50NIK/NF-kappaB signaling (GO:0038061)3.84735479
51regulation of immunoglobulin mediated immune response (GO:0002889)3.81796000
52mast cell activation (GO:0045576)3.81627088
53positive regulation of humoral immune response (GO:0002922)3.79533380
54alpha-beta T cell differentiation (GO:0046632)3.78923419
55positive regulation of isotype switching (GO:0045830)3.72815785
56regulation of response to interferon-gamma (GO:0060330)3.72099263
57natural killer cell differentiation (GO:0001779)3.70963649
58regulation of type I interferon-mediated signaling pathway (GO:0060338)3.70737730
59regulation of B cell mediated immunity (GO:0002712)3.67772585
60regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.66747223
61negative regulation of lymphocyte mediated immunity (GO:0002707)3.66599013
62T cell activation (GO:0042110)3.65338901
63alpha-beta T cell activation (GO:0046631)3.65276391
64regulation of immunoglobulin production (GO:0002637)3.59777286
65positive regulation of B cell mediated immunity (GO:0002714)3.56948362
66positive regulation of immunoglobulin mediated immune response (GO:0002891)3.56948362
67positive regulation of T cell mediated cytotoxicity (GO:0001916)3.56814536
68regulation of interleukin-4 production (GO:0032673)3.55163731
69regulation of B cell receptor signaling pathway (GO:0050855)3.53870454
70negative regulation of leukocyte mediated immunity (GO:0002704)3.52648369
71regulation of T cell mediated cytotoxicity (GO:0001914)3.52161401
72immune response-activating cell surface receptor signaling pathway (GO:0002429)3.49172786
73regulation of defense response to virus by virus (GO:0050690)3.48817072
74regulation of leukocyte mediated cytotoxicity (GO:0001910)3.46611001
75antigen processing and presentation via MHC class Ib (GO:0002475)3.44853106
76positive regulation of natural killer cell mediated immunity (GO:0002717)3.40155042
77positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.40155042
78positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.39154875
79negative regulation of T cell apoptotic process (GO:0070233)3.38371881
80CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.36777209
81immunoglobulin mediated immune response (GO:0016064)3.35324478
82T cell homeostasis (GO:0043029)3.33987131
83response to type I interferon (GO:0034340)3.33212434
84negative regulation of interleukin-12 production (GO:0032695)3.32416218
85positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.31044385
86positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.30700131
87V(D)J recombination (GO:0033151)3.29613043
88positive regulation of interleukin-4 production (GO:0032753)3.29539593
89regulation of natural killer cell mediated immunity (GO:0002715)3.28852526
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.28852526
91regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.28053719
92leukocyte cell-cell adhesion (GO:0007159)3.27838849
93B cell receptor signaling pathway (GO:0050853)3.26409972
94positive regulation of DNA recombination (GO:0045911)3.26288074
95type I interferon signaling pathway (GO:0060337)3.25037372
96cellular response to type I interferon (GO:0071357)3.25037372
97natural killer cell activation (GO:0030101)3.24070429
98positive regulation of T cell activation (GO:0050870)3.22567222
99regulation of alpha-beta T cell activation (GO:0046634)3.20272372
100positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.19965916
101CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.18386581
102positive regulation of immunoglobulin production (GO:0002639)3.18178761
103DNA deamination (GO:0045006)3.15895249
104cellular response to interferon-beta (GO:0035458)3.15698204
105lymphocyte homeostasis (GO:0002260)3.15016147
106regulation of cell killing (GO:0031341)3.13253566
107regulation of interleukin-2 production (GO:0032663)3.13013304
108negative regulation of B cell mediated immunity (GO:0002713)3.12491892
109negative regulation of immunoglobulin mediated immune response (GO:0002890)3.12491892
110heterotypic cell-cell adhesion (GO:0034113)3.11111000
111negative regulation of T cell receptor signaling pathway (GO:0050860)3.11005311
112negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.10479728
113positive regulation of alpha-beta T cell activation (GO:0046635)3.10065060
114positive regulation of cell killing (GO:0031343)3.09850537
115negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.09046258
116positive regulation of macrophage differentiation (GO:0045651)3.08301018
117positive regulation of calcium-mediated signaling (GO:0050850)3.06545482
118mast cell activation involved in immune response (GO:0002279)3.06216077
119mast cell degranulation (GO:0043303)3.06216077
120positive regulation of interleukin-8 secretion (GO:2000484)3.04974250
121regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04316031
122detection of bacterium (GO:0016045)3.02627407
123cellular response to interleukin-4 (GO:0071353)3.02063592
124myeloid dendritic cell differentiation (GO:0043011)3.01832530
125negative regulation of adaptive immune response (GO:0002820)3.01535587
126positive regulation of T cell differentiation in thymus (GO:0033089)3.01014617
127CD4-positive, alpha-beta T cell activation (GO:0035710)3.00214242
128T-helper cell differentiation (GO:0042093)3.00143277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.11682730
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.91362398
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.05918945
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.98853931
5RUNX_20019798_ChIP-Seq_JUKART_Human3.78544585
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.66392793
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.59730223
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59398729
9MYC_22102868_ChIP-Seq_BL_Human3.57056251
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.48582116
11MYB_26560356_Chip-Seq_TH2_Human3.43497785
12MAF_26560356_Chip-Seq_TH1_Human3.10913898
13UTX_26944678_Chip-Seq_JUKART_Human2.78938564
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77330918
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74855793
16MYB_26560356_Chip-Seq_TH1_Human2.74088117
17E2F7_22180533_ChIP-Seq_HELA_Human2.72813062
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.67439959
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.41393283
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38486756
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19843528
22MAF_26560356_Chip-Seq_TH2_Human2.18333147
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17505560
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.14163513
25VDR_21846776_ChIP-Seq_THP-1_Human2.12072048
26GATA3_27048872_Chip-Seq_THYMUS_Human2.09288266
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02992731
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.99448183
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96932390
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96239221
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91647411
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79273733
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78808632
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76770819
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.75467993
36SPI1_23547873_ChIP-Seq_NB4_Human1.70407031
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67495347
38TCF7_22412390_ChIP-Seq_EML_Mouse1.64814414
39CIITA_25753668_ChIP-Seq_RAJI_Human1.61509649
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56070232
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55768944
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53496177
43KDM2B_26808549_Chip-Seq_DND41_Human1.52734991
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52601182
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52559176
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51814321
47VDR_23849224_ChIP-Seq_CD4+_Human1.49477596
48VDR_24763502_ChIP-Seq_THP-1_Human1.46270740
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46117072
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.43438191
51RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42962183
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40230513
53FOXP3_21729870_ChIP-Seq_TREG_Human1.32907185
