TRAV21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.08310139
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.44322142
3negative regulation of cell killing (GO:0031342)7.20046327
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.20046327
5negative thymic T cell selection (GO:0045060)7.14981408
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.08389722
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.87264932
8positive regulation of gamma-delta T cell activation (GO:0046645)6.64867590
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.34160958
10antigen processing and presentation of endogenous antigen (GO:0019883)6.09300885
11regulation of B cell receptor signaling pathway (GO:0050855)5.95063721
12positive T cell selection (GO:0043368)5.90516235
13cellular response to interleukin-15 (GO:0071350)5.87046828
14response to interleukin-15 (GO:0070672)5.65810884
15tolerance induction (GO:0002507)5.50121659
16T cell migration (GO:0072678)5.47712683
17leukocyte aggregation (GO:0070486)5.44097354
18regulation of gamma-delta T cell differentiation (GO:0045586)5.43731039
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.41715972
20thymic T cell selection (GO:0045061)5.41411529
21regulation of regulatory T cell differentiation (GO:0045589)5.38363747
22positive thymic T cell selection (GO:0045059)5.28668052
23T cell selection (GO:0045058)5.27427433
24regulation of T cell tolerance induction (GO:0002664)5.09306741
25regulation of gamma-delta T cell activation (GO:0046643)5.03329576
26positive regulation of granulocyte differentiation (GO:0030854)4.93783905
27T cell receptor signaling pathway (GO:0050852)4.81262710
28negative regulation of T cell mediated immunity (GO:0002710)4.76185297
29regulation of isotype switching to IgG isotypes (GO:0048302)4.67315850
30positive regulation of tolerance induction (GO:0002645)4.56291449
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.45513496
32positive regulation of B cell differentiation (GO:0045579)4.40401619
33regulation of tolerance induction (GO:0002643)4.31674643
34regulation of alpha-beta T cell proliferation (GO:0046640)4.31224805
35regulation of interleukin-2 biosynthetic process (GO:0045076)4.29203403
36antigen receptor-mediated signaling pathway (GO:0050851)4.28039986
37mast cell activation (GO:0045576)4.22380274
38positive regulation of T cell differentiation in thymus (GO:0033089)4.18446731
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.16654397
40positive regulation of alpha-beta T cell proliferation (GO:0046641)4.11359181
41regulation of B cell differentiation (GO:0045577)4.09148992
42positive regulation of interleukin-4 production (GO:0032753)4.03757455
43regulation of T cell mediated cytotoxicity (GO:0001914)3.97324373
44interferon-gamma production (GO:0032609)3.97168703
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.87618512
46regulation of natural killer cell mediated immunity (GO:0002715)3.85968239
47regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.85968239
48negative regulation of leukocyte mediated immunity (GO:0002704)3.84877503
49T cell costimulation (GO:0031295)3.80758060
50lymphocyte costimulation (GO:0031294)3.76189587
51antigen processing and presentation via MHC class Ib (GO:0002475)3.73482233
52negative regulation of T cell apoptotic process (GO:0070233)3.72916339
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.69533486
54regulation of T cell receptor signaling pathway (GO:0050856)3.66163555
55regulation of interleukin-4 production (GO:0032673)3.65965640
56negative regulation of interleukin-12 production (GO:0032695)3.64982345
57regulation of defense response to virus by virus (GO:0050690)3.55627584
58regulation of leukocyte mediated cytotoxicity (GO:0001910)3.53641469
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.49132333
60alpha-beta T cell differentiation (GO:0046632)3.46947284
61immunoglobulin mediated immune response (GO:0016064)3.46603586
62activated T cell proliferation (GO:0050798)3.45804840
63T cell homeostasis (GO:0043029)3.41149111
64lymphocyte migration (GO:0072676)3.38202550
65respiratory burst (GO:0045730)3.37640601
