TRAV8-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.03073776
2negative thymic T cell selection (GO:0045060)7.17443059
3positive regulation of gamma-delta T cell activation (GO:0046645)6.90919231
4positive T cell selection (GO:0043368)6.59882673
5cytidine deamination (GO:0009972)6.53349110
6cytidine metabolic process (GO:0046087)6.53349110
7cytidine catabolic process (GO:0006216)6.53349110
8regulation of regulatory T cell differentiation (GO:0045589)6.45443511
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.38330964
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.32308921
11tolerance induction (GO:0002507)6.25994949
12regulation of gamma-delta T cell differentiation (GO:0045586)6.13141038
13positive thymic T cell selection (GO:0045059)6.12723865
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.12683300
15pyrimidine ribonucleoside catabolic process (GO:0046133)6.02067111
16DNA deamination (GO:0045006)5.95987835
17thymic T cell selection (GO:0045061)5.94199674
18cellular response to interleukin-15 (GO:0071350)5.84367507
19negative regulation of cell killing (GO:0031342)5.80865089
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.80865089
21regulation of T cell tolerance induction (GO:0002664)5.71595426
22T cell selection (GO:0045058)5.66412176
23positive regulation of tolerance induction (GO:0002645)5.51240361
24regulation of gamma-delta T cell activation (GO:0046643)5.46744647
25response to interleukin-15 (GO:0070672)5.28723139
26leukocyte aggregation (GO:0070486)5.22651591
27regulation of B cell receptor signaling pathway (GO:0050855)4.94669948
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.87358910
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84208692
30regulation of tolerance induction (GO:0002643)4.70746074
31regulation of alpha-beta T cell proliferation (GO:0046640)4.53791562
32regulation of isotype switching to IgG isotypes (GO:0048302)4.46977630
33antigen processing and presentation of endogenous antigen (GO:0019883)4.43868564
34negative regulation of T cell mediated immunity (GO:0002710)4.36236002
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36103695
36positive regulation of granulocyte differentiation (GO:0030854)4.33004975
37T cell receptor signaling pathway (GO:0050852)4.32743970
38regulation of natural killer cell mediated immunity (GO:0002715)4.32454063
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.32454063
40positive regulation of alpha-beta T cell proliferation (GO:0046641)4.29709440
41T cell migration (GO:0072678)4.28605629
42positive regulation of B cell differentiation (GO:0045579)4.27019917
43positive regulation of natural killer cell mediated immunity (GO:0002717)4.24546709
44positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.20959522
45regulation of interleukin-2 biosynthetic process (GO:0045076)4.20053151
46positive regulation of T cell mediated cytotoxicity (GO:0001916)4.14928503
47regulation of T cell mediated cytotoxicity (GO:0001914)4.12910044
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.11198517
49activated T cell proliferation (GO:0050798)4.10986157
50regulation of leukocyte mediated cytotoxicity (GO:0001910)4.03394372
51regulation of B cell differentiation (GO:0045577)3.99231860
52positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.95569829
53antigen receptor-mediated signaling pathway (GO:0050851)3.95342816
54positive regulation of calcium-mediated signaling (GO:0050850)3.94606974
55production of molecular mediator involved in inflammatory response (GO:0002532)3.85566061
56regulation of T cell receptor signaling pathway (GO:0050856)3.84533107
57positive regulation of cell killing (GO:0031343)3.81808801
58positive regulation of defense response to virus by host (GO:0002230)3.76490568
59T cell costimulation (GO:0031295)3.74798666
60regulation of cell killing (GO:0031341)3.70716963
61lymphocyte costimulation (GO:0031294)3.70222849
62interferon-gamma production (GO:0032609)3.65997827
63mast cell activation (GO:0045576)3.65658187
64Arp2/3 complex-mediated actin nucleation (GO:0034314)3.62661714
65antigen processing and presentation via MHC class Ib (GO:0002475)3.58749405
