TRAV38-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)7.46997645
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.45778382
3positive regulation of gamma-delta T cell activation (GO:0046645)6.24671846
4leukocyte aggregation (GO:0070486)6.21992178
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.87012844
6negative T cell selection (GO:0043383)5.81119433
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.70763261
8negative thymic T cell selection (GO:0045060)5.69628557
9regulation of regulatory T cell differentiation (GO:0045589)5.66620310
10DNA deamination (GO:0045006)5.53191314
11cytidine metabolic process (GO:0046087)5.26888902
12cytidine catabolic process (GO:0006216)5.26888902
13cytidine deamination (GO:0009972)5.26888902
14regulation of B cell receptor signaling pathway (GO:0050855)5.23978142
15regulation of gamma-delta T cell differentiation (GO:0045586)5.17110449
16cellular response to interleukin-15 (GO:0071350)4.97372502
17negative regulation of cell killing (GO:0031342)4.96866428
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.96866428
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.94848492
20response to interleukin-15 (GO:0070672)4.89046128
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85609905
22regulation of T cell receptor signaling pathway (GO:0050856)4.85506586
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.79643362
24thymic T cell selection (GO:0045061)4.76960233
25hepatocyte apoptotic process (GO:0097284)4.76337947
26regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.69586254
27T cell selection (GO:0045058)4.63256494
28regulation of gamma-delta T cell activation (GO:0046643)4.62088085
29regulation of isotype switching to IgG isotypes (GO:0048302)4.49411692
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.49410868
31endothelial tube morphogenesis (GO:0061154)4.38448078
32morphogenesis of an endothelium (GO:0003159)4.38448078
33positive regulation of T cell mediated cytotoxicity (GO:0001916)4.36205437
34positive T cell selection (GO:0043368)4.31499337
35antigen processing and presentation of endogenous antigen (GO:0019883)4.26191176
36regulation of T cell tolerance induction (GO:0002664)4.16566239
37regulation of T cell mediated cytotoxicity (GO:0001914)4.16318377
38negative regulation of T cell mediated immunity (GO:0002710)4.10653204
39positive thymic T cell selection (GO:0045059)3.99039635
40T cell receptor signaling pathway (GO:0050852)3.96291589
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.93447418
42regulation of alpha-beta T cell proliferation (GO:0046640)3.86322568
43microtubule severing (GO:0051013)3.80133696
44positive regulation of alpha-beta T cell proliferation (GO:0046641)3.77264557
45positive regulation of tolerance induction (GO:0002645)3.76372641
46regulation of interleukin-2 biosynthetic process (GO:0045076)3.76142310
47positive regulation of T cell mediated immunity (GO:0002711)3.69865294
48positive regulation of cell killing (GO:0031343)3.69434221
49regulation of leukocyte mediated cytotoxicity (GO:0001910)3.69287258
50antigen processing and presentation via MHC class Ib (GO:0002475)3.61773028
51alpha-beta T cell differentiation (GO:0046632)3.60663711
52positive regulation of interleukin-2 production (GO:0032743)3.59126049
53activated T cell proliferation (GO:0050798)3.58406271
54antigen receptor-mediated signaling pathway (GO:0050851)3.56066348
55positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.54299866
56regulation of natural killer cell mediated immunity (GO:0002715)3.54242198
57regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.54242198
58regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.53175386
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.52781205
60negative regulation of B cell activation (GO:0050869)3.52528336
61T cell migration (GO:0072678)3.50484757
62negative regulation of adaptive immune response (GO:0002820)3.49610801
63regulation of cell killing (GO:0031341)3.47987802
64regulation of tolerance induction (GO:0002643)3.46383564
65T cell differentiation involved in immune response (GO:0002292)3.45702887