66negative regulation of stress fiber assembly (GO:0051497)3.36516828
67regulation of granulocyte differentiation (GO:0030852)3.36273817
68positive regulation of humoral immune response (GO:0002922)3.34055408
69positive regulation of interleukin-2 production (GO:0032743)3.30158295
70type I interferon signaling pathway (GO:0060337)3.28877468
71cellular response to type I interferon (GO:0071357)3.28877468
72response to type I interferon (GO:0034340)3.25483057
73T cell differentiation (GO:0030217)3.25334210
74mast cell activation involved in immune response (GO:0002279)3.24535853
75mast cell degranulation (GO:0043303)3.24535853
76regulation of alpha-beta T cell activation (GO:0046634)3.23365183
77Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23295744
78regulation of cell killing (GO:0031341)3.23099659
79positive regulation of natural killer cell mediated immunity (GO:0002717)3.22419171
80B cell receptor signaling pathway (GO:0050853)3.17385281
81negative regulation of phagocytosis (GO:0050765)3.16994575
82positive regulation of cell killing (GO:0031343)3.15225031
83B cell mediated immunity (GO:0019724)3.13274929
84positive regulation of alpha-beta T cell activation (GO:0046635)3.12246590
85negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11928916
86positive regulation of T cell mediated immunity (GO:0002711)3.09891034
87alpha-beta T cell activation (GO:0046631)3.09305389
88detection of bacterium (GO:0016045)3.07767299
89leukocyte degranulation (GO:0043299)3.06835082
90regulation of T cell mediated immunity (GO:0002709)3.01151822
91immune response-activating cell surface receptor signaling pathway (GO:0002429)3.00218933
92detection of other organism (GO:0098543)2.99812912
93negative regulation of adaptive immune response (GO:0002820)2.94313457
94negative regulation of immunoglobulin mediated immune response (GO:0002890)2.93678359
95negative regulation of B cell mediated immunity (GO:0002713)2.93678359
96regulation of T cell apoptotic process (GO:0070232)2.91997266
97positive regulation of isotype switching (GO:0045830)2.90413115
98CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.90139288
99T-helper cell differentiation (GO:0042093)2.90139288
100chemokine-mediated signaling pathway (GO:0070098)2.88796532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.76775458
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.67880384
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.19568888
4RUNX_20019798_ChIP-Seq_JUKART_Human4.19482296
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.86213714
6MYB_26560356_Chip-Seq_TH2_Human3.79084585
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.70711443
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.62720404
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.55398980
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.42070200
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32088241
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.06373695
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04044245
14MYB_26560356_Chip-Seq_TH1_Human2.95660092
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.93861736
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.91493448
17UTX_26944678_Chip-Seq_JUKART_Human2.89832415
18MAF_26560356_Chip-Seq_TH1_Human2.88261604
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70044784
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59998405
21GATA3_27048872_Chip-Seq_THYMUS_Human2.53835576
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.46449781
23MAF_26560356_Chip-Seq_TH2_Human2.45762079
24SPI1_23547873_ChIP-Seq_NB4_Human2.29768516
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25067646
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.17331692
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16584606
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94288633
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93120260
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91884929
31MYC_22102868_ChIP-Seq_BL_Human1.90263819
32GATA3_26560356_Chip-Seq_TH2_Human1.90117208
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.76703100
