

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 9.12530319 |
| 2 | cytidine metabolic process (GO:0046087) | 8.37861602 |
| 3 | cytidine catabolic process (GO:0006216) | 8.37861602 |
| 4 | cytidine deamination (GO:0009972) | 8.37861602 |
| 5 | negative thymic T cell selection (GO:0045060) | 8.36522363 |
| 6 | positive regulation of gamma-delta T cell activation (GO:0046645) | 8.30279047 |
| 7 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 7.77108975 |
| 8 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 7.71714678 |
| 9 | positive T cell selection (GO:0043368) | 7.56979076 |
| 10 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 7.55928110 |
| 11 | DNA deamination (GO:0045006) | 7.33637325 |
| 12 | regulation of gamma-delta T cell differentiation (GO:0045586) | 7.14422169 |
| 13 | T cell selection (GO:0045058) | 7.02971011 |
| 14 | positive thymic T cell selection (GO:0045059) | 6.97108748 |
| 15 | thymic T cell selection (GO:0045061) | 6.95601055 |
| 16 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.88498588 |
| 17 | positive regulation of interleukin-8 secretion (GO:2000484) | 6.85387227 |
| 18 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.66654308 |
| 19 | regulation of gamma-delta T cell activation (GO:0046643) | 6.53768136 |
| 20 | positive regulation of monocyte chemotaxis (GO:0090026) | 6.42494502 |
| 21 | regulation of T cell tolerance induction (GO:0002664) | 6.29310182 |
| 22 | T cell receptor signaling pathway (GO:0050852) | 6.17804988 |
| 23 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.16426196 |
| 24 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.16426196 |
| 25 | response to interleukin-15 (GO:0070672) | 6.15480313 |
| 26 | regulation of lymphocyte chemotaxis (GO:1901623) | 6.11111453 |
| 27 | negative regulation of cell killing (GO:0031342) | 6.02471790 |
| 28 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.02471790 |
| 29 | cellular response to interleukin-15 (GO:0071350) | 6.01218272 |
| 30 | interferon-gamma production (GO:0032609) | 5.89632164 |
| 31 | lymphocyte chemotaxis (GO:0048247) | 5.77137487 |
| 32 | chemokine-mediated signaling pathway (GO:0070098) | 5.74332632 |
| 33 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 5.56224901 |
| 34 | T cell costimulation (GO:0031295) | 5.52797179 |
| 35 | lymphocyte costimulation (GO:0031294) | 5.50398317 |
| 36 | regulation of T cell chemotaxis (GO:0010819) | 5.46117488 |
| 37 | positive regulation of T cell chemotaxis (GO:0010820) | 5.46117488 |
| 38 | positive regulation of lymphocyte migration (GO:2000403) | 5.29555995 |
| 39 | leukocyte aggregation (GO:0070486) | 5.25777092 |
| 40 | activated T cell proliferation (GO:0050798) | 5.21463221 |
| 41 | positive regulation of interleukin-2 production (GO:0032743) | 5.18400026 |
| 42 | positive regulation of tolerance induction (GO:0002645) | 5.15425347 |
| 43 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.09335292 |
| 44 | antigen receptor-mediated signaling pathway (GO:0050851) | 5.00220159 |
| 45 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.94590366 |
| 46 | viral genome replication (GO:0019079) | 4.91626696 |
| 47 | T cell migration (GO:0072678) | 4.90727943 |
| 48 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.86054000 |
| 49 | eosinophil chemotaxis (GO:0048245) | 4.79079926 |
| 50 | negative regulation by host of viral transcription (GO:0043922) | 4.76615470 |
| 51 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.71287480 |
| 52 | dendritic cell chemotaxis (GO:0002407) | 4.68205663 |
| 53 | regulation of interleukin-8 secretion (GO:2000482) | 4.58157971 |
| 54 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.56177567 |
| 55 | regulation of tolerance induction (GO:0002643) | 4.49623892 |
| 56 | regulation of regulatory T cell differentiation (GO:0045589) | 4.49268808 |
| 57 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.40905258 |
| 58 | regulation of activation of Janus kinase activity (GO:0010533) | 4.39383976 |
| 59 | positive regulation of isotype switching (GO:0045830) | 4.37577032 |
| 60 | regulation of lymphocyte migration (GO:2000401) | 4.37516768 |
| 61 | regulation of monocyte chemotaxis (GO:0090025) | 4.35946226 |
| 62 | eosinophil migration (GO:0072677) | 4.30325799 |
| 63 | negative regulation of execution phase of apoptosis (GO:1900118) | 4.28223549 |
| 64 | lymphocyte migration (GO:0072676) | 4.22006569 |
| 65 | positive regulation of defense response to virus by host (GO:0002230) | 4.18624310 |
| 66 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.15553872 |
| 67 | positive regulation of T cell migration (GO:2000406) | 4.15095320 |
| 68 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.13474723 |
| 69 | V(D)J recombination (GO:0033151) | 4.09523218 |
| 70 | regulation of T cell migration (GO:2000404) | 4.08397817 |
| 71 | regulation of isotype switching (GO:0045191) | 4.07181630 |
| 72 | mast cell activation (GO:0045576) | 4.03755118 |
| 73 | tolerance induction (GO:0002507) | 3.98708240 |
| 74 | T cell differentiation (GO:0030217) | 3.97225464 |
| 75 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.96022228 |
| 76 | dendritic cell migration (GO:0036336) | 3.93792873 |
| 77 | regulation of interleukin-2 production (GO:0032663) | 3.88959462 |
| 78 | regulation of chronic inflammatory response (GO:0002676) | 3.86967595 |
| 79 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.85721904 |
| 80 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.85721904 |
| 81 | macrophage chemotaxis (GO:0048246) | 3.83492091 |
| 82 | alpha-beta T cell differentiation (GO:0046632) | 3.82361832 |
| 83 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.81981261 |
| 84 | positive regulation of B cell mediated immunity (GO:0002714) | 3.81981261 |
| 85 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.81399863 |
| 86 | negative regulation of T cell mediated immunity (GO:0002710) | 3.80560349 |
| 87 | positive regulation of humoral immune response (GO:0002922) | 3.79525801 |
| 88 | negative regulation of type 2 immune response (GO:0002829) | 3.79338734 |
| 89 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.77453902 |
