TRAV29DV5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation by host of viral transcription (GO:0043922)7.80835503
2positive regulation of tolerance induction (GO:0002645)7.66530131
3regulation of T cell tolerance induction (GO:0002664)7.45188932
4regulation of lymphocyte chemotaxis (GO:1901623)7.25077463
5cytidine deamination (GO:0009972)7.07661546
6cytidine metabolic process (GO:0046087)7.07661546
7cytidine catabolic process (GO:0006216)7.07661546
8negative T cell selection (GO:0043383)6.88518181
9positive T cell selection (GO:0043368)6.54503796
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.38107059
11positive regulation of macrophage differentiation (GO:0045651)6.35650524
12pyrimidine ribonucleoside catabolic process (GO:0046133)6.28193166
13regulation of tolerance induction (GO:0002643)6.16720204
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.15505990
15DNA deamination (GO:0045006)6.06400938
16positive regulation of lymphocyte migration (GO:2000403)5.82024003
17negative thymic T cell selection (GO:0045060)5.49639463
18cellular response to interleukin-15 (GO:0071350)5.42868962
19regulation of B cell receptor signaling pathway (GO:0050855)5.34254403
20T cell selection (GO:0045058)5.26193176
21negative regulation of T cell receptor signaling pathway (GO:0050860)5.07078427
22thymic T cell selection (GO:0045061)5.06393768
23regulation of alpha-beta T cell proliferation (GO:0046640)5.00401404
24response to interleukin-15 (GO:0070672)4.99934535
25regulation of T cell receptor signaling pathway (GO:0050856)4.92740837
26modulation by host of viral transcription (GO:0043921)4.92003926
27modulation by host of symbiont transcription (GO:0052472)4.92003926
28regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.85580176
29positive thymic T cell selection (GO:0045059)4.84820601
30regulation of isotype switching to IgG isotypes (GO:0048302)4.75721390
31positive regulation of gamma-delta T cell activation (GO:0046645)4.72453406
32negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.69149349
33modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.62032498
34positive regulation of calcium-mediated signaling (GO:0050850)4.60882604
35negative regulation of cell killing (GO:0031342)4.59999872
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59999872
37tolerance induction (GO:0002507)4.57372803
38regulation of lymphocyte migration (GO:2000401)4.56292440
39mucosal-associated lymphoid tissue development (GO:0048537)4.54942512
40Peyers patch development (GO:0048541)4.54942512
41negative regulation of T cell mediated immunity (GO:0002710)4.47973005
42regulation of B cell differentiation (GO:0045577)4.41344444
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.36736892
44eosinophil chemotaxis (GO:0048245)4.20500412
45negative regulation of viral transcription (GO:0032897)4.14328265
46negative regulation of T cell differentiation in thymus (GO:0033085)4.11466148
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.08658515
48regulation of gamma-delta T cell differentiation (GO:0045586)4.08624197
49regulation of regulatory T cell differentiation (GO:0045589)4.02771343
50regulation of interleukin-2 biosynthetic process (GO:0045076)3.99256588
51T cell migration (GO:0072678)3.93973648
52lymphocyte chemotaxis (GO:0048247)3.92363424
53regulation of T cell chemotaxis (GO:0010819)3.91908477
54positive regulation of T cell chemotaxis (GO:0010820)3.91908477
55proteasome assembly (GO:0043248)3.89343881
56T cell receptor signaling pathway (GO:0050852)3.86656594
57positive regulation of T cell apoptotic process (GO:0070234)3.85503220
58macrophage chemotaxis (GO:0048246)3.82807984
59eosinophil migration (GO:0072677)3.77093174
60negative regulation of alpha-beta T cell activation (GO:0046636)3.73463423
61positive regulation of T cell mediated cytotoxicity (GO:0001916)3.68178534
62regulation of gamma-delta T cell activation (GO:0046643)3.61754588
63positive regulation of astrocyte differentiation (GO:0048711)3.59622310
64regulation of macrophage differentiation (GO:0045649)3.59443369
65positive regulation of interleukin-2 production (GO:0032743)3.54850874
