TRAV8-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)9.33529095
2negative T cell selection (GO:0043383)7.98158578
3negative thymic T cell selection (GO:0045060)7.57467186
4cellular response to interleukin-15 (GO:0071350)7.02493633
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.44769598
6response to interleukin-15 (GO:0070672)6.30488383
7regulation of regulatory T cell differentiation (GO:0045589)6.07135749
8positive regulation of gamma-delta T cell activation (GO:0046645)5.97231916
9thymic T cell selection (GO:0045061)5.83929096
10regulation of T cell tolerance induction (GO:0002664)5.79133499
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.66233304
12negative regulation of cell killing (GO:0031342)5.66233304
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62659465
14positive regulation of tolerance induction (GO:0002645)5.59021676
15T cell selection (GO:0045058)5.50686004
16leukocyte aggregation (GO:0070486)5.39509987
17positive T cell selection (GO:0043368)5.36003371
18regulation of gamma-delta T cell differentiation (GO:0045586)5.26845056
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.14105320
20negative regulation of T cell mediated immunity (GO:0002710)5.05438361
21regulation of isotype switching to IgG isotypes (GO:0048302)5.01172257
22regulation of interleukin-2 biosynthetic process (GO:0045076)5.01162740
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.95500769
24positive thymic T cell selection (GO:0045059)4.93801474
25regulation of gamma-delta T cell activation (GO:0046643)4.79259807
26regulation of tolerance induction (GO:0002643)4.77384542
27activated T cell proliferation (GO:0050798)4.75175423
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.75121697
29antigen processing and presentation of endogenous antigen (GO:0019883)4.61364441
30regulation of B cell receptor signaling pathway (GO:0050855)4.44183753
31T cell migration (GO:0072678)4.40452988
32regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.30609070
33regulation of natural killer cell mediated immunity (GO:0002715)4.30609070
34positive regulation of granulocyte differentiation (GO:0030854)4.28727956
35positive regulation of natural killer cell mediated immunity (GO:0002717)4.22179040
36mast cell activation (GO:0045576)4.16511169
37mucosal-associated lymphoid tissue development (GO:0048537)4.13057066
38Peyers patch development (GO:0048541)4.13057066
39T cell receptor signaling pathway (GO:0050852)4.11754943
40regulation of alpha-beta T cell proliferation (GO:0046640)4.10480154
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.06550619
42hepatocyte apoptotic process (GO:0097284)4.00384225
43positive regulation of T cell mediated cytotoxicity (GO:0001916)3.97351041
44positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.96133223
45regulation of T cell mediated cytotoxicity (GO:0001914)3.93586719
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.93230142
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.85936970
48regulation of leukocyte mediated cytotoxicity (GO:0001910)3.85359536
49antigen receptor-mediated signaling pathway (GO:0050851)3.79072775
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.68177733
51positive regulation of cell killing (GO:0031343)3.66478123
52regulation of B cell differentiation (GO:0045577)3.61984416
53positive regulation of T cell differentiation in thymus (GO:0033089)3.60186317
54mast cell degranulation (GO:0043303)3.51282273
55mast cell activation involved in immune response (GO:0002279)3.51282273
56alpha-beta T cell differentiation (GO:0046632)3.50121813
57activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.48030482
58regulation of cell killing (GO:0031341)3.46561331
59T cell costimulation (GO:0031295)3.45334947
60lymphocyte costimulation (GO:0031294)3.41067909
61regulation of T cell receptor signaling pathway (GO:0050856)3.39303624
62interferon-gamma production (GO:0032609)3.36600480
63antigen processing and presentation via MHC class Ib (GO:0002475)3.36469594
64positive regulation of defense response to virus by host (GO:0002230)3.36010177
65T cell homeostasis (GO:0043029)3.34461519
