TRAV5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)8.00403976
2eosinophil chemotaxis (GO:0048245)7.84543690
3regulation of activation of Janus kinase activity (GO:0010533)7.75849341
4negative regulation by host of viral transcription (GO:0043922)7.17613975
5eosinophil migration (GO:0072677)7.04820162
6regulation of mononuclear cell migration (GO:0071675)6.92840385
7regulation of macrophage chemotaxis (GO:0010758)6.49291149
8response to interleukin-15 (GO:0070672)6.18614004
9macrophage chemotaxis (GO:0048246)6.17133454
10gonadal mesoderm development (GO:0007506)6.07879527
11regulation of chronic inflammatory response (GO:0002676)5.52744486
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.27635410
13regulation of lymphocyte chemotaxis (GO:1901623)5.27348691
14regulation of regulatory T cell differentiation (GO:0045589)5.23843560
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.15840085
16DNA deamination (GO:0045006)5.15839036
17positive regulation of calcium-mediated signaling (GO:0050850)5.05325283
18positive regulation of T cell chemotaxis (GO:0010820)5.04647468
19regulation of T cell chemotaxis (GO:0010819)5.04647468
20T cell apoptotic process (GO:0070231)4.98914535
21monocyte chemotaxis (GO:0002548)4.98721353
22regulation of T cell tolerance induction (GO:0002664)4.91163498
23positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.87218871
24regulation of chemokine-mediated signaling pathway (GO:0070099)4.81187885
25positive regulation of natural killer cell mediated immunity (GO:0002717)4.70720844
26pyrimidine nucleoside catabolic process (GO:0046135)4.64891956
27modulation by host of viral transcription (GO:0043921)4.61147317
28modulation by host of symbiont transcription (GO:0052472)4.61147317
29negative T cell selection (GO:0043383)4.58114730
30negative regulation of B cell proliferation (GO:0030889)4.41430315
31granulocyte activation (GO:0036230)4.38458123
32modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.36570271
33lymphocyte apoptotic process (GO:0070227)4.34242382
34negative regulation of viral genome replication (GO:0045071)4.28405531
35positive regulation of monocyte chemotaxis (GO:0090026)4.28010232
36regulation of natural killer cell mediated immunity (GO:0002715)4.27914723
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.27914723
38positive regulation of defense response to virus by host (GO:0002230)4.23289174
39positive regulation of alpha-beta T cell proliferation (GO:0046641)4.21240557
40lymphocyte chemotaxis (GO:0048247)4.19876057
41positive regulation of T cell apoptotic process (GO:0070234)4.15166113
42positive regulation of viral genome replication (GO:0045070)4.10182586
43cellular response to nicotine (GO:0071316)4.08043609
44cellular response to ethanol (GO:0071361)4.01938494
45inflammatory response to antigenic stimulus (GO:0002437)4.01932047
46positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.00166700
47regulation of alpha-beta T cell proliferation (GO:0046640)3.97762336
48regulation of tolerance induction (GO:0002643)3.96983404
49positive T cell selection (GO:0043368)3.96384088
50regulation of T cell receptor signaling pathway (GO:0050856)3.95831336
51regulation of calcium-mediated signaling (GO:0050848)3.94187934
52nerve growth factor signaling pathway (GO:0038180)3.88742120
53T cell migration (GO:0072678)3.86604802
54positive regulation of activated T cell proliferation (GO:0042104)3.85990004
55negative regulation of viral transcription (GO:0032897)3.85775380
56dendritic cell chemotaxis (GO:0002407)3.80678484
57negative regulation of B cell activation (GO:0050869)3.78916992
58positive regulation of tolerance induction (GO:0002645)3.75029873
59negative regulation of T cell apoptotic process (GO:0070233)3.74330050
60regulation of leukocyte mediated cytotoxicity (GO:0001910)3.70221165
61nucleoside diphosphate catabolic process (GO:0009134)3.69924701
62positive regulation of cell killing (GO:0031343)3.68710245
63negative regulation of sodium ion transport (GO:0010766)3.68176875
64positive regulation of lymphocyte migration (GO:2000403)3.67902656
65negative thymic T cell selection (GO:0045060)3.64228979
