TRAV18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G8.52036590
2positive regulation of uterine smooth muscle contraction (GO:0070474)8.30470414
3negative T cell selection (GO:0043383)7.94117315
4tachykinin receptor signaling pathway (GO:0007217)7.19360331
5negative thymic T cell selection (GO:0045060)6.65142663
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.46516666
7regulation of uterine smooth muscle contraction (GO:0070472)6.44311722
8positive T cell selection (GO:0043368)6.33522363
9positive regulation of gamma-delta T cell activation (GO:0046645)5.97967227
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.58531349
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.47968852
12positive thymic T cell selection (GO:0045059)5.35855476
13cellular response to interleukin-15 (GO:0071350)5.35386421
14tolerance induction (GO:0002507)5.12799031
15thymic T cell selection (GO:0045061)5.07462108
16leukocyte aggregation (GO:0070486)5.05894345
17T cell migration (GO:0072678)4.85189651
18T cell selection (GO:0045058)4.84066213
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.80660561
20negative regulation of cell killing (GO:0031342)4.80660561
21antigen processing and presentation of endogenous antigen (GO:0019883)4.76367839
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.55233005
23regulation of T cell tolerance induction (GO:0002664)4.43748414
24response to interleukin-15 (GO:0070672)4.39798093
25adaptation of signaling pathway (GO:0023058)4.35990694
26regulation of gamma-delta T cell differentiation (GO:0045586)4.27509201
27positive regulation of tolerance induction (GO:0002645)4.26071826
28regulation of gamma-delta T cell activation (GO:0046643)4.13316173
29interferon-gamma production (GO:0032609)4.13093493
30positive regulation of alpha-beta T cell proliferation (GO:0046641)4.10270770
31positive regulation of natural killer cell mediated immunity (GO:0002717)4.05418558
32regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.03141768
33regulation of natural killer cell mediated immunity (GO:0002715)4.03141768
34positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.02625156
35negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.00422637
36T cell receptor signaling pathway (GO:0050852)4.00399408
37Arp2/3 complex-mediated actin nucleation (GO:0034314)4.00281894
38regulation of alpha-beta T cell proliferation (GO:0046640)3.95790676
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.95063881
40regulation of natural killer cell differentiation (GO:0032823)3.93684275
41detection of bacterium (GO:0016045)3.90850495
42regulation of feeding behavior (GO:0060259)3.90800829
43positive regulation of interleukin-4 production (GO:0032753)3.78373009
44regulation of defense response to virus by virus (GO:0050690)3.78294942
45histone H2A acetylation (GO:0043968)3.76317900
46detection of other organism (GO:0098543)3.69913349
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.67168641
48phosphate ion transport (GO:0006817)3.62188569
49actin nucleation (GO:0045010)3.62124394
50positive regulation of cell killing (GO:0031343)3.60248232
51regulation of tolerance induction (GO:0002643)3.59477104
52positive regulation of T cell cytokine production (GO:0002726)3.58211197
53activated T cell proliferation (GO:0050798)3.56559634
54positive regulation of protein homodimerization activity (GO:0090073)3.52608929
55negative regulation of T cell mediated immunity (GO:0002710)3.52165942
56purine-containing compound salvage (GO:0043101)3.51254185
57positive regulation of T cell mediated cytotoxicity (GO:0001916)3.49253243
58positive regulation of smooth muscle contraction (GO:0045987)3.47572037
59regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46982986
60regulation of regulatory T cell differentiation (GO:0045589)3.44352454
61positive regulation of calcium-mediated signaling (GO:0050850)3.43837378
62regulation of meiosis I (GO:0060631)3.42460839
63regulation of T cell receptor signaling pathway (GO:0050856)3.33304347
64regulation of cell killing (GO:0031341)3.31843704
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.31752177
66regulation of T cell mediated cytotoxicity (GO:0001914)3.31198305
