TRAV8-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-8 secretion (GO:2000484)9.92712023
2positive thymic T cell selection (GO:0045059)9.20349677
3negative thymic T cell selection (GO:0045060)8.73246974
4negative T cell selection (GO:0043383)8.64754882
5thymic T cell selection (GO:0045061)8.35822338
6positive regulation of gamma-delta T cell activation (GO:0046645)8.25666261
7positive T cell selection (GO:0043368)7.88738131
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.54905857
9T cell selection (GO:0045058)7.43204694
10regulation of gamma-delta T cell differentiation (GO:0045586)7.19527880
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.02487903
12sequestering of actin monomers (GO:0042989)6.82604019
13T cell receptor signaling pathway (GO:0050852)6.44797558
14regulation of gamma-delta T cell activation (GO:0046643)6.40340649
15heterotypic cell-cell adhesion (GO:0034113)6.33579514
16T cell costimulation (GO:0031295)6.29732198
17lymphocyte costimulation (GO:0031294)6.17190267
18regulation of T cell tolerance induction (GO:0002664)6.09399971
19regulation of interleukin-8 secretion (GO:2000482)5.87523600
20membrane raft organization (GO:0031579)5.81954118
21negative regulation of cell killing (GO:0031342)5.68095248
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.68095248
23interferon-gamma production (GO:0032609)5.45744323
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44842388
25regulation of isotype switching to IgG isotypes (GO:0048302)5.41128927
26response to interleukin-15 (GO:0070672)5.37747618
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.36097512
28regulation of interleukin-2 biosynthetic process (GO:0045076)5.28344677
29cellular response to interleukin-15 (GO:0071350)5.25075096
30antigen receptor-mediated signaling pathway (GO:0050851)5.12067251
31leukocyte aggregation (GO:0070486)5.09753505
32localization within membrane (GO:0051668)5.08617370
33cytolysis (GO:0019835)5.01203463
34positive regulation of tolerance induction (GO:0002645)4.97689433
35negative regulation of interleukin-12 production (GO:0032695)4.86270704
36T cell migration (GO:0072678)4.77460490
37morphogenesis of an endothelium (GO:0003159)4.75104935
38endothelial tube morphogenesis (GO:0061154)4.75104935
39negative regulation of phagocytosis (GO:0050765)4.63055996
40positive regulation of humoral immune response (GO:0002922)4.62749120
41regulation of T cell receptor signaling pathway (GO:0050856)4.62514609
42regulation of defense response to virus by virus (GO:0050690)4.61160748
43response to type I interferon (GO:0034340)4.61118253
44negative regulation of T cell apoptotic process (GO:0070233)4.59047712
45cellular response to type I interferon (GO:0071357)4.54787840
46type I interferon signaling pathway (GO:0060337)4.54787840
47natural killer cell activation (GO:0030101)4.53184876
48regulation of alpha-beta T cell proliferation (GO:0046640)4.37863141
49positive regulation of interferon-gamma production (GO:0032729)4.30607202
50regulation of tolerance induction (GO:0002643)4.28824915
51positive regulation of interleukin-2 production (GO:0032743)4.26690133
52regulation of B cell differentiation (GO:0045577)4.26206677
53positive regulation of alpha-beta T cell proliferation (GO:0046641)4.25300228
54mast cell activation (GO:0045576)4.21666120
55cell wall macromolecule catabolic process (GO:0016998)4.18781762
56regulation of activation of Janus kinase activity (GO:0010533)4.16794524
57negative regulation of leukocyte mediated immunity (GO:0002704)4.15654025
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10141706
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10141706
60positive regulation of granulocyte differentiation (GO:0030854)4.09406710
61negative regulation of lymphocyte mediated immunity (GO:0002707)4.06524394
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.03942136
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.03687544
64regulation of type I interferon-mediated signaling pathway (GO:0060338)4.01570153
65mast cell activation involved in immune response (GO:0002279)3.93553462
66mast cell degranulation (GO:0043303)3.93553462
67regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.91072110
68regulation of response to interferon-gamma (GO:0060330)3.87206666
69T cell activation (GO:0042110)3.80963175
70positive regulation of interleukin-4 production (GO:0032753)3.77468446
71positive regulation of B cell differentiation (GO:0045579)3.76424283
72cytokine biosynthetic process (GO:0042089)3.74816329
73positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.73669302
74positive regulation of interleukin-17 production (GO:0032740)3.69856438
75T cell differentiation (GO:0030217)3.67900599