66positive regulation of interleukin-4 production (GO:0032753)3.32924695
67negative regulation of B cell activation (GO:0050869)3.27396779
68alpha-beta T cell activation (GO:0046631)3.23063654
69T cell differentiation (GO:0030217)3.22844744
70regulation of isotype switching (GO:0045191)3.20966752
71positive regulation of T cell mediated immunity (GO:0002711)3.18851530
72positive regulation of alpha-beta T cell activation (GO:0046635)3.18814735
73positive regulation of humoral immune response (GO:0002922)3.18261118
74positive regulation of isotype switching (GO:0045830)3.16715212
75positive regulation of lymphocyte mediated immunity (GO:0002708)3.16537564
76cellular response to interleukin-4 (GO:0071353)3.15924964
77regulation of alpha-beta T cell activation (GO:0046634)3.15318985
78regulation of interleukin-2 production (GO:0032663)3.15206577
79regulation of chronic inflammatory response (GO:0002676)3.13101011
80negative regulation of leukocyte mediated immunity (GO:0002704)3.12847063
81negative regulation of interleukin-2 production (GO:0032703)3.10768065
82positive regulation of interleukin-2 production (GO:0032743)3.09410359
83germinal center formation (GO:0002467)3.08195319
84myeloid dendritic cell differentiation (GO:0043011)3.07468744
85regulation of T cell mediated immunity (GO:0002709)3.04874618
86chemokine-mediated signaling pathway (GO:0070098)3.04769720
87DNA deamination (GO:0045006)3.04757563
88positive regulation of macrophage differentiation (GO:0045651)3.04222458
89lymphocyte migration (GO:0072676)3.03906074
90CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.03785827
91positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.03619174
92myeloid dendritic cell activation (GO:0001773)3.03006822
93positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.01590132
94negative regulation of adaptive immune response (GO:0002820)3.00779018
95type I interferon signaling pathway (GO:0060337)3.00470358
96cellular response to type I interferon (GO:0071357)3.00470358
97regulation of T cell chemotaxis (GO:0010819)2.99896752
98positive regulation of T cell chemotaxis (GO:0010820)2.99896752
99NIK/NF-kappaB signaling (GO:0038061)2.97965323
100response to type I interferon (GO:0034340)2.97472282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.37714971
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.21911284
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.78424667
4RUNX_20019798_ChIP-Seq_JUKART_Human4.09875423
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.78424548
6MYB_26560356_Chip-Seq_TH2_Human3.61080884
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.58817296
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.40813618
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.29184548
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.24887057
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12565068
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07386689
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.96984380
14MAF_26560356_Chip-Seq_TH1_Human2.95665645
15MYB_26560356_Chip-Seq_TH1_Human2.85536731
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.80554824
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78370128
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71595410
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.56088709
20MAF_26560356_Chip-Seq_TH2_Human2.50114862
21UTX_26944678_Chip-Seq_JUKART_Human2.48286057
22MYC_22102868_ChIP-Seq_BL_Human2.40456904
23GATA3_27048872_Chip-Seq_THYMUS_Human2.26037170
24GATA3_26560356_Chip-Seq_TH2_Human2.04498291
25SPI1_23547873_ChIP-Seq_NB4_Human2.03326381
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00558817
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00378661
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99614299
29VDR_23849224_ChIP-Seq_CD4+_Human1.90401538
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87133856
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.80776162
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80267029
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67994812
34CIITA_25753668_ChIP-Seq_RAJI_Human1.57874129
