TRAV39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)7.29015541
2positive regulation of natural killer cell differentiation (GO:0032825)6.27405971
3intra-S DNA damage checkpoint (GO:0031573)5.95447863
4regulation of activation of Janus kinase activity (GO:0010533)5.88378244
5antigen processing and presentation via MHC class Ib (GO:0002475)5.82951254
6macrophage differentiation (GO:0030225)5.75693410
7positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021105.67117850
8mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)5.67117850
9negative regulation of mast cell activation (GO:0033004)5.45088190
10regulation of RIG-I signaling pathway (GO:0039535)5.36983854
11regulation of transforming growth factor beta2 production (GO:0032909)5.34466807
12positive regulation of histone H3-K4 methylation (GO:0051571)5.33255533
13regulation of B cell receptor signaling pathway (GO:0050855)5.15054609
14positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)5.07128297
15positive regulation of isotype switching (GO:0045830)4.96444802
16negative regulation of phagocytosis (GO:0050765)4.95666677
17positive T cell selection (GO:0043368)4.89935834
18metallo-sulfur cluster assembly (GO:0031163)4.84645953
19iron-sulfur cluster assembly (GO:0016226)4.84645953
20positive regulation of lipoprotein lipase activity (GO:0051006)4.67176500
21positive regulation of triglyceride lipase activity (GO:0061365)4.67176500
22regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.66682208
23spliceosomal tri-snRNP complex assembly (GO:0000244)4.65451813
24response to interferon-beta (GO:0035456)4.57841771
25protein heterotetramerization (GO:0051290)4.47824939
26negative regulation of viral genome replication (GO:0045071)4.46483924
27positive regulation of DNA recombination (GO:0045911)4.45449581
28quinone biosynthetic process (GO:1901663)4.44436692
29negative T cell selection (GO:0043383)4.42309955
30positive regulation of DNA-templated transcription, initiation (GO:2000144)4.41128866
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.40146613
32ubiquinone biosynthetic process (GO:0006744)4.35094822
33regulation of natural killer cell differentiation (GO:0032823)4.34021090
34G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.30647054
35UDP-N-acetylglucosamine metabolic process (GO:0006047)4.27822167
36regulation of chromatin binding (GO:0035561)4.22815616
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.16594168
38positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.12723608
39cellular response to interleukin-15 (GO:0071350)4.04065955
40SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)4.03208312
41positive regulation of triglyceride biosynthetic process (GO:0010867)3.97003456
42pyrimidine nucleotide catabolic process (GO:0006244)3.94798955
43heterotypic cell-cell adhesion (GO:0034113)3.93543742
44positive regulation of mRNA catabolic process (GO:0061014)3.93315565
45T cell selection (GO:0045058)3.83346132
46ubiquinone metabolic process (GO:0006743)3.81125108
47antigen processing and presentation of endogenous antigen (GO:0019883)3.79395751
48positive regulation of mitochondrial membrane permeability (GO:0035794)3.76496089
49positive regulation of transforming growth factor beta production (GO:0071636)3.69891843
50programmed necrotic cell death (GO:0097300)3.63331736
51G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.63205569
52replicative senescence (GO:0090399)3.61009341
53rRNA catabolic process (GO:0016075)3.58537907
54negative regulation of stress fiber assembly (GO:0051497)3.56330869
55negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.54784230
56necroptotic process (GO:0070266)3.54511694
57ribosome assembly (GO:0042255)3.51127235
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48853440
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.46930237
60positive regulation of immunoglobulin production (GO:0002639)3.46899120
61regulation of T cell receptor signaling pathway (GO:0050856)3.44415254
62positive regulation of interferon-alpha production (GO:0032727)3.44025089
63positive regulation of interferon-beta production (GO:0032728)3.42614992