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28817045
55SCL_19346495_ChIP-Seq_HPC-7_Human1.27705366
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26375218
57SPI1_23127762_ChIP-Seq_K562_Human1.25460324
58GATA3_26560356_Chip-Seq_TH2_Human1.23401587
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20873835
60GATA1_22025678_ChIP-Seq_K562_Human1.18934890
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17578312
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16940435
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15082625
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14678374
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14530673
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.13311241
67PU_27001747_Chip-Seq_BMDM_Mouse1.09431966
68VDR_24787735_ChIP-Seq_THP-1_Human1.06482957
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.06272594
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.02835797
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02475232
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02069902
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01542674
74ETS1_20019798_ChIP-Seq_JURKAT_Human0.98199848
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98089178
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97852979
77ELK3_25401928_ChIP-Seq_HUVEC_Human0.97378838
78MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97100795
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95042737
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94787415
81BCL6_27268052_Chip-Seq_Bcells_Human0.92489086
82GATA3_26560356_Chip-Seq_TH1_Human0.91047351
83EST1_17652178_ChIP-ChIP_JURKAT_Human0.90923321
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90367668
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89953162
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89614078
87ELK1_19687146_ChIP-ChIP_HELA_Human0.89445664
88E2F4_17652178_ChIP-ChIP_JURKAT_Human0.88882245
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87285381
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86573086
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86316934
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.86190754
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85879281
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85622166
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84253502
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83395334
97KDM5A_27292631_Chip-Seq_BREAST_Human0.83141893
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81831390
99XRN2_22483619_ChIP-Seq_HELA_Human0.80781636
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79853850
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79494222
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79186272
103SMRT_27268052_Chip-Seq_Bcells_Human0.78650203
104FLI1_27457419_Chip-Seq_LIVER_Mouse0.77735154
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.77227998
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75763108
107GATA1_19941826_ChIP-Seq_K562_Human0.75467362
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75365825
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75359631
110P300_27268052_Chip-Seq_Bcells_Human0.75237707
111SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.74936605
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74896850
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74730408
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73920599
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73315549
116LXR_22292898_ChIP-Seq_THP-1_Human0.72315493
117RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72282049
118BCOR_27268052_Chip-Seq_Bcells_Human0.70878891
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70308809
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70297050
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70047488
122EGR1_19032775_ChIP-ChIP_M12_Human0.69710822
123MYC_18358816_ChIP-ChIP_MESCs_Mouse0.69689183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.19872888
2MP0005671_abnormal_response_to4.98999270
3MP0002166_altered_tumor_susceptibility4.24906909
