TRAV25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of regulatory T cell differentiation (GO:0045589)9.72897129
2negative regulation of B cell proliferation (GO:0030889)6.14915311
3pyrimidine nucleoside catabolic process (GO:0046135)5.75125902
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.69710898
5positive thymic T cell selection (GO:0045059)5.55155631
6positive T cell selection (GO:0043368)5.52351221
7regulation of isotype switching to IgG isotypes (GO:0048302)5.19683378
8regulation of immunoglobulin secretion (GO:0051023)5.07676189
9positive regulation of lymphocyte migration (GO:2000403)5.05744680
10positive regulation of defense response to virus by host (GO:0002230)4.97902651
11negative regulation of viral genome replication (GO:0045071)4.89809046
12positive regulation of B cell differentiation (GO:0045579)4.85688945
13negative regulation of B cell activation (GO:0050869)4.77716834
14negative regulation by host of viral transcription (GO:0043922)4.75389972
15regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.74680458
16regulation of B cell differentiation (GO:0045577)4.68241918
17negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.67589645
18pyrimidine ribonucleoside metabolic process (GO:0046131)4.52735336
19Arp2/3 complex-mediated actin nucleation (GO:0034314)4.52179910
20positive regulation of interleukin-8 secretion (GO:2000484)4.46211821
21intestinal epithelial cell development (GO:0060576)4.36958259
22positive regulation of tolerance induction (GO:0002645)4.27486598
23negative regulation of B cell apoptotic process (GO:0002903)4.23440260
24positive regulation of gamma-delta T cell activation (GO:0046645)4.22328907
25adaptation of signaling pathway (GO:0023058)4.16274898
26regulation of lymphocyte chemotaxis (GO:1901623)4.16073156
27regulation of T cell tolerance induction (GO:0002664)4.11194466
28UMP metabolic process (GO:0046049)3.98896139
29pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.98896139
30UMP biosynthetic process (GO:0006222)3.98896139
31pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.98896139
32positive regulation of T cell migration (GO:2000406)3.96980459
33actin nucleation (GO:0045010)3.95811210
34interferon-gamma production (GO:0032609)3.92793324
35regulation of B cell receptor signaling pathway (GO:0050855)3.91832210
36eosinophil chemotaxis (GO:0048245)3.85099081
37negative T cell selection (GO:0043383)3.82686653
38positive regulation of isotype switching (GO:0045830)3.75666965
39regulation of lymphocyte migration (GO:2000401)3.73198225
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.72548451
41regulation of gamma-delta T cell differentiation (GO:0045586)3.71992041
42thymic T cell selection (GO:0045061)3.71293510
43positive regulation of interleukin-17 production (GO:0032740)3.68404171
44positive regulation of calcium-mediated signaling (GO:0050850)3.65964207
45regulation of gamma-delta T cell activation (GO:0046643)3.60555201
46negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.59206538
47positive regulation of DNA recombination (GO:0045911)3.57374473
48macrophage chemotaxis (GO:0048246)3.51867736
49DNA demethylation (GO:0080111)3.51233774
50eosinophil migration (GO:0072677)3.48074628
51cellular response to interleukin-15 (GO:0071350)3.46385638
52pyrimidine-containing compound catabolic process (GO:0072529)3.43659979
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43362230
54regulation of activation of Janus kinase activity (GO:0010533)3.42161470
55regulation of T cell migration (GO:2000404)3.39546787
56regulation of tolerance induction (GO:0002643)3.37002988
57negative regulation of T cell receptor signaling pathway (GO:0050860)3.36833278
58T cell costimulation (GO:0031295)3.34133724
59regulation of chronic inflammatory response (GO:0002676)3.33207481
60regulation of viral genome replication (GO:0045069)3.31239499
61lymphocyte costimulation (GO:0031294)3.29901176
62antigen processing and presentation via MHC class Ib (GO:0002475)3.29254112
63T cell selection (GO:0045058)3.28963588
64negative regulation of viral process (GO:0048525)3.27677247
65regulation of interleukin-8 secretion (GO:2000482)3.24870312
66negative regulation of lymphocyte apoptotic process (GO:0070229)3.24136581
67negative regulation of macroautophagy (GO:0016242)3.24111133
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19930214
69pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.10684485
70T cell receptor signaling pathway (GO:0050852)3.09151205
71natural killer cell activation (GO:0030101)3.08510962
72regulation of T cell receptor signaling pathway (GO:0050856)3.06173825
73regulation of B cell proliferation (GO:0030888)3.05316547
74maternal placenta development (GO:0001893)3.02989656
75chemokine-mediated signaling pathway (GO:0070098)3.00647218
76positive regulation of macrophage differentiation (GO:0045651)2.96806686
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95430205
78negative regulation of cell killing (GO:0031342)2.95430205
79antigen receptor-mediated signaling pathway (GO:0050851)2.95314007
80negative regulation of lymphocyte proliferation (GO:0050672)2.90764229
81negative regulation of mononuclear cell proliferation (GO:0032945)2.90764229
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89432027
83pyrimidine nucleoside metabolic process (GO:0006213)2.89193570
84regulation of defense response to virus by host (GO:0050691)2.86094779
85positive regulation of uterine smooth muscle contraction (GO:0070474)2.85604049
86pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.83713855
87negative thymic T cell selection (GO:0045060)2.82238979
88regulation of translational termination (GO:0006449)2.81226403
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80881771
90regulation of calcium-mediated signaling (GO:0050848)2.78992467
91negative regulation of leukocyte proliferation (GO:0070664)2.77682523
92response to interleukin-15 (GO:0070672)2.74484989
93antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72276092
94diterpenoid biosynthetic process (GO:0016102)2.71645128
95cytidine metabolic process (GO:0046087)13.8120902
96cytidine catabolic process (GO:0006216)13.8120902
97cytidine deamination (GO:0009972)13.8120902
98pyrimidine ribonucleoside catabolic process (GO:0046133)12.1805547
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509111.6349946
100DNA deamination (GO:0045006)10.9841777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.64511767
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.60638177
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.59144729
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.21986722
5ELF1_17652178_ChIP-ChIP_JURKAT_Human4.04418877
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.83957669
7GATA1_22025678_ChIP-Seq_K562_Human3.76563616
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.64763836
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.20007139
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.03675083
11RUNX_20019798_ChIP-Seq_JUKART_Human2.93029522
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92953078
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48144690
14MYB_26560356_Chip-Seq_TH2_Human2.46778230
15GATA3_27048872_Chip-Seq_THYMUS_Human2.22630730
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02305497
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01272683
18BP1_19119308_ChIP-ChIP_Hs578T_Human11.5345275
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90757112
20GATA3_26560356_Chip-Seq_TH2_Human1.88158195
21MYB_26560356_Chip-Seq_TH1_Human1.85007221
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64717621
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61267581
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38940378
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38680937
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.35022691
27MAF_26560356_Chip-Seq_TH2_Human1.34784415
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.34423595
29MAF_26560356_Chip-Seq_TH1_Human1.27984098
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.25549851
31TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24195231
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.18960718
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17268485
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15599510
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15293709
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13421325
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10000308
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09867346
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06601734
40SPI1_23547873_ChIP-Seq_NB4_Human1.06318498
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05513521
42BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02890371
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99374649
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98253674
45UTX_26944678_Chip-Seq_JUKART_Human0.97063930
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96281584
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96281584
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96281584
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95248277
50PRDM14_20953172_ChIP-Seq_ESCs_Human0.94660231
51VDR_23849224_ChIP-Seq_CD4+_Human0.94593911
52NFE2_27457419_Chip-Seq_LIVER_Mouse0.94281568
53ZNF263_19887448_ChIP-Seq_K562_Human0.93703865
54GATA3_26560356_Chip-Seq_TH1_Human0.91428188
55EST1_17652178_ChIP-ChIP_JURKAT_Human0.90537264
56CTCF_20526341_ChIP-Seq_ESCs_Human0.89184659
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88263862
58SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87564646
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85292198
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84706796
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83947430
62HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83642933
63YY1_22570637_ChIP-Seq_MALME-3M_Human0.83412245
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82974038
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80954702
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80338221
67BCL6_27268052_Chip-Seq_Bcells_Human0.78760831
68HTT_18923047_ChIP-ChIP_STHdh_Human0.78481335
69VDR_24787735_ChIP-Seq_THP-1_Human0.78407409
70EZH2_27294783_Chip-Seq_NPCs_Mouse0.77959725
71TP53_22573176_ChIP-Seq_HFKS_Human0.77067729
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77042900
73FOXP3_21729870_ChIP-Seq_TREG_Human0.76955621
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76133883
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.76044162
76SOX2_19829295_ChIP-Seq_ESCs_Human0.75108117
77NANOG_19829295_ChIP-Seq_ESCs_Human0.75108117
78TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.73994309
79FLI1_27457419_Chip-Seq_LIVER_Mouse0.72713180
80GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.71466068
81CIITA_25753668_ChIP-Seq_RAJI_Human0.70563051
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.70480633
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.70074584
84MYC_19829295_ChIP-Seq_ESCs_Human0.69117621
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69051869
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.67794255
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.66720730
88BCAT_22108803_ChIP-Seq_LS180_Human0.66690096
89RUNX1_27457419_Chip-Seq_LIVER_Mouse0.66190233
90P53_21459846_ChIP-Seq_SAOS-2_Human0.66037813
91FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.64238693
92RARB_24833708_ChIP-Seq_LIVER_Mouse0.63024838
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.62946372
94GATA2_22383799_ChIP-Seq_G1ME_Mouse0.61702669
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.61197282
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.60341719
97OCT4_18555785_Chip-Seq_ESCs_Mouse0.60100113
98SA1_27219007_Chip-Seq_Bcells_Human0.59429322
99TAF2_19829295_ChIP-Seq_ESCs_Human0.58483429
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.58221612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001853_heart_inflammation5.60121857
2MP0005671_abnormal_response_to5.05350154
3MP0001873_stomach_inflammation4.76006216
4MP0001835_abnormal_antigen_presentation4.29336895
5MP0003806_abnormal_nucleotide_metabolis3.44389251
6MP0000604_amyloidosis3.36380460
7MP0003300_gastrointestinal_ulcer3.35615177
8MP0000372_irregular_coat_pigmentation3.07290162
9MP0003011_delayed_dark_adaptation3.05948882
10MP0009333_abnormal_splenocyte_physiolog3.02057398
11MP0003763_abnormal_thymus_physiology2.93592450
12MP0002148_abnormal_hypersensitivity_rea2.76970082
13MP0009785_altered_susceptibility_to2.34912927
14MP0005000_abnormal_immune_tolerance2.26377795
15MP0000465_gastrointestinal_hemorrhage2.25803415
16MP0001188_hyperpigmentation2.24951130
17MP0001800_abnormal_humoral_immune2.24846088
18MP0002163_abnormal_gland_morphology2.10401022
19MP0005025_abnormal_response_to2.07334940
20MP0002420_abnormal_adaptive_immunity2.03158517
21MP0001790_abnormal_immune_system2.02108969
22MP0005387_immune_system_phenotype2.02108969
23MP0002933_joint_inflammation1.98482213
24MP0002877_abnormal_melanocyte_morpholog1.97088895
25MP0002723_abnormal_immune_serum1.96709041
26MP0003786_premature_aging1.96521750
27MP0002405_respiratory_system_inflammati1.96128276
28MP0001819_abnormal_immune_cell1.93467852
29MP0005310_abnormal_salivary_gland1.92836397
30MP0000716_abnormal_immune_system1.81393343
31MP0002398_abnormal_bone_marrow1.81096255
32MP0006082_CNS_inflammation1.72061183
33MP0003329_amyloid_beta_deposits1.70536218
34MP0000703_abnormal_thymus_morphology1.69642026
35MP0003866_abnormal_defecation1.64414489
36MP0002102_abnormal_ear_morphology1.63654209
37MP0003448_altered_tumor_morphology1.62552002
38MP0002452_abnormal_antigen_presenting1.54547009
39MP0000685_abnormal_immune_system1.51786934
40MP0002722_abnormal_immune_system1.49234893
41MP0000689_abnormal_spleen_morphology1.44188595
42MP0002396_abnormal_hematopoietic_system1.43809789
43MP0001919_abnormal_reproductive_system1.41698211
44MP0002429_abnormal_blood_cell1.40148781
45MP0010155_abnormal_intestine_physiology1.36250399
46MP0003567_abnormal_fetal_cardiomyocyte1.31382666
47MP0003436_decreased_susceptibility_to1.28447267
48MP0002277_abnormal_respiratory_mucosa1.25909418
49MP0002166_altered_tumor_susceptibility1.24162233
50MP0001845_abnormal_inflammatory_respons1.24131919
51MP0004381_abnormal_hair_follicle1.22142298
52MP0001984_abnormal_olfaction1.19366853
53MP0002006_tumorigenesis1.18135880
54MP0009379_abnormal_foot_pigmentation1.15724936
55MP0005623_abnormal_meninges_morphology1.13085553
56MP0006054_spinal_hemorrhage1.11580974
57MP0008995_early_reproductive_senescence1.08980856
58MP0000490_abnormal_crypts_of1.06497654
59MP0002419_abnormal_innate_immunity1.04418182
60MP0002693_abnormal_pancreas_physiology1.03397136
61MP0002019_abnormal_tumor_incidence0.98582401
62MP0004947_skin_inflammation0.98121706
63MP0008789_abnormal_olfactory_epithelium0.97433660
64MP0008873_increased_physiological_sensi0.94250605
65MP0002234_abnormal_pharynx_morphology0.93015099
66MP0003724_increased_susceptibility_to0.92593906
67MP0002876_abnormal_thyroid_physiology0.90864812
68MP0005379_endocrine/exocrine_gland_phen0.89390524
69MP0001958_emphysema0.88417179
70MP0004808_abnormal_hematopoietic_stem0.79299365
71MP0009765_abnormal_xenobiotic_induced0.76399185
72MP0001533_abnormal_skeleton_physiology0.75596825
73MP0000733_abnormal_muscle_development0.75457217
74MP0009763_increased_sensitivity_to0.73192128
75MP0008469_abnormal_protein_level0.72890421
76MP0002132_abnormal_respiratory_system0.71138276
77MP0000613_abnormal_salivary_gland0.69677185
78MP0004147_increased_porphyrin_level0.68475280
79MP0000858_altered_metastatic_potential0.67077633
80MP0005360_urolithiasis0.66457335
81MP0003959_abnormal_lean_body0.64899973
82MP0008007_abnormal_cellular_replicative0.61216088
83MP0005408_hypopigmentation0.61063936
84MP0005394_taste/olfaction_phenotype0.59651861
85MP0005499_abnormal_olfactory_system0.59651861
86MP0003045_fibrosis0.59575683
87MP0003137_abnormal_impulse_conducting0.59019009
88MP0000249_abnormal_blood_vessel0.58701507
89MP0005389_reproductive_system_phenotype0.57215584
90MP0001663_abnormal_digestive_system0.56841231
91MP0001881_abnormal_mammary_gland0.55643752
92MP0004742_abnormal_vestibular_system0.52964767
93MP0010307_abnormal_tumor_latency0.52837594
94MP0004134_abnormal_chest_morphology0.49293131
95MP0002751_abnormal_autonomic_nervous0.48253390
96MP0003172_abnormal_lysosome_physiology0.48157474
97MP0005253_abnormal_eye_physiology0.47528273
98MP0003183_abnormal_peptide_metabolism0.46852069
99MP0005075_abnormal_melanosome_morpholog0.46060153
100MP0009643_abnormal_urine_homeostasis0.45143830

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.09539333
2T lymphocytopenia (HP:0005403)5.69050311
3Abnormality of T cell number (HP:0011839)5.67955913
4Stomatitis (HP:0010280)4.94240251
5Dysautonomia (HP:0002459)4.73729256
6Oral leukoplakia (HP:0002745)4.70343842
7Autoimmune hemolytic anemia (HP:0001890)4.64816977
8Aplastic anemia (HP:0001915)4.57068834
9Abnormality of the prostate (HP:0008775)4.55869382
10Increased IgM level (HP:0003496)4.39920310
11Ureteral stenosis (HP:0000071)4.25997042
12Pulmonary infiltrates (HP:0002113)4.14886631
13Abnormality of T cells (HP:0002843)4.14515632
14IgG deficiency (HP:0004315)4.12905212
15Ureteral obstruction (HP:0006000)3.84484069
16Chest pain (HP:0100749)3.78239834
17Alveolar cell carcinoma (HP:0006519)3.77457955
18Retrobulbar optic neuritis (HP:0100654)3.73236591
19Optic neuritis (HP:0100653)3.73236591
20Gangrene (HP:0100758)3.69597231
21Hemoptysis (HP:0002105)3.57973146
22Obstructive lung disease (HP:0006536)3.56147661
23Chronic obstructive pulmonary disease (HP:0006510)3.56147661
243-Methylglutaconic aciduria (HP:0003535)3.51751473
25Abnormality of the pleura (HP:0002103)3.44879749
26Pulmonary embolism (HP:0002204)3.43233570
27Pulmonary fibrosis (HP:0002206)3.40441905
28Neoplasm of the tracheobronchial system (HP:0100552)3.29266743
29Abnormality of the pericardium (HP:0001697)3.24733739
30Vasculitis (HP:0002633)3.22461977
31Abnormality of male internal genitalia (HP:0000022)3.21048239
32Hypoproteinemia (HP:0003075)3.17064423
33Orchitis (HP:0100796)3.16888615
34Myositis (HP:0100614)3.10660255
35Meningitis (HP:0001287)3.07261276
36Abnormal delayed hypersensitivity skin test (HP:0002963)3.02605989
37Abnormality of T cell physiology (HP:0011840)3.01939954
38Anhidrosis (HP:0000970)3.01758728
39Carpal bone hypoplasia (HP:0001498)2.96642354
40Severe combined immunodeficiency (HP:0004430)2.76496089
41Spastic paraparesis (HP:0002313)2.72069321
42Increased intramyocellular lipid droplets (HP:0012240)2.70521556
43Severe visual impairment (HP:0001141)2.70465153
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69536516
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69536516
46Arthropathy (HP:0003040)2.63258459
47Abnormality of eosinophils (HP:0001879)2.59533388
48Abnormal autonomic nervous system physiology (HP:0012332)2.56052153
49IgA deficiency (HP:0002720)2.56017023
50Orthostatic hypotension (HP:0001278)2.55163413
51Restrictive lung disease (HP:0002091)2.53438777
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.51720914
53Recurrent bronchitis (HP:0002837)2.48411501
54Lymphopenia (HP:0001888)2.47613605
55Increased muscle lipid content (HP:0009058)2.44761415
56Premature graying of hair (HP:0002216)2.43338221
57Chronic diarrhea (HP:0002028)2.37064536
58Glomerulopathy (HP:0100820)2.36316079
59Keratoconjunctivitis sicca (HP:0001097)2.35514324
60Polyneuropathy (HP:0001271)2.31146806
61Eosinophilia (HP:0001880)2.31000567
62Thrombophlebitis (HP:0004418)2.29377349
63Arterial thrombosis (HP:0004420)2.28723797
64Dysphonia (HP:0001618)2.26968914
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24852548
66Thyroiditis (HP:0100646)2.24424394
67Supernumerary bones of the axial skeleton (HP:0009144)2.21722023
68Abnormality of macrophages (HP:0004311)2.20219401
69Urethral obstruction (HP:0000796)2.14810103
70Keratoconjunctivitis (HP:0001096)2.14725325
71Poor speech (HP:0002465)2.14121348
72Progressive external ophthalmoplegia (HP:0000590)2.12739428
73Cutaneous melanoma (HP:0012056)2.09746945
74Hypergammaglobulinemia (HP:0010702)2.06926765
75Combined immunodeficiency (HP:0005387)2.06815019
76Amyotrophic lateral sclerosis (HP:0007354)2.06417577
77Pigmentary retinal degeneration (HP:0001146)2.02024211
78Recurrent skin infections (HP:0001581)2.01349046
79Leukocytosis (HP:0001974)1.99937752
80Recurrent otitis media (HP:0000403)1.97550838
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94196773
82Conical tooth (HP:0000698)1.93612025
83Gastrointestinal infarctions (HP:0005244)1.93242063
84Pustule (HP:0200039)1.91366111
85Mediastinal lymphadenopathy (HP:0100721)1.91070038
86Joint swelling (HP:0001386)1.90087579
87Recurrent viral infections (HP:0004429)1.89484659
88Autoimmune thrombocytopenia (HP:0001973)1.88173859
89Retinopathy (HP:0000488)1.87438698
90Recurrent bacterial skin infections (HP:0005406)1.84947410
91Paresthesia (HP:0003401)1.83414531
92Keratitis (HP:0000491)1.82919315
93Genetic anticipation (HP:0003743)1.82610061
94Astrocytoma (HP:0009592)1.81771227
95Abnormality of the astrocytes (HP:0100707)1.81771227
96Facial edema (HP:0000282)1.80769451
97J-shaped sella turcica (HP:0002680)1.80320632
98Self-mutilation (HP:0000742)1.78690315
99Lymphoma (HP:0002665)1.76635623
100Pancreatitis (HP:0001733)1.76570908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.66312014
2MST43.05290290
3ITK2.57696100
4CSK2.55625102
5NTRK12.46885033
6MATK2.39901749
7RIPK42.38023626
8MAP4K12.36092402
9MAP2K62.31229385
10SCYL22.25662418
11TAOK32.02931126
12TXK11.7857523
13MAP3K131.96340711
14CAMKK21.87816246
15FES1.74307990
16ADRBK21.70261971
17EIF2AK31.49064929
18LCK1.41623748
19TESK21.24844393
20BMPR1B1.23777842
21IKBKB1.22788590
22TEC1.18990595
23GRK71.14401962
24BMPR21.10545795
25SRPK11.02793936
26TYRO31.00269384
27WNK40.95258524
28BTK0.92436947
29SYK0.91650611
30TESK10.90599236
31CAMKK10.88944397
32PRKCQ0.85553159
33LYN0.84266978
34PINK10.83469573
35FYN0.83208288
36MAP3K90.81414344
37STK390.81078964
38JAK20.79085640
39WNK10.76627519
40OXSR10.70142305
41PASK0.69589540
42GRK10.67416811
43ERBB20.65504239
44FGFR10.65308547
45IRAK40.62270562
46ATR0.62128816
47INSR0.61123882
48BRSK20.58585423
49IKBKE0.58425190
50PAK40.57794607
51IGF1R0.56691262
52DYRK1A0.55489070
53TIE10.53924686
54PAK30.51109591
55HCK0.51012767
56CSF1R0.49297972
57TAOK20.47948744
58ZAP700.47158743
59STK240.47084384
60STK110.46543069
61JAK30.46133498
62TGFBR20.44222347
63RAF10.44169714
64EGFR0.41035025
65PRPF4B0.38282533
66MAP3K140.34869976
67NUAK10.33396990
68AURKA0.32060134
69CAMK10.31300351
70CHUK0.29591336
71ROCK10.28979973
72PDK10.28887087
73FRK0.28428995
74OBSCN0.27628495
75MAPKAPK20.27115365
76INSRR0.25548275
77RPS6KA50.25162016
78CDK40.25129723
79CAMK2A0.22969476
80PRKACA0.20775934
81PDGFRB0.18604904
82GRK60.18075295
83PRKCA0.17851841
84TNK20.15349870
85KIT0.15114497
86MOS0.14397750
87KSR20.14359561
88PRKCZ0.14340207
89RPS6KA40.14255405
90BLK0.14054905
91MUSK0.13780124
92WNK30.13420403
93PRKD10.13094687
94ABL10.12951314
95SRC0.12761087
96CAMK2B0.10407366
97MAPK40.10351923
98MYLK0.09478499
99PDK20.07834959
100MAP2K20.07275552

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.49288943
2Autoimmune thyroid disease_Homo sapiens_hsa053204.82817847
3Graft-versus-host disease_Homo sapiens_hsa053324.34069695
4Proteasome_Homo sapiens_hsa030504.22392797
5Allograft rejection_Homo sapiens_hsa053303.84355357
6T cell receptor signaling pathway_Homo sapiens_hsa046603.41604144
7Hematopoietic cell lineage_Homo sapiens_hsa046403.03649357
8Type I diabetes mellitus_Homo sapiens_hsa049402.77027061
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74850681
10Asthma_Homo sapiens_hsa053102.57044477
11Rheumatoid arthritis_Homo sapiens_hsa053232.43420959
12Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.33189839
13Antigen processing and presentation_Homo sapiens_hsa046122.27339912
14Protein export_Homo sapiens_hsa030602.25055477
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16450806
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06756769
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.98916312
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.83211617
19Salmonella infection_Homo sapiens_hsa051321.73090821
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.70672298
21Measles_Homo sapiens_hsa051621.63683920
22Chemokine signaling pathway_Homo sapiens_hsa040621.43726033
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33498189
24Non-homologous end-joining_Homo sapiens_hsa034501.31113195
25Viral myocarditis_Homo sapiens_hsa054161.17927025
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.16113992
27Selenocompound metabolism_Homo sapiens_hsa004501.11762575
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07557770
29Shigellosis_Homo sapiens_hsa051311.02403646
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96046180
31Regulation of autophagy_Homo sapiens_hsa041400.91331422
32NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89290483
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87179828
34Apoptosis_Homo sapiens_hsa042100.81973470
35Oxidative phosphorylation_Homo sapiens_hsa001900.80594887
36TNF signaling pathway_Homo sapiens_hsa046680.78142156
37African trypanosomiasis_Homo sapiens_hsa051430.71899006
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71543178
39Prion diseases_Homo sapiens_hsa050200.70836882
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68857750
41RNA polymerase_Homo sapiens_hsa030200.66628323
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63148405
43Osteoclast differentiation_Homo sapiens_hsa043800.62340026
44Malaria_Homo sapiens_hsa051440.60150292
45Parkinsons disease_Homo sapiens_hsa050120.54013332
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53936946
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52918934
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.52084863
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51727445
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48681348
51Linoleic acid metabolism_Homo sapiens_hsa005910.48215896
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46585093
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.45704970
54Alzheimers disease_Homo sapiens_hsa050100.45167391
55HTLV-I infection_Homo sapiens_hsa051660.44685601
56Staphylococcus aureus infection_Homo sapiens_hsa051500.44197313
57Epstein-Barr virus infection_Homo sapiens_hsa051690.43545277
58Homologous recombination_Homo sapiens_hsa034400.43022481
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39608409
60Collecting duct acid secretion_Homo sapiens_hsa049660.39485493
61Peroxisome_Homo sapiens_hsa041460.39482250
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39196303
63Systemic lupus erythematosus_Homo sapiens_hsa053220.37310973
64Retinol metabolism_Homo sapiens_hsa008300.37139347
65Ribosome_Homo sapiens_hsa030100.33920479
66Influenza A_Homo sapiens_hsa051640.33136510
67Leishmaniasis_Homo sapiens_hsa051400.31929854
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30515487
69Tuberculosis_Homo sapiens_hsa051520.30065848
70Nitrogen metabolism_Homo sapiens_hsa009100.29186162
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28796185
72Morphine addiction_Homo sapiens_hsa050320.28377398
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25597761
74Endocytosis_Homo sapiens_hsa041440.25308098
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24253690
76VEGF signaling pathway_Homo sapiens_hsa043700.24108533
77Legionellosis_Homo sapiens_hsa051340.23924545
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.22804190
79Ether lipid metabolism_Homo sapiens_hsa005650.22594964
80GABAergic synapse_Homo sapiens_hsa047270.22240243
81Vitamin digestion and absorption_Homo sapiens_hsa049770.21187142
82Folate biosynthesis_Homo sapiens_hsa007900.21009228
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20395459
84Cardiac muscle contraction_Homo sapiens_hsa042600.19229576
85Butanoate metabolism_Homo sapiens_hsa006500.17475352
86MAPK signaling pathway_Homo sapiens_hsa040100.16759933
87Pertussis_Homo sapiens_hsa051330.16113041
88Non-small cell lung cancer_Homo sapiens_hsa052230.14043268
89Serotonergic synapse_Homo sapiens_hsa047260.13703054
90Herpes simplex infection_Homo sapiens_hsa051680.12915405
91Basal transcription factors_Homo sapiens_hsa030220.11284994
92p53 signaling pathway_Homo sapiens_hsa041150.10851887
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09194050
94Viral carcinogenesis_Homo sapiens_hsa052030.08096134
95Olfactory transduction_Homo sapiens_hsa047400.07082466
96Ras signaling pathway_Homo sapiens_hsa040140.06183341
97Pyrimidine metabolism_Homo sapiens_hsa002400.05372821
98Bladder cancer_Homo sapiens_hsa052190.04508573
99Huntingtons disease_Homo sapiens_hsa050160.03497208
100Toxoplasmosis_Homo sapiens_hsa051450.02775731

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