67detection of light stimulus involved in sensory perception (GO:0050962)3.30828598
68detection of light stimulus involved in visual perception (GO:0050908)3.30828598
69positive regulation of natural killer cell differentiation (GO:0032825)3.30587272
70regulation of isotype switching to IgG isotypes (GO:0048302)3.30211571
71regulation of B cell receptor signaling pathway (GO:0050855)3.27990186
72regulation of interleukin-2 biosynthetic process (GO:0045076)3.26353600
73negative regulation of stress fiber assembly (GO:0051497)3.25520402
74positive regulation of blood pressure (GO:0045777)3.18588327
75positive regulation of T cell mediated immunity (GO:0002711)3.17631472
76signal complex assembly (GO:0007172)3.17620944
77positive regulation of humoral immune response (GO:0002922)3.16638359
78antigen receptor-mediated signaling pathway (GO:0050851)3.16509944
79peptidyl-tyrosine autophosphorylation (GO:0038083)3.15434124
80positive regulation of interleukin-2 production (GO:0032743)3.11542999
81grooming behavior (GO:0007625)3.10396948
82purine deoxyribonucleotide catabolic process (GO:0009155)3.07378965
83T cell differentiation (GO:0030217)3.07366334
84mast cell activation (GO:0045576)3.03771313
85positive regulation of T cell differentiation in thymus (GO:0033089)3.00521707
86hyperosmotic salinity response (GO:0042538)2.98521657
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97173022
88regulation of mitotic spindle checkpoint (GO:1903504)2.97173022
89regulation of dopamine metabolic process (GO:0042053)2.95584519
90regulation of catecholamine metabolic process (GO:0042069)2.95584519
91regulation of interleukin-4 production (GO:0032673)2.94286923
92alpha-beta T cell differentiation (GO:0046632)2.93278134
93regulation of T cell mediated immunity (GO:0002709)2.92365085
94positive regulation of lymphocyte mediated immunity (GO:0002708)2.91732665
95lymphocyte migration (GO:0072676)2.91105454
96T cell costimulation (GO:0031295)2.90499354
97regulation of T cell cytokine production (GO:0002724)2.88859571
98lymphocyte costimulation (GO:0031294)2.87390420
99NIK/NF-kappaB signaling (GO:0038061)2.84853927
100viral transcription (GO:0019083)2.81721336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.58538734
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.23595414
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.56620710
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.20279678
5GATA1_22025678_ChIP-Seq_K562_Human4.18996440
6RUNX_20019798_ChIP-Seq_JUKART_Human4.01867585
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.87726304
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.86420645
9MYB_26560356_Chip-Seq_TH2_Human3.28939446
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04845162
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71695913
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69913885
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.61490027
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.52184120
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35349790
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34888622
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.34315355
18UTX_26944678_Chip-Seq_JUKART_Human2.21077969
19GATA3_27048872_Chip-Seq_THYMUS_Human2.17985825
20MYB_26560356_Chip-Seq_TH1_Human2.01341654
21VDR_22108803_ChIP-Seq_LS180_Human1.97678427
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79792351
23RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.71609288
24GATA3_26560356_Chip-Seq_TH2_Human1.70424237
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66114578
26MAF_26560356_Chip-Seq_TH1_Human1.58597851
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51210234
28VDR_23849224_ChIP-Seq_CD4+_Human1.44724162
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39058078
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30968017
31MAF_26560356_Chip-Seq_TH2_Human1.25954549
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21342988
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19780982
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19145962
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19053285
