

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative thymic T cell selection (GO:0045060) | 8.45930708 |
| 2 | negative T cell selection (GO:0043383) | 8.40468070 |
| 3 | positive thymic T cell selection (GO:0045059) | 7.61175996 |
| 4 | regulation of isotype switching to IgG isotypes (GO:0048302) | 7.22540691 |
| 5 | leukocyte aggregation (GO:0070486) | 6.97846306 |
| 6 | positive T cell selection (GO:0043368) | 6.78344501 |
| 7 | thymic T cell selection (GO:0045061) | 6.75658861 |
| 8 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.25416929 |
| 9 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.16082797 |
| 10 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.13627384 |
| 11 | T cell selection (GO:0045058) | 6.11723057 |
| 12 | regulation of T cell tolerance induction (GO:0002664) | 6.05772952 |
| 13 | T cell migration (GO:0072678) | 6.05496300 |
| 14 | interferon-gamma production (GO:0032609) | 5.97864265 |
| 15 | ribosomal small subunit assembly (GO:0000028) | 5.85894448 |
| 16 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 5.78961942 |
| 17 | negative regulation of cell killing (GO:0031342) | 5.74151407 |
| 18 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.74151407 |
| 19 | regulation of alpha-beta T cell proliferation (GO:0046640) | 5.64802817 |
| 20 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.61764075 |
| 21 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 5.56711774 |
| 22 | viral transcription (GO:0019083) | 5.42271975 |
| 23 | regulation of gamma-delta T cell activation (GO:0046643) | 5.38001676 |
| 24 | maturation of SSU-rRNA (GO:0030490) | 5.35638238 |
| 25 | T cell receptor signaling pathway (GO:0050852) | 5.35119688 |
| 26 | antigen processing and presentation via MHC class Ib (GO:0002475) | 5.30885933 |
| 27 | translational termination (GO:0006415) | 5.27603419 |
| 28 | ribosomal small subunit biogenesis (GO:0042274) | 5.24035648 |
| 29 | positive regulation of respiratory burst (GO:0060267) | 5.01377074 |
| 30 | positive regulation of tolerance induction (GO:0002645) | 4.93041205 |
| 31 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 4.87317824 |
| 32 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 4.87317824 |
| 33 | regulation of translation, ncRNA-mediated (GO:0045974) | 4.87317824 |
| 34 | sequestering of actin monomers (GO:0042989) | 4.86075427 |
| 35 | cellular response to interleukin-15 (GO:0071350) | 4.85588686 |
| 36 | response to interleukin-15 (GO:0070672) | 4.82226568 |
| 37 | negative regulation of type 2 immune response (GO:0002829) | 4.77684116 |
| 38 | T cell costimulation (GO:0031295) | 4.74618439 |
| 39 | lymphocyte costimulation (GO:0031294) | 4.65783437 |
| 40 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.57489151 |
| 41 | regulation of translation in response to stress (GO:0043555) | 4.57388468 |
| 42 | regulation of isotype switching (GO:0045191) | 4.45532562 |
| 43 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.43397118 |
| 44 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.28956037 |
| 45 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.26354816 |
| 46 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.26354816 |
| 47 | regulation of tolerance induction (GO:0002643) | 4.25449371 |
| 48 | negative regulation of T cell mediated immunity (GO:0002710) | 4.23652869 |
| 49 | translational elongation (GO:0006414) | 4.21695490 |
| 50 | cellular response to interferon-beta (GO:0035458) | 4.16868161 |
| 51 | cellular protein complex disassembly (GO:0043624) | 4.12434671 |
| 52 | regulation of respiratory burst (GO:0060263) | 4.08674484 |
| 53 | positive regulation of isotype switching (GO:0045830) | 4.05625915 |
| 54 | viral life cycle (GO:0019058) | 4.05605732 |
| 55 | entrainment of circadian clock by photoperiod (GO:0043153) | 4.04319034 |
| 56 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.04131924 |
| 57 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.03895837 |
| 58 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.00679988 |
| 59 | regulation of immunoglobulin production (GO:0002637) | 3.97970250 |
| 60 | positive regulation of interleukin-2 production (GO:0032743) | 3.95447890 |
| 61 | protein targeting to ER (GO:0045047) | 3.92233652 |
| 62 | daunorubicin metabolic process (GO:0044597) | 3.92198960 |
| 63 | polyketide metabolic process (GO:0030638) | 3.92198960 |
| 64 | doxorubicin metabolic process (GO:0044598) | 3.92198960 |
| 65 | cotranslational protein targeting to membrane (GO:0006613) | 3.91885054 |
| 66 | response to interferon-beta (GO:0035456) | 3.87791799 |
| 67 | natural killer cell differentiation (GO:0001779) | 3.87462420 |
| 68 | regulation of immunoglobulin secretion (GO:0051023) | 3.83024738 |
| 69 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.79700324 |
| 70 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.78576257 |
| 71 | positive regulation of B cell differentiation (GO:0045579) | 3.75601846 |
| 72 | hepatocyte apoptotic process (GO:0097284) | 3.73778211 |
| 73 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.72726065 |
| 74 | protein localization to endoplasmic reticulum (GO:0070972) | 3.71622200 |
| 75 | translational initiation (GO:0006413) | 3.70381160 |
| 76 | immunoglobulin mediated immune response (GO:0016064) | 3.67355429 |
| 77 | mitotic cell cycle arrest (GO:0071850) | 3.65511766 |
| 78 | regulation of B cell mediated immunity (GO:0002712) | 3.65088874 |
| 79 | DNA deamination (GO:0045006) | 3.61453267 |
| 80 | negative regulation of interleukin-12 production (GO:0032695) | 3.61208361 |
| 81 | detection of bacterium (GO:0016045) | 3.60171299 |
| 82 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.59503336 |
| 83 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.58624677 |
| 84 | positive regulation of B cell mediated immunity (GO:0002714) | 3.58624677 |
