TRAV13-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)9.16071042
2negative T cell selection (GO:0043383)8.95862631
3negative thymic T cell selection (GO:0045060)8.72616217
4positive thymic T cell selection (GO:0045059)7.96042828
5regulation of gamma-delta T cell differentiation (GO:0045586)7.86707810
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.52154307
7positive T cell selection (GO:0043368)7.43627312
8thymic T cell selection (GO:0045061)7.33649619
9regulation of gamma-delta T cell activation (GO:0046643)6.97221477
10T cell selection (GO:0045058)6.73256410
11interferon-gamma production (GO:0032609)6.72974143
12leukocyte aggregation (GO:0070486)6.64051346
13regulation of isotype switching to IgG isotypes (GO:0048302)6.52712999
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.28713081
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.28713081
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.22880124
17T cell receptor signaling pathway (GO:0050852)6.21458516
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.19631796
19T cell costimulation (GO:0031295)5.86303524
20lymphocyte costimulation (GO:0031294)5.85012649
21negative regulation of cell killing (GO:0031342)5.80574574
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.80574574
23sequestering of actin monomers (GO:0042989)5.74435376
24response to interleukin-15 (GO:0070672)5.17470128
25cellular response to interleukin-15 (GO:0071350)5.17254545
26antigen processing and presentation of endogenous antigen (GO:0019883)5.13713975
27regulation of T cell receptor signaling pathway (GO:0050856)4.99529950
28regulation of T cell tolerance induction (GO:0002664)4.95827708
29antigen receptor-mediated signaling pathway (GO:0050851)4.94565757
30regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.90503079
31T cell migration (GO:0072678)4.82365290
32activated T cell proliferation (GO:0050798)4.63425637
33regulation of regulatory T cell differentiation (GO:0045589)4.62306106
34regulation of alpha-beta T cell proliferation (GO:0046640)4.61925086
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.51212720
36antigen processing and presentation via MHC class Ib (GO:0002475)4.46371784
37positive regulation of humoral immune response (GO:0002922)4.43500428
38regulation of interleukin-2 biosynthetic process (GO:0045076)4.41384048
39positive regulation of T cell mediated cytotoxicity (GO:0001916)4.31063954
40positive regulation of alpha-beta T cell proliferation (GO:0046641)4.30273190
41positive regulation of isotype switching (GO:0045830)4.17870496
42mast cell activation (GO:0045576)4.16409770
43regulation of defense response to virus by virus (GO:0050690)4.14483513
44negative regulation of T cell mediated immunity (GO:0002710)4.06662594
45regulation of B cell receptor signaling pathway (GO:0050855)4.06160293
46T cell differentiation (GO:0030217)4.05779756
47natural killer cell differentiation (GO:0001779)4.01445782
48tolerance induction (GO:0002507)3.97802844
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.96722714
50positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.94113847
51positive regulation of natural killer cell mediated immunity (GO:0002717)3.94113847
52positive regulation of tolerance induction (GO:0002645)3.93677625
53regulation of isotype switching (GO:0045191)3.92960770
54positive regulation of interleukin-2 production (GO:0032743)3.84912547
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.80694657
56positive regulation of interleukin-4 production (GO:0032753)3.80287366
57positive regulation of granulocyte differentiation (GO:0030854)3.78190377
58regulation of natural killer cell mediated immunity (GO:0002715)3.77487949
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.77487949
60alpha-beta T cell differentiation (GO:0046632)3.69946326
61positive regulation of uterine smooth muscle contraction (GO:0070474)3.68063233
62positive regulation of B cell mediated immunity (GO:0002714)3.65965039
63positive regulation of immunoglobulin mediated immune response (GO:0002891)3.65965039
64alpha-beta T cell activation (GO:0046631)3.62767750
65positive regulation of DNA recombination (GO:0045911)3.61756369
66regulation of immunoglobulin mediated immune response (GO:0002889)3.61533751
67regulation of immunoglobulin production (GO:0002637)3.60856231
68positive regulation of immunoglobulin production (GO:0002639)3.58105934
69T cell activation (GO:0042110)3.57590229
70regulation of B cell differentiation (GO:0045577)3.56954608
71negative regulation of lymphocyte mediated immunity (GO:0002707)3.55891246
72regulation of response to interferon-gamma (GO:0060330)3.52978528
73positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.52877762
