TRAV22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)5.69368753
2positive regulation of protein homodimerization activity (GO:0090073)5.08260174
3regulation of T cell chemotaxis (GO:0010819)4.92563043
4positive regulation of T cell chemotaxis (GO:0010820)4.92563043
5germinal center formation (GO:0002467)4.86409435
6T cell migration (GO:0072678)4.84971605
7cellular response to interleukin-15 (GO:0071350)4.74702480
8positive regulation of gamma-delta T cell activation (GO:0046645)4.71889753
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.66335542
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.61112928
11response to interleukin-15 (GO:0070672)4.60670915
12ribosome assembly (GO:0042255)4.52333877
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.42730503
14cellular response to arsenic-containing substance (GO:0071243)4.42303317
15regulation of interleukin-2 biosynthetic process (GO:0045076)4.34207932
16antigen processing and presentation of endogenous antigen (GO:0019883)4.33822519
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33814458
18negative regulation of cell killing (GO:0031342)4.33814458
19regulation of germinal center formation (GO:0002634)4.33753668
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.28746314
21negative T cell selection (GO:0043383)4.26630862
22positive regulation of alpha-beta T cell proliferation (GO:0046641)4.21817887
23negative thymic T cell selection (GO:0045060)4.20546117
24segment specification (GO:0007379)4.18096756
25regulation of isotype switching to IgG isotypes (GO:0048302)4.14765271
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.09108936
27regulation of alpha-beta T cell proliferation (GO:0046640)4.08358992
28monoubiquitinated protein deubiquitination (GO:0035520)4.07371702
29ncRNA catabolic process (GO:0034661)4.01517546
30tolerance induction (GO:0002507)3.98084692
31regulation of B cell receptor signaling pathway (GO:0050855)3.91809740
32definitive hemopoiesis (GO:0060216)3.90634407
33positive regulation of translational initiation (GO:0045948)3.85583658
34regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.85182642
35histone H3-K9 demethylation (GO:0033169)3.81294523
36regulation of sarcomere organization (GO:0060297)3.78052378
37stress granule assembly (GO:0034063)3.74091362
38regulation of gamma-delta T cell differentiation (GO:0045586)3.66177603
39alpha-beta T cell differentiation involved in immune response (GO:0002293)3.61411890
40alpha-beta T cell activation involved in immune response (GO:0002287)3.61411890
41T cell differentiation involved in immune response (GO:0002292)3.61411890
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.61279131
43positive regulation of T cell migration (GO:2000406)3.60093274
44regulation of regulatory T cell differentiation (GO:0045589)3.58457235
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.50978098
46regulation of natural killer cell mediated immunity (GO:0002715)3.50978098
47positive regulation of tolerance induction (GO:0002645)3.50818836
48positive regulation of natural killer cell mediated immunity (GO:0002717)3.46829011
49response to vitamin E (GO:0033197)3.43723508
50positive regulation of granulocyte differentiation (GO:0030854)3.43238915
51defense response to protozoan (GO:0042832)3.40347653
52regulation of T cell tolerance induction (GO:0002664)3.40008615
53alpha-beta T cell differentiation (GO:0046632)3.39006875
54regulation of cytokine production involved in inflammatory response (GO:1900015)3.38471707
55interferon-gamma production (GO:0032609)3.36572381
56B cell receptor signaling pathway (GO:0050853)3.36030416
57CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.34892503
58T-helper cell differentiation (GO:0042093)3.34892503
59positive regulation of B cell differentiation (GO:0045579)3.34211301
60cytokine biosynthetic process (GO:0042089)3.34119651
61pentose-phosphate shunt (GO:0006098)3.33478774
62B cell homeostasis (GO:0001782)3.33111094
63regulation of gamma-delta T cell activation (GO:0046643)3.31913203
64regulation of lymphocyte chemotaxis (GO:1901623)3.29868752
65positive regulation of T cell differentiation in thymus (GO:0033089)3.29697060
66epithelial cell differentiation involved in kidney development (GO:0035850)3.26872314
67regulation of B cell differentiation (GO:0045577)3.26691503
68leukocyte aggregation (GO:0070486)3.25483098
69regulation of T cell migration (GO:2000404)3.24167103
70positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.22971161
71regulation of tolerance induction (GO:0002643)3.22855079
72positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21732928
73thymic T cell selection (GO:0045061)3.21281728
74regulation of T cell mediated cytotoxicity (GO:0001914)3.14520975
75negative regulation of T cell mediated immunity (GO:0002710)3.13448885
76positive thymic T cell selection (GO:0045059)3.13038690
77positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.12983640
78positive regulation of lymphocyte migration (GO:2000403)3.12946197
79purine nucleobase metabolic process (GO:0006144)3.09605420
80face development (GO:0060324)3.08356736
81ubiquinone biosynthetic process (GO:0006744)3.07390783
82lymphocyte migration (GO:0072676)3.04662969
83positive regulation of cell killing (GO:0031343)3.04164114
84actin nucleation (GO:0045010)3.03548395
85heart field specification (GO:0003128)3.03129729
86secondary heart field specification (GO:0003139)3.03129729
87antigen receptor-mediated signaling pathway (GO:0050851)3.02695015
88response to protozoan (GO:0001562)2.98629778
89regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97484760
90positive T cell selection (GO:0043368)2.96597331
91T cell receptor signaling pathway (GO:0050852)2.96299398
92mitochondrion distribution (GO:0048311)2.95189447
93alpha-beta T cell activation (GO:0046631)2.92500626
94lymphocyte chemotaxis (GO:0048247)2.92317962
95T cell selection (GO:0045058)2.91530464
96cardiac ventricle formation (GO:0003211)2.91434274
97NADPH regeneration (GO:0006740)2.87973034
98regulation of cell killing (GO:0031341)2.86662818
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86335590
100cartilage morphogenesis (GO:0060536)2.84960795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.49233889
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.59853221
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.49641186
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.39643936
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.69427257
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.64075402
7MYB_26560356_Chip-Seq_TH2_Human3.53822608
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.51562317
9E2F7_22180533_ChIP-Seq_HELA_Human3.43859941
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.26276264
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.14786468
12RUNX_20019798_ChIP-Seq_JUKART_Human3.14234557
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.11958453
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86047970
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.81541024
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.81478379
17MYB_26560356_Chip-Seq_TH1_Human2.80194695
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.65141717
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.42554507
20MAF_26560356_Chip-Seq_TH1_Human2.34628375
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.26324725
22SPI1_23547873_ChIP-Seq_NB4_Human2.21958705
23GATA3_27048872_Chip-Seq_THYMUS_Human2.15580068
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14610954
25MAF_26560356_Chip-Seq_TH2_Human2.09722280
26UTX_26944678_Chip-Seq_JUKART_Human1.95884408
27SCL_19346495_ChIP-Seq_HPC-7_Human1.94152877
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92769037
29MYC_22102868_ChIP-Seq_BL_Human1.90397559
30GATA3_26560356_Chip-Seq_TH2_Human1.84588002
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80400597
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.80273066
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76115666
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75201044
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66927336
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57304146
37VDR_24763502_ChIP-Seq_THP-1_Human1.52936116
38SPI1_23127762_ChIP-Seq_K562_Human1.52469953
39FOXP3_21729870_ChIP-Seq_TREG_Human1.51951487
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.50385022
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44669063
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40101423
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.39947792
44VDR_21846776_ChIP-Seq_THP-1_Human1.39476774
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38699292
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34229411
47TCF7_22412390_ChIP-Seq_EML_Mouse1.34194244
48ZNF274_21170338_ChIP-Seq_K562_Hela1.33860090
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29387089
50VDR_23849224_ChIP-Seq_CD4+_Human1.26651811
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21622812
52EGR1_19032775_ChIP-ChIP_M12_Human1.20912398
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19390480
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15862543
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.14967883
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13399267
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12740503
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11709826
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08411566
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08196029
61KDM2B_26808549_Chip-Seq_DND41_Human1.07707311
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00887214
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99657067
64HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98193461
65CEBPB_22108803_ChIP-Seq_LS180_Human0.96327631
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95603333
67ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94608107
68CTCF_26484167_Chip-Seq_Bcells_Mouse0.94381406
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93195755
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92019932
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91409443
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88663648
73SALL4_22934838_ChIP-ChIP_CD34+_Human0.88485735
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88109275
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87736047
76STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87648805
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85522907
78CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85102746
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84328886
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83813978
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83294339
82GATA3_26560356_Chip-Seq_TH1_Human0.82996883
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81765672
84AR_21572438_ChIP-Seq_LNCaP_Human0.81255429
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79952997
86STAT1_20625510_ChIP-Seq_HELA_Human0.76197736
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.75820945
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.73722580
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71969469
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.71865680
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71774251
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.70668272
93ETS1_21867929_ChIP-Seq_TH2_Mouse0.70267475
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69818623
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69328641
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69012545
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67314320
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.65664608
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64940109
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64109025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.99767592
2MP0009333_abnormal_splenocyte_physiolog4.64385719
3MP0005671_abnormal_response_to4.13421040
4MP0002009_preneoplasia3.68638329
5MP0001835_abnormal_antigen_presentation3.17284177
6MP0001873_stomach_inflammation3.01716108
7MP0008007_abnormal_cellular_replicative2.84267309
8MP0005000_abnormal_immune_tolerance2.83275432
9MP0005387_immune_system_phenotype2.81540468
10MP0001790_abnormal_immune_system2.81540468
11MP0001800_abnormal_humoral_immune2.81284598
12MP0009785_altered_susceptibility_to2.62719314
13MP0002166_altered_tumor_susceptibility2.51967176
14MP0000490_abnormal_crypts_of2.51023280
15MP0002405_respiratory_system_inflammati2.43466727
16MP0010155_abnormal_intestine_physiology2.38810942
17MP0002723_abnormal_immune_serum2.30052651
18MP0003172_abnormal_lysosome_physiology2.29371734
19MP0003724_increased_susceptibility_to2.28680700
20MP0003436_decreased_susceptibility_to2.19700393
21MP0002420_abnormal_adaptive_immunity2.14324807
22MP0002452_abnormal_antigen_presenting2.11701778
23MP0001819_abnormal_immune_cell2.09421815
24MP0005025_abnormal_response_to2.08077955
25MP0002006_tumorigenesis1.99926330
26MP0002398_abnormal_bone_marrow1.94731628
27MP0000703_abnormal_thymus_morphology1.93528061
28MP0002148_abnormal_hypersensitivity_rea1.93141903
29MP0006082_CNS_inflammation1.90584629
30MP0002419_abnormal_innate_immunity1.83964923
31MP0000685_abnormal_immune_system1.81501778
32MP0005464_abnormal_platelet_physiology1.79642643
33MP0000716_abnormal_immune_system1.68683271
34MP0002277_abnormal_respiratory_mucosa1.66165837
35MP0001849_ear_inflammation1.64102203
36MP0000015_abnormal_ear_pigmentation1.61154709
37MP0003329_amyloid_beta_deposits1.58923404
38MP0003866_abnormal_defecation1.53868738
39MP0004381_abnormal_hair_follicle1.50791588
40MP0002722_abnormal_immune_system1.49485337
41MP0000689_abnormal_spleen_morphology1.45794964
42MP0000681_abnormal_thyroid_gland1.44000584
43MP0004084_abnormal_cardiac_muscle1.41351942
44MP0002837_dystrophic_cardiac_calcinosis1.40489891
45MP0000465_gastrointestinal_hemorrhage1.40306407
46MP0002933_joint_inflammation1.40216204
47MP0003045_fibrosis1.36623569
48MP0002429_abnormal_blood_cell1.36180285
49MP0008057_abnormal_DNA_replication1.36159063
50MP0003300_gastrointestinal_ulcer1.36133724
51MP0000372_irregular_coat_pigmentation1.35751804
52MP0003806_abnormal_nucleotide_metabolis1.32378942
53MP0001845_abnormal_inflammatory_respons1.30488009
54MP0000604_amyloidosis1.30420173
55MP0001986_abnormal_taste_sensitivity1.30112438
56MP0004947_skin_inflammation1.26297045
57MP0005174_abnormal_tail_pigmentation1.26088269
58MP0005075_abnormal_melanosome_morpholog1.24396453
59MP0009278_abnormal_bone_marrow1.22972386
60MP0003448_altered_tumor_morphology1.10442815
61MP0000569_abnormal_digit_pigmentation1.08977125
62MP0009384_cardiac_valve_regurgitation1.06553669
63MP0004510_myositis1.05399098
64MP0002653_abnormal_ependyma_morphology1.02581110
65MP0001533_abnormal_skeleton_physiology1.01884920
66MP0005310_abnormal_salivary_gland1.00627532
67MP0001764_abnormal_homeostasis0.96102711
68MP0003191_abnormal_cellular_cholesterol0.95417115
69MP0008469_abnormal_protein_level0.95113436
70MP0003303_peritoneal_inflammation0.94175854
71MP0005266_abnormal_metabolism0.87348627
72MP0002249_abnormal_larynx_morphology0.87084396
73MP0001663_abnormal_digestive_system0.86572811
74MP0005670_abnormal_white_adipose0.84302558
75MP0005535_abnormal_body_temperature0.83767544
76MP0005319_abnormal_enzyme/_coenzyme0.80532938
77MP0002019_abnormal_tumor_incidence0.80348290
78MP0005166_decreased_susceptibility_to0.73752280
79MP0005397_hematopoietic_system_phenotyp0.70298888
80MP0001545_abnormal_hematopoietic_system0.70298888
81MP0001851_eye_inflammation0.67864093
82MP0005666_abnormal_adipose_tissue0.67085925
83MP0000371_diluted_coat_color0.65729302
84MP0000477_abnormal_intestine_morphology0.65447530
85MP0002693_abnormal_pancreas_physiology0.64983361
86MP0001502_abnormal_circadian_rhythm0.64719217
87MP0008569_lethality_at_weaning0.62993357
88MP0009764_decreased_sensitivity_to0.59500343
89MP0008961_abnormal_basal_metabolism0.58394029
90MP0009115_abnormal_fat_cell0.56702357
91MP0008995_early_reproductive_senescence0.56561040
92MP0003690_abnormal_glial_cell0.56375953
93MP0004036_abnormal_muscle_relaxation0.56324380
94MP0002971_abnormal_brown_adipose0.55443975
95MP0002998_abnormal_bone_remodeling0.52918307
96MP0009765_abnormal_xenobiotic_induced0.51945215
97MP0002132_abnormal_respiratory_system0.51262540
98MP0001881_abnormal_mammary_gland0.50842467
99MP0003279_aneurysm0.50413382
100MP0006035_abnormal_mitochondrial_morpho0.49741233

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.43625746
2Pustule (HP:0200039)5.14646527
3T lymphocytopenia (HP:0005403)4.80053210
4Reduced antithrombin III activity (HP:0001976)4.68291110
5Amniotic constriction ring (HP:0009775)4.35978501
6Abnormality of placental membranes (HP:0011409)4.35978501
7Recurrent cutaneous fungal infections (HP:0011370)4.32334432
8Chronic mucocutaneous candidiasis (HP:0002728)4.32334432
9Abnormality of T cell number (HP:0011839)4.30083933
10Cheilitis (HP:0100825)4.07784951
11Abnormality of the intrinsic pathway (HP:0010989)4.05052594
12J-shaped sella turcica (HP:0002680)3.85133853
13Elevated erythrocyte sedimentation rate (HP:0003565)3.82157331
14Autoimmune hemolytic anemia (HP:0001890)3.65901824
15Recurrent fungal infections (HP:0002841)3.63086950
16Severe combined immunodeficiency (HP:0004430)3.62585940
17IgG deficiency (HP:0004315)3.61026137
18Abnormality of T cells (HP:0002843)3.56774953
19Type I transferrin isoform profile (HP:0003642)3.55175991
20Inflammation of the large intestine (HP:0002037)3.44401628
21Myositis (HP:0100614)3.42561109
22Increased IgM level (HP:0003496)3.42183872
23Volvulus (HP:0002580)3.41127614
24Encephalitis (HP:0002383)3.37658321
25Gingival bleeding (HP:0000225)3.37392446
26Retrobulbar optic neuritis (HP:0100654)3.36023629
27Optic neuritis (HP:0100653)3.36023629
28Gastrointestinal inflammation (HP:0004386)3.33427150
29IgM deficiency (HP:0002850)3.22495848
30Orchitis (HP:0100796)3.17746115
31Chronic diarrhea (HP:0002028)3.11969434
32Hemoptysis (HP:0002105)3.02624356
33Abnormality of oral frenula (HP:0000190)3.01841344
34Meningitis (HP:0001287)2.91292619
35Eczematoid dermatitis (HP:0000976)2.90785921
36Combined immunodeficiency (HP:0005387)2.87643502
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.87565205
38Absent/shortened dynein arms (HP:0200106)2.85678231
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.85678231
40Gingivitis (HP:0000230)2.81072040
41Rhabdomyolysis (HP:0003201)2.74183087
42Premature loss of primary teeth (HP:0006323)2.72842445
43Increased IgE level (HP:0003212)2.72798401
44Gastrointestinal infarctions (HP:0005244)2.69241202
45Xerostomia (HP:0000217)2.68860020
46Abnormality of the prostate (HP:0008775)2.68202830
47Vasculitis (HP:0002633)2.65723763
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.64588795
49Abnormal protein N-linked glycosylation (HP:0012347)2.64588795
50Abnormal protein glycosylation (HP:0012346)2.64588795
51Abnormal glycosylation (HP:0012345)2.64588795
52Pulmonary infiltrates (HP:0002113)2.63645348
53Abnormality of T cell physiology (HP:0011840)2.59686363
54Obstructive lung disease (HP:0006536)2.58785214
55Chronic obstructive pulmonary disease (HP:0006510)2.58785214
56Prolonged bleeding time (HP:0003010)2.56481879
57Recurrent bronchitis (HP:0002837)2.55427578
58Keratoconjunctivitis sicca (HP:0001097)2.55178344
59Trismus (HP:0000211)2.53726484
60Recurrent skin infections (HP:0001581)2.51355341
61Abnormality of eosinophils (HP:0001879)2.49334696
62Mediastinal lymphadenopathy (HP:0100721)2.49147247
63Agammaglobulinemia (HP:0004432)2.45410736
64Spontaneous hematomas (HP:0007420)2.44407894
65Abnormality of macrophages (HP:0004311)2.44301993
66Chronic sinusitis (HP:0011109)2.43882691
67Chest pain (HP:0100749)2.41967391
68Broad face (HP:0000283)2.40603715
69Poikiloderma (HP:0001029)2.39068669
70Urticaria (HP:0001025)2.36304881
71Respiratory difficulties (HP:0002880)2.34791375
72Keratoconjunctivitis (HP:0001096)2.32288829
73Leukocytosis (HP:0001974)2.31098682
74Abnormality of the endocardium (HP:0004306)2.30606576
75Ankyloglossia (HP:0010296)2.30115036
76Gangrene (HP:0100758)2.29987834
77Thyroiditis (HP:0100646)2.29816337
78Biconcave vertebral bodies (HP:0004586)2.28958353
79Hypergammaglobulinemia (HP:0010702)2.27173664
80Recurrent abscess formation (HP:0002722)2.25072866
81Cerebral palsy (HP:0100021)2.20957019
82Abnormality of pyrimidine metabolism (HP:0004353)2.20698884
83Epistaxis (HP:0000421)2.20184386
84Periodontitis (HP:0000704)2.20158157
85Hypoproteinemia (HP:0003075)2.16131169
86Joint swelling (HP:0001386)2.15737698
87Recurrent viral infections (HP:0004429)2.15641393
88Abnormality of the preputium (HP:0100587)2.15115638
89Granulocytopenia (HP:0001913)2.12147609
90Pulmonary embolism (HP:0002204)2.10811393
91Increased intramyocellular lipid droplets (HP:0012240)2.09229928
92Cervical subluxation (HP:0003308)2.08229391
93B lymphocytopenia (HP:0010976)2.06804925
94Spinal canal stenosis (HP:0003416)2.05863220
95Eosinophilia (HP:0001880)2.03146343
96Obstructive sleep apnea (HP:0002870)2.02554800
97Hyperlipoproteinemia (HP:0010980)2.02000767
98Recurrent bacterial skin infections (HP:0005406)2.00789893
99Ridged nail (HP:0001807)2.00684403
100Polyneuropathy (HP:0001271)1.97128874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.24417914
2TXK4.73874909
3MAP4K14.03550809
4GRK63.47397589
5ITK3.31838082
6CAMKK23.11747457
7SYK3.08247696
8FES2.84414942
9MAP3K132.81611285
10TNK22.59289295
11CSF1R2.37996163
12CDK32.19148656
13MAP3K142.17059190
14CSK2.12053027
15MAPK122.11703938
16CAMKK11.89118610
17MAPK71.79905746
18JAK31.75285262
19HCK1.72022988
20BTK1.69940328
21TYK21.69315999
22PASK1.68779631
23VRK11.59549922
24LCK1.56253513
25RIPK41.51916728
26KDR1.44847523
27TEC1.44102913
28KIT1.40151345
29NLK1.26409172
30IKBKE1.23277880
31PRKCQ1.19344128
32TAOK31.14464980
33IRAK21.14017836
34IRAK11.10846007
35IKBKB1.10436389
36ZAP701.06366722
37CAMK1D1.06351178
38PIK3CG1.05460654
39SIK31.00981654
40JAK11.00601222
41PIM10.93570267
42LYN0.93227643
43VRK20.89360155
44IGF1R0.88722489
45STK100.87050123
46MAP2K60.83745603
47JAK20.80069666
48BLK0.77325475
49NUAK10.71797288
50TBK10.67807251
51FYN0.67236099
52PRKCH0.66325553
53STK240.64806352
54YES10.63383680
55EIF2AK30.62763096
56TESK20.61949856
57MAP3K110.61945344
58NME20.59755275
59FGFR40.59176850
60MAP3K70.57207120
61TAOK20.56519879
62EPHB10.55110344
63MAP2K30.54728675
64IRAK40.51795959
65MARK30.50712780
66BRSK20.50645496
67PRKCD0.49142042
68CDK190.48042760
69ERN10.48030164
70TAOK10.47354056
71RPS6KB10.45453302
72PRPF4B0.45039053
73BMX0.44286468
74CAMK1G0.43987655
75ADRBK20.39721647
76LRRK20.35487876
77MAPKAPK30.34951389
78EPHA30.34846317
79GRK70.33692224
80MAP3K30.33252895
81GRK10.33243675
82CDK40.33156316
83ACVR1B0.32063275
84CAMK10.30572891
85PRKCE0.29915726
86MATK0.28954797
87TYRO30.27445976
88INSR0.26009979
89STK40.23578964
90PRKAA20.22452049
91EGFR0.22113703
92MAPKAPK20.21813790
93MAPK100.21046883
94PRKCA0.19993150
95CSNK2A10.19167860
96RAF10.18366449
97ATR0.16937815
98TGFBR20.16772133
99MAPK110.16155679
100PRKDC0.15275756

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.52932206
2Allograft rejection_Homo sapiens_hsa053304.06983708
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.77796499
4Type I diabetes mellitus_Homo sapiens_hsa049403.56897364
5Autoimmune thyroid disease_Homo sapiens_hsa053203.54899127
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.54280518
7Graft-versus-host disease_Homo sapiens_hsa053323.51475188
8T cell receptor signaling pathway_Homo sapiens_hsa046602.82568008
9Proteasome_Homo sapiens_hsa030502.44880846
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.41699077
11Measles_Homo sapiens_hsa051622.05743314
12Antigen processing and presentation_Homo sapiens_hsa046122.05568588
13Hematopoietic cell lineage_Homo sapiens_hsa046402.02486648
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94109731
15Regulation of autophagy_Homo sapiens_hsa041401.74059455
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.69228843
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.66098340
18African trypanosomiasis_Homo sapiens_hsa051431.63912584
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63547839
20Viral myocarditis_Homo sapiens_hsa054161.57996438
21Leishmaniasis_Homo sapiens_hsa051401.55849455
22Malaria_Homo sapiens_hsa051441.50771744
23Osteoclast differentiation_Homo sapiens_hsa043801.41250895
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38262397
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37002340
26Selenocompound metabolism_Homo sapiens_hsa004501.35063984
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32340206
28Herpes simplex infection_Homo sapiens_hsa051681.31672012
29Asthma_Homo sapiens_hsa053101.29143079
30B cell receptor signaling pathway_Homo sapiens_hsa046621.23170590
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.22270151
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.20361385
33Pentose phosphate pathway_Homo sapiens_hsa000301.15165980
34Chemokine signaling pathway_Homo sapiens_hsa040621.11427000
35Acute myeloid leukemia_Homo sapiens_hsa052211.11384418
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10298395
37Shigellosis_Homo sapiens_hsa051311.05516488
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03908259
39Staphylococcus aureus infection_Homo sapiens_hsa051501.01632586
40Apoptosis_Homo sapiens_hsa042101.00080503
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97381611
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96753281
43Rheumatoid arthritis_Homo sapiens_hsa053230.95872066
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95001763
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93215069
46RNA degradation_Homo sapiens_hsa030180.88909892
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85293272
48N-Glycan biosynthesis_Homo sapiens_hsa005100.80330356
49Hepatitis B_Homo sapiens_hsa051610.80227595
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79437140
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78462274
52Epstein-Barr virus infection_Homo sapiens_hsa051690.78038139
53Influenza A_Homo sapiens_hsa051640.77727254
54Toxoplasmosis_Homo sapiens_hsa051450.76952536
55Purine metabolism_Homo sapiens_hsa002300.76765560
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75817054
57Viral carcinogenesis_Homo sapiens_hsa052030.75509066
58TNF signaling pathway_Homo sapiens_hsa046680.73174213
59Pyrimidine metabolism_Homo sapiens_hsa002400.69126573
60Legionellosis_Homo sapiens_hsa051340.68474083
61Tuberculosis_Homo sapiens_hsa051520.67836476
62Lysosome_Homo sapiens_hsa041420.60581269
63Platelet activation_Homo sapiens_hsa046110.58486992
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57024372
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.55968404
66Fanconi anemia pathway_Homo sapiens_hsa034600.50381335
67Systemic lupus erythematosus_Homo sapiens_hsa053220.46978417
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45504982
69Retinol metabolism_Homo sapiens_hsa008300.44068841
70RNA polymerase_Homo sapiens_hsa030200.42308375
71HTLV-I infection_Homo sapiens_hsa051660.40222544
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38791784
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37723703
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37384793
75Pertussis_Homo sapiens_hsa051330.30953867
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.30325370
77Hepatitis C_Homo sapiens_hsa051600.30314667
78Pancreatic cancer_Homo sapiens_hsa052120.29370756
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27288301
80Salmonella infection_Homo sapiens_hsa051320.26280821
81Endocytosis_Homo sapiens_hsa041440.26230717
82HIF-1 signaling pathway_Homo sapiens_hsa040660.25895897
83VEGF signaling pathway_Homo sapiens_hsa043700.25631328
84Renal cell carcinoma_Homo sapiens_hsa052110.25298151
85Spliceosome_Homo sapiens_hsa030400.24382256
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24016665
87MicroRNAs in cancer_Homo sapiens_hsa052060.23968585
88Ribosome_Homo sapiens_hsa030100.23041845
89Peroxisome_Homo sapiens_hsa041460.22621615
90Non-small cell lung cancer_Homo sapiens_hsa052230.20991406
91Homologous recombination_Homo sapiens_hsa034400.19402210
92Nucleotide excision repair_Homo sapiens_hsa034200.18701888
93Glycerolipid metabolism_Homo sapiens_hsa005610.16954268
94Phagosome_Homo sapiens_hsa041450.16217562
95Biosynthesis of amino acids_Homo sapiens_hsa012300.16071277
96mTOR signaling pathway_Homo sapiens_hsa041500.15092958
97Circadian rhythm_Homo sapiens_hsa047100.14200369
98Protein export_Homo sapiens_hsa030600.13515157
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.12747682
100MAPK signaling pathway_Homo sapiens_hsa040100.10262034

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