

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 8.48463210 |
| 2 | negative thymic T cell selection (GO:0045060) | 8.20336389 |
| 3 | positive thymic T cell selection (GO:0045059) | 7.94656837 |
| 4 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.52219501 |
| 5 | positive T cell selection (GO:0043368) | 7.46858983 |
| 6 | thymic T cell selection (GO:0045061) | 7.31375763 |
| 7 | negative regulation of cell killing (GO:0031342) | 7.26266389 |
| 8 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 7.26266389 |
| 9 | regulation of gamma-delta T cell differentiation (GO:0045586) | 7.04343341 |
| 10 | T cell selection (GO:0045058) | 6.82320970 |
| 11 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.72473110 |
| 12 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 6.69321570 |
| 13 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.40388556 |
| 14 | regulation of gamma-delta T cell activation (GO:0046643) | 6.26040040 |
| 15 | response to interleukin-15 (GO:0070672) | 6.20658363 |
| 16 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.15448578 |
| 17 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.15448578 |
| 18 | cellular response to interleukin-15 (GO:0071350) | 6.08895655 |
| 19 | T cell receptor signaling pathway (GO:0050852) | 5.97001720 |
| 20 | leukocyte aggregation (GO:0070486) | 5.72184305 |
| 21 | T cell costimulation (GO:0031295) | 5.57824348 |
| 22 | interferon-gamma production (GO:0032609) | 5.52904658 |
| 23 | lymphocyte costimulation (GO:0031294) | 5.52184254 |
| 24 | regulation of T cell tolerance induction (GO:0002664) | 5.48624257 |
| 25 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.13995898 |
| 26 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.99511222 |
| 27 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.97713507 |
| 28 | positive regulation of B cell differentiation (GO:0045579) | 4.94759242 |
| 29 | T cell migration (GO:0072678) | 4.85434001 |
| 30 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.82343132 |
| 31 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 4.70576242 |
| 32 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.61824551 |
| 33 | regulation of regulatory T cell differentiation (GO:0045589) | 4.59576149 |
| 34 | positive regulation of tolerance induction (GO:0002645) | 4.57259489 |
| 35 | sequestering of actin monomers (GO:0042989) | 4.53334743 |
| 36 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.50359250 |
| 37 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.43784887 |
| 38 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.38472260 |
| 39 | activated T cell proliferation (GO:0050798) | 4.32058593 |
| 40 | regulation of B cell differentiation (GO:0045577) | 4.25926333 |
| 41 | positive regulation of interleukin-2 production (GO:0032743) | 4.25808182 |
| 42 | regulation of isotype switching (GO:0045191) | 4.15509651 |
| 43 | tolerance induction (GO:0002507) | 4.06549336 |
| 44 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.04379407 |
| 45 | positive regulation of granulocyte differentiation (GO:0030854) | 4.04143392 |
| 46 | negative regulation of T cell mediated immunity (GO:0002710) | 4.02190529 |
| 47 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.00441908 |
| 48 | T cell differentiation (GO:0030217) | 3.97709642 |
| 49 | regulation of tolerance induction (GO:0002643) | 3.94281446 |
| 50 | NIK/NF-kappaB signaling (GO:0038061) | 3.84735479 |
| 51 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.81796000 |
| 52 | mast cell activation (GO:0045576) | 3.81627088 |
| 53 | positive regulation of humoral immune response (GO:0002922) | 3.79533380 |
| 54 | alpha-beta T cell differentiation (GO:0046632) | 3.78923419 |
| 55 | positive regulation of isotype switching (GO:0045830) | 3.72815785 |
| 56 | regulation of response to interferon-gamma (GO:0060330) | 3.72099263 |
| 57 | natural killer cell differentiation (GO:0001779) | 3.70963649 |
| 58 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.70737730 |
| 59 | regulation of B cell mediated immunity (GO:0002712) | 3.67772585 |
| 60 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.66747223 |
| 61 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.66599013 |
| 62 | T cell activation (GO:0042110) | 3.65338901 |
| 63 | alpha-beta T cell activation (GO:0046631) | 3.65276391 |
| 64 | regulation of immunoglobulin production (GO:0002637) | 3.59777286 |
| 65 | positive regulation of B cell mediated immunity (GO:0002714) | 3.56948362 |
| 66 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.56948362 |
| 67 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.56814536 |
| 68 | regulation of interleukin-4 production (GO:0032673) | 3.55163731 |
| 69 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.53870454 |
| 70 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.52648369 |
| 71 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.52161401 |
| 72 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.49172786 |
| 73 | regulation of defense response to virus by virus (GO:0050690) | 3.48817072 |
| 74 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.46611001 |
| 75 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.44853106 |
| 76 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.40155042 |
| 77 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.40155042 |
| 78 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 3.39154875 |
