TRAV26-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)9.53794229
2CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)9.07214283
3positive regulation of isotype switching (GO:0045830)8.29393326
4regulation of chronic inflammatory response (GO:0002676)7.92196122
5positive regulation of granulocyte differentiation (GO:0030854)7.63177033
6negative regulation of T-helper cell differentiation (GO:0045623)7.47103247
7negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)7.47103247
8regulation of podosome assembly (GO:0071801)7.25422368
9positive regulation of immunoglobulin production (GO:0002639)7.24292152
10positive regulation of DNA recombination (GO:0045911)7.21243599
11negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.78279722
12T-helper cell differentiation (GO:0042093)6.30613892
13CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)6.30613892
14cytokine production involved in immune response (GO:0002367)6.13199052
15regulation of isotype switching (GO:0045191)5.98145214
16negative T cell selection (GO:0043383)5.77581154
17T cell differentiation involved in immune response (GO:0002292)5.74926435
18alpha-beta T cell differentiation involved in immune response (GO:0002293)5.74926435
19alpha-beta T cell activation involved in immune response (GO:0002287)5.74926435
20regulation of interleukin-13 production (GO:0032656)5.72785317
21negative regulation of nitric oxide biosynthetic process (GO:0045019)5.70736344
22regulation of immunoglobulin secretion (GO:0051023)5.70373482
23T cell lineage commitment (GO:0002360)5.63267492
24regulation of immunoglobulin production (GO:0002637)5.58118824
25positive regulation of chemokine biosynthetic process (GO:0045080)5.55731600
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.37019815
27positive regulation of B cell mediated immunity (GO:0002714)5.32851133
28positive regulation of immunoglobulin mediated immune response (GO:0002891)5.32851133
29negative regulation of alpha-beta T cell differentiation (GO:0046639)5.29468597
30cytidine deamination (GO:0009972)5.22568292
31cytidine metabolic process (GO:0046087)5.22568292
32cytidine catabolic process (GO:0006216)5.22568292
33negative regulation of alpha-beta T cell activation (GO:0046636)5.18816105
34CD4-positive, alpha-beta T cell differentiation (GO:0043367)5.13891057
35regulation of MHC class II biosynthetic process (GO:0045346)5.13493911
36cellular response to interferon-beta (GO:0035458)5.09898887
37regulation of granulocyte differentiation (GO:0030852)5.06956076
38response to mercury ion (GO:0046689)5.04703671
39cellular response to interleukin-15 (GO:0071350)4.93869925
40negative regulation of acute inflammatory response (GO:0002674)4.89300634
41positive T cell selection (GO:0043368)4.85343907
42cytokine biosynthetic process (GO:0042089)4.84720719
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.84362241
44defense response to protozoan (GO:0042832)4.79923654
45pyrimidine ribonucleoside catabolic process (GO:0046133)4.70999078
46CD4-positive, alpha-beta T cell activation (GO:0035710)4.63037741
47response to interleukin-15 (GO:0070672)4.60471001
48T cell mediated immunity (GO:0002456)4.54497394
49alpha-beta T cell differentiation (GO:0046632)4.41038587
50DNA deamination (GO:0045006)4.39767228
51activated T cell proliferation (GO:0050798)4.37581236
52regulation of proton transport (GO:0010155)4.30435178
53regulation of chemokine biosynthetic process (GO:0045073)4.30430741
54cellular defense response (GO:0006968)4.29944647
55positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.26060820
56positive regulation of gamma-delta T cell activation (GO:0046645)4.24580237
57positive regulation of B cell proliferation (GO:0030890)4.20962980
58response to protozoan (GO:0001562)4.14522842
59negative thymic T cell selection (GO:0045060)4.12645005
60positive regulation of interleukin-10 production (GO:0032733)4.10074941
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05334596
62production of molecular mediator of immune response (GO:0002440)4.05282312
63cytokine metabolic process (GO:0042107)4.02577893
64response to interferon-beta (GO:0035456)4.02420856
65antigen processing and presentation via MHC class Ib (GO:0002475)3.97203130
