TRAV8-6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)7.06352632
2tolerance induction (GO:0002507)6.60210812
3negative T cell selection (GO:0043383)6.13749244
4negative thymic T cell selection (GO:0045060)6.04086207
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.86686481
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.84844911
7cellular response to interleukin-15 (GO:0071350)5.66467941
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.62893058
9negative regulation of cell killing (GO:0031342)5.61554795
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.61554795
11response to interleukin-15 (GO:0070672)5.53470714
12regulation of regulatory T cell differentiation (GO:0045589)5.32597458
13leukocyte aggregation (GO:0070486)5.29158945
14T cell migration (GO:0072678)5.26685936
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.26261942
16regulation of B cell receptor signaling pathway (GO:0050855)5.22462284
17positive regulation of gamma-delta T cell activation (GO:0046645)5.17635500
18regulation of isotype switching to IgG isotypes (GO:0048302)5.07343407
19regulation of B cell differentiation (GO:0045577)4.92727349
20antigen processing and presentation of endogenous antigen (GO:0019883)4.92434409
21thymic T cell selection (GO:0045061)4.83584358
22negative regulation of T cell mediated immunity (GO:0002710)4.82104575
23regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.80224694
24regulation of natural killer cell mediated immunity (GO:0002715)4.80224694
25positive regulation of natural killer cell mediated immunity (GO:0002717)4.74574702
26Peyers patch development (GO:0048541)4.66256770
27mucosal-associated lymphoid tissue development (GO:0048537)4.66256770
28regulation of gamma-delta T cell differentiation (GO:0045586)4.64679203
29positive regulation of immune response to tumor cell (GO:0002839)4.53834813
30regulation of immune response to tumor cell (GO:0002837)4.53834813
31regulation of response to tumor cell (GO:0002834)4.53834813
32positive regulation of response to tumor cell (GO:0002836)4.53834813
33positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.49986560
34regulation of interleukin-5 production (GO:0032674)4.48009817
35T cell selection (GO:0045058)4.47844956
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.40660645
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.39732864
38regulation of T cell tolerance induction (GO:0002664)4.33932478
39mast cell activation (GO:0045576)4.32252259
40positive T cell selection (GO:0043368)4.29642019
41positive thymic T cell selection (GO:0045059)4.25928695
42regulation of leukocyte mediated cytotoxicity (GO:0001910)4.25844469
43regulation of gamma-delta T cell activation (GO:0046643)4.18505151
44negative regulation of lymphocyte mediated immunity (GO:0002707)4.13702874
45positive regulation of tolerance induction (GO:0002645)4.06442747
46positive regulation of T cell mediated cytotoxicity (GO:0001916)4.03779956
47regulation of T cell mediated cytotoxicity (GO:0001914)4.03672222
48regulation of interleukin-2 biosynthetic process (GO:0045076)4.02368990
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.98153922
50positive regulation of cell killing (GO:0031343)3.94207993
51positive regulation of macrophage differentiation (GO:0045651)3.91977957
52natural killer cell differentiation (GO:0001779)3.90014108
53hepatocyte apoptotic process (GO:0097284)3.84344724
54T cell proliferation (GO:0042098)3.83595140
55cellular extravasation (GO:0045123)3.81673110
56regulation of cell killing (GO:0031341)3.81082177
57mast cell degranulation (GO:0043303)3.73194999
58mast cell activation involved in immune response (GO:0002279)3.73194999
59antigen processing and presentation via MHC class Ib (GO:0002475)3.69854362
60regulation of tolerance induction (GO:0002643)3.69526952
61DNA deamination (GO:0045006)3.68319295
62T cell mediated immunity (GO:0002456)3.64297093
63T cell receptor signaling pathway (GO:0050852)3.64206311
64T cell homeostasis (GO:0043029)3.62766582
65interferon-gamma production (GO:0032609)3.61522472
66regulation of T cell receptor signaling pathway (GO:0050856)3.60844567