| 79 | negative regulation of T cell apoptotic process (GO:0070233) | 3.38371881 |
| 80 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 3.36777209 |
| 81 | immunoglobulin mediated immune response (GO:0016064) | 3.35324478 |
| 82 | T cell homeostasis (GO:0043029) | 3.33987131 |
| 83 | response to type I interferon (GO:0034340) | 3.33212434 |
| 84 | negative regulation of interleukin-12 production (GO:0032695) | 3.32416218 |
| 85 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.31044385 |
| 86 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.30700131 |
| 87 | V(D)J recombination (GO:0033151) | 3.29613043 |
| 88 | positive regulation of interleukin-4 production (GO:0032753) | 3.29539593 |
| 89 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.28852526 |
| 90 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.28852526 |
| 91 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 3.28053719 |
| 92 | leukocyte cell-cell adhesion (GO:0007159) | 3.27838849 |
| 93 | B cell receptor signaling pathway (GO:0050853) | 3.26409972 |
| 94 | positive regulation of DNA recombination (GO:0045911) | 3.26288074 |
| 95 | type I interferon signaling pathway (GO:0060337) | 3.25037372 |
| 96 | cellular response to type I interferon (GO:0071357) | 3.25037372 |
| 97 | natural killer cell activation (GO:0030101) | 3.24070429 |
| 98 | positive regulation of T cell activation (GO:0050870) | 3.22567222 |
| 99 | regulation of alpha-beta T cell activation (GO:0046634) | 3.20272372 |
| 100 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.19965916 |
| 101 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.18386581 |
| 102 | positive regulation of immunoglobulin production (GO:0002639) | 3.18178761 |
| 103 | DNA deamination (GO:0045006) | 3.15895249 |
| 104 | cellular response to interferon-beta (GO:0035458) | 3.15698204 |
| 105 | lymphocyte homeostasis (GO:0002260) | 3.15016147 |
| 106 | regulation of cell killing (GO:0031341) | 3.13253566 |
| 107 | regulation of interleukin-2 production (GO:0032663) | 3.13013304 |
| 108 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 3.12491892 |
| 109 | negative regulation of B cell mediated immunity (GO:0002713) | 3.12491892 |
| 110 | heterotypic cell-cell adhesion (GO:0034113) | 3.11111000 |
| 111 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.11005311 |
| 112 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 3.10479728 |
| 113 | positive regulation of alpha-beta T cell activation (GO:0046635) | 3.10065060 |
| 114 | positive regulation of cell killing (GO:0031343) | 3.09850537 |
| 115 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.09046258 |
| 116 | positive regulation of macrophage differentiation (GO:0045651) | 3.08301018 |
| 117 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.06545482 |
| 118 | mast cell activation involved in immune response (GO:0002279) | 3.06216077 |
| 119 | mast cell degranulation (GO:0043303) | 3.06216077 |
| 120 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.04974250 |
| 121 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.04316031 |
| 122 | detection of bacterium (GO:0016045) | 3.02627407 |
| 123 | cellular response to interleukin-4 (GO:0071353) | 3.02063592 |
| 124 | myeloid dendritic cell differentiation (GO:0043011) | 3.01832530 |
| 125 | negative regulation of adaptive immune response (GO:0002820) | 3.01535587 |
| 126 | positive regulation of T cell differentiation in thymus (GO:0033089) | 3.01014617 |
| 127 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 3.00214242 |
| 128 | T-helper cell differentiation (GO:0042093) | 3.00143277 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.11682730 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.91362398 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.05918945 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.98853931 |
| 5 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.78544585 |
| 6 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.66392793 |
| 7 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.59730223 |
| 8 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.59398729 |
| 9 | MYC_22102868_ChIP-Seq_BL_Human | 3.57056251 |
| 10 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.48582116 |
| 11 | MYB_26560356_Chip-Seq_TH2_Human | 3.43497785 |
| 12 | MAF_26560356_Chip-Seq_TH1_Human | 3.10913898 |
| 13 | UTX_26944678_Chip-Seq_JUKART_Human | 2.78938564 |
| 14 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.77330918 |
| 15 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.74855793 |
| 16 | MYB_26560356_Chip-Seq_TH1_Human | 2.74088117 |
| 17 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.72813062 |
| 18 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.67439959 |
| 19 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.41393283 |
| 20 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.38486756 |
| 21 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.19843528 |
| 22 | MAF_26560356_Chip-Seq_TH2_Human | 2.18333147 |
| 23 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.17505560 |
| 24 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.14163513 |
| 25 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.12072048 |
| 26 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.09288266 |
| 27 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.02992731 |