74positive regulation of T cell mediated immunity (GO:0002711)3.49079919
75regulation of B cell mediated immunity (GO:0002712)3.47734777
76regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.45535978
77regulation of leukocyte mediated cytotoxicity (GO:0001910)3.43141793
78regulation of tolerance induction (GO:0002643)3.42516707
79positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.41993784
80regulation of T cell mediated immunity (GO:0002709)3.41261457
81V(D)J recombination (GO:0033151)3.41068475
82positive regulation of growth hormone secretion (GO:0060124)3.40172408
83T cell homeostasis (GO:0043029)3.39801146
84actin nucleation (GO:0045010)3.37998536
85negative regulation of T cell receptor signaling pathway (GO:0050860)3.37603151
86signal complex assembly (GO:0007172)3.35848791
87leukocyte cell-cell adhesion (GO:0007159)3.35012936
88regulation of interleukin-4 production (GO:0032673)3.34471981
89immune response-activating cell surface receptor signaling pathway (GO:0002429)3.32327188
90lymphocyte migration (GO:0072676)3.25488671
91regulation of respiratory burst (GO:0060263)3.25138556
92response to type I interferon (GO:0034340)3.24034926
93positive regulation of lamellipodium assembly (GO:0010592)3.23337389
94positive regulation of T cell activation (GO:0050870)3.22321666
95negative regulation of T cell apoptotic process (GO:0070233)3.18955680
96type I interferon signaling pathway (GO:0060337)3.17906907
97cellular response to type I interferon (GO:0071357)3.17906907
98negative regulation of phagocytosis (GO:0050765)3.17739009
99positive regulation of B cell differentiation (GO:0045579)3.17247846
100regulation of immunoglobulin secretion (GO:0051023)3.16031811
101negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.15868323
102regulation of interleukin-2 production (GO:0032663)3.14112790
103CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13833996
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13057906
105pyrimidine ribonucleoside catabolic process (GO:0046133)3.11356729
106regulation of type I interferon-mediated signaling pathway (GO:0060338)3.11141321
107positive regulation of cell killing (GO:0031343)3.09956122
108mucosal-associated lymphoid tissue development (GO:0048537)3.09416472
109Peyers patch development (GO:0048541)3.09416472
110regulation of chronic inflammatory response (GO:0002676)3.09132461
111T-helper cell differentiation (GO:0042093)3.08484227
112CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.08484227
113regulation of T cell mediated cytotoxicity (GO:0001914)3.08271440
114regulation of interleukin-13 production (GO:0032656)3.07569598
115B cell receptor signaling pathway (GO:0050853)3.06606615
116positive regulation of calcium-mediated signaling (GO:0050850)3.06420456
117respiratory burst (GO:0045730)3.05208357
118lymph node development (GO:0048535)3.04936446
119cellular response to interleukin-4 (GO:0071353)3.03934865
120regulation of alpha-beta T cell activation (GO:0046634)3.03827645
121regulation of cell killing (GO:0031341)3.03696407
122NIK/NF-kappaB signaling (GO:0038061)3.03634046
123cytidine deamination (GO:0009972)3.01269518
124cytidine metabolic process (GO:0046087)3.01269518
125cytidine catabolic process (GO:0006216)3.01269518
126negative regulation of leukocyte mediated immunity (GO:0002704)3.00571717
127regulation of T cell activation (GO:0050863)3.00545893
128positive regulation of lymphocyte mediated immunity (GO:0002708)3.00321734
129regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.00157949
130dendritic cell chemotaxis (GO:0002407)2.97458181
131interferon-gamma-mediated signaling pathway (GO:0060333)2.96131915
132negative regulation of stress fiber assembly (GO:0051497)2.95750895
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.92014720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.72242476
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.18064427
3STAT4_19710469_ChIP-ChIP_TH1__Mouse3.98459745
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.96679550
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.88485933
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.73479957
7RUNX_20019798_ChIP-Seq_JUKART_Human3.69434701
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.63138501
9MYB_26560356_Chip-Seq_TH2_Human3.45045117
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34534410
11MYC_22102868_ChIP-Seq_BL_Human3.30965124
12E2F7_22180533_ChIP-Seq_HELA_Human3.30473207
13MAF_26560356_Chip-Seq_TH1_Human3.15843196
14UTX_26944678_Chip-Seq_JUKART_Human3.07149387
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.78337747
16MYB_26560356_Chip-Seq_TH1_Human2.72520116
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71548325
