TRAV6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to interleukin-15 (GO:0070672)7.64377569
2cellular response to interleukin-15 (GO:0071350)7.35969045
3positive regulation of gamma-delta T cell activation (GO:0046645)7.27450614
4regulation of interleukin-2 biosynthetic process (GO:0045076)7.10855251
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.83109314
6tolerance induction (GO:0002507)6.73913961
7regulation of gamma-delta T cell differentiation (GO:0045586)6.72675736
8interferon-gamma production (GO:0032609)6.63589325
9positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.61670405
10negative T cell selection (GO:0043383)6.10817817
11regulation of gamma-delta T cell activation (GO:0046643)5.89895265
12regulation of B cell receptor signaling pathway (GO:0050855)5.76676306
13negative thymic T cell selection (GO:0045060)5.72912822
14positive regulation of natural killer cell differentiation (GO:0032825)5.46009747
15regulation of regulatory T cell differentiation (GO:0045589)5.42280054
16alpha-beta T cell differentiation (GO:0046632)5.41173689
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.34906623
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.24650520
19regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.11714441
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.10301453
21negative regulation of cell killing (GO:0031342)5.05440815
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05440815
23activated T cell proliferation (GO:0050798)4.84276942
24alpha-beta T cell activation (GO:0046631)4.83847045
25T cell migration (GO:0072678)4.82934408
26antigen processing and presentation of endogenous antigen (GO:0019883)4.75447075
27thymic T cell selection (GO:0045061)4.74773369
28T cell selection (GO:0045058)4.69863600
29regulation of natural killer cell mediated immunity (GO:0002715)4.62515676
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.62515676
31positive regulation of natural killer cell mediated immunity (GO:0002717)4.56911429
32leukocyte aggregation (GO:0070486)4.56659686
33positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.46893775
34positive T cell selection (GO:0043368)4.42556523
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.35530830
36positive regulation of alpha-beta T cell proliferation (GO:0046641)4.32224754
37regulation of isotype switching to IgG isotypes (GO:0048302)4.25562205
38T cell homeostasis (GO:0043029)4.25402997
39regulation of T cell tolerance induction (GO:0002664)4.22457770
40regulation of alpha-beta T cell proliferation (GO:0046640)4.21941243
41T cell differentiation (GO:0030217)4.04723727
42regulation of interleukin-8 biosynthetic process (GO:0045414)4.03226129
43regulation of interleukin-2 production (GO:0032663)3.99580169
44T cell receptor signaling pathway (GO:0050852)3.98062604
45positive thymic T cell selection (GO:0045059)3.95899354
46mast cell activation (GO:0045576)3.90671575
47positive regulation of B cell differentiation (GO:0045579)3.90610541
48positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.89270112
49positive regulation of interleukin-2 production (GO:0032743)3.87591545
50mast cell activation involved in immune response (GO:0002279)3.85577725
51mast cell degranulation (GO:0043303)3.85577725
52positive regulation of tolerance induction (GO:0002645)3.85493106
53cytokine biosynthetic process (GO:0042089)3.85006752
54regulation of natural killer cell differentiation (GO:0032823)3.81699214
55regulation of T cell receptor signaling pathway (GO:0050856)3.73562818
56regulation of B cell differentiation (GO:0045577)3.71589490
57regulation of cytokine production involved in inflammatory response (GO:1900015)3.65914325
58regulation of leukocyte mediated cytotoxicity (GO:0001910)3.64635029
59antigen receptor-mediated signaling pathway (GO:0050851)3.62920645
60positive regulation of cell killing (GO:0031343)3.54352808
61regulation of tolerance induction (GO:0002643)3.52772774
62negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.52745592
63Peyers patch development (GO:0048541)3.47479931
64mucosal-associated lymphoid tissue development (GO:0048537)3.47479931
65T cell proliferation (GO:0042098)3.46895378