| 28 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.99448183 |
| 29 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.96932390 |
| 30 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.96239221 |
| 31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.91647411 |
| 32 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.79273733 |
| 33 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.78808632 |
| 34 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.76770819 |
| 35 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.75467993 |
| 36 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.70407031 |
| 37 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.67495347 |
| 38 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.64814414 |
| 39 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.61509649 |
| 40 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.56070232 |
| 41 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.55768944 |
| 42 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53496177 |
| 43 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.52734991 |
| 44 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52601182 |
| 45 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.52559176 |
| 46 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.51814321 |
| 47 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.49477596 |
| 48 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.46270740 |
| 49 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.46117072 |
| 50 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.43438191 |
| 51 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.42962183 |
| 52 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40230513 |
| 53 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.32907185 |
| 54 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.28817045 |
| 55 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.27705366 |
| 56 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.26375218 |
| 57 | SPI1_23127762_ChIP-Seq_K562_Human | 1.25460324 |
| 58 | GATA3_26560356_Chip-Seq_TH2_Human | 1.23401587 |
| 59 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.20873835 |
| 60 | GATA1_22025678_ChIP-Seq_K562_Human | 1.18934890 |
| 61 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.17578312 |
| 62 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.16940435 |
| 63 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.15082625 |
| 64 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.14678374 |
| 65 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.14530673 |
| 66 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.13311241 |
| 67 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.09431966 |
| 68 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.06482957 |
| 69 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.06272594 |
| 70 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.02835797 |
| 71 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.02475232 |
| 72 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.02069902 |
| 73 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.01542674 |
| 74 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.98199848 |
| 75 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.98089178 |
| 76 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97852979 |
| 77 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.97378838 |
| 78 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.97100795 |
| 79 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.95042737 |
| 80 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.94787415 |
| 81 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.92489086 |
| 82 | GATA3_26560356_Chip-Seq_TH1_Human | 0.91047351 |
| 83 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.90923321 |
| 84 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.90367668 |
| 85 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.89953162 |
| 86 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89614078 |
| 87 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.89445664 |
| 88 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.88882245 |
| 89 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87285381 |
| 90 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.86573086 |
| 91 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.86316934 |
| 92 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.86190754 |
| 93 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.85879281 |
| 94 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.85622166 |
| 95 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84253502 |
| 96 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.83395334 |
| 97 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.83141893 |
| 98 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.81831390 |
| 99 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.80781636 |
| 100 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.79853850 |
| 101 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.79494222 |
| 102 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.79186272 |
| 103 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.78650203 |
| 104 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.77735154 |
| 105 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.77227998 |