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.56528085
19MAF_26560356_Chip-Seq_TH2_Human2.38262158
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35980719
21VDR_21846776_ChIP-Seq_THP-1_Human2.29414038
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.24653098
23GATA3_27048872_Chip-Seq_THYMUS_Human2.16276826
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13073812
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06902702
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.06310346
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01137991
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00643748
29SPI1_23547873_ChIP-Seq_NB4_Human1.78899790
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77064928
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75030945
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67730088
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66929710
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.62584269
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61894019
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61067908
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59618638
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59326088
39TCF7_22412390_ChIP-Seq_EML_Mouse1.57428717
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56038712
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54504477
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53981216
43VDR_24763502_ChIP-Seq_THP-1_Human1.53675537
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51305255
45KDM2B_26808549_Chip-Seq_DND41_Human1.49742061
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.47985595
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46834688
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46532475
49FOXP3_21729870_ChIP-Seq_TREG_Human1.46172267
50SCL_19346495_ChIP-Seq_HPC-7_Human1.42806418
51VDR_23849224_ChIP-Seq_CD4+_Human1.40723066
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40419406
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.37781102
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31212777
55SPI1_23127762_ChIP-Seq_K562_Human1.31027177
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31020110
57BCL6_27268052_Chip-Seq_Bcells_Human1.30921066
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27187380
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.23938130
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22294551
61GATA3_26560356_Chip-Seq_TH2_Human1.20867281
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20378676
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20041701
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.14799728
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10570425
66CIITA_25753668_ChIP-Seq_RAJI_Human1.09637144
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07004777
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06452063
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05679072
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.05466810
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04891790
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04810454
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.03843393
74ELK1_19687146_ChIP-ChIP_HELA_Human1.03383369
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03014068
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01674869
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01154913
78GATA1_19941826_ChIP-Seq_K562_Human1.00356387
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00152854
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00105916
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99262242
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98971326
83SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.98895588
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97378706
85ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96860985
86PU_27001747_Chip-Seq_BMDM_Mouse0.95464057
87XRN2_22483619_ChIP-Seq_HELA_Human0.93127515
88GATA3_26560356_Chip-Seq_TH1_Human0.92835024
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92539915
90BCOR_27268052_Chip-Seq_Bcells_Human0.92267263
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90791331
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88211493
93MYC_18940864_ChIP-ChIP_HL60_Human0.87148927
94P300_27268052_Chip-Seq_Bcells_Human0.84721701
95GABP_17652178_ChIP-ChIP_JURKAT_Human0.84613146
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84114838
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82553620
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80269698