| 90 | positive regulation of DNA recombination (GO:0045911) | 3.72694184 |
| 91 | alpha-beta T cell activation (GO:0046631) | 3.72207243 |
| 92 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.72100948 |
| 93 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.72100948 |
| 94 | positive regulation of interleukin-4 production (GO:0032753) | 3.66599853 |
| 95 | regulation of B cell mediated immunity (GO:0002712) | 3.63875484 |
| 96 | positive regulation of T cell cytokine production (GO:0002726) | 3.62470147 |
| 97 | lymph node development (GO:0048535) | 3.62340651 |
| 98 | T cell activation (GO:0042110) | 3.58777622 |
| 99 | ncRNA 3-end processing (GO:0043628) | 3.58292304 |
| 100 | negative regulation of T cell apoptotic process (GO:0070233) | 3.57761854 |
| 101 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.57624243 |
| 102 | regulation of defense response to virus by virus (GO:0050690) | 3.55645875 |
| 103 | T cell homeostasis (GO:0043029) | 3.54840119 |
| 104 | regulation of immunoglobulin production (GO:0002637) | 3.51741876 |
| 105 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.50697252 |
| 106 | positive regulation of immunoglobulin production (GO:0002639) | 3.45972494 |
| 107 | adaptation of signaling pathway (GO:0023058) | 3.45448771 |
| 108 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.40007585 |
| 109 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.39793491 |
| 110 | regulation of interleukin-4 production (GO:0032673) | 3.38434415 |
| 111 | myeloid dendritic cell activation (GO:0001773) | 3.36429359 |
| 112 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.34390660 |
| 113 | negative regulation of viral genome replication (GO:0045071) | 3.34221762 |
| 114 | regulation of response to interferon-gamma (GO:0060330) | 3.31899699 |
| 115 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.29189504 |
| 116 | cellular response to interleukin-4 (GO:0071353) | 3.28580112 |
| 117 | positive regulation of T cell activation (GO:0050870) | 3.25765249 |
| 118 | leukocyte cell-cell adhesion (GO:0007159) | 3.25660659 |
| 119 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.25202185 |
| 120 | positive regulation of translational initiation (GO:0045948) | 3.24801916 |
| 121 | actin nucleation (GO:0045010) | 3.22945817 |
| 122 | ribosomal small subunit assembly (GO:0000028) | 3.22538605 |
| 123 | cellular defense response (GO:0006968) | 3.13902018 |
| 124 | regulation of cell killing (GO:0031341) | 3.12479183 |
| 125 | positive regulation of T-helper 1 type immune response (GO:0002827) | 3.11209339 |
| 126 | lymphocyte homeostasis (GO:0002260) | 3.11106407 |
| 127 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.10972927 |
| 128 | defense response to protozoan (GO:0042832) | 3.10342309 |
| 129 | regulation of B cell differentiation (GO:0045577) | 3.09983941 |
| 130 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.08867489 |
| 131 | regulation of calcium-mediated signaling (GO:0050848) | 3.08767808 |
| 132 | mast cell activation involved in immune response (GO:0002279) | 3.05568627 |
| 133 | mast cell degranulation (GO:0043303) | 3.05568627 |
| 134 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.04743786 |
| 135 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.03493119 |
| 136 | regulation of T cell activation (GO:0050863) | 3.02664088 |
| 137 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.02306248 |
| 138 | natural killer cell activation (GO:0030101) | 3.02093630 |
| 139 | T cell proliferation (GO:0042098) | 3.01336841 |
| 140 | T cell lineage commitment (GO:0002360) | 3.01058221 |
| 141 | positive regulation of granulocyte differentiation (GO:0030854) | 3.00891474 |
| 142 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.98936423 |
| 143 | regulation of cellular extravasation (GO:0002691) | 2.98300684 |
| 144 | negative regulation of viral transcription (GO:0032897) | 2.98135261 |
| 145 | response to interleukin-4 (GO:0070670) | 2.97571108 |
| 146 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.97297317 |
| 147 | regulation of lymphocyte mediated immunity (GO:0002706) | 2.97080997 |
| 148 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.94224566 |
| 149 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.92948238 |
| 150 | negative regulation of bone resorption (GO:0045779) | 2.92055726 |
| 151 | B cell receptor signaling pathway (GO:0050853) | 2.91906508 |
| 152 | regulation of thymocyte apoptotic process (GO:0070243) | 2.90912906 |
| 153 | positive regulation of cell killing (GO:0031343) | 2.90373984 |
| 154 | myeloid dendritic cell differentiation (GO:0043011) | 2.90253820 |
| 155 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.90152950 |
| 156 | signal complex assembly (GO:0007172) | 2.89602227 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.17594398 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.33798041 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.93351171 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.05532481 |
| 5 | MYC_22102868_ChIP-Seq_BL_Human | 3.99316073 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.96063105 |
| 7 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.70714704 |
| 8 | GATA1_22025678_ChIP-Seq_K562_Human | 3.68855564 |
| 9 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.63414096 |
| 10 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.56824427 |
| 11 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.43295021 |
| 12 | MYB_26560356_Chip-Seq_TH2_Human | 3.34397995 |
| 13 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.15537372 |
| 14 | MAF_26560356_Chip-Seq_TH1_Human | 2.99893022 |
| 15 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.87900304 |
| 16 | UTX_26944678_Chip-Seq_JUKART_Human | 2.86261097 |
| 17 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.83540076 |
| 18 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.70737486 |
| 19 | MYB_26560356_Chip-Seq_TH1_Human | 2.67859565 |
| 20 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.57587566 |
| 21 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.44731734 |
| 22 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.40228766 |
| 23 | MAF_26560356_Chip-Seq_TH2_Human | 2.26031957 |
