TRAV4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.67686317
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.73231484
3regulation of T cell tolerance induction (GO:0002664)6.52113552
4negative thymic T cell selection (GO:0045060)6.50317035
5positive regulation of tolerance induction (GO:0002645)6.24807632
6positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.18108161
7pyrimidine ribonucleoside catabolic process (GO:0046133)6.17564249
8positive regulation of natural killer cell mediated immunity (GO:0002717)6.13325803
9regulation of regulatory T cell differentiation (GO:0045589)5.99314649
10regulation of T cell chemotaxis (GO:0010819)5.98527274
11positive regulation of T cell chemotaxis (GO:0010820)5.98527274
12cellular response to interleukin-15 (GO:0071350)5.93583430
13cytidine metabolic process (GO:0046087)5.72191049
14cytidine catabolic process (GO:0006216)5.72191049
15cytidine deamination (GO:0009972)5.72191049
16regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.44852778
17regulation of natural killer cell mediated immunity (GO:0002715)5.44852778
18thymic T cell selection (GO:0045061)5.42623385
19regulation of tolerance induction (GO:0002643)5.36319034
20positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.29889764
21positive T cell selection (GO:0043368)5.26793966
22regulation of activation of Janus kinase activity (GO:0010533)5.23503642
23activated T cell proliferation (GO:0050798)5.23384151
24positive regulation of gamma-delta T cell activation (GO:0046645)5.17129120
25T cell selection (GO:0045058)5.01599065
26response to interleukin-15 (GO:0070672)4.97252510
27positive regulation of alpha-beta T cell proliferation (GO:0046641)4.92791758
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91072442
29regulation of alpha-beta T cell proliferation (GO:0046640)4.79790668
30regulation of leukocyte mediated cytotoxicity (GO:0001910)4.67041679
31positive regulation of cell killing (GO:0031343)4.65800407
32regulation of chronic inflammatory response (GO:0002676)4.62740300
33regulation of T cell receptor signaling pathway (GO:0050856)4.61976567
34regulation of B cell receptor signaling pathway (GO:0050855)4.50939958
35DNA deamination (GO:0045006)4.49675566
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.47810113
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.46277967
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.43664250
39positive thymic T cell selection (GO:0045059)4.39753329
40regulation of lymphocyte chemotaxis (GO:1901623)4.37944352
41regulation of isotype switching to IgG isotypes (GO:0048302)4.37029670
42positive regulation of T cell mediated cytotoxicity (GO:0001916)4.25683278
43T cell receptor signaling pathway (GO:0050852)4.20110263
44regulation of cell killing (GO:0031341)4.16844896
45interferon-gamma production (GO:0032609)4.05099899
46cellular defense response (GO:0006968)4.03712066
47Arp2/3 complex-mediated actin nucleation (GO:0034314)4.01788812
48regulation of gamma-delta T cell activation (GO:0046643)3.96237903
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.94795624
50regulation of gamma-delta T cell differentiation (GO:0045586)3.94329913
51positive regulation of calcium-mediated signaling (GO:0050850)3.90426332
52negative regulation of T cell mediated immunity (GO:0002710)3.88603573
53T cell costimulation (GO:0031295)3.84211337
54T cell mediated immunity (GO:0002456)3.83923214
55T cell migration (GO:0072678)3.81711351
56lymphocyte costimulation (GO:0031294)3.81229253
57regulation of T cell mediated cytotoxicity (GO:0001914)3.77311054
58positive regulation of T cell migration (GO:2000406)3.76471608
59positive regulation of humoral immune response (GO:0002922)3.68061212
60lymphocyte chemotaxis (GO:0048247)3.66624607
61actin nucleation (GO:0045010)3.65193056
62antigen receptor-mediated signaling pathway (GO:0050851)3.58984962
63signal complex assembly (GO:0007172)3.58303265
64positive regulation of lymphocyte migration (GO:2000403)3.58010988
65regulation of macrophage chemotaxis (GO:0010758)3.55696710
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53742567
67negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.53181788