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79341661
100SPI1_20517297_ChIP-Seq_HL60_Human0.78534742
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78395649
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77623336
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.77235221
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76844856
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76680572
106EGR1_19032775_ChIP-ChIP_M12_Human0.76569767
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.76498748
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76432509
109VDR_24787735_ChIP-Seq_THP-1_Human0.75846959
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73566122
111TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.73364858
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73124970
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.72762651
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72393001
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.71925031
116RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71836423
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.71713552
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71541437
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70391945
120CTCF_26484167_Chip-Seq_Bcells_Mouse0.70332208
121SA1_27219007_Chip-Seq_Bcells_Human0.69679450
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69318137
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68006412
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67285584
125KDM5A_27292631_Chip-Seq_BREAST_Human0.67081680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.68780050
2MP0005671_abnormal_response_to4.74152670
3MP0000685_abnormal_immune_system4.03200164
4MP0001835_abnormal_antigen_presentation3.14512623
5MP0001800_abnormal_humoral_immune3.13843669
6MP0002166_altered_tumor_susceptibility3.11040416
7MP0006082_CNS_inflammation3.04137338
8MP0002398_abnormal_bone_marrow2.98603281
9MP0002420_abnormal_adaptive_immunity2.97724786
10MP0005387_immune_system_phenotype2.92913486
11MP0001790_abnormal_immune_system2.92913486
12MP0001819_abnormal_immune_cell2.92892111
13MP0000703_abnormal_thymus_morphology2.92742012
14MP0005000_abnormal_immune_tolerance2.91241779
15MP0009333_abnormal_splenocyte_physiolog2.90271281
16MP0002723_abnormal_immune_serum2.71452250
17MP0000716_abnormal_immune_system2.54528057
18MP0003724_increased_susceptibility_to2.52653896
19MP0002396_abnormal_hematopoietic_system2.49930674
20MP0005025_abnormal_response_to2.49903838
21MP0002452_abnormal_antigen_presenting2.48385833
22MP0003436_decreased_susceptibility_to2.47396725
23MP0002933_joint_inflammation2.45510187
24MP0002006_tumorigenesis2.44595601
25MP0009785_altered_susceptibility_to2.42168130
26MP0008057_abnormal_DNA_replication2.39712648
27MP0004947_skin_inflammation2.38578990
28MP0002405_respiratory_system_inflammati2.37922994
29MP0002722_abnormal_immune_system2.37259581
30MP0000689_abnormal_spleen_morphology2.34536505
31MP0004381_abnormal_hair_follicle2.22060105
32MP0003866_abnormal_defecation2.18143596
33MP0002277_abnormal_respiratory_mucosa2.14860283
34MP0002429_abnormal_blood_cell2.04372885
35MP0010155_abnormal_intestine_physiology1.90536177
36MP0002148_abnormal_hypersensitivity_rea1.82747171
37MP0001873_stomach_inflammation1.82261528
38MP0003300_gastrointestinal_ulcer1.79305354
39MP0003303_peritoneal_inflammation1.63916524
40MP0004808_abnormal_hematopoietic_stem1.60751015
41MP0001501_abnormal_sleep_pattern1.59812067
42MP0002419_abnormal_innate_immunity1.59531282
43MP0001348_abnormal_lacrimal_gland1.57508846
44MP0003448_altered_tumor_morphology1.55829846
45MP0001845_abnormal_inflammatory_respons1.50464071
46MP0001851_eye_inflammation1.48194203
47MP0000858_altered_metastatic_potential1.46878527
48MP0005464_abnormal_platelet_physiology1.40174960
49MP0005310_abnormal_salivary_gland1.31022551
50MP0004510_myositis1.29232475
51MP0001533_abnormal_skeleton_physiology1.18022536
52MP0002254_reproductive_system_inflammat1.16817811
53MP0003183_abnormal_peptide_metabolism1.16218759
54MP0001853_heart_inflammation1.15648525
55MP0002102_abnormal_ear_morphology1.13274652
56MP0005075_abnormal_melanosome_morpholog1.10289615
57MP0008469_abnormal_protein_level1.09352503
58MP0000015_abnormal_ear_pigmentation1.08943740
59MP0002909_abnormal_adrenal_gland1.04511027
60MP0002163_abnormal_gland_morphology0.99237011
61MP0000465_gastrointestinal_hemorrhage0.97597842
62MP0002019_abnormal_tumor_incidence0.94146682
63MP0002998_abnormal_bone_remodeling0.93519598
64MP0001545_abnormal_hematopoietic_system0.89114547
65MP0005397_hematopoietic_system_phenotyp0.89114547
66MP0003693_abnormal_embryo_hatching0.86926784
67MP0003172_abnormal_lysosome_physiology0.86801970
