TRAV3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cytokine production involved in inflammatory response (GO:1900015)7.99227105
2positive regulation of gamma-delta T cell activation (GO:0046645)6.50441734
3regulation of regulatory T cell differentiation (GO:0045589)6.28935218
4NIK/NF-kappaB signaling (GO:0038061)6.06523369
5negative regulation of cell killing (GO:0031342)6.03534289
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.03534289
7negative T cell selection (GO:0043383)5.99982023
8negative thymic T cell selection (GO:0045060)5.96444648
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.90891813
10tolerance induction (GO:0002507)5.85329336
11response to interleukin-15 (GO:0070672)5.64206275
12myeloid dendritic cell differentiation (GO:0043011)5.63694862
13cellular response to interleukin-15 (GO:0071350)5.48859766
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.23151591
15positive thymic T cell selection (GO:0045059)5.22008345
16regulation of gamma-delta T cell differentiation (GO:0045586)5.13603680
17myeloid dendritic cell activation (GO:0001773)5.09687268
18regulation of interleukin-2 biosynthetic process (GO:0045076)5.06841575
19thymic T cell selection (GO:0045061)5.02878374
20leukocyte aggregation (GO:0070486)5.00418052
21DNA deamination (GO:0045006)4.87636521
22positive T cell selection (GO:0043368)4.86609419
23regulation of T cell tolerance induction (GO:0002664)4.86537482
24alpha-beta T cell differentiation (GO:0046632)4.78443030
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77491672
26positive regulation of tolerance induction (GO:0002645)4.68234044
27regulation of gamma-delta T cell activation (GO:0046643)4.65341094
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.57057470
29positive regulation of granulocyte differentiation (GO:0030854)4.56334641
30T cell selection (GO:0045058)4.52957992
31regulation of B cell receptor signaling pathway (GO:0050855)4.45646993
32regulation of T cell mediated cytotoxicity (GO:0001914)4.45017609
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.41844286
34negative regulation of T cell mediated immunity (GO:0002710)4.36619633
35cytidine deamination (GO:0009972)4.31604878
36cytidine metabolic process (GO:0046087)4.31604878
37cytidine catabolic process (GO:0006216)4.31604878
38regulation of interleukin-12 biosynthetic process (GO:0045075)4.28563308
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26031632
40lymph node development (GO:0048535)4.25766362
41positive regulation of alpha-beta T cell proliferation (GO:0046641)4.24557570
42regulation of isotype switching to IgG isotypes (GO:0048302)4.21463530
43T cell receptor signaling pathway (GO:0050852)4.21149317
44antigen processing and presentation of endogenous antigen (GO:0019883)4.18677934
45regulation of alpha-beta T cell proliferation (GO:0046640)4.17355664
46alpha-beta T cell activation (GO:0046631)4.11808315
47regulation of interleukin-6 biosynthetic process (GO:0045408)4.09703292
48regulation of tolerance induction (GO:0002643)4.07480103
49pyrimidine ribonucleoside catabolic process (GO:0046133)3.96349466
50T cell homeostasis (GO:0043029)3.96294729
51positive regulation of T cell cytokine production (GO:0002726)3.88236306
52cytokine biosynthetic process (GO:0042089)3.86245579
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.83875195
54antigen receptor-mediated signaling pathway (GO:0050851)3.81085659
55positive regulation of defense response to virus by host (GO:0002230)3.79295302
56positive regulation of T cell mediated cytotoxicity (GO:0001916)3.75252005
57T cell differentiation (GO:0030217)3.73697973
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.73548761
59positive regulation of interleukin-2 production (GO:0032743)3.68593615
60negative regulation of lymphocyte mediated immunity (GO:0002707)3.63840593
61regulation of T cell mediated immunity (GO:0002709)3.62908672
62interferon-gamma production (GO:0032609)3.60735515
63regulation of T cell cytokine production (GO:0002724)3.60027786
64regulation of cell killing (GO:0031341)3.59398794
65regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.58982259
66regulation of natural killer cell mediated immunity (GO:0002715)3.58982259