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.76561092
35SPI1_23127762_ChIP-Seq_K562_Human1.74335692
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73577147
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71437768
38VDR_21846776_ChIP-Seq_THP-1_Human1.70193615
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69819337
40VDR_24763502_ChIP-Seq_THP-1_Human1.69251238
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.58065818
42SCL_19346495_ChIP-Seq_HPC-7_Human1.54501076
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51229362
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48184204
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47498861
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43143387
47TCF7_22412390_ChIP-Seq_EML_Mouse1.27530058
48CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20968202
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20329922
50CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20078299
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18260719
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18233092
53VDR_23849224_ChIP-Seq_CD4+_Human1.16222143
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16043152
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14763293
56KDM2B_26808549_Chip-Seq_DND41_Human1.14658735
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14507381
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14383295
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13503702
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13053548
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11726329
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.11518399
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09102523
64PU_27001747_Chip-Seq_BMDM_Mouse1.06901781
65CIITA_25753668_ChIP-Seq_RAJI_Human1.05795670
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04788562
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04275981
68VDR_24787735_ChIP-Seq_THP-1_Human0.95381565
69SPI1_20517297_ChIP-Seq_HL60_Human0.95250811
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95016233
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94992372
72FOXP3_21729870_ChIP-Seq_TREG_Human0.94665504
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94369472
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91913364
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91720957
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91219100
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90284634
78GATA1_19941827_ChIP-Seq_MEL_Mouse0.88783386
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87314067
80BCL6_27268052_Chip-Seq_Bcells_Human0.86830940
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86384694
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85649571
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84335690
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83520801
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81963729
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.81862660
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81032637
88FLI1_27457419_Chip-Seq_LIVER_Mouse0.79396639
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78373138
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77813994
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77009507
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76359766
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76355956
94GATA3_26560356_Chip-Seq_TH1_Human0.74356293
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74276541
96ETS1_21867929_ChIP-Seq_TH2_Mouse0.72432185
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71293408
98BCOR_27268052_Chip-Seq_Bcells_Human0.71284873
99P300_27268052_Chip-Seq_Bcells_Human0.71075103
100SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.69482050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.01828658
2MP0003763_abnormal_thymus_physiology4.98428648
3MP0001835_abnormal_antigen_presentation3.63008692
4MP0003436_decreased_susceptibility_to3.53566652
5MP0003724_increased_susceptibility_to3.37891345
