TRAV41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1T cell migration (GO:0072678)7.97917955
2negative thymic T cell selection (GO:0045060)7.18131014
3negative T cell selection (GO:0043383)6.81923762
4positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.77435788
5amyloid precursor protein catabolic process (GO:0042987)5.75689182
6positive regulation of alpha-beta T cell proliferation (GO:0046641)5.74007258
7positive regulation of B cell differentiation (GO:0045579)5.69425381
8mast cell activation (GO:0045576)5.62812577
9positive regulation of gamma-delta T cell activation (GO:0046645)5.40185744
10regulation of alpha-beta T cell proliferation (GO:0046640)5.27508111
11thymic T cell selection (GO:0045061)5.25242662
12regulation of isotype switching to IgG isotypes (GO:0048302)5.23219305
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.14361997
14mast cell degranulation (GO:0043303)4.74550331
15mast cell activation involved in immune response (GO:0002279)4.74550331
16leukocyte aggregation (GO:0070486)4.69263736
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.67405479
18regulation of gamma-delta T cell differentiation (GO:0045586)4.56342309
19positive regulation of interleukin-4 production (GO:0032753)4.56308873
20regulation of T cell tolerance induction (GO:0002664)4.39946697
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30587149
22positive regulation of tolerance induction (GO:0002645)4.30110371
23lymphocyte migration (GO:0072676)4.16884523
24T cell receptor signaling pathway (GO:0050852)4.15951209
25T cell selection (GO:0045058)4.15059292
26cellular extravasation (GO:0045123)4.13994875
27positive regulation of natural killer cell mediated immunity (GO:0002717)4.07933981
28positive regulation of granulocyte differentiation (GO:0030854)4.07749129
29regulation of interleukin-2 biosynthetic process (GO:0045076)4.07642856
30autophagic vacuole fusion (GO:0000046)4.07576276
31sensory perception of taste (GO:0050909)4.05781236
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05307502
33respiratory burst (GO:0045730)4.04345934
34Arp2/3 complex-mediated actin nucleation (GO:0034314)4.04149445
35cytokine biosynthetic process (GO:0042089)4.00946839
36antigen processing and presentation of endogenous antigen (GO:0019883)3.97015784
37regulation of B cell differentiation (GO:0045577)3.90915567
38cell wall macromolecule metabolic process (GO:0044036)3.89721905
39positive regulation of T cell cytokine production (GO:0002726)3.88705467
40positive regulation of chemokine secretion (GO:0090197)3.87089431
41regulation of gamma-delta T cell activation (GO:0046643)3.85694746
42positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.84943601
43positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.84914623
44regulation of interleukin-4 production (GO:0032673)3.84906418
45positive thymic T cell selection (GO:0045059)3.80752654
46regulation of triglyceride catabolic process (GO:0010896)3.78735972
47amyloid precursor protein metabolic process (GO:0042982)3.78129759
48ether lipid metabolic process (GO:0046485)3.75190461
49ribosomal small subunit assembly (GO:0000028)3.72605642
50T cell costimulation (GO:0031295)3.69872835
51positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.67721475
52actin nucleation (GO:0045010)3.67592709
53regulation of B cell receptor signaling pathway (GO:0050855)3.67501057
54lymphocyte costimulation (GO:0031294)3.65681790
55regulation of chemokine secretion (GO:0090196)3.64586719
56regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.63885036
57regulation of natural killer cell mediated immunity (GO:0002715)3.63885036
58regulation of tolerance induction (GO:0002643)3.62551787
59response to interleukin-15 (GO:0070672)3.61441794
60hepatocyte apoptotic process (GO:0097284)3.61430893
61positive regulation of interleukin-2 production (GO:0032743)3.59863615
62cellular response to interleukin-15 (GO:0071350)3.58496546
63positive regulation of calcium-mediated signaling (GO:0050850)3.56842995
64positive regulation of hair follicle development (GO:0051798)3.56786625
65positive regulation of hair cycle (GO:0042635)3.56786625
66response to interferon-beta (GO:0035456)3.54713147