66T cell costimulation (GO:0031295)3.64061614
67regulation of viral genome replication (GO:0045069)3.61896184
68positive regulation of gamma-delta T cell activation (GO:0046645)3.59883188
69lymphocyte costimulation (GO:0031294)3.59018514
70leukocyte apoptotic process (GO:0071887)3.57595128
71cellular defense response (GO:0006968)3.51896795
72regulation of cell killing (GO:0031341)3.49692348
73thymic T cell selection (GO:0045061)3.46624945
74regulation of interleukin-2 biosynthetic process (GO:0045076)3.40462178
75sarcoplasmic reticulum calcium ion transport (GO:0070296)3.38867409
76positive regulation of translational initiation (GO:0045948)3.38766825
77regulation of interleukin-12 biosynthetic process (GO:0045075)3.38104620
78positive thymic T cell selection (GO:0045059)3.37755179
79neutrophil activation (GO:0042119)3.37542174
80protoporphyrinogen IX biosynthetic process (GO:0006782)3.36314916
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25093730
82lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24363712
83T cell receptor signaling pathway (GO:0050852)3.21510714
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.20867234
85regulation of lymphocyte migration (GO:2000401)3.19427032
86release of sequestered calcium ion into cytosol (GO:0051209)3.18183161
87negative regulation of sequestering of calcium ion (GO:0051283)3.18183161
88regulation of memory T cell differentiation (GO:0043380)3.16990905
89positive regulation of lymphocyte apoptotic process (GO:0070230)3.15431652
90T cell selection (GO:0045058)3.15257610
91positive regulation of fibroblast migration (GO:0010763)3.08818795
92positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07273207
93positive regulation of T cell mediated cytotoxicity (GO:0001916)3.02332747
94regulation of granulocyte chemotaxis (GO:0071622)2.97926308
95negative regulation of T cell receptor signaling pathway (GO:0050860)2.96240273
96negative regulation of viral process (GO:0048525)2.95842884
97cytidine deamination (GO:0009972)10.1685602
98cytidine metabolic process (GO:0046087)10.1685602
99cytidine catabolic process (GO:0006216)10.1685602
100pyrimidine ribonucleoside catabolic process (GO:0046133)10.1103607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.16697934
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.78071737
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.61342134
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.32526180
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10804604
6MYB_26560356_Chip-Seq_TH2_Human2.81810301
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.77292384
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61066631
9RUNX_20019798_ChIP-Seq_JUKART_Human2.46029510
10GATA1_22025678_ChIP-Seq_K562_Human2.30974479
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19955876
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15303680
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02729588
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01722009
15MYB_26560356_Chip-Seq_TH1_Human2.00674673
16BP1_19119308_ChIP-ChIP_Hs578T_Human16.2894972
17GATA3_27048872_Chip-Seq_THYMUS_Human1.93786520
18HTT_18923047_ChIP-ChIP_STHdh_Human1.87344576
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84550053
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83141130
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76411554
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74218106
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64326071
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.64016346
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57590998
26GATA3_26560356_Chip-Seq_TH2_Human1.50793782
27UTX_26944678_Chip-Seq_JUKART_Human1.44906090
28VDR_22108803_ChIP-Seq_LS180_Human1.44422627
29IGF1R_20145208_ChIP-Seq_DFB_Human1.36425881
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33597734
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29159510
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.21185378
33MAF_26560356_Chip-Seq_TH1_Human1.20499984
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20211796
