

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of tolerance induction (GO:0002643) | 9.62516611 |
| 2 | signal complex assembly (GO:0007172) | 9.10125628 |
| 3 | thymic T cell selection (GO:0045061) | 8.87781785 |
| 4 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 8.80306871 |
| 5 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 8.75063422 |
| 6 | DNA deamination (GO:0045006) | 8.13462512 |
| 7 | T cell selection (GO:0045058) | 7.63262676 |
| 8 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.22798713 |
| 9 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 7.02093355 |
| 10 | positive thymic T cell selection (GO:0045059) | 6.92735343 |
| 11 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 6.81267097 |
| 12 | T cell costimulation (GO:0031295) | 6.76179874 |
| 13 | interferon-gamma production (GO:0032609) | 6.71071562 |
| 14 | lymphocyte costimulation (GO:0031294) | 6.63959827 |
| 15 | positive T cell selection (GO:0043368) | 6.63830414 |
| 16 | regulation of alpha-beta T cell proliferation (GO:0046640) | 6.53414246 |
| 17 | T cell receptor signaling pathway (GO:0050852) | 6.40958521 |
| 18 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.37509414 |
| 19 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.37509414 |
| 20 | leukocyte aggregation (GO:0070486) | 6.35629359 |
| 21 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.22032834 |
| 22 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 6.01350856 |
| 23 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 6.01350856 |
| 24 | positive regulation of interleukin-4 production (GO:0032753) | 5.98147270 |
| 25 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.83250829 |
| 26 | regulation of natural killer cell mediated immunity (GO:0002715) | 5.81217798 |
| 27 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 5.81217798 |
| 28 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.75226330 |
| 29 | negative regulation of cell killing (GO:0031342) | 5.75226330 |
| 30 | cellular response to interleukin-15 (GO:0071350) | 5.68893316 |
| 31 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.64766386 |
| 32 | regulation of gamma-delta T cell activation (GO:0046643) | 5.50937647 |
| 33 | antigen receptor-mediated signaling pathway (GO:0050851) | 5.45371211 |
| 34 | regulation of lymphocyte chemotaxis (GO:1901623) | 5.39382013 |
| 35 | response to interleukin-15 (GO:0070672) | 5.37872972 |
| 36 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.27516727 |
| 37 | positive regulation of calcium-mediated signaling (GO:0050850) | 5.23035518 |
| 38 | regulation of interleukin-4 production (GO:0032673) | 5.22616557 |
| 39 | negative regulation by host of viral transcription (GO:0043922) | 5.04760277 |
| 40 | T cell migration (GO:0072678) | 5.00398977 |
| 41 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.95535210 |
| 42 | positive regulation of interleukin-2 production (GO:0032743) | 4.77185116 |
| 43 | positive regulation of response to tumor cell (GO:0002836) | 4.75258326 |
| 44 | positive regulation of immune response to tumor cell (GO:0002839) | 4.75258326 |
| 45 | regulation of immune response to tumor cell (GO:0002837) | 4.75258326 |
| 46 | regulation of response to tumor cell (GO:0002834) | 4.75258326 |
| 47 | pyrimidine nucleoside catabolic process (GO:0046135) | 4.73016467 |
| 48 | mast cell activation (GO:0045576) | 4.72805990 |
| 49 | lymphocyte chemotaxis (GO:0048247) | 4.70853542 |
| 50 | positive regulation of B cell differentiation (GO:0045579) | 4.63331912 |
| 51 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.60384850 |
| 52 | negative regulation of viral genome replication (GO:0045071) | 4.59108891 |
| 53 | negative regulation of T cell apoptotic process (GO:0070233) | 4.45929161 |
| 54 | negative regulation of interleukin-12 production (GO:0032695) | 4.42841073 |
| 55 | eosinophil chemotaxis (GO:0048245) | 4.41310073 |
| 56 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.38524923 |
| 57 | cytolysis (GO:0019835) | 4.32072796 |
| 58 | activated T cell proliferation (GO:0050798) | 4.32068334 |
| 59 | homeostasis of number of cells within a tissue (GO:0048873) | 4.30349881 |
| 60 | positive regulation of lymphocyte migration (GO:2000403) | 4.29637463 |
| 61 | regulation of B cell differentiation (GO:0045577) | 4.29171987 |
| 62 | sequestering of actin monomers (GO:0042989) | 4.27970365 |
| 63 | positive regulation of interleukin-8 secretion (GO:2000484) | 4.15443500 |
| 64 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.14876311 |
| 65 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 4.14814586 |
| 66 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 4.11654880 |
| 67 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 4.08003331 |
| 68 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.99126997 |
| 69 | eosinophil migration (GO:0072677) | 3.96462739 |
| 70 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.89042713 |
| 71 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.79227259 |
| 72 | positive regulation of defense response to virus by host (GO:0002230) | 3.77089083 |
| 73 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.74822487 |
| 74 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 3.72679232 |
| 75 | lymph node development (GO:0048535) | 3.72535934 |
| 76 | modulation by host of symbiont transcription (GO:0052472) | 3.70558117 |
| 77 | modulation by host of viral transcription (GO:0043921) | 3.70558117 |
| 78 | positive regulation of cell killing (GO:0031343) | 3.69026552 |
| 79 | negative regulation of viral transcription (GO:0032897) | 3.66133009 |
| 80 | T cell activation (GO:0042110) | 3.64391714 |
| 81 | positive regulation of T cell chemotaxis (GO:0010820) | 3.63370031 |
| 82 | regulation of T cell chemotaxis (GO:0010819) | 3.63370031 |