67lymphocyte chemotaxis (GO:0048247)3.47615937
68cytokine metabolic process (GO:0042107)3.40637529
69negative regulation of stress fiber assembly (GO:0051497)3.40571060
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38078943
71purine ribonucleotide transport (GO:0015868)3.37049688
72regulation of defense response to virus by virus (GO:0050690)3.34902300
73positive regulation of cell killing (GO:0031343)3.33036082
74antigen receptor-mediated signaling pathway (GO:0050851)3.31952753
75DNA deamination (GO:0045006)3.30826183
76production of molecular mediator involved in inflammatory response (GO:0002532)3.28836086
77positive regulation of immunoglobulin production (GO:0002639)3.27730957
78positive regulation of isotype switching (GO:0045830)3.26212324
79positive T cell selection (GO:0043368)3.23841460
80negative regulation of T cell apoptotic process (GO:0070233)3.22878410
81negative regulation of cell killing (GO:0031342)3.22124866
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22124866
83regulation of leukocyte mediated cytotoxicity (GO:0001910)3.21528950
84epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.19637004
85detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.16433944
86positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10964105
87rRNA catabolic process (GO:0016075)3.10222031
88positive regulation of viral genome replication (GO:0045070)3.09665000
89cellular response to prostaglandin stimulus (GO:0071379)3.06019321
90positive regulation of lymphocyte mediated immunity (GO:0002708)3.03985259
91negative regulation of nitric-oxide synthase activity (GO:0051001)3.03172213
92negative regulation of defense response to virus (GO:0050687)3.02173113
93adenine nucleotide transport (GO:0051503)3.01764693
94organelle membrane fusion (GO:0090174)2.98476700
95viral transcription (GO:0019083)2.97194049
96positive regulation of T cell mediated immunity (GO:0002711)2.96997426
97positive regulation of alpha-beta T cell activation (GO:0046635)2.95048921
98regulation of regulatory T cell differentiation (GO:0045589)2.93063495
99regulation of defense response to virus by host (GO:0050691)2.92315573
100regulation of T cell cytokine production (GO:0002724)2.91858290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.30651986
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.83808305
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.07498392
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.18349080
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.99301711
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.98133967
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80697178
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.80277561
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62168136
10RUNX_20019798_ChIP-Seq_JUKART_Human3.37154517
11MYB_26560356_Chip-Seq_TH2_Human2.99202480
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.81190091
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.75584913
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38560473
15GATA3_27048872_Chip-Seq_THYMUS_Human2.38469566
16EZH2_22144423_ChIP-Seq_EOC_Human2.36272609
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.32673048
18MYB_26560356_Chip-Seq_TH1_Human2.27545369
19UTX_26944678_Chip-Seq_JUKART_Human2.23701231
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13971367
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05520028
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01684724
23GATA3_26560356_Chip-Seq_TH2_Human1.97607214
24MAF_26560356_Chip-Seq_TH1_Human1.91917335
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91436765
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81122722
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79065990
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66317738
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62999160
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59150447
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57224154
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55724585
33SPI1_23547873_ChIP-Seq_NB4_Human1.53066532
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51143049
