TRAV38-2DV8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)7.12849074
2negative T cell selection (GO:0043383)6.88938466
3negative thymic T cell selection (GO:0045060)6.65912741
4negative regulation of cell killing (GO:0031342)6.64340635
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.64340635
6positive regulation of gamma-delta T cell activation (GO:0046645)6.54015531
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.45580299
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.38621049
9regulation of regulatory T cell differentiation (GO:0045589)6.18907341
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.03523661
11response to interleukin-15 (GO:0070672)5.92389675
12cellular response to interleukin-15 (GO:0071350)5.84383179
13regulation of T cell tolerance induction (GO:0002664)5.53927415
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.50933755
15negative regulation of T cell mediated immunity (GO:0002710)5.49918035
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.45564165
17regulation of isotype switching to IgG isotypes (GO:0048302)5.45519784
18antigen processing and presentation of endogenous antigen (GO:0019883)5.42984439
19thymic T cell selection (GO:0045061)5.28863237
20regulation of gamma-delta T cell differentiation (GO:0045586)5.16804000
21T cell selection (GO:0045058)5.10058802
22regulation of B cell receptor signaling pathway (GO:0050855)5.09140633
23positive regulation of tolerance induction (GO:0002645)5.01790197
24regulation of interleukin-2 biosynthetic process (GO:0045076)4.89817535
25positive T cell selection (GO:0043368)4.83674506
26regulation of gamma-delta T cell activation (GO:0046643)4.82015649
27activated T cell proliferation (GO:0050798)4.80956065
28leukocyte aggregation (GO:0070486)4.68105365
29regulation of tolerance induction (GO:0002643)4.68034082
30negative regulation of lymphocyte mediated immunity (GO:0002707)4.61712432
31positive thymic T cell selection (GO:0045059)4.59475482
32T cell migration (GO:0072678)4.52264428
33regulation of alpha-beta T cell proliferation (GO:0046640)4.39805335
34positive regulation of granulocyte differentiation (GO:0030854)4.28294767
35T cell receptor signaling pathway (GO:0050852)4.11738970
36regulation of natural killer cell mediated immunity (GO:0002715)4.08567268
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.08567268
38positive regulation of alpha-beta T cell proliferation (GO:0046641)4.00185972
39alpha-beta T cell differentiation (GO:0046632)3.93000761
40T cell homeostasis (GO:0043029)3.92643192
41interferon-gamma production (GO:0032609)3.90833355
42regulation of T cell mediated cytotoxicity (GO:0001914)3.88790448
43negative regulation of leukocyte mediated immunity (GO:0002704)3.87105016
44antigen receptor-mediated signaling pathway (GO:0050851)3.84926937
45positive regulation of T cell differentiation in thymus (GO:0033089)3.82667201
46positive regulation of T cell mediated cytotoxicity (GO:0001916)3.81689548
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.69804405
48positive regulation of interleukin-4 production (GO:0032753)3.68779115
49positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.68359758
50NIK/NF-kappaB signaling (GO:0038061)3.67369523
51positive regulation of B cell differentiation (GO:0045579)3.66258080
52regulation of B cell differentiation (GO:0045577)3.64761697
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63313828
54regulation of leukocyte mediated cytotoxicity (GO:0001910)3.63141547
55positive regulation of natural killer cell mediated immunity (GO:0002717)3.61115134
56alpha-beta T cell activation (GO:0046631)3.57748260
57negative regulation of interleukin-12 production (GO:0032695)3.47130761
58negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.45737011
59mast cell activation (GO:0045576)3.45607104
60cellular response to type I interferon (GO:0071357)3.44791530
61type I interferon signaling pathway (GO:0060337)3.44791530
62positive regulation of interleukin-2 production (GO:0032743)3.42892295
63response to type I interferon (GO:0034340)3.40907627
64antigen processing and presentation via MHC class Ib (GO:0002475)3.40376614