66T cell selection (GO:0045058)3.96468906
67negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.95152309
68regulation of immunoglobulin mediated immune response (GO:0002889)3.95068676
69positive regulation of defense response to virus by host (GO:0002230)3.91705962
70regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.91078713
71positive regulation of B cell activation (GO:0050871)3.86452009
72regulation of B cell mediated immunity (GO:0002712)3.83682943
73positive regulation of production of molecular mediator of immune response (GO:0002702)3.83252463
74alpha-beta T cell activation (GO:0046631)3.76968691
75negative regulation of adaptive immune response (GO:0002820)3.69775038
76positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67542304
77regulation of macrophage activation (GO:0043030)3.62585475
78regulation of B cell proliferation (GO:0030888)3.56646090
79positive regulation of lymphocyte mediated immunity (GO:0002708)3.41622818
80positive regulation of T cell mediated cytotoxicity (GO:0001916)3.36376257
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34496103
82negative regulation of cell killing (GO:0031342)3.34496103
83interferon-gamma production (GO:0032609)3.34280275
84hepatocyte apoptotic process (GO:0097284)3.29066114
85regulation of B cell receptor signaling pathway (GO:0050855)3.28290244
86positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.22368680
87innate immune response in mucosa (GO:0002227)3.19839755
88regulation of B cell activation (GO:0050864)3.16926033
89regulation of gamma-delta T cell differentiation (GO:0045586)3.15583896
90positive regulation of histone H3-K4 methylation (GO:0051571)3.15153142
91establishment of protein localization to mitochondrial membrane (GO:0090151)3.13612318
92regulation of interleukin-2 biosynthetic process (GO:0045076)3.13463707
93negative regulation of T cell mediated immunity (GO:0002710)3.13366972
94negative regulation of interleukin-12 production (GO:0032695)3.09088912
95thymic T cell selection (GO:0045061)3.07128725
96negative regulation of T cell differentiation (GO:0045581)3.05666958
97regulation of T cell mediated cytotoxicity (GO:0001914)3.04720044
98regulation of T cell receptor signaling pathway (GO:0050856)3.04686770
99regulation of T-helper cell differentiation (GO:0045622)3.03943756
100positive regulation of leukocyte mediated immunity (GO:0002705)3.03440577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.89140370
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.02770776
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.65313898
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.24478050
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.29898713
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29541966
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.19580046
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.14718643
9MYB_26560356_Chip-Seq_TH2_Human3.13228611
10RUNX_20019798_ChIP-Seq_JUKART_Human3.12436755
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05651354
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75119799
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.60305247
14GATA3_26560356_Chip-Seq_TH2_Human2.57930779
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48126283
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46405259
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.35485928
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.17232148
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14839980
20MAF_26560356_Chip-Seq_TH1_Human1.94545484
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93882228
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93213675
23MYB_26560356_Chip-Seq_TH1_Human1.91571009
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.85713470
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.82194144
26VDR_23849224_ChIP-Seq_CD4+_Human1.75046474
27GATA3_27048872_Chip-Seq_THYMUS_Human1.71178133
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69860805
29MAF_26560356_Chip-Seq_TH2_Human1.63190743
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61081499
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60880067
32RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.52654653
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52531871
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48008332
35SPI1_23547873_ChIP-Seq_NB4_Human1.46657304
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45341820
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41755835
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38713186
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38032570
40FOXP3_21729870_ChIP-Seq_TREG_Human1.37256936
41UTX_26944678_Chip-Seq_JUKART_Human1.36639740
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35628218
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35206946
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34195573
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32994451
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30814467
47CIITA_25753668_ChIP-Seq_RAJI_Human1.29735673
48HTT_18923047_ChIP-ChIP_STHdh_Human1.28532662
49ELK1_19687146_ChIP-ChIP_HELA_Human1.27139642
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.23552654
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22723636
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22533301
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20769323
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20101511
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.19922649
56TAF15_26573619_Chip-Seq_HEK293_Human1.19007060
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18896559
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17589188
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14205029
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11659473
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10079482
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.08044346
63NANOG_20526341_ChIP-Seq_ESCs_Human1.07806111
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04276335
65VDR_22108803_ChIP-Seq_LS180_Human1.03903508
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03244202
67BCOR_27268052_Chip-Seq_Bcells_Human1.03137083
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.02425971
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01356671
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99877255
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99134021
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98750337
73BCAT_22108803_ChIP-Seq_LS180_Human0.98059227
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97236687
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97166946
76GATA3_26560356_Chip-Seq_TH1_Human0.97157819
77SRF_21415370_ChIP-Seq_HL-1_Mouse0.97007166
78ERG_20517297_ChIP-Seq_VCAP_Human0.96275589
79TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95637072
80TP53_22573176_ChIP-Seq_HFKS_Human0.92501901
81PRDM14_20953172_ChIP-Seq_ESCs_Human0.90694216
82BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.90558865
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89868827
84CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89761470
85FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89335867
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88915765
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88063707
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87365135
89SPI1_23127762_ChIP-Seq_K562_Human0.86931253
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85729834
91MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85711005
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84493400
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84024189
94LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83506508
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83237101
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80378306
97ERA_21632823_ChIP-Seq_H3396_Human0.79968188
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78277508
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75154777
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.74197309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland6.42681208
2MP0001873_stomach_inflammation5.78350201
3MP0008057_abnormal_DNA_replication4.54904231
4MP0005671_abnormal_response_to4.45136741
