TRAV36DV7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)9.64936478
2positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003609.40055643
3negative regulation of cardiac muscle hypertrophy (GO:0010614)8.51022089
4regulation of interleukin-12 biosynthetic process (GO:0045075)8.48498194
5negative regulation of glycogen biosynthetic process (GO:0045719)8.40871294
6galactose catabolic process (GO:0019388)8.27680207
7N-terminal protein amino acid acetylation (GO:0006474)8.27482290
8regulation of oxidative stress-induced neuron death (GO:1903203)8.22859315
9interleukin-6-mediated signaling pathway (GO:0070102)8.13481475
10negative regulation of muscle hypertrophy (GO:0014741)7.69482011
11regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00437.64690408
12regulation of energy homeostasis (GO:2000505)7.31098139
13membrane tubulation (GO:0097320)6.81643364
14protein localization to endosome (GO:0036010)6.72814131
15negative regulation of glycogen metabolic process (GO:0070874)6.72384983
16cellular response to interleukin-6 (GO:0071354)6.53293795
17regulation of cellular respiration (GO:0043457)5.77051344
18ribosomal small subunit biogenesis (GO:0042274)5.68197887
19viral transcription (GO:0019083)5.45842080
20response to interleukin-6 (GO:0070741)5.30923488
21regulation of vitamin D biosynthetic process (GO:0060556)5.22714254
22cysteine metabolic process (GO:0006534)5.20064494
23translational termination (GO:0006415)5.11749601
24positive regulation of gamma-delta T cell activation (GO:0046645)4.94538610
25galactose metabolic process (GO:0006012)4.63394658
26negative thymic T cell selection (GO:0045060)4.49761371
27forebrain morphogenesis (GO:0048853)4.40573142
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.39723531
29viral life cycle (GO:0019058)4.36885155
30negative T cell selection (GO:0043383)4.34247436
31N-terminal protein amino acid modification (GO:0031365)4.30984957
32protein heterotetramerization (GO:0051290)4.29377562
33sequestering of actin monomers (GO:0042989)4.26525232
34regulation of gamma-delta T cell differentiation (GO:0045586)4.25779608
35regulation of vitamin metabolic process (GO:0030656)4.21949922
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.16413562
37lymph node development (GO:0048535)4.14855340
38ribonucleoprotein complex biogenesis (GO:0022613)4.09399565
39megakaryocyte development (GO:0035855)4.08328423
40cotranslational protein targeting to membrane (GO:0006613)4.07308726
41response to nitrosative stress (GO:0051409)4.06387517
42ubiquinone biosynthetic process (GO:0006744)4.05057004
43protein targeting to ER (GO:0045047)4.02141769
44translational elongation (GO:0006414)3.99574225
45positive regulation of T cell apoptotic process (GO:0070234)3.93571074
46regulation of hypersensitivity (GO:0002883)3.91325323
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.82111149
48cellular protein complex disassembly (GO:0043624)3.78130513
49ribosome biogenesis (GO:0042254)3.78094387
50protein localization to endoplasmic reticulum (GO:0070972)3.71467269
51ribosomal large subunit biogenesis (GO:0042273)3.69943894
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.64230228
53negative regulation of T cell mediated immunity (GO:0002710)3.61663221
54negative regulation of potassium ion transport (GO:0043267)3.61326258
55regulation of gamma-delta T cell activation (GO:0046643)3.60823319
56ubiquinone metabolic process (GO:0006743)3.57336291
57regulation of the force of heart contraction (GO:0002026)3.56517996
58superoxide anion generation (GO:0042554)3.53085568
59positive regulation of natural killer cell differentiation (GO:0032825)3.52817504
60regulation of mitochondrial fission (GO:0090140)3.49949707
61regulation of chromatin binding (GO:0035561)3.49727625
62negative regulation of monooxygenase activity (GO:0032769)3.43872009
63ribosomal small subunit assembly (GO:0000028)3.43414483
64positive regulation of positive chemotaxis (GO:0050927)3.42966965
65positive regulation of interleukin-12 production (GO:0032735)3.42464690
66spermatid nucleus differentiation (GO:0007289)3.42355423
67quinone biosynthetic process (GO:1901663)3.41707276