68negative regulation of cell killing (GO:0031342)3.52570057
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52570057
70regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.51979007
71positive regulation of lymphocyte mediated immunity (GO:0002708)3.48838660
72regulation of interleukin-12 biosynthetic process (GO:0045075)3.47285272
73dendritic cell chemotaxis (GO:0002407)3.43014003
74positive regulation of interleukin-4 production (GO:0032753)3.40688292
75regulation of immune response to tumor cell (GO:0002837)3.38540920
76regulation of response to tumor cell (GO:0002834)3.38540920
77positive regulation of response to tumor cell (GO:0002836)3.38540920
78positive regulation of immune response to tumor cell (GO:0002839)3.38540920
79negative regulation of interleukin-12 production (GO:0032695)3.38014668
80negative regulation of viral genome replication (GO:0045071)3.34552196
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33933329
82chemokine-mediated signaling pathway (GO:0070098)3.30051110
83positive regulation of granulocyte differentiation (GO:0030854)3.28874943
84lymphocyte migration (GO:0072676)3.27210422
85positive regulation of interleukin-17 production (GO:0032740)3.25719008
86negative regulation of T cell apoptotic process (GO:0070233)3.25517930
87regulation of T cell migration (GO:2000404)3.25304800
88leukocyte aggregation (GO:0070486)3.24199291
89T cell apoptotic process (GO:0070231)3.17137718
90antigen processing and presentation of endogenous antigen (GO:0019883)3.09880384
91positive regulation of natural killer cell differentiation (GO:0032825)3.06321818
92positive regulation of leukocyte mediated immunity (GO:0002705)3.05017073
93NIK/NF-kappaB signaling (GO:0038061)3.04480071
94positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.03717957
95negative regulation of B cell activation (GO:0050869)3.01148651
96regulation of mononuclear cell migration (GO:0071675)3.01095469
97T cell proliferation (GO:0042098)3.00950037
98negative regulation of T cell receptor signaling pathway (GO:0050860)3.00771522
99antigen processing and presentation via MHC class Ib (GO:0002475)3.00048625
100eosinophil chemotaxis (GO:0048245)2.96657997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.50596079
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.37633058
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.74943242
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.30811054
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.29308902
6RUNX_20019798_ChIP-Seq_JUKART_Human3.54735126
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.29301504
8MYB_26560356_Chip-Seq_TH2_Human3.27312040
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23248699
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.11580668
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.11134583
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.96627431
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.84704666
14VDR_22108803_ChIP-Seq_LS180_Human2.56732097
15MYB_26560356_Chip-Seq_TH1_Human2.33286677
16GATA3_27048872_Chip-Seq_THYMUS_Human2.26278952
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24297232
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21236893
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.11532386
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08727526
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05625638
22GATA3_26560356_Chip-Seq_TH2_Human1.98890328
23UTX_26944678_Chip-Seq_JUKART_Human1.93109985
24MAF_26560356_Chip-Seq_TH1_Human1.81782252
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76533176
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70288333
27MAF_26560356_Chip-Seq_TH2_Human1.65216405
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64025094
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63982228
30VDR_23849224_ChIP-Seq_CD4+_Human1.63276944
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62108744
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57664672
33FOXP3_21729870_ChIP-Seq_TREG_Human1.54735885
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46152822