| 24 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.23360099 |
| 25 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.18063143 |
| 26 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.15558353 |
| 27 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.14198121 |
| 28 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.12172881 |
| 29 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.01183229 |
| 30 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.98173935 |
| 31 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.80662269 |
| 32 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.78160635 |
| 33 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.78084052 |
| 34 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.75311848 |
| 35 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.74222304 |
| 36 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.72888180 |
| 37 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.72779561 |
| 38 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.70290767 |
| 39 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.68298062 |
| 40 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.67992578 |
| 41 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.67259853 |
| 42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67024004 |
| 43 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.64418406 |
| 44 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63850109 |
| 45 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.59707330 |
| 46 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.56353446 |
| 47 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.56082059 |
| 48 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.54579061 |
| 49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53484113 |
| 50 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.48907344 |
| 51 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.48286465 |
| 52 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.45407441 |
| 53 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.45399643 |
| 54 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.43627544 |
| 55 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.42237982 |
| 56 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28111380 |
| 57 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.27675516 |
| 58 | SPI1_23127762_ChIP-Seq_K562_Human | 1.27601983 |
| 59 | GATA3_26560356_Chip-Seq_TH2_Human | 1.26858372 |
| 60 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25729306 |
| 61 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.22509341 |
| 62 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.21866561 |
| 63 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.21547133 |
| 64 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.17031736 |
| 65 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.16668786 |
| 66 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.15676570 |
| 67 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.13580766 |
| 68 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.12862588 |
| 69 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.12681896 |
| 70 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.12547261 |
| 71 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.11489002 |
| 72 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.11040387 |
| 73 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.10208344 |
| 74 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.08673416 |
| 75 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.07336172 |
| 76 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.07127448 |
| 77 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.05343914 |
| 78 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.03920108 |
| 79 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.03833244 |
| 80 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.03153534 |
| 81 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.02665277 |
| 82 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.01375606 |
| 83 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.01264675 |
| 84 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.99746569 |
| 85 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97363811 |
| 86 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.97229934 |
| 87 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.96549498 |
| 88 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.96393109 |
| 89 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.96381120 |
| 90 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.95719846 |
| 91 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.95570171 |
| 92 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.93752704 |
| 93 | GATA3_26560356_Chip-Seq_TH1_Human | 0.92586947 |
| 94 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.90594820 |
| 95 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.90386957 |
| 96 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.88820075 |
| 97 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88482388 |
| 98 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87761276 |
| 99 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.86591554 |
| 100 | P300_27268052_Chip-Seq_Bcells_Human | 0.86345213 |
| 101 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.84116299 |
| 102 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.83647651 |
| 103 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.83333184 |
| 104 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.82699783 |
| 105 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.82252582 |
| 106 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.82208061 |
| 107 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.82157767 |
| 108 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.79332909 |
| 109 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.77608981 |
| 110 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.77356052 |
| 111 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.76521023 |
| 112 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.75087237 |
| 113 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.73885396 |