| 106 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.75763108 |
| 107 | GATA1_19941826_ChIP-Seq_K562_Human | 0.75467362 |
| 108 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.75365825 |
| 109 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.75359631 |
| 110 | P300_27268052_Chip-Seq_Bcells_Human | 0.75237707 |
| 111 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.74936605 |
| 112 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.74896850 |
| 113 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.74730408 |
| 114 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.73920599 |
| 115 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.73315549 |
| 116 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.72315493 |
| 117 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.72282049 |
| 118 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.70878891 |
| 119 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.70308809 |
| 120 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.70297050 |
| 121 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.70047488 |
| 122 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.69710822 |
| 123 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.69689183 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.19872888 |
| 2 | MP0005671_abnormal_response_to | 4.98999270 |
| 3 | MP0002166_altered_tumor_susceptibility | 4.24906909 |
| 4 | MP0001835_abnormal_antigen_presentation | 3.54349175 |
| 5 | MP0000685_abnormal_immune_system | 3.54285286 |
| 6 | MP0002006_tumorigenesis | 3.35286099 |
| 7 | MP0001800_abnormal_humoral_immune | 3.18897801 |
| 8 | MP0005387_immune_system_phenotype | 3.08687119 |
| 9 | MP0001790_abnormal_immune_system | 3.08687119 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.93822903 |
| 11 | MP0002398_abnormal_bone_marrow | 2.87534924 |
| 12 | MP0000703_abnormal_thymus_morphology | 2.87450403 |
| 13 | MP0009333_abnormal_splenocyte_physiolog | 2.87076450 |
| 14 | MP0002723_abnormal_immune_serum | 2.85955888 |
| 15 | MP0002420_abnormal_adaptive_immunity | 2.85148785 |
| 16 | MP0001819_abnormal_immune_cell | 2.80860624 |
| 17 | MP0009785_altered_susceptibility_to | 2.80233761 |
| 18 | MP0003724_increased_susceptibility_to | 2.70567881 |
| 19 | MP0003866_abnormal_defecation | 2.63252102 |
| 20 | MP0002405_respiratory_system_inflammati | 2.60817246 |
| 21 | MP0002452_abnormal_antigen_presenting | 2.52253795 |
| 22 | MP0005025_abnormal_response_to | 2.52047658 |
| 23 | MP0000716_abnormal_immune_system | 2.51549929 |
| 24 | MP0002722_abnormal_immune_system | 2.46791564 |
| 25 | MP0001873_stomach_inflammation | 2.43922473 |
| 26 | MP0003436_decreased_susceptibility_to | 2.40084272 |
| 27 | MP0002277_abnormal_respiratory_mucosa | 2.38085779 |
| 28 | MP0003300_gastrointestinal_ulcer | 2.36595067 |
| 29 | MP0002933_joint_inflammation | 2.34772888 |
| 30 | MP0000689_abnormal_spleen_morphology | 2.32888206 |
| 31 | MP0010155_abnormal_intestine_physiology | 2.29730174 |
| 32 | MP0006082_CNS_inflammation | 2.27655731 |
| 33 | MP0004947_skin_inflammation | 2.17877603 |
| 34 | MP0002429_abnormal_blood_cell | 2.01953588 |
| 35 | MP0004510_myositis | 1.97072902 |
| 36 | MP0004381_abnormal_hair_follicle | 1.93213294 |
| 37 | MP0002396_abnormal_hematopoietic_system | 1.83465887 |
| 38 | MP0002148_abnormal_hypersensitivity_rea | 1.76735153 |
| 39 | MP0003303_peritoneal_inflammation | 1.71896783 |
| 40 | MP0002419_abnormal_innate_immunity | 1.68174547 |
| 41 | MP0001845_abnormal_inflammatory_respons | 1.62712693 |
| 42 | MP0001853_heart_inflammation | 1.49286084 |
| 43 | MP0002009_preneoplasia | 1.42764515 |
| 44 | MP0005464_abnormal_platelet_physiology | 1.40962504 |
| 45 | MP0005310_abnormal_salivary_gland | 1.36582963 |
| 46 | MP0000858_altered_metastatic_potential | 1.22871567 |
| 47 | MP0005075_abnormal_melanosome_morpholog | 1.20937978 |
| 48 | MP0008469_abnormal_protein_level | 1.20838557 |
| 49 | MP0004808_abnormal_hematopoietic_stem | 1.20356845 |
| 50 | MP0002132_abnormal_respiratory_system | 1.15215588 |
| 51 | MP0001533_abnormal_skeleton_physiology | 1.08522258 |
| 52 | MP0003191_abnormal_cellular_cholesterol | 1.08475397 |
| 53 | MP0000490_abnormal_crypts_of | 1.04398242 |
| 54 | MP0002019_abnormal_tumor_incidence | 0.98579675 |
| 55 | MP0005379_endocrine/exocrine_gland_phen | 0.94163270 |
| 56 | MP0004883_abnormal_blood_vessel | 0.93479664 |
| 57 | MP0001851_eye_inflammation | 0.92798237 |
| 58 | MP0003448_altered_tumor_morphology | 0.92055973 |
| 59 | MP0008260_abnormal_autophagy | 0.90090802 |
| 60 | MP0002138_abnormal_hepatobiliary_system | 0.88647469 |
| 61 | MP0000465_gastrointestinal_hemorrhage | 0.85512904 |
| 62 | MP0005023_abnormal_wound_healing | 0.84245094 |
| 63 | MP0003828_pulmonary_edema | 0.81908656 |
| 64 | MP0001348_abnormal_lacrimal_gland | 0.81812946 |
| 65 | MP0010352_gastrointestinal_tract_polyps | 0.81513178 |
| 66 | MP0004185_abnormal_adipocyte_glucose | 0.81278150 |
| 67 | MP0002998_abnormal_bone_remodeling | 0.79995143 |
| 68 | MP0010234_abnormal_vibrissa_follicle | 0.78305413 |
| 69 | MP0008961_abnormal_basal_metabolism | 0.76692473 |
| 70 | MP0003172_abnormal_lysosome_physiology | 0.73346025 |
| 71 | MP0005397_hematopoietic_system_phenotyp | 0.71115901 |
| 72 | MP0001545_abnormal_hematopoietic_system | 0.71115901 |
| 73 | MP0003221_abnormal_cardiomyocyte_apopto | 0.69637756 |
| 74 | MP0000477_abnormal_intestine_morphology | 0.69083319 |