5MP0003763_abnormal_thymus_physiology4.34123702
6MP0001835_abnormal_antigen_presentation3.96634099
7MP0006082_CNS_inflammation3.92490493
8MP0000685_abnormal_immune_system3.27344568
9MP0005387_immune_system_phenotype3.12522246
10MP0001790_abnormal_immune_system3.12522246
11MP0005310_abnormal_salivary_gland2.63950873
12MP0001800_abnormal_humoral_immune2.49123119
13MP0009333_abnormal_splenocyte_physiolog2.47967321
14MP0001853_heart_inflammation2.39588579
15MP0008875_abnormal_xenobiotic_pharmacok2.39223093
16MP0005000_abnormal_immune_tolerance2.18963471
17MP0003866_abnormal_defecation2.04363133
18MP0008872_abnormal_physiological_respon2.02622917
19MP0005025_abnormal_response_to2.01092829
20MP0002166_altered_tumor_susceptibility1.99113010
21MP0003436_decreased_susceptibility_to1.98556768
22MP0003191_abnormal_cellular_cholesterol1.93911788
23MP0009840_abnormal_foam_cell1.93138447
24MP0002723_abnormal_immune_serum1.92259889
25MP0002420_abnormal_adaptive_immunity1.73959342
26MP0001819_abnormal_immune_cell1.69312550
27MP0002837_dystrophic_cardiac_calcinosis1.66483157
28MP0003878_abnormal_ear_physiology1.62083620
29MP0005377_hearing/vestibular/ear_phenot1.62083620
30MP0000703_abnormal_thymus_morphology1.62011703
31MP0002452_abnormal_antigen_presenting1.58905565
32MP0009278_abnormal_bone_marrow1.54603697
33MP0003300_gastrointestinal_ulcer1.52939966
34MP0004084_abnormal_cardiac_muscle1.51892879
35MP0002653_abnormal_ependyma_morphology1.49723057
36MP0002148_abnormal_hypersensitivity_rea1.47740010
37MP0003045_fibrosis1.46711196
38MP0000716_abnormal_immune_system1.43819844
39MP0002009_preneoplasia1.39303157
40MP0001663_abnormal_digestive_system1.37763796
41MP0004036_abnormal_muscle_relaxation1.37353935
42MP0002398_abnormal_bone_marrow1.35289118
43MP0002138_abnormal_hepatobiliary_system1.34328482
44MP0002006_tumorigenesis1.34147651
45MP0009785_altered_susceptibility_to1.30105723
46MP0010155_abnormal_intestine_physiology1.30073205
47MP0002419_abnormal_innate_immunity1.29906507
48MP0002405_respiratory_system_inflammati1.26238413
49MP0000689_abnormal_spleen_morphology1.17434467
50MP0002722_abnormal_immune_system1.17352166
51MP0008469_abnormal_protein_level1.13772532
52MP0002429_abnormal_blood_cell1.11895221
53MP0004142_abnormal_muscle_tone1.11268653
54MP0004381_abnormal_hair_follicle1.09593222
55MP0002277_abnormal_respiratory_mucosa1.07101167
56MP0008775_abnormal_heart_ventricle1.03620976
57MP0000858_altered_metastatic_potential1.01105461
58MP0001845_abnormal_inflammatory_respons1.00082665
59MP0010352_gastrointestinal_tract_polyps0.94682570
60MP0002736_abnormal_nociception_after0.86060957
61MP0005381_digestive/alimentary_phenotyp0.85733196
62MP0001533_abnormal_skeleton_physiology0.85333761
63MP0001765_abnormal_ion_homeostasis0.84990512
64MP0002693_abnormal_pancreas_physiology0.81311485
65MP0005584_abnormal_enzyme/coenzyme_acti0.79482841
66MP0005319_abnormal_enzyme/_coenzyme0.79323818
67MP0001968_abnormal_touch/_nociception0.76925053
68MP0003303_peritoneal_inflammation0.76783052
69MP0005464_abnormal_platelet_physiology0.74922637
70MP0002998_abnormal_bone_remodeling0.74529148
71MP0002163_abnormal_gland_morphology0.74079889
72MP0009763_increased_sensitivity_to0.72810827
73MP0005166_decreased_susceptibility_to0.72770357
74MP0003448_altered_tumor_morphology0.72612565
75MP0003880_abnormal_central_pattern0.71038838
76MP0003646_muscle_fatigue0.67260017
77MP0003959_abnormal_lean_body0.65408982
78MP0005379_endocrine/exocrine_gland_phen0.63190305
79MP0002933_joint_inflammation0.61796380
80MP0000477_abnormal_intestine_morphology0.61366068
81MP0005448_abnormal_energy_balance0.59156914
82MP0001986_abnormal_taste_sensitivity0.57917406
83MP0005167_abnormal_blood-brain_barrier0.55953243
84MP0005075_abnormal_melanosome_morpholog0.55858478
85MP0004947_skin_inflammation0.54721237
86MP0003186_abnormal_redox_activity0.53703506
87MP0009764_decreased_sensitivity_to0.51266462
88MP0003724_increased_susceptibility_to0.51217741
89MP0002019_abnormal_tumor_incidence0.51060790
90MP0005636_abnormal_mineral_homeostasis0.50527885
91MP0004215_abnormal_myocardial_fiber0.48313893
92MP0009765_abnormal_xenobiotic_induced0.47675270
93MP0005266_abnormal_metabolism0.46901990
94MP0000569_abnormal_digit_pigmentation0.46498882