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.18997300
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.18003766
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16535508
39ZNF274_21170338_ChIP-Seq_K562_Hela1.15936728
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11300417
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08726064
42EZH2_22144423_ChIP-Seq_EOC_Human1.08575093
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08542106
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06533747
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04929769
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04804933
47SPI1_23547873_ChIP-Seq_NB4_Human1.04693103
48NCOR_22424771_ChIP-Seq_293T_Human1.03806045
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.03284256
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.02190655
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00987089
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00781847
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.00660786
54TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98948518
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98335670
56CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97581716
57FOXP3_21729870_ChIP-Seq_TREG_Human0.94704531
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92476856
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88320155
60MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87859881
61BCL6_27268052_Chip-Seq_Bcells_Human0.87654276
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87389636
63PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86842539
64YY1_22570637_ChIP-Seq_MALME-3M_Human0.86374045
65AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85221911
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85046162
67SPI1_20517297_ChIP-Seq_HL60_Human0.84782307
68SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84329598
69ELF1_20517297_ChIP-Seq_JURKAT_Human0.83216032
70NFE2_27457419_Chip-Seq_LIVER_Mouse0.83191881
71MYC_18940864_ChIP-ChIP_HL60_Human0.80405503
72SPI1_23127762_ChIP-Seq_K562_Human0.80315461
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79948487
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79769743
75ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77247849
76ER_23166858_ChIP-Seq_MCF-7_Human0.77237677
77RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77117536
78IGF1R_20145208_ChIP-Seq_DFB_Human0.77071652
79ERA_21632823_ChIP-Seq_H3396_Human0.76842295
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.76822034
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.76347995
82FUS_26573619_Chip-Seq_HEK293_Human0.75013379
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.74411864
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74411864
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74246374
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73445707
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72311762
88NMYC_18555785_Chip-Seq_ESCs_Mouse0.72264027
89STAT1_20625510_ChIP-Seq_HELA_Human0.72026594
90NANOG_20526341_ChIP-Seq_ESCs_Human0.71392712
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71179466
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69753246
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69663664
94GATA2_22383799_ChIP-Seq_G1ME_Mouse0.69616922
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69064705
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68995623
97SOX2_18555785_Chip-Seq_ESCs_Mouse0.68607981
98ELK4_26923725_Chip-Seq_MESODERM_Mouse0.68581662
99PU1_27457419_Chip-Seq_LIVER_Mouse0.68124038
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.67355283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.81893120
2MP0005671_abnormal_response_to4.27476813
3MP0002138_abnormal_hepatobiliary_system3.15174356
4MP0002822_catalepsy2.98283636
5MP0001835_abnormal_antigen_presentation2.91028933
6MP0009333_abnormal_splenocyte_physiolog2.85410278
7MP0005451_abnormal_body_composition2.74885992
8MP0005000_abnormal_immune_tolerance2.68193539
9MP0005025_abnormal_response_to2.62700033