66negative regulation of execution phase of apoptosis (GO:1900118)3.46512395
67regulation of defense response to virus by virus (GO:0050690)3.45796280
68T cell activation (GO:0042110)3.42849492
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.39948651
70T cell costimulation (GO:0031295)3.39776306
71negative regulation of T cell mediated immunity (GO:0002710)3.37292416
72T cell mediated immunity (GO:0002456)3.35542288
73positive regulation of humoral immune response (GO:0002922)3.35449041
74regulation of interleukin-6 biosynthetic process (GO:0045408)3.35230348
75lymphocyte costimulation (GO:0031294)3.35121224
76regulation of cell killing (GO:0031341)3.33986929
77chemokine-mediated signaling pathway (GO:0070098)3.30556244
78T-helper cell differentiation (GO:0042093)3.30364325
79CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.30364325
80CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.30335644
81mature B cell differentiation (GO:0002335)3.28748901
82myeloid dendritic cell differentiation (GO:0043011)3.28054407
83positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.27981087
84positive regulation of granulocyte differentiation (GO:0030854)3.24028398
85cytokine metabolic process (GO:0042107)3.23504596
86myeloid dendritic cell activation (GO:0001773)3.18649964
87negative regulation of lymphocyte mediated immunity (GO:0002707)3.16011274
88regulation of interleukin-12 biosynthetic process (GO:0045075)3.15209036
89alpha-beta T cell differentiation involved in immune response (GO:0002293)3.12831403
90alpha-beta T cell activation involved in immune response (GO:0002287)3.12831403
91T cell differentiation involved in immune response (GO:0002292)3.12831403
92dendritic cell chemotaxis (GO:0002407)3.09618149
93positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.05991566
94positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05207173
95regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.02468458
96lymphocyte differentiation (GO:0030098)3.01598990
97regulation of response to interferon-gamma (GO:0060330)3.01405680
98positive regulation of calcium-mediated signaling (GO:0050850)3.01320740
99negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.00442136
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.00404633

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.81969354
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.99407773
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.29948934
4IRF8_22096565_ChIP-ChIP_GC-B_Human5.41641486
5RUNX_20019798_ChIP-Seq_JUKART_Human3.88138136
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.64176695
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.33285875
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.32052683
9MYB_26560356_Chip-Seq_TH2_Human3.05993900
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99747837
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.75981442
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.52317289
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47756125
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40540049
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35834174
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32161496
17MYB_26560356_Chip-Seq_TH1_Human2.30649176
18GATA3_27048872_Chip-Seq_THYMUS_Human2.18841778
19MAF_26560356_Chip-Seq_TH1_Human2.07639099
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.01384116
21UTX_26944678_Chip-Seq_JUKART_Human1.93283095
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90023122
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.86232165
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.82080240
25MAF_26560356_Chip-Seq_TH2_Human1.81762862
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79627713
27SPI1_23547873_ChIP-Seq_NB4_Human1.76853723
28GATA3_26560356_Chip-Seq_TH2_Human1.75691549
29RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.70558274
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68732077
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64031587
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61603475