6MP0005000_abnormal_immune_tolerance3.28676910
7MP0001800_abnormal_humoral_immune3.18998128
8MP0009785_altered_susceptibility_to3.00985646
9MP0009333_abnormal_splenocyte_physiolog2.94689923
10MP0005025_abnormal_response_to2.87500539
11MP0002420_abnormal_adaptive_immunity2.85049527
12MP0001819_abnormal_immune_cell2.79298149
13MP0002723_abnormal_immune_serum2.78293016
14MP0000685_abnormal_immune_system2.74089523
15MP0005387_immune_system_phenotype2.59899128
16MP0001790_abnormal_immune_system2.59899128
17MP0000703_abnormal_thymus_morphology2.56681762
18MP0002452_abnormal_antigen_presenting2.53906191
19MP0003866_abnormal_defecation2.53619503
20MP0004381_abnormal_hair_follicle2.44775526
21MP0002419_abnormal_innate_immunity2.40483469
22MP0002398_abnormal_bone_marrow2.38530802
23MP0001873_stomach_inflammation2.38487200
24MP0002405_respiratory_system_inflammati2.32333493
25MP0006082_CNS_inflammation2.28616252
26MP0002166_altered_tumor_susceptibility2.26655607
27MP0000716_abnormal_immune_system2.23996772
28MP0002148_abnormal_hypersensitivity_rea2.23572828
29MP0010155_abnormal_intestine_physiology2.11568213
30MP0000689_abnormal_spleen_morphology2.03944888
31MP0003300_gastrointestinal_ulcer2.02558664
32MP0002722_abnormal_immune_system1.98558426
33MP0000465_gastrointestinal_hemorrhage1.97088431
34MP0002009_preneoplasia1.93004105
35MP0005464_abnormal_platelet_physiology1.89355195
36MP0004947_skin_inflammation1.73071864
37MP0002429_abnormal_blood_cell1.72444032
38MP0002277_abnormal_respiratory_mucosa1.72046278
39MP0002933_joint_inflammation1.70000501
40MP0001845_abnormal_inflammatory_respons1.69894489
41MP0005075_abnormal_melanosome_morpholog1.68247569
42MP0003303_peritoneal_inflammation1.64132413
43MP0001533_abnormal_skeleton_physiology1.60080633
44MP0005377_hearing/vestibular/ear_phenot1.57748572
45MP0003878_abnormal_ear_physiology1.57748572
46MP0002006_tumorigenesis1.56619512
47MP0005310_abnormal_salivary_gland1.47578025
48MP0003646_muscle_fatigue1.40520805
49MP0002396_abnormal_hematopoietic_system1.17657923
50MP0008469_abnormal_protein_level1.17025062
51MP0002163_abnormal_gland_morphology1.14117737
52MP0001851_eye_inflammation1.12881517
53MP0008260_abnormal_autophagy1.12143272
54MP0000858_altered_metastatic_potential1.10966259
55MP0003448_altered_tumor_morphology1.07658706
56MP0001348_abnormal_lacrimal_gland1.06536062
57MP0000490_abnormal_crypts_of1.06242240
58MP0009764_decreased_sensitivity_to1.05853318
59MP0004130_abnormal_muscle_cell1.00228685
60MP0002132_abnormal_respiratory_system0.98882565
61MP0003045_fibrosis0.98058582
62MP0001853_heart_inflammation0.97710714
63MP0003172_abnormal_lysosome_physiology0.92873272
64MP0002693_abnormal_pancreas_physiology0.90079127
65MP0001663_abnormal_digestive_system0.81077521
66MP0005166_decreased_susceptibility_to0.79933651
67MP0002998_abnormal_bone_remodeling0.79286836
68MP0009763_increased_sensitivity_to0.76998031
69MP0000015_abnormal_ear_pigmentation0.73392369
70MP0002019_abnormal_tumor_incidence0.70739223
71MP0003075_altered_response_to0.69766636
72MP0005645_abnormal_hypothalamus_physiol0.68309958
73MP0001919_abnormal_reproductive_system0.68016812
74MP0003690_abnormal_glial_cell0.59832304
75MP0004185_abnormal_adipocyte_glucose0.59189601
76MP0004883_abnormal_blood_vessel0.56944178
77MP0004510_myositis0.55429925
78MP0003183_abnormal_peptide_metabolism0.55256496
79MP0001542_abnormal_bone_strength0.55245464
80MP0001765_abnormal_ion_homeostasis0.53272594
81MP0005390_skeleton_phenotype0.52925079
82MP0002138_abnormal_hepatobiliary_system0.52893622
83MP0008961_abnormal_basal_metabolism0.47542300
84MP0002136_abnormal_kidney_physiology0.47514503
85MP0000249_abnormal_blood_vessel0.46477187
86MP0003795_abnormal_bone_structure0.45960059
87MP0003828_pulmonary_edema0.45891908
88MP0005379_endocrine/exocrine_gland_phen0.45674382
89MP0001243_abnormal_dermal_layer0.44495493
90MP0008874_decreased_physiological_sensi0.43954346
91MP0003191_abnormal_cellular_cholesterol0.43901701
92MP0001986_abnormal_taste_sensitivity0.43382846
93MP0003252_abnormal_bile_duct0.42250373
94MP0003806_abnormal_nucleotide_metabolis0.40856547
95MP0000604_amyloidosis0.40096221