65positive regulation of cell killing (GO:0031343)3.39406674
66regulation of interleukin-4 production (GO:0032673)3.37167106
67CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.35005926
68regulation of isotype switching (GO:0045191)3.33835882
69regulation of cell killing (GO:0031341)3.33341033
70negative regulation of adaptive immune response (GO:0002820)3.30693828
71positive regulation of T cell mediated immunity (GO:0002711)3.28597823
72regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.27852167
73T cell costimulation (GO:0031295)3.27342347
74detection of bacterium (GO:0016045)3.27179966
75positive regulation of humoral immune response (GO:0002922)3.26271993
76negative regulation of B cell mediated immunity (GO:0002713)3.24319216
77negative regulation of immunoglobulin mediated immune response (GO:0002890)3.24319216
78lymphocyte costimulation (GO:0031294)3.23007711
79lymphocyte migration (GO:0072676)3.21518979
80T cell differentiation (GO:0030217)3.21507606
81B cell receptor signaling pathway (GO:0050853)3.20314026
82negative regulation of cytokine production involved in immune response (GO:0002719)3.19047463
83positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.19014094
84regulation of interleukin-2 production (GO:0032663)3.18375721
85regulation of alpha-beta T cell activation (GO:0046634)3.18373504
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.17688756
87T-helper cell differentiation (GO:0042093)3.17688756
88regulation of T cell mediated immunity (GO:0002709)3.17202247
89positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.17132867
90detection of other organism (GO:0098543)3.17021822
91myeloid dendritic cell differentiation (GO:0043011)3.15472252
92regulation of T cell receptor signaling pathway (GO:0050856)3.13588865
93positive regulation of isotype switching (GO:0045830)3.10666981
94regulation of T cell cytokine production (GO:0002724)3.07904579
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07331983
96regulation of defense response to virus by virus (GO:0050690)3.06603953
97positive regulation of lymphocyte mediated immunity (GO:0002708)3.05481015
98CD4-positive, alpha-beta T cell activation (GO:0035710)3.03937639
99lymphocyte homeostasis (GO:0002260)3.03161290
100positive regulation of alpha-beta T cell activation (GO:0046635)3.02891443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.40471474
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.75818979
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.83420266
4RUNX_20019798_ChIP-Seq_JUKART_Human3.99867861
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.79979329
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.55036485
7MYB_26560356_Chip-Seq_TH2_Human3.47485857
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.38046692
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33037321
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30346744
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.18367413
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.02675594
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93366885
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.91575141
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89919614
16MAF_26560356_Chip-Seq_TH1_Human2.85053036
17MYB_26560356_Chip-Seq_TH1_Human2.78882766
18UTX_26944678_Chip-Seq_JUKART_Human2.50595118
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43758750
20SPI1_23547873_ChIP-Seq_NB4_Human2.32536322
21GATA3_27048872_Chip-Seq_THYMUS_Human2.30987292
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30622340
23MYC_22102868_ChIP-Seq_BL_Human2.30453625
24MAF_26560356_Chip-Seq_TH2_Human2.30295430
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.20671169
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19295830
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12583252
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11789756
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98168949
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96072985
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.90954638
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.88254717