67activated T cell proliferation (GO:0050798)3.57492082
68regulation of immunoglobulin secretion (GO:0051023)3.56655310
69T-helper 1 type immune response (GO:0042088)3.56074426
70positive regulation of osteoclast differentiation (GO:0045672)3.55870862
71positive regulation of T cell mediated immunity (GO:0002711)3.53630227
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52774919
73positive regulation of T cell differentiation in thymus (GO:0033089)3.49148658
74positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.48165507
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.48111790
76positive regulation of transcription regulatory region DNA binding (GO:2000679)3.45588503
77T-helper cell differentiation (GO:0042093)3.44136680
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.44136680
79neutrophil activation involved in immune response (GO:0002283)3.43775268
80regulation of interleukin-2 production (GO:0032663)3.43041082
81antigen processing and presentation via MHC class Ib (GO:0002475)3.33815375
82dendritic cell differentiation (GO:0097028)3.32636563
83regulation of thymocyte apoptotic process (GO:0070243)3.32286864
84negative regulation of T cell apoptotic process (GO:0070233)3.31838976
85positive regulation of cell killing (GO:0031343)3.30227638
86regulation of alpha-beta T cell activation (GO:0046634)3.28362041
87negative regulation of leukocyte mediated immunity (GO:0002704)3.28323322
88positive regulation of humoral immune response (GO:0002922)3.26993901
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.26632284
90negative regulation of thymocyte apoptotic process (GO:0070244)3.24072865
91regulation of T cell apoptotic process (GO:0070232)3.23800069
92cytokine metabolic process (GO:0042107)3.23646185
93T cell differentiation involved in immune response (GO:0002292)3.23335498
94alpha-beta T cell differentiation involved in immune response (GO:0002293)3.23335498
95alpha-beta T cell activation involved in immune response (GO:0002287)3.23335498
96negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23014853
97negative regulation of interleukin-12 production (GO:0032695)3.22308025
98positive regulation of natural killer cell mediated immunity (GO:0002717)3.20234463
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.20202717
100negative regulation of T-helper cell differentiation (GO:0045623)3.20202717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.91159663
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.02975364
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.58555602
4RUNX_20019798_ChIP-Seq_JUKART_Human4.35183184
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.11849088
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.86211017
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84298944
8MYB_26560356_Chip-Seq_TH2_Human3.47304773
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.27533187
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.05285839
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.03565894
12FLI1_27457419_Chip-Seq_LIVER_Mouse3.02123527
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72199865
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.70350487
15MAF_26560356_Chip-Seq_TH1_Human2.56448654
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.50727820
17MYB_26560356_Chip-Seq_TH1_Human2.48672823
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.36838410
19GATA3_27048872_Chip-Seq_THYMUS_Human2.30583003
20UTX_26944678_Chip-Seq_JUKART_Human2.25984754
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.19338138
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16334154
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04083849
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00628645
25GATA3_26560356_Chip-Seq_TH2_Human1.99754710
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96813355
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94712154
28MAF_26560356_Chip-Seq_TH2_Human1.86762674
29SPI1_23547873_ChIP-Seq_NB4_Human1.77995289
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75336115
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73102347
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70655119