66T cell differentiation (GO:0030217)3.52677149
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.50579635
68negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.45911641
69negative regulation of viral genome replication (GO:0045071)3.45314012
70positive regulation of T cell differentiation in thymus (GO:0033089)3.44750709
71alpha-beta T cell differentiation (GO:0046632)3.41836270
72type I interferon signaling pathway (GO:0060337)3.39912158
73cellular response to type I interferon (GO:0071357)3.39912158
74response to type I interferon (GO:0034340)3.35543507
75CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.32021484
76T-helper cell differentiation (GO:0042093)3.32021484
77positive regulation of interleukin-4 production (GO:0032753)3.31609005
78negative regulation of T cell apoptotic process (GO:0070233)3.25936380
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22240678
80negative regulation of T cell receptor signaling pathway (GO:0050860)3.18080605
81positive regulation of humoral immune response (GO:0002922)3.16898869
82lymphocyte migration (GO:0072676)3.15257970
83actin nucleation (GO:0045010)3.13963420
84positive regulation of T cell mediated immunity (GO:0002711)3.13675498
85alpha-beta T cell differentiation involved in immune response (GO:0002293)3.13232094
86alpha-beta T cell activation involved in immune response (GO:0002287)3.13232094
87T cell differentiation involved in immune response (GO:0002292)3.13232094
88T cell activation (GO:0042110)3.11380887
89alpha-beta T cell activation (GO:0046631)3.08561329
90regulation of defense response to virus by virus (GO:0050690)3.06804237
91regulation of alpha-beta T cell activation (GO:0046634)3.04902101
92pyrimidine nucleoside catabolic process (GO:0046135)3.04809613
93positive regulation of alpha-beta T cell activation (GO:0046635)3.04049184
94CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.00828555
95dendritic cell chemotaxis (GO:0002407)3.00511722
96T cell homeostasis (GO:0043029)2.98870300
97positive regulation of lymphocyte mediated immunity (GO:0002708)2.98353311
98B cell receptor signaling pathway (GO:0050853)2.96833116
99mast cell degranulation (GO:0043303)2.96143245
100mast cell activation involved in immune response (GO:0002279)2.96143245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.39416398
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.65993765
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.60119305
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.45595704
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.34876424
6RUNX_20019798_ChIP-Seq_JUKART_Human3.89170730
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71417959
8MYB_26560356_Chip-Seq_TH2_Human3.58125649
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.28560627
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.28054879
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.18575885
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07253535
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.98535288
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80213039
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.78909311
16MYB_26560356_Chip-Seq_TH1_Human2.77571916
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.77015387
18MAF_26560356_Chip-Seq_TH1_Human2.69948835
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61404506
20GATA3_27048872_Chip-Seq_THYMUS_Human2.51395498
21UTX_26944678_Chip-Seq_JUKART_Human2.43598222
22GATA3_26560356_Chip-Seq_TH2_Human2.32238029
23MAF_26560356_Chip-Seq_TH2_Human2.31522172
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.18572445
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15455349
26SPI1_23547873_ChIP-Seq_NB4_Human1.88455563
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86074838
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.81013774
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78980697
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72385850
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68082503
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.64220858