35MAF_26560356_Chip-Seq_TH2_Human1.47277522
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35281544
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34946918
38VDR_23849224_ChIP-Seq_CD4+_Human1.33617685
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32695687
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.27827972
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25977308
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25540880
43ERG_20517297_ChIP-Seq_VCAP_Human1.23046963
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22955903
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22955903
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22955903
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22881105
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.21738855
49MYC_22102868_ChIP-Seq_BL_Human1.16960291
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11312421
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11116513
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10273410
53TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09749996
54BCL6_27268052_Chip-Seq_Bcells_Human1.09603524
55SOX2_21211035_ChIP-Seq_LN229_Human1.08882327
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08316429
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.07218197
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05698398
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03466328
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02881245
61IGF1R_20145208_ChIP-Seq_DFB_Human1.02740695
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02417379
63FOXP3_21729870_ChIP-Seq_TREG_Human1.01400777
64VDR_24763502_ChIP-Seq_THP-1_Human0.98935973
65FLI1_27457419_Chip-Seq_LIVER_Mouse0.98373493
66SPI1_20517297_ChIP-Seq_HL60_Human0.97038983
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93079871
68GATA3_26560356_Chip-Seq_TH1_Human0.92634645
69EGR1_19032775_ChIP-ChIP_M12_Human0.91865319
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91739804
71P300_27268052_Chip-Seq_Bcells_Human0.91732194
72PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90622225
73BCOR_27268052_Chip-Seq_Bcells_Human0.90246667
74ELK1_22589737_ChIP-Seq_MCF10A_Human0.89481890
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88379422
76AR_20517297_ChIP-Seq_VCAP_Human0.87486309
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87231252
78WDR5_24793694_ChIP-Seq_LNCAP_Human0.86696218
79SPI1_23127762_ChIP-Seq_K562_Human0.85059467
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83920157
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81952956
82SMRT_27268052_Chip-Seq_Bcells_Human0.80931334
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.80924713
84GABP_17652178_ChIP-ChIP_JURKAT_Human0.80908187
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80782815
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80410088
87SA1_27219007_Chip-Seq_Bcells_Human0.79768095
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79013655
89MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78755006
90SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78567257
91STAT1_20625510_ChIP-Seq_HELA_Human0.77231615
92SCL_19346495_ChIP-Seq_HPC-7_Human0.76893881
93PHF8_20622854_ChIP-Seq_HELA_Human0.74885420
94BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74828485
95EST1_17652178_ChIP-ChIP_JURKAT_Human0.73645639
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.73598038
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72622030
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72157032
99ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71216042
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69001529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.70219606
2MP0003183_abnormal_peptide_metabolism4.47585465
3MP0003763_abnormal_thymus_physiology3.86355761
4MP0003011_delayed_dark_adaptation3.58541691
5MP0009785_altered_susceptibility_to3.58332041
6MP0003191_abnormal_cellular_cholesterol3.36509114
7MP0002277_abnormal_respiratory_mucosa3.34164253
8MP0001800_abnormal_humoral_immune2.70196602
9MP0009840_abnormal_foam_cell2.68440520