96MP0000920_abnormal_myelination0.38934262
97MP0005381_digestive/alimentary_phenotyp0.37681698
98MP0009642_abnormal_blood_homeostasis0.37360337
99MP0008569_lethality_at_weaning0.36298363
100MP0009765_abnormal_xenobiotic_induced0.35416723

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.49494958
2T lymphocytopenia (HP:0005403)6.41117675
3Abnormality of T cell number (HP:0011839)5.94193586
4Eczematoid dermatitis (HP:0000976)5.94192256
5Autoimmune hemolytic anemia (HP:0001890)5.91802703
6Stomatitis (HP:0010280)5.85932714
7Severe combined immunodeficiency (HP:0004430)5.21452635
8Abnormality of T cells (HP:0002843)5.09918390
9Myositis (HP:0100614)4.97626307
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.96661090
11Panhypogammaglobulinemia (HP:0003139)4.78220774
12Abnormality of macrophages (HP:0004311)4.55104552
13Optic neuritis (HP:0100653)4.54869452
14Retrobulbar optic neuritis (HP:0100654)4.54869452
15Orchitis (HP:0100796)4.31625282
16Recurrent fungal infections (HP:0002841)4.22169672
17Combined immunodeficiency (HP:0005387)4.18191649
18Recurrent cutaneous fungal infections (HP:0011370)3.96776311
19Chronic mucocutaneous candidiasis (HP:0002728)3.96776311
20Encephalitis (HP:0002383)3.93114075
21Aplastic anemia (HP:0001915)3.91763595
22Abnormality of T cell physiology (HP:0011840)3.91353901
23Gastrointestinal infarctions (HP:0005244)3.74017368
24IgG deficiency (HP:0004315)3.70338025
25Meningitis (HP:0001287)3.61495111
26Recurrent bacterial skin infections (HP:0005406)3.61424092
27Recurrent abscess formation (HP:0002722)3.60676979
28Autoimmune thrombocytopenia (HP:0001973)3.60310720
29Recurrent viral infections (HP:0004429)3.57840068
30Chronic diarrhea (HP:0002028)3.51728928
31Vasculitis (HP:0002633)3.51489621
32Lymphopenia (HP:0001888)3.49614180
33Keratoconjunctivitis sicca (HP:0001097)3.48314551
34Chronic obstructive pulmonary disease (HP:0006510)3.38369523
35Obstructive lung disease (HP:0006536)3.38369523
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.27923342
37Abnormality of eosinophils (HP:0001879)3.25347747
38Inflammation of the large intestine (HP:0002037)3.24576567
39Spontaneous hematomas (HP:0007420)3.22396749
40Keratoconjunctivitis (HP:0001096)3.22091219
41Leukocytosis (HP:0001974)3.21467289
42Recurrent skin infections (HP:0001581)3.19551843
43Pulmonary infiltrates (HP:0002113)3.16911376
44Gastrointestinal inflammation (HP:0004386)3.14762844
45IgM deficiency (HP:0002850)3.06980581
46Increased IgM level (HP:0003496)3.04360830
47Mediastinal lymphadenopathy (HP:0100721)3.03445021
48Increased IgE level (HP:0003212)3.03147181
49Hypochromic microcytic anemia (HP:0004840)3.00585918
50Recurrent bronchitis (HP:0002837)2.97965092
51Thyroiditis (HP:0100646)2.96146591
52Pustule (HP:0200039)2.79315216
53Eosinophilia (HP:0001880)2.77877072
54Agammaglobulinemia (HP:0004432)2.76879037
55Hypochromic anemia (HP:0001931)2.75622163
56Hemoptysis (HP:0002105)2.73143529
57Granulocytopenia (HP:0001913)2.69512077
58Chest pain (HP:0100749)2.68654485
59Recurrent gram-negative bacterial infections (HP:0005420)2.67738579
60Prolonged bleeding time (HP:0003010)2.61583669
61Microcytic anemia (HP:0001935)2.56385123
62Lymphoma (HP:0002665)2.54448990
63Pulmonary embolism (HP:0002204)2.53550425
64Urticaria (HP:0001025)2.50913090
65Joint swelling (HP:0001386)2.50049520
66Gangrene (HP:0100758)2.49194290
67Hypergammaglobulinemia (HP:0010702)2.47198256
68Hypoproteinemia (HP:0003075)2.37858693
69Anorexia (HP:0002039)2.37532629
70Colitis (HP:0002583)2.33632903
71Hyperlipoproteinemia (HP:0010980)2.24000621
72Abnormality of B cell number (HP:0010975)2.23792266
73Epistaxis (HP:0000421)2.21553365
74Pigmentary retinal degeneration (HP:0001146)2.20681425
75Gingival bleeding (HP:0000225)2.17340185
76Slow saccadic eye movements (HP:0000514)2.11464283
77Glomerulopathy (HP:0100820)2.05641471
78B lymphocytopenia (HP:0010976)2.02909393
79Gingivitis (HP:0000230)2.01103198
80Arterial thrombosis (HP:0004420)2.00415128
81Hypoplasia of the thymus (HP:0000778)1.99963937
82Abnormality of the pleura (HP:0002103)1.99508318
83Episodic fever (HP:0001954)1.96944173
84Verrucae (HP:0200043)1.96416183