| 85 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.58206860 |
| 86 | leukocyte cell-cell adhesion (GO:0007159) | 3.58022912 |
| 87 | type I interferon signaling pathway (GO:0060337) | 3.57869851 |
| 88 | cellular response to type I interferon (GO:0071357) | 3.57869851 |
| 89 | regulation of response to interferon-gamma (GO:0060330) | 3.55850473 |
| 90 | positive regulation of DNA recombination (GO:0045911) | 3.55182916 |
| 91 | response to type I interferon (GO:0034340) | 3.52582000 |
| 92 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.49885235 |
| 93 | activated T cell proliferation (GO:0050798) | 3.49051843 |
| 94 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.48483938 |
| 95 | protein complex disassembly (GO:0043241) | 3.46568016 |
| 96 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.45676650 |
| 97 | positive regulation of granulocyte differentiation (GO:0030854) | 3.45443249 |
| 98 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.44803151 |
| 99 | lymphocyte migration (GO:0072676) | 3.42325883 |
| 100 | detection of other organism (GO:0098543) | 3.41884667 |
| 101 | regulation of regulatory T cell differentiation (GO:0045589) | 3.40093546 |
| 102 | regulation of B cell differentiation (GO:0045577) | 3.39698131 |
| 103 | granulocyte activation (GO:0036230) | 3.39274898 |
| 104 | mast cell activation (GO:0045576) | 3.38130810 |
| 105 | regulation of chronic inflammatory response (GO:0002676) | 3.37561082 |
| 106 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.37096945 |
| 107 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.34998414 |
| 108 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.34998414 |
| 109 | positive regulation of T cell differentiation in thymus (GO:0033089) | 3.33894235 |
| 110 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.33796484 |
| 111 | positive regulation of humoral immune response (GO:0002922) | 3.33763184 |
| 112 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.32560805 |
| 113 | T cell differentiation (GO:0030217) | 3.30285797 |
| 114 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.26900732 |
| 115 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.26900732 |
| 116 | modulation by symbiont of host immune response (GO:0052553) | 3.26900732 |
| 117 | positive regulation by symbiont of host defense response (GO:0052509) | 3.26900732 |
| 118 | modulation by symbiont of host defense response (GO:0052031) | 3.26900732 |
| 119 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.26900732 |
| 120 | positive regulation of defense response to virus by host (GO:0002230) | 3.26711442 |
| 121 | positive regulation of macrophage differentiation (GO:0045651) | 3.26204965 |
| 122 | cellular defense response (GO:0006968) | 3.26100745 |
| 123 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.24707194 |
| 124 | regulation of defense response to virus by virus (GO:0050690) | 3.23036995 |
| 125 | B cell mediated immunity (GO:0019724) | 3.22794226 |
| 126 | tolerance induction (GO:0002507) | 3.22733556 |
| 127 | positive regulation of interferon-gamma production (GO:0032729) | 3.21782896 |
| 128 | alpha-beta T cell differentiation (GO:0046632) | 3.20003695 |
| 129 | macromolecular complex disassembly (GO:0032984) | 3.17088117 |
| 130 | tumor necrosis factor-mediated signaling pathway (GO:0033209) | 3.16942487 |
| 131 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.13043007 |
| 132 | T cell homeostasis (GO:0043029) | 3.12503596 |
| 133 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.12267795 |
| 134 | positive regulation of interleukin-4 production (GO:0032753) | 3.11863352 |
| 135 | alpha-beta T cell activation (GO:0046631) | 3.11842012 |
| 136 | neutrophil activation involved in immune response (GO:0002283) | 3.09381198 |
| 137 | B cell receptor signaling pathway (GO:0050853) | 3.06671026 |
| 138 | angiogenesis involved in wound healing (GO:0060055) | 3.05859504 |
| 139 | negative regulation of innate immune response (GO:0045824) | 3.01738695 |
| 140 | leukocyte degranulation (GO:0043299) | 3.01315042 |
| 141 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.01113139 |
| 142 | megakaryocyte development (GO:0035855) | 2.99312899 |
| 143 | detection of external biotic stimulus (GO:0098581) | 2.99054654 |
| 144 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.98542470 |
| 145 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.96488521 |
| 146 | myeloid cell activation involved in immune response (GO:0002275) | 2.95368423 |
| 147 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 2.93466897 |
| 148 | positive regulation of interleukin-17 production (GO:0032740) | 2.92460464 |
| 149 | regulation of interleukin-4 production (GO:0032673) | 2.91888227 |
| 150 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.90935673 |
| 151 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 2.90407269 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.80145996 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 7.32994985 |
| 3 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.50891408 |
| 4 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 4.33061547 |
| 5 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 4.30988909 |
| 6 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.26670195 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.15778957 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.00775268 |
| 9 | MYC_22102868_ChIP-Seq_BL_Human | 3.57932135 |
| 10 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.46479717 |
| 11 | MAF_26560356_Chip-Seq_TH1_Human | 3.09999214 |
| 12 | UTX_26944678_Chip-Seq_JUKART_Human | 2.88224467 |
| 13 | MYB_26560356_Chip-Seq_TH2_Human | 2.87058658 |
| 14 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.74518492 |
| 15 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.62930418 |
