TRAV8-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.32298635
2negative thymic T cell selection (GO:0045060)7.41169094
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.68081234
4positive regulation of gamma-delta T cell activation (GO:0046645)6.56344978
5positive T cell selection (GO:0043368)6.53713277
6regulation of regulatory T cell differentiation (GO:0045589)6.23418767
7thymic T cell selection (GO:0045061)6.17838793
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.14141345
9T cell selection (GO:0045058)5.99478224
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.97978289
11positive thymic T cell selection (GO:0045059)5.96839814
12cytidine deamination (GO:0009972)5.94216380
13cytidine metabolic process (GO:0046087)5.94216380
14cytidine catabolic process (GO:0006216)5.94216380
15regulation of T cell tolerance induction (GO:0002664)5.91262476
16positive regulation of tolerance induction (GO:0002645)5.90081112
17regulation of B cell receptor signaling pathway (GO:0050855)5.65247219
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.64460872
19cellular response to interleukin-15 (GO:0071350)5.58057177
20regulation of gamma-delta T cell differentiation (GO:0045586)5.53269163
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.49259410
22negative regulation of cell killing (GO:0031342)5.49259410
23pyrimidine ribonucleoside catabolic process (GO:0046133)5.37296869
24response to interleukin-15 (GO:0070672)5.22319447
25leukocyte aggregation (GO:0070486)5.22161119
26T cell migration (GO:0072678)5.17956575
27regulation of tolerance induction (GO:0002643)5.06261004
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.90126165
29tolerance induction (GO:0002507)4.87470854
30regulation of gamma-delta T cell activation (GO:0046643)4.83937824
31DNA deamination (GO:0045006)4.77908271
32T cell receptor signaling pathway (GO:0050852)4.77344156
33regulation of interleukin-2 biosynthetic process (GO:0045076)4.71895329
34Arp2/3 complex-mediated actin nucleation (GO:0034314)4.68866881
35positive regulation of B cell differentiation (GO:0045579)4.65627053
36positive regulation of alpha-beta T cell proliferation (GO:0046641)4.55881865
37antigen processing and presentation of endogenous antigen (GO:0019883)4.47749982
38regulation of alpha-beta T cell proliferation (GO:0046640)4.40113334
39positive regulation of natural killer cell mediated immunity (GO:0002717)4.37035514
40regulation of isotype switching to IgG isotypes (GO:0048302)4.36658337
41antigen receptor-mediated signaling pathway (GO:0050851)4.32469622
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30241924
43regulation of natural killer cell mediated immunity (GO:0002715)4.28533022
44regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.28533022
45regulation of B cell differentiation (GO:0045577)4.21316291
46positive regulation of interleukin-4 production (GO:0032753)4.15942497
47positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.15119864
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.06849999
49actin nucleation (GO:0045010)4.03990286
50positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.02209113
51regulation of leukocyte mediated cytotoxicity (GO:0001910)3.94507864
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.93772564
53T cell costimulation (GO:0031295)3.91647426
54regulation of T cell mediated cytotoxicity (GO:0001914)3.89054823
55lymphocyte costimulation (GO:0031294)3.86866563
56negative regulation of T cell apoptotic process (GO:0070233)3.86803142
57interferon-gamma production (GO:0032609)3.86019696
58positive regulation of granulocyte differentiation (GO:0030854)3.83421105
59antigen processing and presentation via MHC class Ib (GO:0002475)3.79657844
60type I interferon signaling pathway (GO:0060337)3.77715103
61cellular response to type I interferon (GO:0071357)3.77715103
62positive regulation of calcium-mediated signaling (GO:0050850)3.76905034
63signal complex assembly (GO:0007172)3.76722887
64response to type I interferon (GO:0034340)3.73319228
65positive regulation of cell killing (GO:0031343)3.69712636
66mast cell activation (GO:0045576)3.67925091