66alpha-beta T cell differentiation involved in immune response (GO:0002293)3.45702887
67alpha-beta T cell activation involved in immune response (GO:0002287)3.45702887
68T-helper cell differentiation (GO:0042093)3.44146105
69CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.44146105
70NIK/NF-kappaB signaling (GO:0038061)3.43812139
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41742251
72positive regulation of natural killer cell mediated immunity (GO:0002717)3.36531022
73positive regulation of isotype switching (GO:0045830)3.33279607
74positive regulation of cell fate commitment (GO:0010455)3.29277606
75alpha-beta T cell activation (GO:0046631)3.27568942
76regulation of T cell mediated immunity (GO:0002709)3.25722372
77positive regulation of lymphocyte mediated immunity (GO:0002708)3.23333305
78positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.22803707
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.22717539
80mast cell activation (GO:0045576)3.21697365
81positive regulation of DNA recombination (GO:0045911)3.17668222
82T cell differentiation (GO:0030217)3.17338002
83negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.16930012
84interferon-gamma production (GO:0032609)3.16831523
85positive regulation of granulocyte differentiation (GO:0030854)3.14817878
86regulation of B cell differentiation (GO:0045577)3.13899968
87regulation of alpha-beta T cell activation (GO:0046634)3.12585535
88lymph node development (GO:0048535)3.12299182
89positive regulation of alpha-beta T cell activation (GO:0046635)3.12038638
90positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.10648939
91positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.08597479
92regulation of fibroblast apoptotic process (GO:2000269)3.03300300
93CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.02851309
94regulation of interleukin-2 production (GO:0032663)3.02660605
95positive regulation of immunoglobulin mediated immune response (GO:0002891)3.01923123
96positive regulation of B cell mediated immunity (GO:0002714)3.01923123
97T cell homeostasis (GO:0043029)3.00656058
98regulation of isotype switching (GO:0045191)3.00653061
99mucosal-associated lymphoid tissue development (GO:0048537)2.99202651
100Peyers patch development (GO:0048541)2.99202651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.99941347
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.77841786
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.59134031
4RUNX_20019798_ChIP-Seq_JUKART_Human4.21260900
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.56984184
6MYB_26560356_Chip-Seq_TH2_Human3.50858373
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.41548979
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41168979
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.32549542
10NOTCH1_21737748_ChIP-Seq_TLL_Human3.03711347
11MYB_26560356_Chip-Seq_TH1_Human2.94841517
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.92561643
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80999855
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64440052
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62201417
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57529445
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41506684
18MAF_26560356_Chip-Seq_TH1_Human2.40747581
19GATA3_27048872_Chip-Seq_THYMUS_Human2.22717625
20SPI1_23547873_ChIP-Seq_NB4_Human2.20659545
21GATA3_26560356_Chip-Seq_TH2_Human2.12993967
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08135373
23MAF_26560356_Chip-Seq_TH2_Human2.06213249
24UTX_26944678_Chip-Seq_JUKART_Human2.02761442
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94433623
26VDR_23849224_ChIP-Seq_CD4+_Human1.90970009
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.88795512
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.86067800
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84478444
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.83433794
31MYC_22102868_ChIP-Seq_BL_Human1.78284345
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.76088521
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.76073073
34RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.70933130