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.44418981
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.43101452
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.41200102
38SPI1_23547873_ChIP-Seq_NB4_Human1.40067940
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35594158
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33525134
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.27863288
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27054519
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24473446
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20379718
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16361870
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15617425
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14113336
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14047355
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07043176
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05217136
51TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01149230
52PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98162483
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96435647
54IGF1R_20145208_ChIP-Seq_DFB_Human0.93435833
55NFE2_27457419_Chip-Seq_LIVER_Mouse0.93349229
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91635161
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90492674
58EST1_17652178_ChIP-ChIP_JURKAT_Human0.89154644
59FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87760319
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86952839
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86567311
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86128291
63BCL6_27268052_Chip-Seq_Bcells_Human0.85806896
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85531942
65PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84876013
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84317925
67GATA3_26560356_Chip-Seq_TH1_Human0.84294874
68SPI1_23127762_ChIP-Seq_K562_Human0.83814754
69YY1_22570637_ChIP-Seq_MALME-3M_Human0.83259042
70EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82846201
71RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82374438
72P300_27268052_Chip-Seq_Bcells_Human0.77805884
73NANOG_20526341_ChIP-Seq_ESCs_Human0.77310907
74CTCF_20526341_ChIP-Seq_ESCs_Human0.74814062
75EZH2_27294783_Chip-Seq_NPCs_Mouse0.74608108
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.73900399
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.73868495
78TAF2_19829295_ChIP-Seq_ESCs_Human0.73692641
79BRD4_27068464_Chip-Seq_AML-cells_Mouse0.73249649
80SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72961635
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72872321
82BCAT_22108803_ChIP-Seq_LS180_Human0.72270145
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.72209378
84MYB_21317192_ChIP-Seq_ERMYB_Mouse0.68456841
85OCT4_20526341_ChIP-Seq_ESCs_Human0.67443558
86ER_23166858_ChIP-Seq_MCF-7_Human0.67301051
87RAC3_21632823_ChIP-Seq_H3396_Human0.66924154
88EGR1_19032775_ChIP-ChIP_M12_Human0.66887834
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.65690203
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.64836420
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.64296600
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.64191549
93SPI1_20517297_ChIP-Seq_HL60_Human0.63350094
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.62955546
95ERA_21632823_ChIP-Seq_H3396_Human0.62774702
96RUNX1_22412390_ChIP-Seq_EML_Mouse0.62595494
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.62481772
98CEBPB_22108803_ChIP-Seq_LS180_Human0.61773032
99SMRT_27268052_Chip-Seq_Bcells_Human0.61354370
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.60911846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.12418433
2MP0003763_abnormal_thymus_physiology3.80054373
3MP0009333_abnormal_splenocyte_physiolog3.42861617
4MP0009785_altered_susceptibility_to3.38038927
5MP0001835_abnormal_antigen_presentation3.37672338
6MP0005000_abnormal_immune_tolerance3.26048559
7MP0002163_abnormal_gland_morphology3.24546899
8MP0000685_abnormal_immune_system3.09143760