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61364151
34CIITA_25753668_ChIP-Seq_RAJI_Human1.59421798
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.58786864
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57344523
37VDR_23849224_ChIP-Seq_CD4+_Human1.54707303
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46855154
39SCL_19346495_ChIP-Seq_HPC-7_Human1.38416527
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34651908
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31679334
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30604918
43MYC_22102868_ChIP-Seq_BL_Human1.30150902
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22598662
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22219058
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21235448
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.20229882
48SPI1_23127762_ChIP-Seq_K562_Human1.18085959
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.13695033
50GATA3_26560356_Chip-Seq_TH1_Human1.12846723
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10204157
52TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07931285
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.07709690
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07502237
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07360898
56FOXP3_21729870_ChIP-Seq_TREG_Human1.07277195
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05878519
58BCL6_27268052_Chip-Seq_Bcells_Human1.03575287
59RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03232808
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02325933
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01410164
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01038633
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98512787
64EST1_17652178_ChIP-ChIP_JURKAT_Human0.98235283
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94792228
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92558565
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92041026
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88633194
69HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86425794
70P300_27268052_Chip-Seq_Bcells_Human0.86257020
71VDR_21846776_ChIP-Seq_THP-1_Human0.85789629
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85275539
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84744621
74GATA1_22025678_ChIP-Seq_K562_Human0.84507678
75VDR_24763502_ChIP-Seq_THP-1_Human0.82783647
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80388395
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79797487
78PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78713273
79PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77479380
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76532161
81PU_27001747_Chip-Seq_BMDM_Mouse0.76242454
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74855825
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74135418
84SPI1_20517297_ChIP-Seq_HL60_Human0.72243166
85KDM2B_26808549_Chip-Seq_DND41_Human0.70971194
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69943454
87BCOR_27268052_Chip-Seq_Bcells_Human0.69605883
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.69434652
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.68471979
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.68465666
91TCF7_22412390_ChIP-Seq_EML_Mouse0.68308430
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68113995
93EGR1_19032775_ChIP-ChIP_M12_Human0.67782247
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67575767
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67256871
96SMRT_27268052_Chip-Seq_Bcells_Human0.65579255
97NANOG_20526341_ChIP-Seq_ESCs_Human0.64666946
98SA1_27219007_Chip-Seq_Bcells_Human0.64098975
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.64048644
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.63846362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.36520565
2MP0003763_abnormal_thymus_physiology4.68466494
3MP0001873_stomach_inflammation3.96696476
4MP0001835_abnormal_antigen_presentation3.66260396
5MP0009333_abnormal_splenocyte_physiolog3.40340067
6MP0001800_abnormal_humoral_immune3.31540417