67regulation of cell killing (GO:0031341)3.64542859
68positive regulation of interleukin-2 production (GO:0032743)3.63475059
69negative regulation of T cell mediated immunity (GO:0002710)3.62108059
70regulation of T cell receptor signaling pathway (GO:0050856)3.61927513
71negative regulation of viral genome replication (GO:0045071)3.56058426
72T cell differentiation (GO:0030217)3.52190796
73positive regulation of T cell differentiation in thymus (GO:0033089)3.51036626
74alpha-beta T cell differentiation (GO:0046632)3.48730401
75regulation of interleukin-4 production (GO:0032673)3.41735623
76negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.41310865
77positive regulation of T cell mediated immunity (GO:0002711)3.35047183
78activated T cell proliferation (GO:0050798)3.34379062
79lymphocyte migration (GO:0072676)3.33785256
80alpha-beta T cell activation (GO:0046631)3.22482080
81regulation of defense response to virus by virus (GO:0050690)3.21258656
82T cell activation (GO:0042110)3.20710729
83negative regulation of lymphocyte mediated immunity (GO:0002707)3.14358204
84B cell receptor signaling pathway (GO:0050853)3.11061430
85positive regulation of alpha-beta T cell activation (GO:0046635)3.07645357
86T-helper cell differentiation (GO:0042093)3.06158082
87CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.06158082
88negative regulation of stress fiber assembly (GO:0051497)3.04945055
89positive regulation of lymphocyte mediated immunity (GO:0002708)3.04163773
90regulation of T cell mediated immunity (GO:0002709)3.03496931
91T cell homeostasis (GO:0043029)3.02404959
92chemokine-mediated signaling pathway (GO:0070098)2.97792666
93immune response-activating cell surface receptor signaling pathway (GO:0002429)2.97788224
94response to interferon-beta (GO:0035456)2.96475438
95regulation of alpha-beta T cell activation (GO:0046634)2.94437794
96alpha-beta T cell differentiation involved in immune response (GO:0002293)2.94238512
97alpha-beta T cell activation involved in immune response (GO:0002287)2.94238512
98T cell differentiation involved in immune response (GO:0002292)2.94238512
99CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.94189215
100regulation of viral genome replication (GO:0045069)2.89442539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.59231856
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.39440507
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.80879978
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.94824029
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.05878566
6RUNX_20019798_ChIP-Seq_JUKART_Human3.81085172
7MYB_26560356_Chip-Seq_TH2_Human3.63892523
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44950893
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.34449464
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.28780416
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.21136038
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04343304
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.82080019
14MYB_26560356_Chip-Seq_TH1_Human2.77595664
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70514988
16MAF_26560356_Chip-Seq_TH1_Human2.65335238
17GATA3_27048872_Chip-Seq_THYMUS_Human2.63980814
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.62539217
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61686437
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55920201
21UTX_26944678_Chip-Seq_JUKART_Human2.52890230
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45765246
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43125132
24GATA3_26560356_Chip-Seq_TH2_Human2.16326586
25MAF_26560356_Chip-Seq_TH2_Human2.08491907
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.06264969
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.04676877
28SCL_19346495_ChIP-Seq_HPC-7_Human2.04273351
29SPI1_23547873_ChIP-Seq_NB4_Human1.94863452
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.89542457
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88874955
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81082905
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80023324