64adipose tissue development (GO:0060612)3.42342975
65positive regulation of natural killer cell mediated immunity (GO:0002717)3.42171362
66positive regulation of gamma-delta T cell activation (GO:0046645)3.38970440
67regulation of cholesterol homeostasis (GO:2000188)3.37561844
68regulation of interferon-alpha production (GO:0032647)3.37405590
69regulation of mRNA catabolic process (GO:0061013)3.34515389
70response to type I interferon (GO:0034340)3.33658485
71type I interferon signaling pathway (GO:0060337)3.33590176
72cellular response to type I interferon (GO:0071357)3.33590176
73T cell costimulation (GO:0031295)3.32250485
74necrotic cell death (GO:0070265)3.31500756
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31065188
76nucleotide-sugar biosynthetic process (GO:0009226)3.30313221
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28432136
78lymphocyte costimulation (GO:0031294)3.27900984
79positive regulation of histone acetylation (GO:0035066)3.26353864
80T cell migration (GO:0072678)3.24896367
81positive thymic T cell selection (GO:0045059)3.24742371
82neuromuscular process controlling posture (GO:0050884)3.21507099
83negative regulation of glycoprotein biosynthetic process (GO:0010561)3.20763235
84detection of bacterium (GO:0016045)3.19042442
85response to interleukin-15 (GO:0070672)3.18095763
86negative regulation of B cell proliferation (GO:0030889)3.17761909
87regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17505036
88isoprenoid biosynthetic process (GO:0008299)3.16656767
89regulation of viral genome replication (GO:0045069)3.16220599
90regulation of metalloenzyme activity (GO:0048552)3.12348528
91T cell receptor signaling pathway (GO:0050852)3.08617859
92regulation of natural killer cell mediated immunity (GO:0002715)3.06532148
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.06532148
94regulation of isotype switching (GO:0045191)3.04353719
95cellular response to zinc ion (GO:0071294)3.03141073
96regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.02583590
97protein localization to cell surface (GO:0034394)3.00265034
98negative regulation of actin filament bundle assembly (GO:0032232)2.99337461
99peptidyl-arginine omega-N-methylation (GO:0035247)2.98962451
100negative regulation of viral entry into host cell (GO:0046597)2.97956294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.84576037
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.31875746
3GATA1_22025678_ChIP-Seq_K562_Human4.87906068
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.32767857
5SMAD_19615063_ChIP-ChIP_OVARY_Human4.32139085
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.17519421
7MYB_26560356_Chip-Seq_TH2_Human2.91510552
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.86013271
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79606695
10RUNX_20019798_ChIP-Seq_JUKART_Human2.68753850
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61113288
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39553010
13MYB_26560356_Chip-Seq_TH1_Human2.28770889
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28493150
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11940303
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08274499
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06343251
18GATA3_26560356_Chip-Seq_TH2_Human1.99542199
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92327611
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.77032733
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74308769
22EZH2_22144423_ChIP-Seq_EOC_Human1.73783293
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72945697
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71426366
25GATA3_27048872_Chip-Seq_THYMUS_Human1.67099643
26UTX_26944678_Chip-Seq_JUKART_Human1.65342924
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64454090
28VDR_23849224_ChIP-Seq_CD4+_Human1.61924068
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61503364
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.61080172
31MAF_26560356_Chip-Seq_TH2_Human1.52420122
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51932980
33AR_20517297_ChIP-Seq_VCAP_Human1.51281546