66negative regulation of T cell apoptotic process (GO:0070233)3.43855130
67antigen receptor-mediated signaling pathway (GO:0050851)3.42226548
68negative regulation of B cell activation (GO:0050869)3.37348477
69positive regulation of lymphocyte apoptotic process (GO:0070230)3.36623590
70NIK/NF-kappaB signaling (GO:0038061)3.35257789
71natural killer cell differentiation (GO:0001779)3.31397637
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.31280304
73regulation of T cell mediated cytotoxicity (GO:0001914)3.28470484
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28204839
75regulation of calcium-mediated signaling (GO:0050848)3.27666261
76modification by host of symbiont morphology or physiology (GO:0051851)3.25394980
77cellular response to lithium ion (GO:0071285)3.22541675
78positive regulation of T cell migration (GO:2000406)3.22133716
79regulation of T cell cytokine production (GO:0002724)3.21780455
80regulation of T cell apoptotic process (GO:0070232)3.18354095
81necroptotic process (GO:0070266)3.17204486
82positive regulation of T cell mediated immunity (GO:0002711)3.13565438
83T cell costimulation (GO:0031295)3.11342116
84positive regulation of alpha-beta T cell proliferation (GO:0046641)3.10334713
85positive regulation of T cell cytokine production (GO:0002726)3.08960784
86dopamine biosynthetic process (GO:0042416)3.08141469
87response to insecticide (GO:0017085)3.08101563
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.08051369
89cellular defense response (GO:0006968)3.07662889
90lymphocyte costimulation (GO:0031294)3.07341378
91positive regulation of cell killing (GO:0031343)3.05812187
92positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.05632952
93signal peptide processing (GO:0006465)3.05121137
94regulation of interleukin-2 production (GO:0032663)3.04618870
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03277144
96regulation of chronic inflammatory response (GO:0002676)3.02885983
97positive regulation of interleukin-4 production (GO:0032753)3.01962469
98interaction with symbiont (GO:0051702)3.00413035
99regulation of leukocyte mediated cytotoxicity (GO:0001910)2.99986237
100myeloid dendritic cell differentiation (GO:0043011)2.98845258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.31355135
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.88610731
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44786231
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.26623967
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22367153
6RUNX_20019798_ChIP-Seq_JUKART_Human3.17000395
7MYB_26560356_Chip-Seq_TH2_Human3.01466113
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.86826898
9STAT4_19710469_ChIP-ChIP_TH1__Mouse2.86469627
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71494528
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65831694
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.41528081
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37462125
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35128654
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19964633
16BP1_19119308_ChIP-ChIP_Hs578T_Human12.9837722
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.98872014
18SCL_19346495_ChIP-Seq_HPC-7_Human1.97251111
19MAF_26560356_Chip-Seq_TH1_Human1.95207868
20MYB_26560356_Chip-Seq_TH1_Human1.88685744
21GATA3_27048872_Chip-Seq_THYMUS_Human1.86294427
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86155854
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85605849
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78317303
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73939432
26SPI1_23547873_ChIP-Seq_NB4_Human1.65913516
27RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.65284993
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63698655
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.59450922
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58151289
31UTX_26944678_Chip-Seq_JUKART_Human1.55858233
32MAF_26560356_Chip-Seq_TH2_Human1.55318254
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45442233
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43473936
35GATA3_26560356_Chip-Seq_TH2_Human1.42450471