68mucosal-associated lymphoid tissue development (GO:0048537)3.35263920
69Peyers patch development (GO:0048541)3.35263920
70chemokine-mediated signaling pathway (GO:0070098)3.34902203
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.34001923
72L-phenylalanine catabolic process (GO:0006559)3.34001923
73cytokine secretion (GO:0050663)3.29962024
74regulation of positive chemotaxis (GO:0050926)3.29706658
75mast cell activation (GO:0045576)3.28368089
76tyrosine metabolic process (GO:0006570)3.26797518
77valine metabolic process (GO:0006573)3.21490179
78mRNA modification (GO:0016556)3.18887208
79regulation of cardiac muscle hypertrophy (GO:0010611)3.18543612
80regulation of interleukin-2 biosynthetic process (GO:0045076)3.16590231
81protein complex disassembly (GO:0043241)3.12105008
82thymic T cell selection (GO:0045061)3.11513088
83regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.08073178
84positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.08073178
85regulation of muscle hypertrophy (GO:0014743)3.08065008
86negative regulation of cell killing (GO:0031342)3.07892968
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07892968
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03974360
89gamma-aminobutyric acid signaling pathway (GO:0007214)3.03459381
90negative regulation of T cell differentiation in thymus (GO:0033085)3.02984971
91erythrocyte maturation (GO:0043249)3.02916045
92regulation of mitochondrial depolarization (GO:0051900)3.01182061
93regulation of respiratory gaseous exchange (GO:0043576)3.00076388
94endoderm formation (GO:0001706)3.00047189
95negative regulation of erythrocyte differentiation (GO:0045647)2.97822055
96interkinetic nuclear migration (GO:0022027)2.95907503
97regulation of interleukin-12 production (GO:0032655)2.91204388
98positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.88986290
99regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.88986290
100respiratory chain complex IV assembly (GO:0008535)2.88438858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.73534278
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.99212351
3SRY_22984422_ChIP-ChIP_TESTIS_Rat3.81391328
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49644270
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.25843811
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09819812
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93663999
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93663999
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93663999
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76489275
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73966153
12DROSHA_22980978_ChIP-Seq_HELA_Human2.71819058
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69271510
14SCL_19346495_ChIP-Seq_HPC-7_Human2.61588604
15RUNX_20019798_ChIP-Seq_JUKART_Human2.58885092
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14453238
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.13222414
18GATA3_27048872_Chip-Seq_THYMUS_Human2.03782573
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97641797
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.91096651
21SPI1_23127762_ChIP-Seq_K562_Human1.87820560
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.87398964
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86138544
24GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.85490184
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81911889
26PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.73819109
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71200697
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64411884
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64369475
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.64319187
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64202730
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63995642
33EGR1_19032775_ChIP-ChIP_M12_Human1.60476229
34ZNF274_21170338_ChIP-Seq_K562_Hela1.54868478
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.53152266
36UTX_26944678_Chip-Seq_JUKART_Human1.51567471