4MP0001835_abnormal_antigen_presentation3.54349175
5MP0000685_abnormal_immune_system3.54285286
6MP0002006_tumorigenesis3.35286099
7MP0001800_abnormal_humoral_immune3.18897801
8MP0001790_abnormal_immune_system3.08687119
9MP0005387_immune_system_phenotype3.08687119
10MP0005000_abnormal_immune_tolerance2.93822903
11MP0002398_abnormal_bone_marrow2.87534924
12MP0000703_abnormal_thymus_morphology2.87450403
13MP0009333_abnormal_splenocyte_physiolog2.87076450
14MP0002723_abnormal_immune_serum2.85955888
15MP0002420_abnormal_adaptive_immunity2.85148785
16MP0001819_abnormal_immune_cell2.80860624
17MP0009785_altered_susceptibility_to2.80233761
18MP0003724_increased_susceptibility_to2.70567881
19MP0003866_abnormal_defecation2.63252102
20MP0002405_respiratory_system_inflammati2.60817246
21MP0002452_abnormal_antigen_presenting2.52253795
22MP0005025_abnormal_response_to2.52047658
23MP0000716_abnormal_immune_system2.51549929
24MP0002722_abnormal_immune_system2.46791564
25MP0001873_stomach_inflammation2.43922473
26MP0003436_decreased_susceptibility_to2.40084272
27MP0002277_abnormal_respiratory_mucosa2.38085779
28MP0003300_gastrointestinal_ulcer2.36595067
29MP0002933_joint_inflammation2.34772888
30MP0000689_abnormal_spleen_morphology2.32888206
31MP0010155_abnormal_intestine_physiology2.29730174
32MP0006082_CNS_inflammation2.27655731
33MP0004947_skin_inflammation2.17877603
34MP0002429_abnormal_blood_cell2.01953588
35MP0004510_myositis1.97072902
36MP0004381_abnormal_hair_follicle1.93213294
37MP0002396_abnormal_hematopoietic_system1.83465887
38MP0002148_abnormal_hypersensitivity_rea1.76735153
39MP0003303_peritoneal_inflammation1.71896783
40MP0002419_abnormal_innate_immunity1.68174547
41MP0001845_abnormal_inflammatory_respons1.62712693
42MP0001853_heart_inflammation1.49286084
43MP0002009_preneoplasia1.42764515
44MP0005464_abnormal_platelet_physiology1.40962504
45MP0005310_abnormal_salivary_gland1.36582963
46MP0000858_altered_metastatic_potential1.22871567
47MP0005075_abnormal_melanosome_morpholog1.20937978
48MP0008469_abnormal_protein_level1.20838557
49MP0004808_abnormal_hematopoietic_stem1.20356845
50MP0002132_abnormal_respiratory_system1.15215588
51MP0001533_abnormal_skeleton_physiology1.08522258
52MP0003191_abnormal_cellular_cholesterol1.08475397
53MP0000490_abnormal_crypts_of1.04398242
54MP0002019_abnormal_tumor_incidence0.98579675
55MP0005379_endocrine/exocrine_gland_phen0.94163270
56MP0004883_abnormal_blood_vessel0.93479664
57MP0001851_eye_inflammation0.92798237
58MP0003448_altered_tumor_morphology0.92055973
59MP0008260_abnormal_autophagy0.90090802
60MP0002138_abnormal_hepatobiliary_system0.88647469
61MP0000465_gastrointestinal_hemorrhage0.85512904
62MP0005023_abnormal_wound_healing0.84245094
63MP0003828_pulmonary_edema0.81908656
64MP0001348_abnormal_lacrimal_gland0.81812946
65MP0010352_gastrointestinal_tract_polyps0.81513178
66MP0004185_abnormal_adipocyte_glucose0.81278150
67MP0002998_abnormal_bone_remodeling0.79995143
68MP0010234_abnormal_vibrissa_follicle0.78305413
69MP0008961_abnormal_basal_metabolism0.76692473
70MP0003172_abnormal_lysosome_physiology0.73346025
71MP0005397_hematopoietic_system_phenotyp0.71115901
72MP0001545_abnormal_hematopoietic_system0.71115901
73MP0003221_abnormal_cardiomyocyte_apopto0.69637756
74MP0000477_abnormal_intestine_morphology0.69083319
75MP0000249_abnormal_blood_vessel0.66967944
76MP0001243_abnormal_dermal_layer0.65719969
77MP0009765_abnormal_xenobiotic_induced0.65408776
78MP0008569_lethality_at_weaning0.63828730
79MP0009763_increased_sensitivity_to0.63644869
80MP0002693_abnormal_pancreas_physiology0.60674379
81MP0003795_abnormal_bone_structure0.60169198
82MP0008057_abnormal_DNA_replication0.58748480
83MP0009278_abnormal_bone_marrow0.58296442
84MP0000609_abnormal_liver_physiology0.57120781
85MP0003453_abnormal_keratinocyte_physiol0.55895738
86MP0005164_abnormal_response_to0.55122653
87MP0009764_decreased_sensitivity_to0.54149873
88MP0005166_decreased_susceptibility_to0.53966269
89MP0004957_abnormal_blastocyst_morpholog0.52223289
90MP0008058_abnormal_DNA_repair0.52083908
91MP0008874_decreased_physiological_sensi0.51891695
92MP0005381_digestive/alimentary_phenotyp0.50746258