33GATA3_26560356_Chip-Seq_TH2_Human1.79947072
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.75161817
35VDR_21846776_ChIP-Seq_THP-1_Human1.74042001
36SPI1_23127762_ChIP-Seq_K562_Human1.73420011
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72746413
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69020297
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68302445
40SCL_19346495_ChIP-Seq_HPC-7_Human1.67150104
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65266869
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61912103
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.61185600
44TCF7_22412390_ChIP-Seq_EML_Mouse1.60285900
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57395764
46VDR_24763502_ChIP-Seq_THP-1_Human1.55656803
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44202058
48CIITA_25753668_ChIP-Seq_RAJI_Human1.43967873
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37896570
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32374588
51VDR_23849224_ChIP-Seq_CD4+_Human1.32321015
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31786259
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30467487
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29707241
55KDM2B_26808549_Chip-Seq_DND41_Human1.29002538
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26849466
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24045540
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20359139
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19547510
60PU_27001747_Chip-Seq_BMDM_Mouse1.19414078
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.18808926
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18719675
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18382072
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17979415
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16060150
66FOXP3_21729870_ChIP-Seq_TREG_Human1.14514695
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11599771
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.10864106
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10163352
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09492107
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06782530
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00716940
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99477902
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99101144
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98476345
76PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98149597
77GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98067673
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96388965
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95962070
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.91844527
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90547401
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89720262
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89359056
84VDR_24787735_ChIP-Seq_THP-1_Human0.87878861
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86472169
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85488806
87GATA1_22025678_ChIP-Seq_K562_Human0.84797275
88GATA3_26560356_Chip-Seq_TH1_Human0.82837724
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82770848
90ELK3_25401928_ChIP-Seq_HUVEC_Human0.81965488
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80778301
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78310918
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76118720
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72716516
95GATA1_19941826_ChIP-Seq_K562_Human0.71964998
96NCOR1_26117541_ChIP-Seq_K562_Human0.71907367
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71339010
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.70340452
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.65328967
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64982828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.87693293
2MP0005671_abnormal_response_to4.48865790
3MP0003436_decreased_susceptibility_to3.65116192
4MP0001873_stomach_inflammation3.46433849