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38520463
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37142833
38MYC_22102868_ChIP-Seq_BL_Human1.36617173
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.35791372
40FOXP3_21729870_ChIP-Seq_TREG_Human1.29186875
41VDR_24763502_ChIP-Seq_THP-1_Human1.25240378
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23518990
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19528159
44VDR_23849224_ChIP-Seq_CD4+_Human1.19201294
45VDR_24787735_ChIP-Seq_THP-1_Human1.14220652
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12566755
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11282952
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.09289907
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08914770
50PU_27001747_Chip-Seq_BMDM_Mouse1.07877862
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06731679
52TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06443665
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05865966
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05750047
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04106813
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03994733
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02881140
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.02798351
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.00661417
60GATA3_26560356_Chip-Seq_TH1_Human0.95695246
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95098641
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90450495
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89832947
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89040375
65PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88720665
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88568806
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87629052
68GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87491098
69NOTCH1_21737748_ChIP-Seq_TLL_Human0.86793777
70IRF1_19129219_ChIP-ChIP_H3396_Human0.82702908
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79036756
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78878961
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78646853
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76288670
75SMRT_27268052_Chip-Seq_Bcells_Human0.75016737
76KDM2B_26808549_Chip-Seq_DND41_Human0.74065118
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73735200
78VDR_21846776_ChIP-Seq_THP-1_Human0.70069926
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69270998
80TCF7_22412390_ChIP-Seq_EML_Mouse0.68876397
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67146656
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67111897
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.66902640
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.64836641
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.64771975
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.64355189
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.63865514
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.63864041
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63806970
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.62303344
91BCL6_27268052_Chip-Seq_Bcells_Human0.61076640
92TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.61029832
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60689079
94TFEB_21752829_ChIP-Seq_HELA_Human0.60430891
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.59075993
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.58742828
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.57916758
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.56900852
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.56591474
100SPI1_23127762_ChIP-Seq_K562_Human0.56498785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.72809862
2MP0009333_abnormal_splenocyte_physiolog4.47045217
3MP0006082_CNS_inflammation4.34004273
4MP0005671_abnormal_response_to4.15261726
5MP0001873_stomach_inflammation4.05592913
6MP0001790_abnormal_immune_system3.94610241
7MP0005387_immune_system_phenotype3.94610241
8MP0005000_abnormal_immune_tolerance3.14944731
9MP0001835_abnormal_antigen_presentation2.87852095
10MP0002148_abnormal_hypersensitivity_rea2.84930282
11MP0001800_abnormal_humoral_immune2.84713766
12MP0002277_abnormal_respiratory_mucosa2.78016733
13MP0003436_decreased_susceptibility_to2.69450563
14MP0002723_abnormal_immune_serum2.65420569
15MP0002420_abnormal_adaptive_immunity2.57807879
16MP0002405_respiratory_system_inflammati2.54702449
17MP0001819_abnormal_immune_cell2.53920704
18MP0000703_abnormal_thymus_morphology2.46427524
19MP0002398_abnormal_bone_marrow2.35097852
20MP0000716_abnormal_immune_system2.20786021
21MP0003866_abnormal_defecation2.20763151
22MP0010155_abnormal_intestine_physiology2.13179182
23MP0002452_abnormal_antigen_presenting2.07075156
24MP0000685_abnormal_immune_system2.05281824
25MP0009785_altered_susceptibility_to2.03173203
26MP0008007_abnormal_cellular_replicative2.01582345
27MP0005025_abnormal_response_to2.01408419
28MP0000569_abnormal_digit_pigmentation1.83499320
29MP0001984_abnormal_olfaction1.80458409
30MP0002722_abnormal_immune_system1.79727848
31MP0003300_gastrointestinal_ulcer1.76984885
32MP0000689_abnormal_spleen_morphology1.70564439
33MP0004381_abnormal_hair_follicle1.66100285
34MP0002429_abnormal_blood_cell1.63503513
35MP0005075_abnormal_melanosome_morpholog1.61969585
36MP0004947_skin_inflammation1.61225842
37MP0000465_gastrointestinal_hemorrhage1.60745221
38MP0002419_abnormal_innate_immunity1.59845009
39MP0001188_hyperpigmentation1.58612393
40MP0001502_abnormal_circadian_rhythm1.53968419
41MP0001845_abnormal_inflammatory_respons1.52722822
42MP0005310_abnormal_salivary_gland1.46721699
43MP0005464_abnormal_platelet_physiology1.45587160
44MP0003786_premature_aging1.38270452
45MP0001348_abnormal_lacrimal_gland1.34145322
46MP0008569_lethality_at_weaning1.32384973
47MP0002933_joint_inflammation1.26486163
48MP0001853_heart_inflammation1.21133072
49MP0002132_abnormal_respiratory_system1.15412766
50MP0002163_abnormal_gland_morphology1.12676190
51MP0002998_abnormal_bone_remodeling1.10531484
52MP0002138_abnormal_hepatobiliary_system1.07563901
53MP0001919_abnormal_reproductive_system1.04538732
54MP0003724_increased_susceptibility_to1.03107650
55MP0004043_abnormal_pH_regulation1.01808361
56MP0005408_hypopigmentation0.99147368
57MP0003448_altered_tumor_morphology0.98718057
58MP0002166_altered_tumor_susceptibility0.97385577
59MP0008469_abnormal_protein_level0.95189798
60MP0004742_abnormal_vestibular_system0.92925250
61MP0000920_abnormal_myelination0.85612303
62MP0000371_diluted_coat_color0.85593704
63MP0000604_amyloidosis0.85585281
64MP0005076_abnormal_cell_differentiation0.85038611
65MP0001881_abnormal_mammary_gland0.83851090
66MP0008873_increased_physiological_sensi0.82370889
67MP0009763_increased_sensitivity_to0.81353270
68MP0000490_abnormal_crypts_of0.80667040
69MP0003195_calcinosis0.80618531
70MP0001533_abnormal_skeleton_physiology0.78677080
71MP0002019_abnormal_tumor_incidence0.74765262
72MP0004142_abnormal_muscle_tone0.74396948
73MP0001851_eye_inflammation0.71986650
74MP0001905_abnormal_dopamine_level0.67906885
75MP0001765_abnormal_ion_homeostasis0.63959043
76MP0001663_abnormal_digestive_system0.60471945
77MP0002693_abnormal_pancreas_physiology0.58539673
78MP0003795_abnormal_bone_structure0.56900392
79MP0000609_abnormal_liver_physiology0.56659997
80MP0003186_abnormal_redox_activity0.56141194
81MP0005379_endocrine/exocrine_gland_phen0.56065568
82MP0000627_abnormal_mammary_gland0.53361548
83MP0000858_altered_metastatic_potential0.50492102
84MP0003183_abnormal_peptide_metabolism0.50337367
85MP0003567_abnormal_fetal_cardiomyocyte0.50143046
86MP0002006_tumorigenesis0.49717561
87MP0002970_abnormal_white_adipose0.49157383
88MP0005334_abnormal_fat_pad0.48625583
89MP0003045_fibrosis0.47361407
90MP0001191_abnormal_skin_condition0.47111657
91MP0003303_peritoneal_inflammation0.46846789
92MP0005389_reproductive_system_phenotype0.45964137
93MP0003959_abnormal_lean_body0.44000344
94MP0002396_abnormal_hematopoietic_system0.42874483
95MP0005410_abnormal_fertilization0.41925701
96MP0002928_abnormal_bile_duct0.41183779
97MP0010307_abnormal_tumor_latency0.40553529
98MP0009384_cardiac_valve_regurgitation0.40030624