68MP0005023_abnormal_wound_healing0.80618408
69MP0002009_preneoplasia0.80127046
70MP0001243_abnormal_dermal_layer0.78422584
71MP0009763_increased_sensitivity_to0.75095206
72MP0008058_abnormal_DNA_repair0.72341225
73MP0003252_abnormal_bile_duct0.72040659
74MP0003279_aneurysm0.70257303
75MP0004883_abnormal_blood_vessel0.70026748
76MP0000604_amyloidosis0.69449401
77MP0000490_abnormal_crypts_of0.67590446
78MP0005166_decreased_susceptibility_to0.67551039
79MP0003959_abnormal_lean_body0.66797393
80MP0005377_hearing/vestibular/ear_phenot0.65812976
81MP0003878_abnormal_ear_physiology0.65812976
82MP0003690_abnormal_glial_cell0.64760612
83MP0003795_abnormal_bone_structure0.64644243
84MP0005379_endocrine/exocrine_gland_phen0.63999948
85MP0001765_abnormal_ion_homeostasis0.63736494
86MP0008260_abnormal_autophagy0.63060439
87MP0001191_abnormal_skin_condition0.62148703
88MP0004130_abnormal_muscle_cell0.62147342
89MP0003077_abnormal_cell_cycle0.59836504
90MP0003828_pulmonary_edema0.59635228
91MP0001919_abnormal_reproductive_system0.59208855
92MP0003786_premature_aging0.57872031
93MP0009643_abnormal_urine_homeostasis0.57469068
94MP0001881_abnormal_mammary_gland0.57300676
95MP0010094_abnormal_chromosome_stability0.56875177
96MP0002132_abnormal_respiratory_system0.55850219
97MP0000609_abnormal_liver_physiology0.55794776
98MP0003045_fibrosis0.55578174
99MP0000372_irregular_coat_pigmentation0.55465137
100MP0008961_abnormal_basal_metabolism0.54325145
101MP0001346_abnormal_lacrimal_gland0.52995143
102MP0002168_other_aberrant_phenotype0.52734267
103MP0005266_abnormal_metabolism0.51065702
104MP0005164_abnormal_response_to0.51008459
105MP0010352_gastrointestinal_tract_polyps0.50984593
106MP0000477_abnormal_intestine_morphology0.50621467
107MP0004957_abnormal_blastocyst_morpholog0.49310976
108MP0009765_abnormal_xenobiotic_induced0.46931631
109MP0003787_abnormal_imprinting0.45668686
110MP0005076_abnormal_cell_differentiation0.43564695
111MP0000249_abnormal_blood_vessel0.43081704
112MP0002136_abnormal_kidney_physiology0.42889497
113MP0000613_abnormal_salivary_gland0.41028646
114MP0002138_abnormal_hepatobiliary_system0.40902488
115MP0003329_amyloid_beta_deposits0.39965719
116MP0008770_decreased_survivor_rate0.39518719
117MP0001216_abnormal_epidermal_layer0.39405281
118MP0005390_skeleton_phenotype0.39238007
119MP0000313_abnormal_cell_death0.38636342
120MP0002693_abnormal_pancreas_physiology0.38023711
121MP0002083_premature_death0.37868085
122MP0008872_abnormal_physiological_respon0.37761687
123MP0009764_decreased_sensitivity_to0.36981198
124MP0001663_abnormal_digestive_system0.36622815
125MP0002822_catalepsy0.36248177
126MP0008877_abnormal_DNA_methylation0.36051804
127MP0000367_abnormal_coat/_hair0.35865937
128MP0000920_abnormal_myelination0.35495330
129MP0003633_abnormal_nervous_system0.34457834

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.21027703
2Abnormality of T cell number (HP:0011839)8.01190306
3Severe combined immunodeficiency (HP:0004430)6.25556357
4Elevated erythrocyte sedimentation rate (HP:0003565)5.86181089
5Combined immunodeficiency (HP:0005387)5.81495307
6Abnormality of T cells (HP:0002843)5.65545877
7Increased IgM level (HP:0003496)5.35783761
8Stomatitis (HP:0010280)5.30671188
9IgG deficiency (HP:0004315)5.23492195
10Recurrent bronchitis (HP:0002837)4.88117966
11Eosinophilia (HP:0001880)4.80554289
12Eczematoid dermatitis (HP:0000976)4.71955455
13Panhypogammaglobulinemia (HP:0003139)4.68146730
14Autoimmune hemolytic anemia (HP:0001890)4.49740697
15Abnormality of eosinophils (HP:0001879)4.43722775
16Chronic otitis media (HP:0000389)4.34136734
17Abnormality of the fingertips (HP:0001211)4.19676300
18IgM deficiency (HP:0002850)4.18989381
19Slow saccadic eye movements (HP:0000514)4.13014920
20Granulocytopenia (HP:0001913)4.12441347
21Recurrent fungal infections (HP:0002841)3.97709672
22Recurrent viral infections (HP:0004429)3.89962252
23Keratoconjunctivitis (HP:0001096)3.81902596
24Leukocytosis (HP:0001974)3.81544684
25Nasal polyposis (HP:0100582)3.68804539
26Joint swelling (HP:0001386)3.68458115
27Chronic diarrhea (HP:0002028)3.64930390
28Recurrent bacterial skin infections (HP:0005406)3.64741928
29Abnormality of B cell number (HP:0010975)3.59167906
30B lymphocytopenia (HP:0010976)3.59167906
31Aplastic anemia (HP:0001915)3.58547628
32Optic neuritis (HP:0100653)3.53172353
33Retrobulbar optic neuritis (HP:0100654)3.53172353
34Abnormality of T cell physiology (HP:0011840)3.42746733
35Lymphopenia (HP:0001888)3.38426724
36Renal cortical cysts (HP:0000803)3.33691463
37Abnormality of cells of the lymphoid lineage (HP:0012140)3.33012641
38Orchitis (HP:0100796)3.28562113
39Severe visual impairment (HP:0001141)3.18304168
40Prostate neoplasm (HP:0100787)3.18111527
41Abnormality of macrophages (HP:0004311)3.17171721
42Recurrent cutaneous fungal infections (HP:0011370)3.11424942
43Chronic mucocutaneous candidiasis (HP:0002728)3.11424942
44Sensory axonal neuropathy (HP:0003390)3.07704536
45Hypoplasia of the thymus (HP:0000778)3.04681548
46Hypergammaglobulinemia (HP:0010702)3.01406700
47Abnormality of the nasal mucosa (HP:0000433)3.01105655
48Myositis (HP:0100614)2.95199092
49Trigonocephaly (HP:0000243)2.91171345
50IgA deficiency (HP:0002720)2.86735319
51Pustule (HP:0200039)2.82116567
52Abnormality of oral frenula (HP:0000190)2.80704518
53Oral leukoplakia (HP:0002745)2.80019539
54Bronchitis (HP:0012387)2.74282156
55Gastrointestinal infarctions (HP:0005244)2.73448197
56Thyroiditis (HP:0100646)2.70096691
57Autoimmune thrombocytopenia (HP:0001973)2.69488436
58Amyotrophic lateral sclerosis (HP:0007354)2.63304595
59Keratitis (HP:0000491)2.56102536
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.53084893
61Lymphoma (HP:0002665)2.49453577
62Recurrent sinusitis (HP:0011108)2.41693561
63Mitral stenosis (HP:0001718)2.35436316
64Vasculitis (HP:0002633)2.32927707
65Basal cell carcinoma (HP:0002671)2.32150830
66Meningitis (HP:0001287)2.30199445
673-Methylglutaconic aciduria (HP:0003535)2.25937751
68Microcytic anemia (HP:0001935)2.25019566
69Palpebral edema (HP:0100540)2.24947527
70Hypochromic microcytic anemia (HP:0004840)2.21796795
71Encephalitis (HP:0002383)2.21366625
72Acute hepatic failure (HP:0006554)2.19996103
73Recurrent otitis media (HP:0000403)2.18942157
74Recurrent gram-negative bacterial infections (HP:0005420)2.17240435
75Hepatitis (HP:0012115)2.16741694
76Hypochromic anemia (HP:0001931)2.16180421
77Recurrent abscess formation (HP:0002722)2.15048039
78Respiratory difficulties (HP:0002880)2.14825089
79Basal ganglia calcification (HP:0002135)2.14176775
80Chronic sinusitis (HP:0011109)2.13705360
81Thrombocytosis (HP:0001894)2.13433113
82Prolonged bleeding time (HP:0003010)2.13372534
83Chronic obstructive pulmonary disease (HP:0006510)2.12593904
84Obstructive lung disease (HP:0006536)2.12593904
85Hemoptysis (HP:0002105)2.07906753
86Gingival bleeding (HP:0000225)2.07183723
87Urticaria (HP:0001025)2.06177974
88Dislocated radial head (HP:0003083)2.06157470
89Abnormal platelet volume (HP:0011876)2.04531906
90Cerebral hypomyelination (HP:0006808)2.04457228
91Petechiae (HP:0000967)2.03638672
92Increased density of long bones (HP:0006392)2.03173896
93Anorexia (HP:0002039)2.00823302
94Mediastinal lymphadenopathy (HP:0100721)2.00078719
95Hypoproteinemia (HP:0003075)1.96195039
96Papilloma (HP:0012740)1.94083615
97Verrucae (HP:0200043)1.94083615
98Pulmonary infiltrates (HP:0002113)1.92930423
99Abnormality of the alveolar ridges (HP:0006477)1.91020354
100Abnormality of the radial head (HP:0003995)1.91009783
101Reduced subcutaneous adipose tissue (HP:0003758)1.90478499
102Glomerulopathy (HP:0100820)1.89829326
103Episodic fever (HP:0001954)1.89694037
104Prominent nose (HP:0000448)1.89612218
105Increased IgE level (HP:0003212)1.89462699
106Exertional dyspnea (HP:0002875)1.88096488
107Recurrent skin infections (HP:0001581)1.87124744
108Hematochezia (HP:0002573)1.86570673
109Hypoalbuminemia (HP:0003073)1.82335481
110Abnormal albumin level (HP:0012116)1.82335481
111Increased hepatocellular lipid droplets (HP:0006565)1.79656134
112Gangrene (HP:0100758)1.78938382
113Increased intramyocellular lipid droplets (HP:0012240)1.78758663
114Wrist flexion contracture (HP:0001239)1.78713278
115Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78396568
116Abnormality of the pleura (HP:0002103)1.77967386
117Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77745500
118Abnormality of the prostate (HP:0008775)1.77669700
119Aplasia/Hypoplasia of the thymus (HP:0010515)1.74097213
120Keratoconjunctivitis sicca (HP:0001097)1.72058738
121Spontaneous hematomas (HP:0007420)1.71890141
122Ureteral stenosis (HP:0000071)1.71034893
123Menstrual irregularities (HP:0000858)1.70878387
124Progressive inability to walk (HP:0002505)1.69765030
125Increased mean platelet volume (HP:0011877)1.69664798
126Epistaxis (HP:0000421)1.66642938
127Chest pain (HP:0100749)1.66497987
128Gastrointestinal inflammation (HP:0004386)1.64216765
129Bronchiectasis (HP:0002110)1.62981259
130Inflammation of the large intestine (HP:0002037)1.60093767
131Skin rash (HP:0000988)1.59900279
132Agammaglobulinemia (HP:0004432)1.59612147
133Arthralgia (HP:0002829)1.58862926
134Pulmonary embolism (HP:0002204)1.57543006
135Hyperacusis (HP:0010780)1.56641044
136Amaurosis fugax (HP:0100576)1.56365692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.89285261
2MAP4K15.06829921
3ZAP703.79956587
4KDR3.26226014
5ITK2.75181546
6MAP3K102.70930897