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67877888
34RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.67498151
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.63176974
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.57503791
37VDR_23849224_ChIP-Seq_CD4+_Human1.49938054
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48460752
39MYC_22102868_ChIP-Seq_BL_Human1.47436274
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45979515
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43257462
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42261750
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38930953
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37851771
45SPI1_23127762_ChIP-Seq_K562_Human1.36313164
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35666120
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33970573
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32074706
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30897717
50SCL_19346495_ChIP-Seq_HPC-7_Human1.29338001
51FOXP3_21729870_ChIP-Seq_TREG_Human1.21100637
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20565760
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.19411584
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15796843
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13195756
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10442916
57CIITA_25753668_ChIP-Seq_RAJI_Human1.10065899
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09972185
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.09758711
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08108447
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.06122511
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.05429189
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03887720
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03658880
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02060947
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01409756
67VDR_24763502_ChIP-Seq_THP-1_Human1.01162742
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00550949
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99149374
70IGF1R_20145208_ChIP-Seq_DFB_Human0.97230259
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96803476
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96229998
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95617376
74PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94492447
75BCL6_27268052_Chip-Seq_Bcells_Human0.94384673
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92511598
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91881735
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88652029
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88080425
80CRX_20693478_ChIP-Seq_RETINA_Mouse0.87798978
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87708623
82PU_27001747_Chip-Seq_BMDM_Mouse0.83822890
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83523659
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83132470
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82389964
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81838457
87CTCF_26484167_Chip-Seq_Bcells_Mouse0.81757346
88SMAD1_18555785_Chip-Seq_ESCs_Mouse0.81677510
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80074916
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79244866
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78659606
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78236045
93RUNX1_27457419_Chip-Seq_LIVER_Mouse0.78168978
94CTCF_18555785_Chip-Seq_ESCs_Mouse0.78072724
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77840411
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77756049
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77210908
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77011046
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.76127478
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.76058799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.19629170
2MP0003763_abnormal_thymus_physiology4.52742820
3MP0003436_decreased_susceptibility_to4.30090416
4MP0001790_abnormal_immune_system4.16486997