95MP0002168_other_aberrant_phenotype0.43048901
96MP0002254_reproductive_system_inflammat0.42912342
97MP0004742_abnormal_vestibular_system0.42576299
98MP0003786_premature_aging0.42505649
99MP0008873_increased_physiological_sensi0.41703420
100MP0006035_abnormal_mitochondrial_morpho0.40220918

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.98975194
2Recurrent cutaneous fungal infections (HP:0011370)5.62137857
3Chronic mucocutaneous candidiasis (HP:0002728)5.62137857
4Stomatitis (HP:0010280)5.60174490
5T lymphocytopenia (HP:0005403)5.36292052
6IgG deficiency (HP:0004315)4.79453334
7Abnormality of T cell number (HP:0011839)4.75630752
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.67770357
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.61943098
10Severe combined immunodeficiency (HP:0004430)4.54181521
11Agammaglobulinemia (HP:0004432)4.49539471
12Recurrent fungal infections (HP:0002841)4.48650606
13Abnormality of T cells (HP:0002843)4.43880491
14Eczematoid dermatitis (HP:0000976)4.42698254
15Panhypogammaglobulinemia (HP:0003139)4.36450390
16Recurrent bronchitis (HP:0002837)3.78941449
17Abnormality of eosinophils (HP:0001879)3.76233735
18Increased IgE level (HP:0003212)3.55930168
19Combined immunodeficiency (HP:0005387)3.51666166
20Thyroiditis (HP:0100646)3.51217742
21Chronic diarrhea (HP:0002028)3.50779127
22Hypoplasia of the thymus (HP:0000778)3.47342184
23Pigmentary retinal degeneration (HP:0001146)3.32154657
24Leukocytosis (HP:0001974)3.30250121
25Large for gestational age (HP:0001520)3.23882966
26Pustule (HP:0200039)3.20058817
27Aplastic anemia (HP:0001915)3.19597509
28Fatigue (HP:0012378)3.10459349
29Colitis (HP:0002583)3.08584092
30Petechiae (HP:0000967)3.05366418
31Recurrent skin infections (HP:0001581)2.95719287
32Encephalitis (HP:0002383)2.92122058
33Abnormality of T cell physiology (HP:0011840)2.88548759
34J-shaped sella turcica (HP:0002680)2.85323954
35Eosinophilia (HP:0001880)2.81750310
36Central scotoma (HP:0000603)2.78156236
37Increased hepatocellular lipid droplets (HP:0006565)2.67092702
38Pulmonary infiltrates (HP:0002113)2.53715297
39Recurrent viral infections (HP:0004429)2.52564097
40Inflammation of the large intestine (HP:0002037)2.51782962
41Hypoplasia of the fovea (HP:0007750)2.50371957
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.50371957
43Abnormal rod and cone electroretinograms (HP:0008323)2.50354095
44Granulocytopenia (HP:0001913)2.48211011
45Congenital stationary night blindness (HP:0007642)2.44143871
46Increased IgM level (HP:0003496)2.41247549
47Progressive microcephaly (HP:0000253)2.39658830
48Bronchitis (HP:0012387)2.37007291
49Limb hypertonia (HP:0002509)2.35959557
50Vasculitis (HP:0002633)2.35417774
51Interstitial pulmonary disease (HP:0006530)2.32440594
52Radial bowing (HP:0002986)2.30966825
53Lipid accumulation in hepatocytes (HP:0006561)2.27784276
54Persistence of primary teeth (HP:0006335)2.27035729
55Hypoplasia of the ulna (HP:0003022)2.26925875
56Myositis (HP:0100614)2.26508295
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26330753
58Decreased circulating renin level (HP:0003351)2.26276317
59Gastrointestinal inflammation (HP:0004386)2.26258071
60Prolonged neonatal jaundice (HP:0006579)2.23366432
61Basal ganglia calcification (HP:0002135)2.22496599
62Hypoproteinemia (HP:0003075)2.22120912
63Meningitis (HP:0001287)2.19706638
64Purpura (HP:0000979)2.15285629
65Poor head control (HP:0002421)2.14908785
66Aplasia/Hypoplasia of the ulna (HP:0006495)2.12668299
67Optic neuritis (HP:0100653)2.11763646
68Retrobulbar optic neuritis (HP:0100654)2.11763646
69Autoimmune hemolytic anemia (HP:0001890)2.10272217
70Carpal bone hypoplasia (HP:0001498)2.07666655
71Exertional dyspnea (HP:0002875)2.07182870
72Micronodular cirrhosis (HP:0001413)2.07137395
73Viral hepatitis (HP:0006562)2.06679209
74Systemic lupus erythematosus (HP:0002725)2.05706550
75Lymphoma (HP:0002665)2.03787243
76Abnormality of the fovea (HP:0000493)2.03315924
77Villous atrophy (HP:0011473)2.02212496
78Abnormality of small intestinal villus morphology (HP:0011472)2.02212496
79Fibular aplasia (HP:0002990)2.00294399
80Hemorrhage of the eye (HP:0011885)2.00155788
81Aplasia/Hypoplasia of the macula (HP:0008059)1.99280120