| 83 | actin nucleation (GO:0045010) | 3.62818646 |
| 84 | regulation of calcium-mediated signaling (GO:0050848) | 3.62508101 |
| 85 | regulation of response to interferon-gamma (GO:0060330) | 3.61363387 |
| 86 | regulation of interleukin-2 production (GO:0032663) | 3.58378045 |
| 87 | regulation of cell killing (GO:0031341) | 3.57806914 |
| 88 | positive regulation of granulocyte differentiation (GO:0030854) | 3.57749721 |
| 89 | regulation of viral genome replication (GO:0045069) | 3.57185090 |
| 90 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.57154636 |
| 91 | positive regulation of humoral immune response (GO:0002922) | 3.55953880 |
| 92 | regulation of interleukin-1 beta secretion (GO:0050706) | 3.51218528 |
| 93 | positive regulation of interleukin-1 secretion (GO:0050716) | 3.50875493 |
| 94 | modulation of transcription in other organism involved in symbiotic interaction (GO:0052312) | 3.48780435 |
| 95 | negative regulation of viral process (GO:0048525) | 3.45188828 |
| 96 | negative regulation of T cell mediated immunity (GO:0002710) | 3.44557722 |
| 97 | regulation of lymphocyte migration (GO:2000401) | 3.43676458 |
| 98 | T cell differentiation (GO:0030217) | 3.43405341 |
| 99 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.42893403 |
| 100 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.40457284 |
| 101 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.39307980 |
| 102 | DNA demethylation (GO:0080111) | 3.35441158 |
| 103 | regulation of regulatory T cell differentiation (GO:0045589) | 3.33362898 |
| 104 | positive regulation of T cell activation (GO:0050870) | 3.32476622 |
| 105 | positive regulation of alpha-beta T cell activation (GO:0046635) | 3.30779766 |
| 106 | leukocyte cell-cell adhesion (GO:0007159) | 3.27098990 |
| 107 | tolerance induction (GO:0002507) | 3.26308855 |
| 108 | macrophage chemotaxis (GO:0048246) | 3.25637201 |
| 109 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.20427482 |
| 110 | B cell receptor signaling pathway (GO:0050853) | 3.19252429 |
| 111 | positive regulation of interferon-gamma production (GO:0032729) | 3.17198737 |
| 112 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 3.16037849 |
| 113 | regulation of T cell activation (GO:0050863) | 3.13802481 |
| 114 | mast cell degranulation (GO:0043303) | 3.11941083 |
| 115 | mast cell activation involved in immune response (GO:0002279) | 3.11941083 |
| 116 | regulation of alpha-beta T cell activation (GO:0046634) | 3.10153556 |
| 117 | regulation of interleukin-1 secretion (GO:0050704) | 3.09772848 |
| 118 | positive regulation of interleukin-1 beta production (GO:0032731) | 3.08960851 |
| 119 | immunoglobulin mediated immune response (GO:0016064) | 3.07880407 |
| 120 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.06901687 |
| 121 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 3.02913625 |
| 122 | positive regulation of B cell mediated immunity (GO:0002714) | 3.02171637 |
| 123 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.02171637 |
| 124 | regulation of defense response to virus by virus (GO:0050690) | 3.00786941 |
| 125 | positive regulation of macrophage differentiation (GO:0045651) | 2.99374479 |
| 126 | T cell mediated immunity (GO:0002456) | 2.98869611 |
| 127 | cellular response to interleukin-4 (GO:0071353) | 2.98708541 |
| 128 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.98367201 |
| 129 | Peyers patch development (GO:0048541) | 2.98367201 |
| 130 | regulation of immunoglobulin mediated immune response (GO:0002889) | 2.96610927 |
| 131 | lymphocyte migration (GO:0072676) | 2.94398190 |
| 132 | alpha-beta T cell differentiation (GO:0046632) | 2.93638464 |
| 133 | regulation of chemokine-mediated signaling pathway (GO:0070099) | 2.92383336 |
| 134 | regulation of protein heterodimerization activity (GO:0043497) | 2.91053530 |
| 135 | T cell homeostasis (GO:0043029) | 2.90713549 |
| 136 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.89055348 |
| 137 | positive regulation of T cell proliferation (GO:0042102) | 2.88816086 |
| 138 | cellular defense response (GO:0006968) | 2.88000155 |
| 139 | regulation of B cell mediated immunity (GO:0002712) | 2.85898158 |
| 140 | alpha-beta T cell activation (GO:0046631) | 2.80220583 |
| 141 | ribosomal small subunit assembly (GO:0000028) | 2.80060855 |
| 142 | positive regulation of lamellipodium assembly (GO:0010592) | 2.77662904 |
| 143 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 2.77194264 |
| 144 | positive regulation of lymphocyte activation (GO:0051251) | 2.72636770 |
| 145 | regulation of T cell tolerance induction (GO:0002664) | 13.2289449 |
| 146 | negative T cell selection (GO:0043383) | 11.6292693 |
| 147 | cytidine metabolic process (GO:0046087) | 11.5463831 |
| 148 | cytidine catabolic process (GO:0006216) | 11.5463831 |
| 149 | cytidine deamination (GO:0009972) | 11.5463831 |
| 150 | negative thymic T cell selection (GO:0045060) | 11.4589270 |
| 151 | positive regulation of tolerance induction (GO:0002645) | 10.9149845 |
| 152 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 10.5356624 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 7.73223433 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 7.02994320 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.17334696 |
| 4 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 4.10732446 |
| 5 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.06456810 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.04009482 |
| 7 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.99863702 |
| 8 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.88379278 |
| 9 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.57531712 |
| 10 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.51690160 |