| 114 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.73299711 |
| 115 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.73048216 |
| 116 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.73016433 |
| 117 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.72664348 |
| 118 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.72336461 |
| 119 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.72281938 |
| 120 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.72228841 |
| 121 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.71686465 |
| 122 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.71502062 |
| 123 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.70524037 |
| 124 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.69740012 |
| 125 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.69507650 |
| 126 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.69186356 |
| 127 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.68923747 |
| 128 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.68352122 |
| 129 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.66798403 |
| 130 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.64794949 |
| 131 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.64656161 |
| 132 | FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.64077014 |
| 133 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.63772071 |
| 134 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.63181718 |
| 135 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.62965654 |
| 136 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.62770486 |
| 137 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 0.62734092 |
| 138 | FLI1_21867929_ChIP-Seq_CD8_Mouse | 0.62636247 |
| 139 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.62089456 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.53191339 |
| 2 | MP0005671_abnormal_response_to | 4.61822437 |
| 3 | MP0000685_abnormal_immune_system | 3.66115012 |
| 4 | MP0003300_gastrointestinal_ulcer | 3.43654422 |
| 5 | MP0002166_altered_tumor_susceptibility | 3.26032407 |
| 6 | MP0000703_abnormal_thymus_morphology | 3.25853162 |
| 7 | MP0009333_abnormal_splenocyte_physiolog | 3.14303512 |
| 8 | MP0002398_abnormal_bone_marrow | 3.02040048 |
| 9 | MP0001800_abnormal_humoral_immune | 3.00710166 |
| 10 | MP0001835_abnormal_antigen_presentation | 2.94611456 |
| 11 | MP0005000_abnormal_immune_tolerance | 2.84068216 |
| 12 | MP0002420_abnormal_adaptive_immunity | 2.80618414 |
| 13 | MP0001819_abnormal_immune_cell | 2.75505377 |
| 14 | MP0001790_abnormal_immune_system | 2.74824400 |
| 15 | MP0005387_immune_system_phenotype | 2.74824400 |
| 16 | MP0002723_abnormal_immune_serum | 2.67133379 |
| 17 | MP0006082_CNS_inflammation | 2.64423692 |
| 18 | MP0002006_tumorigenesis | 2.60085871 |
| 19 | MP0003866_abnormal_defecation | 2.57684469 |
| 20 | MP0002405_respiratory_system_inflammati | 2.57641638 |
| 21 | MP0002396_abnormal_hematopoietic_system | 2.53648327 |
| 22 | MP0002722_abnormal_immune_system | 2.52382763 |
| 23 | MP0000716_abnormal_immune_system | 2.51985318 |
| 24 | MP0009785_altered_susceptibility_to | 2.42774793 |
| 25 | MP0002452_abnormal_antigen_presenting | 2.35758459 |
| 26 | MP0000689_abnormal_spleen_morphology | 2.31413094 |
| 27 | MP0003436_decreased_susceptibility_to | 2.26400345 |
| 28 | MP0010155_abnormal_intestine_physiology | 2.26131396 |
| 29 | MP0005025_abnormal_response_to | 2.21353499 |
| 30 | MP0004947_skin_inflammation | 2.12731514 |
| 31 | MP0003724_increased_susceptibility_to | 2.10405673 |
| 32 | MP0002933_joint_inflammation | 2.07178550 |
| 33 | MP0001873_stomach_inflammation | 2.06700518 |
| 34 | MP0002429_abnormal_blood_cell | 2.04629371 |
| 35 | MP0003329_amyloid_beta_deposits | 1.90866036 |
| 36 | MP0005166_decreased_susceptibility_to | 1.90451942 |
| 37 | MP0003303_peritoneal_inflammation | 1.71876252 |
| 38 | MP0002148_abnormal_hypersensitivity_rea | 1.71570118 |
| 39 | MP0004808_abnormal_hematopoietic_stem | 1.63848663 |
| 40 | MP0001845_abnormal_inflammatory_respons | 1.63731956 |
| 41 | MP0002419_abnormal_innate_immunity | 1.57145533 |
| 42 | MP0004381_abnormal_hair_follicle | 1.55522597 |
| 43 | MP0005464_abnormal_platelet_physiology | 1.54268274 |
| 44 | MP0004510_myositis | 1.51627162 |
| 45 | MP0001853_heart_inflammation | 1.41884959 |
| 46 | MP0005058_abnormal_lysosome_morphology | 1.38175098 |
| 47 | MP0000858_altered_metastatic_potential | 1.34704975 |
| 48 | MP0002132_abnormal_respiratory_system | 1.34575159 |
| 49 | MP0000465_gastrointestinal_hemorrhage | 1.29035950 |
| 50 | MP0003172_abnormal_lysosome_physiology | 1.24541002 |
| 51 | MP0002693_abnormal_pancreas_physiology | 1.24336834 |
| 52 | MP0002009_preneoplasia | 1.23062442 |
| 53 | MP0000569_abnormal_digit_pigmentation | 1.23029311 |
| 54 | MP0010307_abnormal_tumor_latency | 1.15731684 |
| 55 | MP0000490_abnormal_crypts_of | 1.14284348 |
| 56 | MP0004883_abnormal_blood_vessel | 1.13946297 |
| 57 | MP0002277_abnormal_respiratory_mucosa | 1.12749457 |
| 58 | MP0005310_abnormal_salivary_gland | 1.10688677 |
| 59 | MP0002019_abnormal_tumor_incidence | 1.08657822 |
| 60 | MP0003690_abnormal_glial_cell | 1.06895205 |
| 61 | MP0005075_abnormal_melanosome_morpholog | 1.06780468 |
| 62 | MP0003806_abnormal_nucleotide_metabolis | 1.04308953 |
| 63 | MP0003448_altered_tumor_morphology | 1.03186255 |
| 64 | MP0001545_abnormal_hematopoietic_system | 1.00539137 |
| 65 | MP0005397_hematopoietic_system_phenotyp | 1.00539137 |
| 66 | MP0001851_eye_inflammation | 0.98747254 |
| 67 | MP0003183_abnormal_peptide_metabolism | 0.98119387 |
| 68 | MP0001348_abnormal_lacrimal_gland | 0.96403206 |
| 69 | MP0004145_abnormal_muscle_electrophysio | 0.96318656 |
| 70 | MP0004782_abnormal_surfactant_physiolog | 0.96190513 |
| 71 | MP0004233_abnormal_muscle_weight | 0.95721290 |
| 72 | MP0001542_abnormal_bone_strength | 0.93909874 |
| 73 | MP0010094_abnormal_chromosome_stability | 0.93285688 |
| 74 | MP0008469_abnormal_protein_level | 0.92199090 |
| 75 | MP0001533_abnormal_skeleton_physiology | 0.91808708 |
| 76 | MP0008057_abnormal_DNA_replication | 0.91155967 |