10MP0005000_abnormal_immune_tolerance2.66666541
11MP0002148_abnormal_hypersensitivity_rea2.66067989
12MP0003436_decreased_susceptibility_to2.63776559
13MP0001835_abnormal_antigen_presentation2.63486771
14MP0005025_abnormal_response_to2.63174729
15MP0002420_abnormal_adaptive_immunity2.39602951
16MP0002723_abnormal_immune_serum2.35496749
17MP0001819_abnormal_immune_cell2.32598612
18MP0004381_abnormal_hair_follicle2.30142795
19MP0002452_abnormal_antigen_presenting2.30109537
20MP0003724_increased_susceptibility_to2.28073738
21MP0002405_respiratory_system_inflammati2.25855082
22MP0002138_abnormal_hepatobiliary_system2.24062602
23MP0000685_abnormal_immune_system2.09411233
24MP0000716_abnormal_immune_system2.01583454
25MP0004145_abnormal_muscle_electrophysio2.01004752
26MP0002419_abnormal_innate_immunity1.91153251
27MP0002398_abnormal_bone_marrow1.90023644
28MP0004947_skin_inflammation1.88628846
29MP0010155_abnormal_intestine_physiology1.88175562
30MP0003045_fibrosis1.82832320
31MP0003866_abnormal_defecation1.82211604
32MP0000703_abnormal_thymus_morphology1.81582236
33MP0009333_abnormal_splenocyte_physiolog1.81436258
34MP0001790_abnormal_immune_system1.78981673
35MP0005387_immune_system_phenotype1.78981673
36MP0005410_abnormal_fertilization1.66802428
37MP0001845_abnormal_inflammatory_respons1.61527726
38MP0005451_abnormal_body_composition1.52601994
39MP0002429_abnormal_blood_cell1.43410785
40MP0002722_abnormal_immune_system1.40248584
41MP0005464_abnormal_platelet_physiology1.32627927
42MP0000689_abnormal_spleen_morphology1.30517933
43MP0000604_amyloidosis1.30282035
44MP0001533_abnormal_skeleton_physiology1.22510651
45MP0005075_abnormal_melanosome_morpholog1.13651239
46MP0008961_abnormal_basal_metabolism1.13448922
47MP0001243_abnormal_dermal_layer1.13329752
48MP0000490_abnormal_crypts_of1.11676160
49MP0008789_abnormal_olfactory_epithelium1.10641983
50MP0003448_altered_tumor_morphology1.08379715
51MP0001765_abnormal_ion_homeostasis1.08134010
52MP0003646_muscle_fatigue1.01894472
53MP0003878_abnormal_ear_physiology1.00448390
54MP0005377_hearing/vestibular/ear_phenot1.00448390
55MP0000465_gastrointestinal_hemorrhage0.96760349
56MP0004036_abnormal_muscle_relaxation0.96414770
57MP0002693_abnormal_pancreas_physiology0.95867036
58MP0000920_abnormal_myelination0.95701731
59MP0008469_abnormal_protein_level0.95299817
60MP0001853_heart_inflammation0.94231325
61MP0005670_abnormal_white_adipose0.92851702
62MP0003300_gastrointestinal_ulcer0.91970017
63MP0005645_abnormal_hypothalamus_physiol0.84474812
64MP0009278_abnormal_bone_marrow0.82584619
65MP0003075_altered_response_to0.81913507
66MP0002998_abnormal_bone_remodeling0.77482621
67MP0005503_abnormal_tendon_morphology0.77306236
68MP0004084_abnormal_cardiac_muscle0.76917925
69MP0002095_abnormal_skin_pigmentation0.73850545
70MP0009763_increased_sensitivity_to0.73173172
71MP0001663_abnormal_digestive_system0.72177833
72MP0003279_aneurysm0.71408405
73MP0002933_joint_inflammation0.69841007
74MP0001879_abnormal_lymphatic_vessel0.69013402
75MP0005394_taste/olfaction_phenotype0.68539390
76MP0005499_abnormal_olfactory_system0.68539390
77MP0003195_calcinosis0.67330160
78MP0009384_cardiac_valve_regurgitation0.66956478
79MP0008995_early_reproductive_senescence0.65383503
80MP0002168_other_aberrant_phenotype0.64552471
81MP0000678_abnormal_parathyroid_gland0.64243141
82MP0002019_abnormal_tumor_incidence0.64147412
83MP0002127_abnormal_cardiovascular_syste0.61858841
84MP0001873_stomach_inflammation0.61115200
85MP0009053_abnormal_anal_canal0.60556338
86MP0003690_abnormal_glial_cell0.60144344
87MP0006276_abnormal_autonomic_nervous0.59667190
88MP0005584_abnormal_enzyme/coenzyme_acti0.59236861
89MP0002166_altered_tumor_susceptibility0.58793318
90MP0000639_abnormal_adrenal_gland0.57986453
91MP0002136_abnormal_kidney_physiology0.57951241
92MP0003959_abnormal_lean_body0.56823975
93MP0009643_abnormal_urine_homeostasis0.56239588
94MP0008872_abnormal_physiological_respon0.56121302
95MP0000858_altered_metastatic_potential0.54991243
96MP0002006_tumorigenesis0.53901606
97MP0003795_abnormal_bone_structure0.51750448
98MP0004782_abnormal_surfactant_physiolog0.50596395
99MP0005448_abnormal_energy_balance0.49026437