9MP0001800_abnormal_humoral_immune2.99225228
10MP0005387_immune_system_phenotype2.77532037
11MP0001790_abnormal_immune_system2.77532037
12MP0002723_abnormal_immune_serum2.76884968
13MP0002420_abnormal_adaptive_immunity2.74020267
14MP0002148_abnormal_hypersensitivity_rea2.71233039
15MP0001819_abnormal_immune_cell2.68860548
16MP0005025_abnormal_response_to2.58231747
17MP0001348_abnormal_lacrimal_gland2.52518876
18MP0005310_abnormal_salivary_gland2.47873532
19MP0003866_abnormal_defecation2.39526292
20MP0002006_tumorigenesis2.39362695
21MP0002166_altered_tumor_susceptibility2.37572727
22MP0003436_decreased_susceptibility_to2.37359884
23MP0002452_abnormal_antigen_presenting2.34157963
24MP0001873_stomach_inflammation2.33197382
25MP0002398_abnormal_bone_marrow2.32438788
26MP0005451_abnormal_body_composition2.32415628
27MP0006082_CNS_inflammation2.30418677
28MP0000716_abnormal_immune_system2.03877275
29MP0001346_abnormal_lacrimal_gland1.96142219
30MP0005379_endocrine/exocrine_gland_phen1.94901838
31MP0010155_abnormal_intestine_physiology1.94309789
32MP0002419_abnormal_innate_immunity1.94121851
33MP0000703_abnormal_thymus_morphology1.93067304
34MP0002405_respiratory_system_inflammati1.91106561
35MP0004381_abnormal_hair_follicle1.90841350
36MP0001845_abnormal_inflammatory_respons1.76612365
37MP0000689_abnormal_spleen_morphology1.75401438
38MP0004947_skin_inflammation1.70956738
39MP0002722_abnormal_immune_system1.66886540
40MP0003045_fibrosis1.61903648
41MP0002429_abnormal_blood_cell1.59498661
42MP0002277_abnormal_respiratory_mucosa1.55260019
43MP0002102_abnormal_ear_morphology1.49561326
44MP0003448_altered_tumor_morphology1.39995923
45MP0001853_heart_inflammation1.38566221
46MP0003300_gastrointestinal_ulcer1.37592510
47MP0003646_muscle_fatigue1.36580794
48MP0002876_abnormal_thyroid_physiology1.31403785
49MP0008872_abnormal_physiological_respon1.30512082
50MP0005075_abnormal_melanosome_morpholog1.28190052
51MP0002933_joint_inflammation1.23013713
52MP0008469_abnormal_protein_level1.19428611
53MP0000465_gastrointestinal_hemorrhage1.16238069
54MP0002822_catalepsy1.16132128
55MP0003786_premature_aging1.14944160
56MP0000372_irregular_coat_pigmentation1.11902918
57MP0003724_increased_susceptibility_to1.09263610
58MP0002693_abnormal_pancreas_physiology1.09020192
59MP0009763_increased_sensitivity_to1.04245835
60MP0009764_decreased_sensitivity_to0.98563367
61MP0002009_preneoplasia0.97762616
62MP0008961_abnormal_basal_metabolism0.97525366
63MP0001533_abnormal_skeleton_physiology0.94391711
64MP0003806_abnormal_nucleotide_metabolis0.93756577
65MP0001968_abnormal_touch/_nociception0.88414224
66MP0001919_abnormal_reproductive_system0.87079171
67MP0002019_abnormal_tumor_incidence0.83339243
68MP0009765_abnormal_xenobiotic_induced0.74170680
69MP0008995_early_reproductive_senescence0.68436689
70MP0006072_abnormal_retinal_apoptosis0.66727790
71MP0005464_abnormal_platelet_physiology0.65198584
72MP0001663_abnormal_digestive_system0.59217323
73MP0004145_abnormal_muscle_electrophysio0.58984761
74MP0008877_abnormal_DNA_methylation0.58667378
75MP0002736_abnormal_nociception_after0.57308524
76MP0005083_abnormal_biliary_tract0.55914724
77MP0000858_altered_metastatic_potential0.50155729
78MP0000427_abnormal_hair_cycle0.49360339
79MP0005645_abnormal_hypothalamus_physiol0.49064036
80MP0009643_abnormal_urine_homeostasis0.47510211
81MP0003137_abnormal_impulse_conducting0.46181872
82MP0005389_reproductive_system_phenotype0.45944358
83MP0001986_abnormal_taste_sensitivity0.45291311
84MP0000604_amyloidosis0.45068615
85MP0002638_abnormal_pupillary_reflex0.45005612
86MP0000920_abnormal_myelination0.44858160
87MP0000609_abnormal_liver_physiology0.43890387
88MP0004043_abnormal_pH_regulation0.43673652
89MP0002136_abnormal_kidney_physiology0.42135787
90MP0000613_abnormal_salivary_gland0.42124753
91MP0008875_abnormal_xenobiotic_pharmacok0.40247134
92MP0005253_abnormal_eye_physiology0.39795220
93MP0003011_delayed_dark_adaptation0.37970911
94MP0002089_abnormal_postnatal_growth/wei0.36968419
95MP0010307_abnormal_tumor_latency0.36172585
96MP0002998_abnormal_bone_remodeling0.35766023
97MP0001191_abnormal_skin_condition0.35320334