| 77 | MP0002876_abnormal_thyroid_physiology | 0.90083304 |
| 78 | MP0003880_abnormal_central_pattern | 0.87336370 |
| 79 | MP0003077_abnormal_cell_cycle | 0.85944956 |
| 80 | MP0002168_other_aberrant_phenotype | 0.85911839 |
| 81 | MP0002998_abnormal_bone_remodeling | 0.84612165 |
| 82 | MP0010352_gastrointestinal_tract_polyps | 0.83561024 |
| 83 | MP0004957_abnormal_blastocyst_morpholog | 0.80913527 |
| 84 | MP0001984_abnormal_olfaction | 0.80822602 |
| 85 | MP0002163_abnormal_gland_morphology | 0.80004087 |
| 86 | MP0002822_catalepsy | 0.78131532 |
| 87 | MP0010234_abnormal_vibrissa_follicle | 0.77636576 |
| 88 | MP0005083_abnormal_biliary_tract | 0.76214969 |
| 89 | MP0001188_hyperpigmentation | 0.74120948 |
| 90 | MP0002138_abnormal_hepatobiliary_system | 0.73983947 |
| 91 | MP0001666_abnormal_nutrient_absorption | 0.73630879 |
| 92 | MP0009643_abnormal_urine_homeostasis | 0.72357002 |
| 93 | MP0005076_abnormal_cell_differentiation | 0.71474992 |
| 94 | MP0000372_irregular_coat_pigmentation | 0.69441027 |
| 95 | MP0000477_abnormal_intestine_morphology | 0.67514163 |
| 96 | MP0005319_abnormal_enzyme/_coenzyme | 0.66944204 |
| 97 | MP0003646_muscle_fatigue | 0.66471115 |
| 98 | MP0003786_premature_aging | 0.66342547 |
| 99 | MP0009278_abnormal_bone_marrow | 0.66201837 |
| 100 | MP0005023_abnormal_wound_healing | 0.65291087 |
| 101 | MP0002136_abnormal_kidney_physiology | 0.63139117 |
| 102 | MP0009765_abnormal_xenobiotic_induced | 0.63056559 |
| 103 | MP0003795_abnormal_bone_structure | 0.60670304 |
| 104 | MP0009763_increased_sensitivity_to | 0.60481355 |
| 105 | MP0004036_abnormal_muscle_relaxation | 0.60324268 |
| 106 | MP0003111_abnormal_nucleus_morphology | 0.59832279 |
| 107 | MP0001663_abnormal_digestive_system | 0.59183030 |
| 108 | MP0000604_amyloidosis | 0.58345637 |
| 109 | MP0000343_altered_response_to | 0.58339546 |
| 110 | MP0001502_abnormal_circadian_rhythm | 0.57749058 |
| 111 | MP0008961_abnormal_basal_metabolism | 0.57526823 |
| 112 | MP0008569_lethality_at_weaning | 0.57199423 |
| 113 | MP0002877_abnormal_melanocyte_morpholog | 0.55594027 |
| 114 | MP0001243_abnormal_dermal_layer | 0.55412017 |
| 115 | MP0000609_abnormal_liver_physiology | 0.53740965 |
| 116 | MP0008260_abnormal_autophagy | 0.53426281 |
| 117 | MP0000350_abnormal_cell_proliferation | 0.53114260 |
| 118 | MP0003787_abnormal_imprinting | 0.52483616 |
| 119 | MP0003137_abnormal_impulse_conducting | 0.51775840 |
| 120 | MP0008007_abnormal_cellular_replicative | 0.51139331 |
| 121 | MP0003693_abnormal_embryo_hatching | 0.50906959 |
| 122 | MP0005645_abnormal_hypothalamus_physiol | 0.50463236 |
| 123 | MP0005164_abnormal_response_to | 0.50194180 |
| 124 | MP0000920_abnormal_myelination | 0.49867745 |
| 125 | MP0001881_abnormal_mammary_gland | 0.49177711 |
| 126 | MP0001764_abnormal_homeostasis | 0.49103041 |
| 127 | MP0002095_abnormal_skin_pigmentation | 0.48027052 |
| 128 | MP0000313_abnormal_cell_death | 0.47582265 |
| 129 | MP0009764_decreased_sensitivity_to | 0.47511529 |
| 130 | MP0002928_abnormal_bile_duct | 0.46176757 |
| 131 | MP0005084_abnormal_gallbladder_morpholo | 0.45334567 |
| 132 | MP0001191_abnormal_skin_condition | 0.43618874 |
| 133 | MP0005174_abnormal_tail_pigmentation | 0.42641646 |
| 134 | MP0000367_abnormal_coat/_hair | 0.42569025 |
| 135 | MP0002083_premature_death | 0.42055403 |
| 136 | MP0003045_fibrosis | 0.40415089 |
| 137 | MP0008770_decreased_survivor_rate | 0.38196569 |
| 138 | MP0003252_abnormal_bile_duct | 0.38131810 |
| 139 | MP0008873_increased_physiological_sensi | 0.38041438 |
| 140 | MP0008877_abnormal_DNA_methylation | 0.37505502 |
| 141 | MP0006054_spinal_hemorrhage | 0.36799645 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 9.03437580 |
| 2 | Abnormality of T cell number (HP:0011839) | 8.64810995 |
| 3 | Severe combined immunodeficiency (HP:0004430) | 6.68871456 |
| 4 | Combined immunodeficiency (HP:0005387) | 6.30919271 |
| 5 | Abnormality of T cells (HP:0002843) | 5.80782379 |
| 6 | Stomatitis (HP:0010280) | 5.65450585 |
| 7 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.57103925 |
| 8 | Eosinophilia (HP:0001880) | 5.27897339 |
| 9 | Panhypogammaglobulinemia (HP:0003139) | 5.08568431 |
| 10 | IgG deficiency (HP:0004315) | 5.06687983 |
| 11 | Abnormality of eosinophils (HP:0001879) | 4.91188778 |
| 12 | Recurrent viral infections (HP:0004429) | 4.84127903 |
| 13 | B lymphocytopenia (HP:0010976) | 4.71780847 |
| 14 | Abnormality of B cell number (HP:0010975) | 4.71780847 |
| 15 | Recurrent fungal infections (HP:0002841) | 4.66667743 |
| 16 | Increased IgM level (HP:0003496) | 4.53333628 |
| 17 | Hypoplasia of the thymus (HP:0000778) | 4.50918265 |
| 18 | Granulocytopenia (HP:0001913) | 4.45589119 |
| 19 | Recurrent bronchitis (HP:0002837) | 4.42741043 |
| 20 | Nasal polyposis (HP:0100582) | 4.21348036 |
| 21 | Thyroiditis (HP:0100646) | 4.15015449 |
| 22 | Leukocytosis (HP:0001974) | 4.14740966 |
| 23 | Chronic otitis media (HP:0000389) | 4.04319020 |
| 24 | IgM deficiency (HP:0002850) | 3.76405822 |
| 25 | Joint swelling (HP:0001386) | 3.70601753 |
| 26 | Autoimmune hemolytic anemia (HP:0001890) | 3.69396410 |
| 27 | Pustule (HP:0200039) | 3.56867406 |
| 28 | Chronic diarrhea (HP:0002028) | 3.54720247 |
| 29 | Eczematoid dermatitis (HP:0000976) | 3.53241790 |
| 30 | J-shaped sella turcica (HP:0002680) | 3.50658364 |
| 31 | Recurrent cutaneous fungal infections (HP:0011370) | 3.45088880 |
| 32 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.45088880 |
| 33 | Abnormality of the nasal mucosa (HP:0000433) | 3.43435681 |
| 34 | Acute hepatic failure (HP:0006554) | 3.42222847 |
| 35 | Aplastic anemia (HP:0001915) | 3.41452392 |
| 36 | Lymphopenia (HP:0001888) | 3.36573333 |
| 37 | Recurrent bacterial skin infections (HP:0005406) | 3.32216305 |
| 38 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.29696411 |
| 39 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.20543565 |
| 40 | Abnormality of T cell physiology (HP:0011840) | 3.14493152 |
| 41 | Cerebral hypomyelination (HP:0006808) | 3.06292727 |
| 42 | Myositis (HP:0100614) | 3.06136749 |
| 43 | Abnormality of the fingertips (HP:0001211) | 3.03336721 |
| 44 | IgA deficiency (HP:0002720) | 2.91332031 |
| 45 | Gastrointestinal infarctions (HP:0005244) | 2.91050369 |
| 46 | Hemiplegia (HP:0002301) | 2.82698314 |
| 47 | Lymphoma (HP:0002665) | 2.82283717 |
| 48 | Autoimmune thrombocytopenia (HP:0001973) | 2.70835276 |
| 49 | Thrombocytosis (HP:0001894) | 2.65318877 |
| 50 | Hypergammaglobulinemia (HP:0010702) | 2.63987881 |
| 51 | Abnormality of macrophages (HP:0004311) | 2.59946456 |
| 52 | Abnormality of the alveolar ridges (HP:0006477) | 2.57131341 |
| 53 | Meningitis (HP:0001287) | 2.56980371 |
| 54 | Bronchitis (HP:0012387) | 2.51803777 |
| 55 | Encephalitis (HP:0002383) | 2.51396386 |
| 56 | Trigonocephaly (HP:0000243) | 2.50717467 |
| 57 | Basal cell carcinoma (HP:0002671) | 2.47978744 |
| 58 | Hemoptysis (HP:0002105) | 2.47160070 |
| 59 | Volvulus (HP:0002580) | 2.41873618 |
| 60 | Spontaneous hematomas (HP:0007420) | 2.38794348 |
| 61 | Carpal bone hypoplasia (HP:0001498) | 2.38261782 |
| 62 | Gangrene (HP:0100758) | 2.34973989 |
| 63 | Papilloma (HP:0012740) | 2.31097681 |
| 64 | Verrucae (HP:0200043) | 2.31097681 |
| 65 | Palpitations (HP:0001962) | 2.30781378 |
| 66 | Recurrent sinusitis (HP:0011108) | 2.28593058 |
| 67 | CNS hypomyelination (HP:0003429) | 2.26688416 |
| 68 | Amaurosis fugax (HP:0100576) | 2.23478233 |
| 69 | Chest pain (HP:0100749) | 2.23386742 |
| 70 | Obstructive lung disease (HP:0006536) | 2.22639746 |
| 71 | Chronic obstructive pulmonary disease (HP:0006510) | 2.22639746 |
| 72 | Vasculitis (HP:0002633) | 2.22624183 |
| 73 | Alveolar cell carcinoma (HP:0006519) | 2.21454627 |
| 74 | Mediastinal lymphadenopathy (HP:0100721) | 2.20289508 |
| 75 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.18172642 |
| 76 | Premature ovarian failure (HP:0008209) | 2.18010505 |
| 77 | Arterial thrombosis (HP:0004420) | 2.17547399 |
| 78 | Pulmonary infiltrates (HP:0002113) | 2.15878416 |
| 79 | Renal cortical cysts (HP:0000803) | 2.15655837 |
| 80 | Increased IgE level (HP:0003212) | 2.13829601 |
| 81 | Recurrent otitis media (HP:0000403) | 2.13162790 |
| 82 | Optic neuritis (HP:0100653) | 2.12186623 |
| 83 | Retrobulbar optic neuritis (HP:0100654) | 2.12186623 |
| 84 | Epistaxis (HP:0000421) | 2.11722556 |
| 85 | Abnormal tarsal ossification (HP:0008369) | 2.11078511 |
| 86 | Delusions (HP:0000746) | 2.10552849 |
| 87 | Premature graying of hair (HP:0002216) | 2.08767175 |
| 88 | Abnormal platelet volume (HP:0011876) | 2.07104779 |
| 89 | Periodontitis (HP:0000704) | 2.06116708 |
| 90 | Pulmonary embolism (HP:0002204) | 2.03941973 |
| 91 | Abnormality of the prostate (HP:0008775) | 2.03397086 |
| 92 | Ureteral stenosis (HP:0000071) | 2.01881288 |
| 93 | Hypoalbuminemia (HP:0003073) | 1.98752013 |
| 94 | Abnormal albumin level (HP:0012116) | 1.98752013 |
| 95 | Stomach cancer (HP:0012126) | 1.96300152 |
| 96 | Bicuspid aortic valve (HP:0001647) | 1.95762928 |
| 97 | Increased density of long bones (HP:0006392) | 1.91528233 |
| 98 | Chronic sinusitis (HP:0011109) | 1.90420639 |
| 99 | Abnormality of the pleura (HP:0002103) | 1.90382914 |
| 100 | Gingivitis (HP:0000230) | 1.89899147 |
| 101 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.89416531 |
| 102 | Recurrent skin infections (HP:0001581) | 1.89371154 |
| 103 | Abnormal pupillary function (HP:0007686) | 1.89305013 |
| 104 | Increased intramyocellular lipid droplets (HP:0012240) | 1.88626178 |
| 105 | Premature loss of primary teeth (HP:0006323) | 1.86036842 |
| 106 | Inflammation of the large intestine (HP:0002037) | 1.85914547 |
| 107 | Dislocated radial head (HP:0003083) | 1.85848554 |
| 108 | Orchitis (HP:0100796) | 1.84091060 |
| 109 | Prolonged bleeding time (HP:0003010) | 1.83732158 |
| 110 | Gastrointestinal inflammation (HP:0004386) | 1.83659440 |
| 111 | Cellular immunodeficiency (HP:0005374) | 1.82497275 |
| 112 | Recurrent abscess formation (HP:0002722) | 1.82316772 |
| 113 | Broad face (HP:0000283) | 1.80965455 |
| 114 | Gingival bleeding (HP:0000225) | 1.80711034 |
| 115 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.80415122 |
| 116 | Personality changes (HP:0000751) | 1.80351399 |
| 117 | Pulmonary fibrosis (HP:0002206) | 1.79240177 |
| 118 | Ureteral obstruction (HP:0006000) | 1.78725473 |
| 119 | Hypoproteinemia (HP:0003075) | 1.78594607 |
| 120 | Cheilitis (HP:0100825) | 1.78367158 |
| 121 | Skin rash (HP:0000988) | 1.77315347 |
| 122 | Congenital stationary night blindness (HP:0007642) | 1.77026998 |
| 123 | Keratoconjunctivitis sicca (HP:0001097) | 1.75906285 |
| 124 | Abnormal number of erythroid precursors (HP:0012131) | 1.75577712 |
| 125 | Microvesicular hepatic steatosis (HP:0001414) | 1.75443091 |
| 126 | Hepatitis (HP:0012115) | 1.75307527 |
| 127 | Abnormality of the radial head (HP:0003995) | 1.74980260 |
| 128 | Bronchiectasis (HP:0002110) | 1.71362425 |
| 129 | Anorexia (HP:0002039) | 1.71069046 |
| 130 | Poor speech (HP:0002465) | 1.69868387 |
| 131 | Abnormality of oral frenula (HP:0000190) | 1.69299502 |
| 132 | Agammaglobulinemia (HP:0004432) | 1.68582331 |
| 133 | Reticulocytopenia (HP:0001896) | 1.68424248 |
| 134 | Abnormality of the thymus (HP:0000777) | 1.65479737 |
| 135 | Diplopia (HP:0000651) | 1.64349763 |
| 136 | Abnormality of binocular vision (HP:0011514) | 1.64349763 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.95135983 |
| 2 | MAP4K1 | 5.75908450 |
| 3 | EIF2AK3 | 4.73317712 |
| 4 | ZAP70 | 3.42819196 |
| 5 | ITK | 3.42748473 |
| 6 | JAK3 | 2.85564775 |
| 7 | STK10 | 2.78972959 |
| 8 | FGFR4 | 2.53105026 |
| 9 | BCKDK | 2.43881216 |
| 10 | MAPKAPK3 | 2.30623911 |
| 11 | MAP3K10 | 2.30207102 |
| 12 | MAP3K14 | 2.24264900 |
| 13 | TYK2 | 2.13226022 |
| 14 | LCK | 2.05991362 |
| 15 | GRK6 | 2.04021490 |
| 16 | NLK | 2.03236453 |
| 17 | IKBKE | 1.93497496 |
| 18 | LATS1 | 1.77739669 |
| 19 | MAP3K7 | 1.77226401 |
| 20 | TEC | 1.71300058 |
| 21 | IRAK3 | 1.69388846 |
| 22 | MST4 | 1.68099611 |
| 23 | CSK | 1.61536469 |
| 24 | PDK2 | 1.57102673 |
| 25 | FGFR3 | 1.56719311 |
| 26 | SYK | 1.55427412 |
| 27 | JAK1 | 1.53670243 |
| 28 | PRKCQ | 1.52587444 |
| 29 | EEF2K | 1.51664287 |
| 30 | TESK2 | 1.47189064 |
| 31 | PRKCH | 1.46408879 |
| 32 | NME1 | 1.40394472 |
| 33 | PKN2 | 1.36940570 |
| 34 | KDR | 1.33391278 |
| 35 | HCK | 1.30166321 |
| 36 | NME2 | 1.23145677 |