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16703316
36PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14639309
37MAF_26560356_Chip-Seq_TH2_Human1.13793991
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10841373
39PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10240432
40VDR_23849224_ChIP-Seq_CD4+_Human1.08888632
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08887936
42RXR_22108803_ChIP-Seq_LS180_Human1.06852867
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06201476
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04920558
45ZNF274_21170338_ChIP-Seq_K562_Hela1.03110831
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01685537
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01164260
48FLI1_27457419_Chip-Seq_LIVER_Mouse0.94983041
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93416171
50SPI1_23547873_ChIP-Seq_NB4_Human0.92224143
51HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91368880
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90930650
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88982260
54FOXP3_21729870_ChIP-Seq_TREG_Human0.86743323
55GATA3_26560356_Chip-Seq_TH1_Human0.86659680
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85106686
57RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84514874
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.79670153
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77975987
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77740871
61CTCF_20526341_ChIP-Seq_ESCs_Human0.77508254
62BCAT_22108803_ChIP-Seq_LS180_Human0.76294087
63BCL6_27268052_Chip-Seq_Bcells_Human0.75560356
64NANOG_20526341_ChIP-Seq_ESCs_Human0.72991749
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72846259
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.72330353
67P300_27268052_Chip-Seq_Bcells_Human0.70381417
68GATA2_22383799_ChIP-Seq_G1ME_Mouse0.69481659
69NFE2_27457419_Chip-Seq_LIVER_Mouse0.68518145
70MYC_19829295_ChIP-Seq_ESCs_Human0.68336834
71PRDM14_20953172_ChIP-Seq_ESCs_Human0.67670662
72GATA3_21878914_ChIP-Seq_MCF-7_Human0.67534154
73TP53_22573176_ChIP-Seq_HFKS_Human0.67045480
74STAT1_20625510_ChIP-Seq_HELA_Human0.66419543
75SMAD_19615063_ChIP-ChIP_OVARY_Human0.65104378
76TAF2_19829295_ChIP-Seq_ESCs_Human0.64801919
77FOXH1_21741376_ChIP-Seq_ESCs_Human0.62546064
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.61046384
79EGR1_23403033_ChIP-Seq_LIVER_Mouse0.59740307
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.59540643
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.59066367
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57893434
83P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.57540081
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.57498681
85NANOG_19829295_ChIP-Seq_ESCs_Human0.56409527
86SOX2_19829295_ChIP-Seq_ESCs_Human0.56409527
87RUNX1_22412390_ChIP-Seq_EML_Mouse0.55604579
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.54199112
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.53469884
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.52288140
91SPI1_23127762_ChIP-Seq_K562_Human0.52143126
92BRD4_27068464_Chip-Seq_AML-cells_Mouse0.51848002
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.51694069
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.51318819
95GATA1_19941826_ChIP-Seq_K562_Human0.51252015
96OCT4_20526341_ChIP-Seq_ESCs_Human0.50325493
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.50114693
98RAC3_21632823_ChIP-Seq_H3396_Human0.50112131
99ERG_20517297_ChIP-Seq_VCAP_Human0.50064512
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.49413622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.94231874
2MP0006082_CNS_inflammation4.07485176
3MP0000372_irregular_coat_pigmentation4.06460237
4MP0003763_abnormal_thymus_physiology3.66835211
5MP0001873_stomach_inflammation3.37713825
6MP0002148_abnormal_hypersensitivity_rea3.34120271
7MP0002277_abnormal_respiratory_mucosa2.92652761
8MP0009785_altered_susceptibility_to2.86824186
9MP0005451_abnormal_body_composition2.79495353
10MP0001800_abnormal_humoral_immune2.75916920
11MP0002723_abnormal_immune_serum2.66540495