67positive regulation of granulocyte differentiation (GO:0030854)3.58053972
68NIK/NF-kappaB signaling (GO:0038061)3.55774641
69positive regulation of lymphocyte mediated immunity (GO:0002708)3.55535177
70regulation of alpha-beta T cell proliferation (GO:0046640)3.55256593
71positive regulation of T cell mediated immunity (GO:0002711)3.55126013
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.53874079
73negative regulation of leukocyte mediated immunity (GO:0002704)3.48658488
74positive regulation of interleukin-2 production (GO:0032743)3.47268804
75antigen receptor-mediated signaling pathway (GO:0050851)3.42554005
76necroptotic process (GO:0070266)3.41800245
77lymphocyte migration (GO:0072676)3.40302007
78negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.39018181
79regulation of T cell mediated immunity (GO:0002709)3.38118998
80positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.35122796
81cellular defense response (GO:0006968)3.34931930
82L-alpha-amino acid transmembrane transport (GO:1902475)3.34667462
83regulation of lymphocyte mediated immunity (GO:0002706)3.32524359
84regulation of isotype switching (GO:0045191)3.30816468
85positive regulation of humoral immune response (GO:0002922)3.30008854
86positive regulation of alpha-beta T cell proliferation (GO:0046641)3.29238655
87negative regulation of interleukin-12 production (GO:0032695)3.27556827
88mature B cell differentiation (GO:0002335)3.23126581
89negative regulation of adaptive immune response (GO:0002820)3.21683991
90positive regulation of T cell cytokine production (GO:0002726)3.17075273
91negative regulation of B cell activation (GO:0050869)3.17033625
92alpha-beta T cell differentiation (GO:0046632)3.17025808
93regulation of T cell cytokine production (GO:0002724)3.16198363
94positive regulation of leukocyte mediated immunity (GO:0002705)3.15436658
95negative regulation of immunoglobulin mediated immune response (GO:0002890)3.14077533
96negative regulation of B cell mediated immunity (GO:0002713)3.14077533
97cytidine deamination (GO:0009972)3.12004830
98cytidine metabolic process (GO:0046087)3.12004830
99cytidine catabolic process (GO:0006216)3.12004830
100leukocyte degranulation (GO:0043299)3.10587938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.36247872
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.89594911
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.56996950
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.54771692
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.97584855
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.60159062
7RUNX_20019798_ChIP-Seq_JUKART_Human3.47757363
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47195652
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.43302813
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.40890928
11MYB_26560356_Chip-Seq_TH2_Human3.25757168
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04984978
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.95782129
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.95408542
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76400917
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.75412395
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75237106
18MYB_26560356_Chip-Seq_TH1_Human2.68519870
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60300672
20MAF_26560356_Chip-Seq_TH1_Human2.56763816
21MYC_22102868_ChIP-Seq_BL_Human2.46629368
22GATA3_27048872_Chip-Seq_THYMUS_Human2.19713453
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18872601
24MAF_26560356_Chip-Seq_TH2_Human2.11901718
25SPI1_23547873_ChIP-Seq_NB4_Human2.10509577
26UTX_26944678_Chip-Seq_JUKART_Human2.07528242
27GATA3_26560356_Chip-Seq_TH2_Human2.06659918
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.98169839
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94480850
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89501941
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84101705
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79294027
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68851151
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66740311