76regulation of interferon-gamma production (GO:0032649)3.65814905
77negative regulation of B cell mediated immunity (GO:0002713)3.62690719
78negative regulation of immunoglobulin mediated immune response (GO:0002890)3.62690719
79positive regulation of natural killer cell differentiation (GO:0032825)3.62166069
80regulation of interleukin-12 biosynthetic process (GO:0045075)3.60537727
81positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.59803888
82regulation of interleukin-4 production (GO:0032673)3.59252359
83regulation of regulatory T cell differentiation (GO:0045589)3.57328242
84positive regulation of natural killer cell mediated immunity (GO:0002717)3.56708945
85positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.56708945
86immunoglobulin mediated immune response (GO:0016064)3.55449574
87regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.49046396
88regulation of natural killer cell mediated immunity (GO:0002715)3.49046396
89cell wall macromolecule metabolic process (GO:0044036)3.47670622
90regulation of leukocyte mediated cytotoxicity (GO:0001910)3.47147831
91immune response-activating cell surface receptor signaling pathway (GO:0002429)3.45427950
92positive regulation of calcium-mediated signaling (GO:0050850)3.45014825
93activated T cell proliferation (GO:0050798)3.42900691
94regulation of T cell mediated cytotoxicity (GO:0001914)3.37769456
95respiratory burst (GO:0045730)3.36312680
96interferon-gamma-mediated signaling pathway (GO:0060333)3.35307612
97regulation of alpha-beta T cell activation (GO:0046634)3.34181403
98cellular defense response (GO:0006968)3.33843485
99negative regulation of T cell mediated immunity (GO:0002710)3.30898387
100antigen processing and presentation of endogenous antigen (GO:0019883)3.30348847
101positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27965839
102B cell receptor signaling pathway (GO:0050853)3.27800663
103positive regulation of T cell activation (GO:0050870)3.27696874
104negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.26731676
105signal complex assembly (GO:0007172)3.21970672
106regulation of T cell activation (GO:0050863)3.21384532
107Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19611427
108positive regulation of alpha-beta T cell activation (GO:0046635)3.19195752
109T cell lineage commitment (GO:0002360)3.18960275
110tolerance induction (GO:0002507)3.18849546
111regulation of hypersensitivity (GO:0002883)3.18191906
112regulation of B cell receptor signaling pathway (GO:0050855)3.17567816
113negative regulation of lymphocyte apoptotic process (GO:0070229)3.17126215
114B cell mediated immunity (GO:0019724)3.16290309
115T cell homeostasis (GO:0043029)3.15557435
116positive regulation of uterine smooth muscle contraction (GO:0070474)3.12885865
117antigen processing and presentation via MHC class Ib (GO:0002475)3.12762863
118regulation of interleukin-2 production (GO:0032663)3.10285792
119negative regulation of stress fiber assembly (GO:0051497)3.09879422
120positive regulation of cell killing (GO:0031343)3.09469825
121cellular response to interleukin-4 (GO:0071353)3.09393927
122NIK/NF-kappaB signaling (GO:0038061)3.08310103
123megakaryocyte development (GO:0035855)3.07602425
124positive regulation of lamellipodium assembly (GO:0010592)3.06617443
125regulation of cell killing (GO:0031341)3.02859677
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.99555802
127regulation of T cell apoptotic process (GO:0070232)2.98477338
1283-UTR-mediated mRNA stabilization (GO:0070935)2.98428537
129cellular extravasation (GO:0045123)2.97561137
130lymphocyte migration (GO:0072676)2.97176213
131alpha-beta T cell differentiation (GO:0046632)2.96828065
132positive regulation of lymphocyte activation (GO:0051251)2.96587401
133dendritic cell chemotaxis (GO:0002407)2.95239139
134negative regulation of type 2 immune response (GO:0002829)2.91102883
135mannose metabolic process (GO:0006013)2.89167440
136T-helper cell differentiation (GO:0042093)2.87949554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.39086351
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.36067494
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.53715869
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.65573942
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.54892130
6RUNX_20019798_ChIP-Seq_JUKART_Human4.04121444
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.87629622
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.80006829
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.59123231
10MAF_26560356_Chip-Seq_TH1_Human3.41258789
11MYC_22102868_ChIP-Seq_BL_Human3.41034178
12MYB_26560356_Chip-Seq_TH2_Human3.25647525
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.20915289