| 11 | MYB_26560356_Chip-Seq_TH2_Human | 3.48923465 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.37780533 |
| 13 | MYC_22102868_ChIP-Seq_BL_Human | 3.30543781 |
| 14 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.19382498 |
| 15 | UTX_26944678_Chip-Seq_JUKART_Human | 3.05716321 |
| 16 | MAF_26560356_Chip-Seq_TH1_Human | 3.02500207 |
| 17 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.89513725 |
| 18 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.80965117 |
| 19 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.74421500 |
| 20 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.71091985 |
| 21 | MYB_26560356_Chip-Seq_TH1_Human | 2.65045263 |
| 22 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.49560108 |
| 23 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.44289380 |
| 24 | MAF_26560356_Chip-Seq_TH2_Human | 2.31274005 |
| 25 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.12179039 |
| 26 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.00413540 |
| 27 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.99470691 |
| 28 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.98187208 |
| 29 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.87301548 |
| 30 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.81644826 |
| 31 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.81351022 |
| 32 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.79366470 |
| 33 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.77793984 |
| 34 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.76478398 |
| 35 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.65731713 |
| 36 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.65307298 |
| 37 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.65287642 |
| 38 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.65218398 |
| 39 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63428412 |
| 40 | SPI1_23127762_ChIP-Seq_K562_Human | 1.63414704 |
| 41 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.63211245 |
| 42 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.62981619 |
| 43 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.62800377 |
| 44 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.60925611 |
| 45 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.60094230 |
| 46 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.59962709 |
| 47 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.56691376 |
| 48 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.56148989 |
| 49 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.55281453 |
| 50 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.50456804 |
| 51 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.48681666 |
| 52 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.47988186 |
| 53 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.46484202 |
| 54 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.36699806 |
| 55 | GATA3_26560356_Chip-Seq_TH2_Human | 1.34317780 |
| 56 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.32110006 |
| 57 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.30668666 |
| 58 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.30358012 |
| 59 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.29350493 |
| 60 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28529973 |
| 61 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.21211931 |
| 62 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.19568519 |
| 63 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.19041459 |
| 64 | FLI1_21867929_ChIP-Seq_CD8_Mouse | 1.17694170 |
| 65 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.16438264 |
| 66 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.13975121 |
| 67 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.12230162 |
| 68 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.09741647 |
| 69 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.08172286 |
| 70 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.07553836 |
| 71 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.07381902 |
| 72 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05707948 |
| 73 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.05517052 |
| 74 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.04986888 |
| 75 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.03423522 |
| 76 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.03201099 |
| 77 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.01827925 |
| 78 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00300200 |
| 79 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.99995649 |
| 80 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.99883435 |
| 81 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.98898366 |
| 82 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.97740316 |
| 83 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.96068479 |
| 84 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.95664019 |
| 85 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93664385 |
| 86 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.93377435 |
| 87 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.93115539 |
| 88 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.91966599 |
| 89 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.88938174 |
| 90 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.88406389 |
| 91 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.88397474 |
| 92 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.88263492 |
| 93 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88062509 |
| 94 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87132174 |
| 95 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.86820971 |
| 96 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.84850326 |