34SPI1_23547873_ChIP-Seq_NB4_Human1.44045084
35MAF_26560356_Chip-Seq_TH1_Human1.44027596
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39590394
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39566185
38GBX2_23144817_ChIP-Seq_PC3_Human1.39442809
39NANOG_20526341_ChIP-Seq_ESCs_Human1.38622355
40ELK1_19687146_ChIP-ChIP_HELA_Human1.37239353
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35971227
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30501425
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26165522
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20539105
45NCOR_22424771_ChIP-Seq_293T_Human1.17574292
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.17539625
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16403299
48DROSHA_22980978_ChIP-Seq_HELA_Human1.16323355
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10746074
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07560119
51SPI1_23127762_ChIP-Seq_K562_Human1.07389128
52STAT1_20625510_ChIP-Seq_HELA_Human1.06380554
53TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06097453
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05756463
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05483579
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.05314127
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.05049751
58P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04087641
59RAC3_21632823_ChIP-Seq_H3396_Human1.02618508
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00445753
61ERA_21632823_ChIP-Seq_H3396_Human1.00285730
62BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.99874506
63BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99546718
64CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98412969
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97894161
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97536673
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97388944
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93970085
69SRF_21415370_ChIP-Seq_HL-1_Mouse0.92686543
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91800533
71BCOR_27268052_Chip-Seq_Bcells_Human0.89521886
72HOXB7_26014856_ChIP-Seq_BT474_Human0.87925002
73CTCF_18555785_Chip-Seq_ESCs_Mouse0.86458915
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85389192
75STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84770782
76CBP_20019798_ChIP-Seq_JUKART_Human0.84314938
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84314938
78GATA1_19941826_ChIP-Seq_K562_Human0.83410933
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83017493
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82087153
81RUNX1_22412390_ChIP-Seq_EML_Mouse0.81949158
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81573141
83GATA1_26923725_Chip-Seq_HPCs_Mouse0.80079827
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79102282
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79046531
86SUZ12_18555785_Chip-Seq_ESCs_Mouse0.78971006
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.78273898
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78183758
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78147511
90LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.78035810
91GATA3_26560356_Chip-Seq_TH1_Human0.77430193
92RUNX1_27457419_Chip-Seq_LIVER_Mouse0.76227049
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.75257814
94EGR1_19032775_ChIP-ChIP_M12_Human0.74552116
95VDR_22108803_ChIP-Seq_LS180_Human0.74292347
96OCT4_18555785_Chip-Seq_ESCs_Mouse0.74080195
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.73896795
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73896795
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.73242647
100BCAT_22108803_ChIP-Seq_LS180_Human0.72534721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.89847463
2MP0003763_abnormal_thymus_physiology5.59468406
3MP0005671_abnormal_response_to5.58705810
4MP0002653_abnormal_ependyma_morphology4.03775962
5MP0000685_abnormal_immune_system3.49445496
6MP0009840_abnormal_foam_cell2.99962881
7MP0003191_abnormal_cellular_cholesterol2.98715228
8MP0009785_altered_susceptibility_to2.96281389