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59970861
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55850907
35CIITA_25753668_ChIP-Seq_RAJI_Human1.52752673
36SCL_19346495_ChIP-Seq_HPC-7_Human1.44374370
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.43318749
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42199160
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38330726
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34399512
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.31083869
42FOXP3_21729870_ChIP-Seq_TREG_Human1.29465409
43MYC_22102868_ChIP-Seq_BL_Human1.28947034
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26860399
45SPI1_23127762_ChIP-Seq_K562_Human1.23815451
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20914065
47VDR_22108803_ChIP-Seq_LS180_Human1.20898969
48GATA1_22025678_ChIP-Seq_K562_Human1.20258130
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17629351
50VDR_23849224_ChIP-Seq_CD4+_Human1.16615419
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14560734
52VDR_21846776_ChIP-Seq_THP-1_Human1.12786236
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11038637
54VDR_24787735_ChIP-Seq_THP-1_Human1.10074967
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07661519
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03993786
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97816343
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96657748
59PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95953127
60YY1_21170310_ChIP-Seq_MESCs_Mouse0.93744232
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92316301
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90422172
63VDR_24763502_ChIP-Seq_THP-1_Human0.89877728
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89574389
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89008116
66STAT1_20625510_ChIP-Seq_HELA_Human0.88857084
67PU_27001747_Chip-Seq_BMDM_Mouse0.88076897
68KDM2B_26808549_Chip-Seq_DND41_Human0.86834098
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85784377
70GATA3_26560356_Chip-Seq_TH1_Human0.82508401
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82446684
72HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82403805
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82368340
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82250842
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81741718
76GABP_17652178_ChIP-ChIP_JURKAT_Human0.81671226
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80064126
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79011752
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78471062
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78028955
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77693779
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75963221
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.72920834
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71940248
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70496642
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.69052955
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68661605
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.68306811
89TCF7_22412390_ChIP-Seq_EML_Mouse0.67190971
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.66943799
91SMRT_27268052_Chip-Seq_Bcells_Human0.66629606
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.65769101
93IRF1_19129219_ChIP-ChIP_H3396_Human0.65756285
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.65738103
95EST1_17652178_ChIP-ChIP_JURKAT_Human0.65688239
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65423202
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62987142
98FLI1_21867929_ChIP-Seq_CD8_Mouse0.62718157
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.62716260
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.60730332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.00477028
2MP0001873_stomach_inflammation4.41395594
3MP0003763_abnormal_thymus_physiology4.35081520
4MP0001790_abnormal_immune_system4.00059421
5MP0005387_immune_system_phenotype4.00059421
6MP0001835_abnormal_antigen_presentation3.74774973