| 97 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.83758196 |
| 98 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.83370483 |
| 99 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83259147 |
| 100 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.82816685 |
| 101 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.82645502 |
| 102 | GATA1_22025678_ChIP-Seq_K562_Human | 0.82068005 |
| 103 | GATA3_26560356_Chip-Seq_TH1_Human | 0.81897105 |
| 104 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.81666772 |
| 105 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.81395632 |
| 106 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.79591927 |
| 107 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.77740903 |
| 108 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.76615220 |
| 109 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.76222203 |
| 110 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.76066316 |
| 111 | P300_27268052_Chip-Seq_Bcells_Human | 0.73249931 |
| 112 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.71946488 |
| 113 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.71823161 |
| 114 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.69689853 |
| 115 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.69245049 |
| 116 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.69060713 |
| 117 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.66850929 |
| 118 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.66290305 |
| 119 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.66252327 |
| 120 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.65629648 |
| 121 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 0.65063135 |
| 122 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.62032809 |
| 123 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.58577821 |
| 124 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.58577821 |
| 125 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.57076999 |
| 126 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.56669921 |
| 127 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.56235347 |
| 128 | SA1_27219007_Chip-Seq_Bcells_Human | 0.56178683 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 6.75252884 |
| 2 | MP0003763_abnormal_thymus_physiology | 5.94618737 |
| 3 | MP0006082_CNS_inflammation | 3.58968760 |
| 4 | MP0003724_increased_susceptibility_to | 3.22978916 |
| 5 | MP0002420_abnormal_adaptive_immunity | 3.18310942 |
| 6 | MP0002933_joint_inflammation | 3.15054557 |
| 7 | MP0001800_abnormal_humoral_immune | 3.14121323 |
| 8 | MP0000703_abnormal_thymus_morphology | 3.12811063 |
| 9 | MP0001819_abnormal_immune_cell | 3.08811043 |
| 10 | MP0005000_abnormal_immune_tolerance | 3.00993595 |
| 11 | MP0002398_abnormal_bone_marrow | 2.96166394 |
| 12 | MP0009333_abnormal_splenocyte_physiolog | 2.94303442 |
| 13 | MP0002723_abnormal_immune_serum | 2.74028678 |
| 14 | MP0000685_abnormal_immune_system | 2.71449497 |
| 15 | MP0002405_respiratory_system_inflammati | 2.59517514 |
| 16 | MP0001835_abnormal_antigen_presentation | 2.59495673 |
| 17 | MP0000716_abnormal_immune_system | 2.57980036 |
| 18 | MP0009785_altered_susceptibility_to | 2.56656806 |
| 19 | MP0002722_abnormal_immune_system | 2.53663043 |
| 20 | MP0002166_altered_tumor_susceptibility | 2.53474748 |
| 21 | MP0005025_abnormal_response_to | 2.53268060 |
| 22 | MP0001790_abnormal_immune_system | 2.50570194 |
| 23 | MP0005387_immune_system_phenotype | 2.50570194 |
| 24 | MP0002452_abnormal_antigen_presenting | 2.45880908 |
| 25 | MP0003436_decreased_susceptibility_to | 2.43911475 |
| 26 | MP0000689_abnormal_spleen_morphology | 2.40897252 |
| 27 | MP0004947_skin_inflammation | 2.20202981 |
| 28 | MP0002006_tumorigenesis | 2.08778779 |
| 29 | MP0000858_altered_metastatic_potential | 2.08683409 |
| 30 | MP0002429_abnormal_blood_cell | 2.03795722 |
| 31 | MP0002277_abnormal_respiratory_mucosa | 1.98583000 |
| 32 | MP0000569_abnormal_digit_pigmentation | 1.89070446 |
| 33 | MP0003866_abnormal_defecation | 1.86694525 |
| 34 | MP0002419_abnormal_innate_immunity | 1.78978031 |
| 35 | MP0004381_abnormal_hair_follicle | 1.72935451 |
| 36 | MP0001845_abnormal_inflammatory_respons | 1.64248916 |
| 37 | MP0002148_abnormal_hypersensitivity_rea | 1.62671161 |
| 38 | MP0010155_abnormal_intestine_physiology | 1.59156017 |
| 39 | MP0004510_myositis | 1.56845514 |
| 40 | MP0005464_abnormal_platelet_physiology | 1.55833618 |
| 41 | MP0003300_gastrointestinal_ulcer | 1.50962558 |
| 42 | MP0003448_altered_tumor_morphology | 1.46179144 |
| 43 | MP0001851_eye_inflammation | 1.45790189 |
| 44 | MP0002396_abnormal_hematopoietic_system | 1.45640875 |
| 45 | MP0003045_fibrosis | 1.43725418 |
| 46 | MP0001533_abnormal_skeleton_physiology | 1.36336405 |
| 47 | MP0005075_abnormal_melanosome_morpholog | 1.24499969 |
| 48 | MP0003303_peritoneal_inflammation | 1.21043335 |
| 49 | MP0009763_increased_sensitivity_to | 1.16176750 |
| 50 | MP0002876_abnormal_thyroid_physiology | 1.16131296 |
| 51 | MP0001873_stomach_inflammation | 1.14109590 |
| 52 | MP0001958_emphysema | 1.13873786 |
| 53 | MP0002163_abnormal_gland_morphology | 1.13373225 |
| 54 | MP0002019_abnormal_tumor_incidence | 1.10725104 |
| 55 | MP0001299_abnormal_eye_distance/ | 1.08270053 |
| 56 | MP0004147_increased_porphyrin_level | 1.07183295 |
| 57 | MP0006054_spinal_hemorrhage | 1.06979671 |
| 58 | MP0002877_abnormal_melanocyte_morpholog | 1.04852222 |
| 59 | MP0002998_abnormal_bone_remodeling | 1.03863499 |
| 60 | MP0008877_abnormal_DNA_methylation | 1.02624770 |
| 61 | MP0000920_abnormal_myelination | 1.02152250 |
| 62 | MP0008469_abnormal_protein_level | 0.98320879 |
| 63 | MP0010234_abnormal_vibrissa_follicle | 0.97264401 |
| 64 | MP0000604_amyloidosis | 0.94245147 |
| 65 | MP0008260_abnormal_autophagy | 0.90515723 |