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74233364
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72927402
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72634158
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64619059
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60432323
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57858819
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54303615
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54260336
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46797801
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44017355
44SPI1_23127762_ChIP-Seq_K562_Human1.43726493
45VDR_23849224_ChIP-Seq_CD4+_Human1.35428453
46CIITA_25753668_ChIP-Seq_RAJI_Human1.30759915
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.29315319
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23078823
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22861150
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17971179
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17096970
52MYC_22102868_ChIP-Seq_BL_Human1.14385629
53BCL6_27268052_Chip-Seq_Bcells_Human1.11167446
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.09272806
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05604407
56VDR_24787735_ChIP-Seq_THP-1_Human1.05180059
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05043255
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03837682
59VDR_24763502_ChIP-Seq_THP-1_Human1.03179113
60FOXP3_21729870_ChIP-Seq_TREG_Human1.03123946
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02658961
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00395434
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98049278
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92899776
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92817641
66GATA1_19941827_ChIP-Seq_MEL_Mouse0.90264716
67FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90000399
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89835293
69RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89706267
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88788872
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88561027
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88047927
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85297294
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84342277
75GATA3_26560356_Chip-Seq_TH1_Human0.83051885
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82596234
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81977678
78EGR1_19032775_ChIP-ChIP_M12_Human0.80662565
79GATA1_22025678_ChIP-Seq_K562_Human0.79626027
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77260953
81SPI1_20517297_ChIP-Seq_HL60_Human0.77059753
82GATA1_19941826_ChIP-Seq_K562_Human0.76507320
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76160729
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74954395
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72634409
86PU_27001747_Chip-Seq_BMDM_Mouse0.70917434
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70369566
88VDR_21846776_ChIP-Seq_THP-1_Human0.69615602
89TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.68734944
90KDM2B_26808549_Chip-Seq_DND41_Human0.68681311
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68673786
92P300_27268052_Chip-Seq_Bcells_Human0.68492615
93BCOR_27268052_Chip-Seq_Bcells_Human0.67417836
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66807027
95NANOG_20526341_ChIP-Seq_ESCs_Human0.66603094
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66570725
97TCF7_22412390_ChIP-Seq_EML_Mouse0.65377186
98CEBPB_22108803_ChIP-Seq_LS180_Human0.65258901
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.64924401
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64717641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.42591048
2MP0003763_abnormal_thymus_physiology4.83618204
3MP0001835_abnormal_antigen_presentation3.70529761
4MP0001873_stomach_inflammation3.62989914
5MP0009785_altered_susceptibility_to3.41499712
6MP0001800_abnormal_humoral_immune3.30417471
7MP0005000_abnormal_immune_tolerance3.25223803