5MP0001835_abnormal_antigen_presentation3.37457204
6MP0001800_abnormal_humoral_immune3.37444923
7MP0009333_abnormal_splenocyte_physiolog3.21802906
8MP0001790_abnormal_immune_system3.21179333
9MP0005387_immune_system_phenotype3.21179333
10MP0003724_increased_susceptibility_to3.16470292
11MP0005000_abnormal_immune_tolerance3.15572639
12MP0000685_abnormal_immune_system2.87635790
13MP0002723_abnormal_immune_serum2.78024414
14MP0002420_abnormal_adaptive_immunity2.73579859
15MP0001819_abnormal_immune_cell2.68810126
16MP0003866_abnormal_defecation2.58567477
17MP0005025_abnormal_response_to2.58202810
18MP0002452_abnormal_antigen_presenting2.54516245
19MP0000703_abnormal_thymus_morphology2.51799847
20MP0009785_altered_susceptibility_to2.50120759
21MP0003303_peritoneal_inflammation2.47710438
22MP0002405_respiratory_system_inflammati2.45316979
23MP0002398_abnormal_bone_marrow2.44392035
24MP0002148_abnormal_hypersensitivity_rea2.40840532
25MP0003300_gastrointestinal_ulcer2.31810121
26MP0004381_abnormal_hair_follicle2.25584278
27MP0002419_abnormal_innate_immunity2.24079819
28MP0000716_abnormal_immune_system2.23358862
29MP0010155_abnormal_intestine_physiology2.23146460
30MP0000465_gastrointestinal_hemorrhage2.18011103
31MP0006082_CNS_inflammation2.08180770
32MP0002277_abnormal_respiratory_mucosa2.07528515
33MP0000689_abnormal_spleen_morphology2.02131638
34MP0004947_skin_inflammation2.00179066
35MP0002722_abnormal_immune_system1.98175224
36MP0005310_abnormal_salivary_gland1.88510073
37MP0002429_abnormal_blood_cell1.75952216
38MP0002166_altered_tumor_susceptibility1.74485272
39MP0005464_abnormal_platelet_physiology1.70819106
40MP0001845_abnormal_inflammatory_respons1.69116616
41MP0001851_eye_inflammation1.68940860
42MP0005075_abnormal_melanosome_morpholog1.60896085
43MP0008260_abnormal_autophagy1.58379086
44MP0001533_abnormal_skeleton_physiology1.53407376
45MP0001853_heart_inflammation1.45211242
46MP0002396_abnormal_hematopoietic_system1.45150060
47MP0002138_abnormal_hepatobiliary_system1.40317360
48MP0001348_abnormal_lacrimal_gland1.36692472
49MP0000490_abnormal_crypts_of1.31541479
50MP0002163_abnormal_gland_morphology1.25871869
51MP0002933_joint_inflammation1.25835534
52MP0008469_abnormal_protein_level1.22732476
53MP0002006_tumorigenesis1.15249320
54MP0002132_abnormal_respiratory_system1.12737780
55MP0001663_abnormal_digestive_system1.10476247
56MP0004510_myositis1.06259061
57MP0002009_preneoplasia1.05549138
58MP0003045_fibrosis0.98925936
59MP0000858_altered_metastatic_potential0.97669125
60MP0003172_abnormal_lysosome_physiology0.95226576
61MP0009764_decreased_sensitivity_to0.82992072
62MP0009763_increased_sensitivity_to0.81363406
63MP0003448_altered_tumor_morphology0.81124643
64MP0002998_abnormal_bone_remodeling0.81116806
65MP0003828_pulmonary_edema0.74694598
66MP0002019_abnormal_tumor_incidence0.71596191
67MP0002693_abnormal_pancreas_physiology0.70461939
68MP0003191_abnormal_cellular_cholesterol0.68267083
69MP0005451_abnormal_body_composition0.65208690
70MP0009278_abnormal_bone_marrow0.63212235
71MP0004883_abnormal_blood_vessel0.63196650
72MP0005381_digestive/alimentary_phenotyp0.62963362
73MP0000015_abnormal_ear_pigmentation0.59438834
74MP0004808_abnormal_hematopoietic_stem0.58962584
75MP0008961_abnormal_basal_metabolism0.58954729
76MP0002254_reproductive_system_inflammat0.58906686
77MP0005166_decreased_susceptibility_to0.58238083
78MP0004130_abnormal_muscle_cell0.56456755
79MP0005379_endocrine/exocrine_gland_phen0.55499211
80MP0000604_amyloidosis0.54585507
81MP0009765_abnormal_xenobiotic_induced0.53547651
82MP0005390_skeleton_phenotype0.51500812
83MP0001919_abnormal_reproductive_system0.49195498
84MP0000249_abnormal_blood_vessel0.49154543
85MP0008569_lethality_at_weaning0.47872637
86MP0003795_abnormal_bone_structure0.46041580
87MP0008057_abnormal_DNA_replication0.45150491
88MP0000609_abnormal_liver_physiology0.43272278
89MP0003091_abnormal_cell_migration0.43123065
90MP0008004_abnormal_stomach_pH0.39883113
91MP0008874_decreased_physiological_sensi0.39613516
92MP0008873_increased_physiological_sensi0.37491810
93MP0000372_irregular_coat_pigmentation0.35013158
94MP0001765_abnormal_ion_homeostasis0.34209665