7MP0005000_abnormal_immune_tolerance3.20072043
8MP0003436_decreased_susceptibility_to3.14883631
9MP0002166_altered_tumor_susceptibility3.08659123
10MP0003724_increased_susceptibility_to2.94243342
11MP0002420_abnormal_adaptive_immunity2.77159443
12MP0001790_abnormal_immune_system2.74623077
13MP0005387_immune_system_phenotype2.74623077
14MP0002723_abnormal_immune_serum2.72537888
15MP0009785_altered_susceptibility_to2.71846393
16MP0001819_abnormal_immune_cell2.70819380
17MP0000685_abnormal_immune_system2.56869465
18MP0003866_abnormal_defecation2.54081174
19MP0002452_abnormal_antigen_presenting2.47699803
20MP0005025_abnormal_response_to2.47417797
21MP0002405_respiratory_system_inflammati2.37647214
22MP0002398_abnormal_bone_marrow2.37107708
23MP0000703_abnormal_thymus_morphology2.34319522
24MP0002148_abnormal_hypersensitivity_rea2.32046977
25MP0010155_abnormal_intestine_physiology2.30546074
26MP0002006_tumorigenesis2.28092882
27MP0000716_abnormal_immune_system2.27348545
28MP0006082_CNS_inflammation2.14505461
29MP0002009_preneoplasia2.07574899
30MP0004947_skin_inflammation2.03176502
31MP0002419_abnormal_innate_immunity1.98566816
32MP0000689_abnormal_spleen_morphology1.95198686
33MP0005310_abnormal_salivary_gland1.94949817
34MP0002933_joint_inflammation1.94579687
35MP0002722_abnormal_immune_system1.86825634
36MP0004381_abnormal_hair_follicle1.85595182
37MP0001853_heart_inflammation1.85189259
38MP0001845_abnormal_inflammatory_respons1.75895375
39MP0002429_abnormal_blood_cell1.73743795
40MP0002138_abnormal_hepatobiliary_system1.67424086
41MP0000465_gastrointestinal_hemorrhage1.66040591
42MP0002163_abnormal_gland_morphology1.61283936
43MP0002277_abnormal_respiratory_mucosa1.58170679
44MP0001533_abnormal_skeleton_physiology1.40663263
45MP0005075_abnormal_melanosome_morpholog1.38873321
46MP0008469_abnormal_protein_level1.29627384
47MP0003806_abnormal_nucleotide_metabolis1.26565431
48MP0003300_gastrointestinal_ulcer1.25890106
49MP0000490_abnormal_crypts_of1.25603209
50MP0005464_abnormal_platelet_physiology1.25228438
51MP0001663_abnormal_digestive_system1.15293132
52MP0001919_abnormal_reproductive_system1.14916940
53MP0009764_decreased_sensitivity_to1.11213600
54MP0001851_eye_inflammation1.07812982
55MP0003303_peritoneal_inflammation1.02391234
56MP0001348_abnormal_lacrimal_gland0.96283028
57MP0003448_altered_tumor_morphology0.93809443
58MP0000372_irregular_coat_pigmentation0.92730013
59MP0000858_altered_metastatic_potential0.92012032
60MP0005360_urolithiasis0.91343172
61MP0009763_increased_sensitivity_to0.88736960
62MP0004510_myositis0.86608938
63MP0002693_abnormal_pancreas_physiology0.85601281
64MP0002019_abnormal_tumor_incidence0.85016309
65MP0008995_early_reproductive_senescence0.83325325
66MP0002132_abnormal_respiratory_system0.81252589
67MP0002396_abnormal_hematopoietic_system0.78308448
68MP0005379_endocrine/exocrine_gland_phen0.77618350
69MP0003787_abnormal_imprinting0.72017746
70MP0002254_reproductive_system_inflammat0.69764018
71MP0003045_fibrosis0.69306780
72MP0002998_abnormal_bone_remodeling0.68394768
73MP0005381_digestive/alimentary_phenotyp0.66288528
74MP0003786_premature_aging0.65744068
75MP0001765_abnormal_ion_homeostasis0.64891729
76MP0003252_abnormal_bile_duct0.63389075
77MP0005166_decreased_susceptibility_to0.61028747
78MP0001346_abnormal_lacrimal_gland0.59731896
79MP0008873_increased_physiological_sensi0.57048729
80MP0005645_abnormal_hypothalamus_physiol0.56314233
81MP0003191_abnormal_cellular_cholesterol0.51484904
82MP0009765_abnormal_xenobiotic_induced0.50417505
83MP0001501_abnormal_sleep_pattern0.50318602
84MP0005390_skeleton_phenotype0.49420103
85MP0000604_amyloidosis0.49260285
86MP0002136_abnormal_kidney_physiology0.48666733
87MP0005389_reproductive_system_phenotype0.47699196
88MP0000477_abnormal_intestine_morphology0.46538764
89MP0009643_abnormal_urine_homeostasis0.44749590
90MP0004883_abnormal_blood_vessel0.44263254
91MP0000249_abnormal_blood_vessel0.43482252
92MP0001986_abnormal_taste_sensitivity0.43156953
93MP0001764_abnormal_homeostasis0.41713446
94MP0003795_abnormal_bone_structure0.40083091
95MP0000609_abnormal_liver_physiology0.38663595