| 66 | MP0003786_premature_aging | 0.87828709 |
| 67 | MP0003279_aneurysm | 0.87691017 |
| 68 | MP0004808_abnormal_hematopoietic_stem | 0.87511600 |
| 69 | MP0001853_heart_inflammation | 0.86703041 |
| 70 | MP0002132_abnormal_respiratory_system | 0.86594252 |
| 71 | MP0005023_abnormal_wound_healing | 0.85365517 |
| 72 | MP0005360_urolithiasis | 0.83088885 |
| 73 | MP0000609_abnormal_liver_physiology | 0.76256772 |
| 74 | MP0005408_hypopigmentation | 0.74921450 |
| 75 | MP0005058_abnormal_lysosome_morphology | 0.74433054 |
| 76 | MP0000490_abnormal_crypts_of | 0.73833186 |
| 77 | MP0001348_abnormal_lacrimal_gland | 0.73219055 |
| 78 | MP0009765_abnormal_xenobiotic_induced | 0.73034063 |
| 79 | MP0005310_abnormal_salivary_gland | 0.72890207 |
| 80 | MP0005166_decreased_susceptibility_to | 0.72543792 |
| 81 | MP0002136_abnormal_kidney_physiology | 0.68032371 |
| 82 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.65165633 |
| 83 | MP0000465_gastrointestinal_hemorrhage | 0.63624023 |
| 84 | MP0000249_abnormal_blood_vessel | 0.63399938 |
| 85 | MP0004145_abnormal_muscle_electrophysio | 0.62827752 |
| 86 | MP0008873_increased_physiological_sensi | 0.61946512 |
| 87 | MP0003329_amyloid_beta_deposits | 0.60390560 |
| 88 | MP0001243_abnormal_dermal_layer | 0.60126870 |
| 89 | MP0009764_decreased_sensitivity_to | 0.59378120 |
| 90 | MP0001986_abnormal_taste_sensitivity | 0.58588622 |
| 91 | MP0001919_abnormal_reproductive_system | 0.58526685 |
| 92 | MP0002083_premature_death | 0.56352326 |
| 93 | MP0002693_abnormal_pancreas_physiology | 0.56331860 |
| 94 | MP0002138_abnormal_hepatobiliary_system | 0.55721897 |
| 95 | MP0001188_hyperpigmentation | 0.54469958 |
| 96 | MP0008961_abnormal_basal_metabolism | 0.53599212 |
| 97 | MP0000477_abnormal_intestine_morphology | 0.53531650 |
| 98 | MP0000613_abnormal_salivary_gland | 0.53328305 |
| 99 | MP0001191_abnormal_skin_condition | 0.50851927 |
| 100 | MP0009840_abnormal_foam_cell | 0.50097413 |
| 101 | MP0008569_lethality_at_weaning | 0.50071975 |
| 102 | MP0004957_abnormal_blastocyst_morpholog | 0.49143726 |
| 103 | MP0004742_abnormal_vestibular_system | 0.49073163 |
| 104 | MP0010352_gastrointestinal_tract_polyps | 0.48996732 |
| 105 | MP0003172_abnormal_lysosome_physiology | 0.48829268 |
| 106 | MP0000372_irregular_coat_pigmentation | 0.47949197 |
| 107 | MP0002009_preneoplasia | 0.47922341 |
| 108 | MP0000639_abnormal_adrenal_gland | 0.47642459 |
| 109 | MP0005174_abnormal_tail_pigmentation | 0.47395146 |
| 110 | MP0001501_abnormal_sleep_pattern | 0.46469925 |
| 111 | MP0004859_abnormal_synaptic_plasticity | 0.46285650 |
| 112 | MP0009643_abnormal_urine_homeostasis | 0.45906355 |
| 113 | MP0002095_abnormal_skin_pigmentation | 0.45654041 |
| 114 | MP0005165_increased_susceptibility_to | 0.45422895 |
| 115 | MP0005451_abnormal_body_composition | 0.45213334 |
| 116 | MP0003795_abnormal_bone_structure | 0.45160397 |
| 117 | MP0003075_altered_response_to | 0.44642437 |
| 118 | MP0003633_abnormal_nervous_system | 0.44086019 |
| 119 | MP0000598_abnormal_liver_morphology | 0.43635057 |
| 120 | MP0000015_abnormal_ear_pigmentation | 0.43500213 |
| 121 | MP0005390_skeleton_phenotype | 0.42990186 |
| 122 | MP0002168_other_aberrant_phenotype | 0.42206284 |
| 123 | MP0001663_abnormal_digestive_system | 0.41572177 |
| 124 | MP0001661_extended_life_span | 0.39532766 |
| 125 | MP0005379_endocrine/exocrine_gland_phen | 0.39379918 |
| 126 | MP0005397_hematopoietic_system_phenotyp | 0.37886325 |
| 127 | MP0001545_abnormal_hematopoietic_system | 0.37886325 |
| 128 | MP0003183_abnormal_peptide_metabolism | 0.37357360 |
| 129 | MP0003191_abnormal_cellular_cholesterol | 0.36780045 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 9.53028637 |
| 2 | Abnormality of T cell number (HP:0011839) | 9.11951293 |
| 3 | Aplastic anemia (HP:0001915) | 7.60719028 |
| 4 | Elevated erythrocyte sedimentation rate (HP:0003565) | 7.00116263 |
| 5 | Combined immunodeficiency (HP:0005387) | 6.98285134 |
| 6 | Severe combined immunodeficiency (HP:0004430) | 6.48062423 |
| 7 | Eczematoid dermatitis (HP:0000976) | 5.83397792 |
| 8 | Abnormality of T cells (HP:0002843) | 5.45031276 |
| 9 | Lymphopenia (HP:0001888) | 4.94921537 |
| 10 | Joint swelling (HP:0001386) | 4.85851573 |
| 11 | Autoimmune hemolytic anemia (HP:0001890) | 4.76574837 |
| 12 | Panhypogammaglobulinemia (HP:0003139) | 4.76180912 |
| 13 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 4.71676930 |
| 14 | Nasal polyposis (HP:0100582) | 4.56541826 |
| 15 | Stomatitis (HP:0010280) | 4.54600581 |
| 16 | Chronic otitis media (HP:0000389) | 4.53561139 |
| 17 | Recurrent viral infections (HP:0004429) | 4.50296382 |
| 18 | Recurrent bronchitis (HP:0002837) | 4.24476635 |
| 19 | Recurrent otitis media (HP:0000403) | 4.12304988 |
| 20 | Recurrent fungal infections (HP:0002841) | 4.02852274 |
| 21 | IgA deficiency (HP:0002720) | 3.87567591 |
| 22 | Abnormality of the nasal mucosa (HP:0000433) | 3.87515822 |
| 23 | Myositis (HP:0100614) | 3.82168052 |
| 24 | Abnormality of eosinophils (HP:0001879) | 3.72681053 |
| 25 | Autoimmune thrombocytopenia (HP:0001973) | 3.69732823 |
| 26 | Gastrointestinal infarctions (HP:0005244) | 3.69253819 |
| 27 | IgG deficiency (HP:0004315) | 3.59133688 |
| 28 | Leukocytosis (HP:0001974) | 3.58834270 |
| 29 | Eosinophilia (HP:0001880) | 3.52363912 |
| 30 | Increased IgM level (HP:0003496) | 3.47521328 |
| 31 | Mediastinal lymphadenopathy (HP:0100721) | 3.32237079 |
| 32 | Pustule (HP:0200039) | 3.27288084 |
| 33 | Recurrent abscess formation (HP:0002722) | 3.15318816 |
| 34 | Menstrual irregularities (HP:0000858) | 3.12964261 |
| 35 | Chronic diarrhea (HP:0002028) | 3.11252243 |
| 36 | Multiple enchondromatosis (HP:0005701) | 3.08016248 |
| 37 | Granulocytopenia (HP:0001913) | 2.90859000 |
| 38 | B lymphocytopenia (HP:0010976) | 2.82189731 |
| 39 | IgM deficiency (HP:0002850) | 2.79733877 |
| 40 | Recurrent cutaneous fungal infections (HP:0011370) | 2.79090889 |
| 41 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.79090889 |
| 42 | Glucose intolerance (HP:0000833) | 2.76537095 |
| 43 | Abnormality of oral frenula (HP:0000190) | 2.74803425 |
| 44 | Abnormality of B cell number (HP:0010975) | 2.73673057 |
| 45 | Diplopia (HP:0000651) | 2.72699515 |
| 46 | Abnormality of binocular vision (HP:0011514) | 2.72699515 |
| 47 | Thrombocytosis (HP:0001894) | 2.68621719 |
| 48 | Meningitis (HP:0001287) | 2.66083299 |
| 49 | Encephalitis (HP:0002383) | 2.64315959 |
| 50 | Hypoproteinemia (HP:0003075) | 2.58587353 |
| 51 | Bronchitis (HP:0012387) | 2.56708087 |
| 52 | Hypoplasia of the thymus (HP:0000778) | 2.54762757 |
| 53 | Thyroiditis (HP:0100646) | 2.53415807 |
| 54 | Oligomenorrhea (HP:0000876) | 2.48173555 |
| 55 | Renal cortical cysts (HP:0000803) | 2.46911247 |
| 56 | Abnormality of the prostate (HP:0008775) | 2.46168037 |
| 57 | Trigonocephaly (HP:0000243) | 2.45150994 |
| 58 | Pulmonary infiltrates (HP:0002113) | 2.43840996 |
| 59 | Hypergammaglobulinemia (HP:0010702) | 2.40983360 |
| 60 | Recurrent skin infections (HP:0001581) | 2.39408876 |
| 61 | Acute hepatic failure (HP:0006554) | 2.34373767 |
| 62 | Recurrent bacterial skin infections (HP:0005406) | 2.32804818 |
| 63 | Amyotrophic lateral sclerosis (HP:0007354) | 2.31892007 |
| 64 | Amaurosis fugax (HP:0100576) | 2.27515193 |
| 65 | Abnormality of the fingertips (HP:0001211) | 2.25935076 |
| 66 | Recurrent sinusitis (HP:0011108) | 2.25744803 |
| 67 | Hemoptysis (HP:0002105) | 2.25237774 |
| 68 | Orchitis (HP:0100796) | 2.25091069 |
| 69 | Basal cell carcinoma (HP:0002671) | 2.24803854 |
| 70 | Ureteral stenosis (HP:0000071) | 2.24435363 |
| 71 | Obstructive lung disease (HP:0006536) | 2.22095287 |
| 72 | Chronic obstructive pulmonary disease (HP:0006510) | 2.22095287 |
| 73 | Lymphoma (HP:0002665) | 2.19182112 |
| 74 | Chest pain (HP:0100749) | 2.17799405 |
| 75 | Premature loss of primary teeth (HP:0006323) | 2.17699830 |
| 76 | Pancytopenia (HP:0001876) | 2.15773927 |
| 77 | Chronic sinusitis (HP:0011109) | 2.10982540 |
| 78 | Vasculitis (HP:0002633) | 2.09773930 |
| 79 | Erythema (HP:0010783) | 2.09586066 |
| 80 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.09204086 |
| 81 | Agammaglobulinemia (HP:0004432) | 2.07819936 |
| 82 | Abnormality of T cell physiology (HP:0011840) | 2.07616975 |
| 83 | Oral leukoplakia (HP:0002745) | 2.04800056 |
| 84 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.03173681 |
| 85 | Bronchiectasis (HP:0002110) | 2.02902250 |
| 86 | Pulmonary embolism (HP:0002204) | 2.02392502 |
| 87 | Ureteral obstruction (HP:0006000) | 2.02061360 |
| 88 | Deep palmar crease (HP:0006191) | 2.00671578 |
| 89 | Hypochromic anemia (HP:0001931) | 1.95471714 |
| 90 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.94274549 |
| 91 | Periodontitis (HP:0000704) | 1.94173628 |
| 92 | Dislocated radial head (HP:0003083) | 1.92877649 |
| 93 | Arterial thrombosis (HP:0004420) | 1.92294900 |
| 94 | Keratoconjunctivitis (HP:0001096) | 1.92125530 |
| 95 | Abnormality of the pleura (HP:0002103) | 1.91794391 |
| 96 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.91144251 |
| 97 | Increased cerebral lipofuscin (HP:0011813) | 1.90809701 |
| 98 | Abnormality of the alveolar ridges (HP:0006477) | 1.88180300 |
| 99 | Spontaneous hematomas (HP:0007420) | 1.87215691 |
| 100 | Keratoconjunctivitis sicca (HP:0001097) | 1.87011561 |
| 101 | Purpura (HP:0000979) | 1.85947478 |
| 102 | Colon cancer (HP:0003003) | 1.84115290 |
| 103 | Aortic dissection (HP:0002647) | 1.83339108 |
| 104 | Increased IgE level (HP:0003212) | 1.82892818 |
| 105 | Striae distensae (HP:0001065) | 1.81688298 |
| 106 | Skin rash (HP:0000988) | 1.81676147 |
| 107 | Verrucae (HP:0200043) | 1.81262887 |
| 108 | Papilloma (HP:0012740) | 1.81262887 |
| 109 | Abnormality of macrophages (HP:0004311) | 1.81258203 |
| 110 | Epistaxis (HP:0000421) | 1.81233390 |
| 111 | Anhidrosis (HP:0000970) | 1.80658753 |
| 112 | Hepatosplenomegaly (HP:0001433) | 1.78762153 |
| 113 | Hemiplegia (HP:0002301) | 1.78686887 |
| 114 | Abnormality of the radial head (HP:0003995) | 1.78273895 |
| 115 | Arthralgia (HP:0002829) | 1.78050130 |
| 116 | Abnormal glucose tolerance (HP:0001952) | 1.76338353 |
| 117 | Abnormal platelet volume (HP:0011876) | 1.75111710 |
| 118 | Increased intramyocellular lipid droplets (HP:0012240) | 1.74791401 |
| 119 | Supernumerary ribs (HP:0005815) | 1.74568548 |
| 120 | Gangrene (HP:0100758) | 1.71672216 |
| 121 | Increased mean platelet volume (HP:0011877) | 1.71103312 |
| 122 | Acrocyanosis (HP:0001063) | 1.70116092 |
| 123 | Carpal bone hypoplasia (HP:0001498) | 1.67223447 |
| 124 | Optic neuritis (HP:0100653) | 1.65884186 |
| 125 | Retrobulbar optic neuritis (HP:0100654) | 1.65884186 |
| 126 | Polyneuropathy (HP:0001271) | 1.65202370 |
| 127 | Gastrointestinal inflammation (HP:0004386) | 1.64889308 |
| 128 | Urticaria (HP:0001025) | 1.63560509 |
| 129 | Anorexia (HP:0002039) | 1.60644642 |
| 130 | Acne (HP:0001061) | 1.60630153 |
| 131 | Metaphyseal dysplasia (HP:0100255) | 1.59338103 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 9.63305723 |
| 2 | MAP4K1 | 6.14690806 |
| 3 | PIK3CA | 5.43759615 |
| 4 | ZAP70 | 3.90350250 |
| 5 | ITK | 2.72622201 |
| 6 | STK10 | 2.63859743 |
| 7 | MST4 | 2.35159422 |
| 8 | LCK | 2.31343139 |
| 9 | EIF2AK3 | 2.21762472 |
| 10 | BCKDK | 1.90363055 |
| 11 | IKBKE | 1.85743898 |
| 12 | JAK1 | 1.84454133 |
| 13 | SYK | 1.75744108 |
| 14 | FGFR4 | 1.74968658 |
| 15 | KDR | 1.69657189 |
| 16 | NLK | 1.69014718 |
| 17 | JAK3 | 1.67182375 |
| 18 | TEC | 1.64756911 |
| 19 | GRK6 | 1.62533775 |
| 20 | LRRK2 | 1.61208517 |
| 21 | TYK2 | 1.59860526 |
| 22 | TNK2 | 1.59284056 |