95MP0003221_abnormal_cardiomyocyte_apopto0.34182737
96MP0005164_abnormal_response_to0.33741170
97MP0000367_abnormal_coat/_hair0.32756954
98MP0000477_abnormal_intestine_morphology0.32284268
99MP0003183_abnormal_peptide_metabolism0.30698179
100MP0002136_abnormal_kidney_physiology0.30660045

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.89775767
2T lymphocytopenia (HP:0005403)6.44688360
3Elevated erythrocyte sedimentation rate (HP:0003565)6.24051228
4Abnormality of T cell number (HP:0011839)6.03614735
5Autoimmune hemolytic anemia (HP:0001890)5.70452948
6Eczematoid dermatitis (HP:0000976)5.58130895
7Myositis (HP:0100614)5.00074689
8Abnormality of T cells (HP:0002843)4.83235535
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.44143324
10Severe combined immunodeficiency (HP:0004430)4.34834926
11Recurrent abscess formation (HP:0002722)4.29933691
12Recurrent bacterial skin infections (HP:0005406)4.27819444
13Recurrent fungal infections (HP:0002841)4.19060893
14Retrobulbar optic neuritis (HP:0100654)4.15690386
15Optic neuritis (HP:0100653)4.15690386
16IgG deficiency (HP:0004315)4.14281260
17Increased IgM level (HP:0003496)4.12372207
18Orchitis (HP:0100796)4.06470329
19Abnormality of macrophages (HP:0004311)3.96562296
20Mediastinal lymphadenopathy (HP:0100721)3.83992965
21Meningitis (HP:0001287)3.78500051
22Encephalitis (HP:0002383)3.77304726
23Gastrointestinal infarctions (HP:0005244)3.74402321
24Pulmonary infiltrates (HP:0002113)3.68647672
25Vasculitis (HP:0002633)3.59837811
26Chronic obstructive pulmonary disease (HP:0006510)3.59643543
27Obstructive lung disease (HP:0006536)3.59643543
28Chronic mucocutaneous candidiasis (HP:0002728)3.56192313
29Recurrent cutaneous fungal infections (HP:0011370)3.56192313
30Abnormality of T cell physiology (HP:0011840)3.54794905
31Pustule (HP:0200039)3.54553027
32Recurrent bronchitis (HP:0002837)3.52036023
33IgM deficiency (HP:0002850)3.49651120
34Abnormality of eosinophils (HP:0001879)3.43135984
35Panhypogammaglobulinemia (HP:0003139)3.41594761
36Chronic diarrhea (HP:0002028)3.39553692
37Combined immunodeficiency (HP:0005387)3.39315386
38Leukocytosis (HP:0001974)3.37585411
39Recurrent viral infections (HP:0004429)3.35440166
40Lymphopenia (HP:0001888)3.35154320
41Spontaneous hematomas (HP:0007420)3.32695478
42Granulocytopenia (HP:0001913)3.22765589
43Recurrent skin infections (HP:0001581)3.20223496
44Abnormality of cells of the lymphoid lineage (HP:0012140)3.19211743
45Keratoconjunctivitis sicca (HP:0001097)3.15873555
46Hypochromic microcytic anemia (HP:0004840)3.09241858
47Chest pain (HP:0100749)3.06233071
48Eosinophilia (HP:0001880)3.02177925
49Joint swelling (HP:0001386)2.96128637
50Keratoconjunctivitis (HP:0001096)2.92256055
51Hypochromic anemia (HP:0001931)2.92096911
52Increased IgE level (HP:0003212)2.91696305
53Hemoptysis (HP:0002105)2.83377952
54Prolonged bleeding time (HP:0003010)2.80990294
55Recurrent gram-negative bacterial infections (HP:0005420)2.72251590
56Inflammation of the large intestine (HP:0002037)2.71896541
57Gastrointestinal inflammation (HP:0004386)2.68835211
58Agammaglobulinemia (HP:0004432)2.66423751
59Pulmonary embolism (HP:0002204)2.64260160
60Hypergammaglobulinemia (HP:0010702)2.63926073
61Epistaxis (HP:0000421)2.62901846
62Thyroiditis (HP:0100646)2.62250727
63Gingivitis (HP:0000230)2.54986600
64Slow saccadic eye movements (HP:0000514)2.54140878
65Urticaria (HP:0001025)2.50368341
66Verrucae (HP:0200043)2.47861033
67Papilloma (HP:0012740)2.47861033
68Hypoplasia of the thymus (HP:0000778)2.47069930
69Papilledema (HP:0001085)2.47044313
70Lymphoma (HP:0002665)2.40824325
71Microcytic anemia (HP:0001935)2.40486628
72Gangrene (HP:0100758)2.40245603
73Acute hepatic failure (HP:0006554)2.38883269
74Abnormality of the prostate (HP:0008775)2.29072815
75Anorexia (HP:0002039)2.24066572
76Petechiae (HP:0000967)2.22438885
77Episodic fever (HP:0001954)2.19780045
78Gingival bleeding (HP:0000225)2.19728412
79Abnormality of the pleura (HP:0002103)2.19288843
80Basal cell carcinoma (HP:0002671)2.10550667
81Abnormality of B cell number (HP:0010975)2.07393528
82Glomerulopathy (HP:0100820)2.06417331
83Sepsis (HP:0100806)2.06012910