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65910090
36VDR_23849224_ChIP-Seq_CD4+_Human1.63779748
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.60117142
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50482315
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50012104
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42050519
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35806356
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29471306
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27385367
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27377066
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24624618
46VDR_21846776_ChIP-Seq_THP-1_Human1.21958247
47SPI1_23127762_ChIP-Seq_K562_Human1.20523700
48SCL_19346495_ChIP-Seq_HPC-7_Human1.18593703
49FOXP3_21729870_ChIP-Seq_TREG_Human1.18498337
50TCF7_22412390_ChIP-Seq_EML_Mouse1.17227611
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15557985
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13531384
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10107868
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09929164
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09696315
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09252173
57PU_27001747_Chip-Seq_BMDM_Mouse1.07050493
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05799620
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.01945220
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00226494
61GATA3_26560356_Chip-Seq_TH1_Human0.97341937
62CIITA_25753668_ChIP-Seq_RAJI_Human0.95527800
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93766975
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93438601
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93368072
66PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92958817
67FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92312646
68KDM2B_26808549_Chip-Seq_DND41_Human0.91548936
69GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90448936
70KDM2B_26808549_Chip-Seq_JURKAT_Human0.90095328
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88946844
72VDR_24763502_ChIP-Seq_THP-1_Human0.88068573
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87214910
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85655443
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85449156
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84314756
77VDR_24787735_ChIP-Seq_THP-1_Human0.83980571
78GABP_17652178_ChIP-ChIP_JURKAT_Human0.83817237
79RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83388914
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82563245
81PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82091249
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81485053
83ELF1_20517297_ChIP-Seq_JURKAT_Human0.79411026
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78966847
85P300_27268052_Chip-Seq_Bcells_Human0.78505600
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77597416
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77591528
88SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77412129
89BCOR_27268052_Chip-Seq_Bcells_Human0.76332774
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75992564
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75114994
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.72962294
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71659435
94ETS1_20019798_ChIP-Seq_JURKAT_Human0.69847657
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69014351
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.68434980
97IRF1_19129219_ChIP-ChIP_H3396_Human0.67735083
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67442124
99SPI1_20517297_ChIP-Seq_HL60_Human0.66886973
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.66215390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.36637013
2MP0003763_abnormal_thymus_physiology4.20698610
3MP0005671_abnormal_response_to4.03238375
4MP0003436_decreased_susceptibility_to3.66447833
5MP0001835_abnormal_antigen_presentation3.63337151
6MP0000685_abnormal_immune_system3.59449707
7MP0001790_abnormal_immune_system3.31628925
8MP0005387_immune_system_phenotype3.31628925