12MP0002877_abnormal_melanocyte_morpholog2.60818591
13MP0001835_abnormal_antigen_presentation2.55820574
14MP0005000_abnormal_immune_tolerance2.53839321
15MP0010307_abnormal_tumor_latency2.38940009
16MP0002163_abnormal_gland_morphology2.38153699
17MP0005310_abnormal_salivary_gland2.36975134
18MP0002420_abnormal_adaptive_immunity2.35703915
19MP0001819_abnormal_immune_cell2.31522787
20MP0001790_abnormal_immune_system2.16970460
21MP0005387_immune_system_phenotype2.16970460
22MP0003866_abnormal_defecation2.10569929
23MP0002398_abnormal_bone_marrow2.10365548
24MP0005025_abnormal_response_to2.05528249
25MP0010155_abnormal_intestine_physiology2.04159951
26MP0002452_abnormal_antigen_presenting2.03861652
27MP0009333_abnormal_splenocyte_physiolog1.87499521
28MP0003045_fibrosis1.86617133
29MP0003806_abnormal_nucleotide_metabolis1.83240638
30MP0000685_abnormal_immune_system1.78093670
31MP0000716_abnormal_immune_system1.78065447
32MP0003786_premature_aging1.74679467
33MP0001853_heart_inflammation1.73281286
34MP0002876_abnormal_thyroid_physiology1.71030500
35MP0004147_increased_porphyrin_level1.65100136
36MP0003436_decreased_susceptibility_to1.60058685
37MP0000703_abnormal_thymus_morphology1.47098701
38MP0002429_abnormal_blood_cell1.45445122
39MP0002419_abnormal_innate_immunity1.42002343
40MP0000689_abnormal_spleen_morphology1.41246596
41MP0001919_abnormal_reproductive_system1.41154082
42MP0002405_respiratory_system_inflammati1.40371906
43MP0003448_altered_tumor_morphology1.38423820
44MP0002722_abnormal_immune_system1.37699500
45MP0005360_urolithiasis1.37337841
46MP0002933_joint_inflammation1.37224525
47MP0002254_reproductive_system_inflammat1.35409844
48MP0004381_abnormal_hair_follicle1.32961079
49MP0001845_abnormal_inflammatory_respons1.31493482
50MP0009765_abnormal_xenobiotic_induced1.28362639
51MP0001346_abnormal_lacrimal_gland1.23010052
52MP0009763_increased_sensitivity_to1.20926785
53MP0001188_hyperpigmentation1.20188158
54MP0005379_endocrine/exocrine_gland_phen1.19704371
55MP0001348_abnormal_lacrimal_gland1.13079793
56MP0008469_abnormal_protein_level1.06519330
57MP0006276_abnormal_autonomic_nervous1.00903468
58MP0000383_abnormal_hair_follicle0.97445598
59MP0005464_abnormal_platelet_physiology0.96599236
60MP0008872_abnormal_physiological_respon0.95697527
61MP0003567_abnormal_fetal_cardiomyocyte0.95622557
62MP0002166_altered_tumor_susceptibility0.94727047
63MP0000920_abnormal_myelination0.86580793
64MP0002638_abnormal_pupillary_reflex0.86484656
65MP0002234_abnormal_pharynx_morphology0.84609685
66MP0005389_reproductive_system_phenotype0.84182570
67MP0000427_abnormal_hair_cycle0.81347244
68MP0005408_hypopigmentation0.81202730
69MP0001533_abnormal_skeleton_physiology0.79886895
70MP0002693_abnormal_pancreas_physiology0.79765444
71MP0006072_abnormal_retinal_apoptosis0.79611961
72MP0000343_altered_response_to0.76562905
73MP0002168_other_aberrant_phenotype0.75905360
74MP0004145_abnormal_muscle_electrophysio0.74725723
75MP0002019_abnormal_tumor_incidence0.74573635
76MP0004947_skin_inflammation0.74184321
77MP0004270_analgesia0.72841976
78MP0000371_diluted_coat_color0.70622004
79MP0009643_abnormal_urine_homeostasis0.68442684
80MP0001663_abnormal_digestive_system0.68033651
81MP0001191_abnormal_skin_condition0.67357797
82MP0002006_tumorigenesis0.66933019
83MP0000465_gastrointestinal_hemorrhage0.65798359
84MP0003724_increased_susceptibility_to0.64339568
85MP0004043_abnormal_pH_regulation0.64287303
86MP0004742_abnormal_vestibular_system0.58964697
87MP0002095_abnormal_skin_pigmentation0.57349734
88MP0002733_abnormal_thermal_nociception0.57236499
89MP0000569_abnormal_digit_pigmentation0.56276753
90MP0005075_abnormal_melanosome_morpholog0.54054009
91MP0002090_abnormal_vision0.53768930
92MP0009745_abnormal_behavioral_response0.53211195
93MP0002751_abnormal_autonomic_nervous0.52559188
94MP0001727_abnormal_embryo_implantation0.52135812
95MP0002098_abnormal_vibrissa_morphology0.51606564
96MP0005332_abnormal_amino_acid0.51024662
97MP0005076_abnormal_cell_differentiation0.50612973
98MP0001243_abnormal_dermal_layer0.50285752
99MP0005584_abnormal_enzyme/coenzyme_acti0.49986475
100MP0010678_abnormal_skin_adnexa0.49743215