82Abnormality of the pleura (HP:0002103)1.98013987
83Forearm undergrowth (HP:0009821)1.96414951
84Microcytic anemia (HP:0001935)1.94898309
85Hypoalbuminemia (HP:0003073)1.94431880
86Abnormal albumin level (HP:0012116)1.94431880
87Constricted visual fields (HP:0001133)1.94431340
88Increased serum lactate (HP:0002151)1.90538528
89Dyschromatopsia (HP:0007641)1.90444966
90Orchitis (HP:0100796)1.89443168
91Aortic regurgitation (HP:0001659)1.88746372
92Abnormality of the pericardium (HP:0001697)1.88342417
93Stomach cancer (HP:0012126)1.86940638
94Aplasia/Hypoplasia affecting the retina (HP:0008061)1.85099095
95Lymphopenia (HP:0001888)1.82137621
96Hypergammaglobulinemia (HP:0010702)1.80000343
97Abnormality of the pons (HP:0007361)1.79516722
98Paralysis (HP:0003470)1.79239334
99Increased CSF lactate (HP:0002490)1.76677889
100Respiratory difficulties (HP:0002880)1.72871156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.83529257
2EPHA35.55826191
3PBK5.17640295
4MAP4K13.71670919
5MUSK3.58884351
6EPHB13.54668947
7FGFR43.12042771
8NLK3.07712203
9IRAK42.71670192
10BRD42.05304219
11IRAK11.99656805
12ITK1.84968738
13FGFR31.83626246
14MAP2K31.75557337
15ADRBK21.70767128
16MAP3K31.64666844
17MST41.60385158
18FES1.60297252
19TLK11.48721063
20SRPK11.47602976
21CSK1.47352903
22ZAP701.44211673
23RPS6KA41.25700187
24HCK1.23791051
25PIK3CG1.20606009
26BTK1.18377568
27AKT31.14325889
28NME11.08836571
29TSSK61.06332488
30HIPK21.03413237
31SGK21.01650543
32SYK0.99649528
33STK40.97126830
34JAK10.96923008
35ZAK0.96788453
36LCK0.95938967
37SGK30.92451478
38VRK20.90938477
39PTK2B0.89830128
40TAOK30.89680666
41MAPK120.89214624
42RPS6KA50.88647016
43IKBKB0.86574804
44TNK20.80850448
45WNK40.80540527
46DYRK30.79766810
47MAP3K10.77005224
48JAK30.75370208
49TEC0.70772722
50EIF2AK10.66223241
51SGK2230.65446526
52SGK4940.65446526
53KDR0.63229500
54ALK0.62677557
55TYK20.62011534
56TNIK0.61286162
57MAP3K110.57604066
58GRK70.54284787
59DYRK20.51915147
60IKBKE0.50384827
61MAPKAPK20.50239036
62FER0.48713621
63DAPK20.46264200
64RET0.44998706
65LYN0.44992253
66TGFBR20.43684844
67STK38L0.42083807
68JAK20.40692732
69MAP3K120.36957460
70PRKCQ0.35680190
71CDK80.34913090
72BCKDK0.32093663
73TYRO30.31816640
74TAOK20.30797060
75VRK10.30412311
76CHUK0.29641986
77BLK0.29483624
78WNK10.28826833
79CAMK40.28636099
80MAP2K60.28530727
81NUAK10.28253591
82MAP3K80.28100527
83PIM10.27848614
84GRK60.27326886
85CSF1R0.24407492
86TESK20.23723429
87PRKD30.23614428
88ADRBK10.23269085
89PAK60.21079812
90MYLK0.20033621
91CDK40.18210573
92CLK10.17136931
93TBK10.16684466
94PASK0.15377495
95FGR0.14370425
96EIF2AK30.14330453
97DYRK1B0.11084168
98PRKCH0.09860323
99PDK10.09452381
100GRK10.09204493

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053205.36782974
2Allograft rejection_Homo sapiens_hsa053305.35242969
3Asthma_Homo sapiens_hsa053104.88661271
4Primary immunodeficiency_Homo sapiens_hsa053404.49103096
5Intestinal immune network for IgA production_Homo sapiens_hsa046724.30936313
6Antigen processing and presentation_Homo sapiens_hsa046123.96459946
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.69617347
8T cell receptor signaling pathway_Homo sapiens_hsa046603.42105658
9Hematopoietic cell lineage_Homo sapiens_hsa046402.65221380
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.57194418
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.55578098
12Measles_Homo sapiens_hsa051622.03253110
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94978603
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.94927515
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77405288
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.68114534
17Graft-versus-host disease_Homo sapiens_hsa053321.64512246
18RNA polymerase_Homo sapiens_hsa030201.41236529
19Type I diabetes mellitus_Homo sapiens_hsa049401.24943137
20Proteasome_Homo sapiens_hsa030501.15735690
21Leishmaniasis_Homo sapiens_hsa051401.14133678
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05412285
23Basal transcription factors_Homo sapiens_hsa030221.05101706
24Chemokine signaling pathway_Homo sapiens_hsa040620.97499019
25Ribosome_Homo sapiens_hsa030100.92537455
26Protein export_Homo sapiens_hsa030600.87559445
27Malaria_Homo sapiens_hsa051440.80307939
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78937124
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78578565
30Oxidative phosphorylation_Homo sapiens_hsa001900.78226772
31Collecting duct acid secretion_Homo sapiens_hsa049660.77578073
32Viral carcinogenesis_Homo sapiens_hsa052030.73912521
33Osteoclast differentiation_Homo sapiens_hsa043800.67774142
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66749813
35RNA degradation_Homo sapiens_hsa030180.63979082
36TNF signaling pathway_Homo sapiens_hsa046680.63711151
37Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62866474
38Acute myeloid leukemia_Homo sapiens_hsa052210.59638113
39Rheumatoid arthritis_Homo sapiens_hsa053230.57339821
40Viral myocarditis_Homo sapiens_hsa054160.56273086
41Epstein-Barr virus infection_Homo sapiens_hsa051690.55637964
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55570231
43Toxoplasmosis_Homo sapiens_hsa051450.55416215
44Parkinsons disease_Homo sapiens_hsa050120.55314094
45Platelet activation_Homo sapiens_hsa046110.54734256
46Spliceosome_Homo sapiens_hsa030400.49298998
47Phototransduction_Homo sapiens_hsa047440.46720536
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46473500
49HTLV-I infection_Homo sapiens_hsa051660.46108492
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45034656
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42371131
52RNA transport_Homo sapiens_hsa030130.42065149
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38052997
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37792456
55Regulation of autophagy_Homo sapiens_hsa041400.36695435
56Herpes simplex infection_Homo sapiens_hsa051680.34973910
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33082496
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.32265180
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.31526408
60mTOR signaling pathway_Homo sapiens_hsa041500.31434939
61Pancreatic cancer_Homo sapiens_hsa052120.31008223
62Nitrogen metabolism_Homo sapiens_hsa009100.30642833
63Linoleic acid metabolism_Homo sapiens_hsa005910.30339987
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30246841
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29539631
66Renin secretion_Homo sapiens_hsa049240.28879351
67HIF-1 signaling pathway_Homo sapiens_hsa040660.28174543
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28122265
69Hepatitis C_Homo sapiens_hsa051600.27389292
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27362634
71Huntingtons disease_Homo sapiens_hsa050160.27103914
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.27075551
73Tuberculosis_Homo sapiens_hsa051520.26523887
74Shigellosis_Homo sapiens_hsa051310.25686981
75Apoptosis_Homo sapiens_hsa042100.24601238
76Insulin resistance_Homo sapiens_hsa049310.24393577
77VEGF signaling pathway_Homo sapiens_hsa043700.24366607
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24275963
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.22952740
80Glycerolipid metabolism_Homo sapiens_hsa005610.21531332
81Sulfur metabolism_Homo sapiens_hsa009200.20290387
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20039422
83Galactose metabolism_Homo sapiens_hsa000520.19846896
84Circadian rhythm_Homo sapiens_hsa047100.19014454
85Hepatitis B_Homo sapiens_hsa051610.18893502
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17975003
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.17329007
88Morphine addiction_Homo sapiens_hsa050320.16852525
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16807385
90One carbon pool by folate_Homo sapiens_hsa006700.15811299
91Arachidonic acid metabolism_Homo sapiens_hsa005900.15648143
92Pertussis_Homo sapiens_hsa051330.13976961
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12510409
94Fatty acid biosynthesis_Homo sapiens_hsa000610.11745554
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.11114132
96Mismatch repair_Homo sapiens_hsa034300.10129263
97Ovarian steroidogenesis_Homo sapiens_hsa049130.09397528
98Staphylococcus aureus infection_Homo sapiens_hsa051500.07090670
99Pyrimidine metabolism_Homo sapiens_hsa002400.05936120
100Influenza A_Homo sapiens_hsa051640.05480648

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