9MP0009333_abnormal_splenocyte_physiolog3.27773177
10MP0005670_abnormal_white_adipose3.13474473
11MP0001800_abnormal_humoral_immune3.13472830
12MP0002163_abnormal_gland_morphology2.89592598
13MP0001873_stomach_inflammation2.80344000
14MP0005000_abnormal_immune_tolerance2.72256171
15MP0002723_abnormal_immune_serum2.54604226
16MP0002420_abnormal_adaptive_immunity2.51864399
17MP0001819_abnormal_immune_cell2.48359354
18MP0002148_abnormal_hypersensitivity_rea2.47814062
19MP0005025_abnormal_response_to2.40668472
20MP0002452_abnormal_antigen_presenting2.30214995
21MP0009785_altered_susceptibility_to2.29641703
22MP0003866_abnormal_defecation2.21862220
23MP0005379_endocrine/exocrine_gland_phen2.21696263
24MP0002398_abnormal_bone_marrow2.20498262
25MP0000703_abnormal_thymus_morphology2.12662162
26MP0003724_increased_susceptibility_to2.10118691
27MP0000716_abnormal_immune_system2.09827962
28MP0008961_abnormal_basal_metabolism2.09544076
29MP0004381_abnormal_hair_follicle1.95745661
30MP0010155_abnormal_intestine_physiology1.95385211
31MP0002419_abnormal_innate_immunity1.94355630
32MP0000689_abnormal_spleen_morphology1.85682777
33MP0002405_respiratory_system_inflammati1.84342296
34MP0006082_CNS_inflammation1.83857768
35MP0002166_altered_tumor_susceptibility1.82696045
36MP0001348_abnormal_lacrimal_gland1.82530933
37MP0002722_abnormal_immune_system1.78378916
38MP0001845_abnormal_inflammatory_respons1.71078540
39MP0004947_skin_inflammation1.65536737
40MP0003300_gastrointestinal_ulcer1.63319652
41MP0002429_abnormal_blood_cell1.61251124
42MP0005310_abnormal_salivary_gland1.45107159
43MP0001851_eye_inflammation1.42623729
44MP0003303_peritoneal_inflammation1.38194223
45MP0001533_abnormal_skeleton_physiology1.37498144
46MP0003045_fibrosis1.36806264
47MP0002277_abnormal_respiratory_mucosa1.34241458
48MP0000465_gastrointestinal_hemorrhage1.32891695
49MP0002006_tumorigenesis1.29372695
50MP0005075_abnormal_melanosome_morpholog1.27871192
51MP0001502_abnormal_circadian_rhythm1.23738231
52MP0005464_abnormal_platelet_physiology1.23047589
53MP0001986_abnormal_taste_sensitivity1.22837033
54MP0002254_reproductive_system_inflammat1.21773343
55MP0002138_abnormal_hepatobiliary_system1.07960081
56MP0008469_abnormal_protein_level1.06327893
57MP0001663_abnormal_digestive_system1.04460704
58MP0002396_abnormal_hematopoietic_system0.98671641
59MP0000490_abnormal_crypts_of0.93480525
60MP0003693_abnormal_embryo_hatching0.90739909
61MP0003172_abnormal_lysosome_physiology0.89334741
62MP0002933_joint_inflammation0.89019553
63MP0002693_abnormal_pancreas_physiology0.86725861
64MP0009764_decreased_sensitivity_to0.85425737
65MP0001853_heart_inflammation0.77996198
66MP0008872_abnormal_physiological_respon0.74299626
67MP0005076_abnormal_cell_differentiation0.72086258
68MP0000015_abnormal_ear_pigmentation0.71882277
69MP0004883_abnormal_blood_vessel0.71045855
70MP0002019_abnormal_tumor_incidence0.68165689
71MP0001666_abnormal_nutrient_absorption0.66879917
72MP0009763_increased_sensitivity_to0.65004239
73MP0003806_abnormal_nucleotide_metabolis0.63666347
74MP0001501_abnormal_sleep_pattern0.58033413
75MP0005381_digestive/alimentary_phenotyp0.55588065
76MP0000477_abnormal_intestine_morphology0.55490470
77MP0001765_abnormal_ion_homeostasis0.55112531
78MP0005448_abnormal_energy_balance0.54643090
79MP0004233_abnormal_muscle_weight0.54384205
80MP0000569_abnormal_digit_pigmentation0.54187033
81MP0002970_abnormal_white_adipose0.51439230
82MP0005645_abnormal_hypothalamus_physiol0.51170612
83MP0008873_increased_physiological_sensi0.50596011
84MP0003959_abnormal_lean_body0.49872996
85MP0005164_abnormal_response_to0.49776453
86MP0001440_abnormal_grooming_behavior0.49143539
87MP0002998_abnormal_bone_remodeling0.45773965
88MP0002132_abnormal_respiratory_system0.45016847
89MP0004808_abnormal_hematopoietic_stem0.44805986
90MP0002136_abnormal_kidney_physiology0.44704877
91MP0005584_abnormal_enzyme/coenzyme_acti0.44522580
92MP0001919_abnormal_reproductive_system0.44069580
93MP0003646_muscle_fatigue0.42757259
94MP0002075_abnormal_coat/hair_pigmentati0.42650689
95MP0005666_abnormal_adipose_tissue0.41518445
96MP0005390_skeleton_phenotype0.41070889