100MP0005166_decreased_susceptibility_to0.48708051

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.94666819
2T lymphocytopenia (HP:0005403)5.48079511
3Elevated erythrocyte sedimentation rate (HP:0003565)5.07643326
4Abnormality of T cell number (HP:0011839)4.75719390
5Stomatitis (HP:0010280)3.89504432
6Attenuation of retinal blood vessels (HP:0007843)3.78994391
7Type 2 muscle fiber atrophy (HP:0003554)3.66469926
8Vacuolated lymphocytes (HP:0001922)3.55544538
9Severe combined immunodeficiency (HP:0004430)3.52944004
10Panhypogammaglobulinemia (HP:0003139)3.43865349
11Abnormality of T cells (HP:0002843)3.43271442
12Easy fatigability (HP:0003388)3.38833424
133-Methylglutaconic aciduria (HP:0003535)3.36928128
14Flat capital femoral epiphysis (HP:0003370)3.32260303
15Myositis (HP:0100614)3.31468317
16Global brain atrophy (HP:0002283)3.27116457
17Chronic otitis media (HP:0000389)3.16373716
18IgG deficiency (HP:0004315)3.15233873
19Muscle fiber atrophy (HP:0100295)3.12374438
20Decreased electroretinogram (ERG) amplitude (HP:0000654)3.09517708
21Spontaneous hematomas (HP:0007420)2.99663025
22Abnormality of the columella (HP:0009929)2.84370161
23Abnormality of the parietal bone (HP:0002696)2.84129885
24Hypoplasia of the pons (HP:0012110)2.83028464
25Autoimmune hemolytic anemia (HP:0001890)2.81669917
26Thrombocytosis (HP:0001894)2.77126340
27Retinal atrophy (HP:0001105)2.75092448
28Anhidrosis (HP:0000970)2.69106085
29Spastic tetraparesis (HP:0001285)2.68601596
30Combined immunodeficiency (HP:0005387)2.68361406
31Inflammation of the large intestine (HP:0002037)2.68197343
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.65413088
33Colitis (HP:0002583)2.65238251
34Papilledema (HP:0001085)2.62542684
35Chronic mucocutaneous candidiasis (HP:0002728)2.49739138
36Recurrent cutaneous fungal infections (HP:0011370)2.49739138
37Chronic hepatic failure (HP:0100626)2.49562113
38Agammaglobulinemia (HP:0004432)2.48801154
39Gastrointestinal inflammation (HP:0004386)2.48576581
40Optic nerve coloboma (HP:0000588)2.48546912
41Lymphopenia (HP:0001888)2.47016257
42Dyschromatopsia (HP:0007641)2.44929927
43Abnormal pupillary function (HP:0007686)2.44743040
44Pancreatic cysts (HP:0001737)2.43852021
45Abnormality of the pons (HP:0007361)2.42676748
46Encephalitis (HP:0002383)2.42396638
47Recurrent viral infections (HP:0004429)2.42144481
48Increased intramyocellular lipid droplets (HP:0012240)2.40920986
49Recurrent fungal infections (HP:0002841)2.39260980
50Recurrent bronchitis (HP:0002837)2.39213517
51Congenital stationary night blindness (HP:0007642)2.35366754
52Congenital sensorineural hearing impairment (HP:0008527)2.35280778
53Periodontitis (HP:0000704)2.32569302
54Abnormal biliary tract physiology (HP:0012439)2.32349065
55Bile duct proliferation (HP:0001408)2.32349065
56Chronic diarrhea (HP:0002028)2.32186726
57Abnormality of the neuromuscular junction (HP:0003398)2.28595808
58Fatigable weakness (HP:0003473)2.28595808
59Reduced antithrombin III activity (HP:0001976)2.27802316
60Centrally nucleated skeletal muscle fibers (HP:0003687)2.25882660
61Thyroiditis (HP:0100646)2.25139990
62Retrobulbar optic neuritis (HP:0100654)2.23797684
63Optic neuritis (HP:0100653)2.23797684
64IgM deficiency (HP:0002850)2.23009460
65Recurrent bacterial skin infections (HP:0005406)2.22682829
66Premature loss of primary teeth (HP:0006323)2.22113669
67Recurrent abscess formation (HP:0002722)2.19795580
68Decreased central vision (HP:0007663)2.18406172
69Hypoplasia of the thymus (HP:0000778)2.16755674
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.15103743
71Hypoalbuminemia (HP:0003073)2.13083298
72Abnormal albumin level (HP:0012116)2.13083298
73True hermaphroditism (HP:0010459)2.12730851
74Increased muscle lipid content (HP:0009058)2.11703427
75Nasal polyposis (HP:0100582)2.11190623
76Recurrent skin infections (HP:0001581)2.10891337
77Abolished electroretinogram (ERG) (HP:0000550)2.09022910
78Abnormality of macrophages (HP:0004311)2.07874719
79Orchitis (HP:0100796)2.06375553
80Hypoproteinemia (HP:0003075)2.05629236
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04324667
82Eczematoid dermatitis (HP:0000976)2.03296705
83Retinal dysplasia (HP:0007973)2.02864576