| 16 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.60866295 |
| 17 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.52654476 |
| 18 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.32403668 |
| 19 | MYB_26560356_Chip-Seq_TH1_Human | 2.32090332 |
| 20 | MAF_26560356_Chip-Seq_TH2_Human | 2.16375214 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.16201240 |
| 22 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.06914857 |
| 23 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.02799001 |
| 24 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.93615590 |
| 25 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.92165839 |
| 26 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.87383047 |
| 27 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.79623443 |
| 28 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.77252460 |
| 29 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.73333684 |
| 30 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.72702267 |
| 31 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.72280104 |
| 32 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.67698321 |
| 33 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.66858615 |
| 34 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.65187036 |
| 35 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.64420602 |
| 36 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.62226844 |
| 37 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.58238458 |
| 38 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.57676953 |
| 39 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.57049682 |
| 40 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.56464966 |
| 41 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.55508650 |
| 42 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.54746729 |
| 43 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.52217906 |
| 44 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.50022440 |
| 45 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.48269271 |
| 46 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.47681984 |
| 47 | SPI1_23127762_ChIP-Seq_K562_Human | 1.44644558 |
| 48 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.41128241 |
| 49 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38972387 |
| 50 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.38962754 |
| 51 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.35031192 |
| 52 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.34957951 |
| 53 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.32109565 |
| 54 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.31721528 |
| 55 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.29310233 |
| 56 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.28157566 |
| 57 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.27725026 |
| 58 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.26787502 |
| 59 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.26296514 |
| 60 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.21661096 |
| 61 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.21593680 |
| 62 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.20898911 |
| 63 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.18770868 |
| 64 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.16601347 |
| 65 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.14250238 |
| 66 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.14055288 |
| 67 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.13838784 |
| 68 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.13749693 |
| 69 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.11326237 |
| 70 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.10749099 |
| 71 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.09748750 |
| 72 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.09741358 |
| 73 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.07640040 |
| 74 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05286246 |
| 75 | GATA3_26560356_Chip-Seq_TH2_Human | 1.03705271 |
| 76 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.01774038 |
| 77 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01697043 |
| 78 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.00677436 |
| 79 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.98925833 |
| 80 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.98730741 |
| 81 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.97936579 |
| 82 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.96383377 |
| 83 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.95101794 |
| 84 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.93747898 |
| 85 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.93526055 |
| 86 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.90723344 |
| 87 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.89938905 |
| 88 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.88319544 |
| 89 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.87318736 |
| 90 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.86587885 |
| 91 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.85869808 |
| 92 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.85553923 |
| 93 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.84873947 |
| 94 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.84128952 |
| 95 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.83964688 |
| 96 | GATA3_26560356_Chip-Seq_TH1_Human | 0.83905222 |
| 97 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.83899889 |
| 98 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83746651 |
| 99 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.83582939 |
| 100 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.81653359 |