8MP0003436_decreased_susceptibility_to3.15451804
9MP0003724_increased_susceptibility_to2.98990544
10MP0002166_altered_tumor_susceptibility2.91217869
11MP0009333_abnormal_splenocyte_physiolog2.88824453
12MP0002420_abnormal_adaptive_immunity2.81852570
13MP0002723_abnormal_immune_serum2.78902317
14MP0001819_abnormal_immune_cell2.77305064
15MP0005025_abnormal_response_to2.68484624
16MP0001790_abnormal_immune_system2.60759386
17MP0005387_immune_system_phenotype2.60759386
18MP0000685_abnormal_immune_system2.53581862
19MP0002452_abnormal_antigen_presenting2.51170227
20MP0002148_abnormal_hypersensitivity_rea2.45611398
21MP0003866_abnormal_defecation2.44829376
22MP0002398_abnormal_bone_marrow2.41113962
23MP0000703_abnormal_thymus_morphology2.39989964
24MP0002405_respiratory_system_inflammati2.38441141
25MP0002009_preneoplasia2.28332208
26MP0000716_abnormal_immune_system2.27590417
27MP0004947_skin_inflammation2.19830034
28MP0010155_abnormal_intestine_physiology2.08723866
29MP0002419_abnormal_innate_immunity2.06810154
30MP0002006_tumorigenesis2.04540465
31MP0000465_gastrointestinal_hemorrhage2.01320702
32MP0002933_joint_inflammation2.01095231
33MP0004381_abnormal_hair_follicle1.95788111
34MP0002722_abnormal_immune_system1.95288223
35MP0006082_CNS_inflammation1.94774588
36MP0000689_abnormal_spleen_morphology1.93228083
37MP0001845_abnormal_inflammatory_respons1.73004191
38MP0002429_abnormal_blood_cell1.72024159
39MP0005464_abnormal_platelet_physiology1.66839906
40MP0005075_abnormal_melanosome_morpholog1.57805502
41MP0005310_abnormal_salivary_gland1.51672775
42MP0001533_abnormal_skeleton_physiology1.51152990
43MP0003045_fibrosis1.47184955
44MP0001853_heart_inflammation1.46955198
45MP0002277_abnormal_respiratory_mucosa1.32492613
46MP0008469_abnormal_protein_level1.30291025
47MP0009764_decreased_sensitivity_to1.25238311
48MP0003300_gastrointestinal_ulcer1.18456416
49MP0003448_altered_tumor_morphology1.09622872
50MP0005645_abnormal_hypothalamus_physiol1.08585486
51MP0002132_abnormal_respiratory_system1.05302417
52MP0005166_decreased_susceptibility_to1.02049403
53MP0009763_increased_sensitivity_to1.01187632
54MP0002138_abnormal_hepatobiliary_system0.98435262
55MP0001851_eye_inflammation0.97909709
56MP0000858_altered_metastatic_potential0.94291417
57MP0002163_abnormal_gland_morphology0.94079852
58MP0001348_abnormal_lacrimal_gland0.93891579
59MP0008995_early_reproductive_senescence0.88348067
60MP0003191_abnormal_cellular_cholesterol0.86229453
61MP0002693_abnormal_pancreas_physiology0.85536973
62MP0001663_abnormal_digestive_system0.80665884
63MP0001986_abnormal_taste_sensitivity0.79899684
64MP0002396_abnormal_hematopoietic_system0.79577473
65MP0002019_abnormal_tumor_incidence0.78558871
66MP0000490_abnormal_crypts_of0.78472404
67MP0002998_abnormal_bone_remodeling0.75659233
68MP0002653_abnormal_ependyma_morphology0.73537599
69MP0003786_premature_aging0.73519850
70MP0001919_abnormal_reproductive_system0.68542478
71MP0003075_altered_response_to0.64884338
72MP0003252_abnormal_bile_duct0.64178925
73MP0004130_abnormal_muscle_cell0.62146642
74MP0002102_abnormal_ear_morphology0.62065683
75MP0001764_abnormal_homeostasis0.59967333
76MP0001243_abnormal_dermal_layer0.58012286
77MP0003303_peritoneal_inflammation0.56513174
78MP0002136_abnormal_kidney_physiology0.56387758
79MP0004883_abnormal_blood_vessel0.55526423
80MP0005390_skeleton_phenotype0.52953522
81MP0003806_abnormal_nucleotide_metabolis0.52853481
82MP0002876_abnormal_thyroid_physiology0.52154518
83MP0001765_abnormal_ion_homeostasis0.52004861
84MP0003795_abnormal_bone_structure0.51007993
85MP0009643_abnormal_urine_homeostasis0.50468092
86MP0001501_abnormal_sleep_pattern0.50373774
87MP0009765_abnormal_xenobiotic_induced0.47958251
88MP0000249_abnormal_blood_vessel0.47134651
89MP0003646_muscle_fatigue0.46412439
90MP0001905_abnormal_dopamine_level0.44954215
91MP0003787_abnormal_imprinting0.42572249
92MP0009840_abnormal_foam_cell0.42504748
93MP0002168_other_aberrant_phenotype0.42333773
94MP0008877_abnormal_DNA_methylation0.41863230
95MP0005381_digestive/alimentary_phenotyp0.41243495
96MP0008873_increased_physiological_sensi0.41170277