98MP0001765_abnormal_ion_homeostasis0.33534096
99MP0005166_decreased_susceptibility_to0.33489802
100MP0005636_abnormal_mineral_homeostasis0.33093482

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)7.83653015
2Abnormality of T cell number (HP:0011839)7.09611548
3T lymphocytopenia (HP:0005403)6.77468767
4Retrobulbar optic neuritis (HP:0100654)6.48438939
5Optic neuritis (HP:0100653)6.48438939
6IgG deficiency (HP:0004315)6.26351024
7Orchitis (HP:0100796)5.69546960
8Autoimmune hemolytic anemia (HP:0001890)5.64360216
9Myositis (HP:0100614)5.44121164
10Encephalitis (HP:0002383)5.35738176
11Abnormality of T cells (HP:0002843)4.88364861
12Keratoconjunctivitis sicca (HP:0001097)4.68329180
13Stomatitis (HP:0010280)4.52801454
14Keratoconjunctivitis (HP:0001096)4.48581927
15Pulmonary infiltrates (HP:0002113)4.39328513
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.38310184
17Abnormality of eosinophils (HP:0001879)4.14279767
18Eosinophilia (HP:0001880)3.99551270
19Joint swelling (HP:0001386)3.98410615
20Hypoproteinemia (HP:0003075)3.92168875
21Chronic diarrhea (HP:0002028)3.78402914
22Severe combined immunodeficiency (HP:0004430)3.75333670
23Meningitis (HP:0001287)3.60647456
24Gangrene (HP:0100758)3.51390190
25Elevated erythrocyte sedimentation rate (HP:0003565)3.48176478
26Granulocytopenia (HP:0001913)3.48089791
27Keratitis (HP:0000491)3.42057107
28Hemoptysis (HP:0002105)3.39143537
29Autoimmune thrombocytopenia (HP:0001973)3.31259508
30Abnormality of T cell physiology (HP:0011840)3.28959491
31Acute hepatic failure (HP:0006554)3.28846604
32Hypergammaglobulinemia (HP:0010702)3.20458740
33Pustule (HP:0200039)3.16621455
34Leukocytosis (HP:0001974)3.14556264
35Aplastic anemia (HP:0001915)3.13261409
36Recurrent fungal infections (HP:0002841)3.02054044
373-Methylglutaconic aciduria (HP:0003535)2.95918109
38Vasculitis (HP:0002633)2.94795820
39Pulmonary embolism (HP:0002204)2.89457592
40Combined immunodeficiency (HP:0005387)2.85951094
41IgA deficiency (HP:0002720)2.83841325
42Thyroiditis (HP:0100646)2.83453779
43IgM deficiency (HP:0002850)2.82684346
44Congenital stationary night blindness (HP:0007642)2.81290062
45Mediastinal lymphadenopathy (HP:0100721)2.80359694
46Chronic mucocutaneous candidiasis (HP:0002728)2.80019356
47Recurrent cutaneous fungal infections (HP:0011370)2.80019356
48Recurrent viral infections (HP:0004429)2.72844049
49Anorexia (HP:0002039)2.71254763
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.65174379
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.57707022
52Arterial thrombosis (HP:0004420)2.56219285
53Hypochromic anemia (HP:0001931)2.51266104
54Recurrent bronchitis (HP:0002837)2.50158206
55Abnormality of the pleura (HP:0002103)2.48658091
56Pancytopenia (HP:0001876)2.47191550
57Abnormality of macrophages (HP:0004311)2.45262612
58Abnormality of the prostate (HP:0008775)2.34741281
59Abnormal albumin level (HP:0012116)2.33049507
60Hypoalbuminemia (HP:0003073)2.33049507
61Glomerulopathy (HP:0100820)2.27697011
62Lymphopenia (HP:0001888)2.26626817
63Hypoplasia of the thymus (HP:0000778)2.21714486
64Polyneuropathy (HP:0001271)2.21228701
65Pancreatitis (HP:0001733)2.19509183
66Lymphoma (HP:0002665)2.15842152
67Abnormality of the pericardium (HP:0001697)2.13040434
68Gastrointestinal infarctions (HP:0005244)2.03871036
69Eczematoid dermatitis (HP:0000976)2.03576171
70Chronic obstructive pulmonary disease (HP:0006510)2.02046086
71Obstructive lung disease (HP:0006536)2.02046086
72Oral leukoplakia (HP:0002745)2.01592719
73Agammaglobulinemia (HP:0004432)2.00347718
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00267378
75Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00267378
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97896391
77Radial bowing (HP:0002986)1.94884234
78Renal cortical cysts (HP:0000803)1.94458109
79Thrombophlebitis (HP:0004418)1.94268612
80Cellular immunodeficiency (HP:0005374)1.85042923
81Chest pain (HP:0100749)1.81647565
82Loss of speech (HP:0002371)1.79624635
83Panhypogammaglobulinemia (HP:0003139)1.78720937
84Increased intramyocellular lipid droplets (HP:0012240)1.78690248
85Skin rash (HP:0000988)1.77295300