| 75 | MP0000249_abnormal_blood_vessel | 0.66967944 |
| 76 | MP0001243_abnormal_dermal_layer | 0.65719969 |
| 77 | MP0009765_abnormal_xenobiotic_induced | 0.65408776 |
| 78 | MP0008569_lethality_at_weaning | 0.63828730 |
| 79 | MP0009763_increased_sensitivity_to | 0.63644869 |
| 80 | MP0002693_abnormal_pancreas_physiology | 0.60674379 |
| 81 | MP0003795_abnormal_bone_structure | 0.60169198 |
| 82 | MP0008057_abnormal_DNA_replication | 0.58748480 |
| 83 | MP0009278_abnormal_bone_marrow | 0.58296442 |
| 84 | MP0000609_abnormal_liver_physiology | 0.57120781 |
| 85 | MP0003453_abnormal_keratinocyte_physiol | 0.55895738 |
| 86 | MP0005164_abnormal_response_to | 0.55122653 |
| 87 | MP0009764_decreased_sensitivity_to | 0.54149873 |
| 88 | MP0005166_decreased_susceptibility_to | 0.53966269 |
| 89 | MP0004957_abnormal_blastocyst_morpholog | 0.52223289 |
| 90 | MP0008058_abnormal_DNA_repair | 0.52083908 |
| 91 | MP0008874_decreased_physiological_sensi | 0.51891695 |
| 92 | MP0005381_digestive/alimentary_phenotyp | 0.50746258 |
| 93 | MP0000604_amyloidosis | 0.50695074 |
| 94 | MP0001663_abnormal_digestive_system | 0.49826295 |
| 95 | MP0004130_abnormal_muscle_cell | 0.48935591 |
| 96 | MP0005451_abnormal_body_composition | 0.47706873 |
| 97 | MP0001986_abnormal_taste_sensitivity | 0.44892144 |
| 98 | MP0001191_abnormal_skin_condition | 0.44844721 |
| 99 | MP0003693_abnormal_embryo_hatching | 0.44436245 |
| 100 | MP0002822_catalepsy | 0.44393741 |
| 101 | MP0008995_early_reproductive_senescence | 0.42832928 |
| 102 | MP0003077_abnormal_cell_cycle | 0.40793923 |
| 103 | MP0005535_abnormal_body_temperature | 0.40627889 |
| 104 | MP0002083_premature_death | 0.40378716 |
| 105 | MP0003252_abnormal_bile_duct | 0.39839730 |
| 106 | MP0005174_abnormal_tail_pigmentation | 0.39814161 |
| 107 | MP0010094_abnormal_chromosome_stability | 0.39568589 |
| 108 | MP0000313_abnormal_cell_death | 0.39049669 |
| 109 | MP0008873_increased_physiological_sensi | 0.38593994 |
| 110 | MP0002136_abnormal_kidney_physiology | 0.38340609 |
| 111 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.37991898 |
| 112 | MP0001919_abnormal_reproductive_system | 0.37041800 |
| 113 | MP0003045_fibrosis | 0.35167308 |
| 114 | MP0000598_abnormal_liver_morphology | 0.34979638 |
| 115 | MP0001216_abnormal_epidermal_layer | 0.34947201 |
| 116 | MP0005390_skeleton_phenotype | 0.34880011 |
| 117 | MP0000367_abnormal_coat/_hair | 0.34489740 |
| 118 | MP0009642_abnormal_blood_homeostasis | 0.33710997 |
| 119 | MP0000015_abnormal_ear_pigmentation | 0.32204656 |
| 120 | MP0002163_abnormal_gland_morphology | 0.31963804 |
| 121 | MP0001881_abnormal_mammary_gland | 0.31728814 |
| 122 | MP0003943_abnormal_hepatobiliary_system | 0.31563371 |
| 123 | MP0009840_abnormal_foam_cell | 0.30771307 |
| 124 | MP0004742_abnormal_vestibular_system | 0.29672970 |
| 125 | MP0001661_extended_life_span | 0.28078633 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 8.50194812 |
| 2 | Abnormality of T cell number (HP:0011839) | 8.23026677 |
| 3 | Elevated erythrocyte sedimentation rate (HP:0003565) | 7.34593352 |
| 4 | Severe combined immunodeficiency (HP:0004430) | 7.29016283 |
| 5 | Combined immunodeficiency (HP:0005387) | 6.58837481 |
| 6 | Abnormality of T cells (HP:0002843) | 5.90569900 |
| 7 | Abnormality of B cell number (HP:0010975) | 5.51917111 |
| 8 | B lymphocytopenia (HP:0010976) | 5.51917111 |
| 9 | Recurrent bronchitis (HP:0002837) | 5.50431395 |
| 10 | Stomatitis (HP:0010280) | 5.12991848 |
| 11 | IgG deficiency (HP:0004315) | 4.86369442 |
| 12 | Recurrent fungal infections (HP:0002841) | 4.54254554 |
| 13 | IgM deficiency (HP:0002850) | 4.52495254 |
| 14 | Panhypogammaglobulinemia (HP:0003139) | 4.51903041 |
| 15 | Thyroiditis (HP:0100646) | 4.48244997 |
| 16 | Autoimmune hemolytic anemia (HP:0001890) | 4.45602971 |
| 17 | Abnormality of eosinophils (HP:0001879) | 4.37944038 |
| 18 | Abnormality of macrophages (HP:0004311) | 4.32491676 |
| 19 | Chronic otitis media (HP:0000389) | 4.31915316 |
| 20 | Recurrent viral infections (HP:0004429) | 4.21682107 |
| 21 | Aplastic anemia (HP:0001915) | 4.17767064 |
| 22 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.14524420 |
| 23 | Recurrent cutaneous fungal infections (HP:0011370) | 4.14524420 |
| 24 | Recurrent bacterial skin infections (HP:0005406) | 4.10703368 |
| 25 | Pustule (HP:0200039) | 4.01917848 |
| 26 | Eczematoid dermatitis (HP:0000976) | 4.00082140 |
| 27 | Myositis (HP:0100614) | 3.95921003 |
| 28 | Chronic diarrhea (HP:0002028) | 3.88425430 |
| 29 | Increased IgM level (HP:0003496) | 3.85664538 |
| 30 | Lymphopenia (HP:0001888) | 3.79183417 |
| 31 | Abnormality of T cell physiology (HP:0011840) | 3.78616273 |
| 32 | Leukocytosis (HP:0001974) | 3.74167428 |
| 33 | Abnormality of the fingertips (HP:0001211) | 3.71008758 |
| 34 | Nasal polyposis (HP:0100582) | 3.69761568 |
| 35 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.67549611 |
| 36 | Hypoplasia of the thymus (HP:0000778) | 3.67448388 |
| 37 | Basal cell carcinoma (HP:0002671) | 3.58843905 |
| 38 | Eosinophilia (HP:0001880) | 3.49761654 |
| 39 | Bronchitis (HP:0012387) | 3.24831557 |
| 40 | Joint swelling (HP:0001386) | 3.19989768 |
| 41 | Abnormality of the nasal mucosa (HP:0000433) | 3.06782331 |
| 42 | Fatigue (HP:0012378) | 3.05238824 |
| 43 | Granulocytopenia (HP:0001913) | 3.03916618 |
| 44 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.03070035 |