14UTX_26944678_Chip-Seq_JUKART_Human3.09426167
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.98179748
16MYB_26560356_Chip-Seq_TH1_Human2.74738064
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71294278
18MAF_26560356_Chip-Seq_TH2_Human2.42620454
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30436159
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29748581
21GATA3_27048872_Chip-Seq_THYMUS_Human2.25547322
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.16698231
23E2F7_22180533_ChIP-Seq_HELA_Human2.01681839
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.99464780
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96703204
26VDR_21846776_ChIP-Seq_THP-1_Human1.82203989
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82116799
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80864664
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78967949
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77019710
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.70502101
32TCF7_22412390_ChIP-Seq_EML_Mouse1.68457767
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64595165
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60881211
35KDM2B_26808549_Chip-Seq_DND41_Human1.59068876
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.56465307
37SPI1_23127762_ChIP-Seq_K562_Human1.53876970
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.52853278
39SCL_19346495_ChIP-Seq_HPC-7_Human1.49647453
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46711252
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46603715
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44653668
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42734875
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41758875
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40494183
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40349559
47SPI1_23547873_ChIP-Seq_NB4_Human1.38491984
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38431637
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.36556036
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36544826
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.35291241
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33190949
53AR_21572438_ChIP-Seq_LNCaP_Human1.32158514
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29318236
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29318236
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29318236
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21015550
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19464782
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19025372
60SPI1_20517297_ChIP-Seq_HL60_Human1.17405060
61VDR_24763502_ChIP-Seq_THP-1_Human1.15618876
62PU_27001747_Chip-Seq_BMDM_Mouse1.15515909
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13136366
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12670749
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11351403
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09946583
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09563205
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.05102873
69GATA3_26560356_Chip-Seq_TH2_Human1.03238080
70VDR_23849224_ChIP-Seq_CD4+_Human1.03041492
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01769581
72GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99257942
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98758079
74GATA1_19941826_ChIP-Seq_K562_Human0.95227626
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94390595
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94380665
77VDR_24787735_ChIP-Seq_THP-1_Human0.89976350
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89556309
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.89025872
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88808081
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88662431
82CIITA_25753668_ChIP-Seq_RAJI_Human0.88624994
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88332339
84GATA3_26560356_Chip-Seq_TH1_Human0.88160811
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86887891
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85907398
87BCL6_27268052_Chip-Seq_Bcells_Human0.85846602
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85312659
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84939169
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83190763
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82554735
92FOXP3_21729870_ChIP-Seq_TREG_Human0.82394913
93ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82023117
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77354050
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76532055