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43789105
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.42192926
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41766680
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39031391
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37659297
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37133522
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.33512863
44MAF_26560356_Chip-Seq_TH2_Human1.28935389
45SPI1_23547873_ChIP-Seq_NB4_Human1.26079257
46CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25527888
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24047595
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23818955
49RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22023352
50RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18523728
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16077915
52MYB_26560356_Chip-Seq_TH2_Human1.15544438
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15076877
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14785663
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14036541
56MAF_26560356_Chip-Seq_TH1_Human1.13668459
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11351243
58GATA3_26560356_Chip-Seq_TH2_Human1.11084701
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10607104
60MYB_26560356_Chip-Seq_TH1_Human1.07226880
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.05667170
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05288631
63ER_23166858_ChIP-Seq_MCF-7_Human1.04692613
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04127643
65EZH2_22144423_ChIP-Seq_EOC_Human1.02768585
66GBX2_23144817_ChIP-Seq_PC3_Human1.01389158
67SA1_27219007_Chip-Seq_Bcells_Human1.00935497
68VDR_24763502_ChIP-Seq_THP-1_Human0.98424802
69ELK1_22589737_ChIP-Seq_MCF10A_Human0.97794465
70HTT_18923047_ChIP-ChIP_STHdh_Human0.97768458
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97668035
72VDR_21846776_ChIP-Seq_THP-1_Human0.95830366
73TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95314926
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94979026
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94676191
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94549991
77P300_27268052_Chip-Seq_Bcells_Human0.93400172
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93378566
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92123316
80IRF8_27001747_Chip-Seq_BMDM_Mouse0.91433482
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91248436
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89911339
83TP53_22127205_ChIP-Seq_IMR90_Human0.89128897
84RAC3_21632823_ChIP-Seq_H3396_Human0.87558014
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86940411
86PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86683535
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85127318
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84880626
89EZH2_27304074_Chip-Seq_ESCs_Mouse0.83389564
90EZH2_27294783_Chip-Seq_ESCs_Mouse0.80242876
91CEBPB_22108803_ChIP-Seq_LS180_Human0.78872101
92MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78061126
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76865206
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76534346
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76190960
96GF1_26923725_Chip-Seq_HPCs_Mouse0.75827765
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.75531424
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74978591
99NANOG_20526341_ChIP-Seq_ESCs_Human0.74907128
100SUZ12_27294783_Chip-Seq_ESCs_Mouse0.74190029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.69234252
2MP0002837_dystrophic_cardiac_calcinosis5.31177995
3MP0005623_abnormal_meninges_morphology4.48744236
4MP0004084_abnormal_cardiac_muscle4.19230335
5MP0003279_aneurysm3.71323663
6MP0001915_intracranial_hemorrhage3.43644598
7MP0004145_abnormal_muscle_electrophysio2.44887851
8MP0003300_gastrointestinal_ulcer2.35469121
9MP0009379_abnormal_foot_pigmentation2.31241910
10MP0004036_abnormal_muscle_relaxation2.29613157
11MP0006054_spinal_hemorrhage10.8231735
12MP0001800_abnormal_humoral_immune1.97317870