84Bronchiectasis (HP:0002110)1.96991305
85Renal dysplasia (HP:0000110)1.96011235
86Asplenia (HP:0001746)1.95784025
87Pancreatic fibrosis (HP:0100732)1.95100955
88Delayed CNS myelination (HP:0002188)1.94730900
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.93825024
90Long nose (HP:0003189)1.93388601
91Increased hepatocellular lipid droplets (HP:0006565)1.93322693
92Malignant hyperthermia (HP:0002047)1.92135914
93Keratoconjunctivitis sicca (HP:0001097)1.91744189
94Weak cry (HP:0001612)1.90685387
95Nonprogressive disorder (HP:0003680)1.89839440
96Meningitis (HP:0001287)1.88881222
97Occipital encephalocele (HP:0002085)1.88206843
98Chronic sinusitis (HP:0011109)1.84160601
99Bronchitis (HP:0012387)1.84069281
100Cerebellar dysplasia (HP:0007033)1.82969193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK27.62616777
2MUSK7.51549906
3SCYL24.54131033
4PIK3CG4.26177493
5TXK4.01569304
6RIPK13.06305790
7MAP4K12.84026437
8IKBKE2.73391386
9PASK2.41771985
10TBK12.15033056
11ZAP702.13197529
12KDR2.05850659
13ITK1.99609900
14FES1.53988122
15GRK61.47453387
16TYK21.45289048
17CAMKK11.42139809
18MAP3K101.39385265
19BTK1.32028580
20LCK1.20537669
21SYK1.18705918
22TESK11.17499086
23NEK61.15814709
24BLK1.05498977
25CSK1.02731025
26CSF1R1.02294182
27IKBKB1.01390254
28MAP3K131.00765675
29IRAK41.00000710
30TNK20.99375623
31CAMKK20.98048330
32LIMK10.86609669
33LYN0.81538776
34PIM20.76898343
35CDK80.73297285
36TEC0.72216560
37MAP3K110.68627804
38JAK30.68481354
39PDGFRB0.65059775
40IRAK10.64866278
41HCK0.60369140
42ADRBK20.58083127
43NLK0.56851713
44PIM10.54773178
45TRIB30.53567609
46PDK10.51684997
47EIF2AK30.49516933
48ARAF0.48814929
49MAP2K60.48733221
50IGF1R0.48683439
51FYN0.48328819
52PRKCH0.48237196
53BUB10.45602337
54LRRK20.45566391
55MAP3K90.41546707
56FLT30.40810365
57PRKCQ0.40641482
58MAP3K30.40453207
59TAOK20.36539832
60SIK30.34780593
61MAP3K140.34491332
62IRAK20.33505573
63CDK60.31599065
64RIPK40.29679168
65MYLK0.28791559
66PAK10.28668590
67OBSCN0.28603382
68FGR0.28343232
69PRKCB0.26905830
70EGFR0.26190158
71TAOK10.26032158
72INSRR0.25954200
73STK380.25618229
74STK110.24713790
75MAPK110.22991604
76VRK10.22951202
77JAK10.22448711
78NME10.20994107
79TRIM280.20421335
80EPHA40.19630851
81TYRO30.19571808
82FRK0.19227253
83JAK20.18683563
84PRKD10.18591293
85RPS6KL10.18492151
86RPS6KC10.18492151
87RPS6KA60.18448422
88CHUK0.17843446
89INSR0.17809773
90GRK70.17645363
91MAP3K70.17428458
92STK100.17308944
93PAK30.17094328
94STK40.16593534
95PRKCA0.16526371
96KIT0.15826064
97MAP3K120.14195493
98EIF2AK10.13956455
99ADRBK10.13879269
100NTRK10.13862611

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.58724237
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.44490610
3T cell receptor signaling pathway_Homo sapiens_hsa046603.12853323
4Ribosome_Homo sapiens_hsa030102.99616877
5Hematopoietic cell lineage_Homo sapiens_hsa046402.89183866
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.77787722
7Graft-versus-host disease_Homo sapiens_hsa053322.48337836
8Autoimmune thyroid disease_Homo sapiens_hsa053202.39854418
9Allograft rejection_Homo sapiens_hsa053302.39207662
10Measles_Homo sapiens_hsa051622.38717427
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.29906856
12Antigen processing and presentation_Homo sapiens_hsa046122.27865795
13Type I diabetes mellitus_Homo sapiens_hsa049401.91876870
14Taste transduction_Homo sapiens_hsa047421.79033823
15Oxidative phosphorylation_Homo sapiens_hsa001901.73990832
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.69315533
17RNA degradation_Homo sapiens_hsa030181.51638598
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.49773843
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48943465
20Collecting duct acid secretion_Homo sapiens_hsa049661.42790251
21Retinol metabolism_Homo sapiens_hsa008301.39869497
22Osteoclast differentiation_Homo sapiens_hsa043801.39153049
23Rheumatoid arthritis_Homo sapiens_hsa053231.37900492
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36637016
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32925697
26Shigellosis_Homo sapiens_hsa051311.28843962
27Viral myocarditis_Homo sapiens_hsa054161.25084969