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74960654
97IRF1_19129219_ChIP-ChIP_H3396_Human0.73897124
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73413519
99SA1_27219007_Chip-Seq_Bcells_Human0.72813960
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72257859
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70707609
102GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70034200
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68989794
104LXR_22292898_ChIP-Seq_THP-1_Human0.68684892
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68565840
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.67107553
107CTCF_26484167_Chip-Seq_Bcells_Mouse0.66979146
108P68_20966046_ChIP-Seq_HELA_Human0.66841692
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.66692299
110ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66605616
111RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.66485430
112SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.66007239
113RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65572568
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.64522474
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62527198
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.61609772
117TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.60183262
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.59168257
119GATA2_19941826_ChIP-Seq_K562_Human0.58874167
120ERG_20887958_ChIP-Seq_HPC-7_Mouse0.58765364
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58397166
122ETS1_21867929_ChIP-Seq_TH2_Mouse0.57673959
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.56744008

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.95114263
2MP0002166_altered_tumor_susceptibility4.71165384
3MP0005671_abnormal_response_to4.70755957
4MP0002006_tumorigenesis3.63678463
5MP0001835_abnormal_antigen_presentation3.60318505
6MP0000685_abnormal_immune_system3.54153752
7MP0005000_abnormal_immune_tolerance2.95129501
8MP0001790_abnormal_immune_system2.91853466
9MP0005387_immune_system_phenotype2.91853466
10MP0009785_altered_susceptibility_to2.87902092
11MP0009333_abnormal_splenocyte_physiolog2.84766779
12MP0001800_abnormal_humoral_immune2.78457896
13MP0006082_CNS_inflammation2.73108205
14MP0002723_abnormal_immune_serum2.63292575
15MP0002398_abnormal_bone_marrow2.58172301
16MP0000703_abnormal_thymus_morphology2.57953707
17MP0002420_abnormal_adaptive_immunity2.56898469
18MP0001819_abnormal_immune_cell2.53260859
19MP0003724_increased_susceptibility_to2.51811550
20MP0001873_stomach_inflammation2.41136514
21MP0005025_abnormal_response_to2.40140893
22MP0004510_myositis2.37339114
23MP0010155_abnormal_intestine_physiology2.36478499
24MP0003866_abnormal_defecation2.32554785
25MP0002405_respiratory_system_inflammati2.29250648
26MP0000716_abnormal_immune_system2.28859896
27MP0002009_preneoplasia2.27640188
28MP0003436_decreased_susceptibility_to2.22216399
29MP0002722_abnormal_immune_system2.16124859
30MP0002452_abnormal_antigen_presenting2.14603165
31MP0005310_abnormal_salivary_gland2.10730731
32MP0004381_abnormal_hair_follicle2.09988740
33MP0003300_gastrointestinal_ulcer2.05434970
34MP0002933_joint_inflammation1.98064838
35MP0002822_catalepsy1.95049732
36MP0003303_peritoneal_inflammation1.94150858
37MP0000689_abnormal_spleen_morphology1.93804397
38MP0004947_skin_inflammation1.80836887
39MP0002429_abnormal_blood_cell1.76366203
40MP0001348_abnormal_lacrimal_gland1.73634828
41MP0002138_abnormal_hepatobiliary_system1.71826076
42MP0002163_abnormal_gland_morphology1.71203378
43MP0002396_abnormal_hematopoietic_system1.57398924
44MP0000465_gastrointestinal_hemorrhage1.56130770
45MP0001845_abnormal_inflammatory_respons1.52975179
46MP0002419_abnormal_innate_immunity1.50041808
47MP0005464_abnormal_platelet_physiology1.34189991
48MP0004808_abnormal_hematopoietic_stem1.31611088
49MP0008260_abnormal_autophagy1.30248418
50MP0002277_abnormal_respiratory_mucosa1.27245936
51MP0002148_abnormal_hypersensitivity_rea1.26671290
52MP0005670_abnormal_white_adipose1.18704034
53MP0001851_eye_inflammation1.18050056
54MP0010352_gastrointestinal_tract_polyps1.14135794
55MP0001661_extended_life_span1.13966626
56MP0003045_fibrosis1.10908760
57MP0008469_abnormal_protein_level1.07358990
58MP0003806_abnormal_nucleotide_metabolis0.99360699
59MP0001853_heart_inflammation0.98822645
60MP0008961_abnormal_basal_metabolism0.95369286
61MP0001533_abnormal_skeleton_physiology0.91605522
62MP0002132_abnormal_respiratory_system0.86913683
63MP0005379_endocrine/exocrine_gland_phen0.83183467
64MP0002638_abnormal_pupillary_reflex0.82152217
65MP0003787_abnormal_imprinting0.78393567
66MP0004130_abnormal_muscle_cell0.75876973
67MP0003690_abnormal_glial_cell0.74906201
68MP0000858_altered_metastatic_potential0.74189706