| 45 | Lymphoma (HP:0002665) | 2.93805698 |
| 46 | Hypergammaglobulinemia (HP:0010702) | 2.92041950 |
| 47 | Optic neuritis (HP:0100653) | 2.91430102 |
| 48 | Retrobulbar optic neuritis (HP:0100654) | 2.91430102 |
| 49 | Hypochromic microcytic anemia (HP:0004840) | 2.90007313 |
| 50 | Recurrent sinusitis (HP:0011108) | 2.87695169 |
| 51 | IgA deficiency (HP:0002720) | 2.83274830 |
| 52 | Orchitis (HP:0100796) | 2.79116465 |
| 53 | Hypochromic anemia (HP:0001931) | 2.78613804 |
| 54 | Recurrent otitis media (HP:0000403) | 2.73221919 |
| 55 | Gangrene (HP:0100758) | 2.73219798 |
| 56 | Hemoptysis (HP:0002105) | 2.71401727 |
| 57 | Agammaglobulinemia (HP:0004432) | 2.68912325 |
| 58 | Meningitis (HP:0001287) | 2.68022025 |
| 59 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.61668757 |
| 60 | Vasculitis (HP:0002633) | 2.57785894 |
| 61 | Pulmonary infiltrates (HP:0002113) | 2.54391793 |
| 62 | Slow saccadic eye movements (HP:0000514) | 2.44812652 |
| 63 | Papilloma (HP:0012740) | 2.42905996 |
| 64 | Verrucae (HP:0200043) | 2.42905996 |
| 65 | Autoimmune thrombocytopenia (HP:0001973) | 2.38221672 |
| 66 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.37691470 |
| 67 | Chronic sinusitis (HP:0011109) | 2.34326767 |
| 68 | Glomerulopathy (HP:0100820) | 2.34226957 |
| 69 | 3-Methylglutaconic aciduria (HP:0003535) | 2.33605345 |
| 70 | Prolonged bleeding time (HP:0003010) | 2.32652964 |
| 71 | Inflammation of the large intestine (HP:0002037) | 2.32586039 |
| 72 | Entropion (HP:0000621) | 2.31341813 |
| 73 | Poikiloderma (HP:0001029) | 2.29779236 |
| 74 | Anorexia (HP:0002039) | 2.28882419 |
| 75 | Abnormality of the pleura (HP:0002103) | 2.28776852 |
| 76 | Polyneuropathy (HP:0001271) | 2.27880203 |
| 77 | Urticaria (HP:0001025) | 2.27492954 |
| 78 | Thrombocytosis (HP:0001894) | 2.27225070 |
| 79 | Hypoproteinemia (HP:0003075) | 2.25577249 |
| 80 | Seborrheic dermatitis (HP:0001051) | 2.24967096 |
| 81 | Abnormality of the prostate (HP:0008775) | 2.21501453 |
| 82 | Gastrointestinal inflammation (HP:0004386) | 2.18857640 |
| 83 | Recurrent abscess formation (HP:0002722) | 2.18066336 |
| 84 | Cheilitis (HP:0100825) | 2.17362481 |
| 85 | Microcytic anemia (HP:0001935) | 2.15312549 |
| 86 | Spontaneous hematomas (HP:0007420) | 2.14476214 |
| 87 | Recurrent skin infections (HP:0001581) | 2.13202840 |
| 88 | Episodic fever (HP:0001954) | 2.12918472 |
| 89 | Alveolar cell carcinoma (HP:0006519) | 2.10904518 |
| 90 | Keratoconjunctivitis sicca (HP:0001097) | 2.09066888 |
| 91 | Encephalitis (HP:0002383) | 2.05035693 |
| 92 | Mediastinal lymphadenopathy (HP:0100721) | 2.04895943 |
| 93 | Gastrointestinal infarctions (HP:0005244) | 2.03622379 |
| 94 | Papilledema (HP:0001085) | 2.03052435 |
| 95 | Chronic obstructive pulmonary disease (HP:0006510) | 2.01997053 |
| 96 | Obstructive lung disease (HP:0006536) | 2.01997053 |
| 97 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.98703457 |
| 98 | Bronchiectasis (HP:0002110) | 1.96089207 |
| 99 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.95241341 |
| 100 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.94984135 |
| 101 | Ileus (HP:0002595) | 1.94622302 |
| 102 | Gingival bleeding (HP:0000225) | 1.93640157 |
| 103 | Increased IgE level (HP:0003212) | 1.93349661 |
| 104 | Osteomyelitis (HP:0002754) | 1.89505450 |
| 105 | Gastrointestinal stroma tumor (HP:0100723) | 1.87234643 |
| 106 | Keratoconjunctivitis (HP:0001096) | 1.86566966 |
| 107 | Pulmonary embolism (HP:0002204) | 1.85143578 |
| 108 | Amyotrophic lateral sclerosis (HP:0007354) | 1.83762876 |
| 109 | Emphysema (HP:0002097) | 1.82717204 |
| 110 | Epistaxis (HP:0000421) | 1.80915921 |
| 111 | Ureteral stenosis (HP:0000071) | 1.80788535 |
| 112 | Prominent nose (HP:0000448) | 1.80595417 |
| 113 | Skin rash (HP:0000988) | 1.77529790 |
| 114 | Large eyes (HP:0001090) | 1.76145735 |
| 115 | Colitis (HP:0002583) | 1.73874701 |
| 116 | Arterial thrombosis (HP:0004420) | 1.72381038 |
| 117 | Petechiae (HP:0000967) | 1.70829110 |
| 118 | Arthralgia (HP:0002829) | 1.69347336 |
| 119 | Chest pain (HP:0100749) | 1.68790778 |
| 120 | Teleangiectasia of the skin (HP:0100585) | 1.64454396 |
| 121 | Skin ulcer (HP:0200042) | 1.63472087 |
| 122 | Abnormal platelet volume (HP:0011876) | 1.63178455 |
| 123 | Abnormality of the endocardium (HP:0004306) | 1.61753290 |
| 124 | Gingivitis (HP:0000230) | 1.60461382 |
| 125 | Hepatitis (HP:0012115) | 1.60235479 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.37388272 |
| 2 | MAP4K1 | 5.99833563 |
| 3 | IKBKE | 3.71373054 |
| 4 | ZAP70 | 3.54322792 |
| 5 | ITK | 3.25605874 |
| 6 | FGFR4 | 3.20225742 |
| 7 | JAK3 | 2.88422848 |
| 8 | NLK | 2.84088749 |
| 9 | AKT3 | 2.69417563 |
| 10 | TYK2 | 2.54515916 |
| 11 | RIPK4 | 2.46740984 |
| 12 | TESK2 | 2.42616987 |
| 13 | TBK1 | 2.41517280 |
| 14 | KDR | 2.29481821 |
| 15 | SIK3 | 2.24999147 |
| 16 | JAK1 | 2.16306451 |
| 17 | MAP3K14 | 2.14629741 |
| 18 | LCK | 1.92377924 |
| 19 | TEC | 1.84033466 |
| 20 | STK10 | 1.81415529 |
| 21 | FGFR3 | 1.78993603 |
| 22 | GRK6 | 1.73147734 |
| 23 | NME2 | 1.72766344 |
| 24 | TAOK3 | 1.54872051 |
| 25 | SYK | 1.43699469 |
| 26 | HCK | 1.33898760 |
| 27 | MST4 | 1.33065314 |
| 28 | CSK | 1.32760169 |
| 29 | MAP3K11 | 1.29914849 |
| 30 | MAP3K13 | 1.29912256 |
| 31 | IRAK4 | 1.25230577 |
| 32 | CAMKK2 | 1.24675878 |
| 33 | TAOK1 | 1.19879319 |