| 23 | BLK | 1.59250394 |
| 24 | TESK2 | 1.55720312 |
| 25 | DAPK2 | 1.49394704 |
| 26 | CSK | 1.42991289 |
| 27 | PRKCH | 1.41943960 |
| 28 | RIPK4 | 1.41233985 |
| 29 | MAP3K14 | 1.39078940 |
| 30 | MAP3K13 | 1.33576733 |
| 31 | TBK1 | 1.32603446 |
| 32 | MAP3K12 | 1.29225143 |
| 33 | ERN1 | 1.27947067 |
| 34 | MAP3K11 | 1.23232035 |
| 35 | FGFR1 | 1.18630023 |
| 36 | PRPF4B | 1.17075216 |
| 37 | FYN | 1.10870249 |
| 38 | LYN | 1.09580881 |
| 39 | VRK2 | 1.09336588 |
| 40 | FES | 1.09241780 |
| 41 | PRKCQ | 1.07028861 |
| 42 | BTK | 1.04095452 |
| 43 | NUAK1 | 1.02479519 |
| 44 | KIT | 0.99547961 |
| 45 | CSF1R | 0.98701847 |
| 46 | MAPKAPK3 | 0.97158878 |
| 47 | CLK1 | 0.95205751 |
| 48 | IKBKB | 0.93336662 |
| 49 | HCK | 0.92768589 |
| 50 | TAOK1 | 0.92507838 |
| 51 | EEF2K | 0.92364793 |
| 52 | PASK | 0.91119946 |
| 53 | MAPK11 | 0.90798296 |
| 54 | SIK2 | 0.87171327 |
| 55 | ACVR1B | 0.86391559 |
| 56 | PKN2 | 0.81783092 |
| 57 | TAOK3 | 0.81579943 |
| 58 | VRK1 | 0.79384721 |
| 59 | IGF1R | 0.77139713 |
| 60 | TESK1 | 0.75242660 |
| 61 | CAMKK2 | 0.74802083 |
| 62 | TGFBR1 | 0.72752292 |
| 63 | TLK1 | 0.71999717 |
| 64 | INSR | 0.69042033 |
| 65 | TAOK2 | 0.67807942 |
| 66 | CAMKK1 | 0.66156929 |
| 67 | FGFR3 | 0.63164502 |
| 68 | MARK3 | 0.59795147 |
| 69 | MAP3K3 | 0.59657372 |
| 70 | RPS6KA4 | 0.58755478 |
| 71 | PIM1 | 0.57723008 |
| 72 | PRKD3 | 0.55690509 |
| 73 | ROCK2 | 0.55290025 |
| 74 | CHUK | 0.52162819 |
| 75 | MARK2 | 0.49787764 |
| 76 | PIK3CG | 0.48305981 |
| 77 | EPHA3 | 0.46497552 |
| 78 | MAP3K7 | 0.45746396 |
| 79 | RIPK1 | 0.45498822 |
| 80 | MAP2K7 | 0.45081106 |
| 81 | ALK | 0.44685687 |
| 82 | RPS6KA5 | 0.44656452 |
| 83 | EPHB1 | 0.43859589 |
| 84 | SIK3 | 0.43676862 |
| 85 | JAK2 | 0.43275248 |
| 86 | BMPR2 | 0.43172955 |
| 87 | PDK1 | 0.42801602 |
| 88 | MAPKAPK2 | 0.42229594 |
| 89 | TRIB3 | 0.41590047 |
| 90 | ADRBK2 | 0.40605404 |
| 91 | NME2 | 0.37883280 |
| 92 | MOS | 0.36125278 |
| 93 | SIK1 | 0.34500716 |
| 94 | PDGFRB | 0.33786720 |
| 95 | MAPK4 | 0.33727406 |
| 96 | ILK | 0.31920086 |
| 97 | PAK1 | 0.31565556 |
| 98 | MAP3K5 | 0.31275684 |
| 99 | FGR | 0.29912278 |
| 100 | NEK6 | 0.29828570 |
| 101 | MYLK | 0.29625287 |
| 102 | MAP3K8 | 0.27748283 |
| 103 | IRAK4 | 0.27145158 |
| 104 | MAP3K1 | 0.25743354 |
| 105 | RET | 0.25600406 |
| 106 | CDK12 | 0.25213570 |
| 107 | CDK8 | 0.24808430 |
| 108 | STK38 | 0.24710589 |
| 109 | SRC | 0.24499695 |
| 110 | TGFBR2 | 0.23895319 |
| 111 | TYRO3 | 0.22102582 |
| 112 | MAPK13 | 0.20820210 |
| 113 | MAP2K3 | 0.20005816 |
| 114 | PRKCD | 0.19810444 |
| 115 | MAPK3 | 0.18276291 |
| 116 | DAPK1 | 0.18029339 |
| 117 | MAPK7 | 0.17692018 |
| 118 | EIF2AK1 | 0.17615014 |
| 119 | CDK4 | 0.17501916 |
| 120 | SCYL2 | 0.16891864 |
| 121 | ABL1 | 0.16851063 |
| 122 | MAPK9 | 0.16441636 |
| 123 | MAPK12 | 0.14644706 |
| 124 | CAMK4 | 0.14320632 |
| 125 | HIPK2 | 0.14117907 |
| 126 | TTN | 0.13607209 |
| 127 | FLT3 | 0.13253441 |
| 128 | BUB1 | 0.12877539 |
| 129 | MAP3K10 | 0.11560912 |
| 130 | PRKD2 | 0.11199465 |
| 131 | EGFR | 0.10959810 |
| 132 | MAP2K6 | 0.08066345 |
| 133 | PRKCB | 0.06796647 |
| 134 | RPS6KA6 | 0.06276734 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 7.51342903 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 6.12570125 |
| 3 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 5.02668010 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 4.64670078 |
| 5 | Antigen processing and presentation_Homo sapiens_hsa04612 | 3.90599181 |
| 6 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 3.52462531 |
| 7 | Measles_Homo sapiens_hsa05162 | 2.94543260 |
| 8 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.14137540 |
| 9 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 2.09364138 |
| 10 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.88703401 |
| 11 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.81348511 |
| 12 | Viral myocarditis_Homo sapiens_hsa05416 | 1.76548236 |
| 13 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.66855386 |
| 14 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.57795363 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.41318836 |
| 16 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.31663889 |
| 17 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.31520213 |
| 18 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.30993100 |
| 19 | Allograft rejection_Homo sapiens_hsa05330 | 1.30539334 |
| 20 | Ribosome_Homo sapiens_hsa03010 | 1.26775707 |
| 21 | Shigellosis_Homo sapiens_hsa05131 | 1.22920604 |
| 22 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.17880898 |
| 23 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.14998679 |
| 24 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.13073729 |
| 25 | Leishmaniasis_Homo sapiens_hsa05140 | 1.11235016 |
| 26 | HTLV-I infection_Homo sapiens_hsa05166 | 1.08903081 |
| 27 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.03697812 |
| 28 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.02827258 |
| 29 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.01243281 |
| 30 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.95591684 |
| 31 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.94968186 |
| 32 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.90847532 |
| 33 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.88590526 |
| 34 | Apoptosis_Homo sapiens_hsa04210 | 0.84576319 |
| 35 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.82390912 |
| 36 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.81930557 |
| 37 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.80784535 |
| 38 | Colorectal cancer_Homo sapiens_hsa05210 | 0.79826937 |
| 39 | Hepatitis B_Homo sapiens_hsa05161 | 0.77969630 |
| 40 | RNA polymerase_Homo sapiens_hsa03020 | 0.77457527 |