9MP0005387_immune_system_phenotype2.88078651
10MP0001790_abnormal_immune_system2.88078651
11MP0001835_abnormal_antigen_presentation2.85576774
12MP0004147_increased_porphyrin_level2.70420388
13MP0009278_abnormal_bone_marrow2.67552622
14MP0000858_altered_metastatic_potential2.61416588
15MP0003880_abnormal_central_pattern2.60855904
16MP0005025_abnormal_response_to2.43264689
17MP0005451_abnormal_body_composition2.32314797
18MP0001800_abnormal_humoral_immune2.22106673
19MP0002723_abnormal_immune_serum1.99988680
20MP0002638_abnormal_pupillary_reflex1.94617380
21MP0004134_abnormal_chest_morphology1.89646033
22MP0004885_abnormal_endolymph1.87836642
23MP0002420_abnormal_adaptive_immunity1.85016342
24MP0001819_abnormal_immune_cell1.80773164
25MP0003436_decreased_susceptibility_to1.69171432
26MP0004130_abnormal_muscle_cell1.60213843
27MP0005503_abnormal_tendon_morphology1.59404031
28MP0001851_eye_inflammation1.58003857
29MP0005000_abnormal_immune_tolerance1.57587756
30MP0002452_abnormal_antigen_presenting1.57236547
31MP0001533_abnormal_skeleton_physiology1.56512223
32MP0002398_abnormal_bone_marrow1.48908825
33MP0010155_abnormal_intestine_physiology1.47833890
34MP0002166_altered_tumor_susceptibility1.46778125
35MP0000716_abnormal_immune_system1.45814387
36MP0003693_abnormal_embryo_hatching1.43853324
37MP0001873_stomach_inflammation1.42986894
38MP0002148_abnormal_hypersensitivity_rea1.38522130
39MP0009379_abnormal_foot_pigmentation1.27890656
40MP0005076_abnormal_cell_differentiation1.25213636
41MP0002006_tumorigenesis1.23955829
42MP0009333_abnormal_splenocyte_physiolog1.22612148
43MP0000703_abnormal_thymus_morphology1.21882673
44MP0001845_abnormal_inflammatory_respons1.20925571
45MP0003866_abnormal_defecation1.19764271
46MP0002722_abnormal_immune_system1.19174889
47MP0003303_peritoneal_inflammation1.18014439
48MP0002419_abnormal_innate_immunity1.16734140
49MP0002098_abnormal_vibrissa_morphology1.11456442
50MP0009115_abnormal_fat_cell1.07898473
51MP0002429_abnormal_blood_cell1.05484675
52MP0003329_amyloid_beta_deposits1.04216431
53MP0002405_respiratory_system_inflammati1.02317240
54MP0000689_abnormal_spleen_morphology1.01330888
55MP0008469_abnormal_protein_level0.98063240
56MP0002095_abnormal_skin_pigmentation0.95990110
57MP0010386_abnormal_urinary_bladder0.85283520
58MP0002693_abnormal_pancreas_physiology0.84818600
59MP0005408_hypopigmentation0.79659423
60MP0001963_abnormal_hearing_physiology0.73647460
61MP0008961_abnormal_basal_metabolism0.72901059
62MP0003638_abnormal_response/metabolism_0.72887250
63MP0009763_increased_sensitivity_to0.72229194
64MP0000604_amyloidosis0.71038132
65MP0002138_abnormal_hepatobiliary_system0.69037054
66MP0008569_lethality_at_weaning0.68220355
67MP0005390_skeleton_phenotype0.64633686
68MP0001663_abnormal_digestive_system0.64109274
69MP0009643_abnormal_urine_homeostasis0.60843622
70MP0002168_other_aberrant_phenotype0.60492002
71MP0002019_abnormal_tumor_incidence0.60391596
72MP0005397_hematopoietic_system_phenotyp0.59702903
73MP0001545_abnormal_hematopoietic_system0.59702903
74MP0001270_distended_abdomen0.59156364
75MP0008058_abnormal_DNA_repair0.56951229
76MP0003646_muscle_fatigue0.56918971
77MP0005319_abnormal_enzyme/_coenzyme0.55453008
78MP0002933_joint_inflammation0.55051392
79MP0005266_abnormal_metabolism0.54338643
80MP0001853_heart_inflammation0.53673875
81MP0001119_abnormal_female_reproductive0.53294107
82MP0005410_abnormal_fertilization0.51295183
83MP0001666_abnormal_nutrient_absorption0.50036016
84MP0001919_abnormal_reproductive_system0.49220222
85MP0001765_abnormal_ion_homeostasis0.48723629
86MP0001243_abnormal_dermal_layer0.48157867
87MP0002078_abnormal_glucose_homeostasis0.47805089
88MP0000749_muscle_degeneration0.47252235
89MP0000427_abnormal_hair_cycle0.46029083
90MP0009764_decreased_sensitivity_to0.45997771
91MP0001905_abnormal_dopamine_level0.43831401
92MP0005645_abnormal_hypothalamus_physiol0.43757333
93MP0002127_abnormal_cardiovascular_syste0.43230409
94MP0004381_abnormal_hair_follicle0.42344920
95MP0000026_abnormal_inner_ear0.41805639
96MP0003172_abnormal_lysosome_physiology0.39912968
97MP0004947_skin_inflammation0.39138324