| 34 | PRKCH | 1.19447624 |
| 35 | TNK2 | 1.18302512 |
| 36 | IKBKB | 1.17637886 |
| 37 | EIF2AK1 | 1.13239659 |
| 38 | PRKCQ | 1.11048308 |
| 39 | BTK | 1.10531722 |
| 40 | KIT | 1.04180582 |
| 41 | SGK2 | 0.95891142 |
| 42 | TAOK2 | 0.93584425 |
| 43 | CHUK | 0.90743564 |
| 44 | CAMKK1 | 0.88230713 |
| 45 | PRPF4B | 0.86213169 |
| 46 | RPS6KA4 | 0.85228379 |
| 47 | EEF2K | 0.83563435 |
| 48 | JAK2 | 0.83153133 |
| 49 | DYRK3 | 0.82778834 |
| 50 | TESK1 | 0.82625975 |
| 51 | FGR | 0.79946981 |
| 52 | MAP3K10 | 0.79320370 |
| 53 | PKN2 | 0.78817561 |
| 54 | PDGFRB | 0.74933996 |
| 55 | BLK | 0.74293606 |
| 56 | LYN | 0.73547769 |
| 57 | PASK | 0.72469871 |
| 58 | IRAK1 | 0.72457969 |
| 59 | IRAK2 | 0.71328303 |
| 60 | GRK7 | 0.70115396 |
| 61 | PIM1 | 0.69269571 |
| 62 | MAP3K7 | 0.68543058 |
| 63 | SGK3 | 0.68212995 |
| 64 | BRAF | 0.65818097 |
| 65 | YES1 | 0.64701716 |
| 66 | LRRK2 | 0.64280960 |
| 67 | TRIB3 | 0.63371107 |
| 68 | STK38 | 0.62814610 |
| 69 | MAP3K2 | 0.61124764 |
| 70 | TSSK6 | 0.60371236 |
| 71 | TLK1 | 0.58766722 |
| 72 | EIF2AK3 | 0.57938369 |
| 73 | HIPK2 | 0.55776053 |
| 74 | MAP2K3 | 0.55493860 |
| 75 | SGK223 | 0.53970701 |
| 76 | SGK494 | 0.53970701 |
| 77 | TNIK | 0.53471958 |
| 78 | RAF1 | 0.52600392 |
| 79 | INSR | 0.51176322 |
| 80 | CLK1 | 0.51011209 |
| 81 | CSF1R | 0.50681242 |
| 82 | MAP3K6 | 0.50607690 |
| 83 | MAP3K5 | 0.49828678 |
| 84 | NUAK1 | 0.49414377 |
| 85 | TYRO3 | 0.48982617 |
| 86 | ERN1 | 0.48444659 |
| 87 | NTRK2 | 0.48002551 |
| 88 | PIK3CG | 0.47679549 |
| 89 | MARK3 | 0.47208458 |
| 90 | FLT3 | 0.45362126 |
| 91 | FGFR1 | 0.44860521 |
| 92 | FYN | 0.44125084 |
| 93 | STK16 | 0.43579302 |
| 94 | RPS6KA5 | 0.43250975 |
| 95 | FES | 0.43147803 |
| 96 | PDK1 | 0.41732825 |
| 97 | IGF1R | 0.41107673 |
| 98 | FGFR2 | 0.40321278 |
| 99 | MAPK7 | 0.37884440 |
| 100 | PRKD2 | 0.37213971 |
| 101 | CDK12 | 0.36283320 |
| 102 | PIM2 | 0.35183188 |
| 103 | MAP3K3 | 0.35076572 |
| 104 | ADRBK2 | 0.34385493 |
| 105 | ALK | 0.34012343 |
| 106 | SIK2 | 0.32525603 |
| 107 | MAPKAPK2 | 0.32441570 |
| 108 | EPHB1 | 0.31202794 |
| 109 | EPHA3 | 0.31157452 |
| 110 | KSR2 | 0.30189670 |
| 111 | MAP2K6 | 0.29981738 |
| 112 | RIPK1 | 0.29268051 |
| 113 | MAPK11 | 0.28544077 |
| 114 | SCYL2 | 0.28262321 |
| 115 | MELK | 0.27975262 |
| 116 | CDK4 | 0.27420043 |
| 117 | MAP3K12 | 0.27292739 |
| 118 | TRIM28 | 0.26480788 |
| 119 | MAPK3 | 0.25829338 |
| 120 | CDK9 | 0.25516642 |
| 121 | MARK2 | 0.25013873 |
| 122 | TRPM7 | 0.24627613 |
| 123 | VRK1 | 0.24536761 |
| 124 | LIMK1 | 0.22441806 |
| 125 | EGFR | 0.21584982 |
| 126 | DYRK1B | 0.20490526 |
| 127 | BRD4 | 0.19775409 |
| 128 | MAP3K1 | 0.17938551 |
| 129 | MAP3K8 | 0.17910562 |
| 130 | STK4 | 0.16956141 |
| 131 | MAPK12 | 0.16950522 |
| 132 | NME1 | 0.14736200 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.72915359 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.37658593 |
| 3 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.55795902 |
| 4 | Measles_Homo sapiens_hsa05162 | 3.02763539 |
| 5 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.01487329 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.80088937 |
| 7 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.71290832 |
| 8 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.65064569 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.61967989 |
| 10 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.38583626 |
| 11 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.15489263 |
| 12 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.08728176 |
| 13 | Viral myocarditis_Homo sapiens_hsa05416 | 2.02552646 |
| 14 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.01961359 |
| 15 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.01838266 |
| 16 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.80842169 |
| 17 | Leishmaniasis_Homo sapiens_hsa05140 | 1.67697775 |
| 18 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.62986451 |
| 19 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.54740458 |
| 20 | Ribosome_Homo sapiens_hsa03010 | 1.51187533 |
| 21 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.49565500 |
| 22 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.39578426 |
| 23 | Asthma_Homo sapiens_hsa05310 | 1.35629700 |
| 24 | Hepatitis B_Homo sapiens_hsa05161 | 1.34879584 |
| 25 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.34173587 |
| 26 | Proteasome_Homo sapiens_hsa03050 | 1.31436951 |
| 27 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.30092172 |
| 28 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.28202776 |
| 29 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.27554587 |
| 30 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.24679068 |
| 31 | Spliceosome_Homo sapiens_hsa03040 | 1.21148642 |
| 32 | HTLV-I infection_Homo sapiens_hsa05166 | 1.17020257 |
| 33 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.13388067 |
| 34 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.10868508 |
| 35 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.10755393 |
| 36 | Protein export_Homo sapiens_hsa03060 | 1.07728052 |
| 37 | Shigellosis_Homo sapiens_hsa05131 | 1.06744850 |
| 38 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.06408437 |
| 39 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.04169849 |
| 40 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.01658185 |