85Papilloma (HP:0012740)1.96416183
86Recurrent sinusitis (HP:0011108)1.95813155
87Sepsis (HP:0100806)1.95038494
88Petechiae (HP:0000967)1.90440027
89Viral hepatitis (HP:0006562)1.89747965
90Bronchitis (HP:0012387)1.88035794
91Neutropenia (HP:0001875)1.81848653
92Abnormality of the pericardium (HP:0001697)1.80278966
93Keratitis (HP:0000491)1.80131340
94Recurrent otitis media (HP:0000403)1.77526884
95Acute hepatic failure (HP:0006554)1.76979056
96Tetany (HP:0001281)1.75699472
97Acne (HP:0001061)1.74938317
98Villous atrophy (HP:0011473)1.73246363
99Abnormality of small intestinal villus morphology (HP:0011472)1.73246363
100Skin rash (HP:0000988)1.72813743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.31650269
2MAP4K14.58771025
3TESK23.58011227
4PASK3.33974888
5ZAP702.84320986
6ITK2.63304331
7RIPK42.49639171
8FES2.41678688
9BTK2.32558408
10CSK2.29795344
11NLK2.25097176
12GRK62.07213648
13TAOK32.05283711
14MAP3K121.96658931
15MST41.94396985
16KDR1.92597249
17TEC1.84296192
18SYK1.81759196
19MAP3K111.81332687
20TYK21.80589482
21MAP2K31.77953158
22JAK31.77395076
23LCK1.76516028
24IRAK41.74050399
25SCYL21.73065894
26TNK21.71778556
27CAMKK11.67532185
28HCK1.52239056
29IKBKE1.50689337
30MAP3K31.43145025
31JAK11.37224529
32LYN1.35250677
33PRPF4B1.18483780
34PRKCQ1.18446781
35CLK11.14185311
36RPS6KA41.12591675
37BLK1.10824847
38EPHB11.09691608
39CSF1R1.07451082
40TAOK11.01878545
41CAMKK20.96655829
42STK100.95968179
43SIK30.92620385
44DYRK1B0.90013564
45LRRK20.88216118
46TESK10.87761052
47TAOK20.86336048
48CDK190.85699600
49YES10.85564610
50MAP3K100.84768300
51TBK10.83746881
52PIM10.83098139
53FYN0.77844869
54MAP3K130.71362297
55FGR0.69430507
56MARK30.68084876
57MAP3K10.68075737
58PDK10.66972180
59JAK20.66692520
60MAP2K60.66241910
61FGFR40.64603177
62IKBKB0.62631821
63PTK60.58601489
64HIPK20.48742433
65UHMK10.48594813
66MAP3K140.45949430
67MAPKAPK30.44860092
68GRK70.44405730
69FGFR30.43962653
70MAP3K50.43762550
71CDK60.41754644
72MAP3K70.40878808
73KIT0.40200624
74NEK60.40049433
75PRKCH0.38510282
76STK380.36033604
77SGK20.34486584
78RPS6KA50.34024293
79CDK120.33652446
80STK110.30846312
81IGF1R0.30336868
82CDK30.30026332
83SGK30.29538258
84PDGFRB0.28980159
85MAPKAPK20.27651095
86INSR0.26979245
87EPHA30.26613291
88ERN10.26079638
89CDK40.25062499
90MAPK110.24764054
91SGK2230.23631917
92SGK4940.23631917
93PIK3CG0.22857909
94RPS6KL10.22635886
95RPS6KC10.22635886
96RPS6KA60.22574435
97CAMK10.22437662
98MAPK120.22104402
99SGK10.19865018
100PTK2B0.18732683

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.88101782
2T cell receptor signaling pathway_Homo sapiens_hsa046603.89556435
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.45200286
4Autoimmune thyroid disease_Homo sapiens_hsa053203.08968581
5Graft-versus-host disease_Homo sapiens_hsa053323.01761294
6Allograft rejection_Homo sapiens_hsa053303.01644217
7Antigen processing and presentation_Homo sapiens_hsa046122.57878094
8Hematopoietic cell lineage_Homo sapiens_hsa046402.46036150
9Measles_Homo sapiens_hsa051622.43927677
10Type I diabetes mellitus_Homo sapiens_hsa049402.28669857
11Osteoclast differentiation_Homo sapiens_hsa043802.27321977
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24630441
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.20786071
14Malaria_Homo sapiens_hsa051442.14040338
15B cell receptor signaling pathway_Homo sapiens_hsa046621.87217354
16Viral myocarditis_Homo sapiens_hsa054161.81031905
17Leishmaniasis_Homo sapiens_hsa051401.74112374
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66523488
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66061572
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.62739311
21Staphylococcus aureus infection_Homo sapiens_hsa051501.58123523
22Chemokine signaling pathway_Homo sapiens_hsa040621.52649359
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.45946208
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45454779
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40618947
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39957963
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36978412
28Tuberculosis_Homo sapiens_hsa051521.35775664