98MP0001727_abnormal_embryo_implantation0.38681786
99MP0004142_abnormal_muscle_tone0.38303910
100MP0002136_abnormal_kidney_physiology0.37911490

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)4.70260892
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.40578742
3Abnormality of T cell number (HP:0011839)4.26075104
4T lymphocytopenia (HP:0005403)4.25540083
5Hypoproteinemia (HP:0003075)4.10617814
6Aortic regurgitation (HP:0001659)4.10614416
7Stomatitis (HP:0010280)3.99943103
8Retrobulbar optic neuritis (HP:0100654)3.89225693
9Optic neuritis (HP:0100653)3.89225693
10IgG deficiency (HP:0004315)3.75301343
11Hyperactive renin-angiotensin system (HP:0000841)3.63878766
12Orchitis (HP:0100796)3.58456183
13Dyschromatopsia (HP:0007641)3.58282744
14Myositis (HP:0100614)3.43004382
15Hypokalemic alkalosis (HP:0001949)3.41923149
16Fatigable weakness (HP:0003473)3.33239366
17Abnormality of the neuromuscular junction (HP:0003398)3.33239366
18Depressed nasal tip (HP:0000437)3.30978166
19Metaphyseal dysplasia (HP:0100255)3.30818012
20Increased IgM level (HP:0003496)3.20693753
21Elevated erythrocyte sedimentation rate (HP:0003565)3.19744994
22Hyponatremia (HP:0002902)3.19151494
23Anorexia (HP:0002039)3.16370250
24Hyperaldosteronism (HP:0000859)3.13615975
25Severe combined immunodeficiency (HP:0004430)3.03986144
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.01223041
27Progressive inability to walk (HP:0002505)2.86440290
28Severe muscular hypotonia (HP:0006829)2.84581536
29Recurrent cutaneous fungal infections (HP:0011370)2.79787817
30Chronic mucocutaneous candidiasis (HP:0002728)2.79787817
31Birth length less than 3rd percentile (HP:0003561)2.73585249
32Easy fatigability (HP:0003388)2.72472861
33Autoimmune hemolytic anemia (HP:0001890)2.70517110
34Agammaglobulinemia (HP:0004432)2.67163630
35Recurrent bronchitis (HP:0002837)2.64512608
36Mitral regurgitation (HP:0001653)2.62750577
37Neonatal respiratory distress (HP:0002643)2.59676862
38Abnormality of renin-angiotensin system (HP:0000847)2.58514249
39Cerebellar dysplasia (HP:0007033)2.56499856
40Bronchitis (HP:0012387)2.56421545
41Ileus (HP:0002595)2.53757739
42Enlarged epiphyses (HP:0010580)2.52197346
43Thyroiditis (HP:0100646)2.51947025
44Abnormality of sodium homeostasis (HP:0010931)2.49434395
45Abnormality of T cells (HP:0002843)2.49351374
46Chronic diarrhea (HP:0002028)2.49201695
47Inability to walk (HP:0002540)2.48586021
48Pustule (HP:0200039)2.48441229
49Keratoconjunctivitis sicca (HP:0001097)2.48176774
50Anterior segment dysgenesis (HP:0007700)2.44944108
51Abnormality of eosinophils (HP:0001879)2.44668324
52Chronic bronchitis (HP:0004469)2.44652727
53Polyneuropathy (HP:0001271)2.43419027
54Renal salt wasting (HP:0000127)2.41322383
55Type II lissencephaly (HP:0007260)2.40877221
56Hypochromic anemia (HP:0001931)2.39530414
57Vacuolated lymphocytes (HP:0001922)2.33519123
58Proximal amyotrophy (HP:0007126)2.29918485
593-Methylglutaconic aciduria (HP:0003535)2.27825975
60True hermaphroditism (HP:0010459)2.26360768
61Keratoconjunctivitis (HP:0001096)2.26347383
62Vasculitis (HP:0002633)2.25930126
63Combined immunodeficiency (HP:0005387)2.24292389
64Hypoplasia of the thymus (HP:0000778)2.23992462
65Cerebral hypomyelination (HP:0006808)2.23473929
66Limb hypertonia (HP:0002509)2.22572959
67Unsteady gait (HP:0002317)2.21385548
68Recurrent fungal infections (HP:0002841)2.19189636
69Pancreatic cysts (HP:0001737)2.16271339
70Pulmonary infiltrates (HP:0002113)2.16157518
71Abnormality of the umbilical cord (HP:0010881)2.15749955
72Hypoalbuminemia (HP:0003073)2.14361562
73Abnormal albumin level (HP:0012116)2.14361562
74Fair hair (HP:0002286)2.11702561
75Mildly elevated creatine phosphokinase (HP:0008180)2.09072456
76Joint swelling (HP:0001386)2.08834783
77Cutis marmorata (HP:0000965)2.07446899
78Alkalosis (HP:0001948)2.07360504
79Rectal prolapse (HP:0002035)2.06467056
80Abnormality of the pleura (HP:0002103)2.05697558
81Lymphopenia (HP:0001888)2.05605477
82Increased hepatocellular lipid droplets (HP:0006565)2.04345759
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.03608003
84Aplasia/Hypoplasia of the fovea (HP:0008060)2.01966966
