TRAV24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)9.09528878
2positive regulation of interleukin-17 production (GO:0032740)8.57013857
3regulation of natural killer cell differentiation (GO:0032823)8.07486234
4positive regulation of interferon-gamma biosynthetic process (GO:0045078)7.64712636
5negative regulation of T cell differentiation in thymus (GO:0033085)7.59083933
6cellular response to interleukin-15 (GO:0071350)7.42845558
7response to interleukin-15 (GO:0070672)7.14543763
8response to xenobiotic stimulus (GO:0009410)7.14064227
9regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)7.02521322
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)6.55959945
11regulation of isotype switching to IgG isotypes (GO:0048302)6.43937036
12positive regulation of natural killer cell mediated immunity (GO:0002717)6.43158599
13negative regulation of cell killing (GO:0031342)6.38232250
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.38232250
15positive regulation of T cell differentiation in thymus (GO:0033089)6.35710003
16positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.32113822
17cysteine metabolic process (GO:0006534)6.27606230
18regulation of gamma-delta T cell differentiation (GO:0045586)6.22460277
19regulation of interferon-gamma biosynthetic process (GO:0045072)5.97695128
20response to nitrosative stress (GO:0051409)5.88383341
21viral mRNA export from host cell nucleus (GO:0046784)5.80020521
22positive regulation of natural killer cell activation (GO:0032816)5.73614023
23regulation of T cell differentiation in thymus (GO:0033081)5.67881223
24positive regulation of T cell apoptotic process (GO:0070234)5.64791970
25regulation of chronic inflammatory response (GO:0002676)5.55114178
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.52145760
27regulation of natural killer cell mediated immunity (GO:0002715)5.52145760
28negative regulation of B cell mediated immunity (GO:0002713)5.50461873
29negative regulation of immunoglobulin mediated immune response (GO:0002890)5.50461873
30positive regulation of interleukin-10 production (GO:0032733)5.40388201
31regulation of gamma-delta T cell activation (GO:0046643)5.33690918
32regulation of interleukin-17 production (GO:0032660)5.17019847
33negative regulation of adaptive immune response (GO:0002820)5.12407761
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.11998793
35negative regulation of adaptive immune response based on somatic recombination of immune receptors b5.09563247
36positive regulation of chemokine biosynthetic process (GO:0045080)4.89950594
37negative regulation of lymphocyte mediated immunity (GO:0002707)4.85044729
38regulation of thymocyte apoptotic process (GO:0070243)4.77152756
39regulation of interleukin-12 biosynthetic process (GO:0045075)4.76804483
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.76563125
41negative regulation of T cell mediated immunity (GO:0002710)4.70132550
42regulation of leukocyte mediated cytotoxicity (GO:0001910)4.67030692
43regulation of isotype switching (GO:0045191)4.63148383
44negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.60456377
45negative regulation of T-helper cell differentiation (GO:0045623)4.60456377
46positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.58775899
47antigen processing and presentation of endogenous antigen (GO:0019883)4.37844002
48positive regulation of gamma-delta T cell activation (GO:0046645)4.30146840
49T cell lineage commitment (GO:0002360)4.23609617
50positive regulation of lymphocyte apoptotic process (GO:0070230)4.22644166
51production of molecular mediator of immune response (GO:0002440)4.21871417
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.19490996
53regulation of natural killer cell activation (GO:0032814)4.16947089
54regulation of immunoglobulin production (GO:0002637)4.16737697
55regulation of cell killing (GO:0031341)4.15371841
56negative regulation of T cell differentiation (GO:0045581)4.14895429
57positive regulation of B cell proliferation (GO:0030890)4.12264816
58positive regulation of isotype switching (GO:0045830)4.07403433
59positive regulation of cell killing (GO:0031343)4.01661819
60L-ascorbic acid metabolic process (GO:0019852)3.99394863
61positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.95545821