10MP0000604_amyloidosis2.57788435
11MP0003724_increased_susceptibility_to2.55020309
12MP0009785_altered_susceptibility_to2.52094314
13MP0001800_abnormal_humoral_immune2.47200350
14MP0001819_abnormal_immune_cell2.45897090
15MP0002420_abnormal_adaptive_immunity2.44933399
16MP0002723_abnormal_immune_serum2.30355774
17MP0000703_abnormal_thymus_morphology2.23314453
18MP0000685_abnormal_immune_system2.20402001
19MP0003436_decreased_susceptibility_to2.18866707
20MP0001790_abnormal_immune_system2.16694103
21MP0005387_immune_system_phenotype2.16694103
22MP0002398_abnormal_bone_marrow2.10468112
23MP0000372_irregular_coat_pigmentation2.10383928
24MP0001348_abnormal_lacrimal_gland2.08963092
25MP0002452_abnormal_antigen_presenting2.06114216
26MP0003252_abnormal_bile_duct2.01507716
27MP0000716_abnormal_immune_system1.99379405
28MP0005410_abnormal_fertilization1.94937861
29MP0002419_abnormal_innate_immunity1.90093286
30MP0002722_abnormal_immune_system1.87092325
31MP0004947_skin_inflammation1.86207281
32MP0003866_abnormal_defecation1.86055023
33MP0000689_abnormal_spleen_morphology1.81662884
34MP0002405_respiratory_system_inflammati1.81379538
35MP0002735_abnormal_chemical_nociception1.75246957
36MP0002148_abnormal_hypersensitivity_rea1.75137617
37MP0002132_abnormal_respiratory_system1.72776415
38MP0002102_abnormal_ear_morphology1.70993480
39MP0003646_muscle_fatigue1.68841032
40MP0001873_stomach_inflammation1.54831730
41MP0010155_abnormal_intestine_physiology1.54673280
42MP0002429_abnormal_blood_cell1.48038263
43MP0005645_abnormal_hypothalamus_physiol1.46711032
44MP0001845_abnormal_inflammatory_respons1.46274759
45MP0002166_altered_tumor_susceptibility1.45290966
46MP0003690_abnormal_glial_cell1.42633029
47MP0005075_abnormal_melanosome_morpholog1.32711141
48MP0005377_hearing/vestibular/ear_phenot1.31492458
49MP0003878_abnormal_ear_physiology1.31492458
50MP0008995_early_reproductive_senescence1.28563634
51MP0001765_abnormal_ion_homeostasis1.26288237
52MP0004510_myositis1.26159394
53MP0002163_abnormal_gland_morphology1.22113579
54MP0009765_abnormal_xenobiotic_induced1.19893251
55MP0002277_abnormal_respiratory_mucosa1.19088203
56MP0002693_abnormal_pancreas_physiology1.18560294
57MP0002933_joint_inflammation1.18500041
58MP0008872_abnormal_physiological_respon1.16713721
59MP0003075_altered_response_to1.16189018
60MP0002396_abnormal_hematopoietic_system1.15556669
61MP0004381_abnormal_hair_follicle1.15149047
62MP0003183_abnormal_peptide_metabolism1.12203821
63MP0001533_abnormal_skeleton_physiology1.08667079
64MP0002006_tumorigenesis1.07636685
65MP0002733_abnormal_thermal_nociception1.05983168
66MP0002928_abnormal_bile_duct1.03217066
67MP0004130_abnormal_muscle_cell1.03002707
68MP0009840_abnormal_foam_cell1.02993402
69MP0008469_abnormal_protein_level1.02715798
70MP0003786_premature_aging1.01634830
71MP0003880_abnormal_central_pattern1.01568049
72MP0005464_abnormal_platelet_physiology1.00850078
73MP0003300_gastrointestinal_ulcer1.00645593
74MP0009764_decreased_sensitivity_to0.96022031
75MP0009379_abnormal_foot_pigmentation0.93154756
76MP0006276_abnormal_autonomic_nervous0.86716532
77MP0009763_increased_sensitivity_to0.83502761
78MP0005636_abnormal_mineral_homeostasis0.83238976
79MP0002837_dystrophic_cardiac_calcinosis0.81656666
80MP0000465_gastrointestinal_hemorrhage0.79894299
81MP0004145_abnormal_muscle_electrophysio0.78789930
82MP0005551_abnormal_eye_electrophysiolog0.78469419
83MP0003448_altered_tumor_morphology0.74769319
84MP0000678_abnormal_parathyroid_gland0.74739241
85MP0001119_abnormal_female_reproductive0.73060172
86MP0004019_abnormal_vitamin_homeostasis0.67171878
87MP0001970_abnormal_pain_threshold0.66998995
88MP0006072_abnormal_retinal_apoptosis0.62754638
89MP0001501_abnormal_sleep_pattern0.61246626
90MP0008961_abnormal_basal_metabolism0.60070715
91MP0000538_abnormal_urinary_bladder0.58927683
92MP0010329_abnormal_lipoprotein_level0.56771096
93MP0000383_abnormal_hair_follicle0.55043843
94MP0001545_abnormal_hematopoietic_system0.53625219
95MP0005397_hematopoietic_system_phenotyp0.53625219
96MP0003137_abnormal_impulse_conducting0.52909660
97MP0003806_abnormal_nucleotide_metabolis0.52897116
98MP0009642_abnormal_blood_homeostasis0.51658092
99MP0005379_endocrine/exocrine_gland_phen0.50564812
100MP0000631_abnormal_neuroendocrine_gland0.50192240

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)6.08431784
2Severe combined immunodeficiency (HP:0004430)5.73779022
3Stomatitis (HP:0010280)5.44622003
4Elevated erythrocyte sedimentation rate (HP:0003565)4.58887310
5Combined immunodeficiency (HP:0005387)4.53529880
6T lymphocytopenia (HP:0005403)4.40817682
7Increased IgM level (HP:0003496)4.27131250
8IgM deficiency (HP:0002850)4.25310918
9Chronic diarrhea (HP:0002028)4.14887862
10Loss of speech (HP:0002371)4.13902576
11Optic neuritis (HP:0100653)4.06128072
12Retrobulbar optic neuritis (HP:0100654)4.06128072
13Abnormality of T cell number (HP:0011839)4.04559263
14Increased intramyocellular lipid droplets (HP:0012240)4.04273681
15Abnormality of B cell number (HP:0010975)4.00750153
16B lymphocytopenia (HP:0010976)3.95029702
17Abnormality of T cells (HP:0002843)3.93398584
18Myositis (HP:0100614)3.81787097
19Hyperlipoproteinemia (HP:0010980)3.77080652
20Renal cortical cysts (HP:0000803)3.72345094
21Eczematoid dermatitis (HP:0000976)3.63954326
22Thyroiditis (HP:0100646)3.58287886
23Autoimmune hemolytic anemia (HP:0001890)3.57939334
24Orchitis (HP:0100796)3.54900627
25Congenital stationary night blindness (HP:0007642)3.51509632
26Encephalitis (HP:0002383)3.42528444
27Absent rod-and cone-mediated responses on ERG (HP:0007688)3.41776668
28Abnormality of T cell physiology (HP:0011840)3.36010406
29Recurrent bronchitis (HP:0002837)3.33719748
30Increased muscle lipid content (HP:0009058)3.33643871
31Abnormality of eosinophils (HP:0001879)3.20663804
32Generalized aminoaciduria (HP:0002909)3.18754238
33Diastasis recti (HP:0001540)3.16058197
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.02151289
35Choroideremia (HP:0001139)2.94805329
36Abnormal rod and cone electroretinograms (HP:0008323)2.85921181
37Bronchitis (HP:0012387)2.78449857
38Panhypogammaglobulinemia (HP:0003139)2.77738901
39Keratoconjunctivitis sicca (HP:0001097)2.66487747
40Recurrent fungal infections (HP:0002841)2.66101975
41Dysphonia (HP:0001618)2.64933143
42Parakeratosis (HP:0001036)2.62599389
43Stenosis of the external auditory canal (HP:0000402)2.60959515
44Lymphopenia (HP:0001888)2.56007499
45IgA deficiency (HP:0002720)2.55023248
46Leukocytosis (HP:0001974)2.54900528
47Eosinophilia (HP:0001880)2.45897893
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42879419
49Keratoconjunctivitis (HP:0001096)2.42745214
50Proximal tubulopathy (HP:0000114)2.38523697
51Aplastic anemia (HP:0001915)2.36567995
52Chronic mucocutaneous candidiasis (HP:0002728)2.36195377
53Recurrent cutaneous fungal infections (HP:0011370)2.36195377
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.32030153
55Gangrene (HP:0100758)2.26572240
56Limb dystonia (HP:0002451)2.24716815
57Recurrent otitis media (HP:0000403)2.24205561
58Severe visual impairment (HP:0001141)2.20283611
59Mediastinal lymphadenopathy (HP:0100721)2.18254567
60Granulocytopenia (HP:0001913)2.17530322
61Abnormality of macrophages (HP:0004311)2.17016423
62Lymphoma (HP:0002665)2.16881158
63Meningitis (HP:0001287)2.14885157
64Hypergammaglobulinemia (HP:0010702)2.14585456
65Keratitis (HP:0000491)2.09658770
663-Methylglutaconic aciduria (HP:0003535)2.09032748
67Bronchiectasis (HP:0002110)2.08326827
68Pancytopenia (HP:0001876)2.06979336
69Chronic obstructive pulmonary disease (HP:0006510)2.03033417
70Obstructive lung disease (HP:0006536)2.03033417
71Xanthomatosis (HP:0000991)2.00753847
72Vasculitis (HP:0002633)1.99274150
73Chronic bronchitis (HP:0004469)1.98057289
74Hyperphosphaturia (HP:0003109)1.97500325
75Pustule (HP:0200039)1.97364738
76Gastrointestinal infarctions (HP:0005244)1.97086092
77Increased hepatocellular lipid droplets (HP:0006565)1.93827644
78Abnormality of the renal cortex (HP:0011035)1.93648612
79Abnormal respiratory motile cilium physiology (HP:0012261)1.90108532
80Mutism (HP:0002300)1.89496390
81Posterior subcapsular cataract (HP:0007787)1.88779669
82Joint swelling (HP:0001386)1.87594132
83Hypercortisolism (HP:0001578)1.86886428
84Hypercholesterolemia (HP:0003124)1.83762149
85Hemoptysis (HP:0002105)1.82132010
86Global brain atrophy (HP:0002283)1.80871272
87Recurrent skin infections (HP:0001581)1.80099846
88Anorexia (HP:0002039)1.79194186
89Dyschromatopsia (HP:0007641)1.78396406
90Radial bowing (HP:0002986)1.78006666
91Oligodactyly (hands) (HP:0001180)1.76420833
92Pendular nystagmus (HP:0012043)1.75748457
93Spastic paraparesis (HP:0002313)1.74541967
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73700592
95Increased IgE level (HP:0003212)1.70283541
96Pulmonary infiltrates (HP:0002113)1.70194330
97Type 2 muscle fiber atrophy (HP:0003554)1.69717254
98Abolished electroretinogram (ERG) (HP:0000550)1.68923811
99Bony spicule pigmentary retinopathy (HP:0007737)1.68516927
100Muscle fiber atrophy (HP:0100295)1.66247699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL27.50092724
2TESK24.13261326
3TXK3.91248878
4KDR3.26760273
5PASK3.16254381
6MAP4K12.88703311
7TESK12.61913160
8CDK192.53526850
9EPHB12.48556835
10ITK2.31609348
11CSK2.15202358
12FES2.04018550
13TEC1.90540536
14BTK1.89789625
15ZAP701.85767654
16TLK11.84953148
17STK241.84895599
18GRK61.78018664
19STK161.76163353
20JAK31.72692394
21SYK1.70984527
22LCK1.62764329
23LIMK11.58640346
24ADRBK21.51902920
25PRPF4B1.44893475
26MAP3K31.33631439
27NEK61.28731540
28IKBKE1.28648666
29MAP2K61.27561092
30TAOK21.16683421
31ERBB31.07827561
32HCK1.05552977
33CAMKK11.04098225
34MAP2K31.02507630
35EIF2AK11.01737368
36TRPM70.99435687
37LYN0.97440610
38FRK0.91981832
39PRKCQ0.86990852
40TAOK10.86794033
41SIK30.84593565
42WNK40.83960129
43STK38L0.82710438
44RIPK40.82214695
45JAK10.79809790
46EPHA30.77847410
47BLK0.75449452
48KIT0.75071130
49BUB10.73844510
50GRK70.66001282
51IKBKB0.65626507
52CDK60.62706414
53FYN0.62375353
54TAOK30.59895688
55IRAK10.56250461
56DAPK10.54840468
57FGFR20.53338184
58IGF1R0.49413932
59STK100.48878062
60PINK10.46573461
61PIM10.45447721
62PIK3CG0.45046362
63ZAK0.43424512
64MAPKAPK30.41590747
65ACVR1B0.41427312
66CSF1R0.40152643
67TYK20.39624414
68ROCK10.39286508
69CAMKK20.36735781
70ILK0.36169564
71SGK20.35677262
72TNK20.35627101
73MST40.35387707
74INSRR0.35114075
75BCKDK0.35072158
76INSR0.34514629
77ERN10.33885745
78TYRO30.33084746
79PRKCD0.32419040
80EGFR0.32325387
81RPS6KB20.31056698
82AKT30.30724922
83FGR0.30261260
84OBSCN0.29776075
85MYLK0.28988443
86ABL10.28452458
87MAP3K120.28029007
88JAK20.27476927
89MAP3K40.27167125
90ADRBK10.26603509
91MAPK110.26055191
92SGK2230.26031261
93SGK4940.26031261
94CDC42BPA0.26002738
95LRRK20.24604604
96MAP2K70.24078493
97PRKCH0.22115383
98PTK2B0.22108453
99FGFR30.21214473
100MINK10.21092484

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.02453133
2Antigen processing and presentation_Homo sapiens_hsa046123.72566757
3T cell receptor signaling pathway_Homo sapiens_hsa046603.42944058
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.78873847
5Hematopoietic cell lineage_Homo sapiens_hsa046402.53765058
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.32486636
7Ribosome_Homo sapiens_hsa030102.27568482
8Graft-versus-host disease_Homo sapiens_hsa053322.27434740
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04027103
10Measles_Homo sapiens_hsa051621.97328900
11Allograft rejection_Homo sapiens_hsa053301.92651239
12Autoimmune thyroid disease_Homo sapiens_hsa053201.92469959
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77000362
14Proteasome_Homo sapiens_hsa030501.75191747
15Renin-angiotensin system_Homo sapiens_hsa046141.66201107
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.65025072
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.58724798
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55015292
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47899796
20Type I diabetes mellitus_Homo sapiens_hsa049401.38787213
21Phototransduction_Homo sapiens_hsa047441.34537085
22Malaria_Homo sapiens_hsa051441.34521805
23Viral myocarditis_Homo sapiens_hsa054161.33450312
24One carbon pool by folate_Homo sapiens_hsa006701.28861132
25Shigellosis_Homo sapiens_hsa051311.19595397
26Legionellosis_Homo sapiens_hsa051341.18919223
27Renin secretion_Homo sapiens_hsa049241.18833668
28Taste transduction_Homo sapiens_hsa047421.14844726
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11634890