96MP0008872_abnormal_physiological_respon0.37724977
97MP0003172_abnormal_lysosome_physiology0.37434099
98MP0005636_abnormal_mineral_homeostasis0.36940059
99MP0001191_abnormal_skin_condition0.35629874
100MP0009642_abnormal_blood_homeostasis0.34497154

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.19762607
2Abnormality of T cell number (HP:0011839)6.75211064
3Elevated erythrocyte sedimentation rate (HP:0003565)6.74534207
4Severe combined immunodeficiency (HP:0004430)5.90181985
5Autoimmune hemolytic anemia (HP:0001890)5.65400820
6Abnormality of T cells (HP:0002843)5.11979000
7Stomatitis (HP:0010280)5.01584773
8IgG deficiency (HP:0004315)4.92768452
9Combined immunodeficiency (HP:0005387)4.66776336
10Eczematoid dermatitis (HP:0000976)4.30948825
11Myositis (HP:0100614)4.06037600
12Chronic diarrhea (HP:0002028)4.05644585
13Increased IgM level (HP:0003496)3.97673673
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.90109213
15Abnormality of eosinophils (HP:0001879)3.87638374
16Aplastic anemia (HP:0001915)3.85236317
17Optic neuritis (HP:0100653)3.76913544
18Retrobulbar optic neuritis (HP:0100654)3.76913544
19Recurrent fungal infections (HP:0002841)3.73296562
20Encephalitis (HP:0002383)3.66695034
21Recurrent bronchitis (HP:0002837)3.60638560
22Pulmonary infiltrates (HP:0002113)3.60537605
23Slow saccadic eye movements (HP:0000514)3.53867804
24Abnormality of T cell physiology (HP:0011840)3.50038708
25Thyroiditis (HP:0100646)3.48950660
26Orchitis (HP:0100796)3.44357458
27Panhypogammaglobulinemia (HP:0003139)3.42226304
28Chronic mucocutaneous candidiasis (HP:0002728)3.41388910
29Recurrent cutaneous fungal infections (HP:0011370)3.41388910
30Meningitis (HP:0001287)3.40149122
31Gastrointestinal infarctions (HP:0005244)3.36449796
32Eosinophilia (HP:0001880)3.33998559
33Vasculitis (HP:0002633)3.30904415
34Hypoproteinemia (HP:0003075)3.26541228
35Granulocytopenia (HP:0001913)3.26328431
36Recurrent abscess formation (HP:0002722)3.25530858
37Lymphopenia (HP:0001888)3.24582063
38Leukocytosis (HP:0001974)3.24295640
39Abnormality of the prostate (HP:0008775)3.20436841
40Pustule (HP:0200039)3.18662929
41Recurrent bacterial skin infections (HP:0005406)3.15627773
42Recurrent viral infections (HP:0004429)3.09615086
43Abnormality of cells of the lymphoid lineage (HP:0012140)3.09190957
44Joint swelling (HP:0001386)3.06332010
45Chronic obstructive pulmonary disease (HP:0006510)3.05970274
46Obstructive lung disease (HP:0006536)3.05970274
47Abnormality of macrophages (HP:0004311)3.05484708
48Hemoptysis (HP:0002105)2.93834478
49IgM deficiency (HP:0002850)2.83130170
50Hypergammaglobulinemia (HP:0010702)2.82676151
51Keratoconjunctivitis sicca (HP:0001097)2.81040257
52Chest pain (HP:0100749)2.78480121
53Keratoconjunctivitis (HP:0001096)2.73722895
54Mediastinal lymphadenopathy (HP:0100721)2.73363852
55Recurrent skin infections (HP:0001581)2.71600210
56Gangrene (HP:0100758)2.70346792
57B lymphocytopenia (HP:0010976)2.63041654
58Pulmonary embolism (HP:0002204)2.62641743
59Agammaglobulinemia (HP:0004432)2.62239263
60Autoimmune thrombocytopenia (HP:0001973)2.57365877
613-Methylglutaconic aciduria (HP:0003535)2.54543427
62Abnormality of B cell number (HP:0010975)2.51806697
63Inflammation of the large intestine (HP:0002037)2.51782417
64Hypoplasia of the thymus (HP:0000778)2.51234217
65Lymphoma (HP:0002665)2.35972788
66Abnormality of the pleura (HP:0002103)2.35091067
67Gastrointestinal inflammation (HP:0004386)2.31452103
68Alveolar cell carcinoma (HP:0006519)2.29376188
69Increased IgE level (HP:0003212)2.28945438
70Bronchitis (HP:0012387)2.26600843
71Attenuation of retinal blood vessels (HP:0007843)2.12343747
72Recurrent otitis media (HP:0000403)2.11416567
73Spontaneous hematomas (HP:0007420)2.09922344
74Microcytic anemia (HP:0001935)2.06047945
75Anorexia (HP:0002039)2.04614320
76Oral leukoplakia (HP:0002745)2.04222039
77Petechiae (HP:0000967)2.00832644
78Abnormality of male internal genitalia (HP:0000022)1.99860967
79Pulmonary fibrosis (HP:0002206)1.99674959
80Ureteral stenosis (HP:0000071)1.98426928
81Keratitis (HP:0000491)1.98348279
82Pancytopenia (HP:0001876)1.96906232