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56666340
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.53057204
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51511306
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51051475
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48469664
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.47747690
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44721725
42FOXP3_21729870_ChIP-Seq_TREG_Human1.43636026
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34705588
44VDR_21846776_ChIP-Seq_THP-1_Human1.31613035
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30490879
46SPI1_23127762_ChIP-Seq_K562_Human1.25564703
47E2F7_22180533_ChIP-Seq_HELA_Human1.25082755
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.21019973
49TCF7_22412390_ChIP-Seq_EML_Mouse1.17078212
50SCL_19346495_ChIP-Seq_HPC-7_Human1.16364009
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15501979
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15317252
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14872248
54GATA3_26560356_Chip-Seq_TH1_Human1.11222639
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09650791
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.09361811
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09246010
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01101162
59KDM2B_26808549_Chip-Seq_DND41_Human1.00607688
60GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99193631
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98867219
62HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98430951
63PU_27001747_Chip-Seq_BMDM_Mouse0.98182560
64FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94799244
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92373783
66RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91816491
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90427806
68VDR_24763502_ChIP-Seq_THP-1_Human0.89356511
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88443701
70KDM2B_26808549_Chip-Seq_JURKAT_Human0.88293857
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86601974
72PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85948299
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84073716
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83471411
75PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83179632
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81353051
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81189212
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79372207
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77072210
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76915936
81P300_27268052_Chip-Seq_Bcells_Human0.76550011
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76400441
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75962215
84CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75310934
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75220946
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74419215
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74079733
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73528249
89KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73257087
90CTCF_26484167_Chip-Seq_Bcells_Mouse0.72957054
91SA1_27219007_Chip-Seq_Bcells_Human0.72666076
92BCL6_27268052_Chip-Seq_Bcells_Human0.71581663
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71332697
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.71071243
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.70932548
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70615170
97CTCF_21964334_ChIP-Seq_BJAB-B_Human0.69790966
98SMRT_27268052_Chip-Seq_Bcells_Human0.69783293
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69681803
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69309148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.14390028
2MP0005671_abnormal_response_to4.59180593
3MP0009333_abnormal_splenocyte_physiolog4.08505235
4MP0000685_abnormal_immune_system3.56133285
5MP0001835_abnormal_antigen_presentation3.48441201
6MP0001873_stomach_inflammation3.42925973