97MP0005379_endocrine/exocrine_gland_phen0.38250396
98MP0004134_abnormal_chest_morphology0.37543358
99MP0009642_abnormal_blood_homeostasis0.37273889
100MP0000477_abnormal_intestine_morphology0.35288047

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)6.75089142
2Elevated erythrocyte sedimentation rate (HP:0003565)6.70441349
3T lymphocytopenia (HP:0005403)6.38034683
4Abnormality of T cell number (HP:0011839)5.89267626
5Stomatitis (HP:0010280)5.84391912
6Severe combined immunodeficiency (HP:0004430)5.83788002
7IgG deficiency (HP:0004315)5.42710000
8Aplastic anemia (HP:0001915)4.84488285
9Combined immunodeficiency (HP:0005387)4.68072321
10Eczematoid dermatitis (HP:0000976)4.55706847
11Abnormality of T cells (HP:0002843)4.49306982
12Increased IgM level (HP:0003496)4.31990028
13Panhypogammaglobulinemia (HP:0003139)4.18002694
14Hypoproteinemia (HP:0003075)4.16967603
15Recurrent fungal infections (HP:0002841)4.03324309
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.78721717
17Chronic diarrhea (HP:0002028)3.76804979
18Abnormality of the prostate (HP:0008775)3.71920572
19Thyroiditis (HP:0100646)3.65858982
20Chronic mucocutaneous candidiasis (HP:0002728)3.65452704
21Recurrent cutaneous fungal infections (HP:0011370)3.65452704
22Gastrointestinal infarctions (HP:0005244)3.61999136
23Encephalitis (HP:0002383)3.58258489
24Meningitis (HP:0001287)3.57706756
25Myositis (HP:0100614)3.55165312
26Chronic obstructive pulmonary disease (HP:0006510)3.54242926
27Obstructive lung disease (HP:0006536)3.54242926
28Abnormality of eosinophils (HP:0001879)3.53462047
29Recurrent bronchitis (HP:0002837)3.37148370
30IgM deficiency (HP:0002850)3.33113339
31Abnormality of macrophages (HP:0004311)3.25903474
32Leukocytosis (HP:0001974)3.23431477
33Recurrent abscess formation (HP:0002722)3.17908398
34Lymphopenia (HP:0001888)3.17896276
35Recurrent bacterial skin infections (HP:0005406)3.17727985
36Vasculitis (HP:0002633)3.17075295
37Eosinophilia (HP:0001880)3.16789138
38Pulmonary infiltrates (HP:0002113)3.14288289
39Chest pain (HP:0100749)3.09416767
40Pustule (HP:0200039)3.08169249
41Granulocytopenia (HP:0001913)3.06332375
42Abnormality of T cell physiology (HP:0011840)2.98771437
43Hypergammaglobulinemia (HP:0010702)2.97517902
44Mediastinal lymphadenopathy (HP:0100721)2.96375775
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.95204416
46Recurrent viral infections (HP:0004429)2.93404627
47Retrobulbar optic neuritis (HP:0100654)2.88606814
48Optic neuritis (HP:0100653)2.88606814
49Hypoplasia of the thymus (HP:0000778)2.81391079
50Petechiae (HP:0000967)2.75661785
51Orchitis (HP:0100796)2.74302579
52Recurrent skin infections (HP:0001581)2.73042261
53Hemoptysis (HP:0002105)2.71013759
54Agammaglobulinemia (HP:0004432)2.70272313
55B lymphocytopenia (HP:0010976)2.69881734
56Abnormality of B cell number (HP:0010975)2.64549062
57Epistaxis (HP:0000421)2.63782155
58Gangrene (HP:0100758)2.61983934
59Inflammation of the large intestine (HP:0002037)2.51642960
60Joint swelling (HP:0001386)2.51089275
61Pulmonary embolism (HP:0002204)2.49416695
62Lymphoma (HP:0002665)2.42473632
63Increased IgE level (HP:0003212)2.41383110
64Papilledema (HP:0001085)2.37431431
65Gastrointestinal inflammation (HP:0004386)2.29012417
66Pancytopenia (HP:0001876)2.28981533
67Recurrent gram-negative bacterial infections (HP:0005420)2.28947943
68Prolonged bleeding time (HP:0003010)2.28403629
69Abnormality of male internal genitalia (HP:0000022)2.27031470
70Prostate neoplasm (HP:0100787)2.26151996
71Ureteral stenosis (HP:0000071)2.23306318
72Hematochezia (HP:0002573)2.19174922
73Spontaneous hematomas (HP:0007420)2.14085229
74Bronchitis (HP:0012387)2.12790825
75Gingival bleeding (HP:0000225)2.10429726
76Pulmonary fibrosis (HP:0002206)2.09225075
77Acute hepatic failure (HP:0006554)2.08905765
78Autoimmune thrombocytopenia (HP:0001973)2.06611631
79Ureteral obstruction (HP:0006000)2.06609117
80Oral leukoplakia (HP:0002745)2.06217639
81Arterial thrombosis (HP:0004420)2.05907004
82Polyneuropathy (HP:0001271)2.04981503
83Keratoconjunctivitis (HP:0001096)2.04626623
84Keratoconjunctivitis sicca (HP:0001097)2.02587106
85Hypoalbuminemia (HP:0003073)2.00351325