85Hypoplasia of the fovea (HP:0007750)2.01966966
86Pancreatic fibrosis (HP:0100732)1.99172228
87Constricted visual fields (HP:0001133)1.99132564
88Exotropia (HP:0000577)1.99072736
89Bulbar palsy (HP:0001283)1.95745489
90Episodic fever (HP:0001954)1.94301126
91Abnormality of the nasal septum (HP:0000419)1.90741262
92Increased serum lactate (HP:0002151)1.90278102
93Diaphragmatic weakness (HP:0009113)1.89348991
94Decreased subcutaneous fat (HP:0001002)1.87975609
95Leukocytosis (HP:0001974)1.87727270
96Hemoptysis (HP:0002105)1.84404349
9711 pairs of ribs (HP:0000878)1.83938126
98Focal motor seizures (HP:0011153)1.82640235
99Cellular immunodeficiency (HP:0005374)1.82267167
100Macular degeneration (HP:0000608)1.78278474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK8.34040115
2RIPK15.64431905
3VRK14.74430536
4TXK4.26403061
5CDK82.90095913
6BTK2.66870079
7TGFBR22.61791839
8FES2.59826583
9VRK22.43272997
10PRPF4B2.31467847
11TYRO32.25147964
12MAP4K12.20198764
13CSK1.95464848
14KDR1.81217645
15IRAK31.70020447
16HCK1.68160860
17TAOK31.66575219
18PIK3CA1.63357045
19TLK11.47155193
20ZAK1.40712564
21NLK1.39924491
22SYK1.34077740
23JAK31.33698815
24TRPM71.25973545
25ADRBK21.16128644
26MAP2K61.15118806
27ITK1.13177234
28IKBKE1.08568228
29TNIK1.02892327
30JAK11.01455146
31LCK1.00626720
32TYK20.92475874
33PLK30.90384728
34TBK10.90291350
35PDGFRB0.89522231
36TEC0.89377129
37MAPK70.88760464
38SIK30.85512541
39PKN20.84374084
40PRKD30.81824690
41PIK3CG0.80177127
42LYN0.78933137
43TRIM280.78598387
44PIM10.76447965
45ZAP700.76044230
46KIT0.75358265
47FGFR40.72183106
48FGFR30.67011583
49MAPKAPK20.64201391
50PDK10.59122988
51BUB10.58637086
52GRK10.54213465
53PDK20.52375988
54CLK10.52124696
55GRK70.51913434
56PTK2B0.49482336
57PRKCE0.47947754
58TESK20.46311766
59IGF1R0.44976227
60CDK190.40984249
61FRK0.39118042
62BCKDK0.39001136
63MAPK130.37631942
64JAK20.36715645
65STK100.36233110
66RPS6KA50.35324977
67ADRBK10.34317524
68LRRK20.34312032
69PRKCQ0.34198386
70FYN0.31820977
71IRAK10.31209820
72IKBKB0.29552067
73CHEK20.28519597
74PRKCH0.28377053
75PHKG10.28278649
76PHKG20.28278649
77PASK0.27297347
78MAPK110.27295332
79GRK60.26067158
80TNK20.24434903
81MAPK90.24025220
82MAPKAPK30.22567838
83CDK30.21822199
84PDPK10.21292584
85HIPK20.20948428
86INSRR0.20599538
87PRKCB0.18938349
88PRKACG0.17994067
89PRKACA0.17272176
90PRKCG0.16505950
91MAPK120.14383574
92ACVR1B0.14286361
93NEK20.14218820
94DYRK1A0.14163030
95RET0.13972850
96PRKCA0.13750726
97MYLK0.12759746
98RPS6KB10.12401925
99INSR0.11857277
100CDK40.11244238

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.43821339
2T cell receptor signaling pathway_Homo sapiens_hsa046603.20064079
3Basal transcription factors_Homo sapiens_hsa030223.03006777
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.87516093
5One carbon pool by folate_Homo sapiens_hsa006702.86648149
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.43876877
7Malaria_Homo sapiens_hsa051442.42060227
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36297770
9Hematopoietic cell lineage_Homo sapiens_hsa046402.33634459
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19250748
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.16082364
12Antigen processing and presentation_Homo sapiens_hsa046122.06462891
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01900195
14Selenocompound metabolism_Homo sapiens_hsa004501.95262008
15Measles_Homo sapiens_hsa051621.91613140
16Graft-versus-host disease_Homo sapiens_hsa053321.73107055
17Proteasome_Homo sapiens_hsa030501.64514826
18Ribosome_Homo sapiens_hsa030101.58559336
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.58497534
20Homologous recombination_Homo sapiens_hsa034401.57779723
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.56960671
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.54812541
23Hepatitis B_Homo sapiens_hsa051611.53438146
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46444560
25HTLV-I infection_Homo sapiens_hsa051661.39972085
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39576103
27Mismatch repair_Homo sapiens_hsa034301.39425582
28Osteoclast differentiation_Homo sapiens_hsa043801.28334764