5MP0005387_immune_system_phenotype4.16486997
6MP0009785_altered_susceptibility_to3.69516050
7MP0002933_joint_inflammation3.48311642
8MP0005000_abnormal_immune_tolerance3.32428862
9MP0001835_abnormal_antigen_presentation3.28148616
10MP0001800_abnormal_humoral_immune3.27654086
11MP0010155_abnormal_intestine_physiology3.03933075
12MP0003724_increased_susceptibility_to3.02742330
13MP0005025_abnormal_response_to2.77893164
14MP0002723_abnormal_immune_serum2.77653317
15MP0002420_abnormal_adaptive_immunity2.71033254
16MP0001819_abnormal_immune_cell2.67830442
17MP0003866_abnormal_defecation2.66892275
18MP0001873_stomach_inflammation2.54265101
19MP0002452_abnormal_antigen_presenting2.49267403
20MP0000685_abnormal_immune_system2.48079208
21MP0002148_abnormal_hypersensitivity_rea2.43066309
22MP0006082_CNS_inflammation2.42692319
23MP0002405_respiratory_system_inflammati2.42617151
24MP0009333_abnormal_splenocyte_physiolog2.19820845
25MP0000703_abnormal_thymus_morphology2.19168625
26MP0002398_abnormal_bone_marrow2.10963667
27MP0000716_abnormal_immune_system2.10051697
28MP0001533_abnormal_skeleton_physiology2.08082900
29MP0002419_abnormal_innate_immunity1.97434925
30MP0002277_abnormal_respiratory_mucosa1.97044735
31MP0002722_abnormal_immune_system1.87738131
32MP0001849_ear_inflammation1.79983156
33MP0005310_abnormal_salivary_gland1.74434558
34MP0000689_abnormal_spleen_morphology1.73253441
35MP0002166_altered_tumor_susceptibility1.69090292
36MP0001845_abnormal_inflammatory_respons1.65946805
37MP0002429_abnormal_blood_cell1.60755723
38MP0008875_abnormal_xenobiotic_pharmacok1.57396320
39MP0004947_skin_inflammation1.48067730
40MP0000490_abnormal_crypts_of1.45943460
41MP0008469_abnormal_protein_level1.41500353
42MP0002396_abnormal_hematopoietic_system1.39590156
43MP0001853_heart_inflammation1.30539625
44MP0003300_gastrointestinal_ulcer1.24696033
45MP0000465_gastrointestinal_hemorrhage1.18966338
46MP0004381_abnormal_hair_follicle1.12793916
47MP0005075_abnormal_melanosome_morpholog1.07814166
48MP0002006_tumorigenesis1.04949054
49MP0003303_peritoneal_inflammation1.03423974
50MP0005464_abnormal_platelet_physiology1.01782416
51MP0008873_increased_physiological_sensi0.99803309
52MP0001851_eye_inflammation0.99267835
53MP0009764_decreased_sensitivity_to0.98052682
54MP0003448_altered_tumor_morphology0.93658157
55MP0002095_abnormal_skin_pigmentation0.92299041
56MP0002163_abnormal_gland_morphology0.91473270
57MP0001764_abnormal_homeostasis0.89055774
58MP0005390_skeleton_phenotype0.87678718
59MP0000372_irregular_coat_pigmentation0.86223848
60MP0002998_abnormal_bone_remodeling0.84944895
61MP0008569_lethality_at_weaning0.83508330
62MP0001663_abnormal_digestive_system0.79998115
63MP0001765_abnormal_ion_homeostasis0.77873455
64MP0002693_abnormal_pancreas_physiology0.74719294
65MP0009763_increased_sensitivity_to0.74343474
66MP0003252_abnormal_bile_duct0.74260680
67MP0002653_abnormal_ependyma_morphology0.71325347
68MP0005187_abnormal_penis_morphology0.70727333
69MP0001986_abnormal_taste_sensitivity0.70711269
70MP0004510_myositis0.70248914
71MP0001919_abnormal_reproductive_system0.69784811
72MP0002138_abnormal_hepatobiliary_system0.68408656
73MP0008260_abnormal_autophagy0.68225055
74MP0001243_abnormal_dermal_layer0.66132016
75MP0002132_abnormal_respiratory_system0.64633980
76MP0005584_abnormal_enzyme/coenzyme_acti0.63343296
77MP0005319_abnormal_enzyme/_coenzyme0.62793067
78MP0003878_abnormal_ear_physiology0.62311174
79MP0005377_hearing/vestibular/ear_phenot0.62311174
80MP0000858_altered_metastatic_potential0.59124967
81MP0002019_abnormal_tumor_incidence0.58614399
82MP0002254_reproductive_system_inflammat0.57055212
83MP0008872_abnormal_physiological_respon0.55299250
84MP0003828_pulmonary_edema0.54190619
85MP0001348_abnormal_lacrimal_gland0.53047627
86MP0003045_fibrosis0.53023340
87MP0001501_abnormal_sleep_pattern0.49008131
88MP0005166_decreased_susceptibility_to0.48580268
89MP0000604_amyloidosis0.46774350
90MP0001661_extended_life_span0.46475167
91MP0008874_decreased_physiological_sensi0.46441652
92MP0000920_abnormal_myelination0.46422060
93MP0005636_abnormal_mineral_homeostasis0.45724669
94MP0003795_abnormal_bone_structure0.44899280
95MP0005379_endocrine/exocrine_gland_phen0.44114116
96MP0009765_abnormal_xenobiotic_induced0.43238036
97MP0005083_abnormal_biliary_tract0.42889547
98MP0003690_abnormal_glial_cell0.41154771
99MP0004808_abnormal_hematopoietic_stem0.40849684
100MP0005381_digestive/alimentary_phenotyp0.40631099

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.75545019
2Recurrent cutaneous fungal infections (HP:0011370)5.36643471
3Chronic mucocutaneous candidiasis (HP:0002728)5.36643471
4Abnormality of T cell number (HP:0011839)5.32674507
5Autoimmune hemolytic anemia (HP:0001890)5.23119524
6Abnormality of T cells (HP:0002843)5.16116232
7Elevated erythrocyte sedimentation rate (HP:0003565)4.97945323
8Severe combined immunodeficiency (HP:0004430)4.71415376
9Stomatitis (HP:0010280)4.69183776
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.61628032
11IgG deficiency (HP:0004315)4.53485162
12IgM deficiency (HP:0002850)4.43628934
13Abnormality of T cell physiology (HP:0011840)4.34773071
14Myositis (HP:0100614)4.32135930
15Panhypogammaglobulinemia (HP:0003139)4.06286685
16Encephalitis (HP:0002383)4.03331167
17Recurrent fungal infections (HP:0002841)4.02153290
18Combined immunodeficiency (HP:0005387)3.97951242
19Keratoconjunctivitis sicca (HP:0001097)3.85753003
20Retrobulbar optic neuritis (HP:0100654)3.84291572
21Optic neuritis (HP:0100653)3.84291572
22Lymphopenia (HP:0001888)3.82868287
23Increased hepatocellular lipid droplets (HP:0006565)3.82007303
24Eczematoid dermatitis (HP:0000976)3.81591811
25Periodontitis (HP:0000704)3.78027404
26Keratoconjunctivitis (HP:0001096)3.72433492
27Orchitis (HP:0100796)3.69925957
28Increased IgM level (HP:0003496)3.60216294
29Abnormality of cells of the lymphoid lineage (HP:0012140)3.51179084
30Lipid accumulation in hepatocytes (HP:0006561)3.39503448
31Hemoptysis (HP:0002105)3.36444269
32Vasculitis (HP:0002633)3.19347139
33Recurrent bronchitis (HP:0002837)3.17233258
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.15412931
35Meningitis (HP:0001287)3.09567212
36Renal Fanconi syndrome (HP:0001994)3.04767517
37Abnormality of eosinophils (HP:0001879)3.03984864
38Hypoproteinemia (HP:0003075)3.02503663
39Obstructive lung disease (HP:0006536)3.00239927
40Chronic obstructive pulmonary disease (HP:0006510)3.00239927
41Recurrent skin infections (HP:0001581)2.97517540
42Chronic diarrhea (HP:0002028)2.92974163
43Autoimmune thrombocytopenia (HP:0001973)2.90421327
44Pulmonary infiltrates (HP:0002113)2.89892836
45Increased intramyocellular lipid droplets (HP:0012240)2.83110636
46B lymphocytopenia (HP:0010976)2.82699421
47Joint swelling (HP:0001386)2.81429046
48Abnormality of B cell number (HP:0010975)2.77611391
49Exertional dyspnea (HP:0002875)2.75460072
50Premature loss of primary teeth (HP:0006323)2.73555535
51Abnormality of the pons (HP:0007361)2.72960176
52Hypoplasia of the pons (HP:0012110)2.66183379
53Leukocytosis (HP:0001974)2.65965108
54Thyroiditis (HP:0100646)2.64861369
55Long clavicles (HP:0000890)2.61025752
56Cheilitis (HP:0100825)2.59128083
57Abnormality of macrophages (HP:0004311)2.58552391
58Toxemia of pregnancy (HP:0100603)2.54169064
59Respiratory difficulties (HP:0002880)2.50529469
60Recurrent viral infections (HP:0004429)2.48736256
61Granulocytopenia (HP:0001913)2.46154271
62IgA deficiency (HP:0002720)2.45019749
63Increased muscle lipid content (HP:0009058)2.44156283
64Eosinophilia (HP:0001880)2.39974382
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37642592
66Lymphoma (HP:0002665)2.33850163
67Chest pain (HP:0100749)2.32356515
68Gastrointestinal infarctions (HP:0005244)2.30032667
69Gangrene (HP:0100758)2.27670791
70Pustule (HP:0200039)2.26322612
71Recurrent otitis media (HP:0000403)2.24151067
72Recurrent bacterial skin infections (HP:0005406)2.22330666
73Abnormality of the pleura (HP:0002103)2.19883963
74Recurrent abscess formation (HP:0002722)2.18971231
75Hyperlipoproteinemia (HP:0010980)2.14037015
76Hypergammaglobulinemia (HP:0010702)2.13531548
77Aplastic anemia (HP:0001915)2.10848159
78Abnormality of the prostate (HP:0008775)2.08063433
79Recurrent sinusitis (HP:0011108)2.04840570
80Mediastinal lymphadenopathy (HP:0100721)2.04228447
81Hypochromic anemia (HP:0001931)2.03579920
82Neutropenia (HP:0001875)2.03119229
83Pulmonary embolism (HP:0002204)2.03037287
84Increased IgE level (HP:0003212)2.02421014
85Malignant hyperthermia (HP:0002047)2.01109734
86Recurrent gram-negative bacterial infections (HP:0005420)2.00264456
87Generalized aminoaciduria (HP:0002909)1.99504937
88Inflammation of the large intestine (HP:0002037)1.96346218
89Anorexia (HP:0002039)1.95535014
90Joint hemorrhage (HP:0005261)1.94831404
91Spontaneous hematomas (HP:0007420)1.94212886
92Hypoplasia of the thymus (HP:0000778)1.93527731
93Skin rash (HP:0000988)1.91207333
94Petechiae (HP:0000967)1.90481059
95Hepatosplenomegaly (HP:0001433)1.90006097
96Amyotrophic lateral sclerosis (HP:0007354)1.89349918
97Polyneuropathy (HP:0001271)1.84938646
98Abnormality of renal resorption (HP:0011038)1.84481471
99Agammaglobulinemia (HP:0004432)1.82326097
100Gastrointestinal inflammation (HP:0004386)1.79113528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.15650947
2MAP4K14.13668713
3KDR4.01788515
4TESK23.41375220
5TNK22.70732031
6ZAP702.52048349
7NEK12.49582335
8RIPK42.44348770
9ITK2.19577115
10TYK22.11387221
11FES2.07193870
12CLK12.02740363
13MAP3K111.99745728
14LCK1.92288966
15JAK31.79955356
16CSF1R1.71945024
17BTK1.71331017
18SYK1.71158014
19GRK61.71066560
20MARK31.69240405
21BLK1.68943622
22CSK1.68207341
23ACVR1B1.62921979
24VRK21.55806109
25JAK11.55473089
26MAP3K141.50077731
27TAOK31.49005079
28HCK1.38055269
29MAP2K61.24919718
30IKBKE1.21453475
31TESK11.18503400
32MAP4K21.17572098
33LYN1.15502052
34SMG11.14718567
35PRKCQ1.11462912
36TEC1.07486577
37MAP3K31.02820520
38NUAK11.02368381
39MAP3K131.00275991
40ARAF0.94703232
41MAP2K30.91405748
42PIM10.90405251
43DAPK10.90123074
44VRK10.89064290
45MAP3K120.88608811
46CAMKK20.86021173
47PASK0.82037594
48PRKCH0.79588812
49EPHB10.79374574
50TAF10.79115312
51JAK20.77918284
52SIK30.77107087
53BRSK20.74096992
54HIPK20.70610114
55PDK10.69814807
56NLK0.68018920
57IKBKB0.67106051
58ERN10.66101131
59MELK0.64351806
60TLK10.63353592
61GRK50.61935898
62WNK40.59193690
63MST40.55868269
64STK100.54856744
65CAMKK10.53629199
66IRAK40.52351315
67TBK10.51839614
68LRRK20.50397998
69FYN0.48168676
70RPS6KA60.45820794
71RPS6KL10.43369121
72RPS6KC10.43369121
73TRPM70.42358480
74PRPF4B0.39910411
75CDK40.39588491
76KIT0.37783393
77MAPK110.37363713
78STK160.36785635
79MAPKAPK20.34619890
80FGR0.34146882
81PIM20.32559541
82IGF1R0.31048605
83LIMK10.29122337
84ADRBK20.29067694
85TAOK20.28504977
86RPS6KB10.27251578
87DAPK20.27168104
88SIK10.25452151
89MAPKAPK30.25348089
90STK380.24892332
91MAP3K50.23153175
92MAPK120.22035089
93FGFR40.21632906
94YES10.21546973
95PRKD20.20540433
96MAPK70.19794300
97PDPK10.19654463
98CDK70.18408844
99STK40.18326122
100INSR0.18143223

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.40700601
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.41111717
3Caffeine metabolism_Homo sapiens_hsa002324.35502217
4Autoimmune thyroid disease_Homo sapiens_hsa053203.25078347
5T cell receptor signaling pathway_Homo sapiens_hsa046603.13860830
6Graft-versus-host disease_Homo sapiens_hsa053322.84520440
7Measles_Homo sapiens_hsa051622.82916548
8Proteasome_Homo sapiens_hsa030502.80731856
9Allograft rejection_Homo sapiens_hsa053302.80376497
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.50476252
11Hematopoietic cell lineage_Homo sapiens_hsa046402.26366828
12Antigen processing and presentation_Homo sapiens_hsa046122.14719839
13Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.97822401
14Type I diabetes mellitus_Homo sapiens_hsa049401.95064390
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.89670886
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87406628
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.87222110
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67907628
19Osteoclast differentiation_Homo sapiens_hsa043801.65618767
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.57468957
21Leishmaniasis_Homo sapiens_hsa051401.44178922
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.41025966
23Shigellosis_Homo sapiens_hsa051311.39862635
24Viral myocarditis_Homo sapiens_hsa054161.31589587
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30436371
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22258599