83Neoplasm of the tracheobronchial system (HP:0100552)1.96488782
84Ureteral obstruction (HP:0006000)1.93452012
85Epistaxis (HP:0000421)1.93434611
86Hypochromic anemia (HP:0001931)1.92969189
87Glomerulopathy (HP:0100820)1.92507726
88Prostate neoplasm (HP:0100787)1.89441738
89Skin rash (HP:0000988)1.86654831
90Abnormality of the pericardium (HP:0001697)1.80973654
91Polyneuropathy (HP:0001271)1.80442038
92Arterial thrombosis (HP:0004420)1.77258529
93Chronic otitis media (HP:0000389)1.74711080
94IgA deficiency (HP:0002720)1.74478366
95Arthralgia (HP:0002829)1.74326159
96Recurrent sinusitis (HP:0011108)1.73442814
97Verrucae (HP:0200043)1.71903312
98Papilloma (HP:0012740)1.71903312
99Increased intramyocellular lipid droplets (HP:0012240)1.71512968
100Hematochezia (HP:0002573)1.71471499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.60982602
2MAP4K14.91418518
3FES3.09936753
4KDR2.96417283
5TAOK32.92328739
6ITK2.74559189
7TESK22.52279197
8TLK12.47487748
9ZAP702.40656340
10TNK22.32143407
11CSK2.23782382
12RIPK42.18341277
13CAMKK22.07733314
14TYK21.97370978
15GRK61.97071206
16ZAK1.95547201
17IKBKE1.94173194
18SYK1.88533945
19LCK1.85705000
20BTK1.83555575
21MAP3K111.76670207
22TEC1.75058678
23PASK1.67449830
24MST41.65111304
25JAK31.50989114
26JAK11.47638233
27TAOK21.42854188
28HCK1.42377264
29CAMKK11.36003039
30TYRO31.35700213
31MAP3K121.34587526
32PRKCQ1.29710341
33CSF1R1.28182380
34NLK1.25757594
35LYN1.25692743
36TAOK11.17449981
37SIK31.15373691
38IRAK41.12925305
39PIM11.03197257
40IKBKB1.02325905
41MARK31.00245872
42GRK70.99135744
43KIT0.98378440
44MAPKAPK30.97990049
45PRPF4B0.97698138
46JAK20.97066151
47SCYL20.94886732
48ADRBK20.94247346
49MAP2K60.84479554
50STK100.81641057
51MAP3K30.76293836
52MAPK110.75341383
53CDK40.70790523
54TBK10.70372273
55MAP3K140.69961251
56FGFR40.68433041
57BMPR20.67291072
58TESK10.66946752
59FYN0.65816053
60SIK20.65327283
61PIK3CG0.64018040
62BLK0.62802731
63MATK0.61289660
64MAP3K130.61289164
65MAP3K50.59338057
66INSR0.52445036
67PDK10.49069373
68CLK10.48168958
69PDGFRB0.45920947
70ADRBK10.43892104
71MAP2K30.43673493
72WNK40.42596716
73IGF1R0.42000758
74TGFBR20.41980503
75MAP3K10.40765329
76TRPM70.40612859
77MAPKAPK20.37727184
78FGFR30.37014845
79VRK10.36295285
80LRRK20.30287165
81IRAK20.27913937
82PRKCH0.25889339
83RPS6KA50.24268927
84GRK50.20571656
85STK380.19798554
86EGFR0.19726147
87STK390.18482977
88RAF10.17423676
89MAPK130.16575510
90MAPK30.15932648
91ABL10.14493055
92NEK60.13629017
93PRKCA0.12809257
94MELK0.12145817
95EPHB10.11375629
96NTRK20.10737889
97FGR0.09939193
98CHUK0.09440390
99PRKCD0.09335812
100GRK10.08276849

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.86448258
2T cell receptor signaling pathway_Homo sapiens_hsa046603.97012539
3Autoimmune thyroid disease_Homo sapiens_hsa053203.71047204
4Graft-versus-host disease_Homo sapiens_hsa053323.59409508
5Allograft rejection_Homo sapiens_hsa053303.40449486
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.10976469
7Antigen processing and presentation_Homo sapiens_hsa046122.87083487
8Hematopoietic cell lineage_Homo sapiens_hsa046402.77244122
9Measles_Homo sapiens_hsa051622.57027935
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51944046
11Type I diabetes mellitus_Homo sapiens_hsa049402.45930757
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.12807124
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96634481
14Proteasome_Homo sapiens_hsa030501.95151359
15Viral myocarditis_Homo sapiens_hsa054161.84092588
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.83283689
17Osteoclast differentiation_Homo sapiens_hsa043801.72139311
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60864067
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56994095
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.52455487
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44836722
22Herpes simplex infection_Homo sapiens_hsa051681.36933335
23Chemokine signaling pathway_Homo sapiens_hsa040621.34461061
24Leishmaniasis_Homo sapiens_hsa051401.30381985
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28564050
26B cell receptor signaling pathway_Homo sapiens_hsa046621.24733184
27Asthma_Homo sapiens_hsa053101.22359663