93MP0000604_amyloidosis0.50695074
94MP0001663_abnormal_digestive_system0.49826295
95MP0004130_abnormal_muscle_cell0.48935591
96MP0005451_abnormal_body_composition0.47706873
97MP0001986_abnormal_taste_sensitivity0.44892144
98MP0001191_abnormal_skin_condition0.44844721
99MP0003693_abnormal_embryo_hatching0.44436245
100MP0002822_catalepsy0.44393741
101MP0008995_early_reproductive_senescence0.42832928
102MP0003077_abnormal_cell_cycle0.40793923
103MP0005535_abnormal_body_temperature0.40627889
104MP0002083_premature_death0.40378716
105MP0003252_abnormal_bile_duct0.39839730
106MP0005174_abnormal_tail_pigmentation0.39814161
107MP0010094_abnormal_chromosome_stability0.39568589
108MP0000313_abnormal_cell_death0.39049669
109MP0008873_increased_physiological_sensi0.38593994
110MP0002136_abnormal_kidney_physiology0.38340609
111MP0005584_abnormal_enzyme/coenzyme_acti0.37991898
112MP0001919_abnormal_reproductive_system0.37041800
113MP0003045_fibrosis0.35167308
114MP0000598_abnormal_liver_morphology0.34979638
115MP0001216_abnormal_epidermal_layer0.34947201
116MP0005390_skeleton_phenotype0.34880011
117MP0000367_abnormal_coat/_hair0.34489740
118MP0009642_abnormal_blood_homeostasis0.33710997
119MP0000015_abnormal_ear_pigmentation0.32204656
120MP0002163_abnormal_gland_morphology0.31963804
121MP0001881_abnormal_mammary_gland0.31728814
122MP0003943_abnormal_hepatobiliary_system0.31563371
123MP0009840_abnormal_foam_cell0.30771307
124MP0004742_abnormal_vestibular_system0.29672970
125MP0001661_extended_life_span0.28078633

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.50194812
2Abnormality of T cell number (HP:0011839)8.23026677
3Elevated erythrocyte sedimentation rate (HP:0003565)7.34593352
4Severe combined immunodeficiency (HP:0004430)7.29016283
5Combined immunodeficiency (HP:0005387)6.58837481
6Abnormality of T cells (HP:0002843)5.90569900
7Abnormality of B cell number (HP:0010975)5.51917111
8B lymphocytopenia (HP:0010976)5.51917111
9Recurrent bronchitis (HP:0002837)5.50431395
10Stomatitis (HP:0010280)5.12991848
11IgG deficiency (HP:0004315)4.86369442
12Recurrent fungal infections (HP:0002841)4.54254554
13IgM deficiency (HP:0002850)4.52495254
14Panhypogammaglobulinemia (HP:0003139)4.51903041
15Thyroiditis (HP:0100646)4.48244997
16Autoimmune hemolytic anemia (HP:0001890)4.45602971
17Abnormality of eosinophils (HP:0001879)4.37944038
18Abnormality of macrophages (HP:0004311)4.32491676
19Chronic otitis media (HP:0000389)4.31915316
20Recurrent viral infections (HP:0004429)4.21682107
21Aplastic anemia (HP:0001915)4.17767064
22Chronic mucocutaneous candidiasis (HP:0002728)4.14524420
23Recurrent cutaneous fungal infections (HP:0011370)4.14524420
24Recurrent bacterial skin infections (HP:0005406)4.10703368
25Pustule (HP:0200039)4.01917848
26Eczematoid dermatitis (HP:0000976)4.00082140
27Myositis (HP:0100614)3.95921003
28Chronic diarrhea (HP:0002028)3.88425430
29Increased IgM level (HP:0003496)3.85664538
30Lymphopenia (HP:0001888)3.79183417
31Abnormality of T cell physiology (HP:0011840)3.78616273
32Leukocytosis (HP:0001974)3.74167428
33Abnormality of the fingertips (HP:0001211)3.71008758
34Nasal polyposis (HP:0100582)3.69761568
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.67549611
36Hypoplasia of the thymus (HP:0000778)3.67448388
37Basal cell carcinoma (HP:0002671)3.58843905
38Eosinophilia (HP:0001880)3.49761654
39Bronchitis (HP:0012387)3.24831557
40Joint swelling (HP:0001386)3.19989768
41Abnormality of the nasal mucosa (HP:0000433)3.06782331
42Fatigue (HP:0012378)3.05238824
43Granulocytopenia (HP:0001913)3.03916618
44Abnormal delayed hypersensitivity skin test (HP:0002963)3.03070035
45Lymphoma (HP:0002665)2.93805698
46Hypergammaglobulinemia (HP:0010702)2.92041950
47Optic neuritis (HP:0100653)2.91430102
48Retrobulbar optic neuritis (HP:0100654)2.91430102
49Hypochromic microcytic anemia (HP:0004840)2.90007313
50Recurrent sinusitis (HP:0011108)2.87695169
51IgA deficiency (HP:0002720)2.83274830
52Orchitis (HP:0100796)2.79116465
53Hypochromic anemia (HP:0001931)2.78613804
54Recurrent otitis media (HP:0000403)2.73221919
55Gangrene (HP:0100758)2.73219798
56Hemoptysis (HP:0002105)2.71401727
57Agammaglobulinemia (HP:0004432)2.68912325
58Meningitis (HP:0001287)2.68022025
59Recurrent gram-negative bacterial infections (HP:0005420)2.61668757
60Vasculitis (HP:0002633)2.57785894
61Pulmonary infiltrates (HP:0002113)2.54391793
62Slow saccadic eye movements (HP:0000514)2.44812652
63Papilloma (HP:0012740)2.42905996
64Verrucae (HP:0200043)2.42905996
65Autoimmune thrombocytopenia (HP:0001973)2.38221672
66Reduced subcutaneous adipose tissue (HP:0003758)2.37691470
67Chronic sinusitis (HP:0011109)2.34326767
68Glomerulopathy (HP:0100820)2.34226957
693-Methylglutaconic aciduria (HP:0003535)2.33605345
70Prolonged bleeding time (HP:0003010)2.32652964
71Inflammation of the large intestine (HP:0002037)2.32586039
72Entropion (HP:0000621)2.31341813
73Poikiloderma (HP:0001029)2.29779236
74Anorexia (HP:0002039)2.28882419
75Abnormality of the pleura (HP:0002103)2.28776852
76Polyneuropathy (HP:0001271)2.27880203
77Urticaria (HP:0001025)2.27492954
78Thrombocytosis (HP:0001894)2.27225070
79Hypoproteinemia (HP:0003075)2.25577249
80Seborrheic dermatitis (HP:0001051)2.24967096
81Abnormality of the prostate (HP:0008775)2.21501453
82Gastrointestinal inflammation (HP:0004386)2.18857640
83Recurrent abscess formation (HP:0002722)2.18066336
84Cheilitis (HP:0100825)2.17362481
85Microcytic anemia (HP:0001935)2.15312549
86Spontaneous hematomas (HP:0007420)2.14476214
87Recurrent skin infections (HP:0001581)2.13202840
88Episodic fever (HP:0001954)2.12918472
89Alveolar cell carcinoma (HP:0006519)2.10904518
90Keratoconjunctivitis sicca (HP:0001097)2.09066888
91Encephalitis (HP:0002383)2.05035693
92Mediastinal lymphadenopathy (HP:0100721)2.04895943
93Gastrointestinal infarctions (HP:0005244)2.03622379
94Papilledema (HP:0001085)2.03052435
95Chronic obstructive pulmonary disease (HP:0006510)2.01997053
96Obstructive lung disease (HP:0006536)2.01997053
97Aplasia/Hypoplasia of the thymus (HP:0010515)1.98703457
98Bronchiectasis (HP:0002110)1.96089207
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95241341
100Neoplasm of the tracheobronchial system (HP:0100552)1.94984135
101Ileus (HP:0002595)1.94622302
102Gingival bleeding (HP:0000225)1.93640157
103Increased IgE level (HP:0003212)1.93349661
104Osteomyelitis (HP:0002754)1.89505450
105Gastrointestinal stroma tumor (HP:0100723)1.87234643
106Keratoconjunctivitis (HP:0001096)1.86566966
107Pulmonary embolism (HP:0002204)1.85143578
108Amyotrophic lateral sclerosis (HP:0007354)1.83762876
109Emphysema (HP:0002097)1.82717204
110Epistaxis (HP:0000421)1.80915921
111Ureteral stenosis (HP:0000071)1.80788535
112Prominent nose (HP:0000448)1.80595417
113Skin rash (HP:0000988)1.77529790
114Large eyes (HP:0001090)1.76145735
115Colitis (HP:0002583)1.73874701
116Arterial thrombosis (HP:0004420)1.72381038
117Petechiae (HP:0000967)1.70829110
118Arthralgia (HP:0002829)1.69347336
119Chest pain (HP:0100749)1.68790778
120Teleangiectasia of the skin (HP:0100585)1.64454396
121Skin ulcer (HP:0200042)1.63472087
122Abnormal platelet volume (HP:0011876)1.63178455
123Abnormality of the endocardium (HP:0004306)1.61753290
124Gingivitis (HP:0000230)1.60461382
125Hepatitis (HP:0012115)1.60235479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.37388272
2MAP4K15.99833563
3IKBKE3.71373054
4ZAP703.54322792
5ITK3.25605874
6FGFR43.20225742
7JAK32.88422848
8NLK2.84088749
9AKT32.69417563
10TYK22.54515916
11RIPK42.46740984
12TESK22.42616987
13TBK12.41517280
14KDR2.29481821
15SIK32.24999147
16JAK12.16306451
17MAP3K142.14629741
18LCK1.92377924
19TEC1.84033466
20STK101.81415529
21FGFR31.78993603
22GRK61.73147734
23NME21.72766344
24TAOK31.54872051
25SYK1.43699469
26HCK1.33898760
27MST41.33065314
28CSK1.32760169
29MAP3K111.29914849
30MAP3K131.29912256
31IRAK41.25230577
32CAMKK21.24675878
33TAOK11.19879319
34PRKCH1.19447624
35TNK21.18302512
36IKBKB1.17637886
37EIF2AK11.13239659
38PRKCQ1.11048308
39BTK1.10531722
40KIT1.04180582
41SGK20.95891142
42TAOK20.93584425
43CHUK0.90743564
44CAMKK10.88230713
45PRPF4B0.86213169
46RPS6KA40.85228379
47EEF2K0.83563435
48JAK20.83153133
49DYRK30.82778834
50TESK10.82625975
51FGR0.79946981
52MAP3K100.79320370
53PKN20.78817561
54PDGFRB0.74933996
55BLK0.74293606
56LYN0.73547769
57PASK0.72469871
58IRAK10.72457969