84Arterial thrombosis (HP:0004420)2.01127831
85Colitis (HP:0002583)1.99907191
86Ileus (HP:0002595)1.99556434
87Keratitis (HP:0000491)1.96190116
88Aplasia/Hypoplasia of the thymus (HP:0010515)1.95927783
89B lymphocytopenia (HP:0010976)1.95620778
90IgA deficiency (HP:0002720)1.95193784
91Bronchitis (HP:0012387)1.94893452
92Chronic otitis media (HP:0000389)1.93411329
93Recurrent sinusitis (HP:0011108)1.93112766
94Aplastic anemia (HP:0001915)1.92088801
95Cellulitis (HP:0100658)1.91463765
96Autoimmune thrombocytopenia (HP:0001973)1.90578106
97Skin ulcer (HP:0200042)1.90483884
98Nasal polyposis (HP:0100582)1.87572966
99Skin rash (HP:0000988)1.87508838
100Segmental peripheral demyelination/remyelination (HP:0003481)1.86038944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.03463109
2MAP4K15.07778169
3FES3.24758769
4RIPK42.72875409
5ITK2.70639808
6TYK22.52205324
7CSK2.40867911
8ZAP702.34081289
9NLK2.33471578
10SIK32.26699235
11BTK2.25567126
12PASK2.13792799
13GRK62.11238998
14PRPF4B2.08998155
15IKBKE1.97910730
16LCK1.96270404
17JAK31.94495440
18TEC1.78437397
19MAP2K31.76717584
20JAK11.74939735
21TAOK31.72838434
22HCK1.68575760
23SYK1.64130769
24EPHB11.62923815
25MAP3K141.61709348
26IRAK41.61684359
27CAMKK21.59816816
28TAOK11.55693216
29FGFR41.51757426
30TNK21.49265287
31MAP3K131.49127675
32MAP3K111.44563422
33CAMKK11.39173998
34BLK1.31562588
35MAP3K31.29463333
36LYN1.28081660
37TAOK21.26245609
38MARK31.24501324
39MST41.21810629
40STK101.14332564
41FGFR31.14004238
42PRKCQ1.13532446
43TBK11.12730146
44JAK21.11495693
45IKBKB1.07671984
46TYRO31.04836172
47ERN10.95748021
48MAP3K10.94948404
49SIK20.91157079
50CSF1R0.81594255
51LRRK20.78604680
52PDK10.75943994
53EPHA30.72032569
54MAP3K100.70414625
55FYN0.69064087
56PIM10.68574956
57PIK3CG0.67365364
58MAPK110.66222660
59HIPK20.64006841
60MAP3K120.63201659
61MAPK120.59936797
62YES10.58989043
63CLK10.56725756
64FGR0.53237571
65MARK20.51029266
66PDGFRB0.47500147
67CDK40.47171802
68MAP3K50.45983924
69MAP3K70.45508216
70PRKCH0.45121599
71PTK60.44943898
72IRAK10.42236173
73GRK70.42183487
74KIT0.41493949
75MAPKAPK20.40178155
76CDK190.39744164
77STK380.38697107
78TGFBR20.37933014
79NEK60.36413961
80TESK20.34120538
81KSR20.33715382
82SIK10.33440902
83SMG10.31883128
84MAPK70.30301431
85CHUK0.30053510
86PRKD20.28099406
87KDR0.27251877
88MELK0.26351275
89MAP2K60.25856099
90INSR0.25095429
91CDK120.24245349
92IGF1R0.22470696
93DYRK1B0.21746328
94RET0.21740734
95BMPR20.19564442
96NTRK20.19518813
97ALK0.19417882
98BRD40.19372142
99EGFR0.19000465
100PDPK10.17218610

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.72319853
2T cell receptor signaling pathway_Homo sapiens_hsa046603.72869655
3Autoimmune thyroid disease_Homo sapiens_hsa053203.11055446
4Allograft rejection_Homo sapiens_hsa053302.98865424
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.97260239
6Graft-versus-host disease_Homo sapiens_hsa053322.87760316
7Measles_Homo sapiens_hsa051622.74501913
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.48663008
9Osteoclast differentiation_Homo sapiens_hsa043802.43123764
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.22636210
11Type I diabetes mellitus_Homo sapiens_hsa049402.17340301
12Hematopoietic cell lineage_Homo sapiens_hsa046402.09780637
13B cell receptor signaling pathway_Homo sapiens_hsa046622.09048217
14Acute myeloid leukemia_Homo sapiens_hsa052211.99414503
15Antigen processing and presentation_Homo sapiens_hsa046121.99175018
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86238476
17Leishmaniasis_Homo sapiens_hsa051401.81361645
18Viral myocarditis_Homo sapiens_hsa054161.78246718
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.76935452
20Chemokine signaling pathway_Homo sapiens_hsa040621.74435119
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63874534
22Herpes simplex infection_Homo sapiens_hsa051681.62398707
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60567074
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.55315966
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54450958
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52789784
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38015231