86Vertigo (HP:0002321)1.77033502
87Recurrent skin infections (HP:0001581)1.76601820
88Recurrent abscess formation (HP:0002722)1.76333186
89Mitochondrial inheritance (HP:0001427)1.73526945
90Increased muscle lipid content (HP:0009058)1.73290559
91Ureteral stenosis (HP:0000071)1.68265553
92Ureteral obstruction (HP:0006000)1.66475417
93Papilloma (HP:0012740)1.66082897
94Verrucae (HP:0200043)1.66082897
95Recurrent bacterial skin infections (HP:0005406)1.64506508
96Abnormality of the renal cortex (HP:0011035)1.63726307
97Acute necrotizing encephalopathy (HP:0006965)1.60164796
98Paresthesia (HP:0003401)1.59258843
99Acne (HP:0001061)1.55189526
100Stenosis of the external auditory canal (HP:0000402)1.54968182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.33126514
2KDR3.89261620
3MAP4K13.25758862
4ITK2.85295146
5TGFBR22.82184500
6EPHB12.81148919
7MAP2K62.78603079
8BCR2.60924738
9GRK62.17177811
10GRK72.02291715
11FES1.95633653
12CAMKK21.95369746
13BTK1.91619018
14CLK11.91423675
15CSK1.84491199
16EPHA31.83663890
17TEC1.75784580
18PASK1.73235156
19NME11.66017882
20TLK11.53068008
21LCK1.50784653
22MAP3K111.49056161
23NLK1.48690940
24TESK21.48340836
25MAPKAPK31.45200060
26SYK1.42647746
27ADRBK21.32530944
28IKBKB1.31386341
29NEK61.27956983
30MARK31.27696848
31VRK21.26633807
32ACVR1B1.24158112
33CAMKK11.24153655
34MAP3K141.18793925
35PRKCQ1.13296024
36DAPK21.13001219
37FGFR41.09327903
38IKBKE1.05634863
39LYN0.98625451
40JAK30.92663331
41TSSK60.92047219
42PIM10.89944839
43SIK30.87523578
44WNK40.85209122
45JAK20.84502117
46STK100.83554275
47HCK0.82109868
48MAPK110.80654234
49TAOK10.79709534
50MST40.76835731
51JAK10.73707788
52ZAP700.73696626
53GRK10.65853872
54TAOK30.64938711
55TBK10.62698961
56FYN0.61616590
57GRK50.61278815
58IRAK10.59385440
59MAPKAPK20.56614042
60DAPK10.55387346
61FRK0.55119494
62NUAK10.54124101
63FGFR30.52143594
64NEK90.51360957
65TYK20.49469679
66PDK10.47480529
67MAP3K70.47258981
68TRPM70.46461626
69FER0.46066143
70MELK0.44909677
71OXSR10.44352433
72BCKDK0.43357518
73VRK10.43250869
74MAP3K130.42506550
75STK110.38517940
76CDK60.38327916
77PTK2B0.36048429
78IGF1R0.35819567
79ALK0.35293465
80PRKCD0.31752186
81IRAK40.31232386
82CDK40.29609080
83ZAK0.29146714
84TAOK20.28885729
85TYRO30.27802963
86RPS6KB20.26717522
87KIT0.26470399
88PAK40.23025063
89PRKCH0.22479602
90EIF2AK10.21587856
91RIPK40.21566706
92PRKCA0.21185478
93MAP3K120.20649142
94CAMK2A0.19514778
95HIPK20.16690668
96FGFR10.15996672
97PRKCB0.15734780
98MAP3K30.15574092
99LRRK20.15052835
100RPS6KA50.15010842

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.33493477
2Autoimmune thyroid disease_Homo sapiens_hsa053203.61572597
3T cell receptor signaling pathway_Homo sapiens_hsa046603.41667136
4Antigen processing and presentation_Homo sapiens_hsa046123.38095674
5Allograft rejection_Homo sapiens_hsa053303.25664034
6Graft-versus-host disease_Homo sapiens_hsa053323.24226862
7Hematopoietic cell lineage_Homo sapiens_hsa046403.11584153
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.93829913
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.91095248
10Measles_Homo sapiens_hsa051622.79121352
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.74636416
12Type I diabetes mellitus_Homo sapiens_hsa049402.56172382
13Proteasome_Homo sapiens_hsa030502.41375541
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.35395831
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.19835978
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.78959732
17Rheumatoid arthritis_Homo sapiens_hsa053231.67488678
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63940032
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.56437548
20Linoleic acid metabolism_Homo sapiens_hsa005911.45759514
21Chemokine signaling pathway_Homo sapiens_hsa040621.43153187
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41872504
23Shigellosis_Homo sapiens_hsa051311.34403575
24Oxidative phosphorylation_Homo sapiens_hsa001901.33672411
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31776658
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24263274
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18011725