| 41 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.77179103 |
| 42 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.74484023 |
| 43 | Asthma_Homo sapiens_hsa05310 | 0.67948431 |
| 44 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.67746385 |
| 45 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.67649718 |
| 46 | Alcoholism_Homo sapiens_hsa05034 | 0.65721827 |
| 47 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.64794571 |
| 48 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.64059861 |
| 49 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.63674633 |
| 50 | Influenza A_Homo sapiens_hsa05164 | 0.61256719 |
| 51 | Tuberculosis_Homo sapiens_hsa05152 | 0.61087356 |
| 52 | Legionellosis_Homo sapiens_hsa05134 | 0.60615469 |
| 53 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.60491555 |
| 54 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.59783047 |
| 55 | Malaria_Homo sapiens_hsa05144 | 0.58624076 |
| 56 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.58309104 |
| 57 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.58042718 |
| 58 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.56319091 |
| 59 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.54791057 |
| 60 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.54213119 |
| 61 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.53476464 |
| 62 | Platelet activation_Homo sapiens_hsa04611 | 0.52607865 |
| 63 | Endocytosis_Homo sapiens_hsa04144 | 0.51739739 |
| 64 | Salmonella infection_Homo sapiens_hsa05132 | 0.51549825 |
| 65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.50649237 |
| 66 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.49001089 |
| 67 | Protein export_Homo sapiens_hsa03060 | 0.47137942 |
| 68 | Proteasome_Homo sapiens_hsa03050 | 0.46438576 |
| 69 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.45745944 |
| 70 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.45486664 |
| 71 | Prion diseases_Homo sapiens_hsa05020 | 0.45386399 |
| 72 | Hepatitis C_Homo sapiens_hsa05160 | 0.41142335 |
| 73 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.40757544 |
| 74 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.39705695 |
| 75 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.36148687 |
| 76 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.35643377 |
| 77 | Parkinsons disease_Homo sapiens_hsa05012 | 0.35249166 |
| 78 | Pertussis_Homo sapiens_hsa05133 | 0.31656816 |
| 79 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.30981756 |
| 80 | ABC transporters_Homo sapiens_hsa02010 | 0.30137044 |
| 81 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.26573702 |
| 82 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.26257208 |
| 83 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.25838458 |
| 84 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.23585550 |
| 85 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.23281112 |
| 86 | Spliceosome_Homo sapiens_hsa03040 | 0.21931002 |
| 87 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.21817097 |
| 88 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.21225156 |
| 89 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.20845104 |
| 90 | Insulin resistance_Homo sapiens_hsa04931 | 0.19767636 |
| 91 | Mismatch repair_Homo sapiens_hsa03430 | 0.18640367 |
| 92 | Peroxisome_Homo sapiens_hsa04146 | 0.18568819 |
| 93 | Galactose metabolism_Homo sapiens_hsa00052 | 0.17942303 |
| 94 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.17893099 |
| 95 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.16278963 |
| 96 | RNA degradation_Homo sapiens_hsa03018 | 0.13983381 |
| 97 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.13864859 |
| 98 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.13167952 |
| 99 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.12962973 |
| 100 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.12522753 |
| 101 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.12439842 |
| 102 | Lysosome_Homo sapiens_hsa04142 | 0.12248530 |
| 103 | Adherens junction_Homo sapiens_hsa04520 | 0.11197336 |
| 104 | Alzheimers disease_Homo sapiens_hsa05010 | 0.10968226 |
| 105 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.10961082 |
| 106 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.10565748 |
| 107 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.10064486 |
| 108 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.09777494 |
| 109 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.09343881 |
| 110 | Phagosome_Homo sapiens_hsa04145 | 0.07897902 |
| 111 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.07713185 |
| 112 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.07582022 |
| 113 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.06508829 |
| 114 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.06337956 |
| 115 | Thyroid cancer_Homo sapiens_hsa05216 | 0.06217579 |
| 116 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.05946982 |
| 117 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.05531317 |
| 118 | Mineral absorption_Homo sapiens_hsa04978 | 0.03940093 |
| 119 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.03377989 |
| 120 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.01557943 |
| 121 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.01198784 |
| 122 | MicroRNAs in cancer_Homo sapiens_hsa05206 | -0.0327133 |
| 123 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | -0.0312718 |
| 124 | Prostate cancer_Homo sapiens_hsa05215 | -0.0293774 |
| 125 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | -0.0249240 |
| 126 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | -0.0214804 |
| 127 | Ras signaling pathway_Homo sapiens_hsa04014 | -0.0095085 |
| 128 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | -0.0082144 |