69MP0005423_abnormal_somatic_nervous0.73081695
70MP0001663_abnormal_digestive_system0.70821179
71MP0002019_abnormal_tumor_incidence0.70277410
72MP0000920_abnormal_myelination0.68657850
73MP0006072_abnormal_retinal_apoptosis0.68484574
74MP0008569_lethality_at_weaning0.68383949
75MP0000490_abnormal_crypts_of0.66786072
76MP0000609_abnormal_liver_physiology0.65445148
77MP0003448_altered_tumor_morphology0.65161897
78MP0009840_abnormal_foam_cell0.64300866
79MP0004142_abnormal_muscle_tone0.63503546
80MP0002998_abnormal_bone_remodeling0.61823674
81MP0005166_decreased_susceptibility_to0.60984035
82MP0005666_abnormal_adipose_tissue0.60889554
83MP0003183_abnormal_peptide_metabolism0.60242345
84MP0001346_abnormal_lacrimal_gland0.58124202
85MP0003878_abnormal_ear_physiology0.55904983
86MP0005377_hearing/vestibular/ear_phenot0.55904983
87MP0004883_abnormal_blood_vessel0.54578933
88MP0003879_abnormal_hair_cell0.54116443
89MP0004742_abnormal_vestibular_system0.54006588
90MP0009763_increased_sensitivity_to0.53602365
91MP0001764_abnormal_homeostasis0.53586007
92MP0005535_abnormal_body_temperature0.50923954
93MP0000249_abnormal_blood_vessel0.50882006
94MP0002089_abnormal_postnatal_growth/wei0.50751458
95MP0003011_delayed_dark_adaptation0.48891462
96MP0003221_abnormal_cardiomyocyte_apopto0.48255900
97MP0000604_amyloidosis0.46480044
98MP0001542_abnormal_bone_strength0.44668529
99MP0005023_abnormal_wound_healing0.44156140
100MP0005390_skeleton_phenotype0.43885269
101MP0000477_abnormal_intestine_morphology0.43656191
102MP0001986_abnormal_taste_sensitivity0.43408409
103MP0005381_digestive/alimentary_phenotyp0.43151678
104MP0003795_abnormal_bone_structure0.43115329
105MP0009115_abnormal_fat_cell0.42807510
106MP0005075_abnormal_melanosome_morpholog0.41925191
107MP0008872_abnormal_physiological_respon0.41518824
108MP0005319_abnormal_enzyme/_coenzyme0.41279754
109MP0008873_increased_physiological_sensi0.39891624
110MP0003172_abnormal_lysosome_physiology0.39782245
111MP0005334_abnormal_fat_pad0.39131667
112MP0003091_abnormal_cell_migration0.38652767
113MP0001191_abnormal_skin_condition0.38271143
114MP0009697_abnormal_copulation0.37958266
115MP0002083_premature_death0.34651968
116MP0004185_abnormal_adipocyte_glucose0.34461764
117MP0000613_abnormal_salivary_gland0.33436389
118MP0002693_abnormal_pancreas_physiology0.33262967
119MP0008874_decreased_physiological_sensi0.33227679
120MP0009765_abnormal_xenobiotic_induced0.32922762
121MP0001243_abnormal_dermal_layer0.32915502
122MP0009764_decreased_sensitivity_to0.32856347
123MP0005165_increased_susceptibility_to0.28806842
124MP0002136_abnormal_kidney_physiology0.28036181
125MP0008995_early_reproductive_senescence0.27000361
126MP0000598_abnormal_liver_morphology0.25942974
127MP0002168_other_aberrant_phenotype0.25444036

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.00947380
2Abnormality of T cell number (HP:0011839)8.76413192
3Increased IgM level (HP:0003496)8.60640515
4Aplastic anemia (HP:0001915)6.61448638
5Elevated erythrocyte sedimentation rate (HP:0003565)6.34877941
6Abnormality of T cells (HP:0002843)5.65194946
7Stomatitis (HP:0010280)5.18691815
8Autoimmune hemolytic anemia (HP:0001890)4.89823943
9Severe combined immunodeficiency (HP:0004430)4.89778225
10Abnormality of macrophages (HP:0004311)4.85568699
11IgG deficiency (HP:0004315)4.84239765
12Lymphopenia (HP:0001888)4.79538622
13Abnormality of cells of the lymphoid lineage (HP:0012140)4.61924097
14Combined immunodeficiency (HP:0005387)4.58512698
15Recurrent cutaneous fungal infections (HP:0011370)4.47676304
16Chronic mucocutaneous candidiasis (HP:0002728)4.47676304
17Recurrent bronchitis (HP:0002837)4.34772156
18Abnormality of eosinophils (HP:0001879)4.27323261
19Retrobulbar optic neuritis (HP:0100654)4.22214927
20Optic neuritis (HP:0100653)4.22214927
21Eosinophilia (HP:0001880)4.15581663
22Recurrent viral infections (HP:0004429)4.11163041
23Recurrent fungal infections (HP:0002841)4.01229658
24Abnormality of the nasal mucosa (HP:0000433)4.00168676
25Joint swelling (HP:0001386)3.98406304
26Hypergammaglobulinemia (HP:0010702)3.93764107
27Nasal polyposis (HP:0100582)3.88380593
28Leukocytosis (HP:0001974)3.83342856
29Gingival bleeding (HP:0000225)3.63740113
30Recurrent otitis media (HP:0000403)3.54143789
31Chronic diarrhea (HP:0002028)3.45485405
32Granulocytopenia (HP:0001913)3.39052445
33IgM deficiency (HP:0002850)3.30108165
34Spontaneous hematomas (HP:0007420)3.26574612
35Hypoplasia of the thymus (HP:0000778)3.26447937
36Eczematoid dermatitis (HP:0000976)3.19803355
37Colitis (HP:0002583)3.18291069
38Recurrent bacterial skin infections (HP:0005406)3.10081090
39Pulmonary infiltrates (HP:0002113)3.09194484
40Keratoconjunctivitis sicca (HP:0001097)3.06849124