7MP0003436_decreased_susceptibility_to3.31439683
8MP0001800_abnormal_humoral_immune3.22648786
9MP0001790_abnormal_immune_system3.00378000
10MP0005387_immune_system_phenotype3.00378000
11MP0005000_abnormal_immune_tolerance2.86375547
12MP0000703_abnormal_thymus_morphology2.76555102
13MP0002420_abnormal_adaptive_immunity2.62113319
14MP0002723_abnormal_immune_serum2.59369213
15MP0001819_abnormal_immune_cell2.58304068
16MP0002398_abnormal_bone_marrow2.43155778
17MP0002452_abnormal_antigen_presenting2.40484859
18MP0002166_altered_tumor_susceptibility2.32803828
19MP0002148_abnormal_hypersensitivity_rea2.32320917
20MP0005025_abnormal_response_to2.30619583
21MP0002405_respiratory_system_inflammati2.26597263
22MP0010155_abnormal_intestine_physiology2.25711879
23MP0003300_gastrointestinal_ulcer2.25348567
24MP0009785_altered_susceptibility_to2.21435208
25MP0000716_abnormal_immune_system2.21432765
26MP0003866_abnormal_defecation2.20424040
27MP0002163_abnormal_gland_morphology2.14130395
28MP0003724_increased_susceptibility_to2.06862021
29MP0000689_abnormal_spleen_morphology2.05859998
30MP0002722_abnormal_immune_system2.04372990
31MP0002396_abnormal_hematopoietic_system2.02599903
32MP0005310_abnormal_salivary_gland1.99278433
33MP0004947_skin_inflammation1.98522336
34MP0004381_abnormal_hair_follicle1.97784433
35MP0001348_abnormal_lacrimal_gland1.94944996
36MP0002419_abnormal_innate_immunity1.92482334
37MP0006082_CNS_inflammation1.75823909
38MP0002429_abnormal_blood_cell1.73780457
39MP0002006_tumorigenesis1.72373297
40MP0001845_abnormal_inflammatory_respons1.62019724
41MP0000465_gastrointestinal_hemorrhage1.55343910
42MP0001851_eye_inflammation1.54245688
43MP0001533_abnormal_skeleton_physiology1.47735694
44MP0000490_abnormal_crypts_of1.42426024
45MP0003303_peritoneal_inflammation1.41840257
46MP0005379_endocrine/exocrine_gland_phen1.32520529
47MP0002009_preneoplasia1.31482525
48MP0002277_abnormal_respiratory_mucosa1.29799440
49MP0002138_abnormal_hepatobiliary_system1.28108586
50MP0002933_joint_inflammation1.27441750
51MP0001661_extended_life_span1.26185538
52MP0005464_abnormal_platelet_physiology1.25972227
53MP0005075_abnormal_melanosome_morpholog1.21083620
54MP0008469_abnormal_protein_level1.12867998
55MP0009764_decreased_sensitivity_to1.07657253
56MP0003806_abnormal_nucleotide_metabolis0.98413133
57MP0001663_abnormal_digestive_system0.97763291
58MP0008961_abnormal_basal_metabolism0.97159628
59MP0008057_abnormal_DNA_replication0.96930749
60MP0001853_heart_inflammation0.87876979
61MP0001346_abnormal_lacrimal_gland0.87523581
62MP0003045_fibrosis0.86059354
63MP0003786_premature_aging0.84394517
64MP0002019_abnormal_tumor_incidence0.83670526
65MP0002254_reproductive_system_inflammat0.77994676
66MP0001919_abnormal_reproductive_system0.74573930
67MP0001542_abnormal_bone_strength0.72354025
68MP0003448_altered_tumor_morphology0.70810606
69MP0009763_increased_sensitivity_to0.69330022
70MP0004883_abnormal_blood_vessel0.65474321
71MP0004808_abnormal_hematopoietic_stem0.65466943
72MP0005645_abnormal_hypothalamus_physiol0.65343340
73MP0002693_abnormal_pancreas_physiology0.64861687
74MP0008873_increased_physiological_sensi0.64048998
75MP0000858_altered_metastatic_potential0.61355183
76MP0001216_abnormal_epidermal_layer0.59374076
77MP0000477_abnormal_intestine_morphology0.56554513
78MP0003453_abnormal_keratinocyte_physiol0.54932448
79MP0004742_abnormal_vestibular_system0.54672571
80MP0003172_abnormal_lysosome_physiology0.54477612
81MP0003252_abnormal_bile_duct0.54179722
82MP0005381_digestive/alimentary_phenotyp0.52577723
83MP0001501_abnormal_sleep_pattern0.51695672
84MP0003183_abnormal_peptide_metabolism0.51195553
85MP0002876_abnormal_thyroid_physiology0.51142701
86MP0002998_abnormal_bone_remodeling0.48933014
87MP0001765_abnormal_ion_homeostasis0.48187469
88MP0009765_abnormal_xenobiotic_induced0.48150844
89MP0005390_skeleton_phenotype0.46911265
90MP0005365_abnormal_bile_salt0.46725429
91MP0003959_abnormal_lean_body0.45433757
92MP0006072_abnormal_retinal_apoptosis0.45422880
93MP0001191_abnormal_skin_condition0.45184849
94MP0003795_abnormal_bone_structure0.42093038
95MP0005166_decreased_susceptibility_to0.39294636