97MP0005166_decreased_susceptibility_to0.39877544
98MP0003448_altered_tumor_morphology0.39812104
99MP0009765_abnormal_xenobiotic_induced0.38748272
100MP0000371_diluted_coat_color0.38722859

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.87032918
2T lymphocytopenia (HP:0005403)5.64239653
3Elevated erythrocyte sedimentation rate (HP:0003565)5.46924082
4Mediastinal lymphadenopathy (HP:0100721)5.46229390
5Abnormality of T cell number (HP:0011839)5.27159999
6Abnormal delayed hypersensitivity skin test (HP:0002963)5.15254648
7Autoimmune hemolytic anemia (HP:0001890)4.89937169
8Papilledema (HP:0001085)4.85092980
9Abnormality of T cells (HP:0002843)4.76436788
10Chronic mucocutaneous candidiasis (HP:0002728)4.57223808
11Recurrent cutaneous fungal infections (HP:0011370)4.57223808
12Recurrent viral infections (HP:0004429)4.49495152
13Oligodactyly (hands) (HP:0001180)4.39973471
14Panhypogammaglobulinemia (HP:0003139)4.39437411
15Abnormality of T cell physiology (HP:0011840)4.35893463
16Recurrent fungal infections (HP:0002841)4.25495861
17IgG deficiency (HP:0004315)4.21288128
18Myositis (HP:0100614)4.07406882
19Pulmonary infiltrates (HP:0002113)4.05080559
20Hypoproteinemia (HP:0003075)3.80134331
21IgM deficiency (HP:0002850)3.75974369
22Retrobulbar optic neuritis (HP:0100654)3.71962337
23Optic neuritis (HP:0100653)3.71962337
24Encephalitis (HP:0002383)3.66687481
25Eczematoid dermatitis (HP:0000976)3.61414819
26Orchitis (HP:0100796)3.48144837
27Severe combined immunodeficiency (HP:0004430)3.42595749
28Gastrointestinal infarctions (HP:0005244)3.41053239
29Lymphopenia (HP:0001888)3.38671909
30Pustule (HP:0200039)3.37104672
31Volvulus (HP:0002580)3.36871216
32Recurrent bronchitis (HP:0002837)3.34428367
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.18143932
34Meningitis (HP:0001287)3.13340224
35Abnormality of eosinophils (HP:0001879)3.10136209
36Recurrent skin infections (HP:0001581)3.05306971
37Agammaglobulinemia (HP:0004432)3.01690592
38Oligodactyly (HP:0012165)2.90998975
39Vasculitis (HP:0002633)2.88983593
40Abnormality of macrophages (HP:0004311)2.88849867
41Chest pain (HP:0100749)2.85005530
42Leukocytosis (HP:0001974)2.84576888
43Acute hepatic failure (HP:0006554)2.83647144
44Recurrent bacterial skin infections (HP:0005406)2.80739337
45Eosinophilia (HP:0001880)2.74393428
46Granulocytopenia (HP:0001913)2.73246719
47Chronic diarrhea (HP:0002028)2.71835035
48Keratoconjunctivitis (HP:0001096)2.68113208
49Combined immunodeficiency (HP:0005387)2.67109182
50Recurrent abscess formation (HP:0002722)2.64898960
51Keratoconjunctivitis sicca (HP:0001097)2.61653981
52Hemoptysis (HP:0002105)2.60866637
53Increased IgM level (HP:0003496)2.53084101
54Arterial thrombosis (HP:0004420)2.49248465
55Chronic obstructive pulmonary disease (HP:0006510)2.45769331
56Obstructive lung disease (HP:0006536)2.45769331
57Diastasis recti (HP:0001540)2.43941884
58Joint swelling (HP:0001386)2.38978068
59Colitis (HP:0002583)2.30990469
60Hypoplastic nipples (HP:0002557)2.29160871
61Blepharitis (HP:0000498)2.27504910
62Aplasia/Hypoplasia of the thymus (HP:0010515)2.22449975
63Hypoplasia of the thymus (HP:0000778)2.22065236
64Global brain atrophy (HP:0002283)2.20049360
65Inflammation of the large intestine (HP:0002037)2.18223664
66Anorexia (HP:0002039)2.17468303
67Hypochromic anemia (HP:0001931)2.16299039
68Amaurosis fugax (HP:0100576)2.14750048
69Verrucae (HP:0200043)2.13781745
70Papilloma (HP:0012740)2.13781745
71Stenosis of the external auditory canal (HP:0000402)2.10116631
72Asplenia (HP:0001746)2.06515357
73Autoimmune thrombocytopenia (HP:0001973)2.05431446
74Gastrointestinal inflammation (HP:0004386)2.05093108
75Episodic fever (HP:0001954)2.04284722
76Chronic otitis media (HP:0000389)2.03030589
77Recurrent sinusitis (HP:0011108)2.01722577
78Bronchitis (HP:0012387)2.00606661
79Lymphoma (HP:0002665)2.00547993
80Gangrene (HP:0100758)2.00370320
81Thyroiditis (HP:0100646)1.99740635
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.99724880
83Testicular atrophy (HP:0000029)1.99004003
84Abnormality of B cell number (HP:0010975)1.98802954
85Villous atrophy (HP:0011473)1.95762724