| 37 | LRRK2 | 1.19515120 |
| 38 | GRK7 | 1.18251373 |
| 39 | BTK | 1.16543827 |
| 40 | MAP3K12 | 1.11839775 |
| 41 | IKBKB | 1.10121506 |
| 42 | MAP3K13 | 1.09452732 |
| 43 | TBK1 | 1.03142854 |
| 44 | TNIK | 1.02825660 |
| 45 | ADRBK2 | 0.99048782 |
| 46 | TNK2 | 0.98666693 |
| 47 | PRPF4B | 0.94917348 |
| 48 | DAPK1 | 0.92349187 |
| 49 | TRIB3 | 0.91863793 |
| 50 | PIK3CG | 0.90829088 |
| 51 | FES | 0.87691484 |
| 52 | TAOK2 | 0.87654671 |
| 53 | CLK1 | 0.82787149 |
| 54 | TYRO3 | 0.80055269 |
| 55 | PDGFRB | 0.79614694 |
| 56 | PRKD2 | 0.79481479 |
| 57 | TAOK1 | 0.79053404 |
| 58 | JAK2 | 0.78368410 |
| 59 | PIM1 | 0.77722778 |
| 60 | MAPK7 | 0.77583655 |
| 61 | FGFR1 | 0.75515648 |
| 62 | CDK9 | 0.74114254 |
| 63 | CAMKK2 | 0.73575618 |
| 64 | MARK3 | 0.73106180 |
| 65 | PASK | 0.72786361 |
| 66 | TSSK6 | 0.72458726 |
| 67 | CHUK | 0.69577897 |
| 68 | RIPK4 | 0.69349426 |
| 69 | LYN | 0.69235498 |
| 70 | RAF1 | 0.69088060 |
| 71 | RPS6KA4 | 0.66726392 |
| 72 | MAP2K6 | 0.66191065 |
| 73 | CDK4 | 0.62623869 |
| 74 | BLK | 0.61545756 |
| 75 | KIT | 0.59149398 |
| 76 | CAMKK1 | 0.58576860 |
| 77 | CDC7 | 0.55830452 |
| 78 | SIK3 | 0.55275075 |
| 79 | ZAK | 0.53464984 |
| 80 | INSR | 0.53444036 |
| 81 | CDK12 | 0.53442921 |
| 82 | VRK2 | 0.52425641 |
| 83 | ALK | 0.52010356 |
| 84 | SIK2 | 0.51526143 |
| 85 | PIM2 | 0.51392082 |
| 86 | PRKCD | 0.49827611 |
| 87 | MARK2 | 0.49224654 |
| 88 | FYN | 0.47435072 |
| 89 | TAOK3 | 0.47248167 |
| 90 | MELK | 0.45524386 |
| 91 | MAPK12 | 0.44771944 |
| 92 | TESK1 | 0.44634329 |
| 93 | ABL1 | 0.44555631 |
| 94 | EPHB1 | 0.44472916 |
| 95 | MAP2K3 | 0.43830681 |
| 96 | MYLK | 0.43670754 |
| 97 | EPHA3 | 0.43435479 |
| 98 | PRKCA | 0.43118604 |
| 99 | CDK6 | 0.41691143 |
| 100 | MAPK4 | 0.40591470 |
| 101 | TGFBR2 | 0.39797287 |
| 102 | EIF2AK1 | 0.39554459 |
| 103 | FRK | 0.39386894 |
| 104 | BRD4 | 0.39379787 |
| 105 | SGK223 | 0.39026298 |
| 106 | SGK494 | 0.39026298 |
| 107 | TIE1 | 0.38352272 |
| 108 | MAPKAPK2 | 0.37764895 |
| 109 | NEK6 | 0.37659967 |
| 110 | PRKCB | 0.36936935 |
| 111 | PRKD1 | 0.36776285 |
| 112 | IGF1R | 0.36772628 |
| 113 | MAPK11 | 0.36549000 |
| 114 | MAP3K8 | 0.36520560 |
| 115 | PDK1 | 0.34648025 |
| 116 | HIPK2 | 0.33949840 |
| 117 | CSF1R | 0.32669422 |
| 118 | RPS6KA5 | 0.32044832 |
| 119 | LIMK1 | 0.31122833 |
| 120 | FLT3 | 0.30640362 |
| 121 | TGFBR1 | 0.29787829 |
| 122 | ILK | 0.29650640 |
| 123 | OBSCN | 0.29166440 |
| 124 | MAPK3 | 0.29025098 |
| 125 | EIF2AK2 | 0.28729270 |
| 126 | ROCK2 | 0.28371685 |
| 127 | CAMK2A | 0.27229537 |
| 128 | FGFR2 | 0.27085204 |
| 129 | GRK1 | 0.26607033 |
| 130 | RPS6KA6 | 0.26603627 |
| 131 | IRAK4 | 0.25986018 |
| 132 | STK4 | 0.25499602 |
| 133 | MAP3K11 | 0.24430772 |
| 134 | PTK2B | 0.23370324 |
| 135 | NTRK2 | 0.23296084 |
| 136 | AURKA | 0.22397839 |
| 137 | CHEK1 | 0.22239410 |
| 138 | NUAK1 | 0.20534739 |
| 139 | PRKACA | 0.20160887 |
| 140 | MAPK9 | 0.19339295 |
| 141 | PRKCI | 0.18605125 |
| 142 | PRKCZ | 0.16614264 |
| 143 | CSNK2A1 | 0.15612920 |
| 144 | INSRR | 0.15400026 |
| 145 | VRK1 | 0.14923243 |
| 146 | DYRK2 | 0.14272900 |
| 147 | PIK3CA | 0.13334890 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.31847424 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.68628819 |
| 3 | Measles_Homo sapiens_hsa05162 | 3.05825521 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.88803919 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.79453943 |
| 6 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.75269106 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.72809986 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.71076062 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.62799398 |
| 10 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.46156388 |
| 11 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.36922257 |
| 12 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.30598758 |
| 13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.15798779 |
| 14 | Leishmaniasis_Homo sapiens_hsa05140 | 1.96853268 |
| 15 | Viral myocarditis_Homo sapiens_hsa05416 | 1.90841558 |
| 16 | Ribosome_Homo sapiens_hsa03010 | 1.71205018 |
| 17 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.71127974 |
| 18 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.68003898 |
| 19 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.61749624 |
| 20 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.57703407 |
| 21 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.51980800 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.50383080 |
| 23 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.46181283 |
| 24 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.43151003 |
| 25 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.36034713 |
| 26 | Shigellosis_Homo sapiens_hsa05131 | 1.35941860 |
| 27 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.35284161 |
| 28 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.34787659 |
| 29 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.34777989 |
| 30 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.33677721 |
| 31 | Asthma_Homo sapiens_hsa05310 | 1.31563570 |
| 32 | Hepatitis B_Homo sapiens_hsa05161 | 1.29314803 |
| 33 | HTLV-I infection_Homo sapiens_hsa05166 | 1.27253346 |
| 34 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.24201197 |
| 35 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.19980076 |
| 36 | Spliceosome_Homo sapiens_hsa03040 | 1.19477123 |
| 37 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.18447028 |
| 38 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.18285207 |
| 39 | Colorectal cancer_Homo sapiens_hsa05210 | 1.12787173 |
| 40 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.12361267 |
| 41 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.11846492 |
| 42 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.11720004 |
| 43 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.09990357 |
| 44 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.96838674 |
| 45 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.94857108 |
| 46 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.93697969 |
| 47 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.90092077 |