41Panhypogammaglobulinemia (HP:0003139)3.05668616
42Bronchitis (HP:0012387)3.03691620
43Recurrent abscess formation (HP:0002722)3.02697127
44Vasculitis (HP:0002633)2.92048355
45Hypoproteinemia (HP:0003075)2.91758809
46Increased IgE level (HP:0003212)2.89890730
47Thyroiditis (HP:0100646)2.88054421
48Periorbital edema (HP:0100539)2.84275649
49Keratoconjunctivitis (HP:0001096)2.83812043
50Hemiplegia (HP:0002301)2.83725795
51Epistaxis (HP:0000421)2.79847166
52Acute hepatic failure (HP:0006554)2.79127032
53Amyotrophic lateral sclerosis (HP:0007354)2.79112371
54Hypochromic microcytic anemia (HP:0004840)2.76055332
55Facial edema (HP:0000282)2.73479701
56Reduced subcutaneous adipose tissue (HP:0003758)2.73404039
57Lymphoma (HP:0002665)2.70287179
58Pustule (HP:0200039)2.69461992
59Chronic otitis media (HP:0000389)2.60562488
60Abnormality of B cell number (HP:0010975)2.59202668
61B lymphocytopenia (HP:0010976)2.59202668
62Abnormality of T cell physiology (HP:0011840)2.50776739
63Abnormality of the fingertips (HP:0001211)2.50130756
64Myositis (HP:0100614)2.49411522
65Entropion (HP:0000621)2.48812814
66IgA deficiency (HP:0002720)2.42736615
67Cheilitis (HP:0100825)2.38425109
68Hemoptysis (HP:0002105)2.37447840
69Abnormality of the prostate (HP:0008775)2.37062627
70Large eyes (HP:0001090)2.35721836
71Hypochromic anemia (HP:0001931)2.35275425
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33450608
73Global brain atrophy (HP:0002283)2.33356066
74Hyperinsulinemic hypoglycemia (HP:0000825)2.28925716
75Prolonged bleeding time (HP:0003010)2.27444219
76Gastrointestinal infarctions (HP:0005244)2.26189757
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.26003176
78Anorexia (HP:0002039)2.25588388
79Abnormality of the columella (HP:0009929)2.25472470
80Recurrent skin infections (HP:0001581)2.19690057
81Prominent nose (HP:0000448)2.19024422
82Viral hepatitis (HP:0006562)2.18201706
83Poikiloderma (HP:0001029)2.17734270
84Pulmonary embolism (HP:0002204)2.15170286
85Microcytic anemia (HP:0001935)2.14929161
86Recurrent gram-negative bacterial infections (HP:0005420)2.11982141
87Petechiae (HP:0000967)2.10308899
88Autoimmune thrombocytopenia (HP:0001973)2.09637542
89Villous atrophy (HP:0011473)2.09563213
90Abnormality of small intestinal villus morphology (HP:0011472)2.09563213
91Oral leukoplakia (HP:0002745)2.07284249
92Mediastinal lymphadenopathy (HP:0100721)2.07003027
93Prostate neoplasm (HP:0100787)2.04274407
94Purpura (HP:0000979)2.03913318
95Recurrent sinusitis (HP:0011108)2.01491309
96Urticaria (HP:0001025)2.00949476
97Agammaglobulinemia (HP:0004432)1.99799980
98Bronchiectasis (HP:0002110)1.97157415
99Increased CSF protein (HP:0002922)1.96227842
100Microvesicular hepatic steatosis (HP:0001414)1.93725710
101Pancytopenia (HP:0001876)1.92830252
102Meningitis (HP:0001287)1.91994390
103Gangrene (HP:0100758)1.91518779
104Recurrent lower respiratory tract infections (HP:0002783)1.90934645
105Abnormality of the common coagulation pathway (HP:0010990)1.88286923
106Keratitis (HP:0000491)1.86937745
107Palpebral edema (HP:0100540)1.85634579
108Basal cell carcinoma (HP:0002671)1.84105911
109Progressive inability to walk (HP:0002505)1.83255205
110Hypertriglyceridemia (HP:0002155)1.81176884
111Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79265027
112Urinary urgency (HP:0000012)1.78425544
113Chest pain (HP:0100749)1.77387109
114Gastrointestinal inflammation (HP:0004386)1.77359842
115Encephalitis (HP:0002383)1.76777310
116Glomerulopathy (HP:0100820)1.75758508
117Abnormality of the pleura (HP:0002103)1.75082189
118Prominent metopic ridge (HP:0005487)1.74752488
119Frequent falls (HP:0002359)1.74618826
120Cutis marmorata (HP:0000965)1.73606539
121Polyneuropathy (HP:0001271)1.73342067
122Obstructive lung disease (HP:0006536)1.69844799
123Chronic obstructive pulmonary disease (HP:0006510)1.69844799
124Inflammation of the large intestine (HP:0002037)1.69834458
125Gingivitis (HP:0000230)1.68127857
126Arterial thrombosis (HP:0004420)1.67013432
127Hepatitis (HP:0012115)1.66581068
128Anhidrosis (HP:0000970)1.63924784
129Skin ulcer (HP:0200042)1.57820910
130Thrombocytosis (HP:0001894)1.56990498
131Orchitis (HP:0100796)1.55193431
132Thyroid-stimulating hormone excess (HP:0002925)1.54571160
133Abnormal platelet volume (HP:0011876)1.54499031
134Abnormality of DNA repair (HP:0003254)1.53552211
135Increased density of long bones (HP:0006392)1.52652935
136Basal ganglia calcification (HP:0002135)1.52593133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.29993762
2MAP4K14.56765068
3FGFR43.85079391
4ZAP703.71996095
5IKBKE3.57681978
6TESK23.24053237
7ITK3.15915342
8TYK23.05111594
9JAK33.00295298
10LCK2.32968574
11FGFR32.26685589
12NLK2.23599634
13GRK62.11140596
14RIPK42.10338589