7MP0001800_abnormal_humoral_immune3.51718749
8MP0003866_abnormal_defecation3.38335948
9MP0005000_abnormal_immune_tolerance2.94133985
10MP0002723_abnormal_immune_serum2.90074985
11MP0009785_altered_susceptibility_to2.81199101
12MP0009333_abnormal_splenocyte_physiolog2.80129936
13MP0000465_gastrointestinal_hemorrhage2.77510906
14MP0002420_abnormal_adaptive_immunity2.68690507
15MP0001819_abnormal_immune_cell2.63836633
16MP0000685_abnormal_immune_system2.59525366
17MP0005025_abnormal_response_to2.57788978
18MP0010155_abnormal_intestine_physiology2.56835833
19MP0002452_abnormal_antigen_presenting2.55600823
20MP0003436_decreased_susceptibility_to2.45192539
21MP0002405_respiratory_system_inflammati2.37843251
22MP0009384_cardiac_valve_regurgitation2.35496458
23MP0002398_abnormal_bone_marrow2.29146902
24MP0002148_abnormal_hypersensitivity_rea2.27618952
25MP0000703_abnormal_thymus_morphology2.26158117
26MP0002166_altered_tumor_susceptibility2.20754564
27MP0000716_abnormal_immune_system2.06228936
28MP0003724_increased_susceptibility_to2.02373122
29MP0000689_abnormal_spleen_morphology1.98964738
30MP0001845_abnormal_inflammatory_respons1.94701237
31MP0006082_CNS_inflammation1.87052641
32MP0002722_abnormal_immune_system1.86969204
33MP0002419_abnormal_innate_immunity1.86184005
34MP0001348_abnormal_lacrimal_gland1.77313997
35MP0004381_abnormal_hair_follicle1.70663602
36MP0002933_joint_inflammation1.69389914
37MP0002429_abnormal_blood_cell1.62316401
38MP0005075_abnormal_melanosome_morpholog1.56827028
39MP0002006_tumorigenesis1.53559790
40MP0002138_abnormal_hepatobiliary_system1.52941709
41MP0004947_skin_inflammation1.49568419
42MP0003303_peritoneal_inflammation1.45671356
43MP0005310_abnormal_salivary_gland1.39859633
44MP0002396_abnormal_hematopoietic_system1.34143696
45MP0001663_abnormal_digestive_system1.33911648
46MP0003172_abnormal_lysosome_physiology1.26294975
47MP0003045_fibrosis1.25483248
48MP0000490_abnormal_crypts_of1.23741093
49MP0001851_eye_inflammation1.21200918
50MP0002277_abnormal_respiratory_mucosa1.16835719
51MP0008469_abnormal_protein_level1.16216592
52MP0003300_gastrointestinal_ulcer1.15094253
53MP0002163_abnormal_gland_morphology0.99056218
54MP0003183_abnormal_peptide_metabolism0.93958598
55MP0005670_abnormal_white_adipose0.91778576
56MP0001533_abnormal_skeleton_physiology0.89775914
57MP0008057_abnormal_DNA_replication0.88431790
58MP0009764_decreased_sensitivity_to0.87813031
59MP0005381_digestive/alimentary_phenotyp0.86620960
60MP0005464_abnormal_platelet_physiology0.80103520
61MP0001853_heart_inflammation0.78193760
62MP0002693_abnormal_pancreas_physiology0.76621867
63MP0003448_altered_tumor_morphology0.76281533
64MP0005379_endocrine/exocrine_gland_phen0.70877096
65MP0008961_abnormal_basal_metabolism0.69920496
66MP0005166_decreased_susceptibility_to0.69126743
67MP0000858_altered_metastatic_potential0.68598943
68MP0008877_abnormal_DNA_methylation0.63151570
69MP0003329_amyloid_beta_deposits0.61096445
70MP0000604_amyloidosis0.60654222
71MP0005360_urolithiasis0.60164825
72MP0002009_preneoplasia0.59792945
73MP0002019_abnormal_tumor_incidence0.59765947
74MP0003011_delayed_dark_adaptation0.54452529
75MP0004883_abnormal_blood_vessel0.52392040
76MP0001958_emphysema0.52132209
77MP0009763_increased_sensitivity_to0.51328393
78MP0006072_abnormal_retinal_apoptosis0.48910509
79MP0003191_abnormal_cellular_cholesterol0.48105035
80MP0005451_abnormal_body_composition0.46684261
81MP0002132_abnormal_respiratory_system0.46625968
82MP0000609_abnormal_liver_physiology0.46624973
83MP0004142_abnormal_muscle_tone0.46202048
84MP0002136_abnormal_kidney_physiology0.45592393
85MP0004808_abnormal_hematopoietic_stem0.44363667
86MP0009643_abnormal_urine_homeostasis0.44216595
87MP0008569_lethality_at_weaning0.41525204
88MP0005084_abnormal_gallbladder_morpholo0.41352955
89MP0003795_abnormal_bone_structure0.41179760
90MP0003252_abnormal_bile_duct0.39924795
91MP0001765_abnormal_ion_homeostasis0.38367087
92MP0005535_abnormal_body_temperature0.34736916
93MP0002998_abnormal_bone_remodeling0.34011409
94MP0001919_abnormal_reproductive_system0.33616017
95MP0001346_abnormal_lacrimal_gland0.33410720
96MP0005645_abnormal_hypothalamus_physiol0.32566387