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.50570878
2Abnormality of T cell number (HP:0011839)9.21160708
3Stomatitis (HP:0010280)6.20075654
4Abnormality of T cells (HP:0002843)5.37263157
5IgA deficiency (HP:0002720)5.27416123
6Chronic diarrhea (HP:0002028)5.24491197
7IgG deficiency (HP:0004315)4.91391054
8Hypoproteinemia (HP:0003075)4.23463334
9Ureteral stenosis (HP:0000071)4.13317228
10Recurrent viral infections (HP:0004429)4.09006254
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.94358697
12Increased IgM level (HP:0003496)3.91908682
13Squamous cell carcinoma (HP:0002860)3.89363933
14Autoimmune hemolytic anemia (HP:0001890)3.80680900
15Recurrent corneal erosions (HP:0000495)3.76363063
16Ureteral obstruction (HP:0006000)3.73887379
17Abnormality of the prostate (HP:0008775)3.72046578
18Recurrent fungal infections (HP:0002841)3.65055963
19IgM deficiency (HP:0002850)3.63062898
20Cutaneous melanoma (HP:0012056)3.57724059
21Chronic mucocutaneous candidiasis (HP:0002728)3.54717358
22Recurrent cutaneous fungal infections (HP:0011370)3.54717358
23Abnormality of eosinophils (HP:0001879)3.50647973
24Arthropathy (HP:0003040)3.47146943
25Severe combined immunodeficiency (HP:0004430)3.35502836
26Entropion (HP:0000621)3.34670589
27Joint swelling (HP:0001386)3.30554685
28Autoamputation (HP:0001218)3.25880849
29Abnormality of dental color (HP:0011073)3.03744090
30Pustule (HP:0200039)3.00640259
31Chronic obstructive pulmonary disease (HP:0006510)2.98124609
32Obstructive lung disease (HP:0006536)2.98124609
33Anhidrosis (HP:0000970)2.97631248
34Type I transferrin isoform profile (HP:0003642)2.97370089
35Abnormality of oral frenula (HP:0000190)2.91534523
36Eosinophilia (HP:0001880)2.86092760
37Meningitis (HP:0001287)2.85048048
38Hepatosplenomegaly (HP:0001433)2.81604394
39Keratitis (HP:0000491)2.79710678
40Melanoma (HP:0002861)2.78555861
41Episodic fever (HP:0001954)2.77209440
42Pulmonary infiltrates (HP:0002113)2.69631138
43Paralysis (HP:0003470)2.68495461
44Thyroiditis (HP:0100646)2.65882431
45Hypoalbuminemia (HP:0003073)2.58456432
46Abnormal albumin level (HP:0012116)2.58456432
47Leukocytosis (HP:0001974)2.58257850
48Chest pain (HP:0100749)2.55459185
49Recurrent bronchitis (HP:0002837)2.55384580
50Combined immunodeficiency (HP:0005387)2.55071178
51Autoimmune thrombocytopenia (HP:0001973)2.54758311
52Hypoplasia of the thymus (HP:0000778)2.52322812
53Sensory axonal neuropathy (HP:0003390)2.50010450
54Agammaglobulinemia (HP:0004432)2.47495135
55Renal cortical cysts (HP:0000803)2.46020400
56Gangrene (HP:0100758)2.45823269
57Granulocytopenia (HP:0001913)2.44390328
58Hemoptysis (HP:0002105)2.42293169
59Zonular cataract (HP:0010920)2.41769762
60Abnormality of T cell physiology (HP:0011840)2.40290786
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40194711
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40194711
63Testicular atrophy (HP:0000029)2.34659349
64Gastrointestinal infarctions (HP:0005244)2.34439923
65Encephalitis (HP:0002383)2.29478947
66Acute hepatic failure (HP:0006554)2.25111320
67Abnormality of the pleura (HP:0002103)2.20145478
68Abnormality of midbrain morphology (HP:0002418)2.19221567
69Molar tooth sign on MRI (HP:0002419)2.19221567
70Methylmalonic acidemia (HP:0002912)2.15496294
71Abnormality of DNA repair (HP:0003254)2.15389332
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09813276
73Pulmonary fibrosis (HP:0002206)2.07955837
74Abnormal spermatogenesis (HP:0008669)2.07537189
75Short tibia (HP:0005736)2.05642531
76Radial bowing (HP:0002986)2.02432827
773-Methylglutaconic aciduria (HP:0003535)2.02214228
78Skin rash (HP:0000988)1.95764364
79Elevated erythrocyte sedimentation rate (HP:0003565)1.95632386
80Ileus (HP:0002595)1.95566432
81Porencephaly (HP:0002132)1.95015065
82Recurrent skin infections (HP:0001581)1.94417249
83Abnormality of male internal genitalia (HP:0000022)1.93758232
84Microvesicular hepatic steatosis (HP:0001414)1.92799970
85Methylmalonic aciduria (HP:0012120)1.92377452
86Orthostatic hypotension (HP:0001278)1.90364252
87Vasculitis (HP:0002633)1.90211508
88Basal cell carcinoma (HP:0002671)1.90034650