86Abnormality of small intestinal villus morphology (HP:0011472)1.95762724
87Increased IgE level (HP:0003212)1.94600353
88Abnormality of the renal cortex (HP:0011035)1.92087750
89B lymphocytopenia (HP:0010976)1.91225846
90Pulmonary embolism (HP:0002204)1.88651488
91Spontaneous hematomas (HP:0007420)1.88348641
92Hypochromic microcytic anemia (HP:0004840)1.87046240
93Anteriorly placed anus (HP:0001545)1.79225041
94Supernumerary bones of the axial skeleton (HP:0009144)1.77540157
95Alveolar cell carcinoma (HP:0006519)1.77338067
96Choroideremia (HP:0001139)1.77135865
97Neutropenia (HP:0001875)1.76096682
98Oligodontia (HP:0000677)1.75524223
99Thrombocytosis (HP:0001894)1.74617436
100Viral hepatitis (HP:0006562)1.74165845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.56248385
2MAP4K14.31639137
3MAP2K63.41194292
4LATS12.95345891
5PIK3CG2.86970703
6PRPF4B2.74064023
7ITK2.67502921
8WNK42.53437972
9MST42.52059334
10RIPK42.51446594
11TEC2.48187617
12BMPR22.37261105
13CAMKK22.36970298
14NUAK12.31778670
15ZAP702.13389241
16FES2.08783540
17MAP2K31.96341669
18STK391.90953886
19MAP3K111.90510473
20TNK21.85064984
21IKBKE1.78529919
22TAOK31.76710030
23BTK1.70625463
24TAOK21.64670282
25GRK61.63750789
26FGFR41.63640977
27TAOK11.62305125
28MAP3K31.61399047
29LCK1.59125802
30CAMKK11.56848250
31IRAK41.54618600
32PASK1.53925997
33TYK21.50598143
34JAK31.41068982
35CSK1.33614271
36JAK11.28145153
37SYK1.22470520
38HCK1.20743561
39IKBKB1.19279824
40SIK21.13175345
41TSSK61.10345494
42SIK31.09834120
43WNK11.08174739
44PLK40.96027652
45NLK0.93032114
46TBK10.90988395
47PRKCQ0.88297212
48MARK30.86794687
49SRPK10.86769098
50STK100.86352093
51PRKCH0.85613121
52EPHB10.82580472
53MAP3K140.82465116
54TGFBR20.78700356
55LYN0.78660559
56GRK70.74321741
57SCYL20.73954558
58PDK10.68044543
59JAK20.65428171
60TRPM70.62230022
61FGFR30.59393252
62BRD40.58729341
63CAMK40.58098378
64MAP3K10.58053925
65TLK10.57294302
66BLK0.56947036
67BUB10.52810885
68PIM10.48319444
69EPHA30.48157729
70DYRK1B0.47720554
71MAP3K130.45455267
72OXSR10.41468906
73IRAK10.40991625
74GRK50.40743179
75MAP3K120.40094379
76MAP3K50.39166516
77KIT0.39081788
78NEK60.38584611
79MAPK110.38425835
80CAMK10.38324570
81MARK20.38131576
82TYRO30.37530836
83STK30.37075258
84MAPK120.36807387
85IGF1R0.35642367
86SMG10.32322953
87STK380.31424756
88HIPK20.31198219
89CSF1R0.30941603
90FYN0.30601640
91TESK20.27243356
92ADRBK20.20638079
93CDK40.19950748
94NTRK20.19231996
95MAPKAPK20.19044199
96FGFR10.19002791
97ZAK0.18459212
98MAPK130.17237151
99YES10.16799465
100KDR0.16752405

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.13036332
2Graft-versus-host disease_Homo sapiens_hsa053324.60284497
3T cell receptor signaling pathway_Homo sapiens_hsa046603.81724836
4Antigen processing and presentation_Homo sapiens_hsa046123.06983589
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.06456537
6Allograft rejection_Homo sapiens_hsa053302.97379537
7Autoimmune thyroid disease_Homo sapiens_hsa053202.93023372
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.56502671
9Type I diabetes mellitus_Homo sapiens_hsa049402.28628809
10Measles_Homo sapiens_hsa051622.26492767
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06926052
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03374246
13Asthma_Homo sapiens_hsa053101.96403386
14Hematopoietic cell lineage_Homo sapiens_hsa046401.95740772
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86040088
16Osteoclast differentiation_Homo sapiens_hsa043801.85854285
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82832642
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.80871682
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.80386436
20B cell receptor signaling pathway_Homo sapiens_hsa046621.76926789
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.69072709
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65267195
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62729198
24TNF signaling pathway_Homo sapiens_hsa046681.58742774
25Chemokine signaling pathway_Homo sapiens_hsa040621.52564686
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50070493
27Leishmaniasis_Homo sapiens_hsa051401.48784868
28VEGF signaling pathway_Homo sapiens_hsa043701.38383915