96MP0006035_abnormal_mitochondrial_morpho0.39161781
97MP0000609_abnormal_liver_physiology0.38892341
98MP0001986_abnormal_taste_sensitivity0.37887491
99MP0006036_abnormal_mitochondrial_physio0.37641542
100MP0001502_abnormal_circadian_rhythm0.36065151

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.07565148
2T lymphocytopenia (HP:0005403)6.04497218
3Elevated erythrocyte sedimentation rate (HP:0003565)5.84675340
4Abnormality of T cell number (HP:0011839)5.78430443
5Autoimmune hemolytic anemia (HP:0001890)5.77787329
6Severe combined immunodeficiency (HP:0004430)5.52415273
7Chronic mucocutaneous candidiasis (HP:0002728)5.01934945
8Recurrent cutaneous fungal infections (HP:0011370)5.01934945
9IgG deficiency (HP:0004315)4.79825597
10Abnormality of T cells (HP:0002843)4.79049988
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.75753577
12Recurrent fungal infections (HP:0002841)4.44842004
13Combined immunodeficiency (HP:0005387)4.40733273
14Myositis (HP:0100614)4.33324730
15Abnormality of eosinophils (HP:0001879)4.12208830
16Submucous cleft hard palate (HP:0000176)4.00821203
17Panhypogammaglobulinemia (HP:0003139)3.94145624
18Abnormality of T cell physiology (HP:0011840)3.93463910
19Entropion (HP:0000621)3.85804824
20Increased IgM level (HP:0003496)3.68238037
21Pustule (HP:0200039)3.67494215
22Glucose intolerance (HP:0000833)3.66952926
23Chronic diarrhea (HP:0002028)3.60666414
24Recurrent viral infections (HP:0004429)3.56033321
25Thyroiditis (HP:0100646)3.54488259
26Eczematoid dermatitis (HP:0000976)3.54267697
27Encephalitis (HP:0002383)3.47557218
28Hypoplasia of the thymus (HP:0000778)3.43495264
29Gastrointestinal infarctions (HP:0005244)3.35796810
30Recurrent bronchitis (HP:0002837)3.34416490
31Eosinophilia (HP:0001880)3.27727882
32Granulocytopenia (HP:0001913)3.25696530
33Agammaglobulinemia (HP:0004432)3.22869404
34Leukocytosis (HP:0001974)3.22146890
35Pulmonary infiltrates (HP:0002113)3.17237256
36Lymphopenia (HP:0001888)3.12501303
37Recurrent skin infections (HP:0001581)3.08269325
38Abnormality of cells of the lymphoid lineage (HP:0012140)3.03177979
39Optic neuritis (HP:0100653)3.02258763
40Retrobulbar optic neuritis (HP:0100654)3.02258763
41Mediastinal lymphadenopathy (HP:0100721)2.93665893
42Meningitis (HP:0001287)2.86643039
43Keratoconjunctivitis (HP:0001096)2.77190987
44Congenital, generalized hypertrichosis (HP:0004540)2.76379739
45Keratoconjunctivitis sicca (HP:0001097)2.76336387
46Orchitis (HP:0100796)2.74497960
47Vasculitis (HP:0002633)2.69814042
48Joint swelling (HP:0001386)2.67279887
49Abnormal glucose tolerance (HP:0001952)2.65534309
50IgM deficiency (HP:0002850)2.61771241
51Slow saccadic eye movements (HP:0000514)2.52401127
52Autoimmune thrombocytopenia (HP:0001973)2.50447521
53Obstructive lung disease (HP:0006536)2.48653542
54Chronic obstructive pulmonary disease (HP:0006510)2.48653542
55Recurrent abscess formation (HP:0002722)2.44885764
56Ulnar deviation of the wrist (HP:0003049)2.43200687
57Abnormality of macrophages (HP:0004311)2.42467779
58Hypoproteinemia (HP:0003075)2.36011901
59Hypergammaglobulinemia (HP:0010702)2.33323661
60Hemoptysis (HP:0002105)2.32830447
61Recurrent bacterial skin infections (HP:0005406)2.30697817
62Overlapping toe (HP:0001845)2.30158943
63Chest pain (HP:0100749)2.28524655
64Deep palmar crease (HP:0006191)2.22790370
65Lymphoma (HP:0002665)2.20821613
66Hypochromic anemia (HP:0001931)2.20029974
67Abnormality of small intestinal villus morphology (HP:0011472)2.16804607
68Villous atrophy (HP:0011473)2.16804607
69Short nail (HP:0001799)2.09816961
70Colitis (HP:0002583)2.08761480
71Reduced subcutaneous adipose tissue (HP:0003758)2.08665983
72Aplasia/Hypoplasia of the thymus (HP:0010515)2.07086588
73Acrocyanosis (HP:0001063)2.03586119
74Gangrene (HP:0100758)2.02845116
75Ileus (HP:0002595)2.00307753
76B lymphocytopenia (HP:0010976)1.95959326
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95775655
78Inflammation of the large intestine (HP:0002037)1.91149278
79Papilledema (HP:0001085)1.91146627
80Rough bone trabeculation (HP:0100670)1.90478670
81Abnormality of the prostate (HP:0008775)1.89614573
82Hematochezia (HP:0002573)1.88397555
83Papilloma (HP:0012740)1.88080793