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09637950
29Parkinsons disease_Homo sapiens_hsa050121.02477011
30RNA polymerase_Homo sapiens_hsa030201.02281867
31Asthma_Homo sapiens_hsa053100.96786937
32TNF signaling pathway_Homo sapiens_hsa046680.96714571
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95608327
34Ribosome_Homo sapiens_hsa030100.95337929
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90366910
36Viral myocarditis_Homo sapiens_hsa054160.87125384
37Malaria_Homo sapiens_hsa051440.85900567
38Salmonella infection_Homo sapiens_hsa051320.85206406
39Herpes simplex infection_Homo sapiens_hsa051680.83772961
40Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83759385
41Phototransduction_Homo sapiens_hsa047440.83231633
42Homologous recombination_Homo sapiens_hsa034400.81551996
43Staphylococcus aureus infection_Homo sapiens_hsa051500.78796940
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74694176
45Non-homologous end-joining_Homo sapiens_hsa034500.74044874
46African trypanosomiasis_Homo sapiens_hsa051430.73600919
47Osteoclast differentiation_Homo sapiens_hsa043800.72850304
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71910428
49Fatty acid biosynthesis_Homo sapiens_hsa000610.71857475
50Nitrogen metabolism_Homo sapiens_hsa009100.69638605
51Alzheimers disease_Homo sapiens_hsa050100.63691690
52Apoptosis_Homo sapiens_hsa042100.62675770
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61347566
54HTLV-I infection_Homo sapiens_hsa051660.60160291
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58347853
56One carbon pool by folate_Homo sapiens_hsa006700.57155095
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56543780
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54766320
59Caffeine metabolism_Homo sapiens_hsa002320.52972286
60Pyrimidine metabolism_Homo sapiens_hsa002400.51674061
61Epstein-Barr virus infection_Homo sapiens_hsa051690.46686654
62Influenza A_Homo sapiens_hsa051640.44858432
63Propanoate metabolism_Homo sapiens_hsa006400.42058578
64Protein export_Homo sapiens_hsa030600.41818967
65Ether lipid metabolism_Homo sapiens_hsa005650.41544425
66Hepatitis B_Homo sapiens_hsa051610.41474186
67Viral carcinogenesis_Homo sapiens_hsa052030.40915048
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.40411307
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39746759
70Leishmaniasis_Homo sapiens_hsa051400.39407469
71Tuberculosis_Homo sapiens_hsa051520.39263179
72Endocytosis_Homo sapiens_hsa041440.39011636
73Fanconi anemia pathway_Homo sapiens_hsa034600.38688825
74Legionellosis_Homo sapiens_hsa051340.38413778
75Pertussis_Homo sapiens_hsa051330.37440615
76Arachidonic acid metabolism_Homo sapiens_hsa005900.34949304
77Chemical carcinogenesis_Homo sapiens_hsa052040.34558785
78Toxoplasmosis_Homo sapiens_hsa051450.33067548
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.32170448
80Huntingtons disease_Homo sapiens_hsa050160.31558484
81p53 signaling pathway_Homo sapiens_hsa041150.29097152
82Olfactory transduction_Homo sapiens_hsa047400.28908044
83Cardiac muscle contraction_Homo sapiens_hsa042600.28358500
84Glycerolipid metabolism_Homo sapiens_hsa005610.26358583
85B cell receptor signaling pathway_Homo sapiens_hsa046620.26007385
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25002419
87Systemic lupus erythematosus_Homo sapiens_hsa053220.24395099
88Purine metabolism_Homo sapiens_hsa002300.24309746
89Retinol metabolism_Homo sapiens_hsa008300.23534021
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22337891
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20929197
92Platelet activation_Homo sapiens_hsa046110.20680906
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19133857
94Collecting duct acid secretion_Homo sapiens_hsa049660.17228598
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.16942736
96RNA degradation_Homo sapiens_hsa030180.16411711
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.16263370
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15582166
99Ovarian steroidogenesis_Homo sapiens_hsa049130.12564565
100Morphine addiction_Homo sapiens_hsa050320.11909204

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