7CAMKK22.70260448
8JAK32.70029204
9NLK2.57564934
10IKBKE2.57432940
11STK102.44607056
12FGFR42.36449560
13NME22.29529824
14LCK2.20536663
15MST42.20379255
16RIPK42.11312150
17TYK21.97997515
18MAP3K141.97344227
19TAOK31.95964956
20CSK1.93499683
21TBK11.88957609
22MAP3K91.86126749
23MAP3K121.85269564
24TESK21.66434668
25SYK1.62195587
26GRK61.61621870
27HCK1.60772045
28CDC71.53059131
29TESK11.49989202
30TEC1.48467035
31CAMKK11.47590837
32CLK11.46121411
33PRPF4B1.40636746
34MAP3K61.36476637
35PRKCH1.35164458
36BMX1.25905721
37FGFR31.15634474
38PRKCQ1.15104687
39ACVR1B1.14326507
40JAK11.10625960
41BTK1.10460951
42LRRK21.09910145
43VRK21.03293315
44IKBKB0.87388017
45GRK70.86905059
46LYN0.85398247
47SIK30.78676003
48FYN0.76626967
49SCYL20.75705711
50TNK20.75214212
51TYRO30.74380420
52EEF2K0.74000513
53FES0.72912172
54MARK30.71912624
55INSR0.68919075
56DMPK0.66783853
57JAK20.66036722
58BLK0.65402274
59MAP2K60.65006033
60BCKDK0.60038408
61LIMK10.59681300
62CHUK0.58306731
63MYLK0.57559242
64ERN10.57106997
65TAF10.56254073
66SIK20.55297767
67VRK10.54082513
68ADRBK20.54054585
69PDGFRB0.53655244
70ROCK20.53517660
71GRK50.53419267
72IGF1R0.51847726
73STK380.50808531
74SRPK10.50468022
75MAP3K70.50318205
76PDK10.48768335
77RPS6KA40.48678418
78MAPKAPK20.47653464
79TGFBR20.47570613
80KIT0.47380287
81MAP3K40.45136093
82PIK3CG0.44839858
83MAPKAPK30.44672706
84ILK0.44405259
85NUAK10.42872043
86SMG10.42757307
87MAP3K30.42094658
88MARK20.41790591
89ALK0.41283379
90PASK0.41271619
91IRAK40.41052947
92PIM10.40547892
93PLK40.39950194
94PDK40.39232995
95PDK30.39232995
96FGR0.37771946
97TAOK20.37110131
98PKN20.36885998
99TGFBR10.36708045
100NEK60.36435329
101MAP2K20.36171525
102EPHA30.35854790
103MAP3K110.35052217
104CDK40.34618817
105DAPK10.33906344
106FGFR10.33894279
107MELK0.33262059
108NTRK20.31208111
109MAP3K130.30254228
110PRKD20.30029287
111SRC0.29176492
112TTN0.28433212
113EIF2AK20.27562681
114MAP3K50.27073339
115EPHB10.26592034
116CDK120.24879100
117ABL10.22682105
118SIK10.22218477
119MAPK70.21837492
120CDK190.21786489
121CSF1R0.21206718
122MAPK30.20816806
123STK240.20487978
124MAP2K30.19784578
125RPS6KA50.19522447
126TAOK10.18972024
127PRKCD0.18647527
128TLK10.17175796
129MAPK40.16478405
130STK40.16329877
131EGFR0.16120565
132MAPK110.15213930
133PRKCB0.14913079
134HIPK20.13981400
135MAP3K80.12717122
136TSSK60.12481777

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.49407854
2T cell receptor signaling pathway_Homo sapiens_hsa046604.51746973
3Graft-versus-host disease_Homo sapiens_hsa053324.35997453
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.93782558
5Allograft rejection_Homo sapiens_hsa053303.65156487
6Antigen processing and presentation_Homo sapiens_hsa046123.09946504
7Autoimmune thyroid disease_Homo sapiens_hsa053202.97954090
8Measles_Homo sapiens_hsa051622.80906696
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.44940656
10Viral myocarditis_Homo sapiens_hsa054162.44435677
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.42683045
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31265075
13Hematopoietic cell lineage_Homo sapiens_hsa046401.93723204
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78518339
15Type I diabetes mellitus_Homo sapiens_hsa049401.74831872
16Leishmaniasis_Homo sapiens_hsa051401.57819494
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57616469
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52548305
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51651116
20Osteoclast differentiation_Homo sapiens_hsa043801.47841080
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.43661218
22Herpes simplex infection_Homo sapiens_hsa051681.35885946
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.31033304
24Ribosome_Homo sapiens_hsa030101.30626853
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25907156
26Hepatitis B_Homo sapiens_hsa051611.20950311
27B cell receptor signaling pathway_Homo sapiens_hsa046621.18934496
28Asthma_Homo sapiens_hsa053101.13900273
29HTLV-I infection_Homo sapiens_hsa051661.11404072
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.09043125
31Shigellosis_Homo sapiens_hsa051311.06087513
32DNA replication_Homo sapiens_hsa030301.05642209
33Legionellosis_Homo sapiens_hsa051341.04572259
34Colorectal cancer_Homo sapiens_hsa052101.01641969
35Acute myeloid leukemia_Homo sapiens_hsa052210.98437030
36Caffeine metabolism_Homo sapiens_hsa002320.98145324
37Mismatch repair_Homo sapiens_hsa034300.93810669
38Toxoplasmosis_Homo sapiens_hsa051450.91755249
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85485497
40Non-homologous end-joining_Homo sapiens_hsa034500.85476757
41Regulation of autophagy_Homo sapiens_hsa041400.84803057