89Pulmonary embolism (HP:0002204)1.89246662
90Abnormality of cells of the lymphoid lineage (HP:0012140)1.88573020
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86611024
92Abnormal protein N-linked glycosylation (HP:0012347)1.86611024
93Abnormal protein glycosylation (HP:0012346)1.86611024
94Abnormal glycosylation (HP:0012345)1.86611024
95Increased CSF protein (HP:0002922)1.85701006
96Carpal bone hypoplasia (HP:0001498)1.84844418
97Vacuolated lymphocytes (HP:0001922)1.83457245
98Parakeratosis (HP:0001036)1.82969155
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.82877128
100Abnormal number of incisors (HP:0011064)1.81793732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK14.42648755
2MATK3.89803498
3ITK2.76331527
4MAP4K22.62364986
5KDR2.55932783
6DAPK22.43245509
7CAMKK22.34125232
8NME12.27639836
9WNK42.16253150
10TXK10.5764438
11TEC1.94090042
12PIK3CA1.91405446
13BCR1.84455535
14ADRBK21.79449677
15BMPR21.76197046
16MAPK111.72869378
17GRK71.72251260
18PRKCQ1.52021664
19LCK1.50585027
20CSK1.47333498
21GRK61.47219456
22BTK1.30470860
23SYK1.28665901
24MAP3K141.26900328
25TTK1.22254993
26CAMKK11.20516716
27MAP3K111.16410628
28TESK21.15887984
29MAP4K11.10784773
30STK391.07632758
31BUB11.05561630
32NUAK11.05248139
33IKBKB1.02467060
34RIPK11.01474385
35TLK10.98956873
36PIM10.95750097
37BRSK10.92093942
38ERBB20.89870592
39FGFR10.89715964
40MARK30.86778710
41MAPK130.85948245
42ACVR1B0.85428207
43ZAK0.84108446
44PLK20.78781848
45RIPK40.78433169
46STK100.77679979
47SRPK10.67819363
48OXSR10.65455261
49FES0.65190079
50FYN0.64305538
51VRK10.62221067
52JAK20.59187926
53LYN0.59116630
54PLK40.56595624
55TBK10.54213696
56GRK10.49935784
57PDK20.48694957
58PRKCE0.47590592
59PDK10.46871956
60MAPKAPK30.46397123
61MAP3K70.43123130
62PIM20.41327159
63BLK0.39943031
64VRK20.39797274
65IKBKE0.38705405
66PDPK10.37803148
67PINK10.37579515
68MAP3K60.37270481
69TYRO30.32508765
70LIMK10.32351618
71BRSK20.30349957
72GRK50.29913408
73ZAP700.29655831
74PRKCD0.29542244
75MAPKAPK20.29270924
76INSR0.28628885
77STK110.28425142
78PRKCA0.27007014
79BCKDK0.26396849
80PRKCB0.24809211
81EEF2K0.24601902
82HCK0.21763393
83RET0.21409323
84LRRK20.19665678
85AURKA0.19534091
86ATR0.18157279
87EIF2AK10.17947105
88CAMK2A0.17823875
89MAP2K60.16698093
90CAMK2D0.16110243
91CSNK1A10.15187495
92PRKACA0.15041914
93NLK0.13859905
94IGF1R0.12834298
95SRC0.11792119
96CAMK2G0.10515388
97DAPK10.10099842
98MAPK90.08376831
99CSNK1A1L0.06791835
100JAK30.06078183

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.34863038
2Autoimmune thyroid disease_Homo sapiens_hsa053204.41158858
3Antigen processing and presentation_Homo sapiens_hsa046123.54914620
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.54435468
5Allograft rejection_Homo sapiens_hsa053303.53013535
6Graft-versus-host disease_Homo sapiens_hsa053323.51037228
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.01280440
8Rheumatoid arthritis_Homo sapiens_hsa053232.96769935
9T cell receptor signaling pathway_Homo sapiens_hsa046602.94150538
10Hematopoietic cell lineage_Homo sapiens_hsa046402.89246963
11Type I diabetes mellitus_Homo sapiens_hsa049402.61964868
12Measles_Homo sapiens_hsa051622.35398264
13Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.16768447
14Proteasome_Homo sapiens_hsa030502.10836742
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.04211828
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99061970
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71365768
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70989466
19Salmonella infection_Homo sapiens_hsa051321.64025148
20N-Glycan biosynthesis_Homo sapiens_hsa005101.41807612
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37641366
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.33099488
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32965675
24Linoleic acid metabolism_Homo sapiens_hsa005911.10666096
25Chemokine signaling pathway_Homo sapiens_hsa040621.10228230
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09629201
27Viral myocarditis_Homo sapiens_hsa054161.08302376
28Staphylococcus aureus infection_Homo sapiens_hsa051501.08158943