28Staphylococcus aureus infection_Homo sapiens_hsa051501.17074180
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11443008
30Shigellosis_Homo sapiens_hsa051311.11266745
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11060459
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10976301
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07638707
34Malaria_Homo sapiens_hsa051441.06419801
35Rheumatoid arthritis_Homo sapiens_hsa053231.05796458
36TNF signaling pathway_Homo sapiens_hsa046681.03950153
37Regulation of autophagy_Homo sapiens_hsa041401.01299505
38Ribosome_Homo sapiens_hsa030100.89564890
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84759349
40HTLV-I infection_Homo sapiens_hsa051660.82724155
41Epstein-Barr virus infection_Homo sapiens_hsa051690.79785294
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79178342
43Tuberculosis_Homo sapiens_hsa051520.79142306
44Nitrogen metabolism_Homo sapiens_hsa009100.78872568
45Phototransduction_Homo sapiens_hsa047440.77937026
46Toxoplasmosis_Homo sapiens_hsa051450.77702314
47Hepatitis B_Homo sapiens_hsa051610.77255784
48Linoleic acid metabolism_Homo sapiens_hsa005910.73279909
49Influenza A_Homo sapiens_hsa051640.71364886
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64601000
51Apoptosis_Homo sapiens_hsa042100.64103078
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63303999
53RNA polymerase_Homo sapiens_hsa030200.62567986
54Platelet activation_Homo sapiens_hsa046110.61938891
55African trypanosomiasis_Homo sapiens_hsa051430.61588759
56Viral carcinogenesis_Homo sapiens_hsa052030.61346928
57Non-small cell lung cancer_Homo sapiens_hsa052230.59793874
58Acute myeloid leukemia_Homo sapiens_hsa052210.55203413
59Endocytosis_Homo sapiens_hsa041440.53559393
60Salmonella infection_Homo sapiens_hsa051320.51926561
61RNA degradation_Homo sapiens_hsa030180.51380935
62Oxidative phosphorylation_Homo sapiens_hsa001900.51265058
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.50516212
64Legionellosis_Homo sapiens_hsa051340.48365913
65MAPK signaling pathway_Homo sapiens_hsa040100.47033531
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46382546
67Ether lipid metabolism_Homo sapiens_hsa005650.43214948
68VEGF signaling pathway_Homo sapiens_hsa043700.43070926
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39603145
70Pertussis_Homo sapiens_hsa051330.38280081
71Parkinsons disease_Homo sapiens_hsa050120.35585239
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32545328
73Ras signaling pathway_Homo sapiens_hsa040140.32001328
74Hepatitis C_Homo sapiens_hsa051600.30469511
75Olfactory transduction_Homo sapiens_hsa047400.28186187
76Alzheimers disease_Homo sapiens_hsa050100.23727107
77Systemic lupus erythematosus_Homo sapiens_hsa053220.23045348
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22633987
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.22480620
80Phagosome_Homo sapiens_hsa041450.22251071
81Circadian rhythm_Homo sapiens_hsa047100.21161053
82FoxO signaling pathway_Homo sapiens_hsa040680.21133453
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21127792
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20819619
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17855101
86Pancreatic cancer_Homo sapiens_hsa052120.17117637
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15652789
88Arachidonic acid metabolism_Homo sapiens_hsa005900.14261621
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.13990756
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.13567410
91Spliceosome_Homo sapiens_hsa030400.13070467
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12775322
93Mineral absorption_Homo sapiens_hsa049780.10995452
94Prolactin signaling pathway_Homo sapiens_hsa049170.07280515
95Peroxisome_Homo sapiens_hsa041460.07086988
96Colorectal cancer_Homo sapiens_hsa052100.06174472
97Oxytocin signaling pathway_Homo sapiens_hsa049210.02690148
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.02361962
99Morphine addiction_Homo sapiens_hsa050320.02072913
100Long-term potentiation_Homo sapiens_hsa047200.01697659

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