99MP0000477_abnormal_intestine_morphology0.39323897
100MP0001186_pigmentation_phenotype0.39126299

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)7.45674485
2Abnormality of T cell number (HP:0011839)5.85222997
3T lymphocytopenia (HP:0005403)5.46746795
4Gastrointestinal infarctions (HP:0005244)5.33759023
5Abnormality of eosinophils (HP:0001879)5.08147466
6Eosinophilia (HP:0001880)5.05933315
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.54990757
8Stomatitis (HP:0010280)4.47148383
9Granulocytopenia (HP:0001913)4.45210479
10Elevated erythrocyte sedimentation rate (HP:0003565)4.28712366
11Alveolar cell carcinoma (HP:0006519)4.21246225
12Abnormality of T cells (HP:0002843)4.18512557
13Hemiplegia (HP:0002301)4.18116374
14IgM deficiency (HP:0002850)4.13043984
15Vasculitis (HP:0002633)4.10857227
16Increased IgM level (HP:0003496)4.07238162
17Leukocytosis (HP:0001974)3.97805390
18Neoplasm of the tracheobronchial system (HP:0100552)3.81598958
19Chest pain (HP:0100749)3.74651500
20Severe combined immunodeficiency (HP:0004430)3.73422100
21Chronic diarrhea (HP:0002028)3.70749344
22Ureteral obstruction (HP:0006000)3.62155422
23Pulmonary infiltrates (HP:0002113)3.58909120
24Ureteral stenosis (HP:0000071)3.57184678
25Conjugated hyperbilirubinemia (HP:0002908)3.51647751
26Obstructive lung disease (HP:0006536)3.51457274
27Chronic obstructive pulmonary disease (HP:0006510)3.51457274
28Abnormality of the prostate (HP:0008775)3.44425944
29IgG deficiency (HP:0004315)3.40536451
30Meningitis (HP:0001287)3.38593505
31Gangrene (HP:0100758)3.38325752
32Hemoptysis (HP:0002105)3.35752983
33Mediastinal lymphadenopathy (HP:0100721)3.35430421
34Encephalitis (HP:0002383)3.25115535
35Recurrent bronchitis (HP:0002837)3.23774832
36Myositis (HP:0100614)3.22891611
37Recurrent fungal infections (HP:0002841)3.19227621
38Abnormality of cells of the lymphoid lineage (HP:0012140)3.15743452
39Autoimmune thrombocytopenia (HP:0001973)3.08862817
40Diplopia (HP:0000651)3.06817486
41Abnormality of binocular vision (HP:0011514)3.06817486
42Orchitis (HP:0100796)3.02456804
43Lymphopenia (HP:0001888)2.99496612
44Abnormality of T cell physiology (HP:0011840)2.98351476
45Optic neuritis (HP:0100653)2.91831746
46Retrobulbar optic neuritis (HP:0100654)2.91831746
47Chronic mucocutaneous candidiasis (HP:0002728)2.91499139
48Recurrent cutaneous fungal infections (HP:0011370)2.91499139
49Combined immunodeficiency (HP:0005387)2.89774767
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.87500473
51Hypoproteinemia (HP:0003075)2.77685859
52Abnormality of alanine metabolism (HP:0010916)2.75511620
53Hyperalaninemia (HP:0003348)2.75511620
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75511620
55Joint swelling (HP:0001386)2.70965979
56Hypoplasia of the thymus (HP:0000778)2.70197462
57Hypochromic anemia (HP:0001931)2.70139212
58Thyroiditis (HP:0100646)2.68902791
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.68240478
60Pulmonary embolism (HP:0002204)2.66136003
61Amaurosis fugax (HP:0100576)2.65517054
62Abnormality of macrophages (HP:0004311)2.61161149
63Recurrent bacterial skin infections (HP:0005406)2.58330168
64Increased cerebral lipofuscin (HP:0011813)2.56867378
65Pustule (HP:0200039)2.53031767
66Anorexia (HP:0002039)2.49194204
67Abnormality of the pleura (HP:0002103)2.45790276
68Rhabdomyosarcoma (HP:0002859)2.38742183
69Recurrent skin infections (HP:0001581)2.38119361
70Renal cortical cysts (HP:0000803)2.37373168
71Lymphoma (HP:0002665)2.34951238
72Recurrent abscess formation (HP:0002722)2.30489604
73Premature loss of primary teeth (HP:0006323)2.23165439
74Agammaglobulinemia (HP:0004432)2.22825745
75Abnormality of the right ventricle (HP:0001707)2.22328135
76Glomerulopathy (HP:0100820)2.21323273
77Eczematoid dermatitis (HP:0000976)2.21262767
78Abnormality of the pericardium (HP:0001697)2.20642441
79Renal tubular acidosis (HP:0001947)2.16327618
80Bronchitis (HP:0012387)2.14008761
81Hypergammaglobulinemia (HP:0010702)2.13081113
82Spontaneous hematomas (HP:0007420)2.12875311
83Periodontitis (HP:0000704)2.09518265
84Abnormality of the radial head (HP:0003995)2.08674580
85Scanning speech (HP:0002168)2.04870547
86Increased CSF protein (HP:0002922)1.99439297
87Dislocated radial head (HP:0003083)1.98384851
88Keratoconjunctivitis sicca (HP:0001097)1.95572820
89Recurrent viral infections (HP:0004429)1.93362201
90Abnormality of the alveolar ridges (HP:0006477)1.91309120
91Malignant hyperthermia (HP:0002047)1.89779532
92Arterial thrombosis (HP:0004420)1.89356655
93Polyneuropathy (HP:0001271)1.86957024
94Skin rash (HP:0000988)1.83276832
95Abnormality of male internal genitalia (HP:0000022)1.81296678
96Congenital stationary night blindness (HP:0007642)1.80223570
97Keratoconjunctivitis (HP:0001096)1.80148796
98Epistaxis (HP:0000421)1.79797305
99Pulmonary fibrosis (HP:0002206)1.78671695
100Restrictive lung disease (HP:0002091)1.74374720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.29833122
2MAP4K15.53194233
3ITK4.28819092
4BUB14.23968408
5KDR3.96417400
6AKT33.39140765
7CSK2.76633988
8TNK22.73758533
9PRKCQ2.16948674
10SRPK11.93429349
11MAP3K111.86234171
12IKBKE1.84698816
13LCK1.83199995
14FGFR11.82480813
15TBK11.78456465
16JAK31.77054192
17MAP2K71.66423336
18BTK1.65702501
19IKBKB1.53523543
20TESK21.51924129
21MARK31.51095972
22FES1.50434084
23ZAP701.48190625
24MAP2K61.46299866
25IRAK41.46185806
26SYK1.32958115
27PRKCH1.25509476
28TEC1.25263049
29PAK21.17814982
30HCK1.10375707
31LYN1.07789873
32BCR1.01453654
33GRK61.00932898
34WNK40.94128964
35MAP3K130.93831291
36CAMKK20.89929984
37TYK20.89234125
38MAP3K10.89176747
39MAP3K140.86983682
40PASK0.84826003
41CSF1R0.82455459
42BRAF0.81161278
43ERBB30.76624965
44RIPK40.76504411
45MAPK120.72147764
46ERN10.71680788
47JAK10.69050886
48STK240.66682121
49RPS6KB10.66263781
50FYN0.64701581
51PRKD20.64002478
52IRAK10.62662712
53TAOK30.61932165
54PRKCZ0.57156261
55IRAK20.56348554
56CHUK0.56018307
57CAMKK10.54493682
58AURKA0.49476817
59JAK20.48164143
60BLK0.47626007
61INSR0.44698017
62NLK0.42952982
63WNK10.41278500
64MAP3K30.38988411
65IGF1R0.37194755
66RPS6KA10.36664503
67TAOK20.36504600
68PDK10.35989892
69MAP3K70.35727019
70KIT0.34376041
71SGK20.33010274
72PDGFRB0.31298470
73MAPK30.31211459
74SGK30.30726862
75TYRO30.30459312
76FGFR40.29738689
77MAP2K30.28747702
78PRKACG0.27269052
79CDK40.27208623
80MAPK70.27192857
81PLK20.26217664
82PRPF4B0.25264577
83PIM10.25252748
84MAPKAPK20.24836152
85MAPK90.24256755
86PRKCA0.24078442
87SIK30.23797378
88EPHB10.23015971
89CDK30.22682063
90CSNK1A10.22597732
91TAOK10.20932231
92PIK3CA0.19861903
93GRK70.17012059
94VRK10.15230233
95NUAK10.14819424
96CLK10.14536618
97PAK30.13890700
98SGK10.13701019
99PRKACA0.13329800
100PRKCD0.12852526

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.53505070
2T cell receptor signaling pathway_Homo sapiens_hsa046604.02185753
3Graft-versus-host disease_Homo sapiens_hsa053323.86838351
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.51490972
5Autoimmune thyroid disease_Homo sapiens_hsa053203.38185364
6Allograft rejection_Homo sapiens_hsa053303.10057721
7Toll-like receptor signaling pathway_Homo sapiens_hsa046203.00592533
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.99283767
9Antigen processing and presentation_Homo sapiens_hsa046122.93414030
10Measles_Homo sapiens_hsa051622.83726399
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.71982843
12Salmonella infection_Homo sapiens_hsa051322.54282188
13Type I diabetes mellitus_Homo sapiens_hsa049402.50463506
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29894709
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.24677944
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.21458097
17Hematopoietic cell lineage_Homo sapiens_hsa046402.14631655
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.13033184
19Osteoclast differentiation_Homo sapiens_hsa043801.92618443
20Rheumatoid arthritis_Homo sapiens_hsa053231.90992492
21Basal transcription factors_Homo sapiens_hsa030221.76212234
22Chemokine signaling pathway_Homo sapiens_hsa040621.68469449
23TNF signaling pathway_Homo sapiens_hsa046681.64316552
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45266816
25Pentose phosphate pathway_Homo sapiens_hsa000301.44920168
26African trypanosomiasis_Homo sapiens_hsa051431.33624656
27Herpes simplex infection_Homo sapiens_hsa051681.29789712
28Proteasome_Homo sapiens_hsa030501.22870078
29Leishmaniasis_Homo sapiens_hsa051401.21870742
30B cell receptor signaling pathway_Homo sapiens_hsa046621.14349481
31Protein export_Homo sapiens_hsa030601.09326022
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.09007989
33Apoptosis_Homo sapiens_hsa042101.02762619
34VEGF signaling pathway_Homo sapiens_hsa043700.98062141
35Nucleotide excision repair_Homo sapiens_hsa034200.92728484
36Malaria_Homo sapiens_hsa051440.90416895
37Staphylococcus aureus infection_Homo sapiens_hsa051500.89481084
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86114700
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85015301
40Shigellosis_Homo sapiens_hsa051310.84290942
41Hepatitis B_Homo sapiens_hsa051610.83541252
42Viral myocarditis_Homo sapiens_hsa054160.81047066
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78712238
44HTLV-I infection_Homo sapiens_hsa051660.76970629
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74229656
46Chronic myeloid leukemia_Homo sapiens_hsa052200.69384397
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66263105
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65477201
49Epstein-Barr virus infection_Homo sapiens_hsa051690.64968666
50MAPK signaling pathway_Homo sapiens_hsa040100.64071489
51Viral carcinogenesis_Homo sapiens_hsa052030.63147966
52Tuberculosis_Homo sapiens_hsa051520.62440752
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.61242035
54Toxoplasmosis_Homo sapiens_hsa051450.60917688
55Platelet activation_Homo sapiens_hsa046110.57626519
56Influenza A_Homo sapiens_hsa051640.56799640
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54007871
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50664864
59Hepatitis C_Homo sapiens_hsa051600.48049868
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46741196
61Asthma_Homo sapiens_hsa053100.46030923
62Non-small cell lung cancer_Homo sapiens_hsa052230.45135253
63Pertussis_Homo sapiens_hsa051330.44224197
64Legionellosis_Homo sapiens_hsa051340.43179542
65Endocytosis_Homo sapiens_hsa041440.42611437
66Acute myeloid leukemia_Homo sapiens_hsa052210.42597306
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41203804
68HIF-1 signaling pathway_Homo sapiens_hsa040660.40577938
69mRNA surveillance pathway_Homo sapiens_hsa030150.38814237
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38637874
71Renal cell carcinoma_Homo sapiens_hsa052110.37381307
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35995910
73Renin-angiotensin system_Homo sapiens_hsa046140.35962298
74Sulfur metabolism_Homo sapiens_hsa009200.35583452
75Colorectal cancer_Homo sapiens_hsa052100.32363585
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31986487
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.28149780
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25471326
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.24673824
80Notch signaling pathway_Homo sapiens_hsa043300.23514743
81Renin secretion_Homo sapiens_hsa049240.20485244
82Long-term potentiation_Homo sapiens_hsa047200.20285451
83Rap1 signaling pathway_Homo sapiens_hsa040150.19526224
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19222855
85Circadian rhythm_Homo sapiens_hsa047100.18769341
86ErbB signaling pathway_Homo sapiens_hsa040120.18252847
87Thyroid cancer_Homo sapiens_hsa052160.15236452
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14577568
89Insulin signaling pathway_Homo sapiens_hsa049100.13482261
90Lysosome_Homo sapiens_hsa041420.11644343
91Prion diseases_Homo sapiens_hsa050200.10086047
92Ras signaling pathway_Homo sapiens_hsa040140.09431240
93FoxO signaling pathway_Homo sapiens_hsa040680.09172150
94Prolactin signaling pathway_Homo sapiens_hsa049170.09049059
95Nitrogen metabolism_Homo sapiens_hsa009100.07589894
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07333247
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07229022
98Collecting duct acid secretion_Homo sapiens_hsa049660.06825110
99Vitamin B6 metabolism_Homo sapiens_hsa007500.06514428
100p53 signaling pathway_Homo sapiens_hsa041150.05862206

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