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69947118
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68920081
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66331660
38SCL_19346495_ChIP-Seq_HPC-7_Human1.58289053
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56954721
40FOXP3_21729870_ChIP-Seq_TREG_Human1.53130270
41CIITA_25753668_ChIP-Seq_RAJI_Human1.43047372
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41719286
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41465054
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37710023
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33430745
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33266629
47VDR_24763502_ChIP-Seq_THP-1_Human1.27579638
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27383821
49SPI1_23127762_ChIP-Seq_K562_Human1.27122597
50GATA1_22025678_ChIP-Seq_K562_Human1.26774896
51GATA3_26560356_Chip-Seq_TH1_Human1.24162703
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23718457
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22158757
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18324573
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16743606
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10973648
57FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07272938
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05071859
59TCF7_22412390_ChIP-Seq_EML_Mouse1.04213707
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01314171
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.01057828
62ELK1_19687146_ChIP-ChIP_HELA_Human0.99224092
63PU_27001747_Chip-Seq_BMDM_Mouse0.98120644
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97904086
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97451790
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96448534
67PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95660622
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94794938
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94628421
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94628421
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94628421
72VDR_21846776_ChIP-Seq_THP-1_Human0.94612156
73YY1_21170310_ChIP-Seq_MESCs_Mouse0.93863489
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93794988
75PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93764165
76ELK1_22589737_ChIP-Seq_MCF10A_Human0.93580444
77VDR_24787735_ChIP-Seq_THP-1_Human0.93505709
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92343277
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88937643
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88633405
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86835043
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86371140
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84184779
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83408502
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82993260
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82900203
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82355532
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.80792019
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80188395
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79020169
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.77080597
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.76474195
93ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74992216
94CEBPB_22108803_ChIP-Seq_LS180_Human0.74525427
95EST1_17652178_ChIP-ChIP_JURKAT_Human0.74395880
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74092611
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73634156
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.73470895
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73461159
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73359070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.93845585
2MP0005671_abnormal_response_to4.16513087
3MP0003436_decreased_susceptibility_to3.92919758
4MP0001790_abnormal_immune_system3.31404983
5MP0005387_immune_system_phenotype3.31404983
6MP0005000_abnormal_immune_tolerance3.25380919