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22111565
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.21108818
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20348177
32Viral myocarditis_Homo sapiens_hsa054161.20179749
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.15780215
34Tuberculosis_Homo sapiens_hsa051521.12619752
35Toxoplasmosis_Homo sapiens_hsa051451.12560320
36Herpes simplex infection_Homo sapiens_hsa051681.11004586
37Acute myeloid leukemia_Homo sapiens_hsa052211.01531226
38Platelet activation_Homo sapiens_hsa046110.97228761
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97179765
40RNA polymerase_Homo sapiens_hsa030200.95847880
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95656670
42Influenza A_Homo sapiens_hsa051640.94638664
43Epstein-Barr virus infection_Homo sapiens_hsa051690.93389580
44Prolactin signaling pathway_Homo sapiens_hsa049170.92187921
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88993490
46Proteasome_Homo sapiens_hsa030500.86127083
47Salmonella infection_Homo sapiens_hsa051320.82701428
48Apoptosis_Homo sapiens_hsa042100.81765878
49Hepatitis B_Homo sapiens_hsa051610.81569351
50Shigellosis_Homo sapiens_hsa051310.79739153
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79526161
52Hepatitis C_Homo sapiens_hsa051600.71607404
53Staphylococcus aureus infection_Homo sapiens_hsa051500.70641913
54Linoleic acid metabolism_Homo sapiens_hsa005910.70175327
55Pertussis_Homo sapiens_hsa051330.69944813
56Non-small cell lung cancer_Homo sapiens_hsa052230.69914859
57HTLV-I infection_Homo sapiens_hsa051660.65357300
58African trypanosomiasis_Homo sapiens_hsa051430.62811670
59Rheumatoid arthritis_Homo sapiens_hsa053230.62685948
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.60591378
61Malaria_Homo sapiens_hsa051440.59193802
62Circadian rhythm_Homo sapiens_hsa047100.55586848
63Regulation of autophagy_Homo sapiens_hsa041400.54950181
64Viral carcinogenesis_Homo sapiens_hsa052030.51265480
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49405862
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47640921
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47494714
68Legionellosis_Homo sapiens_hsa051340.47324341
69Colorectal cancer_Homo sapiens_hsa052100.45027902
70Ether lipid metabolism_Homo sapiens_hsa005650.40109048
71MAPK signaling pathway_Homo sapiens_hsa040100.39977788
72GnRH signaling pathway_Homo sapiens_hsa049120.38969212
73Endocytosis_Homo sapiens_hsa041440.38458491
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38177407
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37804245
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.37503140
77Pancreatic cancer_Homo sapiens_hsa052120.36194385
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33428519
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31844267
80RNA degradation_Homo sapiens_hsa030180.31840291
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31427768
82FoxO signaling pathway_Homo sapiens_hsa040680.29141994
83Spliceosome_Homo sapiens_hsa030400.28904264
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23168226
85Choline metabolism in cancer_Homo sapiens_hsa052310.21234636
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.20561643
87Arachidonic acid metabolism_Homo sapiens_hsa005900.19919036
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.19751429
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.19150224
90HIF-1 signaling pathway_Homo sapiens_hsa040660.18609278
91Inositol phosphate metabolism_Homo sapiens_hsa005620.18372682
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18224201
93Ras signaling pathway_Homo sapiens_hsa040140.16191770
94Notch signaling pathway_Homo sapiens_hsa043300.15626249
95Oxytocin signaling pathway_Homo sapiens_hsa049210.15323999
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15253428
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15063138
98cAMP signaling pathway_Homo sapiens_hsa040240.13485475
99Ovarian steroidogenesis_Homo sapiens_hsa049130.11785317
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11222284

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