84Verrucae (HP:0200043)1.88080793
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84696627
86Increased IgE level (HP:0003212)1.84481700
87Toxemia of pregnancy (HP:0100603)1.82158636
88Bronchitis (HP:0012387)1.80705648
89Ureteral duplication (HP:0000073)1.80682819
90Abnormality of B cell number (HP:0010975)1.80377649
91Gastrointestinal inflammation (HP:0004386)1.78578812
92Abnormality of the fingertips (HP:0001211)1.78361808
93Anorexia (HP:0002039)1.77815212
94Dilatation of the ascending aorta (HP:0005111)1.77688119
95Hypertensive crisis (HP:0100735)1.76884868
96Basal cell carcinoma (HP:0002671)1.76861991
97Keratitis (HP:0000491)1.76806664
98Epiphyseal stippling (HP:0010655)1.74850906
99Neutropenia (HP:0001875)1.74274415
100Arthralgia (HP:0002829)1.73079061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.52525649
2MAP4K14.95346765
3CAMKK23.35363842
4FES2.82104608
5TSSK62.73660035
6GRK62.69732102
7ITK2.40525233
8IKBKE2.34903070
9PASK2.31859033
10TAOK32.16289215
11ZAP702.14476994
12TESK21.98736589
13CLK11.95400926
14CAMKK11.92068849
15TEC1.90005222
16TESK11.79673753
17BTK1.79380895
18CSK1.79004148
19LCK1.74510051
20PRPF4B1.63931893
21MAP3K111.61964426
22TBK11.61268030
23TGFBR21.59297679
24RIPK41.59268745
25TYK21.56925155
26SYK1.38683486
27WNK41.37838574
28IRAK41.35628191
29JAK11.34831626
30HCK1.28056913
31MAP3K141.27451977
32STK381.27328859
33NLK1.23162845
34TNK21.22764232
35JAK31.20335414
36STK101.15838206
37PRKCQ1.15827112
38IKBKB1.12434894
39FGFR41.11122187
40MAP3K121.03934324
41MST41.03475797
42NUAK11.02181692
43TLK11.01260344
44SIK31.00488989
45MAP2K60.96873648
46MARK30.96492263
47LYN0.94619764
48TAOK20.93377247
49MAP2K30.89091352
50SIK20.88696852
51KDR0.87107595
52MAP3K30.78305536
53TAOK10.77887317
54CDK40.77631998
55PIM10.76990010
56STK40.73534496
57JAK20.72936179
58PIK3CG0.69716350
59FGFR30.65104076
60WNK10.64962082
61MAP3K10.64165300
62TYRO30.63827300
63TRIM280.63721308
64IRAK20.61564185
65PRKD20.58770784
66CAMK1D0.57561147
67EPHB10.56885612
68GRK50.56171417
69MAP3K50.54782058
70NEK10.53050721
71MAP3K130.52581526
72MAPK110.50721982
73GRK70.50445220
74CAMK40.48740603
75PRKCH0.45750863
76PDK10.44235141
77SMG10.43283290
78BLK0.43206557
79LRRK20.42803178
80STK390.41287753
81SCYL20.39812724
82FYN0.38926715
83MAP3K100.38180184
84CSF1R0.37357696
85HIPK20.35529551
86MAPKAPK30.33716003
87MAPK120.33665728
88ADRBK20.32991186
89FGFR10.32289695
90BCR0.32165135
91CDK60.31939047
92MAPKAPK20.31305147
93NTRK20.31085746
94RPS6KA60.30971037
95CSNK1G20.28669439
96RPS6KL10.23323567
97RPS6KC10.23323567
98PAK30.22059756
99EPHA30.21985111
100IRAK10.21048230

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.01236472
2T cell receptor signaling pathway_Homo sapiens_hsa046603.92002060
3Autoimmune thyroid disease_Homo sapiens_hsa053203.27017920
4Allograft rejection_Homo sapiens_hsa053303.10058524
5Graft-versus-host disease_Homo sapiens_hsa053323.04571895
6Measles_Homo sapiens_hsa051622.81689169
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.81459489
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.48637567
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46004729
10Antigen processing and presentation_Homo sapiens_hsa046122.39319836
11Type I diabetes mellitus_Homo sapiens_hsa049402.15925808
12Hematopoietic cell lineage_Homo sapiens_hsa046402.03379463
13Osteoclast differentiation_Homo sapiens_hsa043801.91686593
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83921946
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.72898166
16TNF signaling pathway_Homo sapiens_hsa046681.72440240
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.64203362
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.62398395
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60952947
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58203475
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56797461
22B cell receptor signaling pathway_Homo sapiens_hsa046621.52890355
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.52774337
24Chemokine signaling pathway_Homo sapiens_hsa040621.52757627
25Herpes simplex infection_Homo sapiens_hsa051681.46766121