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32412705
30Herpes simplex infection_Homo sapiens_hsa051681.31050494
31Acute myeloid leukemia_Homo sapiens_hsa052211.30887163
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.25777271
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25621078
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24126787
35Shigellosis_Homo sapiens_hsa051311.16245627
36TNF signaling pathway_Homo sapiens_hsa046681.15772430
37Hepatitis B_Homo sapiens_hsa051611.02060183
38Legionellosis_Homo sapiens_hsa051340.99931465
39Other glycan degradation_Homo sapiens_hsa005110.94760225
40Ribosome_Homo sapiens_hsa030100.94524777
41Influenza A_Homo sapiens_hsa051640.91911727
42Toxoplasmosis_Homo sapiens_hsa051450.91895462
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88475392
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86297820
45Platelet activation_Homo sapiens_hsa046110.85771328
46HTLV-I infection_Homo sapiens_hsa051660.83561807
47Non-small cell lung cancer_Homo sapiens_hsa052230.81311788
48Viral carcinogenesis_Homo sapiens_hsa052030.80636894
49Asthma_Homo sapiens_hsa053100.78139163
50Rheumatoid arthritis_Homo sapiens_hsa053230.77728075
51Endocytosis_Homo sapiens_hsa041440.76413790
52Epstein-Barr virus infection_Homo sapiens_hsa051690.76290759
53Proteasome_Homo sapiens_hsa030500.74575793
54African trypanosomiasis_Homo sapiens_hsa051430.73488640
55Phagosome_Homo sapiens_hsa041450.70402228
56Salmonella infection_Homo sapiens_hsa051320.69884954
57Apoptosis_Homo sapiens_hsa042100.69541941
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69170300
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66012584
60VEGF signaling pathway_Homo sapiens_hsa043700.65184152
61Pertussis_Homo sapiens_hsa051330.64426438
62Hepatitis C_Homo sapiens_hsa051600.59848789
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59804522
64FoxO signaling pathway_Homo sapiens_hsa040680.59144742
65Pancreatic cancer_Homo sapiens_hsa052120.58152577
66Colorectal cancer_Homo sapiens_hsa052100.56704737
67Regulation of autophagy_Homo sapiens_hsa041400.53178641
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53056685
69MAPK signaling pathway_Homo sapiens_hsa040100.50144033
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41010031
71Thyroid cancer_Homo sapiens_hsa052160.40753603
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40338227
73Inositol phosphate metabolism_Homo sapiens_hsa005620.37437607
74Endometrial cancer_Homo sapiens_hsa052130.36981799
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33554261
76Ras signaling pathway_Homo sapiens_hsa040140.32818518
77Chronic myeloid leukemia_Homo sapiens_hsa052200.31971549
78Notch signaling pathway_Homo sapiens_hsa043300.31488542
79Rap1 signaling pathway_Homo sapiens_hsa040150.31471225
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31414786
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30898700
82Long-term potentiation_Homo sapiens_hsa047200.29978930
83Prolactin signaling pathway_Homo sapiens_hsa049170.29214890
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.28462310
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.28299818
86Renin secretion_Homo sapiens_hsa049240.28193063
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26570710
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26303001
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25683867
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.23518235
91Olfactory transduction_Homo sapiens_hsa047400.21268064
92Insulin resistance_Homo sapiens_hsa049310.20117728
93Prostate cancer_Homo sapiens_hsa052150.19354973
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17455727
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16834499
96Renal cell carcinoma_Homo sapiens_hsa052110.14843550
97Collecting duct acid secretion_Homo sapiens_hsa049660.13368720
98Choline metabolism in cancer_Homo sapiens_hsa052310.13209403
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10425351
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09975815

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