| 101 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.81310470 |
| 102 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.80669806 |
| 103 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.80474019 |
| 104 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.79880875 |
| 105 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.79210710 |
| 106 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.78553930 |
| 107 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.78499035 |
| 108 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.78479287 |
| 109 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.77556595 |
| 110 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.77249599 |
| 111 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.76022596 |
| 112 | GATA1_19941826_ChIP-Seq_K562_Human | 0.75150913 |
| 113 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.74973560 |
| 114 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.74031256 |
| 115 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.73848328 |
| 116 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.73812436 |
| 117 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.72806925 |
| 118 | FLI1_21867929_ChIP-Seq_CD8_Mouse | 0.72786834 |
| 119 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.72699135 |
| 120 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.72596105 |
| 121 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.70863876 |
| 122 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.70666762 |
| 123 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.66825591 |
| 124 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.66727711 |
| 125 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.64813395 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 5.44882804 |
| 2 | MP0009379_abnormal_foot_pigmentation | 5.04880904 |
| 3 | MP0010234_abnormal_vibrissa_follicle | 4.35551307 |
| 4 | MP0005671_abnormal_response_to | 3.91477141 |
| 5 | MP0003724_increased_susceptibility_to | 3.62411327 |
| 6 | MP0000685_abnormal_immune_system | 3.38413797 |
| 7 | MP0009785_altered_susceptibility_to | 3.24583500 |
| 8 | MP0000569_abnormal_digit_pigmentation | 3.05942859 |
| 9 | MP0003436_decreased_susceptibility_to | 3.01841691 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.88061432 |
| 11 | MP0002166_altered_tumor_susceptibility | 2.85659684 |
| 12 | MP0001800_abnormal_humoral_immune | 2.84559307 |
| 13 | MP0009333_abnormal_splenocyte_physiolog | 2.77863983 |
| 14 | MP0001835_abnormal_antigen_presentation | 2.74413150 |
| 15 | MP0009840_abnormal_foam_cell | 2.65646025 |
| 16 | MP0004510_myositis | 2.64071779 |
| 17 | MP0002723_abnormal_immune_serum | 2.61986655 |
| 18 | MP0002420_abnormal_adaptive_immunity | 2.55587356 |
| 19 | MP0005387_immune_system_phenotype | 2.53226313 |
| 20 | MP0001790_abnormal_immune_system | 2.53226313 |
| 21 | MP0001819_abnormal_immune_cell | 2.51421290 |
| 22 | MP0002398_abnormal_bone_marrow | 2.50170092 |
| 23 | MP0002006_tumorigenesis | 2.42323520 |
| 24 | MP0005025_abnormal_response_to | 2.35327809 |
| 25 | MP0000703_abnormal_thymus_morphology | 2.34058788 |
| 26 | MP0002405_respiratory_system_inflammati | 2.30786627 |
| 27 | MP0003866_abnormal_defecation | 2.29439367 |
| 28 | MP0006082_CNS_inflammation | 2.19817559 |
| 29 | MP0000716_abnormal_immune_system | 2.19766316 |
| 30 | MP0002452_abnormal_antigen_presenting | 2.18604011 |
| 31 | MP0002933_joint_inflammation | 2.03285977 |
| 32 | MP0002722_abnormal_immune_system | 2.03273462 |
| 33 | MP0004947_skin_inflammation | 1.99832701 |
| 34 | MP0003300_gastrointestinal_ulcer | 1.98859567 |
| 35 | MP0010155_abnormal_intestine_physiology | 1.96180061 |
| 36 | MP0000689_abnormal_spleen_morphology | 1.87664157 |
| 37 | MP0002429_abnormal_blood_cell | 1.70136753 |
| 38 | MP0003453_abnormal_keratinocyte_physiol | 1.68916402 |
| 39 | MP0003303_peritoneal_inflammation | 1.68045795 |
| 40 | MP0002148_abnormal_hypersensitivity_rea | 1.65584937 |
| 41 | MP0003329_amyloid_beta_deposits | 1.63395724 |
| 42 | MP0002277_abnormal_respiratory_mucosa | 1.55439689 |
| 43 | MP0000604_amyloidosis | 1.52614117 |
| 44 | MP0002419_abnormal_innate_immunity | 1.50934575 |
| 45 | MP0001873_stomach_inflammation | 1.49218871 |
| 46 | MP0002102_abnormal_ear_morphology | 1.47390151 |
| 47 | MP0009764_decreased_sensitivity_to | 1.46827739 |
| 48 | MP0001845_abnormal_inflammatory_respons | 1.45019098 |
| 49 | MP0002396_abnormal_hematopoietic_system | 1.44705869 |
| 50 | MP0005464_abnormal_platelet_physiology | 1.40208375 |
| 51 | MP0004381_abnormal_hair_follicle | 1.39762997 |
| 52 | MP0004145_abnormal_muscle_electrophysio | 1.32753935 |
| 53 | MP0005174_abnormal_tail_pigmentation | 1.31741421 |
| 54 | MP0000858_altered_metastatic_potential | 1.30819431 |
| 55 | MP0002998_abnormal_bone_remodeling | 1.29518319 |
| 56 | MP0005023_abnormal_wound_healing | 1.28232830 |
| 57 | MP0008260_abnormal_autophagy | 1.28019484 |
| 58 | MP0000383_abnormal_hair_follicle | 1.21745394 |
| 59 | MP0001853_heart_inflammation | 1.19411099 |
| 60 | MP0003448_altered_tumor_morphology | 1.18600209 |
| 61 | MP0000465_gastrointestinal_hemorrhage | 1.17237567 |
| 62 | MP0001533_abnormal_skeleton_physiology | 1.15474411 |
| 63 | MP0004808_abnormal_hematopoietic_stem | 1.14343576 |
| 64 | MP0008469_abnormal_protein_level | 1.13749543 |
| 65 | MP0000015_abnormal_ear_pigmentation | 1.13289275 |
| 66 | MP0001348_abnormal_lacrimal_gland | 1.11879270 |
| 67 | MP0002138_abnormal_hepatobiliary_system | 1.09477091 |
| 68 | MP0003172_abnormal_lysosome_physiology | 1.07139483 |
| 69 | MP0005310_abnormal_salivary_gland | 1.05306823 |
| 70 | MP0003787_abnormal_imprinting | 0.99380754 |
| 71 | MP0001851_eye_inflammation | 0.92333240 |
| 72 | MP0005058_abnormal_lysosome_morphology | 0.89558906 |
| 73 | MP0008877_abnormal_DNA_methylation | 0.89099284 |