28B cell receptor signaling pathway_Homo sapiens_hsa046621.21549454
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.17886911
30Malaria_Homo sapiens_hsa051441.16918427
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16563306
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15698682
33Nitrogen metabolism_Homo sapiens_hsa009101.14555276
34Linoleic acid metabolism_Homo sapiens_hsa005911.12176056
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07186676
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06633125
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06118136
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05973384
39Herpes simplex infection_Homo sapiens_hsa051681.00846637
40Staphylococcus aureus infection_Homo sapiens_hsa051501.00770838
41Platelet activation_Homo sapiens_hsa046110.91322624
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90859551
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86259197
44Legionellosis_Homo sapiens_hsa051340.82311147
45Chemokine signaling pathway_Homo sapiens_hsa040620.80901012
46Hepatitis C_Homo sapiens_hsa051600.78621733
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77240105
48Parkinsons disease_Homo sapiens_hsa050120.76657734
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75392107
50RNA polymerase_Homo sapiens_hsa030200.75282584
51Salmonella infection_Homo sapiens_hsa051320.74572947
52Nucleotide excision repair_Homo sapiens_hsa034200.73911520
53Arachidonic acid metabolism_Homo sapiens_hsa005900.73465178
54ABC transporters_Homo sapiens_hsa020100.72486374
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65753762
56Peroxisome_Homo sapiens_hsa041460.65014929
57Acute myeloid leukemia_Homo sapiens_hsa052210.64761753
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64258424
59Butanoate metabolism_Homo sapiens_hsa006500.62233575
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.62116676
61Cardiac muscle contraction_Homo sapiens_hsa042600.61072743
62TNF signaling pathway_Homo sapiens_hsa046680.60053901
63Epstein-Barr virus infection_Homo sapiens_hsa051690.57852131
64Type II diabetes mellitus_Homo sapiens_hsa049300.54114994
65Pertussis_Homo sapiens_hsa051330.54045362
66Influenza A_Homo sapiens_hsa051640.53828571
67Phagosome_Homo sapiens_hsa041450.52635575
68Non-small cell lung cancer_Homo sapiens_hsa052230.51563813
69Phototransduction_Homo sapiens_hsa047440.51052133
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50852794
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49947082
72Ras signaling pathway_Homo sapiens_hsa040140.49047179
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.47892055
74Viral carcinogenesis_Homo sapiens_hsa052030.45616381
75Tuberculosis_Homo sapiens_hsa051520.45365741
76Rap1 signaling pathway_Homo sapiens_hsa040150.45009061
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44636187
78Leishmaniasis_Homo sapiens_hsa051400.44437754
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42520115
80Systemic lupus erythematosus_Homo sapiens_hsa053220.41021288
81Apoptosis_Homo sapiens_hsa042100.40695950
82Olfactory transduction_Homo sapiens_hsa047400.39433586
83Asthma_Homo sapiens_hsa053100.37821924
84Alzheimers disease_Homo sapiens_hsa050100.37261592
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33579181
86VEGF signaling pathway_Homo sapiens_hsa043700.32919129
87HTLV-I infection_Homo sapiens_hsa051660.31131260
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.29876005
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.29710570
90Toxoplasmosis_Homo sapiens_hsa051450.29088711
91Choline metabolism in cancer_Homo sapiens_hsa052310.28352429
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28032806
93Pyruvate metabolism_Homo sapiens_hsa006200.26563442
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26185227
95Ovarian steroidogenesis_Homo sapiens_hsa049130.24751372
96Prolactin signaling pathway_Homo sapiens_hsa049170.21202321
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20631609
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17928799
99Renin secretion_Homo sapiens_hsa049240.17620920
100Proteasome_Homo sapiens_hsa030500.16543997

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