29TNF signaling pathway_Homo sapiens_hsa046681.26361448
30Herpes simplex infection_Homo sapiens_hsa051681.21801695
31Autoimmune thyroid disease_Homo sapiens_hsa053201.19317431
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17000318
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.16118578
34Nucleotide excision repair_Homo sapiens_hsa034201.15985007
35Oxidative phosphorylation_Homo sapiens_hsa001901.13470529
36Viral carcinogenesis_Homo sapiens_hsa052031.12136996
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08848075
38Dorso-ventral axis formation_Homo sapiens_hsa043201.06068604
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03280528
40Allograft rejection_Homo sapiens_hsa053300.99419475
41Influenza A_Homo sapiens_hsa051640.89593448
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87050426
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85645973
44B cell receptor signaling pathway_Homo sapiens_hsa046620.84896741
45Tryptophan metabolism_Homo sapiens_hsa003800.84313897
46Nitrogen metabolism_Homo sapiens_hsa009100.81346497
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81217496
48Cocaine addiction_Homo sapiens_hsa050300.80987741
49Platelet activation_Homo sapiens_hsa046110.80884020
50Viral myocarditis_Homo sapiens_hsa054160.80140963
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78176313
52N-Glycan biosynthesis_Homo sapiens_hsa005100.77999595
53Shigellosis_Homo sapiens_hsa051310.75525433
54Insulin resistance_Homo sapiens_hsa049310.75393928
55Sulfur metabolism_Homo sapiens_hsa009200.74627019
56Epstein-Barr virus infection_Homo sapiens_hsa051690.74053992
57Butanoate metabolism_Homo sapiens_hsa006500.73460669
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73244239
59RNA degradation_Homo sapiens_hsa030180.69847909
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66495523
61Folate biosynthesis_Homo sapiens_hsa007900.66379394
62African trypanosomiasis_Homo sapiens_hsa051430.64723351
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62846524
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.60442040
65ABC transporters_Homo sapiens_hsa020100.59724582
66Glycerolipid metabolism_Homo sapiens_hsa005610.59219948
67Linoleic acid metabolism_Homo sapiens_hsa005910.56185867
68Parkinsons disease_Homo sapiens_hsa050120.56004698
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55408120
70Leishmaniasis_Homo sapiens_hsa051400.54904275
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54736178
72Chemokine signaling pathway_Homo sapiens_hsa040620.52248017
73Amphetamine addiction_Homo sapiens_hsa050310.51212264
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48155306
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46576368
76Tuberculosis_Homo sapiens_hsa051520.45745265
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45514457
78Hepatitis C_Homo sapiens_hsa051600.45282044
79Staphylococcus aureus infection_Homo sapiens_hsa051500.44242515
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42655377
81Rheumatoid arthritis_Homo sapiens_hsa053230.42325536
82Sulfur relay system_Homo sapiens_hsa041220.42180723
83Huntingtons disease_Homo sapiens_hsa050160.41015690
84Renal cell carcinoma_Homo sapiens_hsa052110.40318027
85Colorectal cancer_Homo sapiens_hsa052100.39628644
86Toxoplasmosis_Homo sapiens_hsa051450.38394066
87Pancreatic cancer_Homo sapiens_hsa052120.38118374
88Pertussis_Homo sapiens_hsa051330.37718631
89Cardiac muscle contraction_Homo sapiens_hsa042600.36290524
90Phototransduction_Homo sapiens_hsa047440.36063742
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35306895
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.31602258
93Regulation of autophagy_Homo sapiens_hsa041400.31515539
94Asthma_Homo sapiens_hsa053100.30571185
95Basal cell carcinoma_Homo sapiens_hsa052170.30460544
96Type I diabetes mellitus_Homo sapiens_hsa049400.29298976
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.27818548
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27448974
99MAPK signaling pathway_Homo sapiens_hsa040100.27428005
100Olfactory transduction_Homo sapiens_hsa047400.25734048

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