13MP0009333_abnormal_splenocyte_physiolog1.93891308
14MP0001986_abnormal_taste_sensitivity1.86825748
15MP0004215_abnormal_myocardial_fiber1.79314580
16MP0004130_abnormal_muscle_cell1.78358112
17MP0010155_abnormal_intestine_physiology1.67731799
18MP0009785_altered_susceptibility_to1.65541376
19MP0004484_altered_response_of1.62262981
20MP0002163_abnormal_gland_morphology1.59172120
21MP0003303_peritoneal_inflammation1.57195449
22MP0000465_gastrointestinal_hemorrhage1.57070351
23MP0005671_abnormal_response_to1.52215466
24MP0002723_abnormal_immune_serum1.51303292
25MP0001348_abnormal_lacrimal_gland1.45859899
26MP0009765_abnormal_xenobiotic_induced1.42178552
27MP0000767_abnormal_smooth_muscle1.32764454
28MP0000703_abnormal_thymus_morphology1.27890730
29MP0005220_abnormal_exocrine_pancreas1.26008320
30MP0003186_abnormal_redox_activity1.24452660
31MP0003763_abnormal_thymus_physiology1.23960665
32MP0001835_abnormal_antigen_presentation1.22593777
33MP0004742_abnormal_vestibular_system1.20861266
34MP0000685_abnormal_immune_system1.20374909
35MP0002452_abnormal_antigen_presenting1.18069994
36MP0003724_increased_susceptibility_to1.17935161
37MP0005000_abnormal_immune_tolerance1.17706738
38MP0002693_abnormal_pancreas_physiology1.15488424
39MP0009780_abnormal_chondrocyte_physiolo1.13883620
40MP0000678_abnormal_parathyroid_gland1.13835988
41MP0002420_abnormal_adaptive_immunity1.13431869
42MP0003633_abnormal_nervous_system1.13254841
43MP0002419_abnormal_innate_immunity1.11412791
44MP0001819_abnormal_immune_cell1.11199150
45MP0003866_abnormal_defecation1.10096067
46MP0005387_immune_system_phenotype1.08952228
47MP0001790_abnormal_immune_system1.08952228
48MP0001764_abnormal_homeostasis1.07543472
49MP0001845_abnormal_inflammatory_respons1.06247460
50MP0003195_calcinosis1.04287071
51MP0002398_abnormal_bone_marrow1.04074300
52MP0001346_abnormal_lacrimal_gland1.03651919
53MP0000569_abnormal_digit_pigmentation0.99955188
54MP0002722_abnormal_immune_system0.99392056
55MP0005025_abnormal_response_to0.99252839
56MP0003183_abnormal_peptide_metabolism0.99046639
57MP0006292_abnormal_olfactory_placode0.96609165
58MP0000716_abnormal_immune_system0.94668853
59MP0005165_increased_susceptibility_to0.91589233
60MP0000689_abnormal_spleen_morphology0.89154247
61MP0001873_stomach_inflammation0.87612667
62MP0005379_endocrine/exocrine_gland_phen0.86917414
63MP0003631_nervous_system_phenotype0.85132748
64MP0000516_abnormal_urinary_system0.82559314
65MP0005367_renal/urinary_system_phenotyp0.82559314
66MP0002405_respiratory_system_inflammati0.80195184
67MP0001661_extended_life_span0.78753602
68MP0003646_muscle_fatigue0.77506199
69MP0002148_abnormal_hypersensitivity_rea0.76493938
70MP0002429_abnormal_blood_cell0.75641017
71MP0005448_abnormal_energy_balance0.73141980
72MP0008775_abnormal_heart_ventricle0.72753841
73MP0005266_abnormal_metabolism0.71411900
74MP0009763_increased_sensitivity_to0.67301445
75MP0005376_homeostasis/metabolism_phenot0.63925012
76MP0009250_abnormal_appendicular_skeleto0.63547889
77MP0001544_abnormal_cardiovascular_syste0.61657483
78MP0005385_cardiovascular_system_phenoty0.61657483
79MP0005334_abnormal_fat_pad0.61461820
80MP0006082_CNS_inflammation0.61411104
81MP0001501_abnormal_sleep_pattern0.60574711
82MP0003567_abnormal_fetal_cardiomyocyte0.55560025
83MP0003011_delayed_dark_adaptation0.55528733
84MP0008469_abnormal_protein_level0.53499264
85MP0004381_abnormal_hair_follicle0.53192439
86MP0001340_abnormal_eyelid_morphology0.50603521
87MP0002972_abnormal_cardiac_muscle0.49803337
88MP0002896_abnormal_bone_mineralization0.47657984
89MP0002106_abnormal_muscle_physiology0.47260716
90MP0000609_abnormal_liver_physiology0.45701354
91MP0002277_abnormal_respiratory_mucosa0.45325811
92MP0005023_abnormal_wound_healing0.43882688
93MP0003252_abnormal_bile_duct0.42558751
94MP0005584_abnormal_enzyme/coenzyme_acti0.42116911
95MP0000477_abnormal_intestine_morphology0.41952401
96MP0005647_abnormal_sex_gland0.41901374
97MP0003795_abnormal_bone_structure0.41706150
98MP0005197_abnormal_uvea_morphology0.41426658
99MP0001485_abnormal_pinna_reflex0.41420788
100MP0001286_abnormal_eye_development0.38165332

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)6.63356447
2Absent/shortened dynein arms (HP:0200106)6.07316602
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.07316602
4Stomatitis (HP:0010280)5.61226032
5Loss of speech (HP:0002371)5.60459566
6Chronic otitis media (HP:0000389)5.57307984
7Mutism (HP:0002300)5.48711518
8Premature ovarian failure (HP:0008209)5.41635129
9Hypergonadotropic hypogonadism (HP:0000815)5.39737284
10Abnormal number of erythroid precursors (HP:0012131)4.95452605
11Abnormality of cells of the erythroid lineage (HP:0012130)4.44679926
12B lymphocytopenia (HP:0010976)4.41488699
13Elevated erythrocyte sedimentation rate (HP:0003565)3.93102818
14Disinhibition (HP:0000734)3.90430231
15Abnormality of B cell number (HP:0010975)3.89448191
16Papilledema (HP:0001085)3.83852756
17Aortic regurgitation (HP:0001659)3.70511570
18Chronic sinusitis (HP:0011109)3.63737989
19Chronic diarrhea (HP:0002028)3.54316196
20Abnormal ciliary motility (HP:0012262)3.40384116
21Abnormal respiratory epithelium morphology (HP:0012253)3.28723346
22Abnormal respiratory motile cilium morphology (HP:0005938)3.28723346
23Dyskinesia (HP:0100660)3.23590135
24Hepatocellular necrosis (HP:0001404)3.21640646
25Inability to walk (HP:0002540)3.09428324
26Pseudobulbar signs (HP:0002200)2.97986605
27Agammaglobulinemia (HP:0004432)2.91579604
28Enlarged epiphyses (HP:0010580)2.85160731
29Renal cortical cysts (HP:0000803)2.77623945
30Rhinitis (HP:0012384)2.61371492
31IgG deficiency (HP:0004315)2.59099736
32Increased IgM level (HP:0003496)2.58839597
33Sepsis (HP:0100806)2.55767876
34T lymphocytopenia (HP:0005403)2.54658142
35Elfin facies (HP:0004428)2.48491662
36Porencephaly (HP:0002132)2.47050949
37Thin bony cortex (HP:0002753)2.42970330
38Abnormal respiratory motile cilium physiology (HP:0012261)2.39378355
39Progressive muscle weakness (HP:0003323)2.39306573
40Cleft eyelid (HP:0000625)2.37207593
41Conical tooth (HP:0000698)2.33870636
42Acute necrotizing encephalopathy (HP:0006965)2.33153365
43Delayed epiphyseal ossification (HP:0002663)2.32958303
44Abnormality of T cell number (HP:0011839)2.27842038
45Progressive macrocephaly (HP:0004481)2.26777535
46Severe combined immunodeficiency (HP:0004430)2.26051606
47Mitral regurgitation (HP:0001653)2.22975329
48Hepatic necrosis (HP:0002605)2.20554993
49Widely patent fontanelles and sutures (HP:0004492)2.19545805
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.14249055
51Hypoplastic ischia (HP:0003175)2.12885139
52Personality changes (HP:0000751)2.11521012
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09282885
54Abnormal mitochondria in muscle tissue (HP:0008316)2.08922232
55Mitochondrial inheritance (HP:0001427)2.04977652
56Bulbous nose (HP:0000414)2.02649925
57Thyroiditis (HP:0100646)2.02419290
58Abnormality of oral frenula (HP:0000190)2.01398312
59Renovascular hypertension (HP:0100817)2.00164388
60Abnormality of the costochondral junction (HP:0000919)2.00111351
61Chronic hepatic failure (HP:0100626)10.9088593
62Overriding aorta (HP:0002623)1.99980720
63Submucous cleft hard palate (HP:0000176)1.99181945
64Pallor (HP:0000980)1.97076852
65Abnormal foot bone ossification (HP:0010675)1.96965534
66Systemic lupus erythematosus (HP:0002725)1.95731653
67Leukodystrophy (HP:0002415)1.92569675
68Pustule (HP:0200039)1.91877964
69Stereotypic behavior (HP:0000733)1.91320964
70Pancytopenia (HP:0001876)1.90715173
71Flat cornea (HP:0007720)1.90630206
72Inappropriate behavior (HP:0000719)1.90126256
73Renal duplication (HP:0000075)1.88106596
74Supernumerary bones of the axial skeleton (HP:0009144)1.83496339
75Hyperacusis (HP:0010780)1.80927687
76Macrocytic anemia (HP:0001972)1.79897065
77Posterior subcapsular cataract (HP:0007787)1.79702131
78Methylmalonic acidemia (HP:0002912)1.79583655
79Restlessness (HP:0000711)1.79391477
80Metabolic acidosis (HP:0001942)1.79054017
81Apathy (HP:0000741)1.77798479
82Optic disc pallor (HP:0000543)1.76876450
83Combined immunodeficiency (HP:0005387)1.76340079
84Abnormality of the ischium (HP:0003174)1.75490305
85Constricted visual fields (HP:0001133)1.73410036
86Granulocytopenia (HP:0001913)1.72976139
87Abnormality of the nasal septum (HP:0000419)1.72772999
88Acute encephalopathy (HP:0006846)1.72403348
89Lymphopenia (HP:0001888)1.72282031
90Glomerulonephritis (HP:0000099)1.72202776
91Adducted thumb (HP:0001181)1.72101965
92Retrobulbar optic neuritis (HP:0100654)1.71858413
93Optic neuritis (HP:0100653)1.71858413
94Trigonocephaly (HP:0000243)1.70650800
95Abnormal hemoglobin (HP:0011902)1.69945691
96Bony spicule pigmentary retinopathy (HP:0007737)1.68550706
97Hypoplasia of the radius (HP:0002984)1.63739444
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.62630729
99Hypoplasia of the ulna (HP:0003022)1.62015457
100Increased hepatocellular lipid droplets (HP:0006565)1.59400327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.26900172
2MAP3K135.63629485
3CAMKK15.08708701
4MAP4K14.86763045
5RIPK43.11112808
6MAP3K142.54591583
7SIK22.43617119
8CAMKK22.08602347
9PASK10.2454484
10LRRK21.94809969
11ZAP701.66310304
12SCYL21.66163191
13BRSK21.55300887
14BTK1.43711169
15JAK31.38295218
16TYRO31.18205544
17SYK1.18183631
18MAP3K70.96941699
19TEC0.92186583
20LCK0.86697692
21ITK0.86221000
22MARK30.79590233
23IKBKB0.75139513
24PRKCQ0.73779699
25STK40.72446892
26NEK90.65373327
27CHUK0.62889386
28PTK60.60835121
29LYN0.57154740
30ADRBK20.56676161
31HCK0.56438885
32MAPKAPK30.55441893
33PAK60.53827796
34FES0.52830706
35STK380.51281164
36BRSK10.48842648
37CLK10.45543463
38FGR0.44283147
39BMPR1B0.44229912
40YES10.43576986
41NEK20.43576394
42CSK0.39937147
43JAK20.37665811
44IKBKE0.34285128
45SGK4940.33555810
46SGK2230.33555810
47ACVR1B0.32729784
48PRKCZ0.32620956
49PRKAA20.31106058
50TNIK0.30964323
51MAP4K20.30654433
52SIK30.28872858
53TLK10.27528123
54STK110.26873763
55PRKCD0.24368440
56PIK3CG0.23879178
57KIT0.23523753
58GRK60.22673176
59DMPK0.20874184
60BLK0.20736999
61GRK10.20427636
62SGK10.20277183
63GRK70.19728034
64RPS6KA50.19318672
65JAK10.19059840
66PDK10.18668422
67IGF1R0.18446511
68OBSCN0.16894598
69MAPK110.16510201
70ADRBK10.15924188
71MAPK130.15322117
72DYRK20.14837858
73TGFBR10.14567819
74INSRR0.14394790
75PAK20.14083234
76FYN0.14030693
77PAK30.12389721
78TAF10.11800013
79MAPKAPK20.10396692
80MAPK120.10149033
81MUSK0.09706151
82MAP2K30.08782835
83RPS6KA40.08665676
84MAP2K60.07903864
85MKNK20.07660887
86PRKACG0.05728946
87PRKCA0.04145973
88KDR0.03970697
89PAK10.03344506
90FRK0.03133995
91SIK10.02937549
92RPS6KA30.02881957
93TYK20.02168125
94RPS6KA10.02128006
95STK100.01563707
96CSNK1G30.01259861
97MAPK140.01110987
98MAPK30.00582424
99SRC0.00572427
100CSNK2A20.00210376

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.41798749
2Ribosome_Homo sapiens_hsa030104.08299965
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.00229668
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.82033216
5Allograft rejection_Homo sapiens_hsa053302.45507570
6Autoimmune thyroid disease_Homo sapiens_hsa053202.44453892
7Galactose metabolism_Homo sapiens_hsa000522.42665741
8T cell receptor signaling pathway_Homo sapiens_hsa046602.29061633
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.22246173
10Staphylococcus aureus infection_Homo sapiens_hsa051502.22043543
11Graft-versus-host disease_Homo sapiens_hsa053322.21949588
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.15624929
13Type I diabetes mellitus_Homo sapiens_hsa049402.10139283
14Primary immunodeficiency_Homo sapiens_hsa053402.07986518
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03419122
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96504753
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91372637
18Asthma_Homo sapiens_hsa053101.81960686
19Cocaine addiction_Homo sapiens_hsa050301.69317384
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.66550020
21Rheumatoid arthritis_Homo sapiens_hsa053231.63525510
22Prolactin signaling pathway_Homo sapiens_hsa049171.54828449
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47890258
24Glycerolipid metabolism_Homo sapiens_hsa005611.46706255
25Measles_Homo sapiens_hsa051621.44180268
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36013157
27Acute myeloid leukemia_Homo sapiens_hsa052211.35722206
28Sulfur metabolism_Homo sapiens_hsa009201.33104956
29Osteoclast differentiation_Homo sapiens_hsa043801.23658279
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21924790
31TNF signaling pathway_Homo sapiens_hsa046681.21576078
32Viral myocarditis_Homo sapiens_hsa054161.21416599
33B cell receptor signaling pathway_Homo sapiens_hsa046621.21068663
34Hematopoietic cell lineage_Homo sapiens_hsa046401.20195197
35Long-term potentiation_Homo sapiens_hsa047201.17526762
36Chemokine signaling pathway_Homo sapiens_hsa040621.13697128
37Amphetamine addiction_Homo sapiens_hsa050311.12841796
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04974149
39Hepatitis B_Homo sapiens_hsa051611.03337124
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02350327
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.01605506
42Regulation of autophagy_Homo sapiens_hsa041400.95417395
43Type II diabetes mellitus_Homo sapiens_hsa049300.93219924
44Shigellosis_Homo sapiens_hsa051310.92513879
45Apoptosis_Homo sapiens_hsa042100.89195199
46Antigen processing and presentation_Homo sapiens_hsa046120.86384884
47Leishmaniasis_Homo sapiens_hsa051400.84573887
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.82741289
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81799282
50Prostate cancer_Homo sapiens_hsa052150.80439789
51African trypanosomiasis_Homo sapiens_hsa051430.80212441
52HTLV-I infection_Homo sapiens_hsa051660.79974966
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78772631
54Tyrosine metabolism_Homo sapiens_hsa003500.78667578
55Thyroid hormone synthesis_Homo sapiens_hsa049180.74582950
56Viral carcinogenesis_Homo sapiens_hsa052030.73748255
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.73716949
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72638784
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71542285
60Influenza A_Homo sapiens_hsa051640.67635828
61Insulin secretion_Homo sapiens_hsa049110.66683867
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65861624
63Insulin resistance_Homo sapiens_hsa049310.64167883
64GnRH signaling pathway_Homo sapiens_hsa049120.64148981
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61765108
66TGF-beta signaling pathway_Homo sapiens_hsa043500.60483149
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59668916
68Nitrogen metabolism_Homo sapiens_hsa009100.55872199
69Glucagon signaling pathway_Homo sapiens_hsa049220.52352401
70Pertussis_Homo sapiens_hsa051330.51984757
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51466930
72Lysosome_Homo sapiens_hsa041420.50334329
73MAPK signaling pathway_Homo sapiens_hsa040100.49929218
74cAMP signaling pathway_Homo sapiens_hsa040240.48937160
75Malaria_Homo sapiens_hsa051440.48816802
76Tuberculosis_Homo sapiens_hsa051520.47451247
77Cholinergic synapse_Homo sapiens_hsa047250.46485672
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43021721
79Toxoplasmosis_Homo sapiens_hsa051450.42779292
80Complement and coagulation cascades_Homo sapiens_hsa046100.42154958
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.41629902
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40355944
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39704968
84PPAR signaling pathway_Homo sapiens_hsa033200.37904999
85Estrogen signaling pathway_Homo sapiens_hsa049150.37717834
86Systemic lupus erythematosus_Homo sapiens_hsa053220.37551695
87Herpes simplex infection_Homo sapiens_hsa051680.36629594
88Collecting duct acid secretion_Homo sapiens_hsa049660.36276390
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35380280
90Phagosome_Homo sapiens_hsa041450.33975680
91Caffeine metabolism_Homo sapiens_hsa002320.32353069
92Steroid biosynthesis_Homo sapiens_hsa001000.26585634
93Olfactory transduction_Homo sapiens_hsa047400.25526483
94p53 signaling pathway_Homo sapiens_hsa041150.25375505
95Taste transduction_Homo sapiens_hsa047420.24679106
96Morphine addiction_Homo sapiens_hsa050320.22522444
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22508335
98ABC transporters_Homo sapiens_hsa020100.20989895
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19120085
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.18122395

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