97MP0003828_pulmonary_edema0.31072145
98MP0009765_abnormal_xenobiotic_induced0.30789030
99MP0000313_abnormal_cell_death0.30773478
100MP0002168_other_aberrant_phenotype0.30321573

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.34617518
2T lymphocytopenia (HP:0005403)7.19524548
3Elevated erythrocyte sedimentation rate (HP:0003565)6.80501043
4Recurrent cutaneous fungal infections (HP:0011370)6.75046229
5Chronic mucocutaneous candidiasis (HP:0002728)6.75046229
6Abnormality of T cell number (HP:0011839)6.54384005
7Increased IgM level (HP:0003496)5.59504068
8Chronic diarrhea (HP:0002028)5.59349179
9Recurrent fungal infections (HP:0002841)5.50980579
10IgG deficiency (HP:0004315)5.10325131
11Absent rod-and cone-mediated responses on ERG (HP:0007688)5.06400018
12Abnormality of T cells (HP:0002843)5.04504437
13Dyschromatopsia (HP:0007641)4.87423781
14Myositis (HP:0100614)4.37520490
15Autoimmune hemolytic anemia (HP:0001890)4.07429473
16Neonatal hypoglycemia (HP:0001998)4.05082191
17Optic neuritis (HP:0100653)3.94583322
18Retrobulbar optic neuritis (HP:0100654)3.94583322
19Recurrent skin infections (HP:0001581)3.89749779
20Cheilitis (HP:0100825)3.78989245
21Orchitis (HP:0100796)3.70057857
22Hemoptysis (HP:0002105)3.63145610
23Encephalitis (HP:0002383)3.57486097
24Vitreoretinal degeneration (HP:0000655)3.50629281
25IgA deficiency (HP:0002720)3.44384720
26Recurrent viral infections (HP:0004429)3.39229438
27Joint swelling (HP:0001386)3.36639642
28Severe combined immunodeficiency (HP:0004430)3.31737800
29Abnormality of T cell physiology (HP:0011840)3.24989650
30Recurrent bronchitis (HP:0002837)3.24884908
31Eczematoid dermatitis (HP:0000976)3.21109456
32Abnormal rod and cone electroretinograms (HP:0008323)3.19659928
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.07915991
34Lymphopenia (HP:0001888)3.02063527
35Acute hepatic failure (HP:0006554)2.95316678
36Meningitis (HP:0001287)2.91285468
37Hypoproteinemia (HP:0003075)2.90610261
38Keratoconjunctivitis sicca (HP:0001097)2.88182657
39Pustule (HP:0200039)2.84706171
40Pigmentary retinal degeneration (HP:0001146)2.84541559
41Abnormality of macrophages (HP:0004311)2.83469854
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.82235028
43Abnormality of the fingertips (HP:0001211)2.81123793
44Cellular immunodeficiency (HP:0005374)2.80762397
45Keratoconjunctivitis (HP:0001096)2.80312568
46Hypergammaglobulinemia (HP:0010702)2.76717920
47Recurrent bacterial skin infections (HP:0005406)2.70928082
48Pulmonary infiltrates (HP:0002113)2.69523531
49IgM deficiency (HP:0002850)2.65725654
50Alveolar cell carcinoma (HP:0006519)2.65014164
51Hypochromic microcytic anemia (HP:0004840)2.61609813
52Recurrent abscess formation (HP:0002722)2.57615452
53Combined immunodeficiency (HP:0005387)2.50568885
54Pancytopenia (HP:0001876)2.49709616
55Lymphoma (HP:0002665)2.47094696
56Vasculitis (HP:0002633)2.46072362
57Hypoplasia of the thymus (HP:0000778)2.43005455
58Gastrointestinal infarctions (HP:0005244)2.37542393
59Hypochromic anemia (HP:0001931)2.36399521
60Neoplasm of the tracheobronchial system (HP:0100552)2.34039809
61Skin rash (HP:0000988)2.30320546
62Colon cancer (HP:0003003)2.29367055
63Aplastic anemia (HP:0001915)2.25154845
64Mediastinal lymphadenopathy (HP:0100721)2.24367418
65Leukocytosis (HP:0001974)2.20714083
66Abnormality of eosinophils (HP:0001879)2.20065075
67Panhypogammaglobulinemia (HP:0003139)2.19849865
683-Methylglutaconic aciduria (HP:0003535)2.16007339
69Abnormality of the endocardium (HP:0004306)2.12300736
70Basal cell carcinoma (HP:0002671)2.06639417
71Inflammation of the large intestine (HP:0002037)2.05455251
72Hepatosplenomegaly (HP:0001433)2.03549579
73Thyroiditis (HP:0100646)2.02664100
74Micronodular cirrhosis (HP:0001413)1.94033109
75Microcytic anemia (HP:0001935)1.91940431
76Gastrointestinal inflammation (HP:0004386)1.91930003
77Gangrene (HP:0100758)1.89943477
78Papilledema (HP:0001085)1.89478914
79Agammaglobulinemia (HP:0004432)1.85361496
80Bronchitis (HP:0012387)1.81704453
81Mutism (HP:0002300)1.81620223
82Anorexia (HP:0002039)1.80221679
83Obstructive lung disease (HP:0006536)1.78795696