42Chemokine signaling pathway_Homo sapiens_hsa040620.83488587
43Apoptosis_Homo sapiens_hsa042100.83230098
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80720932
45Spliceosome_Homo sapiens_hsa030400.80355631
46Pancreatic cancer_Homo sapiens_hsa052120.79707642
47Viral carcinogenesis_Homo sapiens_hsa052030.77336511
48Influenza A_Homo sapiens_hsa051640.76523195
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73897697
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73309290
51TNF signaling pathway_Homo sapiens_hsa046680.70888148
52Collecting duct acid secretion_Homo sapiens_hsa049660.70695415
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70217570
54Hepatitis C_Homo sapiens_hsa051600.69420367
55Proteasome_Homo sapiens_hsa030500.68196558
56Staphylococcus aureus infection_Homo sapiens_hsa051500.67118315
57Platelet activation_Homo sapiens_hsa046110.67020364
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66861522
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66342432
60Malaria_Homo sapiens_hsa051440.64253262
61Nucleotide excision repair_Homo sapiens_hsa034200.62269344
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60952683
63Salmonella infection_Homo sapiens_hsa051320.59312154
64Epstein-Barr virus infection_Homo sapiens_hsa051690.54292690
65RNA degradation_Homo sapiens_hsa030180.54183728
66African trypanosomiasis_Homo sapiens_hsa051430.53620179
67VEGF signaling pathway_Homo sapiens_hsa043700.50852779
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50639689
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50399117
70p53 signaling pathway_Homo sapiens_hsa041150.48819305
71Thyroid cancer_Homo sapiens_hsa052160.48729203
72FoxO signaling pathway_Homo sapiens_hsa040680.47340781
73Phagosome_Homo sapiens_hsa041450.46694649
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46519029
75Chronic myeloid leukemia_Homo sapiens_hsa052200.45753679
76Prolactin signaling pathway_Homo sapiens_hsa049170.45309317
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43181978
78Circadian rhythm_Homo sapiens_hsa047100.41352485
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.41303716
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40879203
81Pertussis_Homo sapiens_hsa051330.40074509
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38979264
83Tuberculosis_Homo sapiens_hsa051520.38052981
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.36428132
85Oxidative phosphorylation_Homo sapiens_hsa001900.32545719
86RNA polymerase_Homo sapiens_hsa030200.32267604
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31669327
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29461011
89RNA transport_Homo sapiens_hsa030130.28221086
90Sulfur metabolism_Homo sapiens_hsa009200.27751857
91Rap1 signaling pathway_Homo sapiens_hsa040150.26985538
92Basal transcription factors_Homo sapiens_hsa030220.26710139
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23917333
94Pyrimidine metabolism_Homo sapiens_hsa002400.22418860
95Rheumatoid arthritis_Homo sapiens_hsa053230.21877263
96mRNA surveillance pathway_Homo sapiens_hsa030150.19725746
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17981017
98Prostate cancer_Homo sapiens_hsa052150.17852319
99Base excision repair_Homo sapiens_hsa034100.16790802
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15967847
101Endocytosis_Homo sapiens_hsa041440.15256121
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15193594
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.14729737
104Small cell lung cancer_Homo sapiens_hsa052220.14728857
105Cell cycle_Homo sapiens_hsa041100.14428251
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13637272
107Insulin resistance_Homo sapiens_hsa049310.13277944
108Ras signaling pathway_Homo sapiens_hsa040140.13145634
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11181974
110Inositol phosphate metabolism_Homo sapiens_hsa005620.10914057
111Sulfur relay system_Homo sapiens_hsa041220.10879717
112One carbon pool by folate_Homo sapiens_hsa006700.10705807
113MAPK signaling pathway_Homo sapiens_hsa040100.09917484
114Dorso-ventral axis formation_Homo sapiens_hsa043200.09793298
115Selenocompound metabolism_Homo sapiens_hsa004500.09587634
116Notch signaling pathway_Homo sapiens_hsa043300.09511966
117Adherens junction_Homo sapiens_hsa045200.08668031
118Non-small cell lung cancer_Homo sapiens_hsa052230.08639534
119Chemical carcinogenesis_Homo sapiens_hsa052040.08539504
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07895930
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.07348422
122Endometrial cancer_Homo sapiens_hsa052130.06820222
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05996013

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