26Non-small cell lung cancer_Homo sapiens_hsa052231.45087191
27Proteasome_Homo sapiens_hsa030501.35871792
28Viral myocarditis_Homo sapiens_hsa054161.35120865
29Acute myeloid leukemia_Homo sapiens_hsa052211.33887712
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31030430
31Hepatitis B_Homo sapiens_hsa051611.19395768
32Apoptosis_Homo sapiens_hsa042101.14915316
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14409078
34Viral carcinogenesis_Homo sapiens_hsa052031.13990278
35Legionellosis_Homo sapiens_hsa051341.09155527
36Epstein-Barr virus infection_Homo sapiens_hsa051691.08814511
37Regulation of autophagy_Homo sapiens_hsa041401.06732707
38Leishmaniasis_Homo sapiens_hsa051401.04033304
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02550033
40VEGF signaling pathway_Homo sapiens_hsa043701.01444363
41Shigellosis_Homo sapiens_hsa051310.96870331
42HTLV-I infection_Homo sapiens_hsa051660.95249548
43Spliceosome_Homo sapiens_hsa030400.94738232
44Influenza A_Homo sapiens_hsa051640.91357329
45Pancreatic cancer_Homo sapiens_hsa052120.90210311
46Toxoplasmosis_Homo sapiens_hsa051450.88866877
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.87809138
48Asthma_Homo sapiens_hsa053100.86415719
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85650610
50Ribosome_Homo sapiens_hsa030100.81996434
51Platelet activation_Homo sapiens_hsa046110.77807339
52African trypanosomiasis_Homo sapiens_hsa051430.76396828
53RNA degradation_Homo sapiens_hsa030180.74520375
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73740553
55Tuberculosis_Homo sapiens_hsa051520.72244086
56Chronic myeloid leukemia_Homo sapiens_hsa052200.70701253
57Prolactin signaling pathway_Homo sapiens_hsa049170.68147353
58Pertussis_Homo sapiens_hsa051330.68091199
59Endocytosis_Homo sapiens_hsa041440.64330614
60Malaria_Homo sapiens_hsa051440.62162964
61Colorectal cancer_Homo sapiens_hsa052100.61333771
62FoxO signaling pathway_Homo sapiens_hsa040680.59813163
63Ether lipid metabolism_Homo sapiens_hsa005650.56030614
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51907487
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51591567
66Hepatitis C_Homo sapiens_hsa051600.51054320
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51043694
68Rheumatoid arthritis_Homo sapiens_hsa053230.49510397
69MAPK signaling pathway_Homo sapiens_hsa040100.49173132
70Prostate cancer_Homo sapiens_hsa052150.45519763
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45414084
72Notch signaling pathway_Homo sapiens_hsa043300.44959395
73Circadian rhythm_Homo sapiens_hsa047100.44920918
74Salmonella infection_Homo sapiens_hsa051320.42969034
75Staphylococcus aureus infection_Homo sapiens_hsa051500.42899326
76Sulfur relay system_Homo sapiens_hsa041220.42728196
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.39910981
78Phototransduction_Homo sapiens_hsa047440.39851845
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39673711
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38071040
81Inositol phosphate metabolism_Homo sapiens_hsa005620.29846213
82Endometrial cancer_Homo sapiens_hsa052130.28865052
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27399354
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25958067
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25634143
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.25215721
87Glioma_Homo sapiens_hsa052140.22897879
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22875976
89Ras signaling pathway_Homo sapiens_hsa040140.21834208
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21419217
91Renal cell carcinoma_Homo sapiens_hsa052110.20356748
92RNA polymerase_Homo sapiens_hsa030200.19924560
93Linoleic acid metabolism_Homo sapiens_hsa005910.18889756
94Peroxisome_Homo sapiens_hsa041460.17995573
95Small cell lung cancer_Homo sapiens_hsa052220.17153854
96Thyroid cancer_Homo sapiens_hsa052160.17080798
97Insulin resistance_Homo sapiens_hsa049310.17006230
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15042076
99mTOR signaling pathway_Homo sapiens_hsa041500.14241488
100One carbon pool by folate_Homo sapiens_hsa006700.13573282

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