84Chronic obstructive pulmonary disease (HP:0006510)1.78795696
85Hepatitis (HP:0012115)1.78535845
86Chronic otitis media (HP:0000389)1.78231120
87Abolished electroretinogram (ERG) (HP:0000550)1.78149865
88B lymphocytopenia (HP:0010976)1.72933084
89Granulocytopenia (HP:0001913)1.71740958
90Amaurosis fugax (HP:0100576)1.71392383
91Pulmonary embolism (HP:0002204)1.71349307
92Abnormality of B cell number (HP:0010975)1.71250382
93Slow saccadic eye movements (HP:0000514)1.71241199
94Scanning speech (HP:0002168)1.70474894
95Stomach cancer (HP:0012126)1.70370284
96Palpitations (HP:0001962)1.70266294
97Progressive inability to walk (HP:0002505)1.66766347
98Resting tremor (HP:0002322)1.66586827
99Abnormality of the pleura (HP:0002103)1.65766861
100Chest pain (HP:0100749)1.65241189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.60771153
2MAP4K14.45454190
3ITK2.97583130
4FES2.81706822
5TYK22.71559726
6TEC2.38285370
7TAOK32.27084213
8SIK32.26606874
9TYRO32.26168003
10BTK2.24746501
11RIPK42.13420019
12TAF12.02040613
13CSK1.86485036
14HCK1.78625196
15LCK1.57024592
16GRK61.55915107
17SYK1.53807957
18GRK71.47617219
19IKBKE1.47002238
20NLK1.46597550
21MOS1.44655965
22CLK11.41709380
23MAP3K121.33255308
24MAP3K131.31334616
25LYN1.30533199
26JAK31.23151119
27EPHB11.22971542
28JAK21.22905911
29PASK1.19575639
30MAP2K61.12527405
31IRAK41.11965921
32PRKCQ1.11536205
33VRK21.10132738
34ZAP701.09882891
35FGFR41.06758840
36KDR1.06262169
37IKBKB1.03879475
38PTK61.01506167
39STK100.99967490
40JAK10.97917774
41CAMKK20.96613765
42MST40.96247702
43TGFBR20.91196372
44MAP3K30.86892851
45MAP2K30.83479069
46TBK10.81362130
47MARK30.68890172
48BCR0.65787695
49PDK10.65549760
50CSF1R0.64470384
51HIPK20.63512458
52NTRK20.63010205
53TRIM280.62179038
54TNK20.62135782
55FYN0.58813386
56GRK50.58614849
57FGFR30.58504707
58SIK20.56224776
59MAP3K140.56146655
60MAP3K110.55352183
61CAMKK10.54642047
62VRK10.54407338
63CDK40.52816973
64PDGFRB0.52243934
65PRKCH0.51853234
66ADRBK20.50021009
67KIT0.49071991
68PTK2B0.47928234
69MAPK110.47175569
70SMG10.46309555
71IGF1R0.44705936
72NUAK10.43678894
73NEK60.42691446
74IRAK10.42089964
75BLK0.38944575
76PRPF4B0.38506878
77INSR0.36974993
78ERN10.36223525
79MAPKAPK20.35287782
80KSR20.34913659
81MAP3K10.34589359
82EPHB20.30195372
83SCYL20.27924436
84CCNB10.27121422
85TRPM70.27113978
86FGR0.26570203
87EPHA30.25821340
88GRK10.24665956
89STK380.20434383
90MAP3K80.19989017
91YES10.18828400
92TAOK10.16434426
93PIM10.16288843
94TAOK20.16075863
95CHUK0.15792934
96MAPK120.15605987
97PRKACG0.14938439
98MAPK30.14886583
99MARK20.12332692
100PDK20.10897200

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.55255679
2T cell receptor signaling pathway_Homo sapiens_hsa046604.31302013
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.86028745
4Measles_Homo sapiens_hsa051623.19351210
5Allograft rejection_Homo sapiens_hsa053303.12067650
6Autoimmune thyroid disease_Homo sapiens_hsa053203.12060076
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.99389741
8Graft-versus-host disease_Homo sapiens_hsa053322.89291167
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.79281399
10Hematopoietic cell lineage_Homo sapiens_hsa046402.72262132
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.14921159
12Type I diabetes mellitus_Homo sapiens_hsa049402.14528695
13Antigen processing and presentation_Homo sapiens_hsa046122.13655599
14Jak-STAT signaling pathway_Homo sapiens_hsa046302.07512712
15Osteoclast differentiation_Homo sapiens_hsa043802.05683642
16Viral myocarditis_Homo sapiens_hsa054161.99433563
17B cell receptor signaling pathway_Homo sapiens_hsa046621.83407224
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.69227879
19Chemokine signaling pathway_Homo sapiens_hsa040621.62587305
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60005389
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57874921
22Non-homologous end-joining_Homo sapiens_hsa034501.44881969
23Hepatitis B_Homo sapiens_hsa051611.25319870
24RNA polymerase_Homo sapiens_hsa030201.23621150
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21353657
26Leishmaniasis_Homo sapiens_hsa051401.18554063
27Acute myeloid leukemia_Homo sapiens_hsa052211.18456114