62regulation of chemokine biosynthetic process (GO:0045073)3.91070977
63regulation of interleukin-10 production (GO:0032653)3.90580320
64S-adenosylmethionine metabolic process (GO:0046500)3.88401557
65regulation of mitochondrial depolarization (GO:0051900)3.85384021
66positive regulation of cytokine biosynthetic process (GO:0042108)3.77708785
67regulation of T cell mediated cytotoxicity (GO:0001914)3.74500123
68Peyers patch development (GO:0048541)3.70657523
69mucosal-associated lymphoid tissue development (GO:0048537)3.70657523
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.68643627
71defense response to protozoan (GO:0042832)3.62765394
72negative regulation of leukocyte mediated immunity (GO:0002704)3.62209651
73positive regulation of lymphocyte mediated immunity (GO:0002708)3.55468781
74regulation of lymphocyte mediated immunity (GO:0002706)3.54469105
75positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.48562420
76positive regulation of DNA recombination (GO:0045911)3.45197087
77positive regulation of lymphocyte differentiation (GO:0045621)3.39654854
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.33801060
79tolerance induction (GO:0002507)3.33788960
80positive regulation of B cell activation (GO:0050871)3.33047870
81negative regulation of lymphocyte differentiation (GO:0045620)3.27356065
82regulation of immunoglobulin mediated immune response (GO:0002889)3.26489344
83positive regulation of production of molecular mediator of immune response (GO:0002702)3.22827822
84positive regulation of immunoglobulin production (GO:0002639)3.22365349
85regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.22098139
86natural killer cell differentiation (GO:0001779)3.20377165
87cytokine production involved in immune response (GO:0002367)3.20294240
88negative regulation of alpha-beta T cell differentiation (GO:0046639)3.18654087
89regulation of B cell mediated immunity (GO:0002712)3.18469331
90positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.18153928
91glutathione biosynthetic process (GO:0006750)3.17399705
92regulation of production of molecular mediator of immune response (GO:0002700)3.17200740
93response to protozoan (GO:0001562)3.16943779
94regulation of B cell activation (GO:0050864)3.15257018
95positive regulation of leukocyte mediated immunity (GO:0002705)3.12178801
96negative regulation of production of molecular mediator of immune response (GO:0002701)3.09298265
97positive regulation of cytokine production involved in immune response (GO:0002720)3.08850397
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08358820
99positive regulation of tissue remodeling (GO:0034105)3.02448600
100positive regulation of natural killer cell differentiation (GO:0032825)11.6369929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.02662189
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.02678956
3NOTCH1_21737748_ChIP-Seq_TLL_Human5.19364067
4IRF8_22096565_ChIP-ChIP_GC-B_Human5.14615243
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.00135875
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.79101119
7RUNX_20019798_ChIP-Seq_JUKART_Human3.56873592
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.52289376
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.51198375
10MYB_26560356_Chip-Seq_TH2_Human3.07529307
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95333725
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80940762
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76720737
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.68116844
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66300478
16MYC_22102868_ChIP-Seq_BL_Human2.57485464
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.52813001
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43607139
19MAF_26560356_Chip-Seq_TH1_Human2.42711888
20MYB_26560356_Chip-Seq_TH1_Human2.42672667
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39925873
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05343096
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.02796317
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.95103432
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91525742
26GATA3_26560356_Chip-Seq_TH2_Human1.90142510
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.87100408
28GATA3_27048872_Chip-Seq_THYMUS_Human1.84549257
29RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.72940562
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61085407
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60991239
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58330120
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55932722
34MAF_26560356_Chip-Seq_TH2_Human1.54391969
35UTX_26944678_Chip-Seq_JUKART_Human1.53802481
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53791142
37SPI1_23547873_ChIP-Seq_NB4_Human1.52738539
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49042097
39TCF7_22412390_ChIP-Seq_EML_Mouse1.45299059
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.44720427
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42950500
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42266208
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37358966
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28434341
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28013538
46VDR_21846776_ChIP-Seq_THP-1_Human1.26140322
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25958857
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25414154
49VDR_23849224_ChIP-Seq_CD4+_Human1.20921582
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18709358
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18652191
52VDR_24763502_ChIP-Seq_THP-1_Human1.17191802
53SCL_19346495_ChIP-Seq_HPC-7_Human1.16206898
54VDR_22108803_ChIP-Seq_LS180_Human1.14077606
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09821329
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07949288
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06814441
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06699599
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06622960
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02402610
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98349148
62GATA1_22025678_ChIP-Seq_K562_Human0.98018686
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97241884
64EGR1_19032775_ChIP-ChIP_M12_Human0.96872274
65VDR_24787735_ChIP-Seq_THP-1_Human0.96102283
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92713396
67KDM2B_26808549_Chip-Seq_JURKAT_Human0.92217880
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92146259
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91701377
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88986348
71ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88103226
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87563589
73GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87084262
74RUNX1_22412390_ChIP-Seq_EML_Mouse0.83814565
75BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83414066
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83041014
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81508003
78SPI1_20517297_ChIP-Seq_HL60_Human0.81223394
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80816000
80KDM2B_26808549_Chip-Seq_DND41_Human0.79748375
81STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79625138
82FOXP3_21729870_ChIP-Seq_TREG_Human0.78632641
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78631320
84SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77930271
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77919898
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77252542
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.76900463
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75455018
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75396072
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73744125
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73121293
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72671993
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.72321081
94CEBPB_22108803_ChIP-Seq_LS180_Human0.72079026
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.71727926
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.69675310
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.69269431
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.69071499
99BCL6_27268052_Chip-Seq_Bcells_Human0.67152691
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.65920633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland5.29087379
2MP0001873_stomach_inflammation4.47609056
3MP0003763_abnormal_thymus_physiology4.12341704
4MP0001835_abnormal_antigen_presentation3.96010322
5MP0006082_CNS_inflammation3.56210274
6MP0003436_decreased_susceptibility_to3.38070518
7MP0004742_abnormal_vestibular_system3.26919330
8MP0000685_abnormal_immune_system3.26134429
9MP0005387_immune_system_phenotype3.17385768
10MP0001790_abnormal_immune_system3.17385768
11MP0005671_abnormal_response_to3.02672027
12MP0005000_abnormal_immune_tolerance2.94853698
13MP0001800_abnormal_humoral_immune2.73698859
14MP0003890_abnormal_embryonic-extraembry2.58465210
15MP0008057_abnormal_DNA_replication2.47127627
16MP0000750_abnormal_muscle_regeneration2.41381105
17MP0005423_abnormal_somatic_nervous2.31767489
18MP0002723_abnormal_immune_serum2.25799397
19MP0005310_abnormal_salivary_gland2.24233258
20MP0001986_abnormal_taste_sensitivity2.21529811
21MP0002405_respiratory_system_inflammati2.18661645
22MP0002138_abnormal_hepatobiliary_system2.17390331
23MP0002420_abnormal_adaptive_immunity2.16333918
24MP0002452_abnormal_antigen_presenting2.12836388
25MP0009785_altered_susceptibility_to2.09365812
26MP0010155_abnormal_intestine_physiology2.03815256
27MP0001819_abnormal_immune_cell2.00925289
28MP0000569_abnormal_digit_pigmentation1.98166821
29MP0005025_abnormal_response_to1.97263625
30MP0003724_increased_susceptibility_to1.89800943
31MP0003646_muscle_fatigue1.89481157
32MP0002254_reproductive_system_inflammat1.88206267
33MP0004381_abnormal_hair_follicle1.81075233
34MP0002398_abnormal_bone_marrow1.78102590
35MP0000716_abnormal_immune_system1.67468955
36MP0003806_abnormal_nucleotide_metabolis1.61925770
37MP0000689_abnormal_spleen_morphology1.59132025
38MP0009333_abnormal_splenocyte_physiolog1.57096258
39MP0004134_abnormal_chest_morphology1.54738195
40MP0000703_abnormal_thymus_morphology1.53645495
41MP0003943_abnormal_hepatobiliary_system1.49469728
42MP0002419_abnormal_innate_immunity1.49299776
43MP0002132_abnormal_respiratory_system1.49243229
44MP0001845_abnormal_inflammatory_respons1.42884974
45MP0008872_abnormal_physiological_respon1.36720010
46MP0003866_abnormal_defecation1.31845349
47MP0002722_abnormal_immune_system1.31672967
48MP0004808_abnormal_hematopoietic_stem1.30702073
49MP0002429_abnormal_blood_cell1.22684459
50MP0010368_abnormal_lymphatic_system1.18805690
51MP0001968_abnormal_touch/_nociception1.17675534
52MP0003045_fibrosis1.13092051
53MP0002148_abnormal_hypersensitivity_rea1.10771154
54MP0008469_abnormal_protein_level1.08602105
55MP0001533_abnormal_skeleton_physiology1.08484060
56MP0002102_abnormal_ear_morphology1.00358387
57MP0003221_abnormal_cardiomyocyte_apopto0.99925285
58MP0004142_abnormal_muscle_tone0.98978597
59MP0002269_muscular_atrophy0.98950616
60MP0004947_skin_inflammation0.97358980
61MP0001243_abnormal_dermal_layer0.93497546
62MP0001663_abnormal_digestive_system0.92697991
63MP0009840_abnormal_foam_cell0.92320268
64MP0001851_eye_inflammation0.92227464
65MP0005408_hypopigmentation0.87909924
66MP0004145_abnormal_muscle_electrophysio0.87203571
67MP0009764_decreased_sensitivity_to0.87084432
68MP0000465_gastrointestinal_hemorrhage0.86802424
69MP0002693_abnormal_pancreas_physiology0.85178518
70MP0008875_abnormal_xenobiotic_pharmacok0.79051877
71MP0005075_abnormal_melanosome_morpholog0.77549570
72MP0002163_abnormal_gland_morphology0.75952405
73MP0001501_abnormal_sleep_pattern0.75485825
74MP0005166_decreased_susceptibility_to0.75269990
75MP0002736_abnormal_nociception_after0.74196033
76MP0000015_abnormal_ear_pigmentation0.70062155
77MP0002106_abnormal_muscle_physiology0.68519894
78MP0003329_amyloid_beta_deposits0.67465428
79MP0005647_abnormal_sex_gland0.64666306
80MP0001502_abnormal_circadian_rhythm0.64014088
81MP0003795_abnormal_bone_structure0.63061817
82MP0000604_amyloidosis0.62318849
83MP0001958_emphysema0.61319150
84MP0003633_abnormal_nervous_system0.61291623
85MP0005390_skeleton_phenotype0.59910784
86MP0003303_peritoneal_inflammation0.57558308
87MP0008961_abnormal_basal_metabolism0.51250257
88MP0000470_abnormal_stomach_morphology0.50322420
89MP0003300_gastrointestinal_ulcer0.49467885
90MP0002166_altered_tumor_susceptibility0.49316679
91MP0005381_digestive/alimentary_phenotyp0.47165435
92MP0002933_joint_inflammation0.44642801
93MP0002229_neurodegeneration0.43076331
94MP0000858_altered_metastatic_potential0.42156046
95MP0003186_abnormal_redox_activity0.41823100
96MP0005369_muscle_phenotype0.41499139
97MP0001881_abnormal_mammary_gland0.40268704
98MP0002998_abnormal_bone_remodeling0.40177077
99MP0009745_abnormal_behavioral_response0.40084719
100MP0000313_abnormal_cell_death0.39570467

Predicted human phenotypes

RankGene SetZ-score
1Chronic diarrhea (HP:0002028)9.41310418
2Stomatitis (HP:0010280)7.17246534
3Severe combined immunodeficiency (HP:0004430)6.65373804
4T lymphocytopenia (HP:0005403)6.61283430
5Abnormality of T cell number (HP:0011839)5.99143908
6Inflammation of the large intestine (HP:0002037)5.58451287
7Thyroiditis (HP:0100646)5.54910218
8Combined immunodeficiency (HP:0005387)5.33198862
9Gastrointestinal inflammation (HP:0004386)5.25363659
10Increased IgM level (HP:0003496)4.75645589
11Abnormality of T cells (HP:0002843)4.70007294
12Abnormality of eosinophils (HP:0001879)4.30648625
13Acute myeloid leukemia (HP:0004808)3.98815613
14Nasal polyposis (HP:0100582)3.86535044
15Amyotrophic lateral sclerosis (HP:0007354)3.79010120
16Abnormality of incisor morphology (HP:0011063)3.74748929
17IgG deficiency (HP:0004315)3.59192936
18Recurrent bronchitis (HP:0002837)3.52783840
19Chronic otitis media (HP:0000389)3.46104002
20Bilateral sensorineural hearing impairment (HP:0008619)3.45746353
21Leukocytosis (HP:0001974)3.40425259
22Elevated erythrocyte sedimentation rate (HP:0003565)3.37811389
23Curly hair (HP:0002212)3.35398614
24Abnormality of the nasal mucosa (HP:0000433)3.33524752
25Recurrent fungal infections (HP:0002841)3.26270902
26Recurrent bacterial skin infections (HP:0005406)3.21913955
27Recurrent cutaneous fungal infections (HP:0011370)3.20244887
28Chronic mucocutaneous candidiasis (HP:0002728)3.20244887
29Megalencephaly (HP:0001355)3.13009136
30Recurrent skin infections (HP:0001581)3.11250783
31Abnormality of T cell physiology (HP:0011840)3.09616478
32Entropion (HP:0000621)3.06010647
33Abnormality of DNA repair (HP:0003254)2.98210433
34Cutaneous melanoma (HP:0012056)2.96570004
35IgA deficiency (HP:0002720)2.86231762
36Mediastinal lymphadenopathy (HP:0100721)2.86226525
37Pustule (HP:0200039)2.83888969
38Recurrent abscess formation (HP:0002722)2.79674920
39B lymphocytopenia (HP:0010976)2.77956113
40Pulmonary infiltrates (HP:0002113)2.69428338
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.66631027
42Mutism (HP:0002300)2.65534817
43Gingivitis (HP:0000230)2.61111492
44Myositis (HP:0100614)2.59953444
45Fatigue (HP:0012378)2.57614904
46Bronchitis (HP:0012387)2.55587601
47Poikiloderma (HP:0001029)2.45280048
48Abnormality of B cell number (HP:0010975)2.44883363
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.42425587
50Eczematoid dermatitis (HP:0000976)2.41880380
51Melanoma (HP:0002861)2.36834358
52Gastrointestinal infarctions (HP:0005244)2.34191944
53Polyneuropathy (HP:0001271)2.32933082
54Basal cell carcinoma (HP:0002671)2.27840331
55Keratoconjunctivitis (HP:0001096)2.27311425
56Lymphoma (HP:0002665)2.18977092
57Orchitis (HP:0100796)2.13445613
58Oral leukoplakia (HP:0002745)2.13043487
59Keratitis (HP:0000491)2.11417148
60Cystic hygroma (HP:0000476)2.09312149
61Aplastic anemia (HP:0001915)2.08183496
62Chronic sinusitis (HP:0011109)2.04648976
63Optic neuritis (HP:0100653)2.02024052
64Retrobulbar optic neuritis (HP:0100654)2.02024052
65Upper limb muscle weakness (HP:0003484)2.00699192
66Metaphyseal dysplasia (HP:0100255)1.97796612
67Abnormality of macrophages (HP:0004311)1.97393187
68Abnormality of the endocardium (HP:0004306)1.95887642
69Alveolar cell carcinoma (HP:0006519)1.95493624
70Chest pain (HP:0100749)1.93722451
71Hypergammaglobulinemia (HP:0010702)1.90065660
72Pruritus (HP:0000989)1.88230006
73Autoimmune hemolytic anemia (HP:0001890)1.85966903
74Type I diabetes mellitus (HP:0100651)1.85695709
75Hypoplasia of the thymus (HP:0000778)1.85388873
76Eosinophilia (HP:0001880)1.83864194
77Keratoconjunctivitis sicca (HP:0001097)1.83204595
78Agammaglobulinemia (HP:0004432)1.81614153
79Somatic mutation (HP:0001428)1.81166860
80Pancreatic islet-cell hyperplasia (HP:0004510)1.78522228
81Abnormality of the costochondral junction (HP:0000919)1.75571481
82Vasculitis (HP:0002633)1.75074427
83Neutropenia (HP:0001875)1.74010218
84Gingival bleeding (HP:0000225)1.71654976
85Chronic hepatic failure (HP:0100626)1.71390566
86Cubitus valgus (HP:0002967)1.70937405
87Hemoptysis (HP:0002105)1.70647853
88Hypobetalipoproteinemia (HP:0003563)1.70461346
89Neoplasm of the tracheobronchial system (HP:0100552)1.70138537
90Retinal dysplasia (HP:0007973)1.68570269
91Recurrent viral infections (HP:0004429)1.66800394
92Muscle fibrillation (HP:0010546)1.65362230
93Polycythemia (HP:0001901)1.64335420
94Coarse hair (HP:0002208)1.63070731
95Deep philtrum (HP:0002002)1.63021898
96Abnormality of the distal phalanx of the thumb (HP:0009617)1.62122325
97Meningitis (HP:0001287)1.61983758
98Tongue fasciculations (HP:0001308)1.61068069
99Cerebral hemorrhage (HP:0001342)1.60231822
100Arterial thrombosis (HP:0004420)1.58368151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR24.55662758
2PAK63.70261857
3HIPK23.46648119
4KSR13.35693801
5MAP4K13.05924870
6RAF12.91843036
7DYRK22.88465439
8TXK2.80910663
9EIF2AK32.63249543
10TAOK32.58060103
11ITK2.46245014
12AKT32.37902338
13MAP3K122.30939535
14PAK32.30154086
15LATS12.27720023
16JAK12.23263443
17MST42.15084512
18TYK22.04127909
19JAK31.85967071
20IKBKB1.74858299
21TAOK11.71803815
22NLK1.63012511
23TAOK21.60122163
24NUAK11.59552475
25PRKAA21.59462615
26BRD41.57305533
27JAK21.54729054
28ZAP701.52286230
29RIPK41.52282031
30BTK1.47846654
31HCK1.40687353
32CLK11.36751400
33MAP2K31.33077414
34NME11.32255177
35CHUK1.26789198
36EIF2AK11.21034603
37TNK21.16471257
38FES1.15651038
39MAP3K111.13456555
40MAP3K141.09555656
41TEC1.08163128
42NEK61.08055099
43MAP3K31.07542917
44SIK31.02951914
45LCK0.99186443
46ADRBK20.96064314
47CDK40.91664026
48SGK2230.90481185
49SGK4940.90481185
50CSK0.86771933
51LYN0.85483072
52SGK20.85369811
53EIF2AK20.82722266
54TIE10.81758144
55SCYL20.81151134
56TGFBR20.80121882
57SYK0.74526961
58MAP3K130.72608376
59PTK60.72362218
60GRK70.70692994
61SGK10.66583533
62RPS6KA10.64808129
63ACVR1B0.61540147
64MAP2K10.58833490
65MARK30.58270628
66CDK120.57622612
67STK100.56470809
68CSNK1A1L0.54372874
69BMPR20.53991884
70CAMKK10.52376543
71IKBKE0.51478371
72MYLK0.51257914
73PIM10.50534910
74IRAK40.48249395
75SGK30.45946557
76PRKCQ0.44565646
77CSF1R0.43228041
78GRK60.39907629
79DAPK10.38157272
80CDK190.36993527
81GSK3A0.35622235
82PDK10.33666825
83BLK0.33351208
84PAK40.29694633
85KIT0.28990664
86ERN10.28692049
87MAP2K60.28552318
88EPHB10.27753281
89STK380.27402275
90CSNK1A10.27125134
91PDK20.26904148
92PAK10.26194402
93CAMKK20.25804163
94MAPK110.25048011
95SMG10.24863564
96PRKCH0.24721855
97ADRBK10.22883093
98PRKCZ0.21015938
99PASK0.19883279
100TYRO30.19167227

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.26382339
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.42414100
3Allograft rejection_Homo sapiens_hsa053303.67430337
4Autoimmune thyroid disease_Homo sapiens_hsa053203.28472367
5Jak-STAT signaling pathway_Homo sapiens_hsa046303.10775085
6T cell receptor signaling pathway_Homo sapiens_hsa046602.98696684
7Asthma_Homo sapiens_hsa053102.83431810
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.56957232
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.50489482
10Cysteine and methionine metabolism_Homo sapiens_hsa002702.32058092
11Measles_Homo sapiens_hsa051622.19399701
12Hematopoietic cell lineage_Homo sapiens_hsa046402.06433127
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98255371
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.84029028
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.81717146
16Legionellosis_Homo sapiens_hsa051341.75115859
17Graft-versus-host disease_Homo sapiens_hsa053321.71525763
18Antigen processing and presentation_Homo sapiens_hsa046121.67447999
19Acute myeloid leukemia_Homo sapiens_hsa052211.59345318
20Leishmaniasis_Homo sapiens_hsa051401.52515563
21B cell receptor signaling pathway_Homo sapiens_hsa046621.50997189
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47548367
23Type I diabetes mellitus_Homo sapiens_hsa049401.40734794
24Osteoclast differentiation_Homo sapiens_hsa043801.33504625
25Prolactin signaling pathway_Homo sapiens_hsa049171.30407365
26Hepatitis B_Homo sapiens_hsa051611.29119604
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24959094
28Malaria_Homo sapiens_hsa051441.24667154
29Viral myocarditis_Homo sapiens_hsa054161.20803188
30TNF signaling pathway_Homo sapiens_hsa046681.20237929
31FoxO signaling pathway_Homo sapiens_hsa040681.19640312
32Apoptosis_Homo sapiens_hsa042101.18500405
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15268045
34Herpes simplex infection_Homo sapiens_hsa051681.13257542
35Toxoplasmosis_Homo sapiens_hsa051451.12336709
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11095004
37Glutathione metabolism_Homo sapiens_hsa004801.06868095
38Chemokine signaling pathway_Homo sapiens_hsa040621.06854436
39Tuberculosis_Homo sapiens_hsa051521.00863820
40Regulation of autophagy_Homo sapiens_hsa041400.98312731
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96963675
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86407655
43VEGF signaling pathway_Homo sapiens_hsa043700.84432165
44Influenza A_Homo sapiens_hsa051640.83506081
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81735261
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75901477
47HTLV-I infection_Homo sapiens_hsa051660.75742437
48Vitamin digestion and absorption_Homo sapiens_hsa049770.75340074
49p53 signaling pathway_Homo sapiens_hsa041150.73511402
50African trypanosomiasis_Homo sapiens_hsa051430.73079940
51Viral carcinogenesis_Homo sapiens_hsa052030.71581485
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.68405466
53Hepatitis C_Homo sapiens_hsa051600.67527557
54Nitrogen metabolism_Homo sapiens_hsa009100.64519283
55Non-small cell lung cancer_Homo sapiens_hsa052230.63897048
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63694564
57RNA transport_Homo sapiens_hsa030130.63115945
58Chronic myeloid leukemia_Homo sapiens_hsa052200.62856688
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55609119
60Pancreatic cancer_Homo sapiens_hsa052120.52648243
61Caffeine metabolism_Homo sapiens_hsa002320.51847178
62MAPK signaling pathway_Homo sapiens_hsa040100.51614521
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.51267612
64Insulin resistance_Homo sapiens_hsa049310.49937289
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49192907
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47575222
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46894627
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46459806
69Shigellosis_Homo sapiens_hsa051310.42554687
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41463097
71Staphylococcus aureus infection_Homo sapiens_hsa051500.41107773
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41062221
73Linoleic acid metabolism_Homo sapiens_hsa005910.40570485
74Colorectal cancer_Homo sapiens_hsa052100.39321622
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36537248
76Dorso-ventral axis formation_Homo sapiens_hsa043200.35786446
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35281977
78Fatty acid biosynthesis_Homo sapiens_hsa000610.34748222
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34678150
80Epstein-Barr virus infection_Homo sapiens_hsa051690.34138843
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30571138
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27038486
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.25298315
84Serotonergic synapse_Homo sapiens_hsa047260.24790824
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23972789
86Pertussis_Homo sapiens_hsa051330.23637657
87ErbB signaling pathway_Homo sapiens_hsa040120.23018853
88MicroRNAs in cancer_Homo sapiens_hsa052060.22763399
89Endometrial cancer_Homo sapiens_hsa052130.22418458
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22159844
91Phototransduction_Homo sapiens_hsa047440.21893651
92Platelet activation_Homo sapiens_hsa046110.21803140
93Mineral absorption_Homo sapiens_hsa049780.21447105
94Prostate cancer_Homo sapiens_hsa052150.20912630
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19644984
96Small cell lung cancer_Homo sapiens_hsa052220.18086162
97Rheumatoid arthritis_Homo sapiens_hsa053230.17877337
98Ras signaling pathway_Homo sapiens_hsa040140.17427932
99mRNA surveillance pathway_Homo sapiens_hsa030150.16660858
100Bladder cancer_Homo sapiens_hsa052190.16123618

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