86Abnormal albumin level (HP:0012116)2.00351325
87Neonatal respiratory distress (HP:0002643)1.97672795
88Microcytic anemia (HP:0001935)1.93480377
89Colitis (HP:0002583)1.91890473
90Anorexia (HP:0002039)1.90534351
91Abnormality of the pleura (HP:0002103)1.89596088
92Recurrent otitis media (HP:0000403)1.89524611
93Aplasia/Hypoplasia of the thymus (HP:0010515)1.89045983
94Hypochromic anemia (HP:0001931)1.89039155
95Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87525126
96Skin rash (HP:0000988)1.85678249
97Basal ganglia calcification (HP:0002135)1.85567122
98Amyotrophic lateral sclerosis (HP:0007354)1.85183123
99Urticaria (HP:0001025)1.84395325
100Congenital stationary night blindness (HP:0007642)1.84180292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.22753846
2MAP4K15.21929382
3KDR3.85025229
4TAOK33.14240951
5ZAP702.85377175
6TESK22.83921289
7ITK2.82628132
8RIPK42.44865326
9GRK62.43380847
10TEC2.34142525
11FES2.28794022
12JAK32.17988959
13BTK2.07677553
14TYK22.04842649
15LCK1.92250669
16IKBKE1.88505921
17CSK1.88326729
18SYK1.85794018
19CSF1R1.55924910
20HCK1.51968497
21SCYL21.47375256
22JAK11.46257586
23MARK31.44188372
24NLK1.39646881
25CAMKK21.36585107
26MAP3K111.33902709
27PRKCQ1.31859847
28LYN1.31312082
29IRAK41.27642458
30TNK21.07003344
31BLK1.05850850
32JAK21.04928124
33PASK1.01851713
34PIM11.01084751
35ADRBK20.99431499
36IKBKB0.97179838
37TBK10.96503327
38KIT0.88661080
39FGFR40.86677947
40TLK10.86336370
41ZAK0.84837341
42FYN0.83815658
43CAMKK10.83513851
44TESK10.81390407
45LRRK20.79108971
46STK100.78350228
47MAP3K30.78143564
48SIK20.77146535
49TAOK20.76961670
50MAP3K130.76735936
51SIK30.75154505
52MAP3K100.73205502
53MAP3K140.71576523
54TAOK10.70424103
55GRK70.65921185
56IGF1R0.65106957
57FGFR30.60824289
58MAP2K60.60019670
59MAP3K50.58007560
60BMPR20.57243690
61CLK10.57135077
62CDK190.56385695
63MAPK110.56180136
64PRPF4B0.51331048
65TYRO30.50771291
66FGR0.50683195
67MAP2K30.48322729
68PDGFRB0.46418851
69MAP3K120.44267803
70INSR0.43653391
71FRK0.42655861
72MST40.42084624
73RPS6KA50.39927252
74PIK3CA0.39436752
75TRPM70.36496615
76HIPK20.36089230
77VRK10.34464703
78PDK10.32137512
79VRK20.32097070
80MAP3K10.30043176
81GRK10.28650400
82MAP4K20.28403728
83TIE10.27910487
84ABL10.27217750
85EPHB10.25924848
86ERBB30.25570476
87PIK3CG0.24911065
88EGFR0.22282034
89CDK40.21491941
90MAPK30.20705354
91PRKCH0.20366912
92ROCK10.19660863
93WNK40.18232270
94PRKCD0.17257259
95PTK2B0.17106887
96STK40.14012839
97PRKCA0.13705252
98MYLK0.13641130
99SRC0.13162145
100MAP3K70.12604538

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.98721851
2T cell receptor signaling pathway_Homo sapiens_hsa046604.09653163
3Autoimmune thyroid disease_Homo sapiens_hsa053203.40843399
4Graft-versus-host disease_Homo sapiens_hsa053323.37002735
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.23727038
6Allograft rejection_Homo sapiens_hsa053303.08741417
7Hematopoietic cell lineage_Homo sapiens_hsa046403.04994095
8Antigen processing and presentation_Homo sapiens_hsa046122.85551379
9Measles_Homo sapiens_hsa051622.69401655
10Type I diabetes mellitus_Homo sapiens_hsa049402.30964092
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.99984214
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98261319
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84424819
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.79734422
15Viral myocarditis_Homo sapiens_hsa054161.64034430
16Osteoclast differentiation_Homo sapiens_hsa043801.62592838
17Proteasome_Homo sapiens_hsa030501.59074893
18Malaria_Homo sapiens_hsa051441.54856203
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52461698
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.47700709
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45245782
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38014211
23Leishmaniasis_Homo sapiens_hsa051401.37145250
24Herpes simplex infection_Homo sapiens_hsa051681.36682515
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35627193
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29250677
27Chemokine signaling pathway_Homo sapiens_hsa040621.28117438