| 74 | MP0003045_fibrosis | 0.86911413 |
| 75 | MP0002877_abnormal_melanocyte_morpholog | 0.85517654 |
| 76 | MP0002822_catalepsy | 0.84675109 |
| 77 | MP0003315_abnormal_perineum_morphology | 0.83967534 |
| 78 | MP0005083_abnormal_biliary_tract | 0.77713039 |
| 79 | MP0002019_abnormal_tumor_incidence | 0.77170073 |
| 80 | MP0003806_abnormal_nucleotide_metabolis | 0.76251356 |
| 81 | MP0003221_abnormal_cardiomyocyte_apopto | 0.74871815 |
| 82 | MP0005408_hypopigmentation | 0.70013170 |
| 83 | MP0008872_abnormal_physiological_respon | 0.68407969 |
| 84 | MP0003795_abnormal_bone_structure | 0.68045980 |
| 85 | MP0003191_abnormal_cellular_cholesterol | 0.67950234 |
| 86 | MP0008961_abnormal_basal_metabolism | 0.65297684 |
| 87 | MP0004134_abnormal_chest_morphology | 0.64934980 |
| 88 | MP0008569_lethality_at_weaning | 0.64641920 |
| 89 | MP0000371_diluted_coat_color | 0.62801066 |
| 90 | MP0009763_increased_sensitivity_to | 0.61103231 |
| 91 | MP0009765_abnormal_xenobiotic_induced | 0.59246432 |
| 92 | MP0010678_abnormal_skin_adnexa | 0.57983709 |
| 93 | MP0001216_abnormal_epidermal_layer | 0.57553140 |
| 94 | MP0002163_abnormal_gland_morphology | 0.56951344 |
| 95 | MP0002089_abnormal_postnatal_growth/wei | 0.56507756 |
| 96 | MP0000343_altered_response_to | 0.55593827 |
| 97 | MP0001243_abnormal_dermal_layer | 0.55537710 |
| 98 | MP0000377_abnormal_hair_follicle | 0.54887086 |
| 99 | MP0005075_abnormal_melanosome_morpholog | 0.54763660 |
| 100 | MP0000490_abnormal_crypts_of | 0.54228384 |
| 101 | MP0005166_decreased_susceptibility_to | 0.53831336 |
| 102 | MP0002132_abnormal_respiratory_system | 0.53655665 |
| 103 | MP0000609_abnormal_liver_physiology | 0.52939585 |
| 104 | MP0005076_abnormal_cell_differentiation | 0.51516935 |
| 105 | MP0005165_increased_susceptibility_to | 0.50594323 |
| 106 | MP0002060_abnormal_skin_morphology | 0.50521338 |
| 107 | MP0002009_preneoplasia | 0.49387626 |
| 108 | MP0004264_abnormal_extraembryonic_tissu | 0.48389309 |
| 109 | MP0005365_abnormal_bile_salt | 0.48367608 |
| 110 | MP0006072_abnormal_retinal_apoptosis | 0.47124811 |
| 111 | MP0001919_abnormal_reproductive_system | 0.46806789 |
| 112 | MP0001191_abnormal_skin_condition | 0.46764705 |
| 113 | MP0002693_abnormal_pancreas_physiology | 0.46588197 |
| 114 | MP0001542_abnormal_bone_strength | 0.44422556 |
| 115 | MP0003633_abnormal_nervous_system | 0.43995145 |
| 116 | MP0003880_abnormal_central_pattern | 0.42996237 |
| 117 | MP0003077_abnormal_cell_cycle | 0.42750354 |
| 118 | MP0000249_abnormal_blood_vessel | 0.40581466 |
| 119 | MP0008057_abnormal_DNA_replication | 0.40281486 |
| 120 | MP0005390_skeleton_phenotype | 0.39151045 |
| 121 | MP0005381_digestive/alimentary_phenotyp | 0.38610281 |
| 122 | MP0003828_pulmonary_edema | 0.37334655 |
| 123 | MP0009931_abnormal_skin_appearance | 0.37234907 |
| 124 | MP0005319_abnormal_enzyme/_coenzyme | 0.37184626 |
| 125 | MP0000477_abnormal_intestine_morphology | 0.36081654 |
| 126 | MP0003075_altered_response_to | 0.35902502 |
| 127 | MP0000313_abnormal_cell_death | 0.34878649 |
| 128 | MP0002136_abnormal_kidney_physiology | 0.34638431 |
| 129 | MP0001663_abnormal_digestive_system | 0.33702645 |
| 130 | MP0000367_abnormal_coat/_hair | 0.33452976 |
| 131 | MP0008873_increased_physiological_sensi | 0.32673737 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Stomatitis (HP:0010280) | 7.09303998 |
| 2 | Severe combined immunodeficiency (HP:0004430) | 6.18193454 |
| 3 | Retrobulbar optic neuritis (HP:0100654) | 6.15615112 |
| 4 | Optic neuritis (HP:0100653) | 6.15615112 |
| 5 | Increased IgM level (HP:0003496) | 5.83085200 |
| 6 | Combined immunodeficiency (HP:0005387) | 5.65453154 |
| 7 | Eczematoid dermatitis (HP:0000976) | 5.62455715 |
| 8 | T lymphocytopenia (HP:0005403) | 5.50439817 |
| 9 | Abnormality of T cell number (HP:0011839) | 5.37924461 |
| 10 | Myositis (HP:0100614) | 5.35256377 |
| 11 | Orchitis (HP:0100796) | 5.25593725 |
| 12 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.24030802 |
| 13 | Panhypogammaglobulinemia (HP:0003139) | 5.05372777 |
| 14 | IgG deficiency (HP:0004315) | 4.60573686 |
| 15 | Recurrent fungal infections (HP:0002841) | 4.46905676 |
| 16 | Abnormality of T cells (HP:0002843) | 4.41041073 |
| 17 | Reticulocytopenia (HP:0001896) | 4.39601789 |
| 18 | Recurrent cutaneous fungal infections (HP:0011370) | 4.19453934 |
| 19 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.19453934 |
| 20 | Keratoconjunctivitis sicca (HP:0001097) | 4.09638997 |
| 21 | Colon cancer (HP:0003003) | 3.86397628 |
| 22 | Keratoconjunctivitis (HP:0001096) | 3.81676063 |
| 23 | Abnormality of macrophages (HP:0004311) | 3.81055601 |
| 24 | Thrombocytosis (HP:0001894) | 3.79160538 |
| 25 | Recurrent bacterial skin infections (HP:0005406) | 3.76088831 |
| 26 | Joint swelling (HP:0001386) | 3.72614898 |
| 27 | Chronic obstructive pulmonary disease (HP:0006510) | 3.70342071 |
| 28 | Obstructive lung disease (HP:0006536) | 3.70342071 |
| 29 | Hemoptysis (HP:0002105) | 3.65230012 |
| 30 | Chest pain (HP:0100749) | 3.64343354 |
| 31 | Recurrent abscess formation (HP:0002722) | 3.63143370 |
| 32 | IgA deficiency (HP:0002720) | 3.44693358 |
| 33 | 11 pairs of ribs (HP:0000878) | 3.30525015 |
| 34 | Abnormality of the prostate (HP:0008775) | 3.29626045 |
| 35 | Pustule (HP:0200039) | 3.26512508 |
| 36 | Abnormality of T cell physiology (HP:0011840) | 3.25830621 |
| 37 | IgM deficiency (HP:0002850) | 3.24620383 |
| 38 | Recurrent bronchitis (HP:0002837) | 3.17484935 |
| 39 | Recurrent viral infections (HP:0004429) | 3.16098006 |
| 40 | Pulmonary infiltrates (HP:0002113) | 3.14991386 |
| 41 | Autoimmune hemolytic anemia (HP:0001890) | 3.07464763 |
| 42 | Hypergammaglobulinemia (HP:0010702) | 2.97977605 |
| 43 | Chronic diarrhea (HP:0002028) | 2.96143240 |
| 44 | Increased IgE level (HP:0003212) | 2.93350592 |
| 45 | Poikiloderma (HP:0001029) | 2.88093459 |