| 48 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.88770475 |
| 49 | Influenza A_Homo sapiens_hsa05164 | 0.87706032 |
| 50 | DNA replication_Homo sapiens_hsa03030 | 0.87337251 |
| 51 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.86626885 |
| 52 | Apoptosis_Homo sapiens_hsa04210 | 0.85277857 |
| 53 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.84968133 |
| 54 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.84307297 |
| 55 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.84131124 |
| 56 | Prion diseases_Homo sapiens_hsa05020 | 0.73040097 |
| 57 | Hepatitis C_Homo sapiens_hsa05160 | 0.71369622 |
| 58 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.71112080 |
| 59 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.70388113 |
| 60 | Sulfur relay system_Homo sapiens_hsa04122 | 0.69993342 |
| 61 | Platelet activation_Homo sapiens_hsa04611 | 0.68806986 |
| 62 | Parkinsons disease_Homo sapiens_hsa05012 | 0.67599626 |
| 63 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.66696750 |
| 64 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.66444748 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.65607729 |
| 66 | RNA degradation_Homo sapiens_hsa03018 | 0.64538934 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.64102844 |
| 68 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.58343217 |
| 69 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.56896366 |
| 70 | Prostate cancer_Homo sapiens_hsa05215 | 0.56688329 |
| 71 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.55336879 |
| 72 | Purine metabolism_Homo sapiens_hsa00230 | 0.55239186 |
| 73 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.54702468 |
| 74 | Endometrial cancer_Homo sapiens_hsa05213 | 0.54548647 |
| 75 | Mismatch repair_Homo sapiens_hsa03430 | 0.53697469 |
| 76 | Salmonella infection_Homo sapiens_hsa05132 | 0.53115964 |
| 77 | Thyroid cancer_Homo sapiens_hsa05216 | 0.52328701 |
| 78 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.50511276 |
| 79 | Base excision repair_Homo sapiens_hsa03410 | 0.49816827 |
| 80 | RNA transport_Homo sapiens_hsa03013 | 0.48846682 |
| 81 | Tuberculosis_Homo sapiens_hsa05152 | 0.48550770 |
| 82 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.48246985 |
| 83 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.47611619 |
| 84 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.45022059 |
| 85 | Cell cycle_Homo sapiens_hsa04110 | 0.44811661 |
| 86 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.44367379 |
| 87 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.43809223 |
| 88 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.43698774 |
| 89 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.42947550 |
| 90 | Phototransduction_Homo sapiens_hsa04744 | 0.41648508 |
| 91 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.41555435 |
| 92 | Homologous recombination_Homo sapiens_hsa03440 | 0.40811555 |
| 93 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.40728541 |
| 94 | Endocytosis_Homo sapiens_hsa04144 | 0.40035620 |
| 95 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.39402250 |
| 96 | Malaria_Homo sapiens_hsa05144 | 0.39166648 |
| 97 | Adherens junction_Homo sapiens_hsa04520 | 0.36907081 |
| 98 | Pertussis_Homo sapiens_hsa05133 | 0.36062475 |
| 99 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.35895668 |
| 100 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.34326362 |
| 101 | RNA polymerase_Homo sapiens_hsa03020 | 0.33787024 |
| 102 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.31114862 |
| 103 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.30479779 |
| 104 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.30025293 |
| 105 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.30024089 |
| 106 | Alzheimers disease_Homo sapiens_hsa05010 | 0.26393976 |
| 107 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.26266925 |
| 108 | Proteasome_Homo sapiens_hsa03050 | 0.25765383 |
| 109 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.24623688 |
| 110 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.24066036 |
| 111 | Pathways in cancer_Homo sapiens_hsa05200 | 0.23803416 |
| 112 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.23182213 |
| 113 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.22833253 |
| 114 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.21482480 |
| 115 | Peroxisome_Homo sapiens_hsa04146 | 0.20475854 |
| 116 | Huntingtons disease_Homo sapiens_hsa05016 | 0.20178925 |
| 117 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.20162588 |
| 118 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.18970556 |
| 119 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.18714531 |
| 120 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.18211299 |
| 121 | Mineral absorption_Homo sapiens_hsa04978 | 0.17961147 |
| 122 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.17956023 |
| 123 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.17677617 |
| 124 | Salivary secretion_Homo sapiens_hsa04970 | 0.16551197 |
| 125 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.15961370 |
| 126 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.15952357 |
| 127 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.15653330 |
| 128 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.15437708 |
| 129 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.13827863 |
| 130 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.11706703 |
| 131 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.11511805 |
| 132 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.10037311 |
| 133 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.08576934 |
| 134 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.06570361 |
| 135 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.05985004 |
| 136 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.05641174 |
| 137 | Phagosome_Homo sapiens_hsa04145 | 0.05097887 |
| 138 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.03384719 |
| 139 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.03041595 |
| 140 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.02414729 |