15CSK2.03375079
16STK101.94063908
17TBK11.71621605
18KDR1.67878405
19JAK11.67252631
20HCK1.65778894
21KIT1.64057151
22BTK1.62207816
23IRAK41.59861271
24DYRK1B1.57106749
25SYK1.56057413
26TEC1.52904656
27MAP3K141.52288608
28UHMK11.50927287
29MAPKAPK31.41079529
30PRKCH1.35903065
31BLK1.30769898
32PDK41.30348065
33PDK31.30348065
34GRK71.25059450
35SCYL21.19875964
36ERN11.19072106
37TESK11.18249844
38EIF2AK31.11723100
39FES1.11412968
40NME21.10066895
41CAMKK21.09192098
42YES11.08947994
43PRKCQ1.07437779
44CDK61.05457870
45HIPK21.02146568
46PDGFRB0.95113738
47TNK20.94644450
48INSR0.94556769
49ALK0.89861863
50IKBKB0.88832199
51TAOK10.88104090
52FYN0.88092734
53BRD40.85893020
54LYN0.83790427
55JAK20.83196362
56MARK20.81707139
57SMG10.80496242
58PTK20.80405241
59PTK60.76929203
60DAPK10.76658561
61CDK190.75884810
62FGFR20.75489166
63SIK20.73284235
64EEF2K0.71646544
65MAP2K60.71297598
66MARK30.71117505
67OXSR10.68075081
68TYRO30.67313733
69CHUK0.64711720
70IGF1R0.61658167
71PINK10.60446211
72PDK20.59951557
73CAMKK10.59234976
74MAP3K120.57960344
75CDK40.57756388
76LIMK10.55240177
77MAP3K130.54734620
78EPHB10.54050054
79MAP3K70.52511592
80STK240.52303768
81FGFR10.51729490
82PTK2B0.51541346
83CDK120.51219794
84CDK90.50943877
85ROCK20.48043107
86MAPK110.46948322
87LRRK20.45132767
88TAF10.45033873
89SRC0.44598077
90STK40.44585035
91ABL10.44311966
92SIK30.43680934
93MAPKAPK20.43384941
94TNIK0.42041820
95CLK10.40468184
96TLK10.38770168
97ADRBK20.37704505
98ILK0.37322241
99PASK0.35955098
100MAPK30.35166739
101TSSK60.34675975
102ERBB20.34230401
103MAP3K30.34216064
104PDK10.33799559
105PIM10.33291970
106MAP3K10.32300785
107MST40.31644744
108MAP3K110.31182064
109MOS0.30910442
110RPS6KL10.29401250
111RPS6KC10.29401250
112CDK30.28691810
113TTN0.28561162
114GRK50.28370065
115PRPF4B0.28334613
116PRKCB0.28224888
117CSF1R0.27054228
118MELK0.26781194
119NTRK20.26245968
120TAOK20.25631344
121EGFR0.25236504
122MAPK80.24823836
123PKN20.24636309
124NEK60.24572429
125MAPK70.24506197
126MAP3K100.23317597
127PRKD10.21535912
128TAOK30.20914724
129TGFBR20.20710224
130EPHA30.20558838
131CSNK1D0.19628945
132MAP2K30.19189321
133STK110.17897882
134CSNK1G10.17659141
135CSNK2A20.17490214
136FGR0.16548530
137PAK60.16401268
138MKNK20.16273241
139STK390.16242224
140PRKD20.15634180

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.02342209
2T cell receptor signaling pathway_Homo sapiens_hsa046604.71553284
3Hematopoietic cell lineage_Homo sapiens_hsa046403.84420801
4Measles_Homo sapiens_hsa051623.56752662
5NF-kappa B signaling pathway_Homo sapiens_hsa040643.26006360
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.16171908
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.73083329
8Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.55397322
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.25151562
10Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.19820696
11Autoimmune thyroid disease_Homo sapiens_hsa053202.05429559
12Viral myocarditis_Homo sapiens_hsa054162.03775904
13Allograft rejection_Homo sapiens_hsa053302.01724242
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97964270
15Antigen processing and presentation_Homo sapiens_hsa046121.95622265
16Graft-versus-host disease_Homo sapiens_hsa053321.90451143
17Leishmaniasis_Homo sapiens_hsa051401.86025283
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78348079
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58679027
20Osteoclast differentiation_Homo sapiens_hsa043801.56686195
21Herpes simplex infection_Homo sapiens_hsa051681.50427072
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48370443
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.43412999
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41872248
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.41297550
26Malaria_Homo sapiens_hsa051441.24012412
27African trypanosomiasis_Homo sapiens_hsa051431.21968408
28Hepatitis B_Homo sapiens_hsa051611.18986564
29Legionellosis_Homo sapiens_hsa051341.18812963
30Regulation of autophagy_Homo sapiens_hsa041401.18717129
31Toxoplasmosis_Homo sapiens_hsa051451.18649430
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.12516220
33Type I diabetes mellitus_Homo sapiens_hsa049401.12129042
34Influenza A_Homo sapiens_hsa051641.06159929
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05203555
36HTLV-I infection_Homo sapiens_hsa051661.04895793
37B cell receptor signaling pathway_Homo sapiens_hsa046621.04276212
38Chemokine signaling pathway_Homo sapiens_hsa040620.98230849
39Salmonella infection_Homo sapiens_hsa051320.95114769
40Spliceosome_Homo sapiens_hsa030400.93003232
41Pertussis_Homo sapiens_hsa051330.91761439
42Sulfur relay system_Homo sapiens_hsa041220.91463705
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90172409