59IRAK20.71328303
60GRK70.70115396
61PIM10.69269571
62MAP3K70.68543058
63SGK30.68212995
64BRAF0.65818097
65YES10.64701716
66LRRK20.64280960
67TRIB30.63371107
68STK380.62814610
69MAP3K20.61124764
70TSSK60.60371236
71TLK10.58766722
72EIF2AK30.57938369
73HIPK20.55776053
74MAP2K30.55493860
75SGK2230.53970701
76SGK4940.53970701
77TNIK0.53471958
78RAF10.52600392
79INSR0.51176322
80CLK10.51011209
81CSF1R0.50681242
82MAP3K60.50607690
83MAP3K50.49828678
84NUAK10.49414377
85TYRO30.48982617
86ERN10.48444659
87NTRK20.48002551
88PIK3CG0.47679549
89MARK30.47208458
90FLT30.45362126
91FGFR10.44860521
92FYN0.44125084
93STK160.43579302
94RPS6KA50.43250975
95FES0.43147803
96PDK10.41732825
97IGF1R0.41107673
98FGFR20.40321278
99MAPK70.37884440
100PRKD20.37213971
101CDK120.36283320
102PIM20.35183188
103MAP3K30.35076572
104ADRBK20.34385493
105ALK0.34012343
106SIK20.32525603
107MAPKAPK20.32441570
108EPHB10.31202794
109EPHA30.31157452
110KSR20.30189670
111MAP2K60.29981738
112RIPK10.29268051
113MAPK110.28544077
114SCYL20.28262321
115MELK0.27975262
116CDK40.27420043
117MAP3K120.27292739
118TRIM280.26480788
119MAPK30.25829338
120CDK90.25516642
121MARK20.25013873
122TRPM70.24627613
123VRK10.24536761
124LIMK10.22441806
125EGFR0.21584982
126DYRK1B0.20490526
127BRD40.19775409
128MAP3K10.17938551
129MAP3K80.17910562
130STK40.16956141
131MAPK120.16950522
132NME10.14736200

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.72915359
2T cell receptor signaling pathway_Homo sapiens_hsa046604.37658593
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.55795902
4Measles_Homo sapiens_hsa051623.02763539
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.01487329
6Allograft rejection_Homo sapiens_hsa053302.80088937
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.71290832
8Hematopoietic cell lineage_Homo sapiens_hsa046402.65064569
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.61967989
10Autoimmune thyroid disease_Homo sapiens_hsa053202.38583626
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15489263
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.08728176
13Viral myocarditis_Homo sapiens_hsa054162.02552646
14Graft-versus-host disease_Homo sapiens_hsa053322.01961359
15Antigen processing and presentation_Homo sapiens_hsa046122.01838266
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.80842169
17Leishmaniasis_Homo sapiens_hsa051401.67697775
18Osteoclast differentiation_Homo sapiens_hsa043801.62986451
19Herpes simplex infection_Homo sapiens_hsa051681.54740458
20Ribosome_Homo sapiens_hsa030101.51187533
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.49565500
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39578426
23Asthma_Homo sapiens_hsa053101.35629700
24Hepatitis B_Homo sapiens_hsa051611.34879584
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34173587
26Proteasome_Homo sapiens_hsa030501.31436951
27Type I diabetes mellitus_Homo sapiens_hsa049401.30092172
28Acute myeloid leukemia_Homo sapiens_hsa052211.28202776
29B cell receptor signaling pathway_Homo sapiens_hsa046621.27554587
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24679068
31Spliceosome_Homo sapiens_hsa030401.21148642
32HTLV-I infection_Homo sapiens_hsa051661.17020257
33Chemokine signaling pathway_Homo sapiens_hsa040621.13388067
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10868508
35Toxoplasmosis_Homo sapiens_hsa051451.10755393
36Protein export_Homo sapiens_hsa030601.07728052
37Shigellosis_Homo sapiens_hsa051311.06744850
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06408437
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.04169849
40Non-homologous end-joining_Homo sapiens_hsa034501.01658185
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00907587
42Influenza A_Homo sapiens_hsa051640.96832462
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95185082
44Regulation of autophagy_Homo sapiens_hsa041400.93646848
45Thyroid cancer_Homo sapiens_hsa052160.92422921
46Sulfur relay system_Homo sapiens_hsa041220.91259138
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87725985
48Epstein-Barr virus infection_Homo sapiens_hsa051690.86959989
49Staphylococcus aureus infection_Homo sapiens_hsa051500.85468239