28Hepatitis B_Homo sapiens_hsa051611.36013902
29TNF signaling pathway_Homo sapiens_hsa046681.32401935
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29405887
31Malaria_Homo sapiens_hsa051441.28448918
32Toxoplasmosis_Homo sapiens_hsa051451.27832026
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27444977
34Non-small cell lung cancer_Homo sapiens_hsa052231.27370481
35Staphylococcus aureus infection_Homo sapiens_hsa051501.26860965
36Tuberculosis_Homo sapiens_hsa051521.21872355
37Influenza A_Homo sapiens_hsa051641.18872757
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.16191153
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12474360
40Pancreatic cancer_Homo sapiens_hsa052121.07959933
41Viral carcinogenesis_Homo sapiens_hsa052031.06516965
42Epstein-Barr virus infection_Homo sapiens_hsa051691.06466341
43Apoptosis_Homo sapiens_hsa042101.05011911
44Platelet activation_Homo sapiens_hsa046111.03558524
45Shigellosis_Homo sapiens_hsa051311.01160707
46HTLV-I infection_Homo sapiens_hsa051660.98353300
47Colorectal cancer_Homo sapiens_hsa052100.98027402
48VEGF signaling pathway_Homo sapiens_hsa043700.95653533
49Hepatitis C_Homo sapiens_hsa051600.94781941
50Legionellosis_Homo sapiens_hsa051340.91311863
51Regulation of autophagy_Homo sapiens_hsa041400.90431667
52Renal cell carcinoma_Homo sapiens_hsa052110.86694353
53Chronic myeloid leukemia_Homo sapiens_hsa052200.86239134
54Asthma_Homo sapiens_hsa053100.84812456
55Prolactin signaling pathway_Homo sapiens_hsa049170.84475322
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80484143
57African trypanosomiasis_Homo sapiens_hsa051430.78907936
58Endometrial cancer_Homo sapiens_hsa052130.76612967
59FoxO signaling pathway_Homo sapiens_hsa040680.75457145
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74641481
61Thyroid cancer_Homo sapiens_hsa052160.74495694
62Endocytosis_Homo sapiens_hsa041440.73988325
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71156548
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68697801
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.67754243
66Rheumatoid arthritis_Homo sapiens_hsa053230.65561060
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.64875863
68MAPK signaling pathway_Homo sapiens_hsa040100.56126994
69Pertussis_Homo sapiens_hsa051330.53029394
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51638402
71Choline metabolism in cancer_Homo sapiens_hsa052310.49202603
72Prostate cancer_Homo sapiens_hsa052150.48499751
73Salmonella infection_Homo sapiens_hsa051320.47863698
74Inositol phosphate metabolism_Homo sapiens_hsa005620.47505272
75Phagosome_Homo sapiens_hsa041450.44932074
76HIF-1 signaling pathway_Homo sapiens_hsa040660.43182273
77mTOR signaling pathway_Homo sapiens_hsa041500.43064193
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.41570316
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40119958
80Insulin resistance_Homo sapiens_hsa049310.38430222
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38112465
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37681939
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37428398
84Ribosome_Homo sapiens_hsa030100.35997227
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.33285941
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32448647
87Long-term potentiation_Homo sapiens_hsa047200.31725103
88Ras signaling pathway_Homo sapiens_hsa040140.30582316
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30461065
90Notch signaling pathway_Homo sapiens_hsa043300.29722419
91Dorso-ventral axis formation_Homo sapiens_hsa043200.28905111
92ErbB signaling pathway_Homo sapiens_hsa040120.26132595
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.25745676
94Rap1 signaling pathway_Homo sapiens_hsa040150.24465014
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23470201
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21281961
97Proteasome_Homo sapiens_hsa030500.20989622
98Circadian rhythm_Homo sapiens_hsa047100.18877106
99RNA degradation_Homo sapiens_hsa030180.18758736
100Other glycan degradation_Homo sapiens_hsa005110.17762445

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »