TRAV27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.66365708
2cytidine catabolic process (GO:0006216)9.66365708
3cytidine deamination (GO:0009972)9.66365708
4eosinophil chemotaxis (GO:0048245)8.90710165
5pyrimidine ribonucleoside catabolic process (GO:0046133)8.51595474
6regulation of chronic inflammatory response (GO:0002676)8.08868937
7eosinophil migration (GO:0072677)8.02437872
8DNA deamination (GO:0045006)7.93960166
9negative regulation by host of viral transcription (GO:0043922)7.85203962
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.67126393
11monocyte chemotaxis (GO:0002548)7.11552814
12regulation of activation of Janus kinase activity (GO:0010533)7.01731304
13positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.65862584
14positive regulation of natural killer cell mediated immunity (GO:0002717)6.63089567
15negative regulation of T cell apoptotic process (GO:0070233)6.55272265
16regulation of regulatory T cell differentiation (GO:0045589)6.43880967
17regulation of chemokine-mediated signaling pathway (GO:0070099)6.38269822
18macrophage chemotaxis (GO:0048246)6.17793198
19positive regulation of monocyte chemotaxis (GO:0090026)6.12672335
20regulation of lymphocyte chemotaxis (GO:1901623)6.05754578
21positive regulation of T cell apoptotic process (GO:0070234)5.90248355
22regulation of mononuclear cell migration (GO:0071675)5.87456207
23regulation of T cell chemotaxis (GO:0010819)5.83914373
24positive regulation of T cell chemotaxis (GO:0010820)5.83914373
25cellular response to interleukin-15 (GO:0071350)5.73073818
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.51838912
27regulation of natural killer cell mediated immunity (GO:0002715)5.51838912
28positive regulation of interleukin-8 secretion (GO:2000484)5.29192347
29regulation of macrophage chemotaxis (GO:0010758)5.27487574
30response to interleukin-15 (GO:0070672)5.21231922
31positive regulation of translational initiation (GO:0045948)5.04820752
32Arp2/3 complex-mediated actin nucleation (GO:0034314)4.79159675
33positive thymic T cell selection (GO:0045059)4.74745665
34dendritic cell chemotaxis (GO:0002407)4.68724613
35positive regulation of lymphocyte apoptotic process (GO:0070230)4.63698241
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.57758112
37positive regulation of lymphocyte migration (GO:2000403)4.51780256
38positive regulation of calcium-mediated signaling (GO:0050850)4.44836042
39regulation of T cell apoptotic process (GO:0070232)4.43977515
40negative regulation of lymphocyte apoptotic process (GO:0070229)4.41160761
41negative regulation of viral transcription (GO:0032897)4.40367821
42regulation of T cell tolerance induction (GO:0002664)4.39665242
43modulation by host of viral transcription (GO:0043921)4.38347998
44modulation by host of symbiont transcription (GO:0052472)4.38347998
45positive regulation of gamma-delta T cell activation (GO:0046645)4.36934809
46regulation of interleukin-2 biosynthetic process (GO:0045076)4.27468003
47negative regulation of B cell proliferation (GO:0030889)4.24487549
48regulation of interleukin-12 biosynthetic process (GO:0045075)4.18486457
49positive T cell selection (GO:0043368)4.17735480
50modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.17555687
51negative regulation of viral genome replication (GO:0045071)4.15151640
52regulation of monocyte chemotaxis (GO:0090025)4.09463958
53positive regulation of cell killing (GO:0031343)4.08277108
54regulation of gamma-delta T cell differentiation (GO:0045586)4.06970286
55regulation of leukocyte mediated cytotoxicity (GO:0001910)4.06190017
56granulocyte activation (GO:0036230)4.04749435
57actin nucleation (GO:0045010)4.01150829
58positive regulation of tolerance induction (GO:0002645)3.97979557
59pyrimidine nucleoside catabolic process (GO:0046135)3.89779921
60positive regulation of leukocyte apoptotic process (GO:2000108)3.84542162
61T cell costimulation (GO:0031295)3.81387596
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80755054
63lymphocyte costimulation (GO:0031294)3.76439151
64dendritic cell migration (GO:0036336)3.70241863
65regulation of cell killing (GO:0031341)3.70215070
66regulation of interleukin-8 secretion (GO:2000482)3.66162541
67nucleoside diphosphate catabolic process (GO:0009134)3.63808332
68T cell migration (GO:0072678)3.58231408
69membrane raft organization (GO:0031579)3.57422153
70regulation of tolerance induction (GO:0002643)3.53825149
71thymic T cell selection (GO:0045061)3.53643076
72regulation of lymphocyte migration (GO:2000401)3.51759605
73activated T cell proliferation (GO:0050798)3.49306242
74negative regulation of B cell activation (GO:0050869)3.46051660
75positive regulation of T cell migration (GO:2000406)3.44030480
76regulation of gamma-delta T cell activation (GO:0046643)3.41553433
77positive regulation of B cell differentiation (GO:0045579)3.40070069
78negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.38589661
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38248544
80negative regulation of T cell receptor signaling pathway (GO:0050860)3.35476192
81negative regulation of leukocyte apoptotic process (GO:2000107)3.35425456
82neutrophil activation (GO:0042119)3.31029900
83regulation of homotypic cell-cell adhesion (GO:0034110)3.29082614
84regulation of calcium-mediated signaling (GO:0050848)3.28795909
85positive regulation of cell adhesion mediated by integrin (GO:0033630)3.28234741
86T cell receptor signaling pathway (GO:0050852)3.27045929
87positive regulation of smooth muscle cell migration (GO:0014911)3.24494762
88regulation of T cell receptor signaling pathway (GO:0050856)3.24298353
89regulation of T cell migration (GO:2000404)3.22537231
90regulation of lymphocyte apoptotic process (GO:0070228)3.20236350
91T cell mediated immunity (GO:0002456)3.19312760
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16991481
93negative T cell selection (GO:0043383)3.09744256
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07206379
95modification by host of symbiont morphology or physiology (GO:0051851)3.05370823
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01128540
97negative regulation of T cell activation (GO:0050868)2.98735519
98regulation of B cell differentiation (GO:0045577)2.98494010
99regulation of B cell receptor signaling pathway (GO:0050855)2.98337108
100localization within membrane (GO:0051668)2.97471477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.53691926
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.94841077
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.92525226
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.81950209
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.71576889
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.35576412
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.29478004
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.20208072
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.08544184
10MYB_26560356_Chip-Seq_TH2_Human2.93501984
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71964698
12RUNX_20019798_ChIP-Seq_JUKART_Human2.47860725
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42156908
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28390867
15GATA3_27048872_Chip-Seq_THYMUS_Human2.26912675
16MYB_26560356_Chip-Seq_TH1_Human2.10985128
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04802731
18MAF_26560356_Chip-Seq_TH2_Human2.02240161
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00519988
20BP1_19119308_ChIP-ChIP_Hs578T_Human11.2857960
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93579000
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91238646
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85965586
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82172340
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78252409
26UTX_26944678_Chip-Seq_JUKART_Human1.72793691
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71003074
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64972643
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56302843
30MAF_26560356_Chip-Seq_TH1_Human1.55073067
31GATA3_26560356_Chip-Seq_TH2_Human1.54974331
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50933667
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.48552621
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.45686054
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42153461
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42049467
37HTT_18923047_ChIP-ChIP_STHdh_Human1.41425619
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.39471956
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37786643
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32635590
41TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.31567306
42VDR_22108803_ChIP-Seq_LS180_Human1.30511174
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22160552
44VDR_23849224_ChIP-Seq_CD4+_Human1.21463430
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17027775
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16925796
47CIITA_25753668_ChIP-Seq_RAJI_Human1.16498019
48SPI1_23547873_ChIP-Seq_NB4_Human1.10629154
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09271877
50FOXP3_21729870_ChIP-Seq_TREG_Human1.03789707
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00876612
52GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00564017
53TAF2_19829295_ChIP-Seq_ESCs_Human1.00343485
54GATA3_26560356_Chip-Seq_TH1_Human0.99452462
55EST1_17652178_ChIP-ChIP_JURKAT_Human0.96816813
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.95603504
57TAF15_26573619_Chip-Seq_HEK293_Human0.94930937
58TP53_22573176_ChIP-Seq_HFKS_Human0.93783208
59IGF1R_20145208_ChIP-Seq_DFB_Human0.93705458
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92565438
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90877896
62HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90084485
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89093751
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88868426
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87001307
66PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84504240
67P300_27268052_Chip-Seq_Bcells_Human0.84125622
68ELF1_20517297_ChIP-Seq_JURKAT_Human0.82477739
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80308304
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80069193
71RBPJ_21746931_ChIP-Seq_IB4_Human0.79900830
72STAT1_20625510_ChIP-Seq_HELA_Human0.78563503
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77400822
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76736683
75ETS1_20019798_ChIP-Seq_JURKAT_Human0.76361591
76SA1_27219007_Chip-Seq_Bcells_Human0.75318261
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74478065
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.74417296
79BCL6_27268052_Chip-Seq_Bcells_Human0.74308653
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74009665
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73951839
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73544274
83FLI1_21867929_ChIP-Seq_CD8_Mouse0.73500280
84CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.73145792
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.71501351
86NANOG_19829295_ChIP-Seq_ESCs_Human0.71226679
87SOX2_19829295_ChIP-Seq_ESCs_Human0.71226679
88NANOG_20526341_ChIP-Seq_ESCs_Human0.70564864
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69914785
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.69223868
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68703165
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68375576
93PHF8_20622853_ChIP-Seq_HELA_Human0.68164810
94HNFA_21074721_ChIP-Seq_CACO-2_Human0.67523924
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.65159409
96BCOR_27268052_Chip-Seq_Bcells_Human0.63645234
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63608791
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.62992093
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.62733960
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.62217193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.59225614
2MP0003763_abnormal_thymus_physiology3.93794447
3MP0006082_CNS_inflammation3.58142897
4MP0009333_abnormal_splenocyte_physiolog3.48785340
5MP0009785_altered_susceptibility_to3.37741411
6MP0001873_stomach_inflammation3.08828138
7MP0004145_abnormal_muscle_electrophysio3.04514310
8MP0002148_abnormal_hypersensitivity_rea2.75433789
9MP0001800_abnormal_humoral_immune2.68866206
10MP0005000_abnormal_immune_tolerance2.63062129
11MP0003045_fibrosis2.53864115
12MP0002723_abnormal_immune_serum2.50911256
13MP0001835_abnormal_antigen_presentation2.42496327
14MP0002420_abnormal_adaptive_immunity2.34092256
15MP0003866_abnormal_defecation2.33963128
16MP0001819_abnormal_immune_cell2.27204706
17MP0002163_abnormal_gland_morphology2.24446908
18MP0002405_respiratory_system_inflammati2.22886571
19MP0005025_abnormal_response_to2.17957267
20MP0002638_abnormal_pupillary_reflex2.02395169
21MP0010155_abnormal_intestine_physiology2.01304866
22MP0002398_abnormal_bone_marrow2.00558599
23MP0010307_abnormal_tumor_latency1.98336425
24MP0002877_abnormal_melanocyte_morpholog1.97069317
25MP0002452_abnormal_antigen_presenting1.90354751
26MP0000716_abnormal_immune_system1.87896444
27MP0001790_abnormal_immune_system1.82108099
28MP0005387_immune_system_phenotype1.82108099
29MP0000703_abnormal_thymus_morphology1.78564612
30MP0002933_joint_inflammation1.78542264
31MP0001853_heart_inflammation1.76616372
32MP0001188_hyperpigmentation1.76511950
33MP0002722_abnormal_immune_system1.75816509
34MP0000689_abnormal_spleen_morphology1.73511518
35MP0003878_abnormal_ear_physiology1.69594692
36MP0005377_hearing/vestibular/ear_phenot1.69594692
37MP0003075_altered_response_to1.68973006
38MP0000685_abnormal_immune_system1.67043047
39MP0003786_premature_aging1.62538428
40MP0005464_abnormal_platelet_physiology1.60074208
41MP0000569_abnormal_digit_pigmentation1.56264704
42MP0001845_abnormal_inflammatory_respons1.55463965
43MP0002419_abnormal_innate_immunity1.50013113
44MP0005310_abnormal_salivary_gland1.47585530
45MP0002429_abnormal_blood_cell1.46909062
46MP0005379_endocrine/exocrine_gland_phen1.45629383
47MP0003183_abnormal_peptide_metabolism1.43105661
48MP0004381_abnormal_hair_follicle1.42221148
49MP0003436_decreased_susceptibility_to1.39974915
50MP0005075_abnormal_melanosome_morpholog1.34218359
51MP0002138_abnormal_hepatobiliary_system1.28435133
52MP0003448_altered_tumor_morphology1.26875502
53MP0001905_abnormal_dopamine_level1.24722731
54MP0003646_muscle_fatigue1.15354207
55MP0004147_increased_porphyrin_level1.13814887
56MP0005645_abnormal_hypothalamus_physiol1.12780453
57MP0008469_abnormal_protein_level1.08973147
58MP0000920_abnormal_myelination1.04101933
59MP0003172_abnormal_lysosome_physiology0.98798357
60MP0009764_decreased_sensitivity_to0.96099316
61MP0001661_extended_life_span0.92742549
62MP0003011_delayed_dark_adaptation0.91355660
63MP0005174_abnormal_tail_pigmentation0.89042310
64MP0009765_abnormal_xenobiotic_induced0.87373814
65MP0009763_increased_sensitivity_to0.85966269
66MP0005165_increased_susceptibility_to0.84383854
67MP0002102_abnormal_ear_morphology0.81642572
68MP0001542_abnormal_bone_strength0.81217639
69MP0001984_abnormal_olfaction0.80992697
70MP0004043_abnormal_pH_regulation0.80662494
71MP0002693_abnormal_pancreas_physiology0.77677859
72MP0008873_increased_physiological_sensi0.75580325
73MP0000858_altered_metastatic_potential0.75039969
74MP0004947_skin_inflammation0.73242855
75MP0001502_abnormal_circadian_rhythm0.72242318
76MP0001501_abnormal_sleep_pattern0.71553564
77MP0002277_abnormal_respiratory_mucosa0.70126949
78MP0005670_abnormal_white_adipose0.69887722
79MP0009643_abnormal_urine_homeostasis0.67430058
80MP0001485_abnormal_pinna_reflex0.67228013
81MP0000372_irregular_coat_pigmentation0.66983796
82MP0001243_abnormal_dermal_layer0.63144042
83MP0002019_abnormal_tumor_incidence0.62835178
84MP0000015_abnormal_ear_pigmentation0.62586350
85MP0002166_altered_tumor_susceptibility0.62172707
86MP0004134_abnormal_chest_morphology0.61951076
87MP0005166_decreased_susceptibility_to0.58140976
88MP0008007_abnormal_cellular_replicative0.57430774
89MP0001919_abnormal_reproductive_system0.55982303
90MP0002168_other_aberrant_phenotype0.55975699
91MP0002909_abnormal_adrenal_gland0.53683988
92MP0002136_abnormal_kidney_physiology0.53050964
93MP0002090_abnormal_vision0.51403363
94MP0002006_tumorigenesis0.51216178
95MP0002876_abnormal_thyroid_physiology0.50602552
96MP0003137_abnormal_impulse_conducting0.48699978
97MP0002083_premature_death0.46043934
98MP0000343_altered_response_to0.43124523
99MP0001765_abnormal_ion_homeostasis0.42137257
100MP0005319_abnormal_enzyme/_coenzyme0.41915443

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.81187983
2Abnormality of T cell number (HP:0011839)8.76780335
3Abnormality of T cells (HP:0002843)5.51167424
4Hypoproteinemia (HP:0003075)5.20208386
5Autoimmune hemolytic anemia (HP:0001890)4.96814745
6Aplastic anemia (HP:0001915)4.93055361
7IgG deficiency (HP:0004315)4.89755016
8Increased IgM level (HP:0003496)4.89139731
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.81084787
10Chronic diarrhea (HP:0002028)4.72377225
11Severe combined immunodeficiency (HP:0004430)4.69705929
12Recurrent bronchitis (HP:0002837)4.26302664
13Abnormality of the prostate (HP:0008775)4.10461997
14Recurrent cutaneous fungal infections (HP:0011370)4.04221600
15Chronic mucocutaneous candidiasis (HP:0002728)4.04221600
16Thyroiditis (HP:0100646)3.89611709
17Ureteral stenosis (HP:0000071)3.88452025
18Combined immunodeficiency (HP:0005387)3.72966435
19Abnormality of eosinophils (HP:0001879)3.68810092
20Obstructive lung disease (HP:0006536)3.67566657
21Chronic obstructive pulmonary disease (HP:0006510)3.67566657
22Autoimmune thrombocytopenia (HP:0001973)3.61901209
23Hypoplasia of the thymus (HP:0000778)3.58760805
24Ureteral obstruction (HP:0006000)3.53532058
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32515407
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32515407
27Meningitis (HP:0001287)3.31017757
28Abnormality of macrophages (HP:0004311)3.25524026
29Gangrene (HP:0100758)3.15809710
30Abnormality of T cell physiology (HP:0011840)3.08534261
31Hemiplegia (HP:0002301)3.07662374
32Focal motor seizures (HP:0011153)3.00435910
33Hypoalbuminemia (HP:0003073)2.99379146
34Abnormal albumin level (HP:0012116)2.99379146
35Vasculitis (HP:0002633)2.99334900
36Hemoptysis (HP:0002105)2.93855558
37Encephalitis (HP:0002383)2.93262285
38Pulmonary infiltrates (HP:0002113)2.89005856
39Visual hallucinations (HP:0002367)2.87650802
40Stomatitis (HP:0010280)2.87464265
41Chest pain (HP:0100749)2.87347813
42Elevated erythrocyte sedimentation rate (HP:0003565)2.85095448
43Leukocytosis (HP:0001974)2.83524277
44Recurrent viral infections (HP:0004429)2.82271002
45Agammaglobulinemia (HP:0004432)2.80180381
46Recurrent fungal infections (HP:0002841)2.77277142
47Recurrent skin infections (HP:0001581)2.67260980
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.56879445
49J-shaped sella turcica (HP:0002680)2.56569776
50Abnormality of the pleura (HP:0002103)2.54740675
51Bronchitis (HP:0012387)2.54453143
52Pulmonary fibrosis (HP:0002206)2.52994891
53Joint swelling (HP:0001386)2.46686816
543-Methylglutaconic aciduria (HP:0003535)2.44889630
55Abnormality of B cell number (HP:0010975)2.44712871
56Eosinophilia (HP:0001880)2.43963173
57Granulocytopenia (HP:0001913)2.42992391
58Carpal bone hypoplasia (HP:0001498)2.42050240
59Abnormality of male internal genitalia (HP:0000022)2.37044344
60Pulmonary embolism (HP:0002204)2.36232440
61Myositis (HP:0100614)2.33119759
62Lymphopenia (HP:0001888)2.27139601
63Lymphoma (HP:0002665)2.26903419
64Tetraplegia (HP:0002445)2.25815222
65Zonular cataract (HP:0010920)2.21928897
66Acute necrotizing encephalopathy (HP:0006965)2.21913198
67Pustule (HP:0200039)2.21379497
68Abnormality of the pericardium (HP:0001697)2.17610316
69Recurrent otitis media (HP:0000403)2.15889308
70Periorbital edema (HP:0100539)2.11706285
71Recurrent bacterial skin infections (HP:0005406)2.06722472
72Facial edema (HP:0000282)2.06002572
73Gastrointestinal infarctions (HP:0005244)2.01620444
74Recurrent abscess formation (HP:0002722)2.01273317
75Optic neuritis (HP:0100653)2.01224856
76Retrobulbar optic neuritis (HP:0100654)2.01224856
77Abnormal mitochondria in muscle tissue (HP:0008316)2.00479580
78IgM deficiency (HP:0002850)2.00118295
79Abnormality of the alveolar ridges (HP:0006477)1.99586405
80Skin rash (HP:0000988)1.99153506
81Glomerulopathy (HP:0100820)1.92528425
82Abnormality of liposaccharide metabolism (HP:0010968)1.92407745
83Abnormality of glycosphingolipid metabolism (HP:0004343)1.92407745
84Abnormality of glycolipid metabolism (HP:0010969)1.92407745
85Pancreatitis (HP:0001733)1.88592947
86IgA deficiency (HP:0002720)1.86718214
87Polyneuropathy (HP:0001271)1.84177275
88Mitochondrial inheritance (HP:0001427)1.81589527
89Progressive macrocephaly (HP:0004481)1.79870887
90Panhypogammaglobulinemia (HP:0003139)1.79202891
91Melanoma (HP:0002861)1.78406250
92Retinopathy (HP:0000488)1.76112703
93Acute hepatic failure (HP:0006554)1.74760802
94Abolished electroretinogram (ERG) (HP:0000550)1.73962442
95Cerebral edema (HP:0002181)1.72983756
96Amaurosis fugax (HP:0100576)1.71791407
97Hypergammaglobulinemia (HP:0010702)1.71639513
98Orchitis (HP:0100796)1.70353150
99Abnormality of midbrain morphology (HP:0002418)1.69812822
100Molar tooth sign on MRI (HP:0002419)1.69812822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.97328510
2FES2.61993462
3ITK2.57591558
4MAP4K12.56629333
5MAP3K122.40931390
6BUB12.27996530
7TESK22.09827181
8GRK72.07219471
9PRKCQ2.06376749
10TXK11.7267864
11BCKDK1.89599383
12ADRBK21.89156905
13CSK1.86592065
14MAPKAPK31.75244097
15ZAP701.73717161
16TYRO31.62878760
17SYK1.55098470
18JAK31.54260722
19LCK1.46200891
20SCYL21.37266385
21PIK3CA1.30779734
22IKBKE1.29654292
23MST41.17188470
24TBK11.12951146
25DAPK11.11654930
26TEC1.06745160
27NEK11.00117166
28MAP3K110.99826396
29BTK0.99766918
30ZAK0.97567060
31CLK10.95333907
32MYLK0.94067902
33PASK0.91986063
34LYN0.91225311
35VRK20.88054501
36TRIM280.87266844
37PDGFRB0.86606402
38CSF1R0.82421359
39FYN0.79651813
40RIPK40.73538808
41BLK0.73049147
42PIK3CG0.71589277
43JAK20.71549431
44IKBKB0.69342434
45TAOK30.68014721
46NUAK10.65814203
47WNK40.64830416
48BCR0.60411147
49TNK20.60315601
50LIMK10.57949557
51TESK10.56153698
52MATK0.54020784
53IRAK40.50536452
54EIF2AK30.50044789
55NTRK10.49253728
56IGF1R0.48216004
57MAP3K50.47899070
58PIM20.47820242
59GRK10.46862754
60INSR0.45565213
61TIE10.43270502
62PIM10.40013649
63CAMK2A0.39653967
64DYRK1B0.38773840
65OXSR10.38283112
66CDK190.37984614
67STK100.36715737
68TGFBR20.34608493
69MAPKAPK20.32701232
70VRK10.31991015
71PRKCA0.30713805
72ROCK10.30211055
73FRK0.28719579
74CAMK2G0.28503980
75PRKACA0.28013684
76MAP2K60.27796606
77OBSCN0.27107883
78NLK0.26626128
79INSRR0.25768636
80RPS6KA50.25551178
81HCK0.24438312
82JAK10.24358055
83ATR0.22687155
84FGFR10.22266585
85ADRBK10.21986093
86DAPK30.19242920
87PDK10.18419285
88FGR0.17830604
89SRC0.17232316
90MAPK30.17135070
91CAMK2D0.16614721
92ABL10.16228031
93PAK10.14917516
94PRKCB0.14173397
95MUSK0.12713309
96GRK50.11784741
97GRK60.11615390
98CSNK2A10.11405852
99CSNK1A10.08378697
100MINK10.08289917

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.05308998
2Autoimmune thyroid disease_Homo sapiens_hsa053204.27870326
3Graft-versus-host disease_Homo sapiens_hsa053324.13367829
4Allograft rejection_Homo sapiens_hsa053303.72029036
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.59906552
6Rheumatoid arthritis_Homo sapiens_hsa053233.21544491
7Proteasome_Homo sapiens_hsa030503.20510790
8Type I diabetes mellitus_Homo sapiens_hsa049403.20324779
9Antigen processing and presentation_Homo sapiens_hsa046123.13499707
10T cell receptor signaling pathway_Homo sapiens_hsa046603.02871874
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.99303555
12Hematopoietic cell lineage_Homo sapiens_hsa046402.85693796
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04432112
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.99538739
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.94462908
16Salmonella infection_Homo sapiens_hsa051321.90486749
17Measles_Homo sapiens_hsa051621.89253397
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81028911
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.74644389
20Viral myocarditis_Homo sapiens_hsa054161.67658514
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.64871935
22Prion diseases_Homo sapiens_hsa050201.63522729
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52196807
24Chemokine signaling pathway_Homo sapiens_hsa040621.49381369
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.47925768
26Asthma_Homo sapiens_hsa053101.40636878
27Oxidative phosphorylation_Homo sapiens_hsa001901.35461903
28Parkinsons disease_Homo sapiens_hsa050121.14113892
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12936379
30Malaria_Homo sapiens_hsa051441.06887295
31Staphylococcus aureus infection_Homo sapiens_hsa051501.00190294
32Herpes simplex infection_Homo sapiens_hsa051680.94762773
33TNF signaling pathway_Homo sapiens_hsa046680.93143436
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82260141
35Shigellosis_Homo sapiens_hsa051310.80303735
36Leishmaniasis_Homo sapiens_hsa051400.79678988
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73883846
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73618737
39RNA polymerase_Homo sapiens_hsa030200.73486233
40Osteoclast differentiation_Homo sapiens_hsa043800.70953375
41Protein export_Homo sapiens_hsa030600.68738477
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66746624
43Epstein-Barr virus infection_Homo sapiens_hsa051690.65293463
44Apoptosis_Homo sapiens_hsa042100.64988578
45HTLV-I infection_Homo sapiens_hsa051660.63935994
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62223130
47Alzheimers disease_Homo sapiens_hsa050100.61421900
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.59237128
49Influenza A_Homo sapiens_hsa051640.56840721
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54368427
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54268122
52Phototransduction_Homo sapiens_hsa047440.52872071
53Systemic lupus erythematosus_Homo sapiens_hsa053220.52807014
54Collecting duct acid secretion_Homo sapiens_hsa049660.48384762
55Linoleic acid metabolism_Homo sapiens_hsa005910.44062201
56Retinol metabolism_Homo sapiens_hsa008300.42171866
57African trypanosomiasis_Homo sapiens_hsa051430.40061095
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34040594
59Regulation of autophagy_Homo sapiens_hsa041400.32684979
60Huntingtons disease_Homo sapiens_hsa050160.31564065
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29806350
62Cardiac muscle contraction_Homo sapiens_hsa042600.29165484
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28312757
64Peroxisome_Homo sapiens_hsa041460.28076904
65Caffeine metabolism_Homo sapiens_hsa002320.27627094
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.26982409
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26887685
68Legionellosis_Homo sapiens_hsa051340.26242495
69Tuberculosis_Homo sapiens_hsa051520.23960124
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22441899
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22228409
72Endocytosis_Homo sapiens_hsa041440.22053783
73Lysosome_Homo sapiens_hsa041420.19496780
74Phagosome_Homo sapiens_hsa041450.19350988
75p53 signaling pathway_Homo sapiens_hsa041150.19246401
76Nitrogen metabolism_Homo sapiens_hsa009100.18759413
77One carbon pool by folate_Homo sapiens_hsa006700.18409680
78Pyrimidine metabolism_Homo sapiens_hsa002400.17870475
79Purine metabolism_Homo sapiens_hsa002300.17640229
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16914691
81Olfactory transduction_Homo sapiens_hsa047400.12656575
82Ribosome_Homo sapiens_hsa030100.11678104
83Homologous recombination_Homo sapiens_hsa034400.11615672
84Toxoplasmosis_Homo sapiens_hsa051450.10991708
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10073992
86Morphine addiction_Homo sapiens_hsa050320.09242355
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09066675
88Dorso-ventral axis formation_Homo sapiens_hsa043200.08319895
89N-Glycan biosynthesis_Homo sapiens_hsa005100.07959226
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.07327746
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.05143991
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.04477757
93Ras signaling pathway_Homo sapiens_hsa040140.03479604
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.03123394
95Fanconi anemia pathway_Homo sapiens_hsa034600.02616435
96RNA degradation_Homo sapiens_hsa030180.01632711
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.00800628
98Mismatch repair_Homo sapiens_hsa03430-0.0339815
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0155903
100Fc epsilon RI signaling pathway_Homo sapiens_hsa04664-0.0042449

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