50Apoptosis_Homo sapiens_hsa042100.84680132
51Hepatitis C_Homo sapiens_hsa051600.83665659
52TNF signaling pathway_Homo sapiens_hsa046680.82954975
53African trypanosomiasis_Homo sapiens_hsa051430.80906387
54Prolactin signaling pathway_Homo sapiens_hsa049170.77801528
55Legionellosis_Homo sapiens_hsa051340.74545960
56Viral carcinogenesis_Homo sapiens_hsa052030.74178797
57Colorectal cancer_Homo sapiens_hsa052100.72799815
58Other glycan degradation_Homo sapiens_hsa005110.72097889
59p53 signaling pathway_Homo sapiens_hsa041150.65369099
60Chronic myeloid leukemia_Homo sapiens_hsa052200.63870836
61Pancreatic cancer_Homo sapiens_hsa052120.63499740
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62675899
63RNA degradation_Homo sapiens_hsa030180.61882303
64Long-term potentiation_Homo sapiens_hsa047200.60940586
65Nucleotide excision repair_Homo sapiens_hsa034200.60932033
66VEGF signaling pathway_Homo sapiens_hsa043700.60911431
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57546905
68Tuberculosis_Homo sapiens_hsa051520.57307309
69DNA replication_Homo sapiens_hsa030300.57073897
70Malaria_Homo sapiens_hsa051440.53772294
71Platelet activation_Homo sapiens_hsa046110.53358035
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51400763
73Renal cell carcinoma_Homo sapiens_hsa052110.50569159
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49028888
75Salmonella infection_Homo sapiens_hsa051320.49023400
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45207292
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44475292
78Base excision repair_Homo sapiens_hsa034100.43900926
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42030599
80Phagosome_Homo sapiens_hsa041450.41679214
81RNA polymerase_Homo sapiens_hsa030200.40940966
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.40811333
83RNA transport_Homo sapiens_hsa030130.40649868
84Mismatch repair_Homo sapiens_hsa034300.39761565
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38600014
86Pertussis_Homo sapiens_hsa051330.37803947
87Inositol phosphate metabolism_Homo sapiens_hsa005620.36444910
88Insulin resistance_Homo sapiens_hsa049310.33427690
89Ras signaling pathway_Homo sapiens_hsa040140.30974760
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.30416152
91mTOR signaling pathway_Homo sapiens_hsa041500.30413903
92mRNA surveillance pathway_Homo sapiens_hsa030150.30330074
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28453160
94One carbon pool by folate_Homo sapiens_hsa006700.28223337
95Endocytosis_Homo sapiens_hsa041440.27713270
96Small cell lung cancer_Homo sapiens_hsa052220.27673812
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.26942218
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.26094356
99Rheumatoid arthritis_Homo sapiens_hsa053230.26053549
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.25831765
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25223846
102Rap1 signaling pathway_Homo sapiens_hsa040150.24767376
103Endometrial cancer_Homo sapiens_hsa052130.23806574
104Prostate cancer_Homo sapiens_hsa052150.23620186
105Notch signaling pathway_Homo sapiens_hsa043300.23094377
106Circadian rhythm_Homo sapiens_hsa047100.22598112
107MAPK signaling pathway_Homo sapiens_hsa040100.21660240
108Pentose phosphate pathway_Homo sapiens_hsa000300.20094307
109Pyrimidine metabolism_Homo sapiens_hsa002400.19840551
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18765628
111Amphetamine addiction_Homo sapiens_hsa050310.18586354
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18578119
113FoxO signaling pathway_Homo sapiens_hsa040680.18542498
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18238457
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.17217024
116HIF-1 signaling pathway_Homo sapiens_hsa040660.16917306
117Non-small cell lung cancer_Homo sapiens_hsa052230.16203404
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14556121
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14013750
120Choline metabolism in cancer_Homo sapiens_hsa052310.11167029
121Homologous recombination_Homo sapiens_hsa034400.10308983

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »