TRAV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.99879622
2negative T cell selection (GO:0043383)6.87758349
3activated T cell proliferation (GO:0050798)6.46889422
4tolerance induction (GO:0002507)6.13578866
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.06736782
6negative thymic T cell selection (GO:0045060)6.02660848
7positive regulation of gamma-delta T cell activation (GO:0046645)5.92844841
8negative regulation of cell killing (GO:0031342)5.92121387
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.92121387
10positive T cell selection (GO:0043368)5.71901576
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.61667982
12thymic T cell selection (GO:0045061)5.44468559
13regulation of B cell receptor signaling pathway (GO:0050855)5.43942167
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41481832
15T cell migration (GO:0072678)5.39747593
16T cell selection (GO:0045058)5.38694071
17regulation of regulatory T cell differentiation (GO:0045589)5.35267193
18regulation of T cell tolerance induction (GO:0002664)5.04242521
19positive thymic T cell selection (GO:0045059)5.01816928
20production of molecular mediator involved in inflammatory response (GO:0002532)4.95824345
21regulation of gamma-delta T cell differentiation (GO:0045586)4.93915827
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.85259273
23antigen processing and presentation of endogenous antigen (GO:0019883)4.77437474
24response to interleukin-15 (GO:0070672)4.65641907
25cellular response to interleukin-15 (GO:0071350)4.64805704
26positive regulation of tolerance induction (GO:0002645)4.50397949
27regulation of isotype switching to IgG isotypes (GO:0048302)4.48417193
28regulation of gamma-delta T cell activation (GO:0046643)4.45618436
29regulation of interleukin-2 biosynthetic process (GO:0045076)4.38174560
30T cell receptor signaling pathway (GO:0050852)4.32592133
31regulation of tolerance induction (GO:0002643)4.20417607
32regulation of interferon-beta biosynthetic process (GO:0045357)4.13931510
33regulation of alpha-beta T cell proliferation (GO:0046640)3.99512183
34regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.96722801
35positive regulation of T cell mediated cytotoxicity (GO:0001916)3.93253526
36antigen processing and presentation via MHC class Ib (GO:0002475)3.87026554
37antigen receptor-mediated signaling pathway (GO:0050851)3.85785135
38leukocyte aggregation (GO:0070486)3.82166030
39interferon-gamma production (GO:0032609)3.74733300
40regulation of T cell mediated cytotoxicity (GO:0001914)3.72956514
41alpha-beta T cell differentiation (GO:0046632)3.69773063
42positive regulation of granulocyte differentiation (GO:0030854)3.63672399
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.62447745
44regulation of chronic inflammatory response (GO:0002676)3.57592484
45positive regulation of humoral immune response (GO:0002922)3.57347743
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.55967241
47regulation of B cell differentiation (GO:0045577)3.54466343
48negative regulation of T cell mediated immunity (GO:0002710)3.53320464
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52739078
50negative regulation of leukocyte mediated immunity (GO:0002704)3.50003364
51cytolysis (GO:0019835)3.49001092
52regulation of T cell receptor signaling pathway (GO:0050856)3.48196277
53positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.47574980
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47370607
55alpha-beta T cell activation (GO:0046631)3.47127871
56cellular response to type I interferon (GO:0071357)3.45666208
57type I interferon signaling pathway (GO:0060337)3.45666208
58response to type I interferon (GO:0034340)3.43411058
59regulation of natural killer cell mediated immunity (GO:0002715)3.41722745
60regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.41722745
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.41408317
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40226146
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.40226146
64modulation by symbiont of host immune response (GO:0052553)3.40226146
65positive regulation by symbiont of host defense response (GO:0052509)3.40226146
66modulation by symbiont of host defense response (GO:0052031)3.40226146
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40226146
68purine-containing compound salvage (GO:0043101)3.39718766
69positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.39236167
70regulation of alpha-beta T cell activation (GO:0046634)3.38090955
71T cell homeostasis (GO:0043029)3.37145668
72positive regulation of interleukin-2 production (GO:0032743)3.35390615
73positive regulation of B cell differentiation (GO:0045579)3.33787539
74positive regulation of alpha-beta T cell activation (GO:0046635)3.33397459
75T cell costimulation (GO:0031295)3.30467201
76positive regulation of T cell differentiation in thymus (GO:0033089)3.29858082
77CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.28913855
78lymphocyte migration (GO:0072676)3.27844675
79lymphocyte costimulation (GO:0031294)3.26630178
80regulation of leukocyte mediated cytotoxicity (GO:0001910)3.24700947
81positive regulation of interleukin-4 production (GO:0032753)3.20845945
82positive regulation of cell killing (GO:0031343)3.19126557
83CD4-positive, alpha-beta T cell activation (GO:0035710)3.14835118
84regulation of defense response to virus by host (GO:0050691)3.14185883
85mast cell activation (GO:0045576)3.13901283
86positive regulation of alpha-beta T cell differentiation (GO:0046638)3.10378928
87negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.06862642
88regulation of cell killing (GO:0031341)3.04843458
89cytidine metabolic process (GO:0046087)3.02335367
90cytidine catabolic process (GO:0006216)3.02335367
91cytidine deamination (GO:0009972)3.02335367
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01564732
93actin nucleation (GO:0045010)3.01407603
94T cell differentiation (GO:0030217)3.00129185
95positive regulation of calcium-mediated signaling (GO:0050850)2.98022053
96detection of bacterium (GO:0016045)2.96526000
97positive regulation of T cell mediated immunity (GO:0002711)2.96352476
98regulation of alpha-beta T cell differentiation (GO:0046637)2.95922104
99positive regulation of natural killer cell differentiation (GO:0032825)2.95303960
100B cell receptor signaling pathway (GO:0050853)2.91267386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.41763998
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.97085864
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.96635080
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.34399740
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17488955
6RUNX_20019798_ChIP-Seq_JUKART_Human3.88257278
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80148022
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.63766415
9MYB_26560356_Chip-Seq_TH2_Human3.52250289
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.51652352
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32551137
12IRF8_21731497_ChIP-ChIP_J774_Mouse3.27046851
13MAF_26560356_Chip-Seq_TH1_Human3.11797499
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.10153684
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.03391421
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02106629
17UTX_26944678_Chip-Seq_JUKART_Human2.84851165
18MYB_26560356_Chip-Seq_TH1_Human2.74927873
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.74205239
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48433108
21MAF_26560356_Chip-Seq_TH2_Human2.34134788
22GATA3_27048872_Chip-Seq_THYMUS_Human2.23013300
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14304515
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.13814199
25MYC_22102868_ChIP-Seq_BL_Human2.13656549
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.11327042
27SPI1_23547873_ChIP-Seq_NB4_Human2.09503082
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.06803070
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96927964
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.93807838
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80908739
32GATA3_26560356_Chip-Seq_TH2_Human1.74410518
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70885936
34VDR_21846776_ChIP-Seq_THP-1_Human1.67965099
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64203575
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61475199
37VDR_24763502_ChIP-Seq_THP-1_Human1.60877059
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54193395
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49761750
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49217324
41CIITA_25753668_ChIP-Seq_RAJI_Human1.46998744
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45192915
43SCL_19346495_ChIP-Seq_HPC-7_Human1.45113242
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44249099
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41918052
46TCF7_22412390_ChIP-Seq_EML_Mouse1.41540601
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38173211
48SPI1_23127762_ChIP-Seq_K562_Human1.32921814
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30954618
50VDR_23849224_ChIP-Seq_CD4+_Human1.30633250
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24240564
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18574781
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15445865
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13914145
55KDM2B_26808549_Chip-Seq_DND41_Human1.10194116
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08131493
57BCL6_27268052_Chip-Seq_Bcells_Human1.06021730
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04349569
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01792248
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01130698
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00656618
62SPI1_20517297_ChIP-Seq_HL60_Human1.00503945
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00456701
64BCOR_27268052_Chip-Seq_Bcells_Human0.98958202
65KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97740679
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96942308
67PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95477100
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94022667
69KDM2B_26808549_Chip-Seq_JURKAT_Human0.93499117
70CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92661278
71VDR_24787735_ChIP-Seq_THP-1_Human0.92033628
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92016474
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92012478
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.91740559
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91636653
76FOXP3_21729870_ChIP-Seq_TREG_Human0.90903086
77YY1_22570637_ChIP-Seq_MALME-3M_Human0.90166676
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90099432
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90096345
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89650203
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88778836
82STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88317541
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87900114
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85252785
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84588967
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84462407
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83511037
88PU_27001747_Chip-Seq_BMDM_Mouse0.82496071
89P300_27268052_Chip-Seq_Bcells_Human0.82279227
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82114276
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81839184
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81715899
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81557258
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81472120
95GATA3_26560356_Chip-Seq_TH1_Human0.80942543
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78234894
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.77296198
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.74988747
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74319879
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73123859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.61343429
2MP0003763_abnormal_thymus_physiology5.22125760
3MP0003436_decreased_susceptibility_to4.19121076
4MP0005000_abnormal_immune_tolerance3.17618523
5MP0001835_abnormal_antigen_presentation3.17103640
6MP0001873_stomach_inflammation3.13605516
7MP0001800_abnormal_humoral_immune3.00158588
8MP0005387_immune_system_phenotype2.95605511
9MP0001790_abnormal_immune_system2.95605511
10MP0000685_abnormal_immune_system2.94884955
11MP0009333_abnormal_splenocyte_physiolog2.88524714
12MP0009785_altered_susceptibility_to2.88449405
13MP0002420_abnormal_adaptive_immunity2.74323554
14MP0002254_reproductive_system_inflammat2.74127853
15MP0001819_abnormal_immune_cell2.70068751
16MP0003866_abnormal_defecation2.67390402
17MP0002166_altered_tumor_susceptibility2.63142676
18MP0002723_abnormal_immune_serum2.56254135
19MP0005025_abnormal_response_to2.54692031
20MP0003724_increased_susceptibility_to2.50571550
21MP0002452_abnormal_antigen_presenting2.48005237
22MP0002405_respiratory_system_inflammati2.40456853
23MP0002419_abnormal_innate_immunity2.32021692
24MP0006082_CNS_inflammation2.31017663
25MP0010155_abnormal_intestine_physiology2.30001413
26MP0001348_abnormal_lacrimal_gland2.29483129
27MP0002148_abnormal_hypersensitivity_rea2.26351733
28MP0000703_abnormal_thymus_morphology2.25962678
29MP0002398_abnormal_bone_marrow2.23196655
30MP0005310_abnormal_salivary_gland2.22437903
31MP0000716_abnormal_immune_system2.10867514
32MP0002722_abnormal_immune_system1.88683950
33MP0002006_tumorigenesis1.85559162
34MP0000689_abnormal_spleen_morphology1.74611267
35MP0001845_abnormal_inflammatory_respons1.73331970
36MP0001533_abnormal_skeleton_physiology1.71939104
37MP0004381_abnormal_hair_follicle1.69580769
38MP0004947_skin_inflammation1.68633420
39MP0002429_abnormal_blood_cell1.63771313
40MP0002277_abnormal_respiratory_mucosa1.61715447
41MP0003300_gastrointestinal_ulcer1.47674844
42MP0002009_preneoplasia1.33316508
43MP0000465_gastrointestinal_hemorrhage1.31806390
44MP0002933_joint_inflammation1.30791939
45MP0002396_abnormal_hematopoietic_system1.26815197
46MP0003950_abnormal_plasma_membrane1.25520549
47MP0001851_eye_inflammation1.23783762
48MP0008469_abnormal_protein_level1.13662318
49MP0005464_abnormal_platelet_physiology1.13583155
50MP0001853_heart_inflammation1.13163477
51MP0001346_abnormal_lacrimal_gland1.08521459
52MP0005075_abnormal_melanosome_morpholog1.05654800
53MP0003303_peritoneal_inflammation0.98581366
54MP0002132_abnormal_respiratory_system0.97842887
55MP0008057_abnormal_DNA_replication0.95228041
56MP0000490_abnormal_crypts_of0.94903668
57MP0003448_altered_tumor_morphology0.94300968
58MP0002163_abnormal_gland_morphology0.93327022
59MP0003045_fibrosis0.92137113
60MP0002138_abnormal_hepatobiliary_system0.91343498
61MP0002876_abnormal_thyroid_physiology0.90751250
62MP0005451_abnormal_body_composition0.88509227
63MP0008569_lethality_at_weaning0.76421462
64MP0009764_decreased_sensitivity_to0.76326457
65MP0001919_abnormal_reproductive_system0.76275003
66MP0005166_decreased_susceptibility_to0.73824173
67MP0002019_abnormal_tumor_incidence0.69814440
68MP0008877_abnormal_DNA_methylation0.69327607
69MP0003191_abnormal_cellular_cholesterol0.68440309
70MP0003806_abnormal_nucleotide_metabolis0.68180536
71MP0003786_premature_aging0.68066392
72MP0002090_abnormal_vision0.66750104
73MP0000372_irregular_coat_pigmentation0.66380237
74MP0005645_abnormal_hypothalamus_physiol0.63944638
75MP0003690_abnormal_glial_cell0.63858526
76MP0009763_increased_sensitivity_to0.63361266
77MP0005390_skeleton_phenotype0.63123677
78MP0002998_abnormal_bone_remodeling0.62289659
79MP0001663_abnormal_digestive_system0.61981478
80MP0008058_abnormal_DNA_repair0.61685790
81MP0002693_abnormal_pancreas_physiology0.61594092
82MP0000858_altered_metastatic_potential0.60758861
83MP0005167_abnormal_blood-brain_barrier0.55168445
84MP0002136_abnormal_kidney_physiology0.54646692
85MP0000249_abnormal_blood_vessel0.51179558
86MP0000604_amyloidosis0.51087179
87MP0000015_abnormal_ear_pigmentation0.49650611
88MP0000609_abnormal_liver_physiology0.48706337
89MP0009840_abnormal_foam_cell0.46856535
90MP0005379_endocrine/exocrine_gland_phen0.46395197
91MP0005647_abnormal_sex_gland0.46276590
92MP0003795_abnormal_bone_structure0.43108473
93MP0003075_altered_response_to0.42642100
94MP0001502_abnormal_circadian_rhythm0.41533193
95MP0008004_abnormal_stomach_pH0.39979322
96MP0008961_abnormal_basal_metabolism0.39661037
97MP0004883_abnormal_blood_vessel0.39206655
98MP0009643_abnormal_urine_homeostasis0.38799758
99MP0002736_abnormal_nociception_after0.36594007
100MP0000920_abnormal_myelination0.36075523

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)8.24127496
2Autoimmune thrombocytopenia (HP:0001973)6.95074727
3Visual hallucinations (HP:0002367)5.99521172
4Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)5.87963128
5Increased neuronal autofluorescent lipopigment (HP:0002074)5.71333314
6T lymphocytopenia (HP:0005403)5.68194340
7Abnormality of T cell number (HP:0011839)5.32323477
8Abnormality of T cells (HP:0002843)5.23907652
9Increased cerebral lipofuscin (HP:0011813)5.04041965
10Stomatitis (HP:0010280)5.03749719
11Abnormality of T cell physiology (HP:0011840)4.79584586
12Elevated erythrocyte sedimentation rate (HP:0003565)4.62967549
13Eczematoid dermatitis (HP:0000976)4.50922250
14Recurrent viral infections (HP:0004429)4.31187528
15Prostate neoplasm (HP:0100787)4.30742499
16Lymphopenia (HP:0001888)4.20298672
17Testicular atrophy (HP:0000029)3.93821045
18Abnormality of cells of the lymphoid lineage (HP:0012140)3.87981521
19Gastrointestinal infarctions (HP:0005244)3.70783898
20Vasculitis (HP:0002633)3.59348770
21Myositis (HP:0100614)3.58491721
22Recurrent fungal infections (HP:0002841)3.54658649
23Tetraparesis (HP:0002273)3.50948088
24IgG deficiency (HP:0004315)3.47251173
25Severe combined immunodeficiency (HP:0004430)3.41671536
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.34419765
27Keratoconjunctivitis (HP:0001096)3.30991700
28Recurrent cutaneous fungal infections (HP:0011370)3.28233191
29Chronic mucocutaneous candidiasis (HP:0002728)3.28233191
30Retrobulbar optic neuritis (HP:0100654)3.25055272
31Optic neuritis (HP:0100653)3.25055272
32IgM deficiency (HP:0002850)3.18443294
33Abnormality of the prostate (HP:0008775)3.12757656
34Lymphoma (HP:0002665)3.07503171
35Orchitis (HP:0100796)3.04183080
36Dyschromatopsia (HP:0007641)3.02927106
37Abnormality of macrophages (HP:0004311)2.96038425
38Mediastinal lymphadenopathy (HP:0100721)2.87914100
39Increased IgM level (HP:0003496)2.87573248
40Recurrent abscess formation (HP:0002722)2.87557000
41Pustule (HP:0200039)2.87105142
42Recurrent bacterial skin infections (HP:0005406)2.86917361
43Meningitis (HP:0001287)2.78960976
44Granulocytopenia (HP:0001913)2.78403206
45Encephalitis (HP:0002383)2.77832965
46Abnormality of eosinophils (HP:0001879)2.77676004
47Increased IgE level (HP:0003212)2.74175872
48Combined immunodeficiency (HP:0005387)2.73824760
49Eosinophilia (HP:0001880)2.67790415
50Chronic obstructive pulmonary disease (HP:0006510)2.67595600
51Obstructive lung disease (HP:0006536)2.67595600
52Chronic diarrhea (HP:0002028)2.67592867
53Spastic diplegia (HP:0001264)2.65230261
54Leukocytosis (HP:0001974)2.64958831
55Recurrent bronchitis (HP:0002837)2.63194156
56Keratoconjunctivitis sicca (HP:0001097)2.48387717
57Recurrent gram-negative bacterial infections (HP:0005420)2.46866886
58Chest pain (HP:0100749)2.44736686
59Panhypogammaglobulinemia (HP:0003139)2.42240989
60Recurrent skin infections (HP:0001581)2.42198052
61Papilloma (HP:0012740)2.40390181
62Verrucae (HP:0200043)2.40390181
63Pulmonary infiltrates (HP:0002113)2.38966673
64Spontaneous hematomas (HP:0007420)2.38914673
65Malnutrition (HP:0004395)2.31957880
66Abnormality of B cell number (HP:0010975)2.31790732
67Central scotoma (HP:0000603)2.23314926
68B lymphocytopenia (HP:0010976)2.19677392
69Thyroiditis (HP:0100646)2.16394083
70Abnormality of purine metabolism (HP:0004352)2.13907366
71Hypochromic anemia (HP:0001931)2.13113454
72Prolonged bleeding time (HP:0003010)2.10532610
73Parakeratosis (HP:0001036)2.10278932
74Hypochromic microcytic anemia (HP:0004840)2.09897207
75Asplenia (HP:0001746)2.09794600
76Keratitis (HP:0000491)2.05825928
77Basal cell carcinoma (HP:0002671)2.03308479
78Progressive external ophthalmoplegia (HP:0000590)2.01740706
79Joint swelling (HP:0001386)1.98071405
80Hemoptysis (HP:0002105)1.97018831
81Hypergammaglobulinemia (HP:0010702)1.95209825
82Gangrene (HP:0100758)1.93037986
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.92702400
84Pulmonary embolism (HP:0002204)1.88091634
85Urticaria (HP:0001025)1.86910991
86Centrally nucleated skeletal muscle fibers (HP:0003687)1.85691499
87Gingivitis (HP:0000230)1.82781138
88Abnormality of male internal genitalia (HP:0000022)1.81500064
89Amaurosis fugax (HP:0100576)1.78741535
90Hypoproteinemia (HP:0003075)1.77550735
91Congenital stationary night blindness (HP:0007642)1.77004999
92Acute hepatic failure (HP:0006554)1.73347387
93Global brain atrophy (HP:0002283)1.72995602
94Recurrent lower respiratory tract infections (HP:0002783)1.70447166
95Arterial thrombosis (HP:0004420)1.70264802
96Neutropenia (HP:0001875)1.70227046
97Inflammation of the large intestine (HP:0002037)1.70074597
98Papilledema (HP:0001085)1.66968850
99Recurrent sinusitis (HP:0011108)1.66771718
100Teleangiectasia of the skin (HP:0100585)1.64763637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.82839901
2TXK5.74091701
3ZAP702.88685406
4TAOK32.79553671
5KDR2.78113097
6MAP3K112.71670040
7FES2.54672986
8TESK22.28590858
9ITK2.28243378
10PASK2.26793259
11BTK2.24259510
12IKBKE2.15773278
13RIPK42.13670159
14GRK62.11399104
15MAP3K122.11094140
16CSK2.00167443
17EPHB11.76042590
18TBK11.74437567
19LCK1.66184947
20IKBKB1.63996361
21BMPR21.61886654
22CAMKK11.60378157
23CAMKK21.54993382
24SYK1.54122483
25MAP3K141.51826064
26JAK31.51237870
27MAP3K131.48937409
28TNK21.44549768
29EPHA31.34297543
30TEC1.34089250
31TYK21.33873722
32PRPF4B1.33580445
33HCK1.29304121
34BLK1.26739668
35NLK1.19400296
36LYN1.18378407
37JAK11.09601487
38IRAK41.09594059
39NEK11.08132367
40FGFR41.04136374
41MARK31.03450147
42MAP3K10.98869725
43CDK120.95871265
44STK100.93852028
45PRKCQ0.87661933
46PIM10.86644723
47JAK20.81643311
48MAPK150.76328041
49LRRK20.73160799
50HIPK20.71168421
51GRK70.70516577
52FGFR30.67489413
53PKN20.65470095
54PTK60.65430925
55SIK30.64107997
56TAOK10.62646790
57STK160.61396808
58CSF1R0.61390848
59MAP2K30.59608254
60PDK10.55166938
61MAP3K50.52611532
62GRK50.51402163
63FYN0.51285229
64MAPK70.50837919
65FGR0.49392594
66TAOK20.48823463
67TYRO30.46836096
68RPS6KB10.44520990
69MAPK120.44120330
70TGFBR20.43780154
71SCYL20.41176431
72TRIB30.40592158
73BRD40.40409774
74PRKD20.39459429
75MAP3K30.37883020
76CDK190.34162202
77TESK10.33562711
78PRKCH0.31333701
79CLK10.30771307
80IRAK10.29222720
81MAPK30.28536081
82MAP2K20.27938233
83MAPK110.26822962
84IGF1R0.26551562
85MAPKAPK20.26000462
86GSK3A0.25043576
87PDGFRB0.24414685
88ADRBK20.24035932
89TRPM70.22814125
90MAP3K70.22435713
91CAMK2D0.18539121
92PRKCD0.18444649
93CDK40.18100023
94RPS6KC10.17723110
95RPS6KL10.17723110
96SMG10.17577128
97WNK10.17312828
98CHUK0.17105385
99ERN10.16333326
100MYLK0.16179615

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.17387678
2T cell receptor signaling pathway_Homo sapiens_hsa046603.70782037
3Allograft rejection_Homo sapiens_hsa053302.93486595
4Autoimmune thyroid disease_Homo sapiens_hsa053202.92534744
5Graft-versus-host disease_Homo sapiens_hsa053322.79151665
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.64311010
7Measles_Homo sapiens_hsa051622.58356956
8Hematopoietic cell lineage_Homo sapiens_hsa046402.46180521
9Antigen processing and presentation_Homo sapiens_hsa046122.33054816
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.24770051
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23788718
12Type I diabetes mellitus_Homo sapiens_hsa049402.10686587
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07729456
14Osteoclast differentiation_Homo sapiens_hsa043802.06217309
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.01977626
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91579523
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90047043
18B cell receptor signaling pathway_Homo sapiens_hsa046621.74739002
19Herpes simplex infection_Homo sapiens_hsa051681.70989243
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68766102
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.67566009
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63613600
23Viral myocarditis_Homo sapiens_hsa054161.62956184
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.61974677
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56529196
26Leishmaniasis_Homo sapiens_hsa051401.54605551
27Acute myeloid leukemia_Homo sapiens_hsa052211.43472811