44Staphylococcus aureus infection_Homo sapiens_hsa051500.88750192
45Shigellosis_Homo sapiens_hsa051310.88270961
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87418053
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82471838
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81552677
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81294826
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81107412
51Hepatitis C_Homo sapiens_hsa051600.79128906
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77481840
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74227110
54Acute myeloid leukemia_Homo sapiens_hsa052210.74059702
55Non-homologous end-joining_Homo sapiens_hsa034500.63847010
56Non-small cell lung cancer_Homo sapiens_hsa052230.63318949
57Ribosome_Homo sapiens_hsa030100.62526891
58FoxO signaling pathway_Homo sapiens_hsa040680.62362176
59Prolactin signaling pathway_Homo sapiens_hsa049170.62303577
60One carbon pool by folate_Homo sapiens_hsa006700.60029107
61VEGF signaling pathway_Homo sapiens_hsa043700.58485654
62Tuberculosis_Homo sapiens_hsa051520.58327136
63Platelet activation_Homo sapiens_hsa046110.57100459
64Endocytosis_Homo sapiens_hsa041440.56117225
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54610032
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53789804
67Other glycan degradation_Homo sapiens_hsa005110.53648427
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49814708
69Choline metabolism in cancer_Homo sapiens_hsa052310.48530704
70Phagosome_Homo sapiens_hsa041450.48488949
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48281612
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46691135
73Pancreatic cancer_Homo sapiens_hsa052120.45983094
74Viral carcinogenesis_Homo sapiens_hsa052030.45399019
75TNF signaling pathway_Homo sapiens_hsa046680.43429138
76Asthma_Homo sapiens_hsa053100.43106399
77Glycerolipid metabolism_Homo sapiens_hsa005610.38331499
78Caffeine metabolism_Homo sapiens_hsa002320.38242722
79Phototransduction_Homo sapiens_hsa047440.38080851
80mRNA surveillance pathway_Homo sapiens_hsa030150.37958784
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35917767
82Renin secretion_Homo sapiens_hsa049240.35692344
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35317724
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34898074
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33051131
86Apoptosis_Homo sapiens_hsa042100.32047206
87Rap1 signaling pathway_Homo sapiens_hsa040150.32033207
88Epstein-Barr virus infection_Homo sapiens_hsa051690.30961128
89Fatty acid elongation_Homo sapiens_hsa000620.30177241
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.29241920
91Nucleotide excision repair_Homo sapiens_hsa034200.28930552
92Colorectal cancer_Homo sapiens_hsa052100.28644126
93Thyroid cancer_Homo sapiens_hsa052160.26178549
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25640338
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25292826
96Pyruvate metabolism_Homo sapiens_hsa006200.25094992
97Chronic myeloid leukemia_Homo sapiens_hsa052200.25049670
98p53 signaling pathway_Homo sapiens_hsa041150.23421655
99MAPK signaling pathway_Homo sapiens_hsa040100.23241290
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21934331
101Rheumatoid arthritis_Homo sapiens_hsa053230.20490249
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.17998821
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.17051127
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.16525904
105Lysine degradation_Homo sapiens_hsa003100.15070738
106Systemic lupus erythematosus_Homo sapiens_hsa053220.14893877
107Notch signaling pathway_Homo sapiens_hsa043300.14147652
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13491224
109Inositol phosphate metabolism_Homo sapiens_hsa005620.13467998
110Endometrial cancer_Homo sapiens_hsa052130.13057646
111ABC transporters_Homo sapiens_hsa020100.12667736
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.11161776
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10924229
114RNA degradation_Homo sapiens_hsa030180.10714632
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.10674065
116Dilated cardiomyopathy_Homo sapiens_hsa054140.09325207
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09288349
118RNA transport_Homo sapiens_hsa030130.08361632
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07574675
120Proteasome_Homo sapiens_hsa030500.06794130
121Ras signaling pathway_Homo sapiens_hsa040140.05546319
122Small cell lung cancer_Homo sapiens_hsa052220.05021709
123Adherens junction_Homo sapiens_hsa045200.04932265
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.04769080

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