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10523298
31Starch and sucrose metabolism_Homo sapiens_hsa005001.09323862
32Osteoclast differentiation_Homo sapiens_hsa043801.09180431
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.07034297
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.06668017
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03141600
36African trypanosomiasis_Homo sapiens_hsa051431.00964867
37NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97969697
38Arachidonic acid metabolism_Homo sapiens_hsa005900.97233699
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97008289
40Nitrogen metabolism_Homo sapiens_hsa009100.96068240
41Chemokine signaling pathway_Homo sapiens_hsa040620.95499356
42Chemical carcinogenesis_Homo sapiens_hsa052040.94498171
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94206695
44TNF signaling pathway_Homo sapiens_hsa046680.84722357
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83412208
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.82804345
47Herpes simplex infection_Homo sapiens_hsa051680.80376931
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.75393866
49Retinol metabolism_Homo sapiens_hsa008300.75138886
50Staphylococcus aureus infection_Homo sapiens_hsa051500.71196228
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70780162
52Platelet activation_Homo sapiens_hsa046110.70378927
53Apoptosis_Homo sapiens_hsa042100.67213466
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.64277147
55Asthma_Homo sapiens_hsa053100.63513497
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62777775
57HTLV-I infection_Homo sapiens_hsa051660.62739262
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59729841
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59480961
60Linoleic acid metabolism_Homo sapiens_hsa005910.58161044
61Caffeine metabolism_Homo sapiens_hsa002320.56578535
62Endocytosis_Homo sapiens_hsa041440.55606835
63Leishmaniasis_Homo sapiens_hsa051400.55108202
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55050305
65Homologous recombination_Homo sapiens_hsa034400.54025322
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53203613
67Calcium signaling pathway_Homo sapiens_hsa040200.52728081
68Toxoplasmosis_Homo sapiens_hsa051450.51855381
69Morphine addiction_Homo sapiens_hsa050320.49713159
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49526119
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48602503
72Pertussis_Homo sapiens_hsa051330.47995044
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45504432
74MAPK signaling pathway_Homo sapiens_hsa040100.45316739
75Tuberculosis_Homo sapiens_hsa051520.44189162
76cAMP signaling pathway_Homo sapiens_hsa040240.43056320
77Nicotine addiction_Homo sapiens_hsa050330.41454743
78Salivary secretion_Homo sapiens_hsa049700.40657663
79Cardiac muscle contraction_Homo sapiens_hsa042600.40473846
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39695748
81Olfactory transduction_Homo sapiens_hsa047400.39281888
82Rheumatoid arthritis_Homo sapiens_hsa053230.38345225
83FoxO signaling pathway_Homo sapiens_hsa040680.38027975
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37282073
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36169338
86Ovarian steroidogenesis_Homo sapiens_hsa049130.33534378
87Salmonella infection_Homo sapiens_hsa051320.33457140
88Regulation of autophagy_Homo sapiens_hsa041400.32112268
89Type II diabetes mellitus_Homo sapiens_hsa049300.31188504
90B cell receptor signaling pathway_Homo sapiens_hsa046620.29735345
91Oxidative phosphorylation_Homo sapiens_hsa001900.28821295
92Gastric acid secretion_Homo sapiens_hsa049710.27095911
93Ras signaling pathway_Homo sapiens_hsa040140.26536197
94Epstein-Barr virus infection_Homo sapiens_hsa051690.24058745
95Viral carcinogenesis_Homo sapiens_hsa052030.22727050
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20589996
97Influenza A_Homo sapiens_hsa051640.20580106
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19846371
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18833948
100Hepatitis C_Homo sapiens_hsa051600.18399589

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