28Chemokine signaling pathway_Homo sapiens_hsa040621.39391452
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.39214905
30TNF signaling pathway_Homo sapiens_hsa046681.29888793
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27559981
32Viral carcinogenesis_Homo sapiens_hsa052031.25644233
33Proteasome_Homo sapiens_hsa030501.23322059
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20187469
35Ribosome_Homo sapiens_hsa030101.19721885
36Malaria_Homo sapiens_hsa051441.19477849
37Hepatitis B_Homo sapiens_hsa051611.13866842
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11062140
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09102586
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08972861
41HTLV-I infection_Homo sapiens_hsa051661.07508437
42Influenza A_Homo sapiens_hsa051641.02398059
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95707908
44Legionellosis_Homo sapiens_hsa051340.92238329
45Staphylococcus aureus infection_Homo sapiens_hsa051500.91712362
46Asthma_Homo sapiens_hsa053100.90000146
47Phototransduction_Homo sapiens_hsa047440.89363054
48Spliceosome_Homo sapiens_hsa030400.86821347
49Tuberculosis_Homo sapiens_hsa051520.85884446
50Apoptosis_Homo sapiens_hsa042100.84648480
51Epstein-Barr virus infection_Homo sapiens_hsa051690.82842119
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.82615447
53Pertussis_Homo sapiens_hsa051330.80415651
54Shigellosis_Homo sapiens_hsa051310.79462207
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79077402
56Toxoplasmosis_Homo sapiens_hsa051450.73286443
57VEGF signaling pathway_Homo sapiens_hsa043700.72149688
58Hepatitis C_Homo sapiens_hsa051600.71011068
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68131640
60African trypanosomiasis_Homo sapiens_hsa051430.66433647
61Rheumatoid arthritis_Homo sapiens_hsa053230.65686711
62FoxO signaling pathway_Homo sapiens_hsa040680.57791329
63Prolactin signaling pathway_Homo sapiens_hsa049170.57762216
64Platelet activation_Homo sapiens_hsa046110.56446276
65Non-small cell lung cancer_Homo sapiens_hsa052230.56336644
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54569619
67Pancreatic cancer_Homo sapiens_hsa052120.49911441
68Regulation of autophagy_Homo sapiens_hsa041400.48172739
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47606859
70MAPK signaling pathway_Homo sapiens_hsa040100.47549684
71N-Glycan biosynthesis_Homo sapiens_hsa005100.39805007
72Endocytosis_Homo sapiens_hsa041440.39722123
73Chronic myeloid leukemia_Homo sapiens_hsa052200.37861428
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.36923020
75Colorectal cancer_Homo sapiens_hsa052100.33472816
76Fanconi anemia pathway_Homo sapiens_hsa034600.32016047
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31119395
78Salmonella infection_Homo sapiens_hsa051320.30081882
79Renal cell carcinoma_Homo sapiens_hsa052110.29735049
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29597952
81RNA degradation_Homo sapiens_hsa030180.29569305
82mRNA surveillance pathway_Homo sapiens_hsa030150.28909817
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.28313305
84Homologous recombination_Homo sapiens_hsa034400.27506019
85Parkinsons disease_Homo sapiens_hsa050120.26789326
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.25467795
87Ras signaling pathway_Homo sapiens_hsa040140.24921401
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23805859
89Phagosome_Homo sapiens_hsa041450.22096890
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20197511
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18640919
92Mineral absorption_Homo sapiens_hsa049780.17287749
93Oxidative phosphorylation_Homo sapiens_hsa001900.17112312
94Dorso-ventral axis formation_Homo sapiens_hsa043200.16954219
95Rap1 signaling pathway_Homo sapiens_hsa040150.16542676
96Alzheimers disease_Homo sapiens_hsa050100.15987775
97Systemic lupus erythematosus_Homo sapiens_hsa053220.15493852
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13929506
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12798637
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12471016

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