29Caffeine metabolism_Homo sapiens_hsa002321.03967373
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03214066
31NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97030037
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96220879
33Prion diseases_Homo sapiens_hsa050200.96072785
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95363018
35Jak-STAT signaling pathway_Homo sapiens_hsa046300.89956210
36Shigellosis_Homo sapiens_hsa051310.85932220
37African trypanosomiasis_Homo sapiens_hsa051430.85425046
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82430303
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81026239
40Apoptosis_Homo sapiens_hsa042100.79281931
41Endocytosis_Homo sapiens_hsa041440.76730776
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.75640346
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72685369
44Asthma_Homo sapiens_hsa053100.71716131
45Oxidative phosphorylation_Homo sapiens_hsa001900.68589151
46Thyroid cancer_Homo sapiens_hsa052160.67919557
47p53 signaling pathway_Homo sapiens_hsa041150.67890102
48Fatty acid biosynthesis_Homo sapiens_hsa000610.65121379
49Nucleotide excision repair_Homo sapiens_hsa034200.63299866
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62364169
51One carbon pool by folate_Homo sapiens_hsa006700.57441358
52Influenza A_Homo sapiens_hsa051640.56692973
53HTLV-I infection_Homo sapiens_hsa051660.53680527
54Vitamin digestion and absorption_Homo sapiens_hsa049770.51156967
55RNA polymerase_Homo sapiens_hsa030200.50615742
56Notch signaling pathway_Homo sapiens_hsa043300.49562974
57Pyrimidine metabolism_Homo sapiens_hsa002400.47986221
58Homologous recombination_Homo sapiens_hsa034400.45714280
59TNF signaling pathway_Homo sapiens_hsa046680.45526254
60Tuberculosis_Homo sapiens_hsa051520.44739273
61Lysosome_Homo sapiens_hsa041420.44145055
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43117124
63Ether lipid metabolism_Homo sapiens_hsa005650.42934351
64Parkinsons disease_Homo sapiens_hsa050120.39446799
65Chemical carcinogenesis_Homo sapiens_hsa052040.39213648
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38137531
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36276538
68Herpes simplex infection_Homo sapiens_hsa051680.36212278
69Arachidonic acid metabolism_Homo sapiens_hsa005900.35831737
70Phototransduction_Homo sapiens_hsa047440.32092941
71Folate biosynthesis_Homo sapiens_hsa007900.31147913
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30628516
73Malaria_Homo sapiens_hsa051440.30189520
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29600193
75Purine metabolism_Homo sapiens_hsa002300.28979217
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.28805085
77Olfactory transduction_Homo sapiens_hsa047400.27929518
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27867748
79Osteoclast differentiation_Homo sapiens_hsa043800.26653661
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.26444978
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25282283
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24933567
83Collecting duct acid secretion_Homo sapiens_hsa049660.24753809
84Systemic lupus erythematosus_Homo sapiens_hsa053220.24067468
85Fanconi anemia pathway_Homo sapiens_hsa034600.23418808
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22727646
87Protein export_Homo sapiens_hsa030600.18078472
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18050650
89Glycerolipid metabolism_Homo sapiens_hsa005610.17087689
90Nitrogen metabolism_Homo sapiens_hsa009100.16395964
91Alzheimers disease_Homo sapiens_hsa050100.16329418
92Retinol metabolism_Homo sapiens_hsa008300.16286781
93Complement and coagulation cascades_Homo sapiens_hsa046100.15407900
94VEGF signaling pathway_Homo sapiens_hsa043700.15330011
95Starch and sucrose metabolism_Homo sapiens_hsa005000.15307813
96Leishmaniasis_Homo sapiens_hsa051400.14717188
97Selenocompound metabolism_Homo sapiens_hsa004500.12839638
98Epstein-Barr virus infection_Homo sapiens_hsa051690.12796478
99Viral carcinogenesis_Homo sapiens_hsa052030.11149108
100RNA degradation_Homo sapiens_hsa030180.10472827

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