| 46 | Abnormality of eosinophils (HP:0001879) | 2.86530696 |
| 47 | Encephalitis (HP:0002383) | 2.81287123 |
| 48 | Papilloma (HP:0012740) | 2.80337843 |
| 49 | Verrucae (HP:0200043) | 2.80337843 |
| 50 | Albinism (HP:0001022) | 2.76175779 |
| 51 | Papilledema (HP:0001085) | 2.75576675 |
| 52 | Spontaneous hematomas (HP:0007420) | 2.75558769 |
| 53 | Arterial thrombosis (HP:0004420) | 2.73546659 |
| 54 | Pulmonary fibrosis (HP:0002206) | 2.72943082 |
| 55 | Leukocytosis (HP:0001974) | 2.71592333 |
| 56 | Nasal polyposis (HP:0100582) | 2.71282074 |
| 57 | Eosinophilia (HP:0001880) | 2.70789172 |
| 58 | Cheilitis (HP:0100825) | 2.69875882 |
| 59 | Meningitis (HP:0001287) | 2.62574425 |
| 60 | Lymphopenia (HP:0001888) | 2.60412809 |
| 61 | Vasculitis (HP:0002633) | 2.59808412 |
| 62 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.51386636 |
| 63 | Pulmonary embolism (HP:0002204) | 2.51155337 |
| 64 | Gingivitis (HP:0000230) | 2.47970773 |
| 65 | Macrocytic anemia (HP:0001972) | 2.47524209 |
| 66 | Hypochromic anemia (HP:0001931) | 2.44461349 |
| 67 | Aplastic anemia (HP:0001915) | 2.44171775 |
| 68 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.43953264 |
| 69 | Partial duplication of thumb phalanx (HP:0009944) | 2.43737671 |
| 70 | Systemic lupus erythematosus (HP:0002725) | 2.43295506 |
| 71 | Fair hair (HP:0002286) | 2.42816369 |
| 72 | Skin rash (HP:0000988) | 2.41999668 |
| 73 | Gangrene (HP:0100758) | 2.41441455 |
| 74 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.41380396 |
| 75 | Urticaria (HP:0001025) | 2.40278933 |
| 76 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.39533695 |
| 77 | Chronic otitis media (HP:0000389) | 2.35957561 |
| 78 | Glomerulopathy (HP:0100820) | 2.33235683 |
| 79 | Ureteral stenosis (HP:0000071) | 2.32945913 |
| 80 | Ureteral obstruction (HP:0006000) | 2.30063090 |
| 81 | Abnormality of the endocardium (HP:0004306) | 2.29891671 |
| 82 | Abnormality of the nasal mucosa (HP:0000433) | 2.29202228 |
| 83 | Recurrent skin infections (HP:0001581) | 2.28419520 |
| 84 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.27970541 |
| 85 | Osteomyelitis (HP:0002754) | 2.27101853 |
| 86 | Dry hair (HP:0011359) | 2.25432556 |
| 87 | Recurrent sinusitis (HP:0011108) | 2.24908712 |
| 88 | Granulocytopenia (HP:0001913) | 2.23233906 |
| 89 | Epistaxis (HP:0000421) | 2.22649457 |
| 90 | Mucosal telangiectasiae (HP:0100579) | 2.21528992 |
| 91 | Hypochromic microcytic anemia (HP:0004840) | 2.21457287 |
| 92 | Tinnitus (HP:0000360) | 2.21283148 |
| 93 | Abnormality of the pericardium (HP:0001697) | 2.19975935 |
| 94 | Keratitis (HP:0000491) | 2.19329787 |
| 95 | Inflammation of the large intestine (HP:0002037) | 2.15297461 |
| 96 | Multiple enchondromatosis (HP:0005701) | 2.13602543 |
| 97 | Abnormal hair whorl (HP:0010721) | 2.12929968 |
| 98 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.12087389 |
| 99 | Pallor (HP:0000980) | 2.11672301 |
| 100 | Partial duplication of the phalanx of hand (HP:0009999) | 2.11374493 |
| 101 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.10958616 |
| 102 | Petechiae (HP:0000967) | 2.10330448 |
| 103 | Basal ganglia calcification (HP:0002135) | 2.10050627 |
| 104 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.09673845 |
| 105 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.09673845 |
| 106 | Abnormality of glycolipid metabolism (HP:0010969) | 2.09673845 |
| 107 | Mediastinal lymphadenopathy (HP:0100721) | 2.09408814 |
| 108 | Polyneuropathy (HP:0001271) | 2.06827334 |
| 109 | Hemorrhage of the eye (HP:0011885) | 2.04541701 |
| 110 | Neutropenia (HP:0001875) | 2.01788568 |
| 111 | Periodontitis (HP:0000704) | 2.01454170 |
| 112 | Gastrointestinal inflammation (HP:0004386) | 2.01078456 |
| 113 | Abnormal number of erythroid precursors (HP:0012131) | 1.99437388 |
| 114 | B lymphocytopenia (HP:0010976) | 1.98046858 |
| 115 | Abnormality of B cell number (HP:0010975) | 1.98046858 |
| 116 | Hepatitis (HP:0012115) | 1.94634711 |
| 117 | Bronchitis (HP:0012387) | 1.92930889 |
| 118 | Abnormality of the fingertips (HP:0001211) | 1.92892357 |
| 119 | Restrictive lung disease (HP:0002091) | 1.91473840 |
| 120 | Thyroiditis (HP:0100646) | 1.90362684 |
| 121 | Respiratory difficulties (HP:0002880) | 1.90096470 |
| 122 | Recurrent otitis media (HP:0000403) | 1.89317233 |
| 123 | Anorexia (HP:0002039) | 1.88348593 |
| 124 | Hypoplasia of the thymus (HP:0000778) | 1.88093867 |
| 125 | Abnormality of the pleura (HP:0002103) | 1.86022432 |
| 126 | Thrombophlebitis (HP:0004418) | 1.85630887 |
| 127 | Migraine (HP:0002076) | 1.83017476 |
| 128 | Agammaglobulinemia (HP:0004432) | 1.82409901 |
| 129 | Lymphoma (HP:0002665) | 1.80663529 |
| 130 | Hypoproteinemia (HP:0003075) | 1.79592537 |
| 131 | Abnormal platelet volume (HP:0011876) | 1.78646211 |
| 132 | Missing ribs (HP:0000921) | 1.78517015 |
| 133 | Gastrointestinal infarctions (HP:0005244) | 1.78059213 |
| 134 | Acrocyanosis (HP:0001063) | 1.78039203 |
| 135 | Autoimmune thrombocytopenia (HP:0001973) | 1.76191227 |
| 136 | Generalized hypopigmentation of hair (HP:0011358) | 1.74770111 |
| 137 | Increased density of long bones (HP:0006392) | 1.73035333 |
| 138 | Diplopia (HP:0000651) | 1.72250670 |
| 139 | Abnormality of binocular vision (HP:0011514) | 1.72250670 |
| 140 | Abnormality of reticulocytes (HP:0004312) | 1.70243954 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SRPK1 | 7.68869703 |
| 2 | TXK | 7.08570026 |
| 3 | MAP4K1 | 4.45656279 |
| 4 | DAPK2 | 3.66976564 |
| 5 | ZAP70 | 3.37537705 |
| 6 | FGFR4 | 3.24725119 |
| 7 | TYK2 | 2.48747322 |
| 8 | JAK3 | 2.29837375 |
| 9 | MAP3K12 | 2.21868171 |
| 10 | ITK | 2.11208850 |
| 11 | MAP2K6 | 2.03925112 |
| 12 | IKBKE | 1.99357808 |
| 13 | RIPK4 | 1.88155859 |
| 14 | SIK2 | 1.80073535 |
| 15 | CAMKK2 | 1.67063344 |
| 16 | TAOK1 | 1.63775666 |