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27934116
29B cell receptor signaling pathway_Homo sapiens_hsa046621.23915987
30Rheumatoid arthritis_Homo sapiens_hsa053231.22063307
31Shigellosis_Homo sapiens_hsa051311.17863819
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16983961
33Staphylococcus aureus infection_Homo sapiens_hsa051501.13676972
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13523900
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06019641
36Asthma_Homo sapiens_hsa053100.99296841
37Platelet activation_Homo sapiens_hsa046110.97830642
38TNF signaling pathway_Homo sapiens_hsa046680.85305824
39Influenza A_Homo sapiens_hsa051640.83382806
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82801559
41Tuberculosis_Homo sapiens_hsa051520.81951625
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80918957
43Acute myeloid leukemia_Homo sapiens_hsa052210.77186271
44Pertussis_Homo sapiens_hsa051330.74196582
45Toxoplasmosis_Homo sapiens_hsa051450.73110876
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.72919881
47HTLV-I infection_Homo sapiens_hsa051660.71854925
48Legionellosis_Homo sapiens_hsa051340.68350196
49Ribosome_Homo sapiens_hsa030100.67487580
50Salmonella infection_Homo sapiens_hsa051320.66680597
51Endocytosis_Homo sapiens_hsa041440.64892094
52Epstein-Barr virus infection_Homo sapiens_hsa051690.64251704
53Hepatitis B_Homo sapiens_hsa051610.63457040
54Phototransduction_Homo sapiens_hsa047440.62302809
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60474108
56Viral carcinogenesis_Homo sapiens_hsa052030.59646876
57African trypanosomiasis_Homo sapiens_hsa051430.56790418
58Linoleic acid metabolism_Homo sapiens_hsa005910.54220361
59Olfactory transduction_Homo sapiens_hsa047400.53094360
60Apoptosis_Homo sapiens_hsa042100.53034340
61Oxidative phosphorylation_Homo sapiens_hsa001900.49769483
62Systemic lupus erythematosus_Homo sapiens_hsa053220.49329794
63Hepatitis C_Homo sapiens_hsa051600.48022978
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47057216
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45873245
66Non-small cell lung cancer_Homo sapiens_hsa052230.45619899
67ABC transporters_Homo sapiens_hsa020100.45168905
68Selenocompound metabolism_Homo sapiens_hsa004500.44103083
69Ras signaling pathway_Homo sapiens_hsa040140.42722961
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41373003
71Parkinsons disease_Homo sapiens_hsa050120.40654814
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40110627
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37622089
74VEGF signaling pathway_Homo sapiens_hsa043700.37599782
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36394332
76MAPK signaling pathway_Homo sapiens_hsa040100.35643578
77Arachidonic acid metabolism_Homo sapiens_hsa005900.31372680
78Phagosome_Homo sapiens_hsa041450.31214456
79Salivary secretion_Homo sapiens_hsa049700.30935332
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30045139
81Nitrogen metabolism_Homo sapiens_hsa009100.29685886
82RNA degradation_Homo sapiens_hsa030180.26502647
83Dorso-ventral axis formation_Homo sapiens_hsa043200.25726762
84Ether lipid metabolism_Homo sapiens_hsa005650.25377517
85Pancreatic cancer_Homo sapiens_hsa052120.25334481
86Regulation of autophagy_Homo sapiens_hsa041400.23553223
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22610100
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22235198
89Renin secretion_Homo sapiens_hsa049240.21986383
90Alzheimers disease_Homo sapiens_hsa050100.19081706
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19075517
92Collecting duct acid secretion_Homo sapiens_hsa049660.17724744
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.16627879
94Peroxisome_Homo sapiens_hsa041460.16597561
95Oxytocin signaling pathway_Homo sapiens_hsa049210.14785663
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14159043
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.13858724
98Rap1 signaling pathway_Homo sapiens_hsa040150.13264167
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12658434
100RNA polymerase_Homo sapiens_hsa030200.12542147

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