| 41 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.00907587 |
| 42 | Influenza A_Homo sapiens_hsa05164 | 0.96832462 |
| 43 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.95185082 |
| 44 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.93646848 |
| 45 | Thyroid cancer_Homo sapiens_hsa05216 | 0.92422921 |
| 46 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91259138 |
| 47 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.87725985 |
| 48 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.86959989 |
| 49 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.85468239 |
| 50 | Apoptosis_Homo sapiens_hsa04210 | 0.84680132 |
| 51 | Hepatitis C_Homo sapiens_hsa05160 | 0.83665659 |
| 52 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.82954975 |
| 53 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.80906387 |
| 54 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.77801528 |
| 55 | Legionellosis_Homo sapiens_hsa05134 | 0.74545960 |
| 56 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.74178797 |
| 57 | Colorectal cancer_Homo sapiens_hsa05210 | 0.72799815 |
| 58 | Other glycan degradation_Homo sapiens_hsa00511 | 0.72097889 |
| 59 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.65369099 |
| 60 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.63870836 |
| 61 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.63499740 |
| 62 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.62675899 |
| 63 | RNA degradation_Homo sapiens_hsa03018 | 0.61882303 |
| 64 | Long-term potentiation_Homo sapiens_hsa04720 | 0.60940586 |
| 65 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.60932033 |
| 66 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.60911431 |
| 67 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.57546905 |
| 68 | Tuberculosis_Homo sapiens_hsa05152 | 0.57307309 |
| 69 | DNA replication_Homo sapiens_hsa03030 | 0.57073897 |
| 70 | Malaria_Homo sapiens_hsa05144 | 0.53772294 |
| 71 | Platelet activation_Homo sapiens_hsa04611 | 0.53358035 |
| 72 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.51400763 |
| 73 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.50569159 |
| 74 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.49028888 |
| 75 | Salmonella infection_Homo sapiens_hsa05132 | 0.49023400 |
| 76 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.45207292 |
| 77 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.44475292 |
| 78 | Base excision repair_Homo sapiens_hsa03410 | 0.43900926 |
| 79 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.42030599 |
| 80 | Phagosome_Homo sapiens_hsa04145 | 0.41679214 |
| 81 | RNA polymerase_Homo sapiens_hsa03020 | 0.40940966 |
| 82 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.40811333 |
| 83 | RNA transport_Homo sapiens_hsa03013 | 0.40649868 |
| 84 | Mismatch repair_Homo sapiens_hsa03430 | 0.39761565 |
| 85 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.38600014 |
| 86 | Pertussis_Homo sapiens_hsa05133 | 0.37803947 |
| 87 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.36444910 |
| 88 | Insulin resistance_Homo sapiens_hsa04931 | 0.33427690 |
| 89 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.30974760 |
| 90 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.30416152 |
| 91 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.30413903 |
| 92 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.30330074 |
| 93 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.28453160 |
| 94 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.28223337 |
| 95 | Endocytosis_Homo sapiens_hsa04144 | 0.27713270 |
| 96 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.27673812 |
| 97 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.26942218 |
| 98 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.26094356 |
| 99 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.26053549 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.25831765 |
| 101 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.25223846 |
| 102 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.24767376 |
| 103 | Endometrial cancer_Homo sapiens_hsa05213 | 0.23806574 |
| 104 | Prostate cancer_Homo sapiens_hsa05215 | 0.23620186 |
| 105 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.23094377 |
| 106 | Circadian rhythm_Homo sapiens_hsa04710 | 0.22598112 |
| 107 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.21660240 |
| 108 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.20094307 |
| 109 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.19840551 |
| 110 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.18765628 |
| 111 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.18586354 |
| 112 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.18578119 |
| 113 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.18542498 |
| 114 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.18238457 |
| 115 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.17217024 |
| 116 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.16917306 |
| 117 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.16203404 |
| 118 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.14556121 |
| 119 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.14013750 |
| 120 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.11167029 |
| 121 | Homologous recombination_Homo sapiens_hsa03440 | 0.10308983 |