| 17 | STK16 | 1.59651640 |
| 18 | LCK | 1.55629117 |
| 19 | JAK1 | 1.48936184 |
| 20 | FGFR3 | 1.42697699 |
| 21 | IRAK4 | 1.31794191 |
| 22 | TESK2 | 1.29863472 |
| 23 | BRD4 | 1.27151822 |
| 24 | STK10 | 1.25290099 |
| 25 | PRPF4B | 1.23835656 |
| 26 | CSK | 1.23007705 |
| 27 | TAOK3 | 1.22806366 |
| 28 | MAP3K14 | 1.21218779 |
| 29 | KIT | 1.18623263 |
| 30 | HCK | 1.16525072 |
| 31 | NLK | 1.15763833 |
| 32 | SIK3 | 1.11499590 |
| 33 | NME2 | 1.08618231 |
| 34 | MYLK | 1.07985943 |
| 35 | CDK4 | 1.03554373 |
| 36 | PRKCQ | 1.02323189 |
| 37 | GRK6 | 1.01526604 |
| 38 | BLK | 0.98577596 |
| 39 | TEC | 0.98023151 |
| 40 | TLK1 | 0.97122506 |
| 41 | JAK2 | 0.95990506 |
| 42 | EEF2K | 0.95468336 |
| 43 | SYK | 0.93585871 |
| 44 | PRKCH | 0.90366148 |
| 45 | CAMKK1 | 0.89879151 |
| 46 | KDR | 0.83563880 |
| 47 | NTRK3 | 0.83298913 |
| 48 | TBK1 | 0.83109831 |
| 49 | IKBKB | 0.82353980 |
| 50 | EPHB1 | 0.82156431 |
| 51 | MAPKAPK3 | 0.79743528 |
| 52 | BTK | 0.79121751 |
| 53 | MAP3K13 | 0.78384316 |
| 54 | RPS6KC1 | 0.76967070 |
| 55 | RPS6KL1 | 0.76967070 |
| 56 | PKN2 | 0.76176007 |
| 57 | CDK6 | 0.72294093 |
| 58 | RPS6KA6 | 0.70237039 |
| 59 | MAP3K7 | 0.70205739 |
| 60 | MARK2 | 0.69792657 |
| 61 | LYN | 0.67796601 |
| 62 | CSF1R | 0.67309858 |
| 63 | NEK9 | 0.67215523 |
| 64 | RAF1 | 0.66720855 |
| 65 | FES | 0.65745327 |
| 66 | TRIM28 | 0.65604946 |
| 67 | FGR | 0.64022430 |
| 68 | SIK1 | 0.63058113 |
| 69 | MAPKAPK2 | 0.62713764 |
| 70 | NUAK1 | 0.59771324 |
| 71 | MELK | 0.59199940 |
| 72 | LRRK2 | 0.57942937 |
| 73 | TYRO3 | 0.57562772 |
| 74 | MAP3K10 | 0.56275867 |
| 75 | FYN | 0.56105541 |
| 76 | MAP2K3 | 0.55629721 |
| 77 | DAPK1 | 0.53253494 |
| 78 | CDK9 | 0.51817588 |
| 79 | CHUK | 0.51710287 |
| 80 | CAMK1 | 0.50960576 |
| 81 | CLK1 | 0.48540983 |
| 82 | DMPK | 0.47759635 |
| 83 | EGFR | 0.46873811 |
| 84 | MARK3 | 0.46416361 |
| 85 | ILK | 0.45917497 |
| 86 | RPS6KA2 | 0.45460466 |
| 87 | MAP3K5 | 0.44520805 |
| 88 | INSR | 0.43553015 |
| 89 | CDK19 | 0.42975335 |
| 90 | TNK2 | 0.42632189 |
| 91 | TGFBR2 | 0.41496559 |
| 92 | MAP3K3 | 0.41364610 |
| 93 | DAPK3 | 0.40980341 |
| 94 | MAP3K11 | 0.40923215 |
| 95 | NME1 | 0.40858759 |
| 96 | ROCK2 | 0.40742923 |
| 97 | TTN | 0.39395031 |
| 98 | ZAK | 0.39088022 |
| 99 | PASK | 0.38089038 |
| 100 | MARK1 | 0.36543178 |
| 101 | MAP3K6 | 0.36122846 |
| 102 | VRK1 | 0.35322680 |
| 103 | MAP2K7 | 0.35038141 |
| 104 | IGF1R | 0.32857481 |
| 105 | MAP3K1 | 0.31531189 |
| 106 | MAPK11 | 0.29447185 |
| 107 | PAK6 | 0.28517182 |
| 108 | PDGFRB | 0.28473322 |
| 109 | RPS6KA1 | 0.28362260 |
| 110 | CSNK1G1 | 0.28318982 |
| 111 | PDK1 | 0.28030598 |
| 112 | FGFR1 | 0.27785857 |
| 113 | RPS6KA5 | 0.27094216 |
| 114 | MAPK12 | 0.26504588 |
| 115 | GRK7 | 0.25564957 |
| 116 | ALK | 0.24741634 |
| 117 | ERN1 | 0.24381426 |
| 118 | NTRK2 | 0.24066738 |
| 119 | PAK4 | 0.23975577 |
| 120 | RET | 0.23869706 |
| 121 | TAOK2 | 0.23752316 |
| 122 | TRPM7 | 0.23528067 |
| 123 | RPS6KA4 | 0.23220539 |
| 124 | CSNK1A1L | 0.22524431 |
| 125 | PIM1 | 0.22050287 |
| 126 | CSNK1G3 | 0.19464204 |
| 127 | ABL1 | 0.19455535 |
| 128 | PIK3CG | 0.19167906 |
| 129 | TGFBR1 | 0.19079983 |
| 130 | MAPK4 | 0.18225741 |
| 131 | HIPK2 | 0.17738721 |
| 132 | TNIK | 0.15932472 |
| 133 | MUSK | 0.14582307 |
| 134 | EPHA3 | 0.14568488 |
| 135 | CDK12 | 0.14357488 |
| 136 | PRKCD | 0.14327402 |
| 137 | MST4 | 0.12346547 |
| 138 | SRC | 0.12090424 |
| 139 | TESK1 | 0.11545152 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.17234725 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.47107160 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.27949071 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 4.19645568 |
| 5 | Antigen processing and presentation_Homo sapiens_hsa04612 | 3.86961047 |
| 6 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.86319584 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 3.08320325 |
| 8 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.06770439 |
| 9 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.69717830 |
| 10 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.66847190 |
| 11 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.37322814 |
| 12 | Measles_Homo sapiens_hsa05162 | 2.12025996 |
| 13 | Viral myocarditis_Homo sapiens_hsa05416 | 2.11226904 |
| 14 | Asthma_Homo sapiens_hsa05310 | 1.85148589 |
| 15 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.77014759 |
| 16 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.73992462 |
| 17 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.69605290 |
| 18 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.63551966 |
| 19 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.58807888 |
| 20 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.55727185 |
| 21 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.27217135 |
| 22 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.23471247 |
| 23 | Hepatitis B_Homo sapiens_hsa05161 | 1.22119250 |
| 24 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.19962883 |
| 25 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.17840893 |
| 26 | Leishmaniasis_Homo sapiens_hsa05140 | 1.15089984 |
| 27 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.12420343 |
| 28 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.09280144 |
| 29 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.05879582 |
| 30 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.02056959 |
| 31 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.98759781 |
| 32 | RNA polymerase_Homo sapiens_hsa03020 | 0.97389200 |
| 33 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.96364901 |
| 34 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.94319176 |
| 35 | Malaria_Homo sapiens_hsa05144 | 0.89919156 |
| 36 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.88514104 |