7MP0001800_abnormal_humoral_immune3.16209512
8MP0001873_stomach_inflammation3.10800259
9MP0001835_abnormal_antigen_presentation2.93040358
10MP0009333_abnormal_splenocyte_physiolog2.88388213
11MP0000685_abnormal_immune_system2.87991180
12MP0003724_increased_susceptibility_to2.85275702
13MP0002148_abnormal_hypersensitivity_rea2.81219389
14MP0002138_abnormal_hepatobiliary_system2.76525039
15MP0002723_abnormal_immune_serum2.55914010
16MP0009785_altered_susceptibility_to2.51729332
17MP0003866_abnormal_defecation2.38670439
18MP0004381_abnormal_hair_follicle2.37096782
19MP0002420_abnormal_adaptive_immunity2.35375331
20MP0001819_abnormal_immune_cell2.32899285
21MP0000703_abnormal_thymus_morphology2.29916401
22MP0005025_abnormal_response_to2.26661680
23MP0002452_abnormal_antigen_presenting2.26567987
24MP0002405_respiratory_system_inflammati2.18490042
25MP0002398_abnormal_bone_marrow2.15893209
26MP0002009_preneoplasia2.14454177
27MP0002877_abnormal_melanocyte_morpholog2.09761446
28MP0000716_abnormal_immune_system1.98487412
29MP0003300_gastrointestinal_ulcer1.92871952
30MP0002166_altered_tumor_susceptibility1.89240437
31MP0010155_abnormal_intestine_physiology1.88528870
32MP0000689_abnormal_spleen_morphology1.81100520
33MP0005310_abnormal_salivary_gland1.80887238
34MP0004947_skin_inflammation1.79927392
35MP0002722_abnormal_immune_system1.79763141
36MP0002419_abnormal_innate_immunity1.75872085
37MP0005075_abnormal_melanosome_morpholog1.71603839
38MP0002102_abnormal_ear_morphology1.70407638
39MP0000490_abnormal_crypts_of1.66478571
40MP0005377_hearing/vestibular/ear_phenot1.55341835
41MP0003878_abnormal_ear_physiology1.55341835
42MP0002429_abnormal_blood_cell1.54460142
43MP0001845_abnormal_inflammatory_respons1.53042612
44MP0001533_abnormal_skeleton_physiology1.51625222
45MP0006082_CNS_inflammation1.48963063
46MP0001348_abnormal_lacrimal_gland1.48419330
47MP0002163_abnormal_gland_morphology1.47820149
48MP0002277_abnormal_respiratory_mucosa1.39094657
49MP0000371_diluted_coat_color1.31824585
50MP0003303_peritoneal_inflammation1.31622558
51MP0000465_gastrointestinal_hemorrhage1.30279599
52MP0008260_abnormal_autophagy1.24523769
53MP0002006_tumorigenesis1.23328334
54MP0002933_joint_inflammation1.18353832
55MP0001663_abnormal_digestive_system1.17350014
56MP0003567_abnormal_fetal_cardiomyocyte1.16873211
57MP0005464_abnormal_platelet_physiology1.13125702
58MP0008057_abnormal_DNA_replication1.11928832
59MP0002876_abnormal_thyroid_physiology1.07482964
60MP0008469_abnormal_protein_level1.05709082
61MP0000569_abnormal_digit_pigmentation1.00304304
62MP0003448_altered_tumor_morphology0.97031870
63MP0005084_abnormal_gallbladder_morpholo0.95820959
64MP0005167_abnormal_blood-brain_barrier0.86742671
65MP0002693_abnormal_pancreas_physiology0.85838834
66MP0000858_altered_metastatic_potential0.85567109
67MP0005379_endocrine/exocrine_gland_phen0.83778989
68MP0002998_abnormal_bone_remodeling0.83276657
69MP0001853_heart_inflammation0.81893654
70MP0005076_abnormal_cell_differentiation0.81137426
71MP0005645_abnormal_hypothalamus_physiol0.79182176
72MP0001765_abnormal_ion_homeostasis0.78017724
73MP0000604_amyloidosis0.74561227
74MP0001851_eye_inflammation0.73096405
75MP0009764_decreased_sensitivity_to0.72850967
76MP0001346_abnormal_lacrimal_gland0.72710105
77MP0003172_abnormal_lysosome_physiology0.69095269
78MP0001919_abnormal_reproductive_system0.67510014
79MP0005381_digestive/alimentary_phenotyp0.65782654
80MP0002132_abnormal_respiratory_system0.63426924
81MP0005390_skeleton_phenotype0.63399564
82MP0003943_abnormal_hepatobiliary_system0.61977928
83MP0009763_increased_sensitivity_to0.61913323
84MP0002019_abnormal_tumor_incidence0.61432242
85MP0001216_abnormal_epidermal_layer0.57357689
86MP0003950_abnormal_plasma_membrane0.57275383
87MP0003045_fibrosis0.56878902
88MP0004742_abnormal_vestibular_system0.55906695
89MP0005365_abnormal_bile_salt0.52706902
90MP0001879_abnormal_lymphatic_vessel0.51923506
91MP0000609_abnormal_liver_physiology0.51367494
92MP0008872_abnormal_physiological_respon0.49815044
93MP0001243_abnormal_dermal_layer0.48762019
94MP0001191_abnormal_skin_condition0.48180343
95MP0000477_abnormal_intestine_morphology0.47513332
96MP0002396_abnormal_hematopoietic_system0.46891151
97MP0003795_abnormal_bone_structure0.46353566
98MP0005408_hypopigmentation0.46133037
99MP0001188_hyperpigmentation0.45281856
100MP0002136_abnormal_kidney_physiology0.44899475

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.67498343
2Autoimmune hemolytic anemia (HP:0001890)6.27885542
3Increased IgM level (HP:0003496)5.88331138
4Elevated erythrocyte sedimentation rate (HP:0003565)5.34137246
5IgG deficiency (HP:0004315)4.84926033
6Abnormality of T cell number (HP:0011839)4.82864397
7Mediastinal lymphadenopathy (HP:0100721)4.39946760
8T lymphocytopenia (HP:0005403)4.27398050
9Gastrointestinal infarctions (HP:0005244)4.27157523
10Abnormality of T cells (HP:0002843)4.07245162
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.94128689
12Pulmonary infiltrates (HP:0002113)3.94090395
13Autoimmune thrombocytopenia (HP:0001973)3.83152185
14Myositis (HP:0100614)3.77936660
15IgM deficiency (HP:0002850)3.74000299
16Severe combined immunodeficiency (HP:0004430)3.63862116
17Abnormality of T cell physiology (HP:0011840)3.63626889
18Abnormality of eosinophils (HP:0001879)3.43251373
19Vasculitis (HP:0002633)3.42125092
20Joint swelling (HP:0001386)3.41395630
21Abnormality of the prostate (HP:0008775)3.40810044
22Adactyly (HP:0009776)3.40683939
23Eczematoid dermatitis (HP:0000976)3.21424753
24Retrobulbar optic neuritis (HP:0100654)3.18949674
25Optic neuritis (HP:0100653)3.18949674
26Eosinophilia (HP:0001880)3.17684776
27Abnormality of B cell number (HP:0010975)3.13753883
28Abnormality of cells of the lymphoid lineage (HP:0012140)3.06759329
29Abnormality of the pons (HP:0007361)3.05138417
30Granulocytopenia (HP:0001913)3.04958247
31Recurrent fungal infections (HP:0002841)3.04822802
32Meningitis (HP:0001287)3.03895722
33Obstructive lung disease (HP:0006536)2.99701171
34Chronic obstructive pulmonary disease (HP:0006510)2.99701171
35Leukocytosis (HP:0001974)2.96808826
36Orchitis (HP:0100796)2.93634191
37Lymphopenia (HP:0001888)2.90283459
38Encephalitis (HP:0002383)2.89534022
39Pustule (HP:0200039)2.84641853
40Porencephaly (HP:0002132)2.84391732
41Recurrent viral infections (HP:0004429)2.84174081
42Hypochromic anemia (HP:0001931)2.79054019
43Recurrent bronchitis (HP:0002837)2.78330879
44Pulmonary fibrosis (HP:0002206)2.73457217
45Hypergammaglobulinemia (HP:0010702)2.72551586
46Chest pain (HP:0100749)2.70621646
47Hemoptysis (HP:0002105)2.69974451
48Combined immunodeficiency (HP:0005387)2.69094777
49Recurrent bacterial skin infections (HP:0005406)2.65617170
50Gangrene (HP:0100758)2.64752611
51B lymphocytopenia (HP:0010976)2.59780454
52Chronic diarrhea (HP:0002028)2.59167814
53Alveolar cell carcinoma (HP:0006519)2.55118199
54Hypoplasia of the pons (HP:0012110)2.50841571
55Pulmonary embolism (HP:0002204)2.49433643
56Impaired proprioception (HP:0010831)2.49122408
57Thyroiditis (HP:0100646)2.47562812
58Genetic anticipation (HP:0003743)2.46549819
59Lymphoma (HP:0002665)2.44407810
60Neoplasm of the tracheobronchial system (HP:0100552)2.40036060
61Recurrent abscess formation (HP:0002722)2.38205444
62Acute hepatic failure (HP:0006554)2.36982249
63Stomach cancer (HP:0012126)2.35656114
64Axonal loss (HP:0003447)2.35353057
65Testicular atrophy (HP:0000029)2.34581157
66Abnormality of macrophages (HP:0004311)2.34460539
67Ureteral stenosis (HP:0000071)2.31106658
68Basal cell carcinoma (HP:0002671)2.27303018
69Keratoconjunctivitis sicca (HP:0001097)2.22653825
70Segmental peripheral demyelination/remyelination (HP:0003481)2.21340469
71Abnormality of the pleura (HP:0002103)2.21305408
72Anorexia (HP:0002039)2.20792864
73Absent hand (HP:0004050)2.20295597
74Gastrointestinal inflammation (HP:0004386)2.18794384
75Papilledema (HP:0001085)2.15061399
76Urticaria (HP:0001025)2.13302919
77Ureteral obstruction (HP:0006000)2.11065803
78Aplastic anemia (HP:0001915)2.10557959
79Dyschromatopsia (HP:0007641)2.09236443
80Keratoconjunctivitis (HP:0001096)2.06252623
81Diplopia (HP:0000651)2.04555049
82Abnormality of binocular vision (HP:0011514)2.04555049
83Hypoproteinemia (HP:0003075)2.04454746
84Metaphyseal dysplasia (HP:0100255)2.03360820
85Arterial thrombosis (HP:0004420)2.02266100
86Glomerulopathy (HP:0100820)2.00400031
87Syringomyelia (HP:0003396)1.98179449
88Spinal cord lesions (HP:0100561)1.98179449
89Hypochromic microcytic anemia (HP:0004840)1.95827682
90Recurrent cutaneous fungal infections (HP:0011370)1.95707937
91Chronic mucocutaneous candidiasis (HP:0002728)1.95707937
92Inflammation of the large intestine (HP:0002037)1.92338992
93Epistaxis (HP:0000421)1.90168016
94Pancytopenia (HP:0001876)1.88758283
95Cortical visual impairment (HP:0100704)1.88535350
96Abnormality of dental color (HP:0011073)1.88303023
97Supernumerary bones of the axial skeleton (HP:0009144)1.87976752
98Polyneuropathy (HP:0001271)1.86843298
99Deep palmar crease (HP:0006191)1.86750275
100Abnormality of male internal genitalia (HP:0000022)1.82034600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.88890245
2MST45.22796797
3MAP4K15.03872360
4SIK34.71154557
5TRIM282.31363140
6DAPK22.28705995
7TSSK62.27555076
8PIK3CG2.23566311
9MAP3K142.19069744
10ITK2.16903591
11TAF12.10342866
12MAP3K131.97627245
13BCR1.95865635
14IKBKE1.90602512
15CSK1.86294541
16GRK61.71510430
17FES1.68191604
18BTK1.63275924
19TYK21.58396814
20LCK1.54029629
21MAP3K111.53888444
22SYK1.47171511
23JAK31.46201932
24TEC1.44770593
25PASK1.43822994
26NLK1.42700177
27RIPK41.39022718
28FGFR31.37650067
29DYRK21.36099565
30HCK1.27182225
31ZAP701.25534821
32JAK11.23343158
33CDK81.22642911
34TNK21.22080264
35IKBKB1.21312480
36SIK21.18539026
37PRKCQ1.15254122
38MAPK111.10595392
39LYN1.08391120
40MAP3K121.02661659
41MAP2K30.96559551
42MARK30.93973534
43TAOK30.87628023
44FGFR40.87288981
45CAMKK20.85629367
46TAOK10.85565186
47DAPK10.81553142
48IRAK40.80102539
49PRPF4B0.79325691
50MAPKAPK20.78456896
51TBK10.76303854
52SCYL20.74535360
53MAP3K90.71860386
54JAK20.67288190
55BLK0.67108263
56PDK10.63960693
57PIM10.63401644
58EPHA30.60337651
59EPHB10.58033857
60CSF1R0.54480680
61PDK20.53677381
62STK100.51510863
63MAP3K10.48879517
64CAMKK10.48715473
65MAP2K60.48170827
66VRK20.47233870
67CHUK0.45928281
68FYN0.45673451
69MELK0.43281354
70MAP3K50.41944902
71CASK0.39987661
72NEK60.39309129
73KSR10.39177963
74ADRBK20.37706352
75PTK2B0.36199299
76ALK0.35867507
77RPS6KB10.35613439
78IGF1R0.34606610
79STK390.33364085
80TYRO30.33026806
81HIPK20.32153720
82SIK10.30898739
83RPS6KA40.30150788
84WNK40.30015495
85EIF2AK30.29692494
86PRKCD0.26870764
87NUAK10.26755195
88MAP3K30.26647108
89MAPK90.25213701
90SMG10.24954654
91KIT0.24877939
92TAOK20.24602584
93CAMK1D0.24442898
94PRKD20.21975831
95STK40.21783613
96OXSR10.21447762
97DAPK30.21412244
98MARK20.21009622
99CSNK1A1L0.19750353
100SGK20.18441169

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.47077674
2T cell receptor signaling pathway_Homo sapiens_hsa046603.97245412
3Autoimmune thyroid disease_Homo sapiens_hsa053203.15849596
4Allograft rejection_Homo sapiens_hsa053303.14882812
5Measles_Homo sapiens_hsa051623.07412801
6Graft-versus-host disease_Homo sapiens_hsa053322.91331880
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.82494448
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52547879
9Type I diabetes mellitus_Homo sapiens_hsa049402.44628109
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.34845341
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.34643803
12Hematopoietic cell lineage_Homo sapiens_hsa046402.23877057
13B cell receptor signaling pathway_Homo sapiens_hsa046622.15558095
14Osteoclast differentiation_Homo sapiens_hsa043802.05074754
15RNA degradation_Homo sapiens_hsa030182.01305782
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.95788686
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74922492
18Antigen processing and presentation_Homo sapiens_hsa046121.74719633
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61148564
20Acute myeloid leukemia_Homo sapiens_hsa052211.58337581
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54230163
22Epstein-Barr virus infection_Homo sapiens_hsa051691.53287851
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.50245277
24Hepatitis B_Homo sapiens_hsa051611.44839733
25Herpes simplex infection_Homo sapiens_hsa051681.44781469
26Regulation of autophagy_Homo sapiens_hsa041401.44670614
27Folate biosynthesis_Homo sapiens_hsa007901.42178431
28Leishmaniasis_Homo sapiens_hsa051401.41958317
29Shigellosis_Homo sapiens_hsa051311.39836492
30Viral myocarditis_Homo sapiens_hsa054161.39391038
31TNF signaling pathway_Homo sapiens_hsa046681.37503453
32Sulfur relay system_Homo sapiens_hsa041221.36992097
33Chemokine signaling pathway_Homo sapiens_hsa040621.31935803
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31142360
35Proteasome_Homo sapiens_hsa030501.28269804
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24694264
37Influenza A_Homo sapiens_hsa051641.18546577
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10806523
39Viral carcinogenesis_Homo sapiens_hsa052031.09434192
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08528323
41Apoptosis_Homo sapiens_hsa042101.07623621
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06852466
43Tuberculosis_Homo sapiens_hsa051521.04532217
44Legionellosis_Homo sapiens_hsa051341.01693489
45Toxoplasmosis_Homo sapiens_hsa051451.00172078
46Rheumatoid arthritis_Homo sapiens_hsa053230.98368961
47Non-small cell lung cancer_Homo sapiens_hsa052230.95467040
48African trypanosomiasis_Homo sapiens_hsa051430.94708873
49VEGF signaling pathway_Homo sapiens_hsa043700.92744403
50Asthma_Homo sapiens_hsa053100.90389571
51Staphylococcus aureus infection_Homo sapiens_hsa051500.81297442
52Protein export_Homo sapiens_hsa030600.81016408
53HTLV-I infection_Homo sapiens_hsa051660.77877180
54Hepatitis C_Homo sapiens_hsa051600.77597286
55Malaria_Homo sapiens_hsa051440.76939384
56Fatty acid biosynthesis_Homo sapiens_hsa000610.71592273
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71160374
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.69174690
59Thyroid cancer_Homo sapiens_hsa052160.68741516
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68633723
61Prolactin signaling pathway_Homo sapiens_hsa049170.67193011
62Pancreatic cancer_Homo sapiens_hsa052120.66820728
63Basal transcription factors_Homo sapiens_hsa030220.63872327
64Circadian rhythm_Homo sapiens_hsa047100.63516340
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.59888202
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54973631
67MAPK signaling pathway_Homo sapiens_hsa040100.52635701
68FoxO signaling pathway_Homo sapiens_hsa040680.51730777
69Colorectal cancer_Homo sapiens_hsa052100.49677298
70Platelet activation_Homo sapiens_hsa046110.49237640
71Dorso-ventral axis formation_Homo sapiens_hsa043200.39563694
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39263219
73Chronic myeloid leukemia_Homo sapiens_hsa052200.37813237
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.37395254
75RNA transport_Homo sapiens_hsa030130.35942742
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35520502
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35129477
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.34785851
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32154713
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31803596
81Spliceosome_Homo sapiens_hsa030400.31351650
82Glycerolipid metabolism_Homo sapiens_hsa005610.30169587
83Insulin resistance_Homo sapiens_hsa049310.29319859
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27635337
85Long-term potentiation_Homo sapiens_hsa047200.26221681
86Prostate cancer_Homo sapiens_hsa052150.25414531
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23654315
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23592049
89Collecting duct acid secretion_Homo sapiens_hsa049660.23072925
90Phagosome_Homo sapiens_hsa041450.22839815
91Endometrial cancer_Homo sapiens_hsa052130.22776259
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22754145
93Pertussis_Homo sapiens_hsa051330.21763611
94Endocytosis_Homo sapiens_hsa041440.21148847
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18404161
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16616004
97RNA polymerase_Homo sapiens_hsa030200.15489928
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14804720
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13790075
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.13297214

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