27Rheumatoid arthritis_Homo sapiens_hsa053231.16330416
28Herpes simplex infection_Homo sapiens_hsa051681.14576953
29Chemokine signaling pathway_Homo sapiens_hsa040621.13048157
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07302234
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06852489
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03668609
33Phototransduction_Homo sapiens_hsa047441.02058381
34B cell receptor signaling pathway_Homo sapiens_hsa046620.99264365
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98244953
36Malaria_Homo sapiens_hsa051440.94475352
37Oxidative phosphorylation_Homo sapiens_hsa001900.87495726
38Ribosome_Homo sapiens_hsa030100.84407132
39Regulation of autophagy_Homo sapiens_hsa041400.84222263
40Staphylococcus aureus infection_Homo sapiens_hsa051500.82006534
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81827201
42Toxoplasmosis_Homo sapiens_hsa051450.81069438
43Pertussis_Homo sapiens_hsa051330.79508749
44Parkinsons disease_Homo sapiens_hsa050120.78390786
45TNF signaling pathway_Homo sapiens_hsa046680.77939208
46Epstein-Barr virus infection_Homo sapiens_hsa051690.77914207
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72256666
48Apoptosis_Homo sapiens_hsa042100.70334182
49African trypanosomiasis_Homo sapiens_hsa051430.67498465
50Tuberculosis_Homo sapiens_hsa051520.67368197
51Acute myeloid leukemia_Homo sapiens_hsa052210.67250168
52Hepatitis C_Homo sapiens_hsa051600.66968381
53Influenza A_Homo sapiens_hsa051640.65480852
54HTLV-I infection_Homo sapiens_hsa051660.64170087
55Asthma_Homo sapiens_hsa053100.63672134
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56228622
57Hepatitis B_Homo sapiens_hsa051610.54415968
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.52485318
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46952130
60Legionellosis_Homo sapiens_hsa051340.46621270
61Homologous recombination_Homo sapiens_hsa034400.45063114
62Endocytosis_Homo sapiens_hsa041440.44590275
63Platelet activation_Homo sapiens_hsa046110.41329545
64FoxO signaling pathway_Homo sapiens_hsa040680.39888398
65Huntingtons disease_Homo sapiens_hsa050160.39104268
66Viral carcinogenesis_Homo sapiens_hsa052030.38894310
67Non-small cell lung cancer_Homo sapiens_hsa052230.37724799
68Alzheimers disease_Homo sapiens_hsa050100.35528096
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.35438810
70Inositol phosphate metabolism_Homo sapiens_hsa005620.32059127
71RNA degradation_Homo sapiens_hsa030180.31099084
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29568304
73Morphine addiction_Homo sapiens_hsa050320.28521987
74Pancreatic cancer_Homo sapiens_hsa052120.28419427
75Salmonella infection_Homo sapiens_hsa051320.28222535
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27834825
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27246075
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.27217270
79Insulin resistance_Homo sapiens_hsa049310.24463218
80Mismatch repair_Homo sapiens_hsa034300.24182646
81Spliceosome_Homo sapiens_hsa030400.20134328
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20129755
83MAPK signaling pathway_Homo sapiens_hsa040100.20052413
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19380032
85Colorectal cancer_Homo sapiens_hsa052100.19257108
86Fanconi anemia pathway_Homo sapiens_hsa034600.19053934
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.18920625
88Chemical carcinogenesis_Homo sapiens_hsa052040.18828470
89VEGF signaling pathway_Homo sapiens_hsa043700.18168242
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18164335
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16744572
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15677631
93Dorso-ventral axis formation_Homo sapiens_hsa043200.15540694
94Glycerolipid metabolism_Homo sapiens_hsa005610.15471248
95Olfactory transduction_Homo sapiens_hsa047400.14636408
96DNA replication_Homo sapiens_hsa030300.12940606
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12307663
98Phagosome_Homo sapiens_hsa041450.10449588
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10344099
100Ras signaling pathway_Homo sapiens_hsa040140.08986430

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