| 37 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.87471103 |
| 38 | Legionellosis_Homo sapiens_hsa05134 | 0.86125318 |
| 39 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.85402590 |
| 40 | Platelet activation_Homo sapiens_hsa04611 | 0.76669430 |
| 41 | Hepatitis C_Homo sapiens_hsa05160 | 0.74350925 |
| 42 | HTLV-I infection_Homo sapiens_hsa05166 | 0.73608024 |
| 43 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.71432541 |
| 44 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.71194101 |
| 45 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.71123321 |
| 46 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.69345203 |
| 47 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.67366565 |
| 48 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.65870405 |
| 49 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.63959175 |
| 50 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.63176468 |
| 51 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.62806082 |
| 52 | Colorectal cancer_Homo sapiens_hsa05210 | 0.60022256 |
| 53 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.59672762 |
| 54 | Phagosome_Homo sapiens_hsa04145 | 0.59549121 |
| 55 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.54484668 |
| 56 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.54422670 |
| 57 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.50186723 |
| 58 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.49776089 |
| 59 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.49240065 |
| 60 | Spliceosome_Homo sapiens_hsa03040 | 0.49082146 |
| 61 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.47898785 |
| 62 | Influenza A_Homo sapiens_hsa05164 | 0.47731440 |
| 63 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.46233824 |
| 64 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.46061440 |
| 65 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.44184221 |
| 66 | Apoptosis_Homo sapiens_hsa04210 | 0.43973962 |
| 67 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.43744697 |
| 68 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.43697796 |
| 69 | Lysosome_Homo sapiens_hsa04142 | 0.43419136 |
| 70 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.42924016 |
| 71 | Tuberculosis_Homo sapiens_hsa05152 | 0.41634202 |
| 72 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.39920708 |
| 73 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.37149493 |
| 74 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.36666918 |
| 75 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.36524373 |
| 76 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.34290152 |
| 77 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.32300101 |
| 78 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.32260063 |
| 79 | Shigellosis_Homo sapiens_hsa05131 | 0.29295291 |
| 80 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.29072165 |
| 81 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.28826370 |
| 82 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.26298185 |
| 83 | RNA degradation_Homo sapiens_hsa03018 | 0.24979409 |
| 84 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.24223471 |
| 85 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.23364882 |
| 86 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.22235387 |
| 87 | Prion diseases_Homo sapiens_hsa05020 | 0.21655851 |
| 88 | Long-term potentiation_Homo sapiens_hsa04720 | 0.20633690 |
| 89 | Proteasome_Homo sapiens_hsa03050 | 0.19140217 |
| 90 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.19073178 |
| 91 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.18698149 |
| 92 | Prostate cancer_Homo sapiens_hsa05215 | 0.17947492 |
| 93 | Endocytosis_Homo sapiens_hsa04144 | 0.17765520 |
| 94 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.17621807 |
| 95 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.16998006 |
| 96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.16574578 |
| 97 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.15792946 |
| 98 | Pathways in cancer_Homo sapiens_hsa05200 | 0.15571046 |
| 99 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.14628397 |
| 100 | Cocaine addiction_Homo sapiens_hsa05030 | 0.14060741 |
| 101 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.13450333 |
| 102 | Pertussis_Homo sapiens_hsa05133 | 0.13281129 |
| 103 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.12402090 |
| 104 | Salmonella infection_Homo sapiens_hsa05132 | 0.10766696 |
| 105 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.07923329 |
| 106 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.07546566 |
| 107 | Bladder cancer_Homo sapiens_hsa05219 | 0.07167246 |
| 108 | DNA replication_Homo sapiens_hsa03030 | 0.06309998 |
| 109 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.05481094 |
| 110 | Other glycan degradation_Homo sapiens_hsa00511 | 0.05439887 |
| 111 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.05041656 |
| 112 | Endometrial cancer_Homo sapiens_hsa05213 | 0.04496146 |
| 113 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.04363716 |
| 114 | Basal transcription factors_Homo sapiens_hsa03022 | 0.04349499 |
| 115 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.04178255 |
| 116 | Parkinsons disease_Homo sapiens_hsa05012 | 0.03945061 |
| 117 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.02708943 |
| 118 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.01934671 |
| 119 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.01624925 |
| 120 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.00179863 |
| 121 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | -0.0112368 |
| 122 | Glioma_Homo sapiens_hsa05214 | -0.0090214 |
| 123 | Oxidative phosphorylation_Homo sapiens_hsa00190 | -0.0081229 |
| 124 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | -0.0074311 |