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.18006859
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15015128
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11054478
31Herpes simplex infection_Homo sapiens_hsa051681.08728360
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08581388
33HTLV-I infection_Homo sapiens_hsa051661.06341301
34Protein export_Homo sapiens_hsa030601.05035893
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02551613
36Malaria_Homo sapiens_hsa051441.01089592
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00652510
38Platelet activation_Homo sapiens_hsa046110.95559925
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93552027
40Shigellosis_Homo sapiens_hsa051310.89257370
41Proteasome_Homo sapiens_hsa030500.87550792
42Epstein-Barr virus infection_Homo sapiens_hsa051690.86126153
43Influenza A_Homo sapiens_hsa051640.81628022
44Staphylococcus aureus infection_Homo sapiens_hsa051500.77887900
45TNF signaling pathway_Homo sapiens_hsa046680.77388105
46Asthma_Homo sapiens_hsa053100.76225111
47Regulation of autophagy_Homo sapiens_hsa041400.74975445
48Rheumatoid arthritis_Homo sapiens_hsa053230.71718940
49Apoptosis_Homo sapiens_hsa042100.71374900
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67482955
51Tuberculosis_Homo sapiens_hsa051520.66341128
52Viral carcinogenesis_Homo sapiens_hsa052030.65757949
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65329079
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64303629
55Toxoplasmosis_Homo sapiens_hsa051450.63534601
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.57575528
57African trypanosomiasis_Homo sapiens_hsa051430.56502722
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55373978
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55045966
60Legionellosis_Homo sapiens_hsa051340.54620589
61Hepatitis C_Homo sapiens_hsa051600.52261009
62VEGF signaling pathway_Homo sapiens_hsa043700.51717568
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49421973
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48551968
65HIF-1 signaling pathway_Homo sapiens_hsa040660.45228414
66MAPK signaling pathway_Homo sapiens_hsa040100.43046833
67Prolactin signaling pathway_Homo sapiens_hsa049170.42473570
68Colorectal cancer_Homo sapiens_hsa052100.42342772
69Caffeine metabolism_Homo sapiens_hsa002320.41805208
70Endocytosis_Homo sapiens_hsa041440.40970956
71RNA degradation_Homo sapiens_hsa030180.40103536
72Linoleic acid metabolism_Homo sapiens_hsa005910.39505091
73Non-small cell lung cancer_Homo sapiens_hsa052230.39329835
74mTOR signaling pathway_Homo sapiens_hsa041500.37880558
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37237353
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32618124
77FoxO signaling pathway_Homo sapiens_hsa040680.32216921
78Circadian rhythm_Homo sapiens_hsa047100.29360973
79Salmonella infection_Homo sapiens_hsa051320.28841760
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27884800
81Endometrial cancer_Homo sapiens_hsa052130.25906536
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.24047988
83Thyroid cancer_Homo sapiens_hsa052160.23578174
84Oxytocin signaling pathway_Homo sapiens_hsa049210.23154584
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22998931
86Pancreatic cancer_Homo sapiens_hsa052120.20680019
87Pertussis_Homo sapiens_hsa051330.20125889
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.19657650
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19632259
90Pyrimidine metabolism_Homo sapiens_hsa002400.17780327
91Insulin resistance_Homo sapiens_hsa049310.16910914
92Phagosome_Homo sapiens_hsa041450.15681793
93Prion diseases_Homo sapiens_hsa050200.13314125
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12701226
95Chronic myeloid leukemia_Homo sapiens_hsa052200.12560493
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10830764
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